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Conserved domains on  [gi|1705230454|ref|WP_142586907|]
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protein-L-isoaspartate O-methyltransferase [Pseudorhizobium halotolerans]

Protein Classification

protein-L-isoaspartate O-methyltransferase family protein( domain architecture ID 11457531)

protein-L-isoaspartate O-methyltransferase family protein may catalyze the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

CATH:  3.55.20.10
EC:  2.1.1.77
Gene Ontology:  GO:0004719|GO:0030091|GO:0036211
PubMed:  35462043|20564550|35462043|9253175
SCOP:  4000666

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 16-236 9.73e-39

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 134.83  E-value: 9.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  16 QVLAKAGVAnDPRLLDALASVEREPFFGPPpwfysdfstYRELAshdpvvlYQDMLVALDPARHVNNgvPSLHAGALNQL 95
Cdd:COG2518     2 QQLRPRGVT-DPRVLDAMRAVPRELFVPEA---------LRELA-------YADRALPIGHGQTISQ--PYIVARMLEAL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  96 GVRPGERVAHLGAGTGYYTAILAELVgpsGHVTAVEYDGELAGKAAGAL--HNRANVTVIHGD-ALVFPQAA-VDVVYVN 171
Cdd:COG2518    63 DLKPGDRVLEIGTGSGYQAAVLARLA---GRVYSVERDPELAERARERLaaLGYDNVTVRVGDgALGWPEHApFDRIIVT 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1705230454 172 FALDHPAAAWVDQLAPGGRLLFPLGIPARSangeQLpftsmagfLLIDRRPAGYGARFLQPASFV 236
Cdd:COG2518   140 AAAPEVPEALLEQLAPGGRLVAPVGEGGVQ----RL--------VLITRTGDGFERESLFEVRFV 192
 
Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 16-236 9.73e-39

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 134.83  E-value: 9.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  16 QVLAKAGVAnDPRLLDALASVEREPFFGPPpwfysdfstYRELAshdpvvlYQDMLVALDPARHVNNgvPSLHAGALNQL 95
Cdd:COG2518     2 QQLRPRGVT-DPRVLDAMRAVPRELFVPEA---------LRELA-------YADRALPIGHGQTISQ--PYIVARMLEAL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  96 GVRPGERVAHLGAGTGYYTAILAELVgpsGHVTAVEYDGELAGKAAGAL--HNRANVTVIHGD-ALVFPQAA-VDVVYVN 171
Cdd:COG2518    63 DLKPGDRVLEIGTGSGYQAAVLARLA---GRVYSVERDPELAERARERLaaLGYDNVTVRVGDgALGWPEHApFDRIIVT 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1705230454 172 FALDHPAAAWVDQLAPGGRLLFPLGIPARSangeQLpftsmagfLLIDRRPAGYGARFLQPASFV 236
Cdd:COG2518   140 AAAPEVPEALLEQLAPGGRLVAPVGEGGVQ----RL--------VLITRTGDGFERESLFEVRFV 192
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
18-225 5.97e-25

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 98.98  E-value: 5.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  18 LAKAGVANDPRLLDALASVEREPFFGPPPWFYSdfstyrelashdpvvlYQDmlVALDPARHVNNGVPSLHAGALNQLGV 97
Cdd:pfam01135  10 LKNYGVIKSDKVAEAMLAVDREEFVPESFKSYA----------------YED--IPLSIGYGQTISAPHMHAMMLELLEL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  98 RPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGAL--HNRANVTVIHGDA-LVFPQAA-VDVVYVNFA 173
Cdd:pfam01135  72 KPGMRVLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLekLGLENVIVVVGDGrQGWPEFApYDAIHVGAA 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1705230454 174 LDHPAAAWVDQLAPGGRLLFPLGiparsANGEQLpftsmagFLLIDRRPAGY 225
Cdd:pfam01135 152 APEIPEALIDQLKEGGRLVIPVG-----PNGNQV-------LQQFDKRNDGS 191
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 85-195 8.69e-22

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 93.97  E-value: 8.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  85 PSLHAGALNQLGVRPGERVAHLGAGtGYYTAILAELVGPSGHVTAVEYDGELAGKAAGAL--HNRANVTVIHGDAL--VF 160
Cdd:TIGR04364  68 PHIQAMMLEQAGVEPGMRVLEIGSG-GYNAALLAELVGPSGEVTTVDIDEDVTDRARACLaaAGYPQVTVVLADAEagVP 146

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1705230454 161 PQAAVDVVYVNFALDHPAAAWVDQLAPGGRLLFPL 195
Cdd:TIGR04364 147 ELAPYDRIIVTVGAWDIPPAWLDQLAPGGRLVVPL 181
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 95-196 2.58e-16

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 75.82  E-value: 2.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  95 LGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGALHNRA--NVTVIHGDALV--FPQAAVDVVYV 170
Cdd:PRK13942   72 LDLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKKLGydNVEVIVGDGTLgyEENAPYDRIYV 151

                          90       100
                  ....*....|....*....|....*.
gi 1705230454 171 NFALDHPAAAWVDQLAPGGRLLFPLG 196
Cdd:PRK13942  152 TAAGPDIPKPLIEQLKDGGIMVIPVG 177
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 102-197 8.16e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 8.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454 102 RVAHLGAGTGYYTAILAElvGPSGHVTAVEYDGELAGKA--AGALHNRANVTVIHGDALVFPQAA---VDVVYVNFALDH 176
Cdd:cd02440     1 RVLDLGCGTGALALALAS--GPGARVTGVDISPVALELArkAAAALLADNVEVLKGDAEELPPEAdesFDVIISDPPLHH 78

                          90       100
                  ....*....|....*....|.
gi 1705230454 177 PAAAWVDQLAPGGRLLFPLGI 197
Cdd:cd02440    79 LVEDLARFLEEARRLLKPGGV 99
rADc smart00650
Ribosomal RNA adenine dimethylases;
92-171 2.08e-08

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 52.51  E-value: 2.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454   92 LNQLGVRPGERVAHLGAGTGYYTAILAELvgpSGHVTAVEYDGELAGKAAGALHNRANVTVIHGDAL--VFPQAAVDVVY 169
Cdd:smart00650   6 VRAANLRPGDTVLEIGPGKGALTEELLER---AKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALkfDLPKLQPYKVV 82


                   ..
gi 1705230454  170 VN 171
Cdd:smart00650  83 GN 84
 
Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 16-236 9.73e-39

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 134.83  E-value: 9.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  16 QVLAKAGVAnDPRLLDALASVEREPFFGPPpwfysdfstYRELAshdpvvlYQDMLVALDPARHVNNgvPSLHAGALNQL 95
Cdd:COG2518     2 QQLRPRGVT-DPRVLDAMRAVPRELFVPEA---------LRELA-------YADRALPIGHGQTISQ--PYIVARMLEAL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  96 GVRPGERVAHLGAGTGYYTAILAELVgpsGHVTAVEYDGELAGKAAGAL--HNRANVTVIHGD-ALVFPQAA-VDVVYVN 171
Cdd:COG2518    63 DLKPGDRVLEIGTGSGYQAAVLARLA---GRVYSVERDPELAERARERLaaLGYDNVTVRVGDgALGWPEHApFDRIIVT 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1705230454 172 FALDHPAAAWVDQLAPGGRLLFPLGIPARSangeQLpftsmagfLLIDRRPAGYGARFLQPASFV 236
Cdd:COG2518   140 AAAPEVPEALLEQLAPGGRLVAPVGEGGVQ----RL--------VLITRTGDGFERESLFEVRFV 192
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
18-225 5.97e-25

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 98.98  E-value: 5.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  18 LAKAGVANDPRLLDALASVEREPFFGPPPWFYSdfstyrelashdpvvlYQDmlVALDPARHVNNGVPSLHAGALNQLGV 97
Cdd:pfam01135  10 LKNYGVIKSDKVAEAMLAVDREEFVPESFKSYA----------------YED--IPLSIGYGQTISAPHMHAMMLELLEL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  98 RPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGAL--HNRANVTVIHGDA-LVFPQAA-VDVVYVNFA 173
Cdd:pfam01135  72 KPGMRVLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLekLGLENVIVVVGDGrQGWPEFApYDAIHVGAA 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1705230454 174 LDHPAAAWVDQLAPGGRLLFPLGiparsANGEQLpftsmagFLLIDRRPAGY 225
Cdd:pfam01135 152 APEIPEALIDQLKEGGRLVIPVG-----PNGNQV-------LQQFDKRNDGS 191
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 85-195 8.69e-22

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 93.97  E-value: 8.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  85 PSLHAGALNQLGVRPGERVAHLGAGtGYYTAILAELVGPSGHVTAVEYDGELAGKAAGAL--HNRANVTVIHGDAL--VF 160
Cdd:TIGR04364  68 PHIQAMMLEQAGVEPGMRVLEIGSG-GYNAALLAELVGPSGEVTTVDIDEDVTDRARACLaaAGYPQVTVVLADAEagVP 146

