|
Name |
Accession |
Description |
Interval |
E-value |
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
1-302 |
1.21e-164 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 459.51 E-value: 1.21e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 1 MNYYHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGL 80
Cdd:COG0031 1 MRIYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 81 AMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTA 160
Cdd:COG0031 80 AMVAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 161 VEILDTFDGSLDAFV-----------LtagtggtvtgtGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFV 229
Cdd:COG0031 160 PEIWEQTDGKVDAFVagvgtggtitgV-----------GRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFV 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724454841 230 PSILNRDIYDEILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLSS 302
Cdd:COG0031 229 PKILDPSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKRLGPGKTIVTILPDSGERYLST 301
|
|
| cysK |
TIGR01139 |
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ... |
7-305 |
1.12e-148 |
|
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273465 Cd Length: 298 Bit Score: 419.08 E-value: 1.12e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEAtGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKsTIIEPTSGNTGIGLAMVCAV 86
Cdd:TIGR01139 1 ISELIGNTPLVRLNRIEGC-NANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGK-TIVEPTSGNTGIALAMVAAA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDS-FIPMQFDNQANADAHRKTTAVEILD 165
Cdd:TIGR01139 79 RGYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSyFMLQQFENPANPEIHRKTTGPEIWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 166 TFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIE 245
Cdd:TIGR01139 159 DTDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVS 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 246 DEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLSSDLF 305
Cdd:TIGR01139 239 DEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPEPDKLIVVILPSTGERYLSTPLF 298
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
12-301 |
1.92e-147 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 415.76 E-value: 1.92e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 12 GKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMVCAVKGYPC 91
Cdd:cd01561 1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 92 IITMPDNATKERIKIMKAYGAEVHLTPSEFR--MQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDTFDG 169
Cdd:cd01561 80 IIVMPETMSEEKRKLLRALGAEVILTPEAEAdgMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 170 SLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIEDEDA 249
Cdd:cd01561 160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1724454841 250 TVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLS 301
Cdd:cd01561 240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLGPGKTIVTILPDSGERYLS 291
|
|
| cysKM |
TIGR01136 |
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ... |
7-305 |
3.14e-142 |
|
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273463 Cd Length: 299 Bit Score: 402.81 E-value: 3.14e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKsTIIEPTSGNTGIGLAMVCAV 86
Cdd:TIGR01136 1 IEELIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGD-TIIEATSGNTGIALAMVAAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDT 166
Cdd:TIGR01136 80 RGYKLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETNKYVMLDQFENPANPEAHYKTTGPEIWRD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIED 246
Cdd:TIGR01136 160 TDGRIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPAESPVLSGGEPGPHKIQGIGAGFIPKILDLSLIDEVITVSD 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 247 EDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKL-PPNAKVLCIAPDTGERYLSSDLF 305
Cdd:TIGR01136 240 EDAIETARRLAREEGILVGISSGAAVAAALKLAKRLeNADKVIVAILPDTGERYLSTGLF 299
|
|
| PRK10717 |
PRK10717 |
cysteine synthase A; Provisional |
1-307 |
2.13e-94 |
|
cysteine synthase A; Provisional
Pssm-ID: 182672 [Multi-domain] Cd Length: 330 Bit Score: 282.52 E-value: 2.13e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 1 MNYYHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKsTIIEPTSGNTGIGL 80
Cdd:PRK10717 1 MKIFEDVSDTIGNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGG-TIVEGTAGNTGIGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 81 AMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPS-EFR-----MQGSIDEAIRLSKDIPDSFI-PMQFDNQANAD 153
Cdd:PRK10717 80 ALVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVPAaPYAnpnnyVKGAGRLAEELVASEPNGAIwANQFDNPANRE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 154 AHRKTTAVEILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLS---GGQ---PGPHKIPGTGPG 227
Cdd:PRK10717 160 AHYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGSALYSyykTGElkaEGSSITEGIGQG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 228 FVPSILNRDIYDEILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPDTGERYLSSDLFED 307
Cdd:PRK10717 240 RITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLARELGPGHTIVTILCDSGERYQSKLFNPD 319
|
|
| cysM |
PRK11761 |
cysteine synthase CysM; |
4-307 |
7.08e-94 |
|
cysteine synthase CysM;
Pssm-ID: 236972 Cd Length: 296 Bit Score: 279.84 E-value: 7.08e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 4 YHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMV 83
Cdd:PRK11761 3 YPTLEDTIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPG-DTLIEATSGNTGIALAMI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 84 CAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDiPDSFIPMQFDNQANADAHRKTTAVEI 163
Cdd:PRK11761 82 AAIKGYRMKLIMPENMSQERRAAMRAYGAELILVPKEQGMEGARDLALQMQAE-GEGKVLDQFANPDNPLAHYETTGPEI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 164 LDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPA-GSPVlsggqPGPHKIPgtgPGFVPSILNRDIYDEIL 242
Cdd:PRK11761 161 WRQTEGRITHFVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQPEeGSSI-----PGIRRWP---EEYLPKIFDASRVDRVL 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1724454841 243 HIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLpPNAKVLCIAPDTGERYLSSDLFED 307
Cdd:PRK11761 233 DVSQQEAENTMRRLAREEGIFCGVSSGGAVAAALRIAREN-PNAVIVAIICDRGDRYLSTGVFPA 296
