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Conserved domains on  [gi|1741214738|ref|WP_149606344|]
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MULTISPECIES: NarK family nitrate/nitrite MFS transporter [Pseudoalteromonas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0108 super family cl36759
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 17-434 1.12e-64

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


The actual alignment was detected with superfamily member TIGR00886:

Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 212.93  E-value: 1.12e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  17 KVLHLSWMVFFVSFFVWFNHAPLL-GAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIP 95
Cdd:TIGR00886   1 RNLFFSWFGFFLSFLVWFAFSPLAvFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  96 CFMFAMAT-TFEQAAIARFALGFIGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFGGEDG-- 172
Cdd:TIGR00886  81 CLWAGLAVqSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGqp 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 173 ----WRYAVGLtgvlsVIFGIIWylnvtdtpkggtyfkpkkvgamevtskgdfvlllimkipMYGALALLTWKLSPTGAN 248
Cdd:TIGR00886 161 ahlaWGWAFVI-----VPAGILL---------------------------------------LPALLIFFVGADTPPGKP 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 249 LISANFVLAVyaflvllyiyevyktfdvnghifkepvpeSHRYEFKQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALD 328
Cdd:TIGR00886 197 ATGKLSFKEA-----------------------------LKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLS 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 329 MVYAGILASAYAFMNLASRPGGGWISDKLGRRI--TLIVLTMGLAVGYFVMGLVDASWpLWLAVVAAMACSFFVQAGEGA 406
Cdd:TIGR00886 248 KVQAGAYASLGGFLGSLARPAGGAISDRLGGARklLMNFLGVAMGAFLVVLGLVSDGS-LAAFIVLFVALFFFAGAGNGS 326

                         410       420
                  ....*....|....*....|....*...
gi 1741214738 407 VFAAVPLIKRRLTGQIAGMTGAYGNVGA 434
Cdd:TIGR00886 327 TFALVPHIFRRATGAVSGLIGAIGNLGG 354
 
Name Accession Description Interval E-value
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 17-434 1.12e-64

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 212.93  E-value: 1.12e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  17 KVLHLSWMVFFVSFFVWFNHAPLL-GAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIP 95
Cdd:TIGR00886   1 RNLFFSWFGFFLSFLVWFAFSPLAvFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  96 CFMFAMAT-TFEQAAIARFALGFIGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFGGEDG-- 172
Cdd:TIGR00886  81 CLWAGLAVqSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGqp 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 173 ----WRYAVGLtgvlsVIFGIIWylnvtdtpkggtyfkpkkvgamevtskgdfvlllimkipMYGALALLTWKLSPTGAN 248
Cdd:TIGR00886 161 ahlaWGWAFVI-----VPAGILL---------------------------------------LPALLIFFVGADTPPGKP 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 249 LISANFVLAVyaflvllyiyevyktfdvnghifkepvpeSHRYEFKQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALD 328
Cdd:TIGR00886 197 ATGKLSFKEA-----------------------------LKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLS 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 329 MVYAGILASAYAFMNLASRPGGGWISDKLGRRI--TLIVLTMGLAVGYFVMGLVDASWpLWLAVVAAMACSFFVQAGEGA 406
Cdd:TIGR00886 248 KVQAGAYASLGGFLGSLARPAGGAISDRLGGARklLMNFLGVAMGAFLVVLGLVSDGS-LAAFIVLFVALFFFAGAGNGS 326

                         410       420
                  ....*....|....*....|....*...
gi 1741214738 407 VFAAVPLIKRRLTGQIAGMTGAYGNVGA 434
Cdd:TIGR00886 327 TFALVPHIFRRATGAVSGLIGAIGNLGG 354
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 19-466 4.49e-59

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 199.40  E-value: 4.49e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  19 LHLSWMVFFVSFFVWFNHAPLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFM 98
Cdd:cd17341     1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  99 FAMA-TTFEQAAIARFALGFIGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIA---LMFGGEDGWR 174
Cdd:cd17341    81 LALAvSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAgaiVFDGGFVGWR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 175 YAVGLTGVLSVIFGIIWYLNVTDTPKGGTyfkpkkvgamevtskgdfvlllimkipmygalalltwklsptganliSANF 254
Cdd:cd17341   161 NAFFVPGILLAIAAVLVLLFGDDLPTGKA-----------------------------------------------SALE 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 255 VLAVYaflvllyiyevyktfdvnghifkepvpeSHRYEFKQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGI 334
Cdd:cd17341   194 FLKVQ----------------------------LAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGI 245

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 335 LASAYAFMNLASRPGGGWISDKLG-RRITLIVLT-MGLAVGYFVMGLVDASWPLWLAVVAAMACSFFVQAGEGAVFAAVP 412
Cdd:cd17341   246 LAALFPLAGALARPAGGWLSDRFGgRRRLWWLFIvMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVP 325

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1741214738 413 LIKRRLTGQIAGMTGAYGNVGAVVYLTALSLVDYQTFFFIIAGSALLGLAALFF 466
Cdd:cd17341   326 FIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACT 379
PLN00028 PLN00028
nitrate transmembrane transporter; Provisional
 7-436 6.35e-58

nitrate transmembrane transporter; Provisional


Pssm-ID: 177665 [Multi-domain]  Cd Length: 476  Bit Score: 198.61  E-value: 6.35e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738   7 FNLISF-KGKMKVLHLSWMVFFVSFFVWFNHAPLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVY 85
Cdd:PLN00028   25 FRLFSFaRPHMRAFHLSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGS 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  86 AALLISCSIPCFMFAMATTFEQAAIARFALGFIGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPI--- 162
Cdd:PLN00028  105 AFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIAAGWGNLGGGVTQLLMPLvfp 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 163 -IALMFG-GEDGWRYAVGLTGVLSVIFGIIWYLNVTDTPKgGTYFKPKKVGAMEvtsKGDFvllliMKIPMYGALALLTW 240
Cdd:PLN00028  185 lIKDAGApSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPD-GNYRELKKSGTMP---KDSF-----SKVLRYGVTNYRTW 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 241 klsptganlisanfvlavyaFLVLLYIYevyktfdvnghifkepvpeshryefkqvavlnilyftTFGSELAVVSMLPLF 320
Cdd:PLN00028  256 --------------------ILALTYGY-------------------------------------SFGVELTMDNIIAEY 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 321 FMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITL--------IVLTMGlAVGYFVMGLVDAswpLWLAVVA 392
Cdd:PLN00028  279 FYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARRFGMrgrlwalwIVQTLG-GVFCIWLGRANS---LGAAIVV 354

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1741214738 393 AMACSFFVQAGEGAVFAAVPLIKRRLTGQIAGMTGAYGNVGAVV 436
Cdd:PLN00028  355 MILFSIFVQAACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVL 398
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
13-467 9.87e-50

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 174.68  E-value: 9.87e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  13 KGKMKVLHLSWMVFFVSFFVWFNHAPLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISC 92
Cdd:COG2223     1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  93 SIPCFMFAMATTFEQAAIARFALGF-IGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFgged 171
Cdd:COG2223    81 GIGLLLLALAVSYWLLLLLGLLLGIgGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 172 GWRYAVGLTGVLSVIFGIIWYLNVTDTPKGGTYFKPKKVGAMevtskgdfvlllimkipmygalalltwklsptganlis 251
Cdd:COG2223   157 GWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ-------------------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 252 anfvlavyaflvllyiyevyktfdvnGHIFKEPvpeshryefkQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVY 331
Cdd:COG2223   199 --------------------------LEALRDP----------RFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 332 AGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLvdASWPLWLAVVAAMACSFFVQAGEGAVFAAV 411
Cdd:COG2223   243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL--ALGSLWLFLVLFLLLGLALGGGNGAVFALV 320

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1741214738 412 PLI-KRRLTGQIAGMTGAYGNVGAVVYLTALSLV-----DYQTFFFIIAGSALLGLAALFFM 467
Cdd:COG2223   321 PDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFGALldatgSYTAAFLVFAVLALVALVLTLLL 382
MFS_1 pfam07690
Major Facilitator Superfamily;
39-436 1.24e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 68.98  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  39 LLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG-F 117
Cdd:pfam07690  19 LPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGlG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 118 IGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIFGIIWYLNVTD 197
Cdd:pfam07690  99 AGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----GWRAAFLILAILSLLAAVLLLLPRPP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 198 TPKGGTYFKPKKvgamevtskgdfvlllimkipmygalalltwklsptganlisanfvlavyaflvllyiyeVYKTFDVN 277
Cdd:pfam07690 175 PESKRPKPAEEA------------------------------------------------------------RLSLIVAW 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 278 GHIFKEPvpeshryefkqVAVLNILYFTTFGSELAVVSMLPLfFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKL 357
Cdd:pfam07690 195 KALLRDP-----------VLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 358 GRRITLIVLTMGLAVGYFVMGLVDASWPLWLAVVAAMACSFFVQAGEGAVFAAVP-LIKRRLTGQIAGMTGAYGNVGAVV 436
Cdd:pfam07690 263 GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSdLAPKEERGTASGLYNTAGSLGGAL 342
 
Name Accession Description Interval E-value
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 17-434 1.12e-64

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 212.93  E-value: 1.12e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  17 KVLHLSWMVFFVSFFVWFNHAPLL-GAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIP 95
Cdd:TIGR00886   1 RNLFFSWFGFFLSFLVWFAFSPLAvFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  96 CFMFAMAT-TFEQAAIARFALGFIGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFGGEDG-- 172
Cdd:TIGR00886  81 CLWAGLAVqSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGqp 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 173 ----WRYAVGLtgvlsVIFGIIWylnvtdtpkggtyfkpkkvgamevtskgdfvlllimkipMYGALALLTWKLSPTGAN 248
Cdd:TIGR00886 161 ahlaWGWAFVI-----VPAGILL---------------------------------------LPALLIFFVGADTPPGKP 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 249 LISANFVLAVyaflvllyiyevyktfdvnghifkepvpeSHRYEFKQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALD 328
Cdd:TIGR00886 197 ATGKLSFKEA-----------------------------LKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLS 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 329 MVYAGILASAYAFMNLASRPGGGWISDKLGRRI--TLIVLTMGLAVGYFVMGLVDASWpLWLAVVAAMACSFFVQAGEGA 406
Cdd:TIGR00886 248 KVQAGAYASLGGFLGSLARPAGGAISDRLGGARklLMNFLGVAMGAFLVVLGLVSDGS-LAAFIVLFVALFFFAGAGNGS 326

                         410       420
                  ....*....|....*....|....*...
gi 1741214738 407 VFAAVPLIKRRLTGQIAGMTGAYGNVGA 434
Cdd:TIGR00886 327 TFALVPHIFRRATGAVSGLIGAIGNLGG 354
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 19-466 4.49e-59

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 199.40  E-value: 4.49e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  19 LHLSWMVFFVSFFVWFNHAPLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFM 98
Cdd:cd17341     1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  99 FAMA-TTFEQAAIARFALGFIGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIA---LMFGGEDGWR 174
Cdd:cd17341    81 LALAvSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAgaiVFDGGFVGWR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 175 YAVGLTGVLSVIFGIIWYLNVTDTPKGGTyfkpkkvgamevtskgdfvlllimkipmygalalltwklsptganliSANF 254
Cdd:cd17341   161 NAFFVPGILLAIAAVLVLLFGDDLPTGKA-----------------------------------------------SALE 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 255 VLAVYaflvllyiyevyktfdvnghifkepvpeSHRYEFKQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGI 334
Cdd:cd17341   194 FLKVQ----------------------------LAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGI 245

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 335 LASAYAFMNLASRPGGGWISDKLG-RRITLIVLT-MGLAVGYFVMGLVDASWPLWLAVVAAMACSFFVQAGEGAVFAAVP 412
Cdd:cd17341   246 LAALFPLAGALARPAGGWLSDRFGgRRRLWWLFIvMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVP 325

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1741214738 413 LIKRRLTGQIAGMTGAYGNVGAVVYLTALSLVDYQTFFFIIAGSALLGLAALFF 466
Cdd:cd17341   326 FIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACT 379
PLN00028 PLN00028
nitrate transmembrane transporter; Provisional
 7-436 6.35e-58

nitrate transmembrane transporter; Provisional


Pssm-ID: 177665 [Multi-domain]  Cd Length: 476  Bit Score: 198.61  E-value: 6.35e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738   7 FNLISF-KGKMKVLHLSWMVFFVSFFVWFNHAPLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVY 85
Cdd:PLN00028   25 FRLFSFaRPHMRAFHLSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGS 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  86 AALLISCSIPCFMFAMATTFEQAAIARFALGFIGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPI--- 162
Cdd:PLN00028  105 AFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIAAGWGNLGGