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Conserved domains on  [gi|1724454746|ref|WP_147197141|]
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MULTISPECIES: anti-sigma regulatory factor [Rummeliibacillus]

Protein Classification

anti-sigma regulatory factor( domain architecture ID 13014755)

anti-sigma regulatory factor similar to RsbT, an ATPase with serine/threonine kinase activity that phosphorylates its antagonist RsbS and stimulates the phosphatase RsbU in a signaling cascade that results in active sigma-B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 13-129 4.90e-32

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


:

Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 109.77  E-value: 4.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  13 DIVTARQLGRKEAKSIGFDIIDQALIATAISELARNIHLYAESGKIEVKKLIQEKSVGIYVIASDNGPGIPQIDELLQKD 92
Cdd:cd16934     1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1724454746  93 LATTKGIGFGLPGVKRIMDEFQLDSQLTIGTTVKIKK 129
Cdd:cd16934    81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVVVARK 117
 
Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 13-129 4.90e-32

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 109.77  E-value: 4.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  13 DIVTARQLGRKEAKSIGFDIIDQALIATAISELARNIHLYAESGKIEVKKLIQEKSVGIYVIASDNGPGIPQIDELLQKD 92
Cdd:cd16934     1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1724454746  93 LATTKGIGFGLPGVKRIMDEFQLDSQLTIGTTVKIKK 129
Cdd:cd16934    81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVVVARK 117
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
10-131 1.46e-22

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 85.74  E-value: 1.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  10 TEWDIVTARQLGRKEAKSIGFDIIDQALIATAISELARNIHLYA----ESGKIEVKklIQEKSVGIYVIASDNGPGIPQI 85
Cdd:COG2172     7 DLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAyggdPDGPVEVE--LELDPDGLEIEVRDEGPGFDPE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1724454746  86 DelLQKDLATTKGIGFGLPGVKRIMDEFQLDSQLTiGTTVKIKKWL 131
Cdd:COG2172    85 D--LPDPYSTLAEGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKRL 127
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 33-132 1.50e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 49.18  E-value: 1.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746   33 IDQALIATAISELARN-IHLYAESGKIEVKklIQEKSVGIYVIASDNGPGIP--QIDELLQ------KDLATTKGIGFGL 103
Cdd:smart00387   1 GDPDRLRQVLSNLLDNaIKYTPEGGRITVT--LERDGDHVEITVEDNGPGIPpeDLEKIFEpffrtdKRSRKIGGTGLGL 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1724454746  104 PGVKRIMDEFQ----LDSQLTIGTTVKIKKWLS 132
Cdd:smart00387  79 SIVKKLVELHGgeisVESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 34-128 9.50e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 46.98  E-value: 9.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  34 DQALIATAISELARN-IHLYAESGKIEVKkLIQEKSVGIYViaSDNGPGIP--QIDELLQK----DLATTKGIGFGLPGV 106
Cdd:pfam02518   2 DELRLRQVLSNLLDNaLKHAAKAGEITVT-LSEGGELTLTV--EDNGIGIPpeDLPRIFEPfstaDKRGGGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*.
gi 1724454746 107 KRIMD----EFQLDSQLTIGTTVKIK 128
Cdd:pfam02518  79 RKLVEllggTITVESEPGGGTTVTLT 104
envZ PRK09467
osmolarity sensor protein; Provisional
 38-123 7.79e-06

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 43.75  E-value: 7.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  38 IATAISELARNIHLYAeSGKIEVKKLIQEKSVGIYViaSDNGPGIP--QIDELLQK----DLA-TTKGIGFGLPGVKRIM 110
Cdd:PRK09467  332 IKRALANLVVNAARYG-NGWIKVSSGTEGKRAWFQV--EDDGPGIPpeQLKHLFQPftrgDSArGSSGTGLGLAIVKRIV 408

                          90
                  ....*....|...
gi 1724454746 111 DefQLDSQLTIGT 123
Cdd:PRK09467  409 D--QHNGKVELGN 419
 
Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 13-129 4.90e-32

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 109.77  E-value: 4.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  13 DIVTARQLGRKEAKSIGFDIIDQALIATAISELARNIHLYAESGKIEVKKLIQEKSVGIYVIASDNGPGIPQIDELLQKD 92
Cdd:cd16934     1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1724454746  93 LATTKGIGFGLPGVKRIMDEFQLDSQLTIGTTVKIKK 129
Cdd:cd16934    81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVVVARK 117
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
10-131 1.46e-22