|
|
| PLN02565 |
PLN02565 |
cysteine synthase |
7-306 |
3.97e-93 |
|
cysteine synthase
Pssm-ID: 166206 Cd Length: 322 Bit Score: 279.12 E-value: 3.97e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PLN02565 9 VTELIGKTPLVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVLIEPTSGNTGIGLAFMAAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDT 166
Cdd:PLN02565 89 KGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPNSYILQQFENPANPKIHYETTGPEIWKG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIED 246
Cdd:PLN02565 169 TGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLSGGKPGPHKIQGIGAGFIPGVLDVDLLDEVVQVSS 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454841 247 EDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKlPPNAKVLCIA--PDTGERYLSSDLFE 306
Cdd:PLN02565 249 DEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKR-PENAGKLIVVifPSFGERYLSSVLFE 309
|
|
| PLN02556 |
PLN02556 |
cysteine synthase/L-3-cyanoalanine synthase |
10-307 |
6.82e-91 |
|
cysteine synthase/L-3-cyanoalanine synthase
Pssm-ID: 178171 [Multi-domain] Cd Length: 368 Bit Score: 274.92 E-value: 6.82e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 10 LVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKSTIIEPTSGNTGIGLAMVCAVKGY 89
Cdd:PLN02556 56 LIGKTPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGKTTLIEPTSGNMGISLAFMAAMKGY 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 90 PCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDTFDG 169
Cdd:PLN02556 136 KMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPEIWEDTLG 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 170 SLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIEDEDA 249
Cdd:PLN02556 216 QVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGKPGPHHITGNGVGFKPDILDMDVMEKVLEVSSEDA 295
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1724454841 250 TVMARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAK-VLCIAPDTGERYLSSDLFED 307
Cdd:PLN02556 296 VNMARELALKEGLMVGISSGANTVAALRLAKMPENKGKlIVTVHPSFGERYLSSVLFQE 354
|
|
| PLN00011 |
PLN00011 |
cysteine synthase |
7-306 |
7.38e-87 |
|
cysteine synthase
Pssm-ID: 177651 Cd Length: 323 Bit Score: 263.02 E-value: 7.38e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PLN00011 11 VTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNTGIGLACIGAA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVEILDT 166
Cdd:PLN00011 91 RGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHYRTTGPEIWRD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEILHIED 246
Cdd:PLN00011 171 SAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLTIVDEIIQVTG 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454841 247 EDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKlPPNAK--VLCIAPDTGERYLSSDLFE 306
Cdd:PLN00011 251 EEAIETAKLLALKEGLLVGISSGAAAAAALKVAKR-PENAGklIVVIFPSGGERYLSTKLFE 311
|
|
| cysta_beta |
TIGR01137 |
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ... |
5-301 |
3.49e-86 |
|
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273464 [Multi-domain] Cd Length: 455 Bit Score: 265.51 E-value: 3.49e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 5 HSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMVC 84
Cdd:TIGR01137 3 DNILDLIGNTPLVRLNKVSKGLKCELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPG-DTIIEPTSGNTGIGLALVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 85 AVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRM---QGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAV 161
Cdd:TIGR01137 82 AIKGYKCIIVLPEKMSSEKVDVLRALGAEIVRTPTAAAFdspESHIGVAKRLVREIPGAHILDQYRNPSNPLAHYDTTGP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 162 EILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSpVLSGGQP------GPHKIPGTGPGFVPSILNR 235
Cdd:TIGR01137 162 EILEQCEGKLDMFVAGVGTGGTITGIARYLKESCPGCRIVGADPEGS-ILAQPEElnqtgrTPYKVEGIGYDFIPTVLDR 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1724454841 236 DIYDEILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKK-LPPNAKVLCIAPDTGERYLS 301
Cdd:TIGR01137 241 KVVDEWIKTDDKESFTMARRLIKEEGLLVGGSSGSAVVAALKAAEDeLQEGQRCVVLLPDSIRNYMT 307
|
|
| PLP_SbnA_fam |
TIGR03945 |
2,3-diaminopropionate biosynthesis protein SbnA; Members of this family include SbnA, a ... |
7-302 |
1.55e-84 |
|
2,3-diaminopropionate biosynthesis protein SbnA; Members of this family include SbnA, a protein of the staphyloferrin B biosynthesis operon of Staphylococcus aureus. SbnA and SbnB together appear to synthesize 2,3-diaminopropionate, a precursor of certain siderophores and other secondary metabolites. SbnA is a pyridoxal phosphate-dependent enzyme. [Cellular processes, Biosynthesis of natural products]
Pssm-ID: 274872 [Multi-domain] Cd Length: 304 Bit Score: 256.36 E-value: 1.55e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMVCAV 86
Cdd:TIGR03945 1 ILSLIGNTPLVKLERLFPDAPFRLFAKLEGFNPGGSIKDRPALYILEAAIKRGRITPG-TTIIESSSGNLGIALAMICAY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQG----SIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTAVE 162
Cdd:TIGR03945 80 KGLRFICVVDPNISPQNLKLLRAYGAEVEKVTEPDETGGylgtRIARVRELLASIPDAYWPNQYANPDNPRAHYHGTGRE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 163 ILDTFDgSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSpVLSGGQPGPHKIPGTGPGFVPSILNRDIYDEIL 242
Cdd:TIGR03945 160 IARAFP-TLDYLFVGVSTTGTLMGCSRRLRERGPNTKVIAVDAVGS-VIFGGPPGRRHIPGLGASVVPELLDESLIDDVV 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724454841 243 HIEDEDATVMARRLAAEEGIFVGASgAASAFMAV-QVAKKLPPNAKVLCIAPDTGERYLSS 302
Cdd:TIGR03945 238 HVPEYDTVAGCRRLARREGILAGGS-SGTVVAAIkRLLPRIPEGSTVVAILPDRGERYLDT 297
|
|
| cysM |
TIGR01138 |
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of ... |
6-305 |
1.23e-83 |
|
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of sulfide, to produce cysteine thiosulfonate instead of cysteine. Alternate name: O-acetylserine (thiol)-lyase [Amino acid biosynthesis, Serine family]
Pssm-ID: 130208 [Multi-domain] Cd Length: 290 Bit Score: 253.68 E-value: 1.23e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 6 SILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKsTIIEPTSGNTGIGLAMVCA 85