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1705230454 161 PQAAVDVVYVNFALDHPAAAWVDQLAPGGRLLFPL 195
Cdd:TIGR04364 147 ELAPYDRIIVTVGAWDIPPAWLDQLAPGGRLVVPL 181
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 18-236 4.84e-20

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 86.03  E-value: 4.84e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  18 LAKAGVANDPRLLDALASVEREPFFGPPPWFYSdfstyrelashdpvvlYQDMLVALDPARHVNNgvPSLHAGALNQLGV 97
Cdd:TIGR00080  14 LINEGYIKSKRVIDALLSVPREEFVPEHFKEYA----------------YVDTPLEIGYGQTISA--PHMVAMMTELLEL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  98 RPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGALHN--RANVTVIHGDALV--FPQAAVDVVYVNFA 173
Cdd:TIGR00080  76 KPGMKVLEIGTGSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRKlgLDNVIVIVGDGTQgwEPLAPYDRIYVTAA 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1705230454 174 LDHPAAAWVDQLAPGGRLLFPLGiparsaNGEQLpftsmagFLLIDRRPAGYGARFLQPASFV 236
Cdd:TIGR00080 156 GPKIPEALIDQLKEGGILVMPVG------EYLQV-------LKRAEKRGGEIIIKDVEPVAFV 205
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 95-196 2.58e-16

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 75.82  E-value: 2.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  95 LGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGALHNRA--NVTVIHGDALV--FPQAAVDVVYV 170
Cdd:PRK13942   72 LDLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKKLGydNVEVIVGDGTLgyEENAPYDRIYV 151

                          90       100
                  ....*....|....*....|....*.
gi 1705230454 171 NFALDHPAAAWVDQLAPGGRLLFPLG 196
Cdd:PRK13942  152 TAAGPDIPKPLIEQLKDGGIMVIPVG 177
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
99-193 2.42e-15

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 70.24  E-value: 2.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  99 PGERVAHLGAGTGYYTAILAELVgPSGHVTAVEYDGELAGKAAGALhnrANVTVIHGDALVF-PQAAVDVVYVNFAL--- 174
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERF-PGARVTGVDLSPEMLARARARL---PNVRFVVADLRDLdPPEPFDLVVSNAALhwl 76

                          90       100
                  ....*....|....*....|..
gi 1705230454 175 -DHPA--AAWVDQLAPGGRLLF 193
Cdd:COG4106    77 pDHAAllARLAAALAPGGVLAV 98
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 91-193 3.70e-15

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 70.79  E-value: 3.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  91 ALNQLGVRPGERVAHLGAGTGYYTAILAELvgpSGHVTAVEYDGELAGKAAGALHNR-ANVTVIHGDA--LVFPQAAVDV 167
Cdd:COG2226    14 LLAALGLRPGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAEAgLNVEFVVGDAedLPFPDGSFDL 90

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1705230454 168 VYVNFALDH---PAAA---WVDQLAPGGRLLF 193
Cdd:COG2226    91 VISSFVLHHlpdPERAlaeIARVLKPGGRLVV 122
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 17-197 8.91e-15

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 73.34  E-value: 8.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  17 VLAKAGVanDPRLLDALASVEREPFFG---PPPWFYSDFStyrelashdpVVLYQDMLValdparHVNNGVPSLHAGALN 93
Cdd:PRK13943   13 ILKKYGI--SDHIAKAFLEVPREEFLTksyPLSYVYEDIV----------LVSYDDGEE------YSTSSQPSLMALFME 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  94 QLGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGEL---AGKAAGALhNRANVTVIHGDAL--VFPQAAVDVV 168
Cdd:PRK13943   75 WVGLDKGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKIceiAKRNVRRL-GIENVIFVCGDGYygVPEFAPYDVI 153

                         170       180
                  ....*....|....*....|....*....
gi 1705230454 169 YVNFALDHPAAAWVDQLAPGGRLLFPLGI 197
Cdd:PRK13943  154 FVTVGVDEVPETWFTQLKEGGRVIVPINL 182
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 97-193 7.82e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 61.19  E-value: 7.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  97 VRPGERVAHLGAGTGYYTAILAELvgpsGH-VTAVEYDGELAGKAAgALHNRANVTVIHGDA--LVFPQAAVDVVYVNFA 173
Cdd:COG2227    22 LPAGGRVLDVGCGTGRLALALARR----GAdVTGVDISPEALEIAR-ERAAELNVDFVQGDLedLPLEDGSFDLVICSEV 96

