|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
1-408 |
3.52e-136 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 396.05 E-value: 3.52e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 1 MAFLDL-LNEDLQQ---KWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVD-GAKKATQALIVAPSQ 75
Cdd:COG0513 2 MSFADLgLSPPLLKalaELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDpSRPRAPQALILAPTR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 76 ELCMQIVEVIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRD 155
Cdd:COG0513 82 ELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDMG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 156 YRVIVKGFIDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRIKIAATEVPASgKVEHSFIKIEERDKTELLRKLSNLSG 235
Cdd:COG0513 162 FIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAE-TIEQRYYLVDKRDKLELLRRLLRDED 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 236 L-RGLAFINNLDQVMMKESKLGFRNAPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPF 314
Cdd:COG0513 241 PeRAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 315 TKEQYIHRSGRTGRAGNSGEVLTLLAHHEE------QAYLK-RMRELEIEPVEKNwANGQLKEGKAEAKPNKGNKRYSTN 387
Cdd:COG0513 321 DPEDYVHRIGRTGRAGAEGTAISLVTPDERrllraiEKLIGqKIEEEELPGFEPV-EEKRLERLKPKIKEKLKGKKAGRG 399
|
410 420
....*....|....*....|.
gi 1724454833 388 GTNANRKNKGDGKKPYHAKKR 408
Cdd:COG0513 400 GRPGPKGERKARRGKRRRRKR 420
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
13-199 |
9.26e-74 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 228.48 E-value: 9.26e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 13 QKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVD----GAKKATQALIVAPSQELCMQIVEVIRTW 88
Cdd:cd00268 6 KKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLpepkKKGRGPQALVLAPTRELAMQIAEVARKL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 89 IAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAA 168
Cdd:cd00268 86 GKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEKILSALP 165
|
170 180 190
....*....|....*....|....*....|.
gi 1724454833 169 HGRQVAVVSATVTEEIELVANRMLHDPVRIK 199
Cdd:cd00268 166 KDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
20-355 |
1.52e-72 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 234.31 E-value: 1.52e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 20 TM-PIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWIAGT-NITVV 97
Cdd:PRK11776 26 EMtPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTRELADQVAKEIRRLARFIpNIKVL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 98 PLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQVAVVS 177
Cdd:PRK11776 106 TLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 178 ATVTEEIELVANRMLHDPVRIKIAATEvpASGKVEHSFIKIEERDKTELLRKLsnLSGLR---GLAFINNLDQVMMKESK 254
Cdd:PRK11776 186 ATYPEGIAAISQRFQRDPVEVKVESTH--DLPAIEQRFYEVSPDERLPALQRL--LLHHQpesCVVFCNTKKECQEVADA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 255 LGFRNAPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGRTGRAGNSGE 334
Cdd:PRK11776 262 LNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGL 341
|
330 340
....*....|....*....|.
gi 1724454833 335 VLTLLAHHEEQaylkRMRELE 355
Cdd:PRK11776 342 ALSLVAPEEMQ----RANAIE 358
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
23-410 |
3.96e-60 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 201.32 E-value: 3.96e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 23 IQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDG--AKKATQA--LIVAPSQELCMQIVEVIRTWIAGTNITVVP 98
Cdd:PRK11192 27 IQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDfpRRKSGPPriLILTPTRELAMQVADQARELAKHTHLDIAT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 99 LIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQVAVVSA 178
Cdd:PRK11192 107 ITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILDEADRMLDMGFAQDIETIAAETRWRKQTLLFSA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 179 TVT-EEIELVANRMLHDPVRIkiaatEVPAS----GKVeHSFIKIEERD--KTELL-RKLSNLSGLRGLAFINNLDQVMM 250
Cdd:PRK11192 187 TLEgDAVQDFAERLLNDPVEV-----EAEPSrrerKKI-HQWYYRADDLehKTALLcHLLKQPEVTRSIVFVRTRERVHE 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 251 KESKLGFRNAPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGRTGRAG 330
Cdd:PRK11192 261 LAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAG 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 331 NSGEVLTLLAHHEEQAYLKRMRELEiEPVEKNWANGQLKEGKAEAKPNKGNKRYSTNGTNANRKNKGDGKKPYHAKKRGK 410
Cdd:PRK11192 341 RKGTAISLVEAHDHLLLGKIERYIE-EPLKARVIDELRPKTKAPSEKKTGKPSKKVLAKRAEKKEKEKEKPKVKKRHRDT 419
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
7-374 |
2.44e-56 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 190.42 E-value: 2.44e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 7 LNEDLQQ---KWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVE 83
Cdd:PTZ00424 35 LNEDLLRgiySYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELAQQIQK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 84 VIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGF 163
Cdd:PTZ00424 115 VVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRGFKGQIYDV 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 164 IDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRIKIAATEVPASGkVEHSFIKIEERD-KTELLRKL-SNLSGLRGLAF 241
Cdd:PTZ00424 195 FKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEG-IRQFYVAVEKEEwKFDTLCDLyETLTITQAIIY 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 242 INNLDQVMMKESKLGFRNAPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIH 321
Cdd:PTZ00424 274 CNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIH 353
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1724454833 322 RSGRTGRAGNSGEVLTLLAHHEeqayLKRMRELEiepvekNWANGQLKEGKAE 374
Cdd:PTZ00424 354 RIGRSGRFGRKGVAINFVTPDD----IEQLKEIE------RHYNTQIEEMPME 396
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
5-355 |
1.02e-54 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 187.71 E-value: 1.02e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 5 DLLNEDLQQKWKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDG------AKKATQALIVAPSQELC 78
Cdd:PRK10590 11 DILRAVAEQGYREPT--PIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITrqphakGRRPVRALILTPTRELA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 79 MQIVEVIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDY-- 156
Cdd:PRK10590 89 AQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGFih 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 157 ---RVIVKgfidgAAHGRQVAVVSATVTEEIELVANRMLHDPVRIKIAATEVpASGKVEHSFIKIEERDKTELLrklSNL 233
Cdd:PRK10590 169 dirRVLAK-----LPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNT-ASEQVTQHVHFVDKKRKRELL---SQM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 234 SGLRG----LAFI------NNLDQVMMKEsklGFRNApivALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEG 303
Cdd:PRK10590 240 IGKGNwqqvLVFTrtkhgaNHLAEQLNKD---GIRSA---AIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEE 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1724454833 304 LTHVIHVNVPFTKEQYIHRSGRTGRAGNSGEVLTLLAHHEeqayLKRMRELE 355
Cdd:PRK10590 314 LPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDE----HKLLRDIE 361
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
17-347 |
8.24e-54 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 185.50 E-value: 8.24e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 17 FPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQ-------ALIVAPSQELCMQIVEVIRTWI 89
Cdd:PRK01297 107 FPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKErymgeprALIIAPTRELVVQIAKDAAALT 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 90 AGTNITVVPLIGGANPQRQIEKLKKKPT-IVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAA 168
Cdd:PRK01297 187 KYTGLNVMTFVGGMDFDKQLKQLEARFCdILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTP 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 169 HG--RQVAVVSATVTEEIELVANRMLHDPVRIKIAATEVpASGKVEHSFIKIEERDKTELLRKLSNLSGL-RGLAFINNL 245
Cdd:PRK01297 267 RKeeRQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENV-ASDTVEQHVYAVAGSDKYKLLYNLVTQNPWeRVMVFANRK 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 246 DQVMMKESKLGFRNAPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGR 325
Cdd:PRK01297 346 DEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGR 425
|
330 340
....*....|....*....|..
gi 1724454833 326 TGRAGNSGEVLTLLAhhEEQAY 347
Cdd:PRK01297 426 TGRAGASGVSISFAG--EDDAF 445
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
18-360 |
6.31e-53 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 186.59 E-value: 6.31e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 18 PStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTW---IAGTNi 94
Cdd:PRK11634 29 PS--PIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRELAVQVAEAMTDFskhMRGVN- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 95 tVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQVA 174
Cdd:PRK11634 106 -VVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLRMGFIEDVETIMAQIPEGHQTA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 175 VVSATVTEEIELVANRMLHDP--VRIKIAATEVPasgKVEHSFIKIEERDKTE-LLRKLSNLSGLRGLAFI---NNLDQV 248
Cdd:PRK11634 185 LFSATMPEAIRRITRRFMKEPqeVRIQSSVTTRP---DISQSYWTVWGMRKNEaLVRFLEAEDFDAAIIFVrtkNATLEV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 249 MMKESKLGFRNApivALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGRTGR 328
Cdd:PRK11634 262 AEALERNGYNSA---ALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGR 338
|
330 340 350
....*....|....*....|....*....|....
gi 1724454833 329 AGNSGEVLTLLAHHEEQAY--LKRMRELEIEPVE 360
Cdd:PRK11634 339 AGRAGRALLFVENRERRLLrnIERTMKLTIPEVE 372
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
22-187 |
8.16e-48 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 160.49 E-value: 8.16e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 22 PIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWIAGTNITVVPLIG 101
Cdd:pfam00270 2 PIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 102 GANPQRQIEKLkKKPTIVVGTPGRLNELITSKKlKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQVAVVSATVT 181
Cdd:pfam00270 82 GDSRKEQLEKL-KGPDILVGTPGRLLDLLQERK-LLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATLP 159
|
....*.
