|
Name |
Accession |
Description |
Interval |
E-value |
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
8-444 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 766.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 8 TPDAWGFSTAQVHAGVAVGQhAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVG 87
Cdd:COG2873 2 TEKKYGFETLALHAGQEPDP-TTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 88 ALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGN 167
Cdd:COG2873 81 ALATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFV-DPDDPEAFEAAIDPNTKAIFGETIGN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 168 PRGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYAQhAERYPG 247
Cdd:COG2873 160 PALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGGNFDWAA-NGKFPE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 248 FNEPDESYHGLVYARDLGvgsplgaNLAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEG 327
Cdd:COG2873 239 LTEPDPSYHGLVYTEAFG-------NAAFITKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 328 RDDVEHVVYAGLESSPWHERAQRYLPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTD 407
Cdd:COG2873 312 HPKVAWVNYPGLPSHPYHELAQKYLPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSE 391
|
410 420 430
....*....|....*....|....*....|....*..
gi 1718407979 408 DEQRAAGVTPGLVRLSLGVEDIEDILADLERGFAAAA 444
Cdd:COG2873 392 EEQAAAGVTPDLIRLSVGIEDIDDIIADLDQALAAAT 428
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
1-445 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 703.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 1 MTDQTTPTPDAWGFSTAQVHAGvAVGQHAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIA 80
Cdd:PRK07812 1 STSTDADPTANWSFETKQIHAG-QTPDPATNARALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 81 ALEGGVGALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVTDPDDLESWRAAVRPNTKAF 160
Cdd:PRK07812 80 ALEGGVAALLLASGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVEDPDDLDAWRAAVRPNTKAF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 161 FGETLGNPRGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYAQ 240
Cdd:PRK07812 160 FAETISNPQIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDWTQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 241 haERYPGFNEPDESYHGLVYArDLGVGsplganlAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAA 320
Cdd:PRK07812 240 --GRFPGFTTPDPSYHGVVFA-ELGPP-------AYALKARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQR 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 321 VARWLEGRDDVEHVVYAGLESSPWHERAQRYLPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPAST 400
Cdd:PRK07812 310 VAEFLEARDEVASVNYAGLPSSPWYERAKRLAPKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPAST 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1718407979 401 THSQLTDDEQRAAGVTPGLVRLSLGVEDIEDILADLERGFAAAAR 445
Cdd:PRK07812 390 THSQLTPEEQLATGVTPGLVRLAVGIEGIDDILADLEAGFAAAKA 434
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
13-441 |
0e+00 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 644.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 13 GFSTAQVHAGvavgQHAFGAT---ALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGAL 89
Cdd:TIGR01326 1 HFETLQLHAG----QEPDPTTgsrAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 90 LLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPR 169
Cdd:TIGR01326 77 AVASGQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFV-DPDDPESLEKAIDENTKAVFAETIGNPQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 170 GDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYAQhaERYPGFN 249
Cdd:TIGR01326 156 INVLDIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKFDWNN--GRFPLFT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 250 EPDESYHGLVYARDLGvgsplgaNLAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRD 329
Cdd:TIGR01326 234 TPDPSYHGLVFTETLG-------NPAFILKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 330 DVEHVVYAGLESSPWHERAQRYLPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDE 409
Cdd:TIGR01326 307 DVAWVNYPGLASHPHHALAKKYLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEE 386
|
410 420 430
....*....|....*....|....*....|..
gi 1718407979 410 QRAAGVTPGLVRLSLGVEDIEDILADLERGFA 441
Cdd:TIGR01326 387 QLKAGVTPGLIRLSVGIENIDDIIADLEQALE 418
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
11-443 |
0e+00 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 533.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 11 AWGFSTAQVHAGVAVGQHAFgATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALL 90
Cdd:PRK08248 6 TFRLETLAIHAGQEIDPTTG-SRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 91 LASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRG 170
Cdd:PRK08248 85 VSSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFV-DPSDPENFEAAITDKTKALFAETIGNPKG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 171 DVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYAQhAERYPGFNE 250
Cdd:PRK08248 164 DVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFDWKG-SGKFPGLTE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 251 PDESYHGLVYARDLGvgsplgaNLAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDD 330
Cdd:PRK08248 243 PDPSYHGLVYTDAVG-------EAAYITKARVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 331 VEHVVYAGLESSPWHERAQRYLPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQ 410
Cdd:PRK08248 316 VEWVSYPGLPSHPSYELAKKYLPKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQ 395
|
410 420 430
....*....|....*....|....*....|...
gi 1718407979 411 RAAGVTPGLVRLSLGVEDIEDILADLERGFAAA 443
Cdd:PRK08248 396 LAAGVTPGLVRLSVGTEAIDDILDDLRQAIRQS 428
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
5-443 |
4.71e-178 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 504.63 E-value: 4.71e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 5 TTPTPdawGFSTAQVHAGvAVGQHAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEG 84
Cdd:PRK05994 2 TDRSP---GFATLAVHAG-AQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 85 GVGALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGET 164
Cdd:PRK05994 78 GTAALAVASGHAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWA-DADDPASFERAITPRTKAIFIES 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 165 LGNPRGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYAQHAeR 244
Cdd:PRK05994 157 IANPGGTVTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTFDWSKSG-K 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 245 YPGFNEPDESYHGLVYARDLGvgsplgaNLAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARW 324
Cdd:PRK05994 236 YPMLSEPRPEYHGLVLHETFG-------NFAFAIAARVLGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 325 LEGRDDVEHVVYAGLESSPWHERAQRYLPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQ 404
Cdd:PRK05994 309 LKGHPKVSWVNYAGLPDDPYHALAQKYSPKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQ 388
|
410 420 430
....*....|....*....|....*....|....*....
gi 1718407979 405 LTDDEQRAAGVTPGLVRLSLGVEDIEDILADLERGFAAA 443
Cdd:PRK05994 389 LTDEQKVAAGAGPDVVRLSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
7-447 |
1.82e-177 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 503.50 E-value: 1.82e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 7 PTPDAWGFSTAQVHAGvAVGQHAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGV 86
Cdd:PRK08134 2 PGMSPPGFDTLALHAG-AAPDPATGARAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 87 GALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLG 166
Cdd:PRK08134 81 GAIATASGQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFV-KPGDIDGWRAAIRPNTRLLFGETLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 167 NPRGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYaQHAERYP 246
Cdd:PRK08134 160 NPGLEVLDIPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRFDW-EASGKFP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 247 GFNEPDESYHGLVYARDLGVGsplganlAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLE 326
Cdd:PRK08134 239 ELTEPYAGFHGMVFAEESTVA-------AFLLRARREGLRDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 327 GRDDVEHVVYAGLESSPWHERAQRYLPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLT 406
Cdd:PRK08134 312 SHPAVARVAHPELESHPDHALAKRLLPRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMD 391
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1718407979 407 DDEQRAAGVTPGLVRLSLGVEDIEDILADLERGFAAAARRG 447
Cdd:PRK08134 392 AAALAAAGIGEGTIRLSIGLEDADDLIDDLKRALKAAEKAG 432
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
1-442 |
4.62e-177 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 502.48 E-value: 4.62e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 1 MTDQTTPTPDAWGFSTAQVHAGVAVGQHAfGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIA 80
Cdd:PRK05613 1 MPKYDNSNADQWGFETRSIHAGQSVDSDT-SARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 81 ALEGGVGALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVTDPDDLESWRAAVRPNTKAF 160
Cdd:PRK05613 80 SLEGGVHAVAFASGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVENPDDPESWQAAVQPNTKAF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 161 FGETLGNPRGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYAQ 240
Cdd:PRK05613 160 FGETFANPQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWTV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 241 haER-----YPGFNEPDESYHGLVYArDLGvgsplgaNLAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQV 315
Cdd:PRK05613 240 --ERdgkpvFPYFVTPDPAYHGLKYA-DLG-------APAFGLKARAGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHN 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 316 ANAAAVARWLEGRDDVEHVVYAGLESSPWHERAQRYLPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVV 395
Cdd:PRK05613 310 ENAIKVAEFLNNHEKVAKVNFAGLKDSPWYATKEKLGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVV 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1718407979 396 HPASTTHSQLTDDEQRAAGVTPGLVRLSLGVEDIEDILADLERGFAA 442
Cdd:PRK05613 390 HPATTTHSQSDEAGLARAGITQATVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
31-441 |
2.75e-162 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 462.44 E-value: 2.75e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 31 GATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGAGD 110
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 111 HVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVPLI 190
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFV-DPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 191 VDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTfdyaqhaerypgfnepdesyhglvyardlgvgspl 270
Cdd:cd00614 160 VDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGE----------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 271 ganlAFILKARVQLLRdYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHERAQR 350
Cdd:cd00614 205 ----ALIQRLRFLRLA-LGTILSPFDAWLLLRGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKK 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 351 YLpKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAGVTPGLVRLSLGVEDIE 430
Cdd:cd00614 280 QM-SGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVE 358
|
410
....*....|.