                          90       100
                  ....*....|....*....|....*.
gi 1705230454 174 LDH---PAAAW---VDQLAPGGRLLF 193
Cdd:COG2227    97 LEHlpdPAALLrelARLLKPGGLLLL 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 102-197 8.16e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 8.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454 102 RVAHLGAGTGYYTAILAElvGPSGHVTAVEYDGELAGKA--AGALHNRANVTVIHGDALVFPQAA---VDVVYVNFALDH 176
Cdd:cd02440     1 RVLDLGCGTGALALALAS--GPGARVTGVDISPVALELArkAAAALLADNVEVLKGDAEELPPEAdesFDVIISDPPLHH 78

                          90       100
                  ....*....|....*....|.
gi 1705230454 177 PAAAWVDQLAPGGRLLFPLGI 197
Cdd:cd02440    79 LVEDLARFLEEARRLLKPGGV 99
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 95-193 1.44e-11

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 62.87  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  95 LGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGALHN---RANVTVIHGDAL-VFPQAAVDVVyv 170
Cdd:COG2519    87 LDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERfglPDNVELKLGDIReGIDEGDVDAV-- 164

                          90       100
                  ....*....|....*....|....*....
gi 1705230454 171 nfALDHPaAAW--VDQ----LAPGGRLLF 193
Cdd:COG2519   165 --FLDMP-DPWeaLEAvakaLKPGGVLVA 190
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
26-196 2.14e-11

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 62.14  E-value: 2.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  26 DPRLLDALASVEREPFFgPPPWF---YSDfstyRELashdPVVLYQDMLVALDPARhvnngvpslhagALNQLGVRPGER 102
Cdd:PRK00312   23 DERVLEAIEATPRELFV-PEAFKhkaYEN----RAL----PIGCGQTISQPYMVAR------------MTELLELKPGDR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454 103 VAHLGAGTGYYTAILAELVgpsGHVTAVEYDGELAGKAAGALH--NRANVTVIHGD-ALVFP-QAAVDVVYVNFALDHPA 178
Cdd:PRK00312   82 VLEIGTGSGYQAAVLAHLV---RRVFSVERIKTLQWEAKRRLKqlGLHNVSVRHGDgWKGWPaYAPFDRILVTAAAPEIP 158

                         170
                  ....*....|....*...
gi 1705230454 179 AAWVDQLAPGGRLLFPLG 196
Cdd:PRK00312  159 RALLEQLKEGGILVAPVG 176
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 106-189 1.83e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 56.80  E-value: 1.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454 106 LGAGTGYYTAILAELVGpsGHVTAVEYDGELAGKAAG-ALHNRANVTVIHGDA--LVFPQAAVDVVYVNFALDHPAAAWV 182
Cdd:pfam13649   4 LGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARErAAEAGLNVEFVQGDAedLPFPDGSFDLVVSSGVLHHLPDPDL 81

                          90
                  ....*....|....*
gi 1705230454 183 DQ--------LAPGG 189
Cdd:pfam13649  82 EAalreiarvLKPGG 96
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 18-195 6.68e-10

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 57.52  E-value: 6.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  18 LAKAGVANDPRLLDALASVEREPFFGPppwfysdfsTYRELASHD-PVVLYQDMLVAldparhvnngVPSLHAGALNQLG 96
Cdd:PRK13944    9 LVREGIIKSERVKKAMLSVPREEFVMP---------EYRMMAYEDrPLPLFAGATIS----------APHMVAMMCELIE 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  97 VRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGALHNRAN---VTVIHGDAL--VFPQAAVDVVYVN 171
Cdd:PRK13944   70 PRPGMKILEVGTGSGYQAAVCAEAIERRGKVYTVEIVKELAIYAAQNIERLGYwgvVEVYHGDGKrgLEKHAPFDAIIVT 149

                         170       180
                  ....*....|....*....|....
gi 1705230454 172 FALDHPAAAWVDQLAPGGRLLFPL 195
Cdd:PRK13944  150 AAASTIPSALVRQLKDGGVLVIPV 173
PRK08317 PRK08317
hypothetical protein; Provisional
 95-192 3.85e-09

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 56.10  E-value: 3.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  95 LGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEY-DGELAGKAAGALHNRANVTVIHGDA--LVFPQAAVDVVYVN 171
Cdd:PRK08317   15 LAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRsEAMLALAKERAAGLGPNVEFVRGDAdgLPFPDGSFDAVRSD 94

                          90       100
                  ....*....|....*....|....*...
gi 1705230454 172 FALDH---PAAAwVDQLA----PGGRLL 192
Cdd:PRK08317   95 RVLQHledPARA-LAEIArvlrPGGRVV 121
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 91-192 7.42e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 55.16  E-value: 7.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  91 ALNQLGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGEL---AGKAAGALHNRANVTVIHGDA--LVFPQAAV 165
Cdd:PRK00216   43 TIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKTGEVVGLDFSEGMlavGREKLRDLGLSGNVEFVQGDAeaLPFPDNSF 122

