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Conserved domains on  [gi|1724454841|ref|WP_147197236|]
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cysteine synthase A [Rummeliibacillus stabekisii]

Protein Classification

PLP-dependent cysteine synthase family protein( domain architecture ID 10000483)

cysteine synthase family protein is a pyridoxal 5'-phosphate (PLP)-dependent enzyme similar to Helicobacter pylori cysteine synthase

CATH:  3.40.50.1100
Gene Ontology:  GO:0030170
SCOP:  4000798

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
1-302 1.21e-164

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


:

Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 459.51  E-value: 1.21e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   1 MNYYHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGL 80
Cdd:COG0031     1 MRIYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  81 AMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTA 160
Cdd:COG0031    80 AMVAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 161 VEILDTFDGSLDAFV-----------LtagtggtvtgtGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFV 229
Cdd:COG0031   160 PEIWEQTDGKVDAFVagvgtggtitgV-----------GRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFV 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724454841 230 PSILNRDIYDEILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLSS 302
Cdd:COG0031   229 PKILDPSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKRLGPGKTIVTILPDSGERYLST 301
 
Name Accession Description Interval E-value
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
1-302 1.21e-164

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 459.51  E-value: 1.21e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   1 MNYYHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGL 80
Cdd:COG0031     1 MRIYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  81 AMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTA 160
Cdd:COG0031    80 AMVAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 161 VEILDTFDGSLDAFV-----------LtagtggtvtgtGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFV 229
Cdd:COG0031   160 PEIWEQTDGKVDAFVagvgtggtitgV-----------GRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFV 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724454841 230 PSILNRDIYDEILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLSS 302
Cdd:COG0031   229 PKILDPSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKRLGPGKTIVTILPDSGERYLST 301
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
7-305 1.12e-148

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 419.08  E-value: 1.12e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEAtGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKsTIIEPTSGNTGIGLAMVCAV 86
Cdd:TIGR01139   1 ISELIGNTPLVRLNRIEGC-NANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGK-TIVEPTSGNTGIALAMVAAA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDS-FIPMQFDNQANADAHRKTTAVEILD 165
Cdd:TIGR01139  79 RGYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSyFMLQQFENPANPEIHRKTTGPEIWR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 166 TFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIE 245
Cdd:TIGR01139 159 DTDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVS 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 246 DEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLSSDLF 305
Cdd:TIGR01139 239 DEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPEPDKLIVVILPSTGERYLSTPLF 298
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
12-301 1.92e-147

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 415.76  E-value: 1.92e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  12 GKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMVCAVKGYPC 91
Cdd:cd01561     1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  92 IITMPDNATKERIKIMKAYGAEVHLTPSEFR--MQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDTFDG 169
Cdd:cd01561    80 IIVMPETMSEEKRKLLRALGAEVILTPEAEAdgMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 170 SLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIEDEDA 249
Cdd:cd01561   160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1724454841 250 TVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLS 301
Cdd:cd01561   240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLGPGKTIVTILPDSGERYLS 291
PRK10717 PRK10717
cysteine synthase A; Provisional
1-307 2.13e-94

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 282.52  E-value: 2.13e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   1 MNYYHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKsTIIEPTSGNTGIGL 80
Cdd:PRK10717    1 MKIFEDVSDTIGNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGG-TIVEGTAGNTGIGL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  81 AMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPS-EFR-----MQGSIDEAIRLSKDIPDSFI-PMQFDNQANAD 153
Cdd:PRK10717   80 ALVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVPAaPYAnpnnyVKGAGRLAEELVASEPNGAIwANQFDNPANRE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 154 AHRKTTAVEILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLS---GGQ---PGPHKIPGTGPG 227
Cdd:PRK10717  160 AHYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGSALYSyykTGElkaEGSSITEGIGQG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 228 FVPSILNRDIYDEILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLSSDLFED 307
Cdd:PRK10717  240 RITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLARELGPGHTIVTILCDSGERYQSKLFNPD 319
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
7-294 7.87e-77

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 236.44  E-value: 7.87e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGklipGKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:pfam00291   1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAAR 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRmqGSIDEAIRLSKDIPDSFIPMQFDNQANADAHrKTTAVEILDT 166
Cdd:pfam00291  77 LGLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGDYD--EAVAAARELAAEGPGAYYINQYDNPLNIEGY-GTIGLEILEQ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGG---------QPGPHKIPGTGPGFVPSILNRDI 237
Cdd:pfam00291 154 LGGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDL 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454841 238 Y----DEILHIEDEDATVMARRLAAEEGIFVGASGAAS-AFMAVQVAKKLPPNAKVLCIAPD 294
Cdd:pfam00291 234 LdeyvGEVVTVSDEEALEAMRLLARREGIVVEPSSAAAlAALKLALAGELKGGDRVVVVLTG 295
 
Name Accession Description Interval E-value
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
1-302 1.21e-164

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 459.51  E-value: 1.21e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   1 MNYYHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGL 80
Cdd:COG0031     1 MRIYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  81 AMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTA 160
Cdd:COG0031    80 AMVAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 161 VEILDTFDGSLDAFV-----------LtagtggtvtgtGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFV 229
Cdd:COG0031   160 PEIWEQTDGKVDAFVagvgtggtitgV-----------GRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFV 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724454841 230 PSILNRDIYDEILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLSS 302
Cdd:COG0031   229 PKILDPSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKRLGPGKTIVTILPDSGERYLST 301
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
7-305 1.12e-148

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 419.08  E-value: 1.12e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEAtGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKsTIIEPTSGNTGIGLAMVCAV 86
Cdd:TIGR01139   1 ISELIGNTPLVRLNRIEGC-NANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGK-TIVEPTSGNTGIALAMVAAA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDS-FIPMQFDNQANADAHRKTTAVEILD 165
Cdd:TIGR01139  79 RGYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSyFMLQQFENPANPEIHRKTTGPEIWR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 166 TFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIE 245
Cdd:TIGR01139 159 DTDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVS 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 246 DEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLSSDLF 305
Cdd:TIGR01139 239 DEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPEPDKLIVVILPSTGERYLSTPLF 298
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
12-301 1.92e-147