gi 1718407979 431 DILADLERGFA 441
Cdd:cd00614 359 DLIADLEQALK 369
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
12-443 |
1.65e-160 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 458.74 E-value: 1.65e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 12 WGFSTAQVHAGVAVGQHaFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLL 91
Cdd:COG0626 1 MGPATRAVHAGRDPDPQ-TGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 92 ASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGD 171
Cdd:COG0626 80 ASGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFV-DPTDLAAVEAAIRPNTKLVFLETPSNPTLE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 172 VLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagtfdyaqhaerypgfnep 251
Cdd:COG0626 159 VVDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVV-------------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 252 desyhglvyardlgvgsplgANLAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDV 331
Cdd:COG0626 219 --------------------GRDEELAERLRFLQNALGAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAV 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 332 EHVVYAGLESSPWHERAQRYLpKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQR 411
Cdd:COG0626 279 ARVYYPGLPSHPGHELAKRQM-SGFGGMLSFELKGGREAARRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERA 357
|
410 420 430
....*....|....*....|....*....|..
gi 1718407979 412 AAGVTPGLVRLSLGVEDIEDILADLERGFAAA 443
Cdd:COG0626 358 ALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
16-445 |
4.70e-156 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 448.97 E-value: 4.70e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 16 TAQVHAGVAvGQHAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLASGQ 95
Cdd:PRK06084 5 TLAIHAGYS-PDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 96 AATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDV 175
Cdd:PRK06084 84 AAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFA-AHDDIAALEALIDERTKAVFCESIGNPAGNIIDI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 176 RAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYAQHAERYPGFNEPDESY 255
Cdd:PRK06084 163 QALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWAEHKERFALLNTPDPSY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 256 HGLVYARDLGVGsplganlAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVV 335
Cdd:PRK06084 243 HGVTYTEAFGPA-------AFIGRCRVVPLRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 336 YAGLESSPWHERAQRYLPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAGV 415
Cdd:PRK06084 316 YAGLPDHPEHELARRYMGGKPASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGV 395
|
410 420 430
....*....|....*....|....*....|
gi 1718407979 416 TPGLVRLSLGVEDIEDILADLERGFAAAAR 445
Cdd:PRK06084 396 SRDMVRLSIGIEHIDDIIADLAQALDASKG 425
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
15-441 |
5.05e-149 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 428.96 E-value: 5.05e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 15 STAQVHAGVAVGQhAFGATALPIFQTTSYDFpsaqvaadRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLASG 94
Cdd:pfam01053 1 DTLAVHAGQRPDP-QTGAVSVPIYLTSTYVF--------DFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 95 QAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLD 174
Cdd:pfam01053 72 MAAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFV-DTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 175 VRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTfdyaqhaerypgfnepdes 254
Cdd:pfam01053 151 IEAIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGE------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 255 yhglvyardlgvgsPLGANLAFilkarvqLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHV 334
Cdd:pfam01053 212 --------------ELGKELYF-------LQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKV 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 335 VYAGLESSPWHERAQRYLpKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAG 414
Cdd:pfam01053 271 YYPGLPSHPGHELAKRQM-KGFGGMLSFELKGGLEAAKKFLDNLKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAG 349
|
410 420
....*....|....*....|....*..
gi 1718407979 415 VTPGLVRLSLGVEDIEDILADLERGFA 441
Cdd:pfam01053 350 ITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
10-450 |
3.23e-130 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 383.25 E-value: 3.23e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 10 DAWGFSTAQVHAGVAVGQHAfgATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGAL 89
Cdd:PRK06702 3 ESWGKGTICVQGGYTPKNGE--PRVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 90 LLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVTDPDDLESWRAAVRPNTKAFFGETLGNPR 169
Cdd:PRK06702 81 ATASGQAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNLTADEIVALANDKTKLVYAESLGNPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 170 GDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYAQHaeRYPGFN 249
Cdd:PRK06702 161 MNVLNFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGNFDWTNG--KYPELV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 250 EPDESYHGLVYARDLGVGsplganlAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRD 329
Cdd:PRK06702 239 EPDPSYHGVSYVQNFGAA-------AYIVKARVQLLRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 330 DVEHVVYAGLESSPWHERAQRYLPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDE 409
Cdd:PRK06702 312 RIEWVNYPGLDSNENYSLAQKYLKKGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAED 391
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1718407979 410 QRAAGVTPGLVRLSLGVEDIEDILADLERGFAAAARRGDDD 450
Cdd:PRK06702 392 QRLAGVTSDLIRLSVGIEDVSDIIADLEAALVGGKQHADHN 432
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
9-442 |
6.85e-129 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 378.19 E-value: 6.85e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 9 PDAWGFSTAQVHAGVAVGQhaFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGA 88
Cdd:PRK08133 2 DDSLGFDTLAVRAGQLRSP--FGEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEAC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 89 LLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNP 168
Cdd:PRK08133 80 VATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFV-DLTDLDAWRAAVRPNTKLFFLETPSNP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 169 RGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFdyaqhaerypgf 248
Cdd:PRK08133 159 LTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKEL------------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 249 nepdesyhglvyardlgvgsplganlafiLKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGR 328
Cdd:PRK08133 227 -----------------------------MEEVFGFLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAH 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 329 DDVEHVVYAGLESSPWHERAQRYlPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDD 408
Cdd:PRK08133 278 PGVERVFYPGLPSHPQHELAKRQ-QKGGGAIVSFEVKGGREAAWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPE 356
|
410 420 430
....*....|....*....|....*....|....
gi 1718407979 409 EQRAAGVTPGLVRLSLGVEDIEDILADLERGFAA 442
Cdd:PRK08133 357 ARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
13-439 |
4.19e-124 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 366.46 E-value: 4.19e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 13 GFSTAQVHAGvAVGQHAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLA 92
Cdd:PRK06234 8 GFATKAIHGG-HIGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 93 SGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDV 172
Cdd:PRK06234 87 SGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFV-DTSNLEEVRNALKANTKVVYLETPANPTLKV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 173 LDVRAVADAAHEA--GVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagtfdyaqhaerypgfne 250
Cdd:PRK06234 166 TDIKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVV------------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 251 pdesyhglvyardlgvgsplgANLAFILKARVQLLRDY-GSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRD 329
Cdd:PRK06234 227 ---------------------GKEEFINQVKLFGIKDMtGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHP 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 330 DVEHVVYAGLESSPWHERAQRYLpKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDE 409
Cdd:PRK06234 286 AVEKVYYPGLESFEYYELAKKQM-SLPGAMISFELKGGVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEE 364
|
410 420 430
....*....|....*....|....*....|
gi 1718407979 410 QRAAGVTPGLVRLSLGVEDIEDILADLERG 439
Cdd:PRK06234 365 RKEAGISDGLVRLSVGLEDVDDIIADLKQA 394
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
16-439 |
1.90e-110 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 331.04 E-value: 1.90e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 16 TAQVHAGVAvgQHAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLASGQ 95
Cdd:TIGR01325 2 TLAVRGGML--RSGFEETAEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 96 AATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDV 175
Cdd:TIGR01325 80 AAIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFV-DGTDLSAWEAALKPNTKAVFVETPSNPLQELVDI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 176 RAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGtfdyAQHAERYPGFnepdesy 255
Cdd:TIGR01325 159 AAVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSE----EYMDEPVQKL------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 256 hglvyardlgvgsplganlafilkarvqlLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVV 335
Cdd:TIGR01325 228 -----------------------------LRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVY 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 336 YAGLESSPWHERAQRYLpKGAGAFVSFEIaGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAGV 415
Cdd:TIGR01325 279 YPGLPSHPQHELAKRQM-SGGGTVVTFDL-DCRQAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGI 356
|
410 420
....*....|....*....|....
