N-6 DNA methylase family protein might be a component of a type I or type IC restriction system and protect the host DNA from digestion via sequence-specific methylation
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
119-416
3.26e-95
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.
The actual alignment was detected with superfamily member pfam02384:
Pssm-ID: 426749 [Multi-domain] Cd Length: 310 Bit Score: 289.22 E-value: 3.26e-95
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
119-416
3.26e-95
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.
Pssm-ID: 426749 [Multi-domain] Cd Length: 310 Bit Score: 289.22 E-value: 3.26e-95
type I restriction system adenine methylase (hsdM); Function: methylation of specific adenine ...
68-433
1.79e-59
type I restriction system adenine methylase (hsdM); Function: methylation of specific adenine residues; required for both restriction and modification activities. The ECOR124/3 I enzyme recognizes 5'GAA(N7)RTCG. for E.coli see (J. Mol. Biol. 257: 960-969 (1996)). [DNA metabolism, Restriction/modification]
Pssm-ID: 211578 [Multi-domain] Cd Length: 501 Bit Score: 202.49 E-value: 1.79e-59
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
119-416
3.26e-95
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.
Pssm-ID: 426749 [Multi-domain] Cd Length: 310 Bit Score: 289.22 E-value: 3.26e-95
type I restriction system adenine methylase (hsdM); Function: methylation of specific adenine ...
68-433
1.79e-59
type I restriction system adenine methylase (hsdM); Function: methylation of specific adenine residues; required for both restriction and modification activities. The ECOR124/3 I enzyme recognizes 5'GAA(N7)RTCG. for E.coli see (J. Mol. Biol. 257: 960-969 (1996)). [DNA metabolism, Restriction/modification]
Pssm-ID: 211578 [Multi-domain] Cd Length: 501 Bit Score: 202.49 E-value: 1.79e-59
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
151-242
1.57e-07
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.
Pssm-ID: 395932 [Multi-domain] Cd Length: 184 Bit Score: 51.20 E-value: 1.57e-07
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440663 [Multi-domain] Cd Length: 172 Bit Score: 41.86 E-value: 1.85e-04
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443299 [Multi-domain] Cd Length: 238 Bit Score: 39.36 E-value: 2.28e-03
Eco57I restriction-modification methylase; homologs of the Escherichia coli Eco57I ...
232-347
4.40e-03
Eco57I restriction-modification methylase; homologs of the Escherichia coli Eco57I restriction-modification methylase are found in several phylogenetically diverse bacteria. The structure of TaqI has been solved.
Pssm-ID: 369456 [Multi-domain] Cd Length: 104 Bit Score: 36.51 E-value: 4.40e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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