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 415.76  E-value: 1.92e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  12 GKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMVCAVKGYPC 91
Cdd:cd01561     1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  92 IITMPDNATKERIKIMKAYGAEVHLTPSEFR--MQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDTFDG 169
Cdd:cd01561    80 IIVMPETMSEEKRKLLRALGAEVILTPEAEAdgMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 170 SLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIEDEDA 249
Cdd:cd01561   160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1724454841 250 TVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLS 301
Cdd:cd01561   240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLGPGKTIVTILPDSGERYLS 291
cysKM TIGR01136
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ...
7-305 3.14e-142

cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273463  Cd Length: 299  Bit Score: 402.81  E-value: 3.14e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKsTIIEPTSGNTGIGLAMVCAV 86
Cdd:TIGR01136   1 IEELIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGD-TIIEATSGNTGIALAMVAAA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDT 166
Cdd:TIGR01136  80 RGYKLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETNKYVMLDQFENPANPEAHYKTTGPEIWRD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIED 246
Cdd:TIGR01136 160 TDGRIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPAESPVLSGGEPGPHKIQGIGAGFIPKILDLSLIDEVITVSD 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 247 EDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKL-PPNAKVLCIAPDTGERYLSSDLF 305
Cdd:TIGR01136 240 EDAIETARRLAREEGILVGISSGAAVAAALKLAKRLeNADKVIVAILPDTGERYLSTGLF 299
PRK10717 PRK10717
cysteine synthase A; Provisional
1-307 2.13e-94

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 282.52  E-value: 2.13e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   1 MNYYHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKsTIIEPTSGNTGIGL 80
Cdd:PRK10717    1 MKIFEDVSDTIGNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGG-TIVEGTAGNTGIGL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  81 AMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPS-EFR-----MQGSIDEAIRLSKDIPDSFI-PMQFDNQANAD 153
Cdd:PRK10717   80 ALVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVPAaPYAnpnnyVKGAGRLAEELVASEPNGAIwANQFDNPANRE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 154 AHRKTTAVEILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLS---GGQ---PGPHKIPGTGPG 227
Cdd:PRK10717  160 AHYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGSALYSyykTGElkaEGSSITEGIGQG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 228 FVPSILNRDIYDEILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLSSDLFED 307
Cdd:PRK10717  240 RITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLARELGPGHTIVTILCDSGERYQSKLFNPD 319
cysM PRK11761
cysteine synthase CysM;
4-307 7.08e-94

cysteine synthase CysM;


Pssm-ID: 236972  Cd Length: 296  Bit Score: 279.84  E-value: 7.08e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   4 YHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMV 83
Cdd:PRK11761    3 YPTLEDTIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPG-DTLIEATSGNTGIALAMI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  84 CAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDiPDSFIPMQFDNQANADAHRKTTAVEI 163
Cdd:PRK11761   82 AAIKGYRMKLIMPENMSQERRAAMRAYGAELILVPKEQGMEGARDLALQMQAE-GEGKVLDQFANPDNPLAHYETTGPEI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 164 LDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPA-GSPVlsggqPGPHKIPgtgPGFVPSILNRDIYDEIL 242
Cdd:PRK11761  161 WRQTEGRITHFVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQPEeGSSI-----PGIRRWP---EEYLPKIFDASRVDRVL 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1724454841 243 HIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLpPNAKVLCIAPDTGERYLSSDLFED 307
Cdd:PRK11761  233 DVSQQEAENTMRRLAREEGIFCGVSSGGAVAAALRIAREN-PNAVIVAIICDRGDRYLSTGVFPA 296
PLN02565 PLN02565
cysteine synthase
7-306 3.97e-93

cysteine synthase


Pssm-ID: 166206  Cd Length: 322  Bit Score: 279.12  E-value: 3.97e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PLN02565    9 VTELIGKTPLVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVLIEPTSGNTGIGLAFMAAA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDT 166
Cdd:PLN02565   89 KGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPNSYILQQFENPANPKIHYETTGPEIWKG 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIED 246
Cdd:PLN02565  169 TGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLSGGKPGPHKIQGIGAGFIPGVLDVDLLDEVVQVSS 248
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454841 247 EDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKlPPNAKVLCIA--PDTGERYLSSDLFE 306
Cdd:PLN02565  249 DEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKR-PENAGKLIVVifPSFGERYLSSVLFE 309
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
10-307 6.82e-91

cysteine synthase/L-3-cyanoalanine synthase


Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 274.92  E-value: 6.82e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  10 LVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKSTIIEPTSGNTGIGLAMVCAVKGY 89
Cdd:PLN02556   56 LIGKTPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGKTTLIEPTSGNMGISLAFMAAMKGY 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  90 PCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDTFDG 169
Cdd:PLN02556  136 KMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPEIWEDTLG 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 170 SLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIEDEDA 249
Cdd:PLN02556  216 QVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGKPGPHHITGNGVGFKPDILDMDVMEKVLEVSSEDA 295
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1724454841 250 TVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAK-VLCIAPDTGERYLSSDLFED 307
Cdd:PLN02556  296 VNMARELALKEGLMVGISSGANTVAALRLAKMPENKGKlIVTVHPSFGERYLSSVLFQE 354
PLN00011 PLN00011
cysteine synthase
7-306 7.38e-87

cysteine synthase


Pssm-ID: 177651  Cd Length: 323  Bit Score: 263.02  E-value: 7.38e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PLN00011   11 VTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNTGIGLACIGAA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDT 166
Cdd:PLN00011   91 RGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHYRTTGPEIWRD 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIED 246
Cdd:PLN00011  171 SAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLTIVDEIIQVTG 250
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454841 247 EDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKlPPNAK--VLCIAPDTGERYLSSDLFE 306
Cdd:PLN00011  251 EEAIETAKLLALKEGLLVGISSGAAAAAALKVAKR-PENAGklIVVIFPSGGERYLSTKLFE 311
cysta_beta TIGR01137
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ...
5-301 3.49e-86

cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273464 [Multi-domain]  Cd Length: 455  Bit Score: 265.51  E-value: 3.49e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   5 HSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMVC 84
Cdd:TIGR01137   3 DNILDLIGNTPLVRLNKVSKGLKCELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPG-DTIIEPTSGNTGIGLALVA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  85 AVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRM---QGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAV 161
Cdd:TIGR01137  82 AIKGYKCIIVLPEKMSSEKVDVLRALGAEIVRTPTAAAFdspESHIGVAKRLVREIPGAHILDQYRNPSNPLAHYDTTGP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 162 EILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSpVLSGGQP------GPHKIPGTGPGFVPSILNR 235
Cdd:TIGR01137 162 EILEQCEGKLDMFVAGVGTGGTITGIARYLKESCPGCRIVGADPEGS-ILAQPEElnqtgrTPYKVEGIGYDFIPTVLDR 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1724454841 236 DIYDEILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKK-LPPNAKVLCIAPDTGERYLS 301
Cdd:TIGR01137 241 KVVDEWIKTDDKESFTMARRLIKEEGLLVGGSSGSAVVAALKAAEDeLQEGQRCVVLLPDSIRNYMT 307
PLP_SbnA_fam TIGR03945
2,3-diaminopropionate biosynthesis protein SbnA; Members of this family include SbnA, a ...
7-302 1.55e-84