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 85.74  E-value: 1.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  10 TEWDIVTARQLGRKEAKSIGFDIIDQALIATAISELARNIHLYA----ESGKIEVKklIQEKSVGIYVIASDNGPGIPQI 85
Cdd:COG2172     7 DLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAyggdPDGPVEVE--LELDPDGLEIEVRDEGPGFDPE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1724454746  86 DelLQKDLATTKGIGFGLPGVKRIMDEFQLDSQLTiGTTVKIKKWL 131
Cdd:COG2172    85 D--LPDPYSTLAEGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKRL 127
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 33-132 1.50e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 49.18  E-value: 1.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746   33 IDQALIATAISELARN-IHLYAESGKIEVKklIQEKSVGIYVIASDNGPGIP--QIDELLQ------KDLATTKGIGFGL 103
Cdd:smart00387   1 GDPDRLRQVLSNLLDNaIKYTPEGGRITVT--LERDGDHVEITVEDNGPGIPpeDLEKIFEpffrtdKRSRKIGGTGLGL 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1724454746  104 PGVKRIMDEFQ----LDSQLTIGTTVKIKKWLS 132
Cdd:smart00387  79 SIVKKLVELHGgeisVESEPGGGTTFTITLPLE 111
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 38-128 2.66e-08

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 48.37  E-value: 2.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  38 IATAISELARNIHLYA-ESGKIEVKklIQEKSVGIYVIASDNGPGIP--QIDELLQ-----KDLATTKGIGFGLPGVKRI 109
Cdd:cd00075     1 LEQVLSNLLDNALKYSpPGGTIEIS--LRQEGDGVVLEVEDNGPGIPeeDLERIFErfyrgDKSREGGGTGLGLAIVRRI 78

                          90       100
                  ....*....|....*....|...
gi 1724454746 110 MD----EFQLDSQLTIGTTVKIK 128
Cdd:cd00075    79 VEahggRITVESEPGGGTTFTVT 101
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 34-128 9.50e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 46.98  E-value: 9.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  34 DQALIATAISELARN-IHLYAESGKIEVKkLIQEKSVGIYViaSDNGPGIP--QIDELLQK----DLATTKGIGFGLPGV 106
Cdd:pfam02518   2 DELRLRQVLSNLLDNaLKHAAKAGEITVT-LSEGGELTLTV--EDNGIGIPpeDLPRIFEPfstaDKRGGGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*.
gi 1724454746 107 KRIMD----EFQLDSQLTIGTTVKIK 128
Cdd:pfam02518  79 RKLVEllggTITVESEPGGGTTVTLT 104
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 32-128 7.15e-07

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 46.88  E-value: 7.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  32 IIDQALIATAISELARN-IHLYAESGKIEVKKLIQEKSVGIYVIasDNGPGIPqiDELLQKDL---ATTK--GIGFGLPG 105
Cdd:COG5000   312 LADRDQLEQVLINLLKNaIEAIEEGGEIEVSTRREDGRVRIEVS--DNGPGIP--EEVLERIFepfFTTKpkGTGLGLAI 387

                          90       100
                  ....*....|....*....|....*..
gi 1724454746 106 VKRIMDE----FQLDSQLTIGTTVKIK 128
Cdd:COG5000   388 VKKIVEEhggtIELESRPGGGTTFTIR 414
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 38-131 3.49e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 42.82  E-value: 3.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  38 IATAISELARNIHLYAeSGKIEVKKLIQEKSVGIYVIasDNGPGIP--QIDELLQK----DLA-TTKGIGFGLPGVKRIM 110
Cdd:cd16950     1 LKRVLSNLVDNALRYG-GGWVEVSSDGEGNRTRIQVL--DNGPGIApeEVDELFQPfyrgDNArGTSGTGLGLAIVQRIS 77

                          90       100
                  ....*....|....*....|....*
gi 1724454746 111 DefQLDSQLTIGTT----VKIKKWL 131
Cdd:cd16950    78 D--AHGGSLTLANRagggLCARIEL 100
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 34-128 3.68e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 43.16  E-value: 3.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  34 DQALIATAISELARNIHLYAESG-KIEVKkliQEKSVGIYVIASDNGPGIPQID--ELLQK----DLATTKGIGFGLPGV 106
Cdd:cd16940    10 DALLLFLLLRNLVDNAVRYSPQGsRVEIK---LSADDGAVIRVEDNGPGIDEEEleALFERfyrsDGQNYGGSGLGLSIV 86

                          90       100
                  ....*....|....*....|....*.
gi 1724454746 107 KRIMD----EFQLDSQLTIGTTVKIK 128
Cdd:cd16940    87 KRIVElhggQIFLGNAQGGGLEAWVR 112
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
34-127 4.73e-06

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 44.51  E-value: 4.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  34 DQALIATAISELARN-IHLYAESGKIEVKKLIQEKSVGIYViaSDNGPGIP--QIDELLQ-----KDLATTKGIGFGLPG 105
Cdd:COG0642   220 DPDRLRQVLLNLLSNaIKYTPEGGTVTVSVRREGDRVRISV--EDTGPGIPpeDLERIFEpffrtDPSRRGGGTGLGLAI 297

                          90       100
                  ....*....|....*....|....*.
gi 1724454746 106 VKRIMD----EFQLDSQLTIGTTVKI 127
Cdd:COG0642   298 VKRIVElhggTIEVESEPGKGTTFTV 323
envZ PRK09467
osmolarity sensor protein; Provisional
 38-123 7.79e-06

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 43.75  E-value: 7.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  38 IATAISELARNIHLYAeSGKIEVKKLIQEKSVGIYViaSDNGPGIP--QIDELLQK----DLA-TTKGIGFGLPGVKRIM 110
Cdd:PRK09467  332 IKRALANLVVNAARYG-NGWIKVSSGTEGKRAWFQV--EDDGPGIPpeQLKHLFQPftrgDSArGSSGTGLGLAIVKRIV 408

                          90
                  ....*....|...
gi 1724454746 111 DefQLDSQLTIGT 123
Cdd:PRK09467  409 D--QHNGKVELGN 419
HATPase_SpoIIAB-like cd16942
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...
 38-129 1.18e-05

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.


Pssm-ID: 340418 [Multi-domain]  Cd Length: 135  Bit Score: 42.14  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  38 IATAISELARN--IHLYAESGK--IEVKKLIQEKSVGIYViaSDNGPGIPQIDELLQKdLATTK------GIGFGLpgVK 107
Cdd:cd16942    39 IKTVVSEAVTNaiIHGYNNDPNgiVSISVIIEDGVVHLTV--RDEGVGIPDIEEARQP-LFTTKpelersGMGFTI--ME 113

                          90       100
                  ....*....|....*....|..
gi 1724454746 108 RIMDEFQLDSQLTIGTTVKIKK 129
Cdd:cd16942   114 NFMDEVIVESEVNKGTTVYLKK 135
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
53-137 3.78e-05

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 41.88  E-value: 3.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  53 AESGKIEVKKLiQEKSVGIYVIASDNGPGIPQidELLQK---DLATTK--GIGFGLPGVKRIMD----EFQLDSQLTIGT 123
Cdd:PRK11360  517 SARGKIRIRTW-QYSDGQVAVSIEDNGCGIDP--ELLKKifdPFFTTKakGTGLGLALSQRIINahggDIEVESEPGVGT 593

                          90
                  ....*....|....
gi 1724454746 124 TVKIkkWLSINKEE 137
Cdd:PRK11360  594 TFTL--YLPINPQG 605
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 53-112 4.34e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 40.21  E-value: 4.34e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1724454746  53 AESGKIEVKKLIQEKSVG-IYVIASDNGPGIPQ--IDELLQKDLAT-TKGIGFGLPGVKRIMDE 112
Cdd:cd16944    23 RPSDVGEVRIRVEADQDGrIVLIVCDNGKGFPRemRHRATEPYVTTrPKGTGLGLAIVKKIMEE 86
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 41-127 7.61e-05

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 40.89  E-value: 7.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  41 AISELARN-IHLYAESGKIEVKKLIQEKSVGIYVIasDNGPGIPQ--IDELLQKdLATTK--GIGFGLPGVKRIMD---- 111
Cdd:COG5808   355 VLLNLIKNaIEAMKEGGKLTISIENDDEKAVIEVI--DNGEGIPEdiIDEIFEP-FVTTKegGTGLGLSVCKRIVEmhgg 431

                          90
                  ....*....|....*.
gi 1724454746 112 EFQLDSQLTIGTTVKI 127
Cdd:COG5808   432 EIDIESEEGKGTTFTI 447
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 57-125 1.00e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 38.95  E-value: 1.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1724454746  57 KIEVKklIQEKSVGIYVIASDNGPGIPQ--IDELLQKDLATTKGIGFGLPGVKRIMD-------EFQLDSQLTIGTTV 125
Cdd:cd16957    26 EVRVV--VKKDQHKVHVSVSDNGQGIPEerLDLLGKTTVTSEKGTGTALENLNRRLIglfgseaCLHIESEVHGGTEV 101
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
33-127 1.19e-04

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 40.28  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  33 IDQALIATAISELARNIHLYA-ESGKIEVKKLIQEKSVGIYVIasDNGPGIP--QIDELLQK-----DLATTKGIGFGLP 104
Cdd:COG2205   128 ADPELLEQVLANLLDNAIKYSpPGGTITISARREGDGVRISVS--DNGPGIPeeELERIFERfyrgdNSRGEGGTGLGLA 205

                          90       100
                  ....*....|....*....|....*..
gi 1724454746 105 GVKRIMD----EFQLDSQLTIGTTVKI 127
Cdd:COG2205   206 IVKRIVEahggTIWVESEPGGGTTFTV 232
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 49-127 1.02e-03

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 37.65  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  49 IHLYAESGKIEVK-KLIQEKSVGIYVIasDNGPGIPQidELLQK---DLATTK--GIGFGLPGVKRIMDEFQ----LDSQ 118
Cdd:COG5809   392 IEAMPEGGNITIEtKAEDDDKVVISVT--DEGCGIPE--ERLKKlgePFYTTKekGTGLGLMVSYKIIEEHGgkitVESE 467


                  ....*....
gi 1724454746 119 LTIGTTVKI 127
Cdd:COG5809   468 VGKGTTFSI 476
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
53-128 1.15e-03

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 37.69  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  53 AESGKIEVKklIQEKSVGIYVIASDNGPGIP--QIDELLQKDLATTKGIGFGLPGVKRIMD-------EFQLDSQLTIGT 123
Cdd:COG2972   357 EGGGTIRIS--IRKEGDRLVITVEDNGVGMPeeKLEKLLEELSSKGEGRGIGLRNVRERLKlyygeeyGLEIESEPGEGT 434


                  ....*
gi 1724454746 124 TVKIK 128
Cdd:COG2972   435 TVTIR 439
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
76-127 1.24e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 37.52  E-value: 1.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724454746  76 SDNGPGIPqiDELLQK--D-LATTK--GIGFGLPGVKRIMDE----FQLDSQLTIGTTVKI 127
Cdd:COG3852   292 IDNGPGIP--EEILDRifEpFFTTKekGTGLGLAIVQKIVEQhggtIEVESEPGKGTTFRI 350
HATPase_TopVIB-like cd16933
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
 22-127 2.53e-03

Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.


Pssm-ID: 340410 [Multi-domain]  Cd Length: 203  Bit Score: 36.17  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  22 RKEAKSIGFDIIDQALIaTAISELARNIHLYAESGKI--EVKKLIQEKSVGIY-VIASDNGPGIP--QIDELLQKDLATT 96
Cdd:cd16933     5 RKNKEMLGFDNPIRSLY-TTVRELVENSLDATEEAGIlpDIKVEIEEIGKDHYkVIVEDNGPGIPeeQIPKVFGKVLYGS 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1724454746  97 K-------GIgFGLpGVKRIMdefqLDSQLTIGTTVKI 127
Cdd:cd16933    84 KyhnkqsrGQ-QGL-GISAAV----LYSQMTTGKPVEI 115
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 38-129 2.80e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 34.94  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454746  38 IATAISELARNI--HLYAESGKIEVKKLIQEKSVGIYVIASDNGPGIPQIDeLLQKDLATTKGiGFGLPGVKRIMDEFQL 115
Cdd:cd16936     1 VELAVSEAVTNAvrHAYRHDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLR-PADPDAGLREG-GRGLALIRALMDEVGY 78

                          90
                  ....*....|....
gi 1724454746 116 DSQLTiGTTVKIKK 129
Cdd:cd16936    79 RRTPG-GKTVWLEL 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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