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Conserved domains on  [gi|1705231073|ref|WP_142587446|]
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transglutaminase family protein [Pseudorhizobium halotolerans]

Protein Classification

transglutaminase family protein( domain architecture ID 12090973)

transglutaminase family protein may act as a cysteine protease

CATH:  3.10.620.30|2.60.40.2250

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YebA COG1305
Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, ...
 102-218 5.72e-35

Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440916 [Multi-domain]  Cd Length: 174  Bit Score: 123.58  E-value: 5.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705231073 102 RQPTALSRPGPATEAVVALV-----PAASDLERLHELMRLVGERVAYTIGATDAVTTAEEALAKGQGVCQDHSHVFIAAA 176
Cdd:COG1305    48 LAGPGELLSASYDPELRALAaeltgGATTPYEKARALYDWVRDNIRYDPGSTGVGTTALETLERRRGVCRDFAHLLVALL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1705231073 177 RLLGFPARYVSGYL---NLDAIDAQTATHAWAEAHVEGLGWIGFD 218
Cdd:COG1305   128 RALGIPARYVSGYLpgePPPGGGRADDAHAWVEVYLPGAGWVPFD 172
Bact_transglu_N pfam08379
Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus ...
 3-81 5.02e-21

Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus of various archaeal and bacterial hypothetical proteins. Some of these are annotated as being transglutaminase-like proteins, and in fact contain a transglutaminase-like superfamily domain (pfam01841).


:

Pssm-ID: 462455  Cd Length: 80  Bit Score: 84.13  E-value: 5.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705231073   3 LRIAHSTEYHYDAPLTYSLQRLRLVPRSSALQTVIDWNISIDGAKVEVT-YDDSFGNTTWLLSVDGEPHRIAIHASGTVE 81
Cdd:pfam08379   1 YRIRHRTRYRYDEPVSLSPHRLRLRPRSHPGQRVLSYSLDISPEPAARRwRRDAFGNRVARFSFDEPHTELVITAESEVE 80
 
Name Accession Description Interval E-value
YebA COG1305
Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, ...
 102-218 5.72e-35

Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440916 [Multi-domain]  Cd Length: 174  Bit Score: 123.58  E-value: 5.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705231073 102 RQPTALSRPGPATEAVVALV-----PAASDLERLHELMRLVGERVAYTIGATDAVTTAEEALAKGQGVCQDHSHVFIAAA 176
Cdd:COG1305    48 LAGPGELLSASYDPELRALAaeltgGATTPYEKARALYDWVRDNIRYDPGSTGVGTTALETLERRRGVCRDFAHLLVALL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1705231073 177 RLLGFPARYVSGYL---NLDAIDAQTATHAWAEAHVEGLGWIGFD 218
Cdd:COG1305   128 RALGIPARYVSGYLpgePPPGGGRADDAHAWVEVYLPGAGWVPFD 172
Transglut_core pfam01841
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 122-218 2.01e-23

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


Pssm-ID: 376628 [Multi-domain]  Cd Length: 108  Bit Score: 91.31  E-value: 2.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705231073 122 PAASDLERLHELMRLVGERVAYT-IGATDAVTTAEEALAKGQGVCQDHSHVFIAAARLLGFPARYVSGYLNLDAIDAQTA 200
Cdd:pfam01841  10 GATDPLEKARAIYDYVRKNITYDlPGRSPGDGDAEEFLFTGKGDCEDFASLFVALLRALGIPARYVTGYLRGPDTVRGGD 89

                          90
                  ....*....|....*...
gi 1705231073 201 THAWAEAHVEGLGWIGFD 218
Cdd:pfam01841  90 AHAWVEVYLPGYGWVPVD 107
Bact_transglu_N pfam08379
Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus ...
 3-81 5.02e-21

Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus of various archaeal and bacterial hypothetical proteins. Some of these are annotated as being transglutaminase-like proteins, and in fact contain a transglutaminase-like superfamily domain (pfam01841).