gi 1718407979 416 TPGLVRLSLGVEDIEDILADLERG 439
Cdd:TIGR01325 357 GDGLVRLSVGLEDVDDLIADIDRA 380
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
13-442 |
2.93e-104 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 315.67 E-value: 2.93e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 13 GFSTAQVHAGVAVGQHaFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLA 92
Cdd:TIGR01328 3 TFATRAIHAGYPPKDQ-FGALTPPIYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 93 SGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDV 172
Cdd:TIGR01328 82 SGMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFI-NMAIPEEVKAHIKDNTKIVYFETPANPTMKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 173 LDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIvdAGTFDYAQHAErypgfnepd 252
Cdd:TIGR01328 161 IDMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLI--CGKAELLQQIR--------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 253 esyhgLVYARDLGvgsplganlafilkarvqllrdyGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVE 332
Cdd:TIGR01328 230 -----MVGIKDMT-----------------------GSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVE 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 333 HVVYAGLESSPWHERAQRYLPKGaGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRA 412
Cdd:TIGR01328 282 KVYYPGFEDHPGHDIAAKQMRMG-GGMITFELKGGFAGAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREA 360
|
410 420 430
....*....|....*....|....*....|
gi 1718407979 413 AGVTPGLVRLSLGVEDIEDILADLERGFAA 442
Cdd:TIGR01328 361 AGITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
10-447 |
9.28e-104 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 314.43 E-value: 9.28e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 10 DAWGFSTAQVHAGVAVGQHAfGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGAL 89
Cdd:PRK07503 6 NNTGFSTRAIHHGYDPLDHG-GALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 90 LLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPR 169
Cdd:PRK07503 85 ALASGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHV-DLTDPAALKAAISDKTRMVYFETPANPN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 170 GDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagtfdyaqhaerypgfn 249
Cdd:PRK07503 164 MRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVV------------------ 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 250 epdesyhglvyardlgvgsplgANLAFILKARVQLLRDY-GSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGR 328
Cdd:PRK07503 226 ----------------------GGKALADRIRLEGLKDMtGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARH 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 329 DDVEHVVYAGLESSPWHERAQRYLPKGaGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDD 408
Cdd:PRK07503 284 PAVELVHYPGLPSFAQHALAQRQMALP-GGMIAFELKGGIAAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPE 362
|
410 420 430
....*....|....*....|....*....|....*....
gi 1718407979 409 EQRAAGVTPGLVRLSLGVEDIEDILADLERGFAAAARRG 447
Cdd:PRK07503 363 ERAEHGISEGLVRLSVGLEDVADILADLAQALDACAVAA 401
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
14-438 |
1.25e-94 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 290.59 E-value: 1.25e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 14 FSTAQVHAGVAVGQHaFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLAS 93
Cdd:PRK06767 6 METALIHHGYTSEEH-KGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFGS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 94 GQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFvTDPDDLESWRAAVRPNTKAFFGETLGNPRGDVL 173
Cdd:PRK06767 85 GMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSF-CDMETEADIENKIRPNTKLIFVETPINPTMKLI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 174 DVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagtfdyaqhaerypgfnepde 253
Cdd:PRK06767 164 DLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTI---------------------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 254 syhglvyardlgvgsplGANLAFILKARVqLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEH 333
Cdd:PRK06767 222 -----------------CKTRALAEKIRP-MRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEG 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 334 VVYaglessPWHERAQRYLPKGaGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAA 413
Cdd:PRK06767 284 VWY------PEGELASRQMKRG-GGVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEM 356
|
410 420
....*....|....*....|....*
gi 1718407979 414 GVTPGLVRLSLGVEDIEDILADLER 438
Cdd:PRK06767 357 GIYDNLIRLSVGLESWEDIVSDLEQ 381
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
5-443 |
1.41e-94 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 290.89 E-value: 1.41e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 5 TTPTPDAWGFSTAQVHAGVAVGQhaFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEG 84
Cdd:PRK07504 2 TTEMARKWRPATRLVHSGTLRSQ--FGETSEALFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 85 GVGALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGET 164
Cdd:PRK07504 80 AEDARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLV-DGLDLDNWEKAVRPNTKVFFLES 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 165 LGNPRGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagtfdyaqhaer 244
Cdd:PRK07504 159 PTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVL------------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 245 ypgfnepdesyhglvyardlgvgsplgANLAFILKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARW 324
Cdd:PRK07504 226 ---------------------------SDKAWIEEHLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADF 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 325 LEGRDDVEHVVYAGLESSPWHERAQRYLpKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQ 404
Cdd:PRK07504 279 LAGHPKVARVIYPGRADHPQADIIAKQM-TGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKN 357
|
410 420 430
....*....|....*....|....*....|....*....
gi 1718407979 405 LTDDEQRAAGVTPGLVRLSLGVEDIEDILADLERGFAAA 443
Cdd:PRK07504 358 LSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALKKV 396
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
9-442 |
4.74e-93 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 286.54 E-value: 4.74e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 9 PDAWGFSTAQVHAGVAvGQHAFGATALPIFQTTSYdfpsAQ--VAADRFALKdldplYTRIGNPTQGPVEEKIAALEGGV 86
Cdd:PRK07811 8 HANQGFATRAIHAGYE-PDPATGAVNPPIYASSTF----AQdgVGGLRGGYE-----YARTGNPTRTALEEQLAALEGGA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 87 GALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTfVTDPDDLESWRAAVRPNTKAFFGETLG 166
Cdd:PRK07811 78 YGRAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYT-PVDLSDLDAVRAAITPRTKLIWVETPT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 167 NPRGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagtfdyaqhaeryp 246
Cdd:PRK07811 157 NPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALV--------------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 247 gFNEPDesyhglvyardlgvgspLGANLAFILKArvqllrdYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLE 326
Cdd:PRK07811 222 -TNDEE-----------------LDEAFAFLQNG-------AGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 327 GRDDVEHVVYAGLESSPWHERAQRYLpKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHsqlt 406
Cdd:PRK07811 277 GHPEVSTVLYPGLPSHPGHEVAARQM-RGFGGMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEHPSAMTH---- 351
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1718407979 407 ddeQRAAG----VTPGLVRLSLGVEDIEDILADLERGFAA 442
Cdd:PRK07811 352 ---ASTAGsqleVPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
31-443 |
1.62e-91 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 283.12 E-value: 1.62e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 31 GATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGAGD 110
Cdd:PRK05939 8 GAVHKPIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 111 HVVASASLYGGTQNLFKhTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVPLI 190
Cdd:PRK05939 88 HLVSSQFLFGNTNSLFG-TLRGLGVEVTMV-DATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 191 VDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYAQHAERYPGFNEPDESYHGLVYARDLGvgspl 270
Cdd:PRK05939 166 VDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDTGLFDWSAYPNIFPAYRKGDPQQWGLTQIRKKG----- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 271 ganlafilkarvqlLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHERAQR 350
Cdd:PRK05939 241 --------------LRDMGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATE 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 351 YLpKGAGAFVSFEIAGGREAgAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAGVTPGLVRLSLGVEDIE 430
Cdd:PRK05939 307 LF-RHYGGLLSFELADGIDC-FDFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEA 384
|
410
....*....|...
