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Conserved domains on  [gi|1731202892|ref|WP_148456950|]
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OmpA family protein [Formosa maritima]

Protein Classification

OmpA family protein( domain architecture ID 11458387)

OmpA family membrane protein acts as a porin with low permeability that allows slow penetration of small solutes; may function in peptidoglycan binding

CATH:  3.30.1330.60
Gene Ontology:  GO:0009279|GO:0015288|GO:0042834
PubMed:  22986056|17559395
SCOP:  4001470
TCDB:  1.B.6

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 51-274 6.58e-21

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 89.84  E-value: 6.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892  51 EGLDIQKISIYGFTDDRGSDSYNLVLSQERADAIKTIFSNNEFDETIITNVDGKGEILIKLIKEEDLNKIRGLNRKVEII 130
Cdd:COG2885    71 ELLDAGSLSATAAAGAAALLVLLAALGALGAGLAALLLAIAAAASAAAADALALAAGAAAALGALGASAAAAAAALAAAK 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892 131 IQPYNPPRDLTVIPEKKNTTESILDENLKAGDKILLENILFKTGYSTLLPESKKTLEDIATVLVDRKDIYFTIQGHvccT 210
Cdd:COG2885   151 ALGDSAAAALDAAAKAEAAAAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGH---T 227

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1731202892 211 qnsrDAIDRKTKQRNLSLARAKYIYDYLAKKGVDKRRMKYVGMRRKFPLGGEP-----KFDRRVEILIT 274
Cdd:COG2885   228 ----DSRGSDAYNLALSERRAEAVKDYLVSKGIPASRITAVGYGESRPVASNDteegrAKNRRVEIVVL 292
 
Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 51-274 6.58e-21

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 89.84  E-value: 6.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892  51 EGLDIQKISIYGFTDDRGSDSYNLVLSQERADAIKTIFSNNEFDETIITNVDGKGEILIKLIKEEDLNKIRGLNRKVEII 130
Cdd:COG2885    71 ELLDAGSLSATAAAGAAALLVLLAALGALGAGLAALLLAIAAAASAAAADALALAAGAAAALGALGASAAAAAAALAAAK 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892 131 IQPYNPPRDLTVIPEKKNTTESILDENLKAGDKILLENILFKTGYSTLLPESKKTLEDIATVLVDRKDIYFTIQGHvccT 210
Cdd:COG2885   151 ALGDSAAAALDAAAKAEAAAAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGH---T 227

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1731202892 211 qnsrDAIDRKTKQRNLSLARAKYIYDYLAKKGVDKRRMKYVGMRRKFPLGGEP-----KFDRRVEILIT 274
Cdd:COG2885   228 ----DSRGSDAYNLALSERRAEAVKDYLVSKGIPASRITAVGYGESRPVASNDteegrAKNRRVEIVVL 292
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 25-131 4.33e-19

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 80.29  E-value: 4.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892  25 VVYFETDQFEVPETEHNRLLMFLSEIEGLDIQKISIYGFTDDRGSDSYNLVLSQERADAIKTIFSNNEFDETIITnVDGK 104
Cdd:cd07185     3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKGVDASRIT-AVGY 81

                          90       100
                  ....*....|....*....|....*..
gi 1731202892 105 GEilIKLIKEEDLNKIRGLNRKVEIII 131
Cdd:cd07185    82 GE--SRPIASNDTEEGRAKNRRVEIVI 106
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 171-253 1.09e-08

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 51.59  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892 171 FKTGYSTLLPESKKTLEDIATVLV-DRKDIYFTIQGHVCCTQNSRDAIDrktkqrnLSLARAKYIYDYLAKKGVDKRRMK 249
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKfPELKNTITIEGHTDTVGSAAYNWE-------LSQRRAEAVRRYLVNFGVPPSRIS 73


                  ....
gi 1731202892 250 YVGM 253
Cdd:pfam00691  74 VVGY 77
motB PRK08944
flagellar motor protein MotB; Reviewed
 156-273 5.85e-05

flagellar motor protein MotB; Reviewed


Pssm-ID: 236356 [Multi-domain]  Cd Length: 302  Bit Score: 43.84  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892 156 ENLkaGDKILL---ENILFKTGYSTLLPESKKTLEDIATVLVDRKDIyFTIQGHvccTQNSRDAIDRKTKQRNLSLARAK 232
Cdd:PRK08944  167 ESL--GQQIIIrirEKGSFPSGSAFLQPKFKPVVRKIGELLKDVPGI-ITVSGH---TDNVPISSELYRSNWDLSSARAV 240

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1731202892 233 YIYDYLAK-KGVDKRRMKYVGMRRKFPLGGEP-----KFDRRVEILI 273
Cdd:PRK08944  241 AVAHELLKvKGFDPQRLKVVGMADTQPLVPNDtaenrARNRRVEIII 287
 
Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 51-274 6.58e-21

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 89.84  E-value: 6.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892  51 EGLDIQKISIYGFTDDRGSDSYNLVLSQERADAIKTIFSNNEFDETIITNVDGKGEILIKLIKEEDLNKIRGLNRKVEII 130
Cdd:COG2885    71 ELLDAGSLSATAAAGAAALLVLLAALGALGAGLAALLLAIAAAASAAAADALALAAGAAAALGALGASAAAAAAALAAAK 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892 131 IQPYNPPRDLTVIPEKKNTTESILDENLKAGDKILLENILFKTGYSTLLPESKKTLEDIATVLVDRKDIYFTIQGHvccT 210
Cdd:COG2885   151 ALGDSAAAALDAAAKAEAAAAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGH---T 227

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1731202892 211 qnsrDAIDRKTKQRNLSLARAKYIYDYLAKKGVDKRRMKYVGMRRKFPLGGEP-----KFDRRVEILIT 274
Cdd:COG2885   228 ----DSRGSDAYNLALSERRAEAVKDYLVSKGIPASRITAVGYGESRPVASNDteegrAKNRRVEIVVL 292
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 26-133 1.66e-19

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 85.99  E-value: 1.66e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892  26 VYFETDQFEVPETEHNRLLMFLSEIEGLDIQKISIYGFTDDRGSDSYNLVLSQERADAIKTIFSNNEFDETIITnVDGKG 105
Cdd:COG2885   189 VYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGHTDSRGSDAYNLALSERRAEAVKDYLVSKGIPASRIT-AVGYG 267

                          90       100
                  ....*....|....*....|....*...
gi 1731202892 106 EilIKLIKEEDLNKIRGLNRKVEIIIQP 133
Cdd:COG2885   268 E--SRPVASNDTEEGRAKNRRVEIVVLK 293
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 25-131 4.33e-19

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 80.29  E-value: 4.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892  25 VVYFETDQFEVPETEHNRLLMFLSEIEGLDIQKISIYGFTDDRGSDSYNLVLSQERADAIKTIFSNNEFDETIITnVDGK 104
Cdd:cd07185     3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKGVDASRIT-AVGY 81

                          90       100
                  ....*....|....*....|....*..
gi 1731202892 105 GEilIKLIKEEDLNKIRGLNRKVEIII 131
Cdd:cd07185    82 GE--SRPIASNDTEEGRAKNRRVEIVI 106
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 168-273 1.07e-16

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 73.74  E-value: 1.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892 168 NILFKTGYSTLLPESKKTLEDIATVLVDRKDIYFTIQGHvccTqnsrDAIDRKTKQRNLSLARAKYIYDYLAKKGVDKRR 247
Cdd:cd07185     3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGH---T----DSRGSDAYNQELSERRAEAVADYLVSKGVDASR 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1731202892 248 MKYVGMRRKFPLG------GEPKfDRRVEILI 273
Cdd:cd07185    76 ITAVGYGESRPIAsndteeGRAK-NRRVEIVI 106
MotB COG1360
Flagellar motor protein MotB [Cell motility];
165-274 3.22e-10

Flagellar motor protein MotB [Cell motility];


Pssm-ID: 440971 [Multi-domain]  Cd Length: 174  Bit Score: 57.93  E-value: 3.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892 165 LLENILFKTGYSTLLPESKKTLEDIATVLVDrKDIYFTIQGHVcctqnsrDAIDRKTKQRN----LSLARAKYIYDYLAK 240
Cdd:COG1360    57 IQDRVLFDSGSAELTPEGRELLDKIAAVLAE-VPNRIRVEGHT-------DNVPISTARFPsnweLSAARAAAVVRYLIE 128

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1731202892 241 KGVDKRRMKYVGM--RRKFPLGGEPKFD---RRVEILIT 274
Cdd:COG1360   129 GGVPPERLSAVGYgdTRPLAPNDTPEGRarnRRVEIVIL 167
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 171-253 1.09e-08

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 51.59  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892 171 FKTGYSTLLPESKKTLEDIATVLV-DRKDIYFTIQGHVCCTQNSRDAIDrktkqrnLSLARAKYIYDYLAKKGVDKRRMK 249
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKfPELKNTITIEGHTDTVGSAAYNWE-------LSQRRAEAVRRYLVNFGVPPSRIS 73


                  ....
gi 1731202892 250 YVGM 253
Cdd:pfam00691  74 VVGY 77
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 28-106 6.48e-06

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 43.89  E-value: 6.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892  28 FETDQFEVPETEHNRLLMFLSEIEGLDIQK-ISIYGFTDDRGSDSYNLVLSQERADAIKTIFSNNEFDETIITnVDGKGE 106
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKFPELKNtITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNFGVPPSRIS-VVGYGA 79
motB PRK08944
flagellar motor protein MotB; Reviewed
 156-273 5.85e-05

flagellar motor protein MotB; Reviewed


Pssm-ID: 236356 [Multi-domain]  Cd Length: 302  Bit Score: 43.84  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892 156 ENLkaGDKILL---ENILFKTGYSTLLPESKKTLEDIATVLVDRKDIyFTIQGHvccTQNSRDAIDRKTKQRNLSLARAK 232
Cdd:PRK08944  167 ESL--GQQIIIrirEKGSFPSGSAFLQPKFKPVVRKIGELLKDVPGI-ITVSGH---TDNVPISSELYRSNWDLSSARAV 240

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1731202892 233 YIYDYLAK-KGVDKRRMKYVGMRRKFPLGGEP-----KFDRRVEILI 273
Cdd:PRK08944  241 AVAHELLKvKGFDPQRLKVVGMADTQPLVPNDtaenrARNRRVEIII 287
PRK10802 PRK10802
peptidoglycan-associated lipoprotein Pal;
19-85 3.84e-04

peptidoglycan-associated lipoprotein Pal;


Pssm-ID: 182744 [Multi-domain]  Cd Length: 173  Bit Score: 40.24  E-value: 3.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1731202892  19 QAQLTHVVYFETDQFEVpETEHNRLL----MFLSEIEGLdiqKISIYGFTDDRGSDSYNLVLSQERADAIK 85
Cdd:PRK10802   64 QLQQNNIVYFDLDKYDI-RSDFAQMLdahaNFLRSNPSY---KVTVEGHADERGTPEYNIALGERRANAVK 130
MotB COG1360
Flagellar motor protein MotB [Cell motility];
56-138 4.24e-04

Flagellar motor protein MotB [Cell motility];


Pssm-ID: 440971 [Multi-domain]  Cd Length: 174  Bit Score: 40.21  E-value: 4.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731202892  56 QKISIYGFTDDR---GSDSY-NLVLSQERADAIKTIFSNNEFDETIITnVDGKGEIliKLIKEEDLNKIRGLNRKVEIII 131
Cdd:COG1360    90 NRIRVEGHTDNVpisTARFPsNWELSAARAAAVVRYLIEGGVPPERLS-AVGYGDT--RPLAPNDTPEGRARNRRVEIVI 166


                  ....*..
gi 1731202892 132 QPYNPPR 138
Cdd:COG1360   167 LRRAAEE 173
PRK10808 PRK10808
outer membrane protein A; Reviewed
 48-90 1.92e-03

outer membrane protein A; Reviewed


Pssm-ID: 236764 [Multi-domain]  Cd Length: 351  Bit Score: 39.29  E-value: 1.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1731202892  48 SEIEGLDIQ--KISIYGFTDDRGSDSYNLVLSQERADAI------KTIFSN 90
Cdd:PRK10808  248 SQLSNLDPKdgSVVVLGYTDRIGSDAYNQGLSEKRAQSVvdylvsKGIPAD 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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