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Conserved domains on  [gi|1727959765|ref|WP_147734339|]
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transposase, partial [Escherichia coli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
InsQ super family cl34004
Transposase [Mobilome: prophages, transposons];
1-65 8.55e-26

Transposase [Mobilome: prophages, transposons];


The actual alignment was detected with superfamily member COG0675:

Pssm-ID: 440439 [Multi-domain]  Cd Length: 381  Bit Score: 97.27  E-value: 8.55e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1727959765   1 LQRQLSRKVKFSNNWQKQKRKIQRLHSCIANIRRDYLHKVTTTVSKNHAMIVIEDLKVSNMSKSA 65
Cdd:COG0675   217 LQRRLSRKKKGSKNRRKARKKLAKLHEKIANQRKDFLHKLARKLVKEADVIVVEDLNVKGMKKNK 281
 
Name Accession Description Interval E-value
InsQ COG0675
Transposase [Mobilome: prophages, transposons];
1-65 8.55e-26

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 440439 [Multi-domain]  Cd Length: 381  Bit Score: 97.27  E-value: 8.55e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1727959765   1 LQRQLSRKVKFSNNWQKQKRKIQRLHSCIANIRRDYLHKVTTTVSKNHAMIVIEDLKVSNMSKSA 65
Cdd:COG0675   217 LQRRLSRKKKGSKNRRKARKKLAKLHEKIANQRKDFLHKLARKLVKEADVIVVEDLNVKGMKKNK 281
OrfB_IS605 pfam01385
Probable transposase; This family includes IS891, IS1136 and IS1341. DUF1225, pfam06774, has ...
 2-63 2.28e-19

Probable transposase; This family includes IS891, IS1136 and IS1341. DUF1225, pfam06774, has now been merged into this family.


Pssm-ID: 396108 [Multi-domain]  Cd Length: 120  Bit Score: 75.41  E-value: 2.28e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1727959765   2 QRQLSRKVKFSNNWQKQKRKIQRLHSCIANIRRDYLHKVTTTVSKNHAMIVIEDLKVSNMSK 63
Cdd:pfam01385  57 IARLQRKLKGSNNRKKASRKLARLHRKRSRRRKDFLHKLVRRLIEELDEVGVEDLNVGGMKD 118
guided_TnpB NF040570
RNA-guided endonuclease TnpB family protein; This family includes RNA-guided endonuclease TnpB ...
 1-68 1.54e-16

RNA-guided endonuclease TnpB family protein; This family includes RNA-guided endonuclease TnpB from IS200/IS605 family elements (NF038281) and IS607 family elements (NF038280), but also many additional proteins. It exhibits homolog to or actually includes some CRISPR-associated (Cas) proteins such as the type V CRISPR-associated protein C2c8. For a long time, TnpB proteins were described as accessory proteins in IS (insertion sequence) elements, present as one of just one or two proteins encoded in the element but not necessary for transposition. The programmable RNA-guided endonuclease TnpB proteins may provide a CRISPR-like, widespread form of phage defense by RNA-guided DNA degradation.


Pssm-ID: 468544 [Multi-domain]  Cd Length: 384  Bit Score: 71.81  E-value: 1.54e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727959765   1 LQRQLSRKVKFSNNWQKQKRKIQRLHSCIANIRRDYLHKVTTTVSKNHAM--IVIEDLKVSNMSKSAAGT 68
Cdd:NF040570  234 LSRKLQRKGKGSSNRKKARKKVARLHRKIANQRKDFLHKLSKRLVKEADAnnVVVEDLEVKGMVKNKKKK 303
 
Name Accession Description Interval E-value
InsQ COG0675
Transposase [Mobilome: prophages, transposons];
1-65 8.55e-26

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 440439 [Multi-domain]  Cd Length: 381  Bit Score: 97.27  E-value: 8.55e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1727959765   1 LQRQLSRKVKFSNNWQKQKRKIQRLHSCIANIRRDYLHKVTTTVSKNHAMIVIEDLKVSNMSKSA 65
Cdd:COG0675   217 LQRRLSRKKKGSKNRRKARKKLAKLHEKIANQRKDFLHKLARKLVKEADVIVVEDLNVKGMKKNK 281
OrfB_IS605 pfam01385
Probable transposase; This family includes IS891, IS1136 and IS1341. DUF1225, pfam06774, has ...
 2-63 2.28e-19

Probable transposase; This family includes IS891, IS1136 and IS1341. DUF1225, pfam06774, has now been merged into this family.


Pssm-ID: 396108 [Multi-domain]  Cd Length: 120  Bit Score: 75.41  E-value: 2.28e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1727959765   2 QRQLSRKVKFSNNWQKQKRKIQRLHSCIANIRRDYLHKVTTTVSKNHAMIVIEDLKVSNMSK 63
Cdd:pfam01385  57 IARLQRKLKGSNNRKKASRKLARLHRKRSRRRKDFLHKLVRRLIEELDEVGVEDLNVGGMKD 118
guided_TnpB NF040570
RNA-guided endonuclease TnpB family protein; This family includes RNA-guided endonuclease TnpB ...
 1-68 1.54e-16

RNA-guided endonuclease TnpB family protein; This family includes RNA-guided endonuclease TnpB from IS200/IS605 family elements (NF038281) and IS607 family elements (NF038280), but also many additional proteins. It exhibits homolog to or actually includes some CRISPR-associated (Cas) proteins such as the type V CRISPR-associated protein C2c8. For a long time, TnpB proteins were described as accessory proteins in IS (insertion sequence) elements, present as one of just one or two proteins encoded in the element but not necessary for transposition. The programmable RNA-guided endonuclease TnpB proteins may provide a CRISPR-like, widespread form of phage defense by RNA-guided DNA degradation.


Pssm-ID: 468544 [Multi-domain]  Cd Length: 384  Bit Score: 71.81  E-value: 1.54e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727959765   1 LQRQLSRKVKFSNNWQKQKRKIQRLHSCIANIRRDYLHKVTTTVSKNHAM--IVIEDLKVSNMSKSAAGT 68
Cdd:NF040570  234 LSRKLQRKGKGSSNRKKARKKVARLHRKIANQRKDFLHKLSKRLVKEADAnnVVVEDLEVKGMVKNKKKK 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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