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Conserved domains on  [gi|1706990502|ref|WP_142962169|]
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MULTISPECIES: carboxymuconolactone decarboxylase family protein [Enterobacteriaceae]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 11450212)

carboxymuconolactone decarboxylase family protein similar to Escherichia coli protein YnjA and Bacillus subtilis protein YdfG

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4002925

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 12-144 8.13e-50

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


:

Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 156.58  E-value: 8.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706990502  12 PALAKTLADASMAL-GKISLDKKLKHLVDIRASQLNHCAFCLDMHVKEAKMHGERELRLYHVAIWRESPLFSAKEKAALA 90
Cdd:COG2128     3 PELLKAFLALSGALmAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAALA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1706990502  91 LTEALTRIGDnGVSEALYNELREHFSEVEVSELTFTVAVINAWNRLQILSQMAP 144
Cdd:COG2128    83 FAEALTRTPG-GVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGTPP 135
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 12-144 8.13e-50

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 156.58  E-value: 8.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706990502  12 PALAKTLADASMAL-GKISLDKKLKHLVDIRASQLNHCAFCLDMHVKEAKMHGERELRLYHVAIWRESPLFSAKEKAALA 90
Cdd:COG2128     3 PELLKAFLALSGALmAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAALA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1706990502  91 LTEALTRIGDnGVSEALYNELREHFSEVEVSELTFTVAVINAWNRLQILSQMAP 144
Cdd:COG2128    83 FAEALTRTPG-GVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGTPP 135
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 12-94 4.82e-16

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 68.49  E-value: 4.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706990502  12 PALAKTLADASMALGKIS-LDKKLKHLVDIRASQLNHCAFCLDMHVKEAKMHGERELRLYHVAIWRESPLFSAKEKAALA 90
Cdd:pfam02627   1 PELLAALTALAFGLLWDGgLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80


                  ....
gi 1706990502  91 LTEA 94
Cdd:pfam02627  81 AAEE 84
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 29-77 2.59e-11

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 55.45  E-value: 2.59e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1706990502  29 SLDKKLKHLVDIRASQLNHCAFCLDMHVKEAKMHGERELRLYHVAIWRE 77
Cdd:TIGR00778   2 ALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWAA 50
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 12-144 8.13e-50

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 156.58  E-value: 8.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706990502  12 PALAKTLADASMAL-GKISLDKKLKHLVDIRASQLNHCAFCLDMHVKEAKMHGERELRLYHVAIWRESPLFSAKEKAALA 90
Cdd:COG2128     3 PELLKAFLALSGALmAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAALA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1706990502  91 LTEALTRIGDnGVSEALYNELREHFSEVEVSELTFTVAVINAWNRLQILSQMAP 144
Cdd:COG2128    83 FAEALTRTPG-GVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGTPP 135
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 12-94 4.82e-16

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 68.49  E-value: 4.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706990502  12 PALAKTLADASMALGKIS-LDKKLKHLVDIRASQLNHCAFCLDMHVKEAKMHGERELRLYHVAIWRESPLFSAKEKAALA 90
Cdd:pfam02627   1 PELLAALTALAFGLLWDGgLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80


                  ....
gi 1706990502  91 LTEA 94
Cdd:pfam02627  81 AAEE 84
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 29-77 2.59e-11

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 55.45  E-value: 2.59e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1706990502  29 SLDKKLKHLVDIRASQLNHCAFCLDMHVKEAKMHGERELRLYHVAIWRE 77
Cdd:TIGR00778   2 ALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWAA 50
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 13-138 3.78e-05

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 41.63  E-value: 3.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706990502  13 ALAKTLADASMALGKISLDKKLKHLVDIRASQLNHCAFCLDMHVKEAKMHGERELRLYHVAIWRESPLFSAKEKAALALT 92
Cdd:TIGR01926  43 LRARTAYFNDLMLGEGGLSRAERELIAVVVSRANGCVYCAAVHGAALRQLSGDPDLADAVAVNFRDADLSPRERAMLDFA 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1706990502  93 EALTRIGDNgVSEALYNELREH-FSEVEVSELTFTVAVINAWNRLQI 138
Cdd:TIGR01926 123 VKLTATPAK-VNEADFAALRAAgFSDLDILDLIHSVAFFNWANRLML 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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