Cdd:TIGR01138 1 TIEQTVGNTPLVRLQRMGPENGSEVWLKLEGNNPAGSVKDRPALSMIVEAEKRGEIKPGD-VLIEATSGNTGIALAMIAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 86 VKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPmQFDNQANADAHRKTTAVEILD 165
Cdd:TIGR01138 80 LKGYRMKLLMPDNMSQERKAAMRAYGAELILVTKEEGMEGARDLALELANRGEGKLLD-QFNNPDNPYAHYTSTGPEIWQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 166 TFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPA-GSPVlsggqPGPHKIPGTgpgFVPSILNRDIYDEILHI 244
Cdd:TIGR01138 159 QTGGRITHFVSSMGTTGTIMGVSRFLKEQNPPVQIVGLQPEeGSSI-----PGIRRWPTE---YLPGIFDASLVDRVLDI 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724454841 245 EDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKLpPNAKVLCIAPDTGERYLSSDLF 305
Cdd:TIGR01138 231 HQRDAENTMRELAVREGIFCGVSSGGAVAAALRLAREL-PDAVVVAIICDRGDRYLSTGVF 290
|
|
| PLN03013 |
PLN03013 |
cysteine synthase |
1-306 |
1.24e-77 |
|
cysteine synthase
Pssm-ID: 178587 [Multi-domain] Cd Length: 429 Bit Score: 243.15 E-value: 1.24e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 1 MNYYHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGKSTIIEPTSGNTGIGL 80
Cdd:PLN03013 111 LNIADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGL 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 81 AMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRMQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHRKTTA 160
Cdd:PLN03013 191 AFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYETTG 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 161 VEILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGGQPGPHKIPGTGPGFVPSILNRDIYDE 240
Cdd:PLN03013 271 PEIWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDE 350
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1724454841 241 ILHIEDEDATVMARRLAAEEGIFVGASGAASAFMAVQVAKKlPPNA-KVLCIAPDTGERYLSSDLFE 306
Cdd:PLN03013 351 VIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKR-PENAgKLIAVSLFASGRDIYTPRCS 416
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
7-294 |
7.87e-77 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 236.44 E-value: 7.87e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGklipGKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAAR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFRmqGSIDEAIRLSKDIPDSFIPMQFDNQANADAHrKTTAVEILDT 166
Cdd:pfam00291 77 LGLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGDYD--EAVAAARELAAEGPGAYYINQYDNPLNIEGY-GTIGLEILEQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPVLSGG---------QPGPHKIPGTGPGFVPSILNRDI 237
Cdd:pfam00291 154 LGGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDL 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724454841 238 Y----DEILHIEDEDATVMARRLAAEEGIFVGASGAAS-AFMAVQVAKKLPPNAKVLCIAPD 294
Cdd:pfam00291 234 LdeyvGEVVTVSDEEALEAMRLLARREGIVVEPSSAAAlAALKLALAGELKGGDRVVVVLTG 295
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
14-294 |
1.80e-74 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 228.55 E-value: 1.80e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 14 TPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLipGKSTIIEPTSGNTGIGLAMVCAVKGYPCII 93
Cdd:cd00640 1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKL--PKGVIIESTGGNTGIALAAAAARLGLKCTI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 94 TMPDNATKERIKIMKAYGAEVHLTPSEFrmQGSIDEAIRLSKDIPDSFIPMQFDNQANADAHrKTTAVEILDTFDGS-LD 172
Cdd:cd00640 79 VMPEGASPEKVAQMRALGAEVVLVPGDF--DDAIALAKELAEEDPGAYYVNQFDNPANIAGQ-GTIGLEILEQLGGQkPD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 173 AFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPagspvlsggqpgphkipgtgpgfvpsilnrdiydEILHIEDEDATVM 252
Cdd:cd00640 156 AVVVPVGGGGNIAGIARALKELLPNVKVIGVEP----------------------------------EVVTVSDEEALEA 201
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1724454841 253 ARRLAAEEGIFVGASGAASAFMAVQVAKKLPPNAKVLCIAPD 294
Cdd:cd00640 202 IRLLAREEGILVEPSSAAALAAALKLAKKLGKGKTVVVILTG 243
|
|
| PLN02356 |
PLN02356 |
phosphateglycerate kinase |
7-301 |
3.23e-40 |
|
phosphateglycerate kinase
Pssm-ID: 215204 Cd Length: 423 Bit Score: 145.13 E-value: 3.23e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PLN02356 47 LIDAIGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPG-GVVTEGSAGSTAISLATVAPA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVH---------------------LTPSEF----------------RMQGSIDE 129
Cdd:PLN02356 126 YGCKCHVVIPDDVAIEKSQILEALGATVErvrpvsithkdhyvniarrraLEANELaskrrkgsetdgihleKTNGCISE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 130 AIR----LSKDIPDSFIPMQFDNQANADAHRKTTAVEILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEP 205
Cdd:PLN02356 206 EEKenslFSSSCTGGFFADQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQEKNPNIKCFLIDP 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 206 AGSPVLSGGQPG---------------PHKIPGTGPGFVPSILNRDI--YDEILHIEDEDATVMARRLAAEEGIFVGASG 268
Cdd:PLN02356 286 PGSGLFNKVTRGvmytreeaegrrlknPFDTITEGIGINRLTQNFLMakLDGAFRGTDKEAVEMSRYLLKNDGLFVGSSS 365
|
330 340 350
....*....|....*....|....*....|...
gi 1724454841 269 AASAFMAVQVAKKLPPNAKVLCIAPDTGERYLS 301
Cdd:PLN02356 366 AMNCVGAVRVAQSLGPGHTIVTILCDSGMRHLS 398
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
11-303 |
2.33e-26 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 107.21 E-value: 2.33e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 11 VGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLipgksTIIEPTSGNTGIGLAMVCAVKGYP 90
Cdd:COG0498 64 EGGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKDRAMQVAVSLALERGAK-----TIVCASSGNGSAALAAYAARAGIE 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 91 CIITMP-DNATKERIKIMKAYGAEVHLtpsefrMQGSIDEAIRLSKDIpdsfipmqFDNQANADAH-----R----KTTA 160
Cdd:COG0498 139 VFVFVPeGKVSPGQLAQMLTYGAHVIA------VDGNFDDAQRLVKEL--------AADEGLYAVNsinpaRlegqKTYA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 161 VEILDTFDGSLDAFV---------------LtagtggtvtgtgEELKKQ-----LPdlKIYVVEPAG-SPVLSGGQPG-P 218
Cdd:COG0498 205 FEIAEQLGRVPDWVVvptgnggnilagykaF------------KELKELglidrLP--RLIAVQATGcNPILTAFETGrD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 219 HKIPGTGPGFVPSILNRD------IYDEI-------LHIEDEDATVMARRLAAEEGIFVGASGAAsafmAVQVAKKL--- 282
Cdd:COG0498 271 EYEPERPETIAPSMDIGNpsngerALFALresggtaVAVSDEEILEAIRLLARREGIFVEPATAV----AVAGLRKLree 346
|
330 340 350
....*....|....*....|....*....|.