Pssm-ID: 462455  Cd Length: 80  Bit Score: 84.13  E-value: 5.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705231073   3 LRIAHSTEYHYDAPLTYSLQRLRLVPRSSALQTVIDWNISIDGAKVEVT-YDDSFGNTTWLLSVDGEPHRIAIHASGTVE 81
Cdd:pfam08379   1 YRIRHRTRYRYDEPVSLSPHRLRLRPRSHPGQRVLSYSLDISPEPAARRwRRDAFGNRVARFSFDEPHTELVITAESEVE 80
TGc smart00460
Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish ...
 157-221 1.80e-14

Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events.


Pssm-ID: 214673  Cd Length: 68  Bit Score: 66.64  E-value: 1.80e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1705231073  157 ALAKGQGVCQDHSHVFIAAARLLGFPARYVSGYL----NLDAIDAQTATHAWAEAHVEGlGWIGFDCSN 221
Cdd:smart00460   1 LLKTKYGTCGEFAALFVALLRSLGIPARVVSGYLkapdTIGGLRSIWEAHAWAEVYLEG-GWVPVDPTP 68
 
Name Accession Description Interval E-value
YebA COG1305
Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, ...
 102-218 5.72e-35

Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440916 [Multi-domain]  Cd Length: 174  Bit Score: 123.58  E-value: 5.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705231073 102 RQPTALSRPGPATEAVVALV-----PAASDLERLHELMRLVGERVAYTIGATDAVTTAEEALAKGQGVCQDHSHVFIAAA 176
Cdd:COG1305    48 LAGPGELLSASYDPELRALAaeltgGATTPYEKARALYDWVRDNIRYDPGSTGVGTTALETLERRRGVCRDFAHLLVALL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1705231073 177 RLLGFPARYVSGYL---NLDAIDAQTATHAWAEAHVEGLGWIGFD 218
Cdd:COG1305   128 RALGIPARYVSGYLpgePPPGGGRADDAHAWVEVYLPGAGWVPFD 172
Transglut_core pfam01841
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 122-218 2.01e-23

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


Pssm-ID: 376628 [Multi-domain]  Cd Length: 108  Bit Score: 91.31  E-value: 2.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705231073 122 PAASDLERLHELMRLVGERVAYT-IGATDAVTTAEEALAKGQGVCQDHSHVFIAAARLLGFPARYVSGYLNLDAIDAQTA 200
Cdd:pfam01841  10 GATDPLEKARAIYDYVRKNITYDlPGRSPGDGDAEEFLFTGKGDCEDFASLFVALLRALGIPARYVTGYLRGPDTVRGGD 89

                          90
                  ....*....|....*...
gi 1705231073 201 THAWAEAHVEGLGWIGFD 218
Cdd:pfam01841  90 AHAWVEVYLPGYGWVPVD 107
Bact_transglu_N pfam08379
Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus ...
 3-81 5.02e-21

Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus of various archaeal and bacterial hypothetical proteins. Some of these are annotated as being transglutaminase-like proteins, and in fact contain a transglutaminase-like superfamily domain (pfam01841).


Pssm-ID: 462455  Cd Length: 80  Bit Score: 84.13  E-value: 5.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705231073   3 LRIAHSTEYHYDAPLTYSLQRLRLVPRSSALQTVIDWNISIDGAKVEVT-YDDSFGNTTWLLSVDGEPHRIAIHASGTVE 81
Cdd:pfam08379   1 YRIRHRTRYRYDEPVSLSPHRLRLRPRSHPGQRVLSYSLDISPEPAARRwRRDAFGNRVARFSFDEPHTELVITAESEVE 80
TGc smart00460
Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish ...
 157-221 1.80e-14

Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events.


Pssm-ID: 214673  Cd Length: 68  Bit Score: 66.64  E-value: 1.80e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1705231073  157 ALAKGQGVCQDHSHVFIAAARLLGFPARYVSGYL----NLDAIDAQTATHAWAEAHVEGlGWIGFDCSN 221
Cdd:smart00460   1 LLKTKYGTCGEFAALFVALLRSLGIPARVVSGYLkapdTIGGLRSIWEAHAWAEVYLEG-GWVPVDPTP 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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