gi 1724454833 182 EEIELV 187
Cdd:pfam00270 160 RNLEDL 165
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
17-339 |
5.76e-46 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 166.10 E-value: 5.76e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 17 FPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLP---------ILQKVDGAKkatqALIVAPSQELCMQIVEVIRT 87
Cdd:PTZ00110 150 FTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPaivhinaqpLLRYGDGPI----VLVLAPTRELAEQIREQCNK 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 88 WIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGA 167
Cdd:PTZ00110 226 FGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQI 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 168 AHGRQVAVVSATVTEEIELVANRML-HDPVRIKIAATEVPASGKVEHSFIKIEERDK----TELLRKLSNlSGLRGLAFI 242
Cdd:PTZ00110 306 RPDRQTLMWSATWPKEVQSLARDLCkEEPVHVNVGSLDLTACHNIKQEVFVVEEHEKrgklKMLLQRIMR-DGDKILIFV 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 243 N---NLDqVMMKESKLgfRNAPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQY 319
Cdd:PTZ00110 385 EtkkGAD-FLTKELRL--DGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDY 461
|
330 340
....*....|....*....|
gi 1724454833 320 IHRSGRTGRAGNSGEVLTLL 339
Cdd:PTZ00110 462 VHRIGRTGRAGAKGASYTFL 481
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
17-361 |
9.08e-46 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 165.89 E-value: 9.08e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 17 FPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQK-------VDGAKKATQALIVAPSQELCMQIVEVIRTWI 89
Cdd:PRK04537 29 FTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRllsrpalADRKPEDPRALILAPTRELAIQIHKDAVKFG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 90 AGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKL-KLHEINMIVLDEGDQLLS----RDYRVIVKGFI 164
Cdd:PRK04537 109 ADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVvSLHACEICVLDEADRMFDlgfiKDIRFLLRRMP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 165 DGAAhgRQVAVVSATVTEEIELVANRMLHDPVRIKIAATEVPASGKVEHSFIKIEERDKTELLRKLSNLSGLRGLAFINN 244
Cdd:PRK04537 189 ERGT--RQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEKQTLLLGLLSRSEGARTMVFVNT 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 245 ---LDQVMMKESKLGFRnapIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIH 321
Cdd:PRK04537 267 kafVERVARTLERHGYR---VGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVH 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1724454833 322 RSGRTGRAGNSGEVLTL------LAHHEEQAYLKrmRELEIEPVEK 361
Cdd:PRK04537 344 RIGRTARLGEEGDAISFaceryaMSLPDIEAYIE--QKIPVEPVTA 387
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
211-339 |
2.79e-45 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 152.66 E-value: 2.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 211 VEHSFIKIEERDKTELL--RKLSNLSGLRGLAFINNLDQVMMKESKLGFRNAPIVALHSEMKKEERKSAIERFRKGDARV 288
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLllLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1724454833 289 LLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGRTGRAGNSGEVLTLL 339
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
17-199 |
9.66e-44 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 150.87 E-value: 9.66e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 17 FPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKV---DGAKKATQALIVAPSQELCMQIVEVIRTWIAGTN 93
Cdd:cd17947 10 FTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLlyrPKKKAATRVLVLVPTRELAMQCFSVLQQLAQFTD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 94 ITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELIT-SKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQ 172
Cdd:cd17947 90 ITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRnSPSFDLDSIEILVLDEADRMLEEGFADELKEILRLCPRTRQ 169
|
170 180
....*....|....*....|....*..
gi 1724454833 173 VAVVSATVTEEIELVANRMLHDPVRIK 199
Cdd:cd17947 170 TMLFSATMTDEVKDLAKLSLNKPVRVF 196
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
16-200 |
3.07e-43 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 149.95 E-value: 3.07e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 16 KFPSTMPIQEQMVEAFLEG-KDVVAESPTGTGKTLAYLLPILQKVDgAKKATQALIVAPSQELCMQIVEVIRTWIAGTNI 94
Cdd:smart00487 5 GFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALK-RGKGGRVLVLVPTRELAEQWAEELKKLGPSLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 95 TVVPLIGGANPQRQIEKLKKKPT-IVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQV 173
Cdd:smart00487 84 KVVGLYGGDSKREQLRKLESGKTdILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQL 163
|
170 180
....*....|....*....|....*..
gi 1724454833 174 AVVSATVTEEIELVANRMLHDPVRIKI 200
Cdd:smart00487 164 LLLSATPPEEIENLLELFLNDPVFIDV 190
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
15-198 |
6.24e-41 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 143.98 E-value: 6.24e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 15 WKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWIAGTNI 94
Cdd:cd17940 19 FEKPS--PIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELALQTSQVCKELGKHMGV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 95 TVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQVA 174
Cdd:cd17940 97 KVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQDFQPIIEKILNFLPKERQIL 176
|
170 180
....*....|....*....|....
gi 1724454833 175 VVSATVTEEIELVANRMLHDPVRI 198
Cdd:cd17940 177 LFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
22-396 |
6.96e-41 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 151.86 E-value: 6.96e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 22 PIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPIL--------QKVDGAKKATqALIVAPSQELCMQIVEVIRTWIAGTN 93
Cdd:PLN00206 146 PIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIIsrcctirsGHPSEQRNPL-AMVLTPTRELCVQVEDQAKVLGKGLP 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 94 ITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGfIDGAAHGRQV 173
Cdd:PLN00206 225 FKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQ-IFQALSQPQV 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 174 AVVSATVTEEIELVANRMLHDPVRIKIAATEVPaSGKVEHSFIKIEERDKTE-LLRKLSNLSGLR--GLAFINN------ 244
Cdd:PLN00206 304 LLFSATVSPEVEKFASSLAKDIILISIGNPNRP-NKAVKQLAIWVETKQKKQkLFDILKSKQHFKppAVVFVSSrlgadl 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 245 LDQVMMKESKLgfrnaPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSG 324
Cdd:PLN00206 383 LANAITVVTGL-----KALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIG 457
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454833 325 RTGRAGNSGEVLTLLaHHEEQAYLKRMRELeiepveknwangqLKEGKAEAKPNKGNKRYSTNGTNANRKNK 396
Cdd:PLN00206 458 RASRMGEKGTAIVFV-NEEDRNLFPELVAL-------------LKSSGAAIPRELANSRYLGSGRKRKKKRR 515
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
23-198 |
9.68e-41 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 143.23 E-value: 9.68e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 23 IQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWIAGTNITVVPLIGG 102
Cdd:cd17939 23 IQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQIQKVVKALGDYMGVKVHACIGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 103 ANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQVAVVSATVTE 182
Cdd:cd17939 103 TSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFKDQIYDIFQFLPPETQVVLFSATMPH 182
|
170
....*....|....*.
gi 1724454833 183 EIELVANRMLHDPVRI 198
Cdd:cd17939 183 EVLEVTKKFMRDPVRI 198
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
18-198 |
1.44e-40 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 142.97 E-value: 1.44e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 18 PSTmpIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWIAGTNITVV 97
Cdd:cd18046 22 PSA--IQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELAQQIQKVVMALGDYMGIKCH 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 98 PLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQVAVVS 177
Cdd:cd18046 100 ACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRGFKDQIYDIFQKLPPDTQVVLLS 179
|
170 180
....*....|....*....|.
gi 1724454833 178 ATVTEEIELVANRMLHDPVRI 198
Cdd:cd18046 180 ATMPNDVLEVTTKFMRDPIRI 200
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
16-199 |
3.21e-40 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 141.94 E-value: 3.21e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 16 KFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKV-----DGAKKATQALIVAPSQELCMQIVEVIRTWIA 90
Cdd:cd17960 9 GFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILlkrkaNLKKGQVGALIISPTRELATQIYEVLQSFLE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 91 --GTNITVVPLIGGANPQRQIEKLK-KKPTIVVGTPGRLNELITSK--KLKLHEINMIVLDEGDQLL----SRDYRVIVk 161
Cdd:cd17960 89 hhLPKLKCQLLIGGTNVEEDVKKFKrNGPNILVGTPGRLEELLSRKadKVKVKSLEVLVLDEADRLLdlgfEADLNRIL- 167
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1724454833 162 gfidgaAH---GRQVAVVSATVTEEIELVANRMLHDPVRIK 199
Cdd:cd17960 168 ------SKlpkQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
15-199 |
6.67e-40 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 141.30 E-value: 6.67e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 15 WKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWIAGTNI 94
Cdd:cd17954 20 WKKPT--KIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTRELAQQISEQFEALGSSIGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 95 TVVPLIGGANPQRQIEKLKKKPTIVVGTPGRL-NELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQV 173
Cdd:cd17954 98 KSAVLVGGMDMMAQAIALAKKPHVIVATPGRLvDHLENTKGFSLKSLKFLVMDEADRLLNMDFEPEIDKILKVIPRERTT 177
|
170 180
....*....|....*....|....*.
gi 1724454833 174 AVVSATVTEEIELVANRMLHDPVRIK 199
Cdd:cd17954 178 YLFSATMTTKVAKLQRASLKNPVKIE 203
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
6-200 |
5.62e-39 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 138.49 E-value: 5.62e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 6 LLNEDLQQKWKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKV--DGAKKATQALIVAPSQELCMQIVE 83
Cdd:cd17957 1 LLNNLEESGYREPT--PIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLgkPRKKKGLRALILAPTRELASQIYR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 84 VIRTWIAGTNITVVPLIGGANP-QRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKG 162
Cdd:cd17957 79 ELLKLSKGTGLRIVLLSKSLEAkAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTDE 158
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1724454833 163 FIdgAA---HGRQVAVVSATVTEEIELVANRMLHDPVRIKI 200
Cdd:cd17957 159 IL--AActnPNLQRSLFSATIPSEVEELARSVMKDPIRIIV 197
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
15-198 |
1.50e-38 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 137.29 E-value: 1.50e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 15 WKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWIAGT-N 93
Cdd:cd17962 10 YEVPT--PIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKELMKGLpP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 94 ITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQV 173
Cdd:cd17962 88 MKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDILENISHDHQT 167
|
170 180
....*....|....*....|....*
gi 1724454833 174 AVVSATVTEEIELVANRMLHDPVRI 198
Cdd:cd17962 168 ILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
11-199 |
5.36e-38 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 136.56 E-value: 5.36e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 11 LQQKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAK------KATQALIVAPSQELCMQIVEV 84
Cdd:cd17949 5 LKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEprvdrsDGTLALVLVPTRELALQIYEV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 85 IR------TWIagtnitvVP--LIGGANpqRQIEK--LKKKPTIVVGTPGR-LNELITSKKLKLHEINMIVLDEGDQLL- 152
Cdd:cd17949 85 LEkllkpfHWI-------VPgyLIGGEK--RKSEKarLRKGVNILIATPGRlLDHLKNTQSFDVSNLRWLVLDEADRLLd 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1724454833 153 ---SRDYRVIVKGFIDGAA---------HGRQVAVVSATVTEEIELVANRMLHDPVRIK 199
Cdd:cd17949 156 mgfEKDITKILELLDDKRSkaggekskpSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
6-199 |
6.62e-38 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 135.90 E-value: 6.62e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 6 LLNEDLQQKWKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDG--AKKATQALIVAPSQELCMQIVE 83
Cdd:cd17959 12 LLRAIKKKGYKVPT--PIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAhsPTVGARALILSPTRELALQTLK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 84 VIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGF 163
Cdd:cd17959 90 VTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRLFEMGFAEQLHEI 169
|
170 180 190
....*....|....*....|....*....|....*.