gi 1724454841 283 ---PPNAKVLCIA-------PDTGERYLSSD 303
Cdd:COG0498 347 geiDPDEPVVVLStghglkfPDAVREALGGE 377
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
7-291 |
3.25e-24 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 100.11 E-value: 3.25e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:COG1171 18 IAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASLSEEER----ARGVVAASAGNHAQGVAYAARL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFrmQGSIDEAIRLSKD-----IPDsfipmqFDN------QAnadah 155
Cdd:COG1171 94 LGIPATIVMPETAPAVKVAATRAYGAEVVLHGDTY--DDAEAAAAELAEEegatfVHP------FDDpdviagQG----- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 156 rkTTAVEILDTFD-----------GSLDAFVLTAgtggtvtgtgeeLKKQLPDLKIYVVEPAGSPV----LSGGQPGPHK 220
Cdd:COG1171 161 --TIALEILEQLPdldavfvpvggGGLIAGVAAA------------LKALSPDIRVIGVEPEGAAAmyrsLAAGEPVTLP 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 221 IPGTgpgFV-------PSILNRDIY----DEILHIEDEDATVMARRLAAEEGIFVGASGAAsAFMAVQVAKKLPPNAKVL 289
Cdd:COG1171 227 GVDT---IAdglavgrPGELTFEILrdlvDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAA-ALAALLAGKERLKGKRVV 302
|
..
gi 1724454841 290 CI 291
Cdd:COG1171 303 VV 304
|
|
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
12-291 |
2.55e-22 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 94.97 E-value: 2.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 12 GKTPIVKLNKIPEATGA-EVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgkSTIIEPTSGNTGIGLAMVCAVKGYP 90
Cdd:cd01563 21 GNTPLVRAPRLGERLGGkNLYVKDEGLNPTGSFKDRGMTVAVSKAKELGV-----KAVACASTGNTSASLAAYAARAGIK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 91 CIITMPDNATKERIKIMKAYGAEVHltpsefRMQGSIDEAIRLSKDIPDSFIpmqFDNQANADAHR----KTTAVEILDT 166
Cdd:cd01563 96 CVVFLPAGKALGKLAQALAYGATVL------AVEGNFDDALRLVRELAEENW---IYLSNSLNPYRlegqKTIAFEIAEQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 167 FDGSL-DAFVL---TAGTGGTVTGTGEELKKQ-----LPdlKIYVVEPAG-SPVLSGGQPG-PHKIPGTGPGFVPS---I 232
Cdd:cd01563 167 LGWEVpDYVVVpvgNGGNITAIWKGFKELKELglidrLP--RMVGVQAEGaAPIVRAFKEGkDDIEPVENPETIATairI 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1724454841 233 LNRDIYDEILH-----------IEDEDATVMARRLAAEEGIFVGASGAASafmaVQVAKKL------PPNAKVLCI 291
Cdd:cd01563 245 GNPASGPKALRavresggtavaVSDEEILEAQKLLARTEGIFVEPASAAS----LAGLKKLreegiiDKGERVVVV 316
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
7-291 |
4.69e-22 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 93.71 E-value: 4.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:cd01562 11 IKPVVRRTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLSLSEEER----AKGVVAASAGNHAQGVAYAAKL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFrmQGSIDEAIRLSKDIPDSFIPmQFDN------QAnadahrkTTA 160
Cdd:cd01562 87 LGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDF--DEAEAKARELAEEEGLTFIH-PFDDpdviagQG-------TIG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 161 VEILDTFDGsLDA-FV------------LTagtggtvtgtgeeLKKQLPDLKIYVVEPAGSPVLS----GGQPGPHKIPG 223
Cdd:cd01562 157 LEILEQVPD-LDAvFVpvggggliagiaTA-------------VKALSPNTKVIGVEPEGAPAMAqslaAGKPVTLPEVD 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1724454841 224 T---G-----PGFVPSILNRDIYDEILHIEDEDATVMARRLAAEEGIFVGASGAAsAFMAVQVAKKLPPNAKVLCI 291
Cdd:cd01562 223 TiadGlavkrPGELTFEIIRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGAL-ALAALLSGKLDLKGKKVVVV 297
|
|
| PRK06608 |
PRK06608 |
serine/threonine dehydratase; |
4-173 |
6.38e-18 |
|
serine/threonine dehydratase;
Pssm-ID: 235842 [Multi-domain] Cd Length: 338 Bit Score: 82.51 E-value: 6.38e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 4 YHSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLiPGKstIIEPTSGNTGIGLAMV 83
Cdd:PRK06608 14 HNRIKQYLHLTPIVHSESLNEMLGHEIFFKVESLQKTGAFKVRGVLNHLLELKEQGKL-PDK--IVAYSTGNHGQAVAYA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 84 CAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSefrmQGSIDEAIRLSKDipDSFIPMQFDNQANADAHRKTTAVEI 163
Cdd:PRK06608 91 SKLFGIKTRIYLPLNTSKVKQQAALYYGGEVILTNT----RQEAEEKAKEDEE--QGFYYIHPSDSDSTIAGAGTLCYEA 164
|
170
....*....|
gi 1724454841 164 LDTFDGSLDA 173
Cdd:PRK06608 165 LQQLGFSPDA 174
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
12-137 |
4.50e-16 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 77.05 E-value: 4.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 12 GKTPIVKLNKIPEATG-AEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgkSTIIEPTSGNTGIGLAMVCAVKGYP 90
Cdd:PRK06381 14 GGTPLLRARKLEEELGlRKIYLKFEGANPTGTQKDRIAEAHVRRAMRLGY-----SGITVGTCGNYGASIAYFARLYGLK 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1724454841 91 CIITMPDNATKERIKIMKAYGAEVHLTPsefrmqGSIDEAIRLSKDI 137
Cdd:PRK06381 89 AVIFIPRSYSNSRVKEMEKYGAEIIYVD------GKYEEAVERSRKF 129
|
|
| PRK06815 |
PRK06815 |
threonine/serine dehydratase; |
1-290 |
4.03e-14 |
|
threonine/serine dehydratase;
Pssm-ID: 180709 [Multi-domain] Cd Length: 317 Bit Score: 71.65 E-value: 4.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 1 MNYYHSILDL-------VGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMItraekegKLIPG---KSTIIE 70
Cdd:PRK06815 1 NTLFDAILEAhqrlrpqVRVTPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKL-------RLLNEaqrQQGVIT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 71 PTSGNTGIGLAMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEfrMQGSIDEAIRLSKDIPDSFIPMQFDNQA 150
Cdd:PRK06815 74 ASSGNHGQGVALAAKLAGIPVTVYAPEQASAIKLDAIRALGAEVRLYGGD--ALNAELAARRAAEQQGKVYISPYNDPQV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 151 NADahRKTTAVEILDTFDGsLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGSPV------------------LS 212
Cdd:PRK06815 152 IAG--QGTIGMELVEQQPD-LDAVFVAVGGGGLISGIATYLKTLSPKTEIIGCWPANSPSlytsleageivevaeqptLS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 213 GGQPGphkipGTGPGFVPSILNRDIYDE-ILHIEDEDATVMARRLAAEEGIFVGASGAASAFMaVQVAKKL--PPNAKVL 289
Cdd:PRK06815 229 DGTAG-----GVEPGAITFPLCQQLIDQkVLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAA-LKLAPRYqgKKVAVVL 302
|
.