gi 1718407979 431 DILADLERGFAAA 443
Cdd:PRK05939 385 DLIADFEQALDAT 397
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
6-441 |
2.90e-90 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 280.08 E-value: 2.90e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 6 TPTPDAWGFSTAQVHAGVAvgQHAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGG 85
Cdd:PRK07810 8 KALPDGVSQATIGVRGGLL--RSGFEETAEALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 86 VGALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETL 165
Cdd:PRK07810 86 EACFATASGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFV-DGEDLSQWEEALSVPTQAVFFETP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 166 GNPRGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdaGTFDYaqhaery 245
Cdd:PRK07810 165 SNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAIL--GDREY------- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 246 pgfnepdesyhglvyardlgVGSPLGanlafilkarvQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWL 325
Cdd:PRK07810 236 --------------------IDGPVQ-----------KLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 326 EGRDDVEHVVYAGLESSPWHERAQRYLpKGAGAFVSFEIAGGREAGA----AFVDGLTLHHHVANIGDVRSLVVHPASTT 401
Cdd:PRK07810 285 EGHPAVRWVRYPFLPSHPQYDLAKRQM-SGGGTVVTFELDAPEDAAKkrafEVLDKLRVIDISNNLGDAKSLITHPATTT 363
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1718407979 402 HSQLTDDEQRAAGVTPGLVRLSLGVEDIEDILADLERGFA 441
Cdd:PRK07810 364 HRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
36-438 |
1.43e-88 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 275.02 E-value: 1.43e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 36 PIFQTTSYDFPSAQVAADR-FALKdldplYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGAGDHVVA 114
Cdd:PRK08574 23 PIYLTALFRQEGEAYPSDRgFDLK-----YSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLFFSLLKAGDRVVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 115 SASLYGGTQNLFKhTLAKVGVETTFVTdPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVPLIVDNT 194
Cdd:PRK08574 98 PMEAYGTTLRLLK-SLEKFGVKVVLAY-PSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILVVDNT 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 195 LATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTfdyaqhaerypgfNEPDESYHglvYARDLgvgsplganl 274
Cdd:PRK08574 176 FATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSG-------------EFLEELWE---WRRRL---------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 275 afilkarvqllrdyGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHERAQRYLPK 354
Cdd:PRK08574 230 --------------GTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGK 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 355 GA-GAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAGVTPGLVRLSLGVEDIEDIL 433
Cdd:PRK08574 296 DLyGGVVSFRVKGGRDAVLKFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLI 375
|
....*
gi 1718407979 434 ADLER 438
Cdd:PRK08574 376 EDLDQ 380
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
16-441 |
5.27e-85 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 265.43 E-value: 5.27e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 16 TAQVHAGVAVGQHAfGATALPIFQTTSYDFPSAQVAADRfalkdldpLYTRIGNPTQGPVEEKIAALEGGVGALLLASGQ 95
Cdd:PRK07671 5 TKLIHGGIIGDPST-GAVSVPIYQVSTYKQEAVGKHQGY--------EYSRTGNPTRAALEELIAVLEGGHAGFAFGSGM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 96 AATTfAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDV 175
Cdd:PRK07671 76 AAIT-AVMMLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFV-DTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 176 RAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagtfdyaqhaerypgfnepdesy 255
Cdd:PRK07671 154 KKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVV------------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 256 hglvyardlgVGSP-LGANLAFILKARvqllrdyGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHV 334
Cdd:PRK07671 210 ----------VNSPeLAEDLHFVQNST-------GGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 335 VYAGLESSPWHERAQRYLpKGAGAFVSFEIaGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAG 414
Cdd:PRK07671 273 YYPGLPSHPNHELAKEQA-NGFGGMISFDV-GSEETANKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELG 350
|
410 420
....*....|....*....|....*..
gi 1718407979 415 VTPGLVRLSLGVEDIEDILADLERGFA 441
Cdd:PRK07671 351 ITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
10-444 |
1.68e-84 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 265.07 E-value: 1.68e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 10 DAWGFSTAQVHAGVAVgQHAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGAL 89
Cdd:PRK08249 5 NNAGVGTKAVWAGEKE-YLPYGATQVPVVLSVAYGYDDIDEWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAAT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 90 LLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPR 169
Cdd:PRK08249 84 AFSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLC-ETGDHEQIEAEIAKGCDLLYLETPTNPT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 170 GDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdaGTFDYAQHAERYPGFN 249
Cdd:PRK08249 163 LKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVC--GSKELMEQVYHYREIN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 250 epdesyhglvyardlgvgsplganlafilkarvqllrdyGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRD 329
Cdd:PRK08249 241 ---------------------------------------GATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHP 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 330 DVEHVVYAGLESSPWHERAQRYLpKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDE 409
Cdd:PRK08249 282 KVEAVYYPGLETHPNHEIAKAQM-RGFGGILSFVLKGGMDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEE 360
|
410 420 430
....*....|....*....|....*....|....*
gi 1718407979 410 QRAAGVTPGLVRLSLGVEDIEDILADLERGFAAAA 444
Cdd:PRK08249 361 RAALGIPEGLVRISVGIEDTEDLIADLEQAFAHLE 395
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
12-441 |
4.97e-81 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 255.85 E-value: 4.97e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 12 WGFSTAQVHAGVAVGQHAfGATALPIFQTTSYDfpsaQVAADRFALKDldplYTRIGNPTQGPVEEKIAALEGGVGALLL 91
Cdd:PRK08064 5 YSIDTLLLHNQYKHDKQT-GAVNVPIYHASTFH----QFDFDTFGKYD----YSRSGNPTREALEDIIAELEGGTKGFAF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 92 ASGQAATTFAILNVAgAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGD 171
Cdd:PRK08064 76 ASGMAAISTAFLLLS-KGDHVLISEDVYGGTYRMITEVLSRFGIEHTFV-DMTNLEEVAQNIKPNTKLFYVETPSNPLLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 172 VLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagtfdyaqhaerypgfnEP 251
Cdd:PRK08064 154 VTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAV------------------VK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 252 DESyhglvyardlgvgspLGANLAFILKArvqllrdYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDV 331
Cdd:PRK08064 216 DEE---------------LAQKLYFLQNS-------FGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 332 EHVVYAGLESSPWHErAQRYLPKGAGAFVSFEIAgGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQR 411
Cdd:PRK08064 274 QNVYYPGLQTHLGFD-IQQSQATSAGAVLSFTLQ-SEEAVRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEERD 351
|
410 420 430
....*....|....*....|....*....|
gi 1718407979 412 AAGVTPGLVRLSLGVEDIEDILADLERGFA 441
Cdd:PRK08064 352 ERGITDGLLRLSVGLENVDDLIADFEQALS 381
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
14-443 |
7.00e-80 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 251.93 E-value: 7.00e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 14 FSTAQVHAGvavgqhafgatalpIFQTTSYDfpsaqvaadrfalkdldplYTRIGNPTQGPVEEKIAALEGGVGALLLAS 93
Cdd:PRK08247 29 FSTAYRHEG--------------IGESTGFD-------------------YSRTGNPTRGVLEQAIADLEGGDQGFACSS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 94 GQAATTfAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVL 173
Cdd:PRK08247 76 GMAAIQ-LVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYV-NTASLKAIEQAITPNTKAIFIETPTNPLMQET 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 174 DVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagtfdyaqhaerypgfnepde 253
Cdd:PRK08247 154 DIAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVV---------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 254 syhglvyARdlgvGSPLGANLAFILKArvqllrdYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEH 333
Cdd:PRK08247 212 -------AK----GQELCERLAYYQNA-------AGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTD 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 334 VVYAglesspwheraqrylpkGAGAFVSFEIAgGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAA 413
Cdd:PRK08247 274 VLYP-----------------GRGGMLSFRLQ-DEEWVNPFLKSLKLITFAESLGGVESFITYPATQTHADIPEEIRIAN 335
|
410 420 430
....*....|....*....|....*....|
gi 1718407979 414 GVTPGLVRLSLGVEDIEDILADLERGFAAA 443
Cdd:PRK08247 336 GVCNRLLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
14-442 |
3.25e-79 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 250.59 E-value: 3.25e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 14 FSTAQVHAGVAVGQHAfGATALPIFQTTSYDfpsaQVAADRfaLKDLDplYTRIGNPTQGPVEEKIAALEGGVGALLLAS 93
Cdd:PRK06176 3 MQTKLIHGGISEDTTT-GAVSVPIYQTSTYR----QDAIGR--PKGYE--YSRSGNPTRFALEELIADLEGGVKGFAFAS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 94 GQAATtFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVL 173
Cdd:PRK06176 74 GLAGI-HAVFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTII-DTSDLSQIKKAIKPNTKALYLETPSNPLLKIT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 174 DVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDagtfdyaqhaerypgfNEPDe 253
Cdd:PRK06176 152 DLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTT----------------NNEA- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 254 syhglvyardlgvgspLGANLAFILKArvqllrdYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEH 333
Cdd:PRK06176 215 ----------------LAQEIAFFQNA-------IGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEK 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 334 VVYAGLESSPWHERAQRYLpKGAGAFVSFEIAGGREAgAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAA 413
Cdd:PRK06176 272 VYYPGLPTHPNHELAKKQM-RGFSGMLSFTLKNDSEA-VAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAA 349
|
410 420
....*....|....*....|....*....
gi 1718407979 414 GVTPGLVRLSLGVEDIEDILADLERGFAA 442
Cdd:PRK06176 350 GIRDGLVRLSVGIEHEQDLLEDLEQAFAK 378
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
30-443 |
1.86e-78 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 248.59 E-value: 1.86e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 30 FGATALPIFQTTSYDFPSAqvaaDRFALKDldplYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTfAILNVAGAG 109
Cdd:TIGR01329 15 YDASSMPIYQTATFKQPLA----IENGPYD----YTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALD-VITRLLNNG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 110 DHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVPL 189
Cdd:TIGR01329 86 DEIIAGDDLYGGTDRLLTQVVPRSGVVVVHV-DTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 190 IVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagtfdyaqhaerypgFNEPDesyhglvyardlgvgsp 269
Cdd:TIGR01329 165 VVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLA----------------VKGEE----------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 270 LGANLAFILKARvqllrdyGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHErAQ 349
Cdd:TIGR01329 212 IAKKVYFLQNST-------GSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFH-LH 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 350 RYLPKGAGAFVSFEiAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAGVTPGLVRLSLGVEDI 429
Cdd:TIGR01329 284 FSQAKGAGSVLSFE-TGSVALSKRLVEATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDV 362
|
410
....*....|....
gi 1718407979 430 EDILADLERGFAAA 443
Cdd:TIGR01329 363 DDLISDLDIAFVTA 376
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
29-438 |
1.76e-75 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 240.89 E-value: 1.76e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 29 AFGATALPIFQTTSYDFPSAQvaadRFAlkdldplYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGA 108
Cdd:PRK06460 15 ATGAITTPIYQTTAYHYPEGE----KYR-------YSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 109 GDHVVASASLYGGTQNLFKHTLAKVGVETTfVTDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVP 188
Cdd:PRK06460 84 GNSVLVHRDMFGRSYRFFTDYLKNWGVNVD-ASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 189 LIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIvdAGTFDYaqhaerypgfnepdesyhglvyardlgvgs 268
Cdd:PRK06460 163 LIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLA--AGYGKL------------------------------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 269 plganlafiLKARVQLLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHERA 348
Cdd:PRK06460 211 ---------LNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 349 QRYLpKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAGVTPGLVRLSLGVED 428
Cdd:PRK06460 282 RRVL-KGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIED 360
|
410
....*....|
gi 1718407979 429 IEDILADLER 438
Cdd:PRK06460 361 VNDLIEDLDR 370
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
13-442 |
1.23e-74 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 239.03 E-value: 1.23e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 13 GFSTAQVHAGvAVGQHAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLA 92
Cdd:PRK06434 8 GFNTRAVQSG-ELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 93 SGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRpNTKAFFGETLGNPRGDV 172
Cdd:PRK06434 87 SGMGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYI-DTDRLNSLDFDPS-NYDLIYAESITNPTLKV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 173 LDVRAVADAAHEAGVplIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVivdAGTFDyaqhaerypgfnepD 252
Cdd:PRK06434 165 PDIKNVSSFCHENDV--IVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGV---AGTNN--------------K 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 253 ESYHGLVYARdlgvgsplganlafilkarvqllRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVE 332
Cdd:PRK06434 226 SIFNNLVERR-----------------------KTLGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKIS 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 333 HVVYAGLESspwherAQRYLpKGAGAFVSFEIAGGREAgAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRA 412
Cdd:PRK06434 283 NVYYPDTEI------GKKVL-RGFGGMLSFELRSMEDV-HKFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERER 354
|
410 420 430
....*....|....*....|....*....|
gi 1718407979 413 AGVTPGLVRLSLGVEDIEDILADLERGFAA 442
Cdd:PRK06434 355 LGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
15-454 |
1.76e-70 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 228.72 E-value: 1.76e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 15 STAQVHAGVAvGQHAFGATALPIFQTTSYDFpsaqvaaDRFALK-DLDplYTRIGNPTQGPVEEKIAALEGGVGALLLAS 93
Cdd:PRK08776 14 ATAAVRAGID-RDTAYGAVTPPIVLSSNFSF-------DGFGNKrQYD--YTRSGNPTRDLLGEALAELEGGAGGVITAT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 94 GQAATTFAILNVAGAGDHVVASASLYGGTQNLFkHTLAKVGVETTFVTDPDDLESWRAAVRPNTKAFFGETLGNPRGDVL 173
Cdd:PRK08776 84 GMGAINLVLNALLQPGDTLVVPHDAYGGSWRLF-NALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRIT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 174 DVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAgtfDYAQHAErypgfnepde 253
Cdd:PRK08776 163 DLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVAR---DAELHQQ---------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 254 syhgLVY-ARDLGVGSplganlafilkarvqllrdygsaiSPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVE 332
Cdd:PRK08776 230 ----LVWwANALGLTG------------------------SPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVN 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 333 HVVYAGLESSPWHERAQRYlPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRA 412
Cdd:PRK08776 282 QVYYPGLASHPGHALAARQ-QKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARAA 360
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1718407979 413 AGVTPGLVRLSLGVEDIEDILADLERGFAAAARRGDDDAGER 454
Cdd:PRK08776 361 AGISDGLLRLSVGIESAEDLLIDLRAGLARAEAVLTAAARKK 402
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
31-443 |
8.18e-69 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 225.32 E-value: 8.18e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 31 GATALPIFQTTSYDFPSAQVAADRF----ALKDLDP------LYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTF 100
Cdd:PRK07049 34 GAVKPPVFLTSTFVFRSAEDGRDFFdyvsGRKEPPAgegaglVYSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIAT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 101 AILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVTDPDDLESWRAAV-----RPNTKAFFGETLGNPRGDVLDV 175
Cdd:PRK07049 114 TLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVGFADGLSEAAIGAAAeaaaaKGRVSLILIETPANPTNSLVDV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 176 ---RAVADA--AHEAGVPLIV-DNTLATPYLLRPIEHGADVVTHSATKYLGGHAaaiagvivdagtfdyaqhaerypgfn 249
Cdd:PRK07049 194 aavRRVADAieARQGHRPIIAcDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHS-------------------------- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 250 epdesyhglvyarDLGVGSPLGANlAFIlkARVQLLRD-YGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGR 328
Cdd:PRK07049 248 -------------DLVAGAVLGRK-ALI--RQVRALRSaIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDH 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 329 DDVEHVVYAG-LESSPWHERAQRYLPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTD 407
Cdd:PRK07049 312 PKVEKLHYLPfLDPDSAYGAVYKRQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPA 391
|
410 420 430
....*....|....*....|....*....|....*.
gi 1718407979 408 DEQRAAGVTPGLVRLSLGVEDIEDILADLERGFAAA 443
Cdd:PRK07049 392 DVRERIGVLESTIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
28-445 |
6.94e-65 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 213.79 E-value: 6.94e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 28 HAFGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAG 107
Cdd:PRK05968 21 NAFDAVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISSTVLSFVE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 108 AGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVrPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGV 187
Cdd:PRK05968 101 PGDRIVAVRHVYPDAFRLFETILKRMGVEVDYV-DGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAALAALAKRHGV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 188 PLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAGTFDYAQHAERYPgfnepdesYhglvyardlgvg 267
Cdd:PRK05968 179 VTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYP--------Y------------ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 268 spLGANLafilkarvqllrdygsaiSPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPwher 347
Cdd:PRK05968 239 --LGAKL------------------SPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHP---- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 348 aqRYLPKGAGAFVSFEIAGGREAgAAFVDGLTLHHHVANIGDVRSLVVhPASTTHSQLTDDEQRAA-GVTPGLVRLSLGV 426
Cdd:PRK05968 295 --PAGLSGTSGLFSFIFREGIDV-RAFADALKLFRLGVSWGGHESLVV-PAEVVLQQKAQPNSAARfGVSPRSVRLHVGL 370
|
410
....*....|....*....
gi 1718407979 427 EDIEDILADLERGFAAAAR 445
Cdd:PRK05968 371 EGTEALWADLEQALAAASR 389
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
30-440 |
1.29e-64 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 215.28 E-value: 1.29e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 30 FGATALPIFQTTSYDFPSAqvaadrfalKDLDPL-YTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTfAILNVAGA 108
Cdd:PLN02509 101 FDAMSTPLYQTATFKQPSA---------IENGPYdYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKN 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 109 GDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVP 188
Cdd:PLN02509 171 GEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRV-NTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGAL 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 189 LIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVivdagtfdyaqhaerypgfnepdesyhglvyardLGV-G 267
Cdd:PLN02509 250 VLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGV----------------------------------LAVkG 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 268 SPLGANLAFILKARvqllrdyGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHEr 347
Cdd:PLN02509 296 EKLAKEVYFLQNSE-------GSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHH- 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 348 AQRYLPKGAGAFVSFeIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAGVTPGLVRLSLGVE 427
Cdd:PLN02509 368 LHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIE 446
|
410
....*....|...
gi 1718407979 428 DIEDILADLERGF 440
Cdd:PLN02509 447 DVDDLISDLDIAF 459
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
32-444 |
1.35e-64 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 212.83 E-value: 1.35e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 32 ATALPIFQTTSYDFPsaqvaadrfALKDLDPL-YTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGAGD 110
Cdd:PRK08861 23 AVVPPIYLSTNYGFP---------AFGEVPKYdYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLGPDD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 111 HVVASASLYGGTQNLFkHTLAKVGVETTFVTDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVPLI 190
Cdd:PRK08861 94 LIVAPHDCYGGTYRLF-NTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 191 VDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDagtfDYAQHAERYPGFnepdesyhglvyardlgvGSPL 270
Cdd:PRK08861 173 VDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLIT----KTKEHAEELAWW------------------GNCI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 271 GANLAfilkarvqllrdygsaisPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHERAQR 350
Cdd:PRK08861 231 GATGT------------------PFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKK 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 351 YlPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAGVTPGLVRLSLGVEDIE 430
Cdd:PRK08861 293 Q-QSGFGSMLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQ 371
|
410
....*....|....
gi 1718407979 431 DILADLERGFAAAA 444
Cdd:PRK08861 372 DLIADLDQAFAKAA 385
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
30-446 |
1.93e-63 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 209.75 E-value: 1.93e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 30 FGATALPIFQTTSYDFP--SAQVAADrfalkdldplYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAG 107
Cdd:PRK08045 20 YGCVVPPIHLSSTYNFTgfNEPRAHD----------YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 108 AGDHVVASASLYGGTQNLFKhTLAKVGVETTFVTDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGV 187
Cdd:PRK08045 90 PGDLLVAPHDCYGGSYRLFD-SLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 188 PLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDagtfdyaqhaerypgfNEPDESYHGLVYARDLGVG 267
Cdd:PRK08045 169 VSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIA----------------KDPDVVTELAWWANNIGVT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 268 splganlafilkarvqllrdyGSAispFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHER 347
Cdd:PRK08045 233 ---------------------GGA---FDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEI 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 348 AQRYlPKGAGAFVSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAAGVTPGLVRLSLGVE 427
Cdd:PRK08045 289 AARQ-QKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIE 367
|
410
....*....|....*....
gi 1718407979 428 DIEDILADLERGFAAAARR 446
Cdd:PRK08045 368 DGEDLIADLENGFRAANKG 386
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
1-444 |
5.88e-61 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 203.50 E-value: 5.88e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 1 MTDQTTPTPDAwGFSTAQVHAGVAVGQHaFGATALPIFQTTSYDFPSAQVAADRfalkDLDPLYTRIGNPTQGPVEEKIA 80
Cdd:PRK05967 1 MAKKQLKTEKA-GINTRLAHDGNDPGDY-HGFVNPPVVHASTVLFPDAETMATR----GQKYTYGTRGTPTTDALCKAID 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 81 ALEGGVGALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAF 160
Cdd:PRK05967 75 ALEGSAGTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYY-DPEIGAGIAKLMRPNTKVV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 161 FGETLGNPRGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIvdagtfdyAQ 240
Cdd:PRK05967 154 HTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTV--------SA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 241 HAERYPGFNEpdesyhglvyardlgvgsplganlafilkARVQLlrdyGSAISPFNAFLVNLGLETLSLRMERQVANAAA 320
Cdd:PRK05967 226 NEKCWPQLLE-----------------------------AHGTL----GLCAGPDDTYQILRGLRTMGIRLEHHRKSALE 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 321 VARWLEGRDDVEHVVYAGLESSPWHERAQRYLpKGAGAFVSFEIAGGREAG----AAFVDGLTLHHHVANIGDVRSLVVH 396
Cdd:PRK05967 273 IARWLEGRPDVARVLHPALPSFPGHEIWKRDF-SGASGIFSFVLAAGPEKGkakaHAFLDALEIFGLGYSWGGYESLALH 351
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1718407979 397 PAstthsqlTDDEQRAAGVTPG-LVRLSLGVEDIEDILADLERGFAAAA 444
Cdd:PRK05967 352 VK-------LGDRTVAKAPYAGpVIRLQIGLEDVPDLKADLERGFAAAS 393
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
11-443 |
5.67e-60 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 200.22 E-value: 5.67e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 11 AWGFSTAQVHAGVAVGQhAFGATALPIFQTTSYDFPSAQVAADrfalkdldPLYTRIGNPTQGPVEEKIAALEGGvGALL 90
Cdd:PRK07582 1 AYGDGTRSVHAGGPEAV-PGEPVLPGPVFAAPYHLSPGEPTGP--------DTYGRASNPTWRALEAALGELEGA-EALV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 91 LASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVTDPDDLESWRAAVRpntkAFFGETLGNPRG 170
Cdd:PRK07582 71 FPSGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGMAEAALAGAD----LVLAETPSNPGL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 171 DVLDVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIvdagtfdyaqhAERYPGfne 250
Cdd:PRK07582 147 DVCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYV-----------AGRDPE--- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 251 pdesyhglvyardlgvgsplganlafiLKARVQLLRDYGSAI-SPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRD 329
Cdd:PRK07582 213 ---------------------------LMAAVERWRLLAGAIpGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHP 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 330 DVEHVVYAGLESSPWHERAQRYLpKGAGAFVSFEIAgGREAGAAFVDGLTLHHHVANIGDVRSLVvhpastthsqltddE 409
Cdd:PRK07582 266 AVRGVRYPGLPGDPAHEVAARQM-RRFGGLVSFELA-DAAAAERFVAASRLVVAATSFGGVHTSA--------------D 329
|
410 420 430
....*....|....*....|....*....|....*..
gi 1718407979 410 QRAA---GVTPGLVRLSLGVEDIEDILADLERGFAAA 443
Cdd:PRK07582 330 RRARwgdAVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
63-442 |
1.43e-55 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 189.98 E-value: 1.43e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 63 LYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLA-KVGVETTFVt 141
Cdd:PLN02242 69 IYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPrKCNITTTFV- 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 142 DPDDLESWRAAVRPN-TKAFFGETLGNPRGDVLDVRAVADAAHEAGVPLIVDNTLAtPYLLRPIEHGADVVTHSATKYLG 220
Cdd:PLN02242 148 DITDLEAVKKAVVPGkTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFIS 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 221 GHAAAIAGVIVDagtfdyaqhaerypgfnePDESYHGLvyaRDLGVGSplganlafilkarVQLLrdyGSAISPFNAFLV 300
Cdd:PLN02242 227 GGADIIAGAVCG------------------PAELVNSM---MDLHHGA-------------LMLL---GPTMNPKVAFEL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 301 NLGLETLSLRMERQVANAAAVARWLEGRDdvEHVVYAGLESSPWHERAQRYLPK--GAGAFVSFEIaGGREAGAAFVDGL 378
Cdd:PLN02242 270 SERLPHLSLRMKEHCRRAMEYAKRMKELG--LKVIYPGLEDHPQHALLKSMANKgyGFGGLLCLDM-DTEERANRLMRYL 346
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1718407979 379 TLHHH----VANIGDVRSLVVHPASTTHSQLTDDEQRAAGVTPGLVRLSLG-VEDIEDILADLERGFAA 442
Cdd:PLN02242 347 QNSTQfgfmAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVGyTGTLEQRWSQFEKALSA 415
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
16-437 |
2.63e-55 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 188.11 E-value: 2.63e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 16 TAQVHAGVAVGQhAFGATALPIFQTTSYDFPS--AQVAADrfalkdldplYTRIGNPTQGPVEEKIAALEGGVGALLLAS 93
Cdd:PRK07269 9 TILAQAGIKSDE-ATGALVTPLHFSTTYQHPEfgQSTGFD----------YTRTKNPTRAKLEETLAAIESADYALATSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 94 GQAATTFAiLNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVTDPDDLeswRAAVRPNTKAFFGETLGNPRGDVL 173
Cdd:PRK07269 78 GMSAIVLA-FSVFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYANTEEEL---IAAIEEDTDIVYIETPTNPLMVEF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 174 DVRAVADAAHEAGVPLIVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagTFDyaqhaerypgfnepDE 253
Cdd:PRK07269 154 DIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVV---TND--------------LE 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 254 SYHGLVYArdlgvgsplganlafilkarvqlLRDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEH 333
Cdd:PRK07269 217 LYEKLFYN-----------------------LNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKE 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 334 VVYAGLesspwheraqrylpkgaGAFVSFEIAgGREAGAAFVDGLTLHHHVANIGDVRSLVVHPASTTHSQLTDDEQRAA 413
Cdd:PRK07269 274 VLYTGK-----------------GGMISFKVA-DETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSY 335
|
410 420
....*....|....*....|....
gi 1718407979 414 GVTPGLVRLSLGVEDIEDILADLE 437
Cdd:PRK07269 336 GLTDDLLRLSIGIEDARDLIADLK 359
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
36-441 |
3.50e-53 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 183.01 E-value: 3.50e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 36 PIFQTTSYDFPSaqVAADRFALKDL---DPLYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGAGDHV 112
Cdd:PRK09028 26 PVFRASTVVFDT--VAEMRHAAKNRangEMFYGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISNALLSFLKAGDHL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 113 VASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVPLIVD 192
Cdd:PRK09028 104 LMVDSCYEPTRDLCDKILKGFGIETTYY-DPMIGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 193 NTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVivdagtfdyAQHAERY-PGFNEpdESYhglvyardlgvgsplg 271
Cdd:PRK09028 183 NTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGT---------ATANEKHwDQLRE--HSY---------------- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 272 anlafilkarvqLLrdyGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHERAQRY 351
Cdd:PRK09028 236 ------------LM---GQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRD 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 352 LPKGAGAFvSFEI-AGGREAGAAFVDGLTLHHHVANIGDVRSLVVhpASTTHSQLTDDEQRAAGVTpgLVRLSLGVEDIE 430
Cdd:PRK09028 301 FSGSNGLF-SFVLkQGDPKAVTALVEGMQHFKMGFSWGGFESLIL--GVFGINKLRTATNWDFSKP--LIRLHIGLEDVD 375
|
410
....*....|.
gi 1718407979 431 DILADLERGFA 441
Cdd:PRK09028 376 DLIADLEAGFE 386
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
30-443 |
1.33e-52 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 181.23 E-value: 1.33e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 30 FGATALPIFQTTSYDFPSAqvAADRFALKDLdpLYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGAG 109
Cdd:TIGR01324 14 QGSVNPPLQRASTVLFDSH--AAQRRAKGEL--TYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVTNSILAFVKAG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 110 DHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVPL 189
Cdd:TIGR01324 90 DHVLMVDSAYEPTRYFCDIVLKRMGVDITYY-DPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAKAARNPGIVI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 190 IVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVDAgtfdyAQHAERYpgfnePDESYhglvyardlgvgsp 269
Cdd:TIGR01324 169 MIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVAN-----ARTWDQL-----REHSY-------------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 270 lganlafilkarvqllrDYGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHERAQ 349
Cdd:TIGR01324 225 -----------------LMGQMVDADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWK 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 350 RYLPKGAGAFvSFEIAG-GREAGAAFVDGLTLHHHVANIGDVRSLVVhpasTTHSQLTDDEQRAAGVTPGLVRLSLGVED 428
Cdd:TIGR01324 288 RDFSGSSGLF-SFVLQRlTQKQVHAFLDHLQLFGLGYSWGGYESLAL----CNQPELGHRPNIKRNLEGPLIRVHIGLEN 362
|
410
....*....|....*
gi 1718407979 429 IEDILADLERGFAAA 443
Cdd:TIGR01324 363 VDDLKADLKAGFEAI 377
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
30-445 |
8.63e-39 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 144.48 E-value: 8.63e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 30 FGATALPIFQTTSYDFPSAQVAADRFALKDLDPLYTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGAG 109
Cdd:PRK07050 25 FRSFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLVYFGLVKAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 110 DHVVASASLYGGTQNLFKHTLAKVGVETTFVtDPDDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVPL 189
Cdd:PRK07050 105 DDVLIPDNAYGPNRDHGEWLARDFGITVRFY-DPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 190 IVDNTLATPYLLRPIEHGADVVTHSATKYLGGHAAAIAGVIVdagTFDYAQHAErypgfnepdesyhglvyardlgvgsp 269
Cdd:PRK07050 184 AIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATI---TADAELHAK-------------------------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 270 lganlafILKARVQLlrdyGSAISPFNAFLVNLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHERAQ 349
Cdd:PRK07050 235 -------LKLARMRL----GIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWM 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 350 RYLPKGAGAF-VSFEIAGGREAGAAFVDGLTLHHHVANIGDVRSLVV--HPASTTHSQLTDDeqraagvtPGLVRLSLGV 426
Cdd:PRK07050 304 RDFTGAGGLFsVVFDERYSPAQVDAFVEALELFAIGWSWGGACSLAMpyDVASMRTAKWPHR--------GTLVRLYIGL 375
|
410
....*....|....*....
gi 1718407979 427 EDIEDILADLERGFAAAAR 445
Cdd:PRK07050 376 EDEADLIADLEQALEAALA 394
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
64-441 |
1.17e-38 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 144.08 E-value: 1.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 64 YTRIGNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNLFKHTLAKVGVETTFVtDP 143
Cdd:PRK08114 56 YGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWF-DP 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 144 DDLESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGvPLIV---DNTLATPYLLRPIEHGADVVTHSATKYLG 220
Cdd:PRK08114 135 LIGADIAKLIQPNTKVVFLESPGSITMEVHDVPAIVAAVRSVN-PDAVimiDNTWAAGVLFKALDFGIDISIQAGTKYLV 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 221 GHAAAIAGVIVdAGTFDYAQHAErypgfnepdESYhglvyardlgvgsplganlafilkarvqLLrdyGSAISPFNAFLV 300
Cdd:PRK08114 214 GHSDAMIGTAV-ANARCWEQLRE---------NSY----------------------------LM---GQMVDADTAYMT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 301 NLGLETLSLRMERQVANAAAVARWLEGRDDVEHVVYAGLESSPWHERAQRYLPKGAGAFvSFEIAG--GREAGAAFVDGL 378
Cdd:PRK08114 253 SRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLF-SFVLKKklTDEQLANYLDNF 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 379 TLHHHVANIGDVRSLVVHpastthsqlTDDEQRAA-------GVTPGLVRLSLGVEDIEDILADLERGFA 441
Cdd:PRK08114 332 SLFSMAYSWGGFESLILA---------NQPEEIAAirpagevDFTGTLIRLHIGLEDVDDLIADLAAGFA 392
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
76-231 |
5.19e-13 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 67.02 E-value: 5.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 76 EEKIAAL--EGGVGALLLASGQAATTFAILNVAGAGDHVVASASLYGGTQNlfkHTLAKVGVETTFVTDPDD-------L 146
Cdd:cd01494 6 EEKLARLlqPGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYW---VAAELAGAKPVPVPVDDAgyggldvA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 147 ESWRAAVRPNTKAFFGETLGNPRGDVLDVRAVADAAHEAGVPLIVDNTLATPY----LLRPIEHGADVVTHSATKYLGGh 222
Cdd:cd01494 83 ILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLHKNLGG- 161
|
....*....
gi 1718407979 223 aaAIAGVIV 231
Cdd:cd01494 162 --EGGGVVI 168
|
|
| KBL_like |
cd06454 |
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ... |
75-228 |
4.81e-06 |
|
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.
Pssm-ID: 99747 [Multi-domain] Cd Length: 349 Bit Score: 48.33 E-value: 4.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 75 VEEKIAALEGGVGALLLASGQAATTFAILNVAGAGDHVVAS----ASLYGGTQN------LFKHtlakvgvettfvTDPD 144
Cdd:cd06454 51 LEEELAEFHGKEAALVFSSGYAANDGVLSTLAGKGDLIISDslnhASIIDGIRLsgakkrIFKH------------NDME 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 145 DLES-WRAAVRPNTKAFF-GETLGNPRGDVLDVRAVADAAHEAGVPLIVDNTLATPYLLrpiEHGA------------DV 210
Cdd:cd06454 119 DLEKlLREARRPYGKKLIvTEGVYSMDGDIAPLPELVDLAKKYGAILFVDEAHSVGVYG---PHGRgveefggltddvDI 195
|
170
....*....|....*...
gi 1718407979 211 VTHSATKYLGGHAAAIAG 228
Cdd:cd06454 196 IMGTLGKAFGAVGGYIAG 213
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
71-217 |
7.25e-05 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 44.58 E-value: 7.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 71 TQGP----VEEKIAALEGGVGALLLASGQAATTFAILNV-AGAGDHVVASASLYGGTQNLFKHTLAK---VGVE-TTFVT 141
Cdd:pfam01041 21 TTGPyvreFERAFAAYLGVKHAIAVSSGTAALHLALRALgVGPGDEVITPSFTFVATANAALRLGAKpvfVDIDpDTYNI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 142 DPDDLEswrAAVRPNTKAFFGETLGnprGDVLDVRAVADAAHEAGVPLIVD--NTLATPYLLRPIEHGADVVTHS--ATK 217
Cdd:pfam01041 101 DPEAIE---AAITPRTKAIIPVHLY---GQPADMDAIRAIAARHGLPVIEDaaHALGATYQGKKVGTLGDAATFSfhPTK 174
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
100-221 |
2.99e-04 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 42.84 E-value: 2.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 100 FAILNVAGAGDHVVAS----ASlyggtqNLFK-HTLA-KVGVETTFV-TDPD---DLESWRAAVRPNTKAFFGETLGNPR 169
Cdd:cd06453 79 YGLGRANKPGDEIVTSvmehHS------NIVPwQQLAeRTGAKLKVVpVDDDgqlDLEALEKLLTERTKLVAVTHVSNVL 152
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1718407979 170 GDVLDVRAVADAAHEAGVPLIVDNTLATPYLlrPI---EHGADVVTHSATKYLGG 221
Cdd:cd06453 153 GTINPVKEIGEIAHEAGVPVLVDGAQSAGHM--PVdvqDLGCDFLAFSGHKMLGP 205
|
|
| SelA |
COG1921 |
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis]; |
133-231 |
7.38e-04 |
|
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441524 Cd Length: 399 Bit Score: 41.65 E-value: 7.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 133 VGveTTFVTDPDDLEswrAAVRPNTKAFF----------GETlgnprgDVLDVRAVADAAHEAGVPLIVDntLA------ 196
Cdd:COG1921 136 VG--TTNRTHLRDYE---AAITENTAALLkvhtsnyrivGFT------EEVSLAELAELAHEHGLPVIVD--LGsgslvd 202
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1718407979 197 -TPYLLRP-------IEHGADVVTHSATKYLGGHAaaiAGVIV 231
Cdd:COG1921 203 lSKYGLPHeptvqeyLAAGADLVTFSGDKLLGGPQ---AGIIV 242
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
43-192 |
1.64e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 40.37 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 43 YDFPSAQVAADRFALKDLDPLYTRIGnPTQGPVE--EKIAALEGG--------VGALLLASG-QAATTFAILNVAGAGDH 111
Cdd:pfam00155 11 YLGDTLPAVAKAEKDALAGGTRNLYG-PTDGHPElrEALAKFLGRspvlkldrEAAVVFGSGaGANIEALIFLLANPGDA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 112 VVASASLYGGTQNLFKhtLAKVGVETTFVTDPD----DLESWRAAVRPNTKAFFGETLGNPRGDVL---DVRAVADAAHE 184
Cdd:pfam00155 90 ILVPAPTYASYIRIAR--LAGGEVVRYPLYDSNdfhlDFDALEAALKEKPKVVLHTSPHNPTGTVAtleELEKLLDLAKE 167
|
....*...
gi 1718407979 185 AGVPLIVD 192
Cdd:pfam00155 168 HNILLLVD 175
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
98-192 |
2.45e-03 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 40.12 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 98 TTFAILNVA------GAGDHVVASASLYGGTQNLFKHTLAKVGVETTFV-TDPD---DLESWRAAVRPNTK--AFFGetL 165
Cdd:COG0520 86 TTEAINLVAyglgrlKPGDEILITEMEHHSNIVPWQELAERTGAEVRVIpLDEDgelDLEALEALLTPRTKlvAVTH--V 163
|
90 100
....*....|....*....|....*..
gi 1718407979 166 GNPRGDVLDVRAVADAAHEAGVPLIVD 192
Cdd:COG0520 164 SNVTGTVNPVKEIAALAHAHGALVLVD 190
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
113-227 |
2.75e-03 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 40.01 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 113 VASASLY-GGT----------------------QNLFKHTLAKV-------GVETTFVTDPD---DLESWRAAVRPNTka 159
Cdd:COG0403 129 VANASLYdGATaaaeamlmarrvtkrsnkvlvsEDVHPQTRAVLktyaeplGIEVVEVPDEDgvtDLEALKALLDDDV-- 206
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1718407979 160 fFGETLGNP--RGDVLDVRAVADAAHEAGVPLIVD-NTLATPYLLRPIEHGADVVTHSA------TKYLGGHAAAIA 227
Cdd:COG0403 207 -AGVLVQYPnfFGVIEDLRAIAEAAHAAGALVIVAaDPLSLGLLKPPGELGADIVVGEGqrlgvpLGFGGPHAGFFA 282
|
|
| PRK07550 |
PRK07550 |
aminotransferase; |
101-194 |
5.63e-03 |
|
aminotransferase;
Pssm-ID: 181026 [Multi-domain] Cd Length: 386 Bit Score: 38.79 E-value: 5.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 101 AILNVAGAGDHVVASASLYggtqnlFKH--TLAKVGVETTFV-TDPD-----DLESWRAAVRPNTKAFFGETLGNPRGDV 172
Cdd:PRK07550 106 AMVTLAGAGDEVILPLPWY------FNHkmWLDMLGIRPVYLpCDEGpgllpDPAAAEALITPRTRAIALVTPNNPTGVV 179
|
90 100
....*....|....*....|....*
gi 1718407979 173 LD---VRAVADAAHEAGVPLIVDNT 194
Cdd:PRK07550 180 YPpelLHELYDLARRHGIALILDET 204
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
164-221 |
6.62e-03 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 38.38 E-value: 6.62e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1718407979 164 TLGNPRGDVLDVRAVADAAHEAGVPLIVDNT------LATPYLLRPIEHGADVVTHSATKYLGG 221
Cdd:cd00615 161 TNPTYYGICYNLRKIVEEAHHRGLPVLVDEAhgahfrFHPILPSSAAMAGADIVVQSTHKTLPA 224
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
68-245 |
9.83e-03 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 37.97 E-value: 9.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 68 GNPTQGPVEEKIAALEGGVGALLLASGQAATTFAILNVAGAGDHVVASAslyggTQNLFKHTLAKVGV-----ETTFVTD 142
Cdd:pfam01212 30 GDPTVNRLEDRVAELFGKEAALFVPSGTAANQLALMAHCQRGDEVICGE-----PAHIHFDETGGHAElggvqPRPLDGD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718407979 143 PD---DLESWRAAVRPNTKAFFGE--------TLGNPRGDVL---DVRAVADAAHEAGVPLIVD------NTLATPYLLR 202
Cdd:pfam01212 105 EAgnmDLEDLEAAIREVGADIFPPtglislenTHNSAGGQVVsleNLREIAALAREHGIPVHLDgarfanAAVALGVIVK 184
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1718407979 203 PIEHGADVVTHSATKYLGghaAAIAGVIvdAGTFDYAQHAERY 245
Cdd:pfam01212 185 EITSYADSVTMCLSKGLG---APVGSVL--AGSDDFIAKAIRQ 222
|
|
| |
