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Conserved domains on  [gi|1716884370|ref|WP_144168287|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Shewanella]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
15-202 1.86e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.47  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1716884370  15 RDALIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAMVRDTIAPVLEAFKhynaaqshqstsegSAN 94
Cdd:COG1309     8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALE--------------EAL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1716884370  95 SPEPNNSRLEpskmsldsskkrpesgfggpfELMQVYYRAMAANPALPGLIIqvlnhrEGSEAFDALASVFSDMLSRSKL 174
Cdd:COG1309    74 AAEDPRERLR---------------------ALLRAYLEFLAENPALARLLL------AEAAELPELRAALRALLRRLRA 126

                         170       180
                  ....*....|....*....|....*...
gi 1716884370 175 WIRQLGQDHGLNPNLDPTLARLSFVSLM 202
Cdd:COG1309   127 LLAELLRAGGLLADVDPDALARALLALL 154
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
15-202 1.86e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.47  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1716884370  15 RDALIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAMVRDTIAPVLEAFKhynaaqshqstsegSAN 94
Cdd:COG1309     8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALE--------------EAL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1716884370  95 SPEPNNSRLEpskmsldsskkrpesgfggpfELMQVYYRAMAANPALPGLIIqvlnhrEGSEAFDALASVFSDMLSRSKL 174
Cdd:COG1309    74 AAEDPRERLR---------------------ALLRAYLEFLAENPALARLLL------AEAAELPELRAALRALLRRLRA 126

                         170       180
                  ....*....|....*....|....*...
gi 1716884370 175 WIRQLGQDHGLNPNLDPTLARLSFVSLM 202
Cdd:COG1309   127 LLAELLRAGGLLADVDPDALARALLALL 154
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 15-65 5.12e-13

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 65.63  E-value: 5.12e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1716884370  15 RDALIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAMV 65
Cdd:NF037937    1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLLEYLV 51
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
18-64 1.95e-12

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 60.11  E-value: 1.95e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1716884370  18 LIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAM 64
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 1-69 4.73e-08

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 51.98  E-value: 4.73e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1716884370   1 MKATAGRPKGHSgARDALIEAARSCFTLKGYErVSTRELARKAGVDAAMIRYYFGSKAGLFEAMVR---DTI 69
Cdd:PRK11552    2 MNNPAMTTRGEQ-AKQQLIAAALAQFGEYGLH-ATTRDIAAQAGQNIAAITYYFGSKEDLYLAVAQwiaDFI 71
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
15-202 1.86e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.47  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1716884370  15 RDALIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAMVRDTIAPVLEAFKhynaaqshqstsegSAN 94
Cdd:COG1309     8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALE--------------EAL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1716884370  95 SPEPNNSRLEpskmsldsskkrpesgfggpfELMQVYYRAMAANPALPGLIIqvlnhrEGSEAFDALASVFSDMLSRSKL 174
Cdd:COG1309    74 AAEDPRERLR---------------------ALLRAYLEFLAENPALARLLL------AEAAELPELRAALRALLRRLRA 126

                         170       180
                  ....*....|....*....|....*...
gi 1716884370 175 WIRQLGQDHGLNPNLDPTLARLSFVSLM 202
Cdd:COG1309   127 LLAELLRAGGLLADVDPDALARALLALL 154
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 15-65 5.12e-13

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 65.63  E-value: 5.12e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1716884370  15 RDALIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAMV 65
Cdd:NF037937    1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLLEYLV 51
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
18-64 1.95e-12

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 60.11  E-value: 1.95e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1716884370  18 LIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAM 64
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 1-69 4.73e-08

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 51.98  E-value: 4.73e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1716884370   1 MKATAGRPKGHSgARDALIEAARSCFTLKGYErVSTRELARKAGVDAAMIRYYFGSKAGLFEAMVR---DTI 69
Cdd:PRK11552    2 MNNPAMTTRGEQ-AKQQLIAAALAQFGEYGLH-ATTRDIAAQAGQNIAAITYYFGSKEDLYLAVAQwiaDFI 71
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 15-67 2.87e-05

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 43.68  E-value: 2.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1716884370  15 RDALIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAMVRD 67
Cdd:PRK00767   11 RQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRH 63
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
6-66 3.74e-05

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 43.39  E-value: 3.74e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1716884370   6 GRPKGHSGARDALIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAMVR 66
Cdd:COG3226     1 PRRRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFE 61
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 2-77 6.09e-04

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 39.91  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1716884370   2 KATAGRPKGHSGARDALIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAMVRDT----IAPvLEAFK 77
Cdd:PRK15008    7 KTTGKRSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQIldiwLAP-LKAFR 85
PRK05472 PRK05472
redox-sensing transcriptional repressor Rex; Provisional
 29-56 1.43e-03

redox-sensing transcriptional repressor Rex; Provisional


Pssm-ID: 235486 [Multi-domain]  Cd Length: 213  Bit Score: 38.94  E-value: 1.43e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1716884370  29 KGYERVSTRELARKAGVDAAMIR---YYFGS 56
Cdd:PRK05472   28 EGVERVSSKELAEALGVDSAQIRkdlSYFGE 58
Put_DNA-bind_N pfam06971
Putative DNA-binding protein N-terminus; This family represents the N-terminus (approximately ...
 29-51 1.61e-03

Putative DNA-binding protein N-terminus; This family represents the N-terminus (approximately 50 residues) of a number of putative bacterial DNA-binding proteins.


Pssm-ID: 429222 [Multi-domain]  Cd Length: 49  Bit Score: 35.50  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|...
gi 1716884370  29 KGYERVSTRELARKAGVDAAMIR 51
Cdd:pfam06971  23 EGVERISSTELAEALGVTAAQVR 45
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 15-73 1.93e-03

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 38.57  E-value: 1.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1716884370  15 RDALIEAARSCFTLKGYERVSTRELARKAGVDAAMIRYYFGSKAGLFEAM------VRDTIAPVL 73
Cdd:PRK09975   13 RQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMwlqqppLRELIQEHL 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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