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1705230454 166 DVVYVNFAL----DHPAA----AWVdqLAPGGRLL 192
Cdd:PRK00216  123 DAVTIAFGLrnvpDIDKAlremYRV--LKPGGRLV 155
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 106-193 8.72e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 51.90  E-value: 8.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454 106 LGAGTGYYTAILAELVgpsGHVTAVEYDGELAgKAAGALHNRANVTVIHGDA--LVFPQAAVDVVYVNFALDH---PAAA 180
Cdd:pfam08241   3 VGCGTGLLTELLARLG---ARVTGVDISPEML-ELAREKAPREGLTFVVGDAedLPFPDNSFDLVLSSEVLHHvedPERA 78

                          90
                  ....*....|....*.
gi 1705230454 181 ---WVDQLAPGGRLLF 193
Cdd:pfam08241  79 lreIARVLKPGGILII 94
rADc smart00650
Ribosomal RNA adenine dimethylases;
92-171 2.08e-08

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 52.51  E-value: 2.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454   92 LNQLGVRPGERVAHLGAGTGYYTAILAELvgpSGHVTAVEYDGELAGKAAGALHNRANVTVIHGDAL--VFPQAAVDVVY 169
Cdd:smart00650   6 VRAANLRPGDTVLEIGPGKGALTEELLER---AKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALkfDLPKLQPYKVV 82


                   ..
gi 1705230454  170 VN 171
Cdd:smart00650  83 GN 84
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 98-192 2.14e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.42  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  98 RPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAG--ALHNRANVTVIHGDALVFPQA----AVDVVYVN 171
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKAREnaQKLGFDNVEFEQGDIEELPELleddKFDVVISN 81

                          90       100
                  ....*....|....*....|....*..
gi 1705230454 172 FALDH---PAAAWV---DQLAPGGRLL 192
Cdd:pfam13847  82 CVLNHipdPDKVLQeilRVLKPGGRLI 108
COG4798 COG4798
Predicted methyltransferase [General function prediction only];
72-167 2.47e-08

Predicted methyltransferase [General function prediction only];


Pssm-ID: 443826  Cd Length: 274  Bit Score: 53.77  E-value: 2.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  72 VALDPARHvnngvPslhAGALNQLGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGALHNRANVT 151
Cdd:COG4798    47 RARDAYRH-----P---AETLAFFGVKPGMTVVEIWPGGGWYTEILAPYLGPKGKVYAANFDPDSEPPEYAKRSREAFSA 118

                          90
                  ....*....|....*.
gi 1705230454 152 VIHGDALVFPQAAVDV 167
Cdd:COG4798   119 KLAADPALYGNVRVTA 134
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 93-158 1.46e-07

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 51.66  E-value: 1.46e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1705230454  93 NQLGVRPGERVAHLGAGTGYYTAILAELVGpsgHVTAVEYDGELAGKAAGALHNRANVTVIHGDAL 158
Cdd:COG0030    31 DAAGITPGDTVLEIGPGLGALTRALLERAA---RVTAVEIDRRLAAILRETFAAYPNLTVIEGDAL 93
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 85-263 2.12e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 50.30  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  85 PSLHAGALNQLGVRPGERVAHLGAGTGYYTAILAELVGpsGHVTAVEYDGEL--AGKAAGALHNRANVTVIHGDALVF-- 160
Cdd:COG0500    12 PGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAiaLARARAAKAGLGNVEFLVADLAELdp 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454 161 -PQAAVDVVYVNFALDH--PA------AAWVDQLAPGGRLLFplgIPARSANGEQLPFTSMAGFLLIDRRPAGYGARFLQ 231
Cdd:COG0500    90 lPAESFDLVVAFGVLHHlpPEereallRELARALKPGGVLLL---SASDAAAALSLARLLLLATASLLELLLLLRLLALE 166

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1705230454 232 PASFVFAEGQEPPPASRREGLEAAFRRRIADQ 263
Cdd:COG0500   167 LYLRALLAAAATEDLRSDALLESANALEYLLS 198
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 105-191 4.04e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 47.36  E-value: 4.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454 105 HLGAGTGYYTAILAELVgPSGHVTAVEYDGELAGKAAGAL-----HNRANVTVIHGDALVFPQAAVDVVYVNFALDH--P 177
Cdd:pfam08242   2 EIGCGTGTLLRALLEAL-PGLEYTGLDISPAALEAARERLaalglLNAVRVELFQLDLGELDPGSFDVVVASNVLHHlaD 80