gi 1724454833 164 IDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRIK 199
Cdd:cd17959 170 LSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLIR 205
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
22-196 |
9.81e-37 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 132.73 E-value: 9.81e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 22 PIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWIAGTNITVVPLIG 101
Cdd:cd17955 24 PIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRELAYQIAEQFRALGAPLGLRCCVIVG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 102 GANPQRQIEKLKKKPTIVVGTPGRLNELITS---KKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQVAVVSA 178
Cdd:cd17955 104 GMDMVKQALELSKRPHIVVATPGRLADHLRSsddTTKVLSRVKFLVLDEADRLLTGSFEDDLATILSALPPKRQTLLFSA 183
|
170
....*....|....*...
gi 1724454833 179 TVTEEIELVANRMLHDPV 196
Cdd:cd17955 184 TLTDALKALKELFGNKPF 201
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
12-200 |
2.48e-36 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 131.94 E-value: 2.48e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 12 QQKWKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKV------DGAKKATQALIVAPSQELCMQIVEVI 85
Cdd:cd17961 11 KLGWEKPT--LIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKIlkakaeSGEEQGTRALILVPTRELAQQVSKVL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 86 RTWIAGTN--ITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHE-INMIVLDEGDQLLSRDYRVIVKG 162
Cdd:cd17961 89 EQLTAYCRkdVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLStLKYLVIDEADLVLSYGYEEDLKS 168
|
170 180 190
....*....|....*....|....*....|....*...
gi 1724454833 163 FIDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRIKI 200
Cdd:cd17961 169 LLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
10-198 |
1.16e-35 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 130.58 E-value: 1.16e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 10 DLQQKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQ-----ALIVAPSQELCMQIVEV 84
Cdd:cd17953 25 DLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPVKPgegpiGLIMAPTRELALQIYVE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 85 IRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITS---KKLKLHEINMIVLDEGDQLLSRDYRVIVK 161
Cdd:cd17953 105 CKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTAnngRVTNLRRVTYVVLDEADRMFDMGFEPQIM 184
|
170 180 190
....*....|....*....|....*....|....*..
gi 1724454833 162 GFIDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRI 198
Cdd:cd17953 185 KIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
6-198 |
4.40e-34 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 125.61 E-value: 4.40e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 6 LLNEDLQQKWKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPIL-----QKVDGAKKATQALIVAPSQELCMQ 80
Cdd:cd17952 1 LLNAIRKQEYEQPT--PIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLvhimdQRELEKGEGPIAVIVAPTRELAQQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 81 IVEVIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIV 160
Cdd:cd17952 79 IYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQV 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 1724454833 161 KGFIDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRI 198
Cdd:cd17952 159 RSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
5-194 |
1.14e-33 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 125.29 E-value: 1.14e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 5 DLLNEDLQqKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKV--DGA-------KKAT-QALIVAPS 74
Cdd:cd17967 9 ELLLENIK-RAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLleDGPpsvgrgrRKAYpSALILAPT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 75 QELCMQIVEVIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLL-- 152
Cdd:cd17967 88 RELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDEADRMLdm 167
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1724454833 153 --SRDYRVIVKGFIDGAAHGRQVAVVSATVTEEIELVANRMLHD 194
Cdd:cd17967 168 gfEPQIRKIVEHPDMPPKGERQTLMFSATFPREIQRLAADFLKN 211
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
23-198 |
1.56e-33 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 124.12 E-value: 1.56e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 23 IQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWIAGTNITVVPLIGG 102
Cdd:cd18045 25 IQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELAVQIQKVLLALGDYMNVQCHACIGG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 103 ANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQVAVVSATVTE 182
Cdd:cd18045 105 TSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPQ 184
|
170
....*....|....*.
gi 1724454833 183 EIELVANRMLHDPVRI 198
Cdd:cd18045 185 DILEMTNKFMTDPIRI 200
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
22-333 |
1.79e-33 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 129.71 E-value: 1.79e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 22 PIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLP----ILQK-VDGAKKATQ--ALIVAPSQELCMQIVEVIRTWIAGTNI 94
Cdd:PRK04837 33 PIQALALPLTLAGRDVAGQAQTGTGKTMAFLTAtfhyLLSHpAPEDRKVNQprALIMAPTRELAVQIHADAEPLAQATGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 95 TVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDqllsrdyRVIVKGFIDG-------- 166
Cdd:PRK04837 113 KLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEAD-------RMFDLGFIKDirwlfrrm 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 167 -AAHGRQVAVVSATVTEEIELVANRMLHDPVRIKIAATEvpasgKVEHSfIKiEE------RDKTELLRKLsnlsgL--- 236
Cdd:PRK04837 186 pPANQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQ-----KTGHR-IK-EElfypsnEEKMRLLQTL-----Ieee 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 237 ---RGLAFINNLDQVmmkESKLGFRNAP---IVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHV 310
Cdd:PRK04837 254 wpdRAIIFANTKHRC---EEIWGHLAADghrVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNY 330
|
330 340
....*....|....*....|...
gi 1724454833 311 NVPFTKEQYIHRSGRTGRAGNSG 333
Cdd:PRK04837 331 DLPDDCEDYVHRIGRTGRAGASG 353
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
13-182 |
1.48e-32 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 122.73 E-value: 1.48e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 13 QKWKFPSTMPIQEQMV-EAFLEGKDVVAESPTGTGKTLAYLLPILQK---------VDGAKKATQALIVAPSQELCMQIV 82
Cdd:cd17946 6 ADLGFSEPTPIQALALpAAIRDGKDVIGAAETGSGKTLAFGIPILERllsqkssngVGGKQKPLRALILTPTRELAVQVK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 83 EVIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKL---KLHEINMIVLDEGDQLLSR----D 155
Cdd:cd17946 86 DHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEhlaNLKSLRFLVLDEADRMLEKghfaE 165
|
170 180 190
....*....|....*....|....*....|.
gi 1724454833 156 YRVIVKgFID----GAAHGRQVAVVSATVTE 182
Cdd:cd17946 166 LEKILE-LLNkdraGKKRKRQTFVFSATLTL 195
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
16-189 |
5.28e-32 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 120.38 E-value: 5.28e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 16 KFPSTMPIQEQMVEAFLE-GKDVVAESPTGTGKTLAYLLPILQKV-----DGAKKATQALIVAPSQELCMQIVEVIRTWI 89
Cdd:cd17964 13 GFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLlntkpAGRRSGVSALIISPTRELALQIAAEAKKLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 90 AG-TNITVVPLIGGANPQRQIEKLKK-KPTIVVGTPGRLNELI--TSKKLKLHEINMIVLDEGDQLL----SRDYRVIVK 161
Cdd:cd17964 93 QGlRKLRVQSAVGGTSRRAELNRLRRgRPDILVATPGRLIDHLenPGVAKAFTDLDYLVLDEADRLLdmgfRPDLEQILR 172
|
170 180
....*....|....*....|....*...
gi 1724454833 162 GFIDGAAHGRQVAVVSATVTEEIELVAN 189
Cdd:cd17964 173 HLPEKNADPRQTLLFSATVPDEVQQIAR 200
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
18-199 |
4.75e-31 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 117.36 E-value: 4.75e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 18 PStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWI-AGTNITV 96
Cdd:cd17943 13 PS--PIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKKIGkKLEGLKC 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 97 VPLIGGANPQRQIEKLkKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGRQVAVV 176
Cdd:cd17943 91 EVFIGGTPVKEDKKKL-KGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNWIFSSLPKNKQVIAF 169
|
170 180
....*....|....*....|...
gi 1724454833 177 SATVTEEIELVANRMLHDPVRIK 199
Cdd:cd17943 170 SATYPKNLDNLLARYMRKPVLVR 192
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
6-198 |
1.04e-30 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 116.70 E-value: 1.04e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 6 LLNEDLQQKWKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLP---------ILQKVDGAKkatqALIVAPSQE 76
Cdd:cd17966 1 VMDELKRQGFTEPT--AIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPaivhinaqpPLERGDGPI----VLVLAPTRE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 77 LCMQIVEVIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDY 156
Cdd:cd17966 75 LAQQIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGF 154
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1724454833 157 RVIVKGFIDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRI 198
Cdd:cd17966 155 EPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
17-198 |
1.37e-30 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 117.04 E-value: 1.37e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 17 FPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKAT--------QALIVAPSQELCMQIVEVIRTW 88
Cdd:cd17945 10 YKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDeetkddgpYALILAPTRELAQQIEEETQKF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 89 IAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGD------------------- 149
Cdd:cd17945 90 AKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADrmidmgfepqvtkildamp 169
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1724454833 150 -QLLSRDYRVIVKGFIDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRI 198
Cdd:cd17945 170 vSNKKPDTEEAEKLAASGKHRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
15-196 |
2.40e-30 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 115.88 E-value: 2.40e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 15 WKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVdgakkatQALIVAPSQELCMQIVEVIRTW---IAG 91
Cdd:cd17938 19 WLLPT--DIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIV-------VALILEPSRELAEQTYNCIENFkkyLDN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 92 TNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIV----KGFIDGA 167
Cdd:cd17938 90 PKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQGNLETInriyNRIPKIT 169
|
170 180 190
....*....|....*....|....*....|..