2,3-diaminopropionate biosynthesis protein SbnA; Members of this family include SbnA, a protein of the staphyloferrin B biosynthesis operon of Staphylococcus aureus. SbnA and SbnB together appear to synthesize 2,3-diaminopropionate, a precursor of certain siderophores and other secondary metabolites. SbnA is a pyridoxal phosphate-dependent enzyme. [Cellular processes, Biosynthesis of natural products]


Pssm-ID: 274872 [Multi-domain]  Cd Length: 304  Bit Score: 256.36  E-value: 1.55e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMVCAV 86
Cdd:TIGR03945   1 ILSLIGNTPLVKLERLFPDAPFRLFAKLEGFNPGGSIKDRPALYILEAAIKRGRITPG-TTIIESSSGNLGIALAMICAY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQG----SIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVE 162
Cdd:TIGR03945  80 KGLRFICVVDPNISPQNLKLLRAYGAEVEKVTEPDETGGylgtRIARVRELLASIPDAYWPNQYANPDNPRAHYHGTGRE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 163 ILDTFDgSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSpVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEIL 242
Cdd:TIGR03945 160 IARAFP-TLDYLFVGVSTTGTLMGCSRRLRERGPNTKVIAVDAVGS-VIFGGPPGRRHIPGLGASVVPELLDESLIDDVV 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724454841 243 HIEDEDATVMARRLAAEEGIFVGASgAASAFMAV-QVAKKLPPNAKVLCIAPDTGERYLSS 302
Cdd:TIGR03945 238 HVPEYDTVAGCRRLARREGILAGGS-SGTVVAAIkRLLPRIPEGSTVVAILPDRGERYLDT 297
cysM TIGR01138
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of ...
6-305 1.23e-83

cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of sulfide, to produce cysteine thiosulfonate instead of cysteine. Alternate name: O-acetylserine (thiol)-lyase [Amino acid biosynthesis, Serine family]


Pssm-ID: 130208 [Multi-domain]  Cd Length: 290  Bit Score: 253.68  E-value: 1.23e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   6 SILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKsTIIEPTSGNTGIGLAMVCA 85
Cdd:TIGR01138   1 TIEQTVGNTPLVRLQRMGPENGSEVWLKLEGNNPAGSVKDRPALSMIVEAEKRGEIKPGD-VLIEATSGNTGIALAMIAA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  86 VKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPmQFDNQANADAHRKTTAVEILD 165
Cdd:TIGR01138  80 LKGYRMKLLMPDNMSQERKAAMRAYGAELILVTKEEGMEGARDLALELANRGEGKLLD-QFNNPDNPYAHYTSTGPEIWQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 166 TFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPA-GSPVlsggqPGPHKIPGTgpgFVPSILNRDIYDEILHI 244
Cdd:TIGR01138 159 QTGGRITHFVSSMGTTGTIMGVSRFLKEQNPPVQIVGLQPEeGSSI-----PGIRRWPTE---YLPGIFDASLVDRVLDI 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724454841 245 EDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLpPNAKVLCIAPDTGERYLSSDLF 305
Cdd:TIGR01138 231 HQRDAENTMRELAVREGIFCGVSSGGAVAAALRLAREL-PDAVVVAIICDRGDRYLSTGVF 290
PLN03013 PLN03013
cysteine synthase
1-306 1.24e-77

cysteine synthase


Pssm-ID: 178587 [Multi-domain]  Cd Length: 429  Bit Score: 243.15  E-value: 1.24e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   1 MNYYHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKSTIIEPTSGNTGIGL 80
Cdd:PLN03013  111 LNIADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGL 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  81 AMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTA 160
Cdd:PLN03013  191 AFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYETTG 270
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 161 VEILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDE 240
Cdd:PLN03013  271 PEIWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDE 350
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1724454841 241 ILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKlPPNA-KVLCIAPDTGERYLSSDLFE 306
Cdd:PLN03013  351 VIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKR-PENAgKLIAVSLFASGRDIYTPRCS 416
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
7-294 7.87e-77

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 236.44  E-value: 7.87e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGklipGKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:pfam00291   1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAAR 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRmqGSIDEAIRLSKDIPDSFIPMQFDNQANADAHrKTTAVEILDT 166
Cdd:pfam00291  77 LGLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGDYD--EAVAAARELAAEGPGAYYINQYDNPLNIEGY-GTIGLEILEQ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGG---------QPGPHKIPGTGPGFVPSILNRDI 237
Cdd:pfam00291 154 LGGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDL 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454841 238 Y----DEILHIEDEDATVMARRLAAEEGIFVGASGAAS-AFMAVQVAKKLPPNAKVLCIAPD 294
Cdd:pfam00291 234 LdeyvGEVVTVSDEEALEAMRLLARREGIVVEPSSAAAlAALKLALAGELKGGDRVVVVLTG 295
Trp-synth-beta_II cd00640
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
14-294 1.80e-74

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


Pssm-ID: 107202 [Multi-domain]  Cd Length: 244  Bit Score: 228.55  E-value: 1.80e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  14 TPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLipGKSTIIEPTSGNTGIGLAMVCAVKGYPCII 93
Cdd:cd00640     1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKL--PKGVIIESTGGNTGIALAAAAARLGLKCTI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  94 TMPDNATKERIKIMKAYGAEVHLTPSEFrmQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHrKTTAVEILDTFDGS-LD 172
Cdd:cd00640    79 VMPEGASPEKVAQMRALGAEVVLVPGDF--DDAIALAKELAEEDPGAYYVNQFDNPANIAGQ-GTIGLEILEQLGGQkPD 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 173 AFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPagspvlsggqpgphkipgtgpgfvpsilnrdiydEILHIEDEDATVM 252
Cdd:cd00640   156 AVVVPVGGGGNIAGIARALKELLPNVKVIGVEP----------------------------------EVVTVSDEEALEA 201
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1724454841 253 ARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPD 294
Cdd:cd00640   202 IRLLAREEGILVEPSSAAALAAALKLAKKLGKGKTVVVILTG 243
PLN02356 PLN02356
phosphateglycerate kinase
7-301 3.23e-40

phosphateglycerate kinase


Pssm-ID: 215204  Cd Length: 423  Bit Score: 145.13  E-value: 3.23e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PLN02356   47 LIDAIGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPG-GVVTEGSAGSTAISLATVAPA 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVH---------------------LTPSEF----------------RMQGSIDE 129
Cdd:PLN02356  126 YGCKCHVVIPDDVAIEKSQILEALGATVErvrpvsithkdhyvniarrraLEANELaskrrkgsetdgihleKTNGCISE 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 130 AIR----LSKDIPDSFIPMQFDNQANADAHRKTTAVEILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEP 205
Cdd:PLN02356  206 EEKenslFSSSCTGGFFADQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQEKNPNIKCFLIDP 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 206 AGSPVLSGGQPG---------------PHKIPGTGPGFVPSILNRDI--YDEILHIEDEDATVMARRLAAEEGIFVGASG 268
Cdd:PLN02356  286 PGSGLFNKVTRGvmytreeaegrrlknPFDTITEGIGINRLTQNFLMakLDGAFRGTDKEAVEMSRYLLKNDGLFVGSSS 365
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1724454841 269 AASAFMAVQVAKKLPPNAKVLCIAPDTGERYLS 301
Cdd:PLN02356  366 AMNCVGAVRVAQSLGPGHTIVTILCDSGMRHLS 398
ThrC COG0498
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ...
11-303 2.33e-26

Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 440264 [Multi-domain]  Cd Length: 394  Bit Score: 107.21  E-value: 2.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  11 VGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLipgksTIIEPTSGNTGIGLAMVCAVKGYP 90
Cdd:COG0498    64 EGGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKDRAMQVAVSLALERGAK-----TIVCASSGNGSAALAAYAARAGIE 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  91 CIITMP-DNATKERIKIMKAYGAEVHLtpsefrMQGSIDEAIRLSKDIpdsfipmqFDNQANADAH-----R----KTTA 160
Cdd:COG0498   139 VFVFVPeGKVSPGQLAQMLTYGAHVIA------VDGNFDDAQRLVKEL--------AADEGLYAVNsinpaRlegqKTYA 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 161 VEILDTFDGSLDAFV---------------LtagtggtvtgtgEELKKQ-----LPdlKIYVVEPAG-SPVLSGGQPG-P 218
Cdd:COG0498   205 FEIAEQLGRVPDWVVvptgnggnilagykaF------------KELKELglidrLP--RLIAVQATGcNPILTAFETGrD 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 219 HKIPGTGPGFVPSILNRD------IYDEI-------LHIEDEDATVMARRLAAEEGIFVGASGAAsafmAVQVAKKL--- 282
Cdd:COG0498   271 EYEPERPETIAPSMDIGNpsngerALFALresggtaVAVSDEEILEAIRLLARREGIFVEPATAV----AVAGLRKLree 346
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1724454841 283 ---PPNAKVLCIA-------PDTGERYLSSD 303
Cdd:COG0498   347 geiDPDEPVVVLStghglkfPDAVREALGGE 377
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
7-291 3.25e-24

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 100.11  E-value: 3.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:COG1171    18 IAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASLSEEER----ARGVVAASAGNHAQGVAYAARL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFrmQGSIDEAIRLSKD-----IPDsfipmqFDN------QAnadah 155
Cdd:COG1171    94 LGIPATIVMPETAPAVKVAATRAYGAEVVLHGDTY--DDAEAAAAELAEEegatfVHP------FDDpdviagQG----- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 156 rkTTAVEILDTFD-----------GSLDAFVLTAgtggtvtgtgeeLKKQLPDLKIYVVEPAGSPV----LSGGQPGPHK 220
Cdd:COG1171   161 --TIALEILEQLPdldavfvpvggGGLIAGVAAA------------LKALSPDIRVIGVEPEGAAAmyrsLAAGEPVTLP 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 221 IPGTgpgFV-------PSILNRDIY----DEILHIEDEDATVMARRLAAEEGIFVGASGAAsAFMAVQVAKKLPPNAKVL 289
Cdd:COG1171   227 GVDT---IAdglavgrPGELTFEILrdlvDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAA-ALAALLAGKERLKGKRVV 302

                  ..
gi 1724454841 290 CI 291
Cdd:COG1171   303 VV 304
Thr-synth_1 cd01563
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ...
12-291 2.55e-22

Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.


Pssm-ID: 107206 [Multi-domain]  Cd Length: 324  Bit Score: 94.97  E-value: 2.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  12 GKTPIVKLNKIPEATGA-EVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgkSTIIEPTSGNTGIGLAMVCAVKGYP 90
Cdd:cd01563    21 GNTPLVRAPRLGERLGGkNLYVKDEGLNPTGSFKDRGMTVAVSKAKELGV-----KAVACASTGNTSASLAAYAARAGIK 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  91 CIITMPDNATKERIKIMKAYGAEVHltpsefRMQGSIDEAIRLSKDIPDSFIpmqFDNQANADAHR----KTTAVEILDT 166
Cdd:cd01563    96 CVVFLPAGKALGKLAQALAYGATVL------AVEGNFDDALRLVRELAEENW---IYLSNSLNPYRlegqKTIAFEIAEQ 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSL-DAFVL---TAGTGGTVTGTGEELKKQ-----LPdlKIYVVEPAG-SPVLSGGQPG-PHKIPGTGPGFVPS---I 232
Cdd:cd01563   167 LGWEVpDYVVVpvgNGGNITAIWKGFKELKELglidrLP--RMVGVQAEGaAPIVRAFKEGkDDIEPVENPETIATairI 244
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1724454841 233 LNRDIYDEILH-----------IEDEDATVMARRLAAEEGIFVGASGAASafmaVQVAKKL------PPNAKVLCI 291
Cdd:cd01563   245 GNPASGPKALRavresggtavaVSDEEILEAQKLLARTEGIFVEPASAAS----LAGLKKLreegiiDKGERVVVV 316
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
7-291 4.69e-22

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 93.71  E-value: 4.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:cd01562    11 IKPVVRRTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLSLSEEER----AKGVVAASAGNHAQGVAYAAKL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFrmQGSIDEAIRLSKDIPDSFIPmQFDN------QAnadahrkTTA 160
Cdd:cd01562    87 LGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDF--DEAEAKARELAEEEGLTFIH-PFDDpdviagQG-------TIG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 161 VEILDTFDGsLDA-FV------------LTagtggtvtgtgeeLKKQLPDLKIYVVEPAGSPVLS----GGQPGPHKIPG 223
Cdd:cd01562   157 LEILEQVPD-LDAvFVpvggggliagiaTA-------------VKALSPNTKVIGVEPEGAPAMAqslaAGKPVTLPEVD 222
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1724454841 224 T---G-----PGFVPSILNRDIYDEILHIEDEDATVMARRLAAEEGIFVGASGAAsAFMAVQVAKKLPPNAKVLCI 291
Cdd:cd01562   223 TiadGlavkrPGELTFEIIRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGAL-ALAALLSGKLDLKGKKVVVV 297
PRK06608 PRK06608
serine/threonine dehydratase;
4-173 6.38e-18

serine/threonine dehydratase;


Pssm-ID: 235842 [Multi-domain]  Cd Length: 338  Bit Score: 82.51  E-value: 6.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   4 YHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLiPGKstIIEPTSGNTGIGLAMV 83
Cdd:PRK06608   14 HNRIKQYLHLTPIVHSESLNEMLGHEIFFKVESLQKTGAFKVRGVLNHLLELKEQGKL-PDK--IVAYSTGNHGQAVAYA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  84 CAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSefrmQGSIDEAIRLSKDipDSFIPMQFDNQANADAHRKTTAVEI 163
Cdd:PRK06608   91 SKLFGIKTRIYLPLNTSKVKQQAALYYGGEVILTNT----RQEAEEKAKEDEE--QGFYYIHPSDSDSTIAGAGTLCYEA 164
                         170
                  ....*....|
gi 1724454841 164 LDTFDGSLDA 173
Cdd:PRK06608  165 LQQLGFSPDA 174
PRK06381 PRK06381
threonine synthase; Validated
12-137 4.50e-16

threonine synthase; Validated


Pssm-ID: 235789  Cd Length: 319  Bit Score: 77.05  E-value: 4.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  12 GKTPIVKLNKIPEATG-AEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgkSTIIEPTSGNTGIGLAMVCAVKGYP 90
Cdd:PRK06381   14 GGTPLLRARKLEEELGlRKIYLKFEGANPTGTQKDRIAEAHVRRAMRLGY-----SGITVGTCGNYGASIAYFARLYGLK 88
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1724454841  91 CIITMPDNATKERIKIMKAYGAEVHLTPsefrmqGSIDEAIRLSKDI 137
Cdd:PRK06381   89 AVIFIPRSYSNSRVKEMEKYGAEIIYVD------GKYEEAVERSRKF 129
PRK06815 PRK06815
threonine/serine dehydratase;
1-290 4.03e-14

threonine/serine dehydratase;


Pssm-ID: 180709 [Multi-domain]  Cd Length: 317  Bit Score: 71.65  E-value: 4.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   1 MNYYHSILDL-------VGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMItraekegKLIPG---KSTIIE 70
Cdd:PRK06815    1 NTLFDAILEAhqrlrpqVRVTPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKL-------RLLNEaqrQQGVIT 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  71 PTSGNTGIGLAMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEfrMQGSIDEAIRLSKDIPDSFIPMQFDNQA 150
Cdd:PRK06815   74 ASSGNHGQGVALAAKLAGIPVTVYAPEQASAIKLDAIRALGAEVRLYGGD--ALNAELAARRAAEQQGKVYISPYNDPQV 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 151 NADahRKTTAVEILDTFDGsLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPV------------------LS 212
Cdd:PRK06815  152 IAG--QGTIGMELVEQQPD-LDAVFVAVGGGGLISGIATYLKTLSPKTEIIGCWPANSPSlytsleageivevaeqptLS 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 213 GGQPGphkipGTGPGFVPSILNRDIYDE-ILHIEDEDATVMARRLAAEEGIFVGASGAASAFMaVQVAKKL--PPNAKVL 289
Cdd:PRK06815  229 DGTAG-----GVEPGAITFPLCQQLIDQkVLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAA-LKLAPRYqgKKVAVVL 302

                  .
gi 1724454841 290 C 290
Cdd:PRK06815  303 C 303
thrC TIGR00260
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ...
5-291 8.73e-13

threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 272986 [Multi-domain]  Cd Length: 327  Bit Score: 67.79  E-value: 8.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   5 HSILDLV-GKTPIVKLNKIPEATGA-EVFIKLESFNPGGSVKDRAALNMITRAeKEGklipGKSTIIEPTSGNTGIGLAM 82
Cdd:TIGR00260  13 KDLVDLGeGVTPLFRAPALAANVGIkNLYVKELGHNPTLSFKDRGMAVALTKA-LEL----GNDTVLCASTGNTGAAAAA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  83 VCAVKGYPCIITMPDNAT-KERIKIMKAYGAEVhltpseFRMQGSIDEAIRLSKDIPDSFIPMQFdNQANADAHR----K 157
Cdd:TIGR00260  88 YAGKAGLKVVVLYPAGKIsLGKLAQALGYNAEV------VAIDGNFDDAQRLVKQLFEDKPALGL-NSANSIPYRlegqK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 158 TTAVEILDTFDGSL-DAFVLTAGTG---GTVTGTGEELKK----QLPDlKIYVVEPAGSPV----LSGGQPGPHKIPGTg 225
Cdd:TIGR00260 161 TYAFEAVEQLGWEApDKVVVPVPNSgnfGAIWKGFKEKKMlgldSLPV-KRGIQAEGAADIvrafLEGGQWEPIETPET- 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 226 pgFVPS--ILN--------RDIYDEILHIED--EDATVMA-RRLAAEEGIFVGASGAASafmaVQVAKKL------PPNA 286
Cdd:TIGR00260 239 --LSTAmdIGNpanwpralEAFRRSNGYAEDlsDEEILEAiKLLAREEGYFVEPHSAVA----VAALLKLvekgtaDPAE 312

                  ....*
gi 1724454841 287 KVLCI 291
Cdd:TIGR00260 313 RVVCA 317
PRK05638 PRK05638
threonine synthase; Validated
12-137 2.67e-12

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 66.76  E-value: 2.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  12 GKTPIVKlNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAekegkLIPGKSTIIEPTSGNTGIGLAMVCAVKGYPC 91
Cdd:PRK05638   65 GGTPLIR-ARISEKLGENVYIKDETRNPTGSFRDRLATVAVSYG-----LPYAANGFIVASDGNAAASVAAYSARAGKEA 138
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1724454841  92 IITMPDNATKERIKIMKAYGAEVhltpseFRMQGSIDEAIRLSKDI 137
Cdd:PRK05638  139 FVVVPRKVDKGKLIQMIAFGAKI------IRYGESVDEAIEYAEEL 178
PRK08329 PRK08329
threonine synthase; Validated
14-136 4.31e-12

threonine synthase; Validated


Pssm-ID: 236244 [Multi-domain]  Cd Length: 347  Bit Score: 65.62  E-value: 4.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  14 TPIVKLNKipeatgaEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgkSTIIEPTSGNTGIGLAMVCAVKGYPCII 93
Cdd:PRK08329   65 TPTVKRSI-------KVYFKLDYLQPTGSFKDRGTYVTVAKLKEEGI-----NEVVIDSSGNAALSLALYSLSEGIKVHV 132
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1724454841  94 TMPDNATKERIKIMKAYGAEVHLTPSEfRMQGSiDEAIRLSKD 136
Cdd:PRK08329  133 FVSYNASKEKISLLSRLGAELHFVEGD-RMEVH-EEAVKFSKR 173
PRK07048 PRK07048
threo-3-hydroxy-L-aspartate ammonia-lyase;
7-206 3.43e-11

threo-3-hydroxy-L-aspartate ammonia-lyase;


Pssm-ID: 235918 [Multi-domain]  Cd Length: 321  Bit Score: 63.11  E-value: 3.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PRK07048   18 LAGVAHRTPVLTSRTADARTGAQVFFKCENFQRMGAFKFRGAYNALSQFSPEQR----RAGVVTFSSGNHAQAIALSARL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVhltpSEFRMQGSIDEAI--RLSKDIPDSFIPmQFDNqANADAHRKTTAVEIL 164
Cdd:PRK07048   94 LGIPATIVMPQDAPAAKVAATRGYGGEV----VTYDRYTEDREEIgrRLAEERGLTLIP-PYDH-PHVIAGQGTAAKELF 167
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1724454841 165 DTFdGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPA 206
Cdd:PRK07048  168 EEV-GPLDALFVCLGGGGLLSGCALAARALSPGCKVYGVEPE 208
PRK08638 PRK08638
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
5-121 3.74e-11

bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;


Pssm-ID: 236317 [Multi-domain]  Cd Length: 333  Bit Score: 62.83  E-value: 3.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   5 HSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMI---TRAEKEgklipgkSTIIEPTSGNTGIGLA 81
Cdd:PRK08638   19 QRLAGRIRKTPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAFNKLsslTDAEKR-------KGVVACSAGNHAQGVA 91
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1724454841  82 MVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEF 121
Cdd:PRK08638   92 LSCALLGIDGKVVMPKGAPKSKVAATCGYGAEVVLHGDNF 131
Trp-synth_B cd06446
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the ...
9-132 1.68e-10

Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to glyceraldehyde 3-phosphate and indole at the active site of the alpha subunit. In the beta reaction, indole undergoes a PLP-dependent reaction with L-serine to form L-tryptophan at the active site of the beta subunit. Members of this CD, Trp-synth_B, are found in all three major phylogenetic divisions.


Pssm-ID: 107207  Cd Length: 365  Bit Score: 61.01  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   9 DLVGK-TPIVKLNKIPEAT-GAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:cd06446    29 DYVGRpTPLYRAKRLSEYLgGAKIYLKREDLNHTGAHKINNALGQALLAKRMGK----KRVIAETGAGQHGVATATACAL 104
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITM--PDNATKE-RIKIMKAYGAEVHLTPSEFRMQG-SIDEAIR 132
Cdd:cd06446   105 FGLECEIYMgaVDVERQPlNVFRMELLGAEVVPVPSGSGTLKdAISEAIR 154
PRK08197 PRK08197
threonine synthase; Validated
4-299 2.12e-10

threonine synthase; Validated


Pssm-ID: 181283 [Multi-domain]  Cd Length: 394  Bit Score: 60.78  E-value: 2.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   4 YHSILDLV----------GKTPIVKLNKIPEATGA-EVFIKLESFNPGGSVKDRAALNMITRAeKEgkliPGKSTIIEPT 72
Cdd:PRK08197   60 YHELLPVRdpehivslgeGMTPLLPLPRLGKALGIgRLWVKDEGLNPTGSFKARGLAVGVSRA-KE----LGVKHLAMPT 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  73 SGNTGIGLAMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVhltpseFRMQGSIDEAIRLSKDipdsFIPMQ--FDNQA 150
Cdd:PRK08197  135 NGNAGAAWAAYAARAGIRATIFMPADAPEITRLECALAGAEL------YLVDGLISDAGKIVAE----AVAEYgwFDVST 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 151 NADAHR----KTTAVEIldtfdgsldafvltagtggtvtgtGEELKKQLPDLKIY------------------------- 201
Cdd:PRK08197  205 LKEPYRiegkKTMGLEL------------------------AEQLGWRLPDVILYptgggvgligiwkafdelealgwig 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 202 -------VVEPAG-SPVLSGGQ---------PGPHKIpgtGPGF-VPSIL-NRDIYDEI-------LHIEDEDATVMARR 255
Cdd:PRK08197  261 gkrprlvAVQAEGcAPIVKAWEegkeesefwEDAHTV---AFGIrVPKALgDFLVLDAVretggcaIAVSDDAILAAQRE 337
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1724454841 256 LAAEEGIFVGASGAAsAFMAVQVAKK---LPPNAKVLCIAPDTGERY 299
Cdd:PRK08197  338 LAREEGLFACPEGAA-TFAAARQLREsgwLKGDERVVLFNTGSGLKY 383
PRK06110 PRK06110
threonine dehydratase;
24-133 9.25e-10

threonine dehydratase;


Pssm-ID: 235699  Cd Length: 322  Bit Score: 58.47  E-value: 9.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  24 EATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkstIIEPTSGNTGIGLAMVCAVKGYPCIITMPDNATKER 103
Cdd:PRK06110   32 ERLGCEVWVKHENHTPTGAFKVRGGLVYFDRLARRGPRVRG---VISATRGNHGQSVAFAARRHGLAATIVVPHGNSVEK 108
                          90       100       110
                  ....*....|....*....|....*....|
gi 1724454841 104 IKIMKAYGAEVHLTPSEFrmQGSIDEAIRL 133
Cdd:PRK06110  109 NAAMRALGAELIEHGEDF--QAAREEAARL 136
PRK06450 PRK06450
threonine synthase; Validated
12-129 1.18e-09

threonine synthase; Validated


Pssm-ID: 180565 [Multi-domain]  Cd Length: 338  Bit Score: 58.59  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  12 GKTPIVKlnkipeatGAEVFIKLESFNPGGSVKDRAALNMITR-AEKegklipGKSTIIEPTSGNTGIGLAMVCAVKGYP 90
Cdd:PRK06450   57 GRTPLIK--------KGNIWFKLDFLNPTGSYKDRGSVTLISYlAEK------GIKQISEDSSGNAGASIAAYGAAAGIE 122
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1724454841  91 CIITMPDNATKERIKIMKAYGAEVhltpseFRMQGSIDE 129
Cdd:PRK06450  123 VKIFVPETASGGKLKQIESYGAEV------VRVRGSRED 155
L-Ser-dehyd cd06448
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ...
13-148 4.23e-09

Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.


Pssm-ID: 107209  Cd Length: 316  Bit Score: 56.54  E-value: 4.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  13 KTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKliPGKSTIIEPTSGNTGIGLAMVCAVKGYPCI 92
Cdd:cd06448     1 KTPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGL--NECVHVVCSSGGNAGLAAAYAARKLGVPCT 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1724454841  93 ITMPdNATKER-IKIMKAYGAEVHLtpsefrmQGSI----DEAIRL---SKDIPDSFIPmQFDN 148
Cdd:cd06448    79 IVVP-ESTKPRvVEKLRDEGATVVV-------HGKVwweaDNYLREelaENDPGPVYVH-PFDD 133
PLN02970 PLN02970
serine racemase
7-208 8.20e-09

serine racemase


Pssm-ID: 215524 [Multi-domain]  Cd Length: 328  Bit Score: 55.84  E-value: 8.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEgkliPGKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PLN02970   21 IAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDD----QAEKGVVTHSSGNHAAALALAAKL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLtpSEFRMQGSIDEAIRLSKDIPDSFIPMQfdNQANADAHRKTTAVEILDT 166
Cdd:PLN02970   97 RGIPAYIVVPKNAPACKVDAVIRYGGIITW--CEPTVESREAVAARVQQETGAVLIHPY--NDGRVISGQGTIALEFLEQ 172
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1724454841 167 FDGsLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGS 208
Cdd:PLN02970  173 VPE-LDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGA 213
PRK12483 PRK12483
threonine dehydratase; Reviewed
7-208 1.03e-08

threonine dehydratase; Reviewed


Pssm-ID: 237111 [Multi-domain]  Cd Length: 521  Bit Score: 55.96  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PRK12483   31 VYDVARETPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGAYNKMARLPAEQL----ARGVITASAGNHAQGVALAAAR 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFrmQGSIDEAIRLSKDIPDSFIPmQFDNqANADAHRKTTAVEILDT 166
Cdd:PRK12483  107 LGVKAVIVMPRTTPQLKVDGVRAHGGEVVLHGESF--PDALAHALKLAEEEGLTFVP-PFDD-PDVIAGQGTVAMEILRQ 182
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGS 208
Cdd:PRK12483  183 HPGPLDAIFVPVGGGGLIAGIAAYVKYVRPEIKVIGVEPDDS 224
PRK08246 PRK08246
serine/threonine dehydratase;
13-122 1.40e-07

serine/threonine dehydratase;


Pssm-ID: 181319 [Multi-domain]  Cd Length: 310  Bit Score: 51.88  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  13 KTPIVKLNkIPEATGAEVFIKLESFNPGGSVKDRAALN-MITRAEKEgklipgkSTIIEPTSGNTGIGLAMVCAVKGYPC 91
Cdd:PRK08246   23 RTPVLEAD-GAGFGPAPVWLKLEHLQHTGSFKARGAFNrLLAAPVPA-------AGVVAASGGNAGLAVAYAAAALGVPA 94
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1724454841  92 IITMPDNATKERIKIMKAYGAEVHLTPSEFR 122
Cdd:PRK08246   95 TVFVPETAPPAKVARLRALGAEVVVVGAEYA 125
eutB PRK07476
threonine dehydratase; Provisional
7-165 1.79e-07

threonine dehydratase; Provisional


Pssm-ID: 236025 [Multi-domain]  Cd Length: 322  Bit Score: 51.89  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PRK07476   13 IAGRVRRTPLVASASLSARAGVPVWLKLETLQPTGSFKLRGATNALLSLSAQER----ARGVVTASTGNHGRALAYAARA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  87 KGYPCIITM----PDNATKErikiMKAYGAEVHLTPSefrmqgSIDEA----IRLSKDIPDSFIPmQFDNQAnADAHRKT 158
Cdd:PRK07476   89 LGIRATICMsrlvPANKVDA----IRALGAEVRIVGR------SQDDAqaevERLVREEGLTMVP-PFDDPR-IIAGQGT 156

                  ....*..
gi 1724454841 159 TAVEILD 165
Cdd:PRK07476  157 IGLEILE 163
PRK08206 PRK08206
diaminopropionate ammonia-lyase; Provisional
13-133 1.93e-07

diaminopropionate ammonia-lyase; Provisional


Pssm-ID: 236186  Cd Length: 399  Bit Score: 51.80  E-value: 1.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  13 KTPIVKLNKIPEATG-AEVFIKLESFNPG-GSVK------------------DRAALNMITRAEKEGKLIPGKSTIIEPT 72
Cdd:PRK08206   44 PTPLVALPDLAAELGvGSILVKDESYRFGlNAFKalggayavarllaeklglDISELSFEELTSGEVREKLGDITFATAT 123
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724454841  73 SGNTGIGLAMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHltpsefRMQGSIDEAIRL 133
Cdd:PRK08206  124 DGNHGRGVAWAAQQLGQKAVIYMPKGSSEERVDAIRALGAECI------ITDGNYDDSVRL 178
PLN02550 PLN02550
threonine dehydratase
1-206 3.15e-07

threonine dehydratase


Pssm-ID: 178165 [Multi-domain]  Cd Length: 591  Bit Score: 51.46  E-value: 3.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   1 MNYYHSIL-----DLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEgKLIPGkstIIEPTSGN 75
Cdd:PLN02550   92 MEYLTNILsakvyDVAIESPLQLAKKLSERLGVKVLLKREDLQPVFSFKLRGAYNMMAKLPKE-QLDKG---VICSSAGN 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  76 TGIGLAMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLtpsefrMQGSIDE----AIRLSKDIPDSFIPmQFDNqAN 151
Cdd:PLN02550  168 HAQGVALSAQRLGCDAVIAMPVTTPEIKWQSVERLGATVVL------VGDSYDEaqayAKQRALEEGRTFIP-PFDH-PD 239
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1724454841 152 ADAHRKTTAVEILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPA 206
Cdd:PLN02550  240 VIAGQGTVGMEIVRQHQGPLHAIFVPVGGGGLIAGIAAYVKRVRPEVKIIGVEPS 294
PRK13803 PRK13803
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional
4-132 4.51e-07

bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 237513 [Multi-domain]  Cd Length: 610  Bit Score: 50.97  E-value: 4.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841   4 YHSIL-DLVGK-TPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLA 81
Cdd:PRK13803  260 FKRLLqNYAGRpTPLTEAKRLSDIYGARIYLKREDLNHTGSHKINNALGQALLAKRMGK----TRIIAETGAGQHGVATA 335
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1724454841  82 MVCAVKGYPCIITMPDNATKERIK---IMKAYGAEVHLTPSEFR-MQGSIDEAIR 132
Cdd:PRK13803  336 TACALFGLKCTIFMGEEDIKRQALnveRMKLLGANVIPVLSGSKtLKDAVNEAIR 390
PLN02569 PLN02569
threonine synthase
29-168 2.35e-06

threonine synthase


Pssm-ID: 178182 [Multi-domain]  Cd Length: 484  Bit Score: 48.66  E-value: 2.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  29 EVFIKLESFNPGGSVKDR---AALNMITRAEKEGKLIPGKSTiiePTSGNTGIGLAMVCAVKGYPCIITMP-DNATKERI 104
Cdd:PLN02569  151 DLWVKHCGISHTGSFKDLgmtVLVSQVNRLRKMAKPVVGVGC---ASTGDTSAALSAYCAAAGIPSIVFLPaDKISIAQL 227
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1724454841 105 KIMKAYGAEVhltpseFRMQGSIDEAIRLSKDIpDSFIPMQFDNQANA--DAHRKTTAVEILDTFD 168
Cdd:PLN02569  228 VQPIANGALV------LSIDTDFDGCMRLIREV-TAELPIYLANSLNSlrLEGQKTAAIEILQQFD 286
PLN02618 PLN02618
tryptophan synthase, beta chain
21-132 8.34e-06

tryptophan synthase, beta chain


Pssm-ID: 215333  Cd Length: 410  Bit Score: 47.06  E-value: 8.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  21 KIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAVKGYPCIITMpDNAT 100
Cdd:PLN02618   80 KRADGEGPEIYLKREDLNHTGAHKINNAVAQALLAKRLGK----KRIIAETGAGQHGVATATVCARFGLECIVYM-GAQD 154
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1724454841 101 KERIKI----MKAYGAEVHLTPS-EFRMQGSIDEAIR 132
Cdd:PLN02618  155 MERQALnvfrMRLLGAEVRPVHSgTATLKDATSEAIR 191
PRK07334 PRK07334
threonine dehydratase; Provisional
11-116 1.69e-05

threonine dehydratase; Provisional


Pssm-ID: 235994 [Multi-domain]  Cd Length: 403  Bit Score: 46.04  E-value: 1.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  11 VGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALN---MITRAEKEgklipgkSTIIEPTSGNTGIGLAMVCAVK 87
Cdd:PRK07334   21 VLRTPCVHSRTLSQITGAEVWLKFENLQFTASFKERGALNkllLLTEEERA-------RGVIAMSAGNHAQGVAYHAQRL 93
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1724454841  88 GYPCIITMPdnATKERIKIM--KAYGAEVHL 116
Cdd:PRK07334   94 GIPATIVMP--RFTPTVKVErtRGFGAEVVL 122
PRK09224 PRK09224
threonine ammonia-lyase IlvA;
13-211 5.76e-05

threonine ammonia-lyase IlvA;


Pssm-ID: 236417 [Multi-domain]  Cd Length: 504  Bit Score: 44.36  E-value: 5.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  13 KTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAVKGYPCI 92
Cdd:PRK09224   20 ETPLEKAPKLSARLGNQVLLKREDLQPVFSFKLRGAYNKMAQLTEEQL----ARGVITASAGNHAQGVALSAARLGIKAV 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  93 ITMPdnATKERIKI--MKAYGAEVHLTPSEFrmqgsiDEA----IRLSKDIPDSFIPmQFDNQAnADAHRKTTAVEILDT 166
Cdd:PRK09224   96 IVMP--VTTPDIKVdaVRAFGGEVVLHGDSF------DEAyahaIELAEEEGLTFIH-PFDDPD-VIAGQGTIAMEILQQ 165
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1724454841 167 FDGSLDA-FV------LTAGTGGtvtgtgeeLKKQL-PDLKIYVVEPAGSPVL 211
Cdd:PRK09224  166 HPHPLDAvFVpvggggLIAGVAA--------YIKQLrPEIKVIGVEPEDSACL 210
PRK08813 PRK08813
threonine dehydratase; Provisional
30-139 6.06e-05

threonine dehydratase; Provisional


Pssm-ID: 236339 [Multi-domain]  Cd Length: 349  Bit Score: 44.23  E-value: 6.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  30 VFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPgkstIIEPTSGNTGIGLAMVCAVKGYPCIITMPDNATKERIKIMKA 109
Cdd:PRK08813   50 VWLKLENLQRTGSYKVRGALNALLAGLERGDERP----VICASAGNHAQGVAWSAYRLGVQAITVMPHGAPQTKIAGVAH 125
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1724454841 110 YGAEVhltpsefRMQG-SIDEAIRLSKDIPD 139
Cdd:PRK08813  126 WGATV-------RQHGnSYDEAYAFARELAD 149
PRK13028 PRK13028
tryptophan synthase subunit beta; Provisional
14-141 7.97e-04

tryptophan synthase subunit beta; Provisional


Pssm-ID: 183851  Cd Length: 402  Bit Score: 40.62  E-value: 7.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  14 TPIVKLNKIPEA-TGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAVKGYPCI 92
Cdd:PRK13028   63 TPLYHAKRLSEElGGAQIYLKREDLNHTGAHKINNCLGQALLAKRMGK----KRLIAETGAGQHGVATATAAALFGLECE 138
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1724454841  93 ITM-PDNATKE-----RIKIMkayGAEVH-LTPSEFRMQGSIDEAIR-LSKDIPDSF 141
Cdd:PRK13028  139 IYMgEVDIERQhpnvfRMKLL---GAEVVpVTRGGRTLKEAVDSAFEdYLKDPDNTH 192
PRK12391 PRK12391
TrpB-like pyridoxal phosphate-dependent enzyme;
14-121 3.02e-03

TrpB-like pyridoxal phosphate-dependent enzyme;


Pssm-ID: 237087  Cd Length: 427  Bit Score: 39.01  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841  14 TPIVKLNKIPEA--TGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGklipgkstiIEPTSGNTGIG-----LAMVCAV 86
Cdd:PRK12391   78 TPLIRARRLEKAlgTPAKIYYKYEGVSPTGSHKPNTAVAQAYYNKKEG---------IKRLTTETGAGqwgsaLALACAL 148
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1724454841  87 KGYPCIITMPD---NATKERIKIMKAYGAEVHLTPSEF 121
Cdd:PRK12391  149 FGLECTVFMVRvsyEQKPYRRSLMETYGAEVIPSPSDL 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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