Adenylyl/Guanylyl and SMODS C-terminal sensor domain; Predicted to function as a sensor domain, ...
702-835
6.60e-34
Adenylyl/Guanylyl and SMODS C-terminal sensor domain; Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by bacterial adenylyl/guanylyl cyclase domains. The sensing of ligands by AGS-C is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.
:
Pssm-ID: 436297 Cd Length: 129 Bit Score: 126.19 E-value: 6.60e-34
SMODS-associated and fused to various effectors sensor domain; Predicted to function as a ...
159-354
2.70e-23
SMODS-associated and fused to various effectors sensor domain; Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. This domain has been characterized in CD-NTase-associated protein 4 (Cap4), the founding member of a major family of downstream receptors that specifically respond to nucleotide second messenger signals in CBASS immunity, a bacterial system that provides immunity against bacteriophage. SAVED exhibits divergence in its nucleotide binding pocket which enables the recognition of a wide range of CD-NTase products such as bacterial second messengers with alternative ring size, nucleobase, and 3'-5' or 2'-5' phosphodiester linkages. The sensing of ligands by SAVED activates effectors that are essential for CBASS-mediated protection of bacteria from phage infection.
:
Pssm-ID: 436306 Cd Length: 190 Bit Score: 98.15 E-value: 2.70e-23
Adenylyl/Guanylyl and SMODS C-terminal sensor domain; Predicted to function as a sensor domain, ...
702-835
6.60e-34
Adenylyl/Guanylyl and SMODS C-terminal sensor domain; Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by bacterial adenylyl/guanylyl cyclase domains. The sensing of ligands by AGS-C is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.
Pssm-ID: 436297 Cd Length: 129 Bit Score: 126.19 E-value: 6.60e-34
SMODS-associated and fused to various effectors sensor domain; Predicted to function as a ...
159-354
2.70e-23
SMODS-associated and fused to various effectors sensor domain; Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. This domain has been characterized in CD-NTase-associated protein 4 (Cap4), the founding member of a major family of downstream receptors that specifically respond to nucleotide second messenger signals in CBASS immunity, a bacterial system that provides immunity against bacteriophage. SAVED exhibits divergence in its nucleotide binding pocket which enables the recognition of a wide range of CD-NTase products such as bacterial second messengers with alternative ring size, nucleobase, and 3'-5' or 2'-5' phosphodiester linkages. The sensing of ligands by SAVED activates effectors that are essential for CBASS-mediated protection of bacteria from phage infection.
Pssm-ID: 436306 Cd Length: 190 Bit Score: 98.15 E-value: 2.70e-23
SAVED domain; The SAVED (SMODS-Associated and fused to Various Effector Domains) domain is ...
103-357
1.18e-21
SAVED domain; The SAVED (SMODS-Associated and fused to Various Effector Domains) domain is predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. The sensing of ligands by SAVED is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.
Pssm-ID: 468112 Cd Length: 261 Bit Score: 95.23 E-value: 1.18e-21
Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class ...
421-542
5.37e-08
Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; In vertebrates, 2-5OASs are induced by interferon during the innate immune response to protect against RNA virus infections. In the presence of an RNA activator, 2-5OASs catalyze the oligomerization of ATP into 2-5A. 2-5A activates endoribonuclease L, which leads to degradation of the viral RNA. 2-5OASs are also implicated in cell growth control, differentiation, and apoptosis. This family includes human OAS1, -2, -3, and OASL. CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This class I group includes the archaeal Sulfolobus shibatae and Archeoglobus fulgidus CCA-adding enzymes. It belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this family.
Pssm-ID: 143390 [Multi-domain] Cd Length: 143 Bit Score: 52.79 E-value: 5.37e-08
Second Messenger Oligonucleotide or Dinucleotide Synthetase domain; Nucleotide synthetase ...
377-542
3.14e-05
Second Messenger Oligonucleotide or Dinucleotide Synthetase domain; Nucleotide synthetase enzyme of the DNA polymerase beta superfamily. Experimental studies have demonstrated cGAMP synthetase activity in the Vibrio cholerae DncV protein, a member of the SMODS family. The diversity inherent to the SMODS family suggests members of the family could generate a range of nucleotides, cyclic and/or linear. The nucleotide second messengers generated by the SMODS domains are predicted to activate effectors in a class of conflict systems reliant on the production and sensing of the nucleotide second messengers.
Pssm-ID: 436305 Cd Length: 164 Bit Score: 44.94 E-value: 3.14e-05
Adenylyl/Guanylyl and SMODS C-terminal sensor domain; Predicted to function as a sensor domain, ...
702-835
6.60e-34
Adenylyl/Guanylyl and SMODS C-terminal sensor domain; Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by bacterial adenylyl/guanylyl cyclase domains. The sensing of ligands by AGS-C is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.
Pssm-ID: 436297 Cd Length: 129 Bit Score: 126.19 E-value: 6.60e-34
SMODS-associated and fused to various effectors sensor domain; Predicted to function as a ...
159-354
2.70e-23
SMODS-associated and fused to various effectors sensor domain; Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. This domain has been characterized in CD-NTase-associated protein 4 (Cap4), the founding member of a major family of downstream receptors that specifically respond to nucleotide second messenger signals in CBASS immunity, a bacterial system that provides immunity against bacteriophage. SAVED exhibits divergence in its nucleotide binding pocket which enables the recognition of a wide range of CD-NTase products such as bacterial second messengers with alternative ring size, nucleobase, and 3'-5' or 2'-5' phosphodiester linkages. The sensing of ligands by SAVED activates effectors that are essential for CBASS-mediated protection of bacteria from phage infection.
Pssm-ID: 436306 Cd Length: 190 Bit Score: 98.15 E-value: 2.70e-23
SAVED domain; The SAVED (SMODS-Associated and fused to Various Effector Domains) domain is ...
103-357
1.18e-21
SAVED domain; The SAVED (SMODS-Associated and fused to Various Effector Domains) domain is predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. The sensing of ligands by SAVED is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.
Pssm-ID: 468112 Cd Length: 261 Bit Score: 95.23 E-value: 1.18e-21
Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class ...
421-542
5.37e-08
Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; In vertebrates, 2-5OASs are induced by interferon during the innate immune response to protect against RNA virus infections. In the presence of an RNA activator, 2-5OASs catalyze the oligomerization of ATP into 2-5A. 2-5A activates endoribonuclease L, which leads to degradation of the viral RNA. 2-5OASs are also implicated in cell growth control, differentiation, and apoptosis. This family includes human OAS1, -2, -3, and OASL. CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This class I group includes the archaeal Sulfolobus shibatae and Archeoglobus fulgidus CCA-adding enzymes. It belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this family.
Pssm-ID: 143390 [Multi-domain] Cd Length: 143 Bit Score: 52.79 E-value: 5.37e-08
Second Messenger Oligonucleotide or Dinucleotide Synthetase domain; Nucleotide synthetase ...
377-542
3.14e-05
Second Messenger Oligonucleotide or Dinucleotide Synthetase domain; Nucleotide synthetase enzyme of the DNA polymerase beta superfamily. Experimental studies have demonstrated cGAMP synthetase activity in the Vibrio cholerae DncV protein, a member of the SMODS family. The diversity inherent to the SMODS family suggests members of the family could generate a range of nucleotides, cyclic and/or linear. The nucleotide second messengers generated by the SMODS domains are predicted to activate effectors in a class of conflict systems reliant on the production and sensing of the nucleotide second messengers.
Pssm-ID: 436305 Cd Length: 164 Bit Score: 44.94 E-value: 3.14e-05
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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