gi 1724454833 168 AHGR--QVAVVSATV-TEEIELVANRMLHDPV 196
Cdd:cd17938 170 SDGKrlQVIVCSATLhSFEVKKLADKIMHFPT 201
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
13-198 |
2.90e-30 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 115.25 E-value: 2.90e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 13 QKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVD------GAKKATQALIVAPSQELCMQIVEVIR 86
Cdd:cd17958 6 KKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDlqpiprEQRNGPGVLVLTPTRELALQIEAECS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 87 TWiAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDG 166
Cdd:cd17958 86 KY-SYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIRKILLD 164
|
170 180 190
....*....|....*....|....*....|..
gi 1724454833 167 AAHGRQVAVVSATVTEEIELVANRMLHDPVRI 198
Cdd:cd17958 165 IRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
23-200 |
2.64e-29 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 113.21 E-value: 2.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 23 IQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIV-EVIRTWIAGTNITVVPLIG 101
Cdd:cd17950 28 VQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTRELAFQISnEYERFSKYMPNVKTAVFFG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 102 GANPQRQIEKLKKK-PTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLL-SRDYRVIVKGFIDGAAHGRQVAVVSAT 179
Cdd:cd17950 108 GVPIKKDIEVLKNKcPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLeQLDMRRDVQEIFRATPHDKQVMMFSAT 187
|
170 180
....*....|....*....|.
gi 1724454833 180 VTEEIELVANRMLHDPVRIKI 200
Cdd:cd17950 188 LSKEIRPVCKKFMQDPLEIFV 208
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
3-193 |
2.77e-29 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 114.68 E-value: 2.77e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 3 FLDLLNEDLQqKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQK-----VDGAK----KATQALIVAP 73
Cdd:cd18052 50 LCETLLKNIR-KAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGmmkegLTASSfsevQEPQALIVAP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 74 SQELCMQIVEVIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLS 153
Cdd:cd18052 129 TRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLKYLILDEADRMLD 208
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1724454833 154 R----DYRVIVKGFIDGAAHGRQVAVVSATVTEEIELVANRMLH 193
Cdd:cd18052 209 MgfgpEIRKLVSEPGMPSKEDRQTLMFSATFPEEIQRLAAEFLK 252
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
13-195 |
6.85e-29 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 112.73 E-value: 6.85e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 13 QKWKFPSTMPIQEQMVEAFLEG---------KDVVAESPTGTGKTLAYLLPILQKV-DGAKKATQALIVAPSQELCMQIV 82
Cdd:cd17956 6 QNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALsKRVVPRLRALIVVPTKELVQQVY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 83 EVIRTWIAGTNITVVPLIGG---ANPQRQIEK-----LKKKPTIVVGTPGRLNELITSKK-LKLHEINMIVLDEGDQLLS 153
Cdd:cd17956 86 KVFESLCKGTGLKVVSLSGQksfKKEQKLLLVdtsgrYLSRVDILVATPGRLVDHLNSTPgFTLKHLRFLVIDEADRLLN 165
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454833 154 RDY---------------RVIVKGFIDGAAHGRQVA-----VVSATVTEEIELVANRMLHDP 195
Cdd:cd17956 166 QSFqdwletvmkalgrptAPDLGSFGDANLLERSVRplqklLFSATLTRDPEKLSSLKLHRP 227
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
222-330 |
1.02e-27 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 105.76 E-value: 1.02e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 222 DKTELLRK-LSNLSGLRGLAFINNldQVMMKESKLGFR-NAPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGL 299
Cdd:pfam00271 1 EKLEALLElLKKERGGKVLIFSQT--KKTLEAELLLEKeGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 1724454833 300 DIEGLTHVIHVNVPFTKEQYIHRSGRTGRAG 330
Cdd:pfam00271 79 DLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
14-199 |
1.19e-27 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 108.43 E-value: 1.19e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 14 KWKFPSTmpIQEQMVEAFLEG--KDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWIAG 91
Cdd:cd17963 13 GFNKPSK--IQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQIGEVVEKMGKF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 92 TNITVVPLIGGANPQRQiEKLKKKptIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLS----RDYRVIVKGFIdga 167
Cdd:cd17963 91 TGVKVALAVPGNDVPRG-KKITAQ--IVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDtqghGDQSIRIKRML--- 164
|
170 180 190
....*....|....*....|....*....|..
gi 1724454833 168 AHGRQVAVVSATVTEEIELVANRMLHDPVRIK 199
Cdd:cd17963 165 PRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
16-198 |
1.19e-26 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 105.45 E-value: 1.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 16 KFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKV--------DGakkaTQALIVAPSQELCMQIVEVIRT 87
Cdd:cd17941 9 GFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLyrerwtpeDG----LGALIISPTRELAMQIFEVLRK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 88 WIAGTNITVVPLIGGANPQRQIEKLKKKpTIVVGTPGR-LNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDG 166
Cdd:cd17941 85 VGKYHSFSAGLIIGGKDVKEEKERINRM-NILVCTPGRlLQHMDETPGFDTSNLQMLVLDEADRILDMGFKETLDAIVEN 163
|
170 180 190
....*....|....*....|....*....|..
gi 1724454833 167 AAHGRQVAVVSATVTEEIELVANRMLHDPVRI 198
Cdd:cd17941 164 LPKSRQTLLFSATQTKSVKDLARLSLKNPEYI 195
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
16-188 |
2.28e-26 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 104.75 E-value: 2.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 16 KFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAK----KATQALIVAPSQELCMQIVEVIRTWIAG 91
Cdd:cd17942 9 GFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKfkprNGTGVIIISPTRELALQIYGVAKELLKY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 92 TNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGR-LNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHG 170
Cdd:cd17942 89 HSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRlLDHLQNTKGFLYKNLQCLIIDEADRILEIGFEEEMRQIIKLLPKR 168
|
170
....*....|....*...
gi 1724454833 171 RQVAVVSATVTEEIELVA 188
Cdd:cd17942 169 RQTMLFSATQTRKVEDLA 186
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
12-202 |
2.62e-26 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 105.86 E-value: 2.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 12 QQKWKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLP---------ILQKVDGAKkatqALIVAPSQELCMQIV 82
Cdd:cd18049 41 RQNFTEPT--AIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPaivhinhqpFLERGDGPI----CLVLAPTRELAQQVQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 83 EVIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKG 162
Cdd:cd18049 115 QVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRK 194
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1724454833 163 FIDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRIKIAA 202
Cdd:cd18049 195 IVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGA 234
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
252-330 |
4.12e-26 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 100.36 E-value: 4.12e-26
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1724454833 252 ESKLGFRNAPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGRTGRAG 330
Cdd:smart00490 4 AELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
4-201 |
2.53e-25 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 103.94 E-value: 2.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 4 LDLLnedLQQKWKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPI---------LQKVDGAKkatqALIVAPS 74
Cdd:cd18050 74 MDVL---LDQNFKEPT--PIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAivhinhqpyLERGDGPI----CLVLAPT 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 75 QELCMQIVEVIRTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSR 154
Cdd:cd18050 145 RELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDM 224
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1724454833 155 DYRVIVKGFIDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRIKIA 201
Cdd:cd18050 225 GFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINIG 271
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
12-198 |
2.42e-24 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 99.72 E-value: 2.42e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 12 QQKWKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLP-ILQKVDGAKKAT-------QALIVAPSQELCMQIVE 83
Cdd:cd17951 7 KKGIKKPT--PIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPlIMFALEQEKKLPfikgegpYGLIVCPSRELARQTHE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 84 VIRTWIAGTNITVVP------LIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYR 157
Cdd:cd17951 85 VIEYYCKALQEGGYPqlrcllCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMIDMGFE 164
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1724454833 158 VIVKGFIDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRI 198
Cdd:cd17951 165 EDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
7-193 |
1.10e-23 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 98.59 E-value: 1.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 7 LNEDLQQK-WKFPSTmpIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQ-------ALIVAPSQELC 78
Cdd:cd17948 1 LVEILQRQgITKPTT--VQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEgpfnaprGLVITPSRELA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 79 MQIVEVIRTWIAGTNItVVPLIGGANPQRQIEKLK-KKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDY- 156
Cdd:cd17948 79 EQIGSVAQSLTEGLGL-KVKVITGGRTKRQIRNPHfEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFn 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454833 157 ---RVIVKGF---------IDGAAHGRQVAVVSATV-------------TEEIELVANRMLH 193
Cdd:cd17948 158 eklSHFLRRFplasrrsenTDGLDPGTQLVLVSATMpsgvgevlskvidVDSIETVTSDKLH 219
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
22-152 |
7.34e-22 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 92.60 E-value: 7.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 22 PIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAK------KATQALIVAPSQELCMQIVEVIRTwiAGTNIT 95
Cdd:cd17944 15 PIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQqprkrgRAPKVLVLAPTRELANQVTKDFKD--ITRKLS 92
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1724454833 96 VVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLL 152
Cdd:cd17944 93 VACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQML 149
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
22-194 |
7.94e-22 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 93.57 E-value: 7.94e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 22 PIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKV--DGAKKATQ--------------ALIVAPSQELCMQIVEVI 85
Cdd:cd18051 46 PVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIyeQGPGESLPsesgyygrrkqyplALVLAPTRELASQIYDEA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 86 RTWIAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDY----RVIVK 161
Cdd:cd18051 126 RKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGKIGLDYCKYLVLDEADRMLDMGFepqiRRIVE 205
|
170 180 190
....*....|....*....|....*....|...
gi 1724454833 162 GFIDGAAHGRQVAVVSATVTEEIELVANRMLHD 194
Cdd:cd18051 206 QDTMPPTGERQTLMFSATFPKEIQMLARDFLDN 238
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
22-360 |
6.10e-20 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 92.01 E-value: 6.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 22 PIQEQMVEAFL-----EGKDVVAESPTGTGKTLAYLLpILQKVDGAKKAtqaLIVAPSQELCMQIVEVIRTWIagtnitv 96
Cdd:COG1061 83 PYQQEALEALLaalerGGGRGLVVAPTGTGKTVLALA-LAAELLRGKRV---LVLVPRRELLEQWAEELRRFL------- 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 97 vPLIGGANPQRQIEKlkkkpTIVVGTPGRLNELITSKKLKlHEINMIVLDEGDQLLSRDYRVIVKGFIDGAAHGrqvavV 176
Cdd:COG1061 152 -GDPLAGGGKKDSDA-----PITVATYQSLARRAHLDELG-DRFGLVIIDEAHHAGAPSYRRILEAFPAAYRLG-----L 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 177 SAT----------------VTEEI---ELVANRMLHDPVRIKI------AATEVPASGKVEHSFIKIEERDKTELLRKL- 230
Cdd:COG1061 220 TATpfrsdgreillflfdgIVYEYslkEAIEDGYLAPPEYYGIrvdltdERAEYDALSERLREALAADAERKDKILRELl 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 231 -SNLSGLRGLAFINNLDQV-MMKEsKLGFRNAPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVI 308
Cdd:COG1061 300 rEHPDDRKTLVFCSSVDHAeALAE-LLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI 378
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1724454833 309 HVNVPFTKEQYIHRSGRTGRAGNSGEVLTLL-----AHHEEQAYLKRMRELEIEPVE 360
Cdd:COG1061 379 LLRPTGSPREFIQRLGRGLRPAPGKEDALVYdfvgnDVPVLEELAKDLRDLAGYRVE 435
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
34-179 |
1.33e-18 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 81.68 E-value: 1.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 34 GKDVVAESPTGTGKTLAYLLPILQkvDGAKKATQALIVAPSQELCMQIVEVIRTWiAGTNITVVPLIGGANPQRQIEKLK 113
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALL--LLLKKGKKVLVLVPTKALALQTAERLREL-FGPGIRVAVLVGGSSAEEREKNKL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1724454833 114 KKPTIVVGTPGRLNELITS-KKLKLHEINMIVLDE-------GDQLLSRDYRVIVKGFidgaaHGRQVAVVSAT 179
Cdd:cd00046 78 GDADIIIATPDMLLNLLLReDRLFLKDLKLIIVDEahallidSRGALILDLAVRKAGL-----KNAQVILLSAT 146
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
23-205 |
6.98e-17 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 79.29 E-value: 6.98e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 23 IQEQMVEAFLEG--KDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQ---IVEVIRTWIAGtnITVV 97
Cdd:cd18048 44 IQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLSPTFELALQtgkVVEEMGKFCVG--IQVI 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 98 PLIGGANPQR--QIEKlkkkpTIVVGTPGR-LNELITSKKLKLHEINMIVLDEGDQLLSrdyrviVKGFIDGAAHGR--- 171
Cdd:cd18048 122 YAIRGNRPGKgtDIEA-----QIVIGTPGTvLDWCFKLRLIDVTNISVFVLDEADVMIN------VQGHSDHSVRVKrsm 190
|
170 180 190
....*....|....*....|....*....|....*...
gi 1724454833 172 ----QVAVVSATVTEEIELVANRMLHDPVRIKIAATEV 205
Cdd:cd18048 191 pkecQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEEL 228
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
24-341 |
2.61e-15 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 77.95 E-value: 2.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 24 QEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATqALIVAP----SQElcmQiVEVIRTWI--AGTNITVV 97
Cdd:COG1205 61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPGAT-ALYLYPtkalARD---Q-LRRLRELAeaLGLGVRVA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 98 PLIGGAnPQRQIEKLKKKPTIVVGTPGRLNELITS---------KKLKLheinmIVLDE--------GD---QLLSRDYR 157
Cdd:COG1205 136 TYDGDT-PPEERRWIREHPDIVLTNPDMLHYGLLPhhtrwarffRNLRY-----VVIDEahtyrgvfGShvaNVLRRLRR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 158 VIvkgfidgAAHGRQVAVV--SATVTEEIELvANRMLHDPVRIkIAATEVPaSGKVEHSFIKIEERDKT----------E 225
Cdd:COG1205 210 IC-------RHYGSDPQFIlaSATIGNPAEH-AERLTGRPVTV-VDEDGSP-RGERTFVLWNPPLVDDGirrsalaeaaR 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 226 LLRKLSNlSGLRGLAFIN--NLDQVMMKESKLGFRNAP----IVALHSEMKKEERKsAIER-FRKGDARVLLAT------ 292
Cdd:COG1205 280 LLADLVR-EGLRTLVFTRsrRGAELLARYARRALREPDladrVAAYRAGYLPEERR-EIERgLRSGELLGVVSTnalelg 357
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1724454833 293 -DIAarGLDIeglthVIHVNVPFTKEQYIHRSGRTGRAGNSGEVLTLLAH 341
Cdd:COG1205 358 iDIG--GLDA-----VVLAGYPGTRASFWQQAGRAGRRGQDSLVVLVAGD 400
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
12-198 |
2.91e-15 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 75.11 E-value: 2.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 12 QQKWKFPSTMPIQEQMVEAFLegkdVVAEspTGTGKTLAYLLPIL---------------QKVDGAKKATQ--ALIVAPS 74
Cdd:cd17965 45 TLMRKVTKQTSNEEPKLEVFL----LAAE--TGSGKTLAYLAPLLdylkrqeqepfeeaeEEYESAKDTGRprSVILVPT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 75 QELCMQIVEVIRTW--IAGTNITVVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGDQLL 152
Cdd:cd17965 119 HELVEQVYSVLKKLshTVKLGIKTFSSGFGPSYQRLQLAFKGRIDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLF 198
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1724454833 153 SRDYRVIVKGFIDGAAHGRQVAVVSATVTEEIELVANRMLHDPVRI 198
Cdd:cd17965 199 DRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRKLFPDVVRI 244
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
23-199 |
1.30e-14 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 72.06 E-value: 1.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 23 IQEQMVEAFLEG--KDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIVAPSQELCMQIVEVIRTwiAGTNITVVPLI 100
Cdd:cd18047 27 IQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGKVIEQ--MGKFYPELKLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 101 GGANPQRQIEKLKKKPTIVVGTPGR-LNELITSKKLKLHEINMIVLDEGDQLLS----RDYRVIVKGFIdgaAHGRQVAV 175
Cdd:cd18047 105 YAVRGNKLERGQKISEQIVIGTPGTvLDWCSKLKFIDPKKIKVFVLDEADVMIAtqghQDQSIRIQRML---PRNCQMLL 181
|
170 180
....*....|....*....|....
gi 1724454833 176 VSATVTEEIELVANRMLHDPVRIK 199
Cdd:cd18047 182 FSATFEDSVWKFAQKVVPDPNVIK 205
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
34-188 |
5.63e-11 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 60.67 E-value: 5.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 34 GKDVVAESPTGTGKTLAYLLPILQKV-DGAKKATQALIVAPSQELCMQIVEVIRTWIAGTN--ITVVPLIGGANPQRQIE 110
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLaDEPEKGVQVLYISPLKALINDQERRLEEPLDEIDleIPVAVRHGDTSQSEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 111 KLKKKPTIVVGTPGRLNELITSKKL--KLHEINMIVLDE---------GDQLLSRDYRvivkgfIDGAAHGRQVAV-VSA 178
Cdd:cd17922 81 QLKNPPGILITTPESLELLLVNKKLreLFAGLRYVVVDEihallgskrGVQLELLLER------LRKLTGRPLRRIgLSA 154
|
170
....*....|
gi 1724454833 179 TVtEEIELVA 188
Cdd:cd17922 155 TL-GNLEEAA 163
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
12-360 |
4.65e-10 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 61.66 E-value: 4.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 12 QQKWKFPStmPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQ------KVDGAKKATQALIVAP------------ 73
Cdd:COG1201 19 AARFGAPT--PPQREAWPAIAAGESTLLIAPTGSGKTLAAFLPALDelarrpRPGELPDGLRVLYISPlkalandiernl 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 74 -------SQELCMQIVEV---IRTwiagtnitvvpligGANPQRQIEKLKKK-PTIVVGTPGRLNELITSKKL--KLHEI 140
Cdd:COG1201 97 rapleeiGEAAGLPLPEIrvgVRT--------------GDTPASERQRQRRRpPHILITTPESLALLLTSPDAreLLRGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 141 NMIVLDE---------GDQL---LSR-------DYRVI-----------VKGFIDGAAHGRQVAVVSATVTEEIELvanR 190
Cdd:COG1201 163 RTVIVDEihalagskrGVHLalsLERlralaprPLQRIglsatvgpleeVARFLVGYEDPRPVTIVDAGAGKKPDL---E 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 191 MLhDPVRIKIAAteVPASGkveHSFIKIEERDKTELLRKLSNlsglrgLAFINNLDQVmmkE---SKLGFRNA----PIV 263
Cdd:COG1201 240 VL-VPVEDLIER--FPWAG---HLWPHLYPRVLDLIEAHRTT------LVFTNTRSQA---ErlfQRLNELNPedalPIA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 264 ALHSEMKKEERKSAIERFRKGDARVLLAT-------DIAArgLDIeglthVIHVNVPftKE-----QYI----HRSGRTG 327
Cdd:COG1201 305 AHHGSLSREQRLEVEEALKAGELRAVVATsslelgiDIGD--VDL-----VIQVGSP--KSvarllQRIgragHRVGEVS 375
|
410 420 430
....*....|....*....|....*....|....*..
gi 1724454833 328 RA----GNSGEVLtllahhEEQAYLKRMRELEIEPVE 360
Cdd:COG1201 376 KGrlvpTHRDELV------ECAAALEAARAGEIEARR 406
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
22-147 |
6.35e-10 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 58.04 E-value: 6.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 22 PIQEQMVE-AFLEGKDVVAESPTGTGKTLAYLLPILQKVdgAKKATQALIVAPSQELCMQIVEVIRTWIAGTNITVVPLI 100
Cdd:cd17921 4 PIQREALRaLYLSGDSVLVSAPTSSGKTLIAELAILRAL--ATSGGKAVYIAPTRALVNQKEADLRERFGPLGKNVGLLT 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1724454833 101 GgaNPQRQIEKLKKKPtIVVGTPGRL-NELITSKKLKLHEINMIVLDE 147
Cdd:cd17921 82 G--DPSVNKLLLAEAD-ILVATPEKLdLLLRNGGERLIQDVRLVVVDE 126
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
22-365 |
7.28e-10 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 60.68 E-value: 7.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 22 PIQEQMVEA-FLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKatqALIVAPSQELCMQIVEVIRTWIAGTNITVVPLI 100
Cdd:COG1204 25 PPQAEALEAgLLEGKNLVVSAPTASGKTLIAELAILKALLNGGK---ALYIVPLRALASEKYREFKRDFEELGIKVGVST 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 101 GGANPQrqiEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDEGdQLLSRDYR------VIVKgfIDGAAHGRQVA 174
Cdd:COG1204 102 GDYDSD---DEWLGRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEA-HLIDDESRgptlevLLAR--LRRLNPEAQIV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 175 VVSATV--TEEI----------------ELVANRMLHDPVR------------IKIAATEVPASGKV---EHSfikieeR 221
Cdd:COG1204 176 ALSATIgnAEEIaewldaelvksdwrpvPLNEGVLYDGVLRfddgsrrskdptLALALDLLEEGGQVlvfVSS------R 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 222 DKTE-LLRKLSNLSGLRGLAFI-NNLDQVM------MKESKLGFRNAPIVAL-----HSEMKKEERkSAIER-FRKGDAR 287
Cdd:COG1204 250 RDAEsLAKKLADELKRRLTPEErEELEELAeellevSEETHTNEKLADCLEKgvafhHAGLPSELR-RLVEDaFREGLIK 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 288 VLLATDIAARGL----------DIEGLThvihvNVPFTKEQYIHRSGRTGRAG--NSGEVLTLLAHHEEQAYLKRMREL- 354
Cdd:COG1204 329 VLVATPTLAAGVnlparrviirDTKRGG-----MVPIPVLEFKQMAGRAGRPGydPYGEAILVAKSSDEADELFERYILg 403
|
410
....*....|.
gi 1724454833 355 EIEPVEKNWAN 365
Cdd:COG1204 404 EPEPIRSKLAN 414
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
24-147 |
7.33e-10 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 58.05 E-value: 7.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 24 QEQMVEAFLEgKDVVAESPTGTGKTLAYLLPILQ------KVDGAKKatQALIVAPSQELCMQIVEVIRTWiagTNITVV 97
Cdd:cd18034 7 QLELFEAALK-RNTIVVLPTGSGKTLIAVMLIKEmgelnrKEKNPKK--RAVFLVPTVPLVAQQAEAIRSH---TDLKVG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1724454833 98 PLIGGANPQRQIEKLKK----KPTIVVGTPGRLNELITSKKLKLHEINMIVLDE 147
Cdd:cd18034 81 EYSGEMGVDKWTKERWKeeleKYDVLVMTAQILLDALRHGFLSLSDINLLIFDE 134
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
269-340 |
6.43e-09 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 57.82 E-value: 6.43e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724454833 269 MKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVI-HVNVPfTKEQYIHRSGRTGRaGNSGEVLTLLA 340
Cdd:COG1111 395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIfYEPVP-SEIRSIQRKGRTGR-KREGRVVVLIA 465
|
|
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
11-361 |
8.10e-09 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 57.09 E-value: 8.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 11 LQQKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQkVDGAkkatqALIVAPSQELCMQIVEVIRTwia 90
Cdd:TIGR00614 3 LKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALY-SDGI-----TLVISPLISLMEDQVLQLQA--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 91 gTNITVVpLIGGA---NPQRQIE---KLKKKPTIVVgTPGRlneLITSKKL--KLHE---INMIVLDEGdQLLSR----- 154
Cdd:TIGR00614 74 -LGIPAT-FLNSAqtkEQQLNVLtdlKDGKIKLLYV-TPEK---ISASNRLlqTLEErkgITLIAVDEA-HCISQwghdf 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 155 --DYRVIvkGFIDGAAHGRQVAVVSATVTEEIELVANRML--HDPvRIKIAATEVP-ASGKVEHSFIKIEErDKTELLRK 229
Cdd:TIGR00614 147 rpDYKAL--GSLKQKFPNVPVMALTATASPSVREDILRQLnlLNP-QIFCTSFDRPnLYYEVRRKTPKILE-DLLRFIRK 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 230 lsNLSGLRGLAFINN---LDQVMMKESKLGFRNApivALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTH 306
Cdd:TIGR00614 223 --EFEGKSGIIYCPSrkkVEQVAAELQKLGLAAG---AYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGMGINKPDVRF 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1724454833 307 VIHVNVPFTKEQYIHRSGRTGRAGNSGEVLTLLAHHeEQAYLKRMreLEIEPVEK 361
Cdd:TIGR00614 298 VIHYSLPKSMESYYQESGRAGRDGLPSECHLFYAPA-DMNRLRRL--LMEEPDGN 349
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
11-353 |
1.44e-08 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 56.65 E-value: 1.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 11 LQQKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKvDGAkkatqALIVAPSQELCMQIVEVIRtwia 90
Cdd:PRK11057 17 LQETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVL-DGL-----TLVVSPLISLMKDQVDQLL---- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 91 GTNITVVPLIGGANPQRQIEKLKK----KPTIVVGTPGRLneLITSKKLKLHEIN--MIVLDEGdQLLSR---DYRVIVK 161
Cdd:PRK11057 87 ANGVAAACLNSTQTREQQLEVMAGcrtgQIKLLYIAPERL--MMDNFLEHLAHWNpaLLAVDEA-HCISQwghDFRPEYA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 162 GFIDGAAHGRQVAVVSATVTEE----IELVANRMLHDPVrIKIAATEVPasgKVEHSFIkieERDK--TELLRKLSNLSG 235
Cdd:PRK11057 164 ALGQLRQRFPTLPFMALTATADdttrQDIVRLLGLNDPL-IQISSFDRP---NIRYTLV---EKFKplDQLMRYVQEQRG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 236 LRGLAFINNLDQVMMKESKLGFRNAPIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFT 315
Cdd:PRK11057 237 KSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRN 316
|
330 340 350
....*....|....*....|....*....|....*...
gi 1724454833 316 KEQYIHRSGRTGRAGNSGEVLtLLAHHEEQAYLKRMRE 353
Cdd:PRK11057 317 IESYYQETGRAGRDGLPAEAM-LFYDPADMAWLRRCLE 353
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
24-83 |
2.16e-08 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 56.09 E-value: 2.16e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 24 QEQMVE----AFLEGKDVVAESPTGTGKTLAYLLP-ILQKVDGAKK-----ATQALivapsQElcmQIVE 83
Cdd:COG1199 19 QREMAEavarALAEGRHLLIEAGTGTGKTLAYLVPaLLAARETGKKvvistATKAL-----QE---QLVE 80
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
288-333 |
2.42e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.78 E-value: 2.42e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1724454833 288 VLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGRTGRAGNSG 333
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDE 70
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
24-147 |
4.68e-08 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 52.59 E-value: 4.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 24 QEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVdGAKKATQALIVAPSQELCMQIVEVIRTWIA--GTNITVVPLIG 101
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEAL-LRDPGSRALYLYPTKALAQDQLRSLRELLEqlGLGIRVATYDG 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1724454833 102 GANPQRQIEKLKKKPTIVVGTPGRLNELIT---------SKKLKLheinmIVLDE 147
Cdd:cd17923 84 DTPREERRAIIRNPPRILLTNPDMLHYALLphhdrwarfLRNLRY-----VVLDE 133
|
|
| DEXH_lig_assoc |
TIGR04121 |
DEXH box helicase, DNA ligase-associated; Members of this protein family are DEAD/DEAH box ... |
22-195 |
7.01e-08 |
|
DEXH box helicase, DNA ligase-associated; Members of this protein family are DEAD/DEAH box helicases found associated with a bacterial ATP-dependent DNA ligase, part of a four-gene system that occurs in about 12 % of prokaryotic reference genomes. The actual motif in this family is DE[VILW]H.
Pssm-ID: 274994 [Multi-domain] Cd Length: 804 Bit Score: 54.48 E-value: 7.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 22 PIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKAT----QALIVAPSQELCMQIVEVIRTWIA--GTNIT 95
Cdd:TIGR04121 16 PFQLEMWAAALEGRSGLLIAPTGSGKTLAGFLPSLIDLAGPEAPKekglHTLYITPLRALAVDIARNLQAPIEelGLPIR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 96 VVPLIGGANPQRQIEKLKKKPTIVVGTPGRLNELITS-------KKLKlheinMIVLDE---------GDQL---LSRdy 156
Cdd:TIGR04121 96 VETRTGDTSSSERARQRKKPPDILLTTPESLALLLSYpdaarlfKDLR-----CVVVDEwhelagskrGDQLelaLAR-- 168
|
170 180 190
....*....|....*....|....*....|....*....
gi 1724454833 157 rvivkgfIDGAAHGRQVAVVSATVtEEIELVANRMLHDP 195
Cdd:TIGR04121 169 -------LRRLAPGLRRWGLSATI-GNLEEARRVLLGVG 199
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
267-332 |
7.37e-08 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 51.05 E-value: 7.37e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1724454833 267 SEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGRtGRAGNS 332
Cdd:cd18802 72 SLMTQRKQKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARAPNS 136
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
8-147 |
2.51e-07 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 50.49 E-value: 2.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 8 NEDLQQKW--KFP-STMPIQEQMVEAFLegKDVVAESP--------TGTGKTLAYLLPILQKVDGAKkatQALIVAPSQE 76
Cdd:cd17918 1 DRALIQELckSLPfSLTKDQAQAIKDIE--KDLHSPEPmdrllsgdVGSGKTLVALGAALLAYKNGK---QVAILVPTEI 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724454833 77 LCMQIVEVIRTWIAgtNITVVPLIGGANpqrqiEKLKKKPTIVVGTPGRLNElitskKLKLHEINMIVLDE 147
Cdd:cd17918 76 LAHQHYEEARKFLP--FINVELVTGGTK-----AQILSGISLLVGTHALLHL-----DVKFKNLDLVIVDE 134
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
269-339 |
2.81e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 49.66 E-value: 2.81e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724454833 269 MKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGRTGRaGNSGEVLTLL 339
Cdd:cd18801 74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR-KRQGRVVVLL 143
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
269-410 |
6.46e-07 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 51.41 E-value: 6.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 269 MKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVI-HVNVPfTKEQYIHRSGRTGRaGNSGEVLTLLAH------ 341
Cdd:PRK13766 407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIfYEPVP-SEIRSIQRKGRTGR-QEEGRVVVLIAKgtrdea 484
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1724454833 342 ------HEEQAYLKRMRELEIEPVEKNWANGQLKEGKAEAKPNKGNKRYSTNGTNANRKNKGDGKKPYHAKKRGK 410
Cdd:PRK13766 485 yywssrRKEKKMKEELKNLKGILNKKLQELDEEQKGEEEEKDEQLSLDDFVKSKGKEEEEEEEKEEKDKETEEDE 559
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
9-147 |
1.00e-06 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 49.07 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 9 EDLQQKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLP--ILQKVdgakkatqALIVAP--S--QELCMQIV 82
Cdd:cd17920 2 QILKEVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPalLLDGV--------TLVVSPliSlmQDQVDRLQ 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1724454833 83 EvirtwiagTNITVVPLIGGANP--QRQIEKLKKKP--TIVVGTPGRLN-----ELITSKKlKLHEINMIVLDE 147
Cdd:cd17920 74 Q--------LGIRAAALNSTLSPeeKREVLLRIKNGqyKLLYVTPERLLspdflELLQRLP-ERKRLALIVVDE 138
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
21-147 |
1.72e-06 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 48.10 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 21 MPIQEQMVEA-FLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKatqALIVAPSQELCMQIVEVIRTWiAGTNITVVPL 99
Cdd:cd18028 3 YPPQAEAVRAgLLKGENLLISIPTASGKTLIAEMAMVNTLLEGGK---ALYLVPLRALASEKYEEFKKL-EEIGLKVGIS 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1724454833 100 IGGANpqRQIEKLKKKPtIVVGTPGRLNELITSKKLKLHEINMIVLDE 147
Cdd:cd18028 79 TGDYD--EDDEWLGDYD-IIVATYEKFDSLLRHSPSWLRDVGVVVVDE 123
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
261-332 |
6.02e-06 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 45.72 E-value: 6.02e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454833 261 PIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGRTGRAGNS 332
Cdd:cd18796 70 FIALHHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRPGA 141
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
23-147 |
8.27e-06 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 45.97 E-value: 8.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 23 IQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDgaKKATQALIVAPSQELCMQIVEVIRTwIAGTNITVVPLIGG 102
Cdd:cd18035 5 LYQVLIAAVALNGNTLIVLPTGLGKTIIAILVAADRLT--KKGGKVLILAPSRPLVEQHAENLKR-VLNIPDKITSLTGE 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1724454833 103 ANPQRQiEKLKKKPTIVVGTPGRLNELITSKKLKLHEINMIVLDE 147
Cdd:cd18035 82 VKPEER-AERWDASKIIVATPQVIENDLLAGRITLDDVSLLIFDE 125
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
252-329 |
8.33e-06 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 45.16 E-value: 8.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 252 ESKLGFRNAPIVALHSEMKKEERKSAIERFRKGDA--RVLLATDIAARGLDIEGLTHVIHV----NvPFTKEQyihrsgR 325
Cdd:cd18793 44 EEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDirVFLLSTKAGGVGLNLTAANRVILYdpwwN-PAVEEQ------A 116
|
....
gi 1724454833 326 TGRA 329
Cdd:cd18793 117 IDRA 120
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
11-73 |
9.05e-06 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 46.10 E-value: 9.05e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724454833 11 LQQKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDgaKKATQALIVAP 73
Cdd:cd18018 4 LRRVFGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLLRR--RGPGLTLVVSP 64
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
216-332 |
9.85e-06 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 44.94 E-value: 9.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 216 IKIEERDKTELLRKLSNL--SGLRGLAFIN--NLDQVMMKESKLGF----RNAPIVALH-SEMKKEERKsAIER-FRKGD 285
Cdd:cd18797 14 DGERGSARREAARLFADLvrAGVKTIVFCRsrKLAELLLRYLKARLveegPLASKVASYrAGYLAEDRR-EIEAeLFNGE 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1724454833 286 ARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGRTGRAGNS 332
Cdd:cd18797 93 LLGVVATNALELGIDIGGLDAVVLAGYPGSLASLWQQAGRAGRRGKD 139
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
7-338 |
4.02e-05 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 45.52 E-value: 4.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 7 LNEDLQQKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPilqkvdgakkatqALIvapsqelcmqivevir 86
Cdd:COG0514 5 ALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLP-------------ALL---------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 87 twIAGTniTVV--PLIggANPQRQIEKLKKKptivvGTP-GRLN------------ELITSKKLKL-------------- 137
Cdd:COG0514 56 --LPGL--TLVvsPLI--ALMKDQVDALRAA-----GIRaAFLNsslsaeerrevlRALRAGELKLlyvaperllnprfl 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 138 -----HEINMIVLDE-------GDQLlsR-DYRVIvkgfidGAAHGR--QVAVV--SATVTEE-IELVANRM-LHDPVRI 198
Cdd:COG0514 125 ellrrLKISLFAIDEahcisqwGHDF--RpDYRRL------GELRERlpNVPVLalTATATPRvRADIAEQLgLEDPRVF 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 199 KiaatevpasgkveHSF---------IKIEERDKTE-LLRKLSNLSGLRGL---AFINNLDQVMMKESKLGFRnapIVAL 265
Cdd:COG0514 197 V-------------GSFdrpnlrlevVPKPPDDKLAqLLDFLKEHPGGSGIvycLSRKKVEELAEWLREAGIR---AAAY 260
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1724454833 266 HSEMKKEERKSAIERFRKGDARVLLATdIA-ARGLDIEGLTHVIHVNVPFTKEQYIHRSGRTGRAGNSGEVLTL 338
Cdd:COG0514 261 HAGLDAEEREANQDRFLRDEVDVIVAT-IAfGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLL 333
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
246-338 |
5.06e-05 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 42.97 E-value: 5.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 246 DQVMMKESKLGFRNApivALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFTKEQYIHRSGR 325
Cdd:cd18794 44 EQVAARLQSKGISAA---AYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGR 120
|
90
....*....|...
gi 1724454833 326 TGRAGNSGEVLTL 338
Cdd:cd18794 121 AGRDGLPSECILF 133
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
42-164 |
5.86e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 42.68 E-value: 5.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 42 PTGTGKTLayllpILQKVDGAKKATQALIVAPSQELCMQIVEVIRTWiagTNITVVPLIGGanpqrqiEKLKKKPT--IV 119
Cdd:cd17926 26 PTGSGKTL-----TALALIAYLKELRTLIVVPTDALLDQWKERFEDF---LGDSSIGLIGG-------GKKKDFDDanVV 90
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1724454833 120 VGTPGRLNELITSKKLKLHEINMIVLDEGDQLLSRDYRVIVKGFI 164
Cdd:cd17926 91 VATYQSLSNLAEEEKDLFDQFGLLIVDEAHHLPAKTFSEILKELN 135
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
24-147 |
1.12e-04 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 42.27 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 24 QEQMVEAFLEG-----KDVVAESPTGTGKTLAYLLPI--LQKVDGAKKatqALIVAPSQELCMQIVEVIRTWIagtnITV 96
Cdd:pfam04851 8 QIEAIENLLESikngqKRGLIVMATGSGKTLTAAKLIarLFKKGPIKK---VLFLVPRKDLLEQALEEFKKFL----PNY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1724454833 97 VPLIGGANPQRQIEKLKKKPtIVVGTPGRLNELITSKKLKL--HEINMIVLDE 147
Cdd:pfam04851 81 VEIGEIISGDKKDESVDDNK-IVVTTIQSLYKALELASLELlpDFFDVIIIDE 132
|
|
| PRK08074 |
PRK08074 |
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated |
2-71 |
1.34e-04 |
|
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated
Pssm-ID: 236148 [Multi-domain] Cd Length: 928 Bit Score: 44.17 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 2 AFLDLLNEdlqqkwKFPSTMPI------QEQMV----EAFLEGKDVVAESPTGTGKTLAYLLP-ILQkvdgAKKATQALI 70
Cdd:PRK08074 240 AFLEKTEE------KLSLAMPKyekregQQEMMkevyTALRDSEHALIEAGTGTGKSLAYLLPaAYF----AKKKEEPVV 309
|
.
gi 1724454833 71 V 71
Cdd:PRK08074 310 I 310
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
260-355 |
1.63e-04 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 41.56 E-value: 1.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 260 APIVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDI-EGLTHVIHVNVPFTKEQYIHRSGRTGRAGNSGEVLTL 338
Cdd:cd18810 52 ARIAIAHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIpNANTIIIERADKFGLAQLYQLRGRVGRSKERAYAYFL 131
|
90 100
....*....|....*....|
gi 1724454833 339 LAHHE---EQAYlKRMRELE 355
Cdd:cd18810 132 YPDQKkltEDAL-KRLEAIQ 150
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
252-329 |
1.99e-04 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 43.68 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 252 ESKLGFRNAPIVALHSEMKKEERKSAIERFRKGDA--RVLLATDIAARGLDIEGLTHVIHVNVPFT---KEQyihrsgRT 326
Cdd:COG0553 566 EERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEapVFLISLKAGGEGLNLTAADHVIHYDLWWNpavEEQ------AI 639
|
...
gi 1724454833 327 GRA 329
Cdd:COG0553 640 DRA 642
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
24-147 |
2.23e-04 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 42.03 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 24 QEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKATQALIV--APSQELCMQIVEVIRTWIAGTNITVVPLIG 101
Cdd:cd17927 7 QLELAQPALKGKNTIICLPTGSGKTFVAVLICEHHLKKFPAGRKGKVVflANKVPLVEQQKEVFRKHFERPGYKVTGLSG 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1724454833 102 GANPQRQIEKLKKKPTIVVGTPGRL-NELITSKKLKLHEINMIVLDE 147
Cdd:cd17927 87 DTSENVSVEQIVESSDVIIVTPQILvNDLKSGTIVSLSDFSLLVFDE 133
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
24-147 |
4.42e-04 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 42.55 E-value: 4.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 24 QEQMVEAFLEGKD-VVAesPTGTGKTLAYLLPI---LQKVDGakkatQALIVAPSQELCMQIVEVIRTWIAGTNITVVPL 99
Cdd:PRK13766 20 QQLLAATALKKNTlVVL--PTGLGKTAIALLVIaerLHKKGG-----KVLILAPTKPLVEQHAEFFRKFLNIPEEKIVVF 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1724454833 100 IGGANPQRQiEKLKKKPTIVVGTPGRL-NELITsKKLKLHEINMIVLDE 147
Cdd:PRK13766 93 TGEVSPEKR-AELWEKAKVIVATPQVIeNDLIA-GRISLEDVSLLIFDE 139
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
17-147 |
4.51e-04 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 41.09 E-value: 4.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 17 FPSTMPIQEQMVEAFLEGKD-VVAESPTGTGKT----LAYLLPILQKVDGAkkatqALIVAPSQELCMQIVEVIRTWIA- 90
Cdd:cd18021 1 FKFFNPIQTQVFNSLYNTDDnVFVGAPTGSGKTvcaeLALLRHWRQNPKGR-----AVYIAPMQELVDARYKDWRAKFGp 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724454833 91 GTNITVVPLIGGANpqrQIEKLKKKPTIVVGTPGRLNELitSKKLK----LHEINMIVLDE 147
Cdd:cd18021 76 LLGKKVVKLTGETS---TDLKLLAKSDVILATPEQWDVL--SRRWKqrknVQSVELFIADE 131
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
11-73 |
5.60e-04 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 40.81 E-value: 5.60e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724454833 11 LQQKWKFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPILqkvdgAKKATqALIVAP 73
Cdd:cd18015 10 LKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPAL-----CSDGF-TLVVSP 66
|
|
| SF2_C_priA |
cd18804 |
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication ... |
257-336 |
5.98e-04 |
|
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication factor Y or primosomal protein N', is a 3'-->5' DNA helicase that acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. PriA is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350191 [Multi-domain] Cd Length: 238 Bit Score: 41.08 E-value: 5.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 257 FRNAPIVALHSEM--KKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVIHVNVPFT--------KE---QYIHR- 322
Cdd:cd18804 114 FPEARIARIDRDTtrKKGALEKLLDQFERGEIDILIGTQMIAKGLDFPNVTLVGILNADSGlnspdfraSErafQLLTQv 193
|
90
....*....|....
gi 1724454833 323 SGRTGRAGNSGEVL 336
Cdd:cd18804 194 SGRAGRGDKPGKVI 207
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
32-147 |
6.60e-04 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 40.66 E-value: 6.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 32 LEGKDVVAESPTGTGKTLAYLLPILQKVDGAKKatQALIVAPSQELCMQIVEVIRTWIAGTNITVVPLIGGANPQRQieK 111
Cdd:cd18026 31 LEGRNLVYSLPTSGGKTLVAEILMLKRLLERRK--KALFVLPYVSIVQEKVDALSPLFEELGFRVEGYAGNKGRSPP--K 106
|
90 100 110
....*....|....*....|....*....|....*...
gi 1724454833 112 LKKKPTIVVGTPGRLNELITS--KKLKLHEINMIVLDE 147
Cdd:cd18026 107 RRKSLSVAVCTIEKANSLVNSliEEGRLDELGLVVVDE 144
|
|
| DEAHc_XPD-like |
cd17915 |
DEAH-box helicase domain of XPD family DEAD-like helicases; The xeroderma pigmentosum group D ... |
34-160 |
6.68e-04 |
|
DEAH-box helicase domain of XPD family DEAD-like helicases; The xeroderma pigmentosum group D (XPD)-like family members are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350673 [Multi-domain] Cd Length: 138 Bit Score: 39.72 E-value: 6.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 34 GKDVVAESPTGTGKTLAYLLPILQkVDGAKKATQALIVAPSQELCMQIVEVIRTWIAGTNITVVPLIGganpqrqieklk 113
Cdd:cd17915 1 GGHVALESPTGSGKTLSLLCSALS-YQREFHKTKVLYCSRTHSQIEQIIRELRKLLEKRKIRALALSS------------ 67
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1724454833 114 KKPTIVVGTPGRLNELITSKK--LKLHEInMIVLDEGDQLlsrDYRVIV 160
Cdd:cd17915 68 RDADIVVLPYPYLLDARIREFigIDLREQ-VVIIDEAHNL---DERSVI 112
|
|
| dinG |
PRK11747 |
ATP-dependent DNA helicase DinG; Provisional |
37-54 |
8.73e-04 |
|
ATP-dependent DNA helicase DinG; Provisional
Pssm-ID: 236966 [Multi-domain] Cd Length: 697 Bit Score: 41.35 E-value: 8.73e-04
|
| ComFA |
COG4098 |
Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, ... |
257-357 |
1.17e-03 |
|
Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair];
Pssm-ID: 443274 [Multi-domain] Cd Length: 451 Bit Score: 41.01 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 257 FRNAPIVALHSEmkKEERKSAIERFRKGDARVLLATDIAARGLDIEGlthvIHVNV-----P-FTKEQYIHRSGRTGRAG 330
Cdd:COG4098 343 FPEERIAGVHAE--DPERKEKVQAFRDGEIPILVTTTILERGVTFPN----VDVAVlgadhPvFTEAALVQIAGRVGRSA 416
|
90 100
....*....|....*....|....*....
gi 1724454833 331 N--SGEVltLLAHHEEQAYLKRMRElEIE 357
Cdd:COG4098 417 DypTGEV--IFFHHGKTRAMKRAIR-EIK 442
|
|
| DEXDc2 |
smart00488 |
DEAD-like helicases superfamily; |
16-56 |
1.40e-03 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214693 [Multi-domain] Cd Length: 289 Bit Score: 40.44 E-value: 1.40e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1724454833 16 KFP-STMPIQEQ-MVEAF--LE-GKDVVAESPTGTGKTLAYLLPIL 56
Cdd:smart00488 4 YFPyEPYPIQYEfMEELKrvLDrGKIGILESPTGTGKTLSLLCLTL 49
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
4-56 |
1.81e-03 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 40.64 E-value: 1.81e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1724454833 4 LDLLnEDLQQKW---KFPSTMPIQEQMVEAFLEGKDVVAESPTGTGKTLAYLLPIL 56
Cdd:PRK13767 15 LDLL-RPYVREWfkeKFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAII 69
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
34-179 |
4.01e-03 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 38.04 E-value: 4.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 34 GKDVVAESPTGTGKTLAYLLPILQkvDGAKKATQALIVA-PSQELCMQIVEVIRTWI--AGTNITVVPLIGGANPQRQIE 110
Cdd:cd17930 1 PGLVILEAPTGSGKTEAALLWALK--LAARGGKRRIIYAlPTRATINQMYERIREILgrLDDEDKVLLLHSKAALELLES 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 111 KLKKKPT------------------IVVGTPGR-LNELITSKK--LKLHEI--NMIVLDEGdQLLSRDY-RVIVKGFIDG 166
Cdd:cd17930 79 DEEPDDDpveavdwalllkrswlapIVVTTIDQlLESLLKYKHfeRRLHGLanSVVVLDEV-QAYDPEYmALLLKALLEL 157
|
170
....*....|....
gi 1724454833 167 AAHGR-QVAVVSAT 179
Cdd:cd17930 158 LGELGgPVVLMTAT 171
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
23-80 |
5.27e-03 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 38.11 E-value: 5.27e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724454833 23 IQEQMVEAFLEG-KDVVAESPTGTGKT----LAYLLPILQKVDGAKKATQALIVAPSQELCMQ 80
Cdd:cd18023 5 IQSEVFPDLLYSdKNFVVSAPTGSGKTvlfeLAILRLLKERNPLPWGNRKVVYIAPIKALCSE 67
|
|
| PRK07246 |
PRK07246 |
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated |
1-83 |
8.27e-03 |
|
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated
Pssm-ID: 180905 [Multi-domain] Cd Length: 820 Bit Score: 38.51 E-value: 8.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 1 MAFLDLLNEDLQQKWKfpstmpiqeQMVEAFLEGKDV-VAESPTGTGKTLAYLLPILQKvdgaKKATQALIVAPSQELCM 79
Cdd:PRK07246 239 IALLGLEERPKQESFA---------KLVGEDFHDGPAsFIEAQTGIGKTYGYLLPLLAQ----SDQRQIIVSVPTKILQD 305
|
....
gi 1724454833 80 QIVE 83
Cdd:PRK07246 306 QIMA 309
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
262-338 |
8.36e-03 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 37.13 E-value: 8.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454833 262 IVALHSEMKKEERKSAIERFRKGDARVLLATDIAARGLDIEGLTHVI------------------HVNVPFTKEQYIHRS 323
Cdd:cd18791 77 VLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIdsglvkekvydprtglssLVTVWISKASAEQRA 156
|
90
....*....|....*
gi 1724454833 324 GRTGRAGnSGEVLTL 338
Cdd:cd18791 157 GRAGRTR-PGKCYRL 170
|
|
| |