gi 1724454841 290 C 290
Cdd:PRK06815 303 C 303
|
|
| thrC |
TIGR00260 |
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ... |
5-291 |
8.73e-13 |
|
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 272986 [Multi-domain] Cd Length: 327 Bit Score: 67.79 E-value: 8.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 5 HSILDLV-GKTPIVKLNKIPEATGA-EVFIKLESFNPGGSVKDRAALNMITRAeKEGklipGKSTIIEPTSGNTGIGLAM 82
Cdd:TIGR00260 13 KDLVDLGeGVTPLFRAPALAANVGIkNLYVKELGHNPTLSFKDRGMAVALTKA-LEL----GNDTVLCASTGNTGAAAAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 83 VCAVKGYPCIITMPDNAT-KERIKIMKAYGAEVhltpseFRMQGSIDEAIRLSKDIPDSFIPMQFdNQANADAHR----K 157
Cdd:TIGR00260 88 YAGKAGLKVVVLYPAGKIsLGKLAQALGYNAEV------VAIDGNFDDAQRLVKQLFEDKPALGL-NSANSIPYRlegqK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 158 TTAVEILDTFDGSL-DAFVLTAGTG---GTVTGTGEELKK----QLPDlKIYVVEPAGSPV----LSGGQPGPHKIPGTg 225
Cdd:TIGR00260 161 TYAFEAVEQLGWEApDKVVVPVPNSgnfGAIWKGFKEKKMlgldSLPV-KRGIQAEGAADIvrafLEGGQWEPIETPET- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 226 pgFVPS--ILN--------RDIYDEILHIED--EDATVMA-RRLAAEEGIFVGASGAASafmaVQVAKKL------PPNA 286
Cdd:TIGR00260 239 --LSTAmdIGNpanwpralEAFRRSNGYAEDlsDEEILEAiKLLAREEGYFVEPHSAVA----VAALLKLvekgtaDPAE 312
|
....*
gi 1724454841 287 KVLCI 291
Cdd:TIGR00260 313 RVVCA 317
|
|
| PRK05638 |
PRK05638 |
threonine synthase; Validated |
12-137 |
2.67e-12 |
|
threonine synthase; Validated
Pssm-ID: 235539 [Multi-domain] Cd Length: 442 Bit Score: 66.76 E-value: 2.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 12 GKTPIVKlNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAekegkLIPGKSTIIEPTSGNTGIGLAMVCAVKGYPC 91
Cdd:PRK05638 65 GGTPLIR-ARISEKLGENVYIKDETRNPTGSFRDRLATVAVSYG-----LPYAANGFIVASDGNAAASVAAYSARAGKEA 138
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1724454841 92 IITMPDNATKERIKIMKAYGAEVhltpseFRMQGSIDEAIRLSKDI 137
Cdd:PRK05638 139 FVVVPRKVDKGKLIQMIAFGAKI------IRYGESVDEAIEYAEEL 178
|
|
| PRK08329 |
PRK08329 |
threonine synthase; Validated |
14-136 |
4.31e-12 |
|
threonine synthase; Validated
Pssm-ID: 236244 [Multi-domain] Cd Length: 347 Bit Score: 65.62 E-value: 4.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 14 TPIVKLNKipeatgaEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgkSTIIEPTSGNTGIGLAMVCAVKGYPCII 93
Cdd:PRK08329 65 TPTVKRSI-------KVYFKLDYLQPTGSFKDRGTYVTVAKLKEEGI-----NEVVIDSSGNAALSLALYSLSEGIKVHV 132
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1724454841 94 TMPDNATKERIKIMKAYGAEVHLTPSEfRMQGSiDEAIRLSKD 136
Cdd:PRK08329 133 FVSYNASKEKISLLSRLGAELHFVEGD-RMEVH-EEAVKFSKR 173
|
|
| PRK07048 |
PRK07048 |
threo-3-hydroxy-L-aspartate ammonia-lyase; |
7-206 |
3.43e-11 |
|
threo-3-hydroxy-L-aspartate ammonia-lyase;
Pssm-ID: 235918 [Multi-domain] Cd Length: 321 Bit Score: 63.11 E-value: 3.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PRK07048 18 LAGVAHRTPVLTSRTADARTGAQVFFKCENFQRMGAFKFRGAYNALSQFSPEQR----RAGVVTFSSGNHAQAIALSARL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVhltpSEFRMQGSIDEAI--RLSKDIPDSFIPmQFDNqANADAHRKTTAVEIL 164
Cdd:PRK07048 94 LGIPATIVMPQDAPAAKVAATRGYGGEV----VTYDRYTEDREEIgrRLAEERGLTLIP-PYDH-PHVIAGQGTAAKELF 167
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1724454841 165 DTFdGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPA 206
Cdd:PRK07048 168 EEV-GPLDALFVCLGGGGLLSGCALAARALSPGCKVYGVEPE 208
|
|
| PRK08638 |
PRK08638 |
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB; |
5-121 |
3.74e-11 |
|
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
Pssm-ID: 236317 [Multi-domain] Cd Length: 333 Bit Score: 62.83 E-value: 3.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 5 HSILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMI---TRAEKEgklipgkSTIIEPTSGNTGIGLA 81
Cdd:PRK08638 19 QRLAGRIRKTPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAFNKLsslTDAEKR-------KGVVACSAGNHAQGVA 91
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1724454841 82 MVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEF 121
Cdd:PRK08638 92 LSCALLGIDGKVVMPKGAPKSKVAATCGYGAEVVLHGDNF 131
|
|
| Trp-synth_B |
cd06446 |
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the ... |
9-132 |
1.68e-10 |
|
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to glyceraldehyde 3-phosphate and indole at the active site of the alpha subunit. In the beta reaction, indole undergoes a PLP-dependent reaction with L-serine to form L-tryptophan at the active site of the beta subunit. Members of this CD, Trp-synth_B, are found in all three major phylogenetic divisions.