                          90
                  ....*....|....*...
gi 1705230454 178 AAAWVDQ----LAPGGRL 191
Cdd:pfam08242  81 PRAVLRNirrlLKPGGVL 98
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 92-193 1.16e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 47.88  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  92 LNQLGVRPGERVAHLGAGTGYYTAILAELvGPSGHVTAVEYDG---ELAGKAAgALHNRANVTVIHGDALV-FPQAAVDV 167
Cdd:COG2813    42 LEHLPEPLGGRVLDLGCGYGVIGLALAKR-NPEARVTLVDVNAravELARANA-AANGLENVEVLWSDGLSgVPDGSFDL 119

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1705230454 168 VYVN-------FALDHPA----AAWVDQLAPGGRLLF 193
Cdd:COG2813   120 ILSNppfhagrAVDKEVAhaliADAARHLRPGGELWL 156
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 92-193 4.40e-06

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 46.90  E-value: 4.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  92 LNQLGVRPGERVAHLGAGTGYYTAILAELvGPSGHVTAVE-YDGELAGKAAgalHNRANVTVIHGDA--LVFPQAAVDVV 168
Cdd:TIGR02072  27 LKEKGIFIPASVLDIGCGTGYLTRALLKR-FPQAEFIALDiSAGMLAQAKT---KLSENVQFICGDAekLPLEDSSFDLI 102

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1705230454 169 YVNFALDhpaaaWVDQLA-----------PGGRLLF 193
Cdd:TIGR02072 103 VSNLALQ-----WCDDLSqalselarvlkPGGLLAF 133
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 91-171 4.71e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 47.48  E-value: 4.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  91 ALNQLGVRPGERVAHLGAGTGYYTAILAELVgpsGHVTAVEYDGEL--AGKAAGALHNRANVTVIHGDAL-VFPQ----A 163
Cdd:COG2265   225 ALEWLDLTGGERVLDLYCGVGTFALPLARRA---KKVIGVEIVPEAveDARENARLNGLKNVEFVAGDLEeVLPEllwgG 301


                  ....*...
gi 1705230454 164 AVDVVYVN 171
Cdd:COG2265   302 RPDVVVLD 309
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 102-170 5.80e-06

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 45.56  E-value: 5.80e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1705230454 102 RVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKA------AGaLHNRanVTVIHGDAL-VFPQ---AAVDVVYV 170
Cdd:COG4122    19 RILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIArenfarAG-LADR--IRLILGDALeVLPRladGPFDLVFI 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
87-193 9.39e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 45.37  E-value: 9.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  87 LHAGALNQLGVRPGERVAHLGAGTGYYTAILAELVgpsGHVTAVEYDGELAGKAAGalhNRANVTVIHGD--ALVFPQAA 164
Cdd:COG4976    34 LAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG---YRLTGVDLSEEMLAKARE---KGVYDRLLVADlaDLAEPDGR 107

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1705230454 165 VDVVYVNFALDH-----PAAAWV-DQLAPGGRLLF 193
Cdd:COG4976   108 FDLIVAADVLTYlgdlaAVFAGVaRALKPGGLFIF 142
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
85-160 1.05e-05

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 45.82  E-value: 1.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1705230454  85 PSLHAGALNQLGVRPGERVAHLGAGTGYYTAILAELvgpSGHVTAVEYDGELAGKAAGALHNRANVTVIHGDALVF 160
Cdd:pfam00398  16 PKVINEIVDKANLRESDTVLEIGPGKGALTVILAKR---AKQVVAIEIDPRLAKLLQKKLSLDENLTVIHQDFLKF 88
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
97-168 1.25e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 45.41  E-value: 1.25e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1705230454  97 VRPGERVAHLGAGTGyytaILAELVGPSG--HVTAVEYDGEL---AGKAAGALHNRANVTVIHGDALVF-PQAAVDVV 168
Cdd:COG4076    33 VKPGDVVLDIGTGSG----LLSMLAARAGakKVYAVEVNPDIaavARRIIAANGLSDRITVINADATDLdLPEKADVI 106
Fibrillarin pfam01269
Fibrillarin;
90-201 1.55e-05

Fibrillarin;


Pssm-ID: 396019  Cd Length: 227  Bit Score: 45.28  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  90 GALNQLGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDG----ELAGKAAGalhnRANVTVIHGDAlVFPQ--- 162
Cdd:pfam01269  62 KGLKEIPIKPGSKVLYLGAASGTTVSHVSDIVGPEGVVYAVEFSPrvgrELINVAKK----RPNIVPILEDA-RHPQkyr 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1705230454 163 ---AAVDVVYVNFALDHPAAAWVDQ----LAPGGRLLfpLGIPARS 201
Cdd:pfam01269 137 mlvEMVDVIFADVAQPDQARILALNaryfLKEGGYFM--ISIKARS 180
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 92-193 3.03e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 43.38  E-value: 3.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  92 LNQLGVRPGERVAHLGAGTGYYTAILAELVGpsGHVTAVEYDGELAGKA---AGALHNRANVTVIHGDAL-VFPQAAVDV 167
Cdd:COG2230    44 LRKLGLKPGMRVLDIGCGWGGLALYLARRYG--VRVTGVTLSPEQLEYArerAAEAGLADRVEVRLADYRdLPADGQFDA 121

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1705230454 168 VYVNFALDH-PAAAWVDQ-------LAPGGRLLF 193
Cdd:COG2230   122 IVSIGMFEHvGPENYPAYfakvarlLKPGGRLLL 155
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 97-171 6.40e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 43.21  E-value: 6.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  97 VRPGERVAHLGAGTGyytaILAELV---GPSGHVTAVEYDGELAGKAA-GALHNR--ANVTVIHGD----ALVFPQAAVD 166
Cdd:COG4123    35 VKKGGRVLDLGTGTG----VIALMLaqrSPGARITGVEIQPEAAELARrNVALNGleDRITVIHGDlkefAAELPPGSFD 110


                  ....*
gi 1705230454 167 VVYVN 171
Cdd:COG4123   111 LVVSN 115
arsM PRK11873
arsenite methyltransferase;
91-191 1.18e-04

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 42.63  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  91 ALNQLgvRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKA------AGAlhnrANVTVIHGD--ALVFPQ 162
Cdd:PRK11873   71 ALAEL--KPGETVLDLGSGGGFDCFLAARRVGPTGKVIGVDMTPEMLAKAranarkAGY----TNVEFRLGEieALPVAD 144

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1705230454 163 AAVDVV----YVNFALDHPAA---AW-VdqLAPGGRL 191
Cdd:PRK11873  145 NSVDVIisncVINLSPDKERVfkeAFrV--LKPGGRF 179
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 94-191 1.81e-04

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 42.09  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  94 QLGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGALHNRA---NVTVIHGDA--LVFPQ---AAV 165
Cdd:pfam08704  35 MLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADKAREEFREHGidqLVTVTHRDVckEGFLTevsGKA 114

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1705230454 166 DVVYVNF-----ALDHPAAAWVDQlapGGRL 191
Cdd:pfam08704 115 DAVFLDLpspweAVPHAWKALKVE---GGRF 142
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
91-158 1.94e-04

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 42.20  E-value: 1.94e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1705230454  91 ALNQLGVRPGERVAHLGAGTGYYTAILAELVGPsghVTAVEYDGELAGKAAGALHNRANVTVIHGDAL 158
Cdd:PRK14896   21 IVEYAEDTDGDPVLEIGPGKGALTDELAKRAKK---VYAIELDPRLAEFLRDDEIAAGNVEIIEGDAL 85
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
96-192 2.13e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 41.66  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  96 GVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGALHNRA--NVTVIHGDA--LVFPQAAVDVVYVN 171
Cdd:pfam01209  39 GVKRGNKFLDVAGGTGDWTFGLSDSAGSSGKVVGLDINENMLKEGEKKAKEEGkyNIEFLQGNAeeLPFEDDSFDIVTIS 118

                          90       100
                  ....*....|....*....|....*..
gi 1705230454 172 FAL----DHPAA--AWVDQLAPGGRLL 192
Cdd:pfam01209 119 FGLrnfpDYLKVlkEAFRVLKPGGRVV 145
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
92-157 2.21e-04

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 41.35  E-value: 2.21e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1705230454  92 LNQLGVRPGERVAHLGAGTGYYT-AILAELVgPSGHVTAVEYDGELAGKaagaLHNR-ANVTVIHGDA 157
Cdd:COG3963    38 ASEVDWSGAGPVVELGPGTGVFTrAILARGV-PDARLLAVEINPEFAEH----LRRRfPRVTVVNGDA 100
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
87-171 3.48e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 40.66  E-value: 3.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  87 LHAGALNqlGVRPGERVAHLGAGTGYYtAILAELVGPSgHVTAVEYD---GELAGKAAGALHNRANvtVIHGDALVFP-Q 162
Cdd:COG2263    35 LHLAYLR--GDIEGKTVLDLGCGTGML-AIGAALLGAK-KVVGVDIDpeaLEIARENAERLGVRVD--FIRADVTRIPlG 108


                  ....*....
gi 1705230454 163 AAVDVVYVN 171
Cdd:COG2263   109 GSVDTVVMN 117
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 91-158 5.30e-04

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 40.17  E-value: 5.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1705230454  91 ALNQLGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDG---ELAGKAAGALHNRANVTVIHGDAL 158
Cdd:PRK00377   32 ALSKLRLRKGDMILDIGCGTGSVTVEASLLVGETGKVYAVDKDEkaiNLTRRNAEKFGVLNNIVLIKGEAP 102
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 91-157 7.85e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 40.54  E-value: 7.85e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  91 ALNQLGVRPGERVAHLGAGTGyYTAILAELVGPSGHVTAVEYDGE---LAGKAAGAlHNRANVTVIHGDA 157
Cdd:COG2242   239 TLAKLALRPGDVLWDIGAGSG-SVSIEAARLAPGGRVYAIERDPEraaLIRANARR-FGVPNVEVVEGEA 306
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 92-193 1.70e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 39.29  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  92 LNQLGVRPGERVAHLGAGTGYYTAILAELvGPSGHVTAVEYDGELAgKAAGALHNRANVtvihGDALVF-PQAAVDVVYV 170
Cdd:PRK14103   22 LARVGAERARRVVDLGCGPGNLTRYLARR-WPGAVIEALDSSPEMV-AAARERGVDART----GDVRDWkPKPDTDVVVS 95

                          90       100
                  ....*....|....*....|....*....
gi 1705230454 171 NFAL----DHPA--AAWVDQLAPGGRLLF 193
Cdd:PRK14103   96 NAALqwvpEHADllVRWVDELAPGSWIAV 124
PTZ00146 PTZ00146
fibrillarin; Provisional
 90-173 2.13e-03

fibrillarin; Provisional


Pssm-ID: 240291  Cd Length: 293  Bit Score: 38.95  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  90 GALNQLGVRPGERVAHLGAGTGYYTAILAELVGPSGHVTAVEYDGELAGKAAGALHNRANVTVIHGDALvFPQ------A 163
Cdd:PTZ00146  123 GGVANIPIKPGSKVLYLGAASGTTVSHVSDLVGPEGVVYAVEFSHRSGRDLTNMAKKRPNIVPIIEDAR-YPQkyrmlvP 201

                          90
                  ....*....|
gi 1705230454 164 AVDVVYVNFA 173
Cdd:PTZ00146  202 MVDVIFADVA 211
PRK14967 PRK14967
putative methyltransferase; Provisional
 87-171 5.37e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 37.34  E-value: 5.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  87 LHAGALNQLGVRPGERVAHLGAGTGyYTAILAELVGpSGHVTAVEYDGELAGKA-AGALHNRANVTVIHGD-ALVFPQAA 164
Cdd:PRK14967   24 LLADALAAEGLGPGRRVLDLCTGSG-ALAVAAAAAG-AGSVTAVDISRRAVRSArLNALLAGVDVDVRRGDwARAVEFRP 101


                  ....*..
gi 1705230454 165 VDVVYVN 171
Cdd:PRK14967  102 FDVVVSN 108
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
92-207 5.50e-03

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 37.28  E-value: 5.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  92 LNQLGVRPGERVAHLGAGTGYyTAILAELVGPSGHVTAVEYDGELAGKAAgalHNRA-----NVTVIHGDA-LVFPQAAV 165
Cdd:PRK07402   33 ISQLRLEPDSVLWDIGAGTGT-IPVEAGLLCPKGRVIAIERDEEVVNLIR---RNCDrfgvkNVEVIEGSApECLAQLAP 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1705230454 166 DVVYVNFALDHP-----AAAWvDQLAPGGRLLfplgipARSANGEQL 207
Cdd:PRK07402  109 APDRVCIEGGRPikeilQAVW-QYLKPGGRLV------ATASSLEGL 148
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 92-193 8.49e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.41  E-value: 8.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705230454  92 LNQLGVRPGERVAHLGAGTGYYTAILAELvGPSGHVTAVEYDG---ELAgKAAGALHNRANVTVIHGDALV-FPQAAVDV 167
Cdd:pfam05175  24 LEHLPKDLSGKVLDLGCGAGVLGAALAKE-SPDAELTMVDINAralESA-RENLAANGLENGEVVASDVYSgVEDGKFDL 101

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1705230454 168 VYVN--F---ALDHPAAAW------VDQLAPGGRLLF 193
Cdd:pfam05175 102 IISNppFhagLATTYNVAQrfiadaKRHLRPGGELWI 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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