Pssm-ID: 107207 Cd Length: 365 Bit Score: 61.01 E-value: 1.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 9 DLVGK-TPIVKLNKIPEAT-GAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:cd06446 29 DYVGRpTPLYRAKRLSEYLgGAKIYLKREDLNHTGAHKINNALGQALLAKRMGK----KRVIAETGAGQHGVATATACAL 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITM--PDNATKE-RIKIMKAYGAEVHLTPSEFRMQG-SIDEAIR 132
Cdd:cd06446 105 FGLECEIYMgaVDVERQPlNVFRMELLGAEVVPVPSGSGTLKdAISEAIR 154
|
|
| PRK08197 |
PRK08197 |
threonine synthase; Validated |
4-299 |
2.12e-10 |
|
threonine synthase; Validated
Pssm-ID: 181283 [Multi-domain] Cd Length: 394 Bit Score: 60.78 E-value: 2.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 4 YHSILDLV----------GKTPIVKLNKIPEATGA-EVFIKLESFNPGGSVKDRAALNMITRAeKEgkliPGKSTIIEPT 72
Cdd:PRK08197 60 YHELLPVRdpehivslgeGMTPLLPLPRLGKALGIgRLWVKDEGLNPTGSFKARGLAVGVSRA-KE----LGVKHLAMPT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 73 SGNTGIGLAMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVhltpseFRMQGSIDEAIRLSKDipdsFIPMQ--FDNQA 150
Cdd:PRK08197 135 NGNAGAAWAAYAARAGIRATIFMPADAPEITRLECALAGAEL------YLVDGLISDAGKIVAE----AVAEYgwFDVST 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 151 NADAHR----KTTAVEIldtfdgsldafvltagtggtvtgtGEELKKQLPDLKIY------------------------- 201
Cdd:PRK08197 205 LKEPYRiegkKTMGLEL------------------------AEQLGWRLPDVILYptgggvgligiwkafdelealgwig 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 202 -------VVEPAG-SPVLSGGQ---------PGPHKIpgtGPGF-VPSIL-NRDIYDEI-------LHIEDEDATVMARR 255
Cdd:PRK08197 261 gkrprlvAVQAEGcAPIVKAWEegkeesefwEDAHTV---AFGIrVPKALgDFLVLDAVretggcaIAVSDDAILAAQRE 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1724454841 256 LAAEEGIFVGASGAAsAFMAVQVAKK---LPPNAKVLCIAPDTGERY 299
Cdd:PRK08197 338 LAREEGLFACPEGAA-TFAAARQLREsgwLKGDERVVLFNTGSGLKY 383
|
|
| PRK06110 |
PRK06110 |
threonine dehydratase; |
24-133 |
9.25e-10 |
|
threonine dehydratase;
Pssm-ID: 235699 Cd Length: 322 Bit Score: 58.47 E-value: 9.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 24 EATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPGkstIIEPTSGNTGIGLAMVCAVKGYPCIITMPDNATKER 103
Cdd:PRK06110 32 ERLGCEVWVKHENHTPTGAFKVRGGLVYFDRLARRGPRVRG---VISATRGNHGQSVAFAARRHGLAATIVVPHGNSVEK 108
|
90 100 110
....*....|....*....|....*....|
gi 1724454841 104 IKIMKAYGAEVHLTPSEFrmQGSIDEAIRL 133
Cdd:PRK06110 109 NAAMRALGAELIEHGEDF--QAAREEAARL 136
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
12-129 |
1.18e-09 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 58.59 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 12 GKTPIVKlnkipeatGAEVFIKLESFNPGGSVKDRAALNMITR-AEKegklipGKSTIIEPTSGNTGIGLAMVCAVKGYP 90
Cdd:PRK06450 57 GRTPLIK--------KGNIWFKLDFLNPTGSYKDRGSVTLISYlAEK------GIKQISEDSSGNAGASIAAYGAAAGIE 122
|
90 100 110
....*....|....*....|....*....|....*....
gi 1724454841 91 CIITMPDNATKERIKIMKAYGAEVhltpseFRMQGSIDE 129
Cdd:PRK06450 123 VKIFVPETASGGKLKQIESYGAEV------VRVRGSRED 155
|
|
| L-Ser-dehyd |
cd06448 |
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ... |
13-148 |
4.23e-09 |
|
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
Pssm-ID: 107209 Cd Length: 316 Bit Score: 56.54 E-value: 4.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 13 KTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKliPGKSTIIEPTSGNTGIGLAMVCAVKGYPCI 92
Cdd:cd06448 1 KTPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGL--NECVHVVCSSGGNAGLAAAYAARKLGVPCT 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1724454841 93 ITMPdNATKER-IKIMKAYGAEVHLtpsefrmQGSI----DEAIRL---SKDIPDSFIPmQFDN 148
Cdd:cd06448 79 IVVP-ESTKPRvVEKLRDEGATVVV-------HGKVwweaDNYLREelaENDPGPVYVH-PFDD 133
|
|
| PLN02970 |
PLN02970 |
serine racemase |
7-208 |
8.20e-09 |
|
serine racemase
Pssm-ID: 215524 [Multi-domain] Cd Length: 328 Bit Score: 55.84 E-value: 8.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEgkliPGKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PLN02970 21 IAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDD----QAEKGVVTHSSGNHAAALALAAKL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVHLtpSEFRMQGSIDEAIRLSKDIPDSFIPMQfdNQANADAHRKTTAVEILDT 166
Cdd:PLN02970 97 RGIPAYIVVPKNAPACKVDAVIRYGGIITW--CEPTVESREAVAARVQQETGAVLIHPY--NDGRVISGQGTIALEFLEQ 172
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1724454841 167 FDGsLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGS 208
Cdd:PLN02970 173 VPE-LDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGA 213
|
|
| PRK12483 |
PRK12483 |
threonine dehydratase; Reviewed |
7-208 |
1.03e-08 |
|
threonine dehydratase; Reviewed
Pssm-ID: 237111 [Multi-domain] Cd Length: 521 Bit Score: 55.96 E-value: 1.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PRK12483 31 VYDVARETPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGAYNKMARLPAEQL----ARGVITASAGNHAQGVALAAAR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITMPDNATKERIKIMKAYGAEVHLTPSEFrmQGSIDEAIRLSKDIPDSFIPmQFDNqANADAHRKTTAVEILDT 166
Cdd:PRK12483 107 LGVKAVIVMPRTTPQLKVDGVRAHGGEVVLHGESF--PDALAHALKLAEEEGLTFVP-PFDD-PDVIAGQGTVAMEILRQ 182
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1724454841 167 FDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPAGS 208
Cdd:PRK12483 183 HPGPLDAIFVPVGGGGLIAGIAAYVKYVRPEIKVIGVEPDDS 224
|
|
| PRK08246 |
PRK08246 |
serine/threonine dehydratase; |
13-122 |
1.40e-07 |
|
serine/threonine dehydratase;
Pssm-ID: 181319 [Multi-domain] Cd Length: 310 Bit Score: 51.88 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 13 KTPIVKLNkIPEATGAEVFIKLESFNPGGSVKDRAALN-MITRAEKEgklipgkSTIIEPTSGNTGIGLAMVCAVKGYPC 91
Cdd:PRK08246 23 RTPVLEAD-GAGFGPAPVWLKLEHLQHTGSFKARGAFNrLLAAPVPA-------AGVVAASGGNAGLAVAYAAAALGVPA 94
|
90 100 110
....*....|....*....|....*....|.
gi 1724454841 92 IITMPDNATKERIKIMKAYGAEVHLTPSEFR 122
Cdd:PRK08246 95 TVFVPETAPPAKVARLRALGAEVVVVGAEYA 125
|
|
| eutB |
PRK07476 |
threonine dehydratase; Provisional |
7-165 |
1.79e-07 |
|
threonine dehydratase; Provisional
Pssm-ID: 236025 [Multi-domain] Cd Length: 322 Bit Score: 51.89 E-value: 1.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 7 ILDLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAV 86
Cdd:PRK07476 13 IAGRVRRTPLVASASLSARAGVPVWLKLETLQPTGSFKLRGATNALLSLSAQER----ARGVVTASTGNHGRALAYAARA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 87 KGYPCIITM----PDNATKErikiMKAYGAEVHLTPSefrmqgSIDEA----IRLSKDIPDSFIPmQFDNQAnADAHRKT 158
Cdd:PRK07476 89 LGIRATICMsrlvPANKVDA----IRALGAEVRIVGR------SQDDAqaevERLVREEGLTMVP-PFDDPR-IIAGQGT 156
|
....*..
gi 1724454841 159 TAVEILD 165
Cdd:PRK07476 157 IGLEILE 163
|
|
| PRK08206 |
PRK08206 |
diaminopropionate ammonia-lyase; Provisional |
13-133 |
1.93e-07 |
|
diaminopropionate ammonia-lyase; Provisional
Pssm-ID: 236186 Cd Length: 399 Bit Score: 51.80 E-value: 1.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 13 KTPIVKLNKIPEATG-AEVFIKLESFNPG-GSVK------------------DRAALNMITRAEKEGKLIPGKSTIIEPT 72
Cdd:PRK08206 44 PTPLVALPDLAAELGvGSILVKDESYRFGlNAFKalggayavarllaeklglDISELSFEELTSGEVREKLGDITFATAT 123
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724454841 73 SGNTGIGLAMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHltpsefRMQGSIDEAIRL 133
Cdd:PRK08206 124 DGNHGRGVAWAAQQLGQKAVIYMPKGSSEERVDAIRALGAECI------ITDGNYDDSVRL 178
|
|
| PLN02550 |
PLN02550 |
threonine dehydratase |
1-206 |
3.15e-07 |
|
threonine dehydratase
Pssm-ID: 178165 [Multi-domain] Cd Length: 591 Bit Score: 51.46 E-value: 3.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 1 MNYYHSIL-----DLVGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEgKLIPGkstIIEPTSGN 75
Cdd:PLN02550 92 MEYLTNILsakvyDVAIESPLQLAKKLSERLGVKVLLKREDLQPVFSFKLRGAYNMMAKLPKE-QLDKG---VICSSAGN 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 76 TGIGLAMVCAVKGYPCIITMPDNATKERIKIMKAYGAEVHLtpsefrMQGSIDE----AIRLSKDIPDSFIPmQFDNqAN 151
Cdd:PLN02550 168 HAQGVALSAQRLGCDAVIAMPVTTPEIKWQSVERLGATVVL------VGDSYDEaqayAKQRALEEGRTFIP-PFDH-PD 239
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1724454841 152 ADAHRKTTAVEILDTFDGSLDAFVLTAGTGGTVTGTGEELKKQLPDLKIYVVEPA 206
Cdd:PLN02550 240 VIAGQGTVGMEIVRQHQGPLHAIFVPVGGGGLIAGIAAYVKRVRPEVKIIGVEPS 294
|
|
| PRK13803 |
PRK13803 |
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional |
4-132 |
4.51e-07 |
|
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional
Pssm-ID: 237513 [Multi-domain] Cd Length: 610 Bit Score: 50.97 E-value: 4.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 4 YHSIL-DLVGK-TPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLA 81
Cdd:PRK13803 260 FKRLLqNYAGRpTPLTEAKRLSDIYGARIYLKREDLNHTGSHKINNALGQALLAKRMGK----TRIIAETGAGQHGVATA 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1724454841 82 MVCAVKGYPCIITMPDNATKERIK---IMKAYGAEVHLTPSEFR-MQGSIDEAIR 132
Cdd:PRK13803 336 TACALFGLKCTIFMGEEDIKRQALnveRMKLLGANVIPVLSGSKtLKDAVNEAIR 390
|
|
| PLN02569 |
PLN02569 |
threonine synthase |
29-168 |
2.35e-06 |
|
threonine synthase
Pssm-ID: 178182 [Multi-domain] Cd Length: 484 Bit Score: 48.66 E-value: 2.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 29 EVFIKLESFNPGGSVKDR---AALNMITRAEKEGKLIPGKSTiiePTSGNTGIGLAMVCAVKGYPCIITMP-DNATKERI 104
Cdd:PLN02569 151 DLWVKHCGISHTGSFKDLgmtVLVSQVNRLRKMAKPVVGVGC---ASTGDTSAALSAYCAAAGIPSIVFLPaDKISIAQL 227
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1724454841 105 KIMKAYGAEVhltpseFRMQGSIDEAIRLSKDIpDSFIPMQFDNQANA--DAHRKTTAVEILDTFD 168
Cdd:PLN02569 228 VQPIANGALV------LSIDTDFDGCMRLIREV-TAELPIYLANSLNSlrLEGQKTAAIEILQQFD 286
|
|
| PLN02618 |
PLN02618 |
tryptophan synthase, beta chain |
21-132 |
8.34e-06 |
|
tryptophan synthase, beta chain
Pssm-ID: 215333 Cd Length: 410 Bit Score: 47.06 E-value: 8.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 21 KIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAVKGYPCIITMpDNAT 100
Cdd:PLN02618 80 KRADGEGPEIYLKREDLNHTGAHKINNAVAQALLAKRLGK----KRIIAETGAGQHGVATATVCARFGLECIVYM-GAQD 154
|
90 100 110
....*....|....*....|....*....|....*..
gi 1724454841 101 KERIKI----MKAYGAEVHLTPS-EFRMQGSIDEAIR 132
Cdd:PLN02618 155 MERQALnvfrMRLLGAEVRPVHSgTATLKDATSEAIR 191
|
|
| PRK07334 |
PRK07334 |
threonine dehydratase; Provisional |
11-116 |
1.69e-05 |
|
threonine dehydratase; Provisional
Pssm-ID: 235994 [Multi-domain] Cd Length: 403 Bit Score: 46.04 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 11 VGKTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALN---MITRAEKEgklipgkSTIIEPTSGNTGIGLAMVCAVK 87
Cdd:PRK07334 21 VLRTPCVHSRTLSQITGAEVWLKFENLQFTASFKERGALNkllLLTEEERA-------RGVIAMSAGNHAQGVAYHAQRL 93
|
90 100 110
....*....|....*....|....*....|.
gi 1724454841 88 GYPCIITMPdnATKERIKIM--KAYGAEVHL 116
Cdd:PRK07334 94 GIPATIVMP--RFTPTVKVErtRGFGAEVVL 122
|
|
| PRK09224 |
PRK09224 |
threonine ammonia-lyase IlvA; |
13-211 |
5.76e-05 |
|
threonine ammonia-lyase IlvA;
Pssm-ID: 236417 [Multi-domain] Cd Length: 504 Bit Score: 44.36 E-value: 5.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 13 KTPIVKLNKIPEATGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAVKGYPCI 92
Cdd:PRK09224 20 ETPLEKAPKLSARLGNQVLLKREDLQPVFSFKLRGAYNKMAQLTEEQL----ARGVITASAGNHAQGVALSAARLGIKAV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 93 ITMPdnATKERIKI--MKAYGAEVHLTPSEFrmqgsiDEA----IRLSKDIPDSFIPmQFDNQAnADAHRKTTAVEILDT 166
Cdd:PRK09224 96 IVMP--VTTPDIKVdaVRAFGGEVVLHGDSF------DEAyahaIELAEEEGLTFIH-PFDDPD-VIAGQGTIAMEILQQ 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1724454841 167 FDGSLDA-FV------LTAGTGGtvtgtgeeLKKQL-PDLKIYVVEPAGSPVL 211
Cdd:PRK09224 166 HPHPLDAvFVpvggggLIAGVAA--------YIKQLrPEIKVIGVEPEDSACL 210
|
|
| PRK08813 |
PRK08813 |
threonine dehydratase; Provisional |
30-139 |
6.06e-05 |
|
threonine dehydratase; Provisional
Pssm-ID: 236339 [Multi-domain] Cd Length: 349 Bit Score: 44.23 E-value: 6.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 30 VFIKLESFNPGGSVKDRAALNMITRAEKEGKLIPgkstIIEPTSGNTGIGLAMVCAVKGYPCIITMPDNATKERIKIMKA 109
Cdd:PRK08813 50 VWLKLENLQRTGSYKVRGALNALLAGLERGDERP----VICASAGNHAQGVAWSAYRLGVQAITVMPHGAPQTKIAGVAH 125
|
90 100 110
....*....|....*....|....*....|.
gi 1724454841 110 YGAEVhltpsefRMQG-SIDEAIRLSKDIPD 139
Cdd:PRK08813 126 WGATV-------RQHGnSYDEAYAFARELAD 149
|
|
| PRK13028 |
PRK13028 |
tryptophan synthase subunit beta; Provisional |
14-141 |
7.97e-04 |
|
tryptophan synthase subunit beta; Provisional
Pssm-ID: 183851 Cd Length: 402 Bit Score: 40.62 E-value: 7.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 14 TPIVKLNKIPEA-TGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGKlipgKSTIIEPTSGNTGIGLAMVCAVKGYPCI 92
Cdd:PRK13028 63 TPLYHAKRLSEElGGAQIYLKREDLNHTGAHKINNCLGQALLAKRMGK----KRLIAETGAGQHGVATATAAALFGLECE 138
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1724454841 93 ITM-PDNATKE-----RIKIMkayGAEVH-LTPSEFRMQGSIDEAIR-LSKDIPDSF 141
Cdd:PRK13028 139 IYMgEVDIERQhpnvfRMKLL---GAEVVpVTRGGRTLKEAVDSAFEdYLKDPDNTH 192
|
|
| PRK12391 |
PRK12391 |
TrpB-like pyridoxal phosphate-dependent enzyme; |
14-121 |
3.02e-03 |
|
TrpB-like pyridoxal phosphate-dependent enzyme;
Pssm-ID: 237087 Cd Length: 427 Bit Score: 39.01 E-value: 3.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724454841 14 TPIVKLNKIPEA--TGAEVFIKLESFNPGGSVKDRAALNMITRAEKEGklipgkstiIEPTSGNTGIG-----LAMVCAV 86
Cdd:PRK12391 78 TPLIRARRLEKAlgTPAKIYYKYEGVSPTGSHKPNTAVAQAYYNKKEG---------IKRLTTETGAGqwgsaLALACAL 148
|
90 100 110
....*....|....*....|....*....|....*...
gi 1724454841 87 KGYPCIITMPD---NATKERIKIMKAYGAEVHLTPSEF 121
Cdd:PRK12391 149 FGLECTVFMVRvsyEQKPYRRSLMETYGAEVIPSPSDL 186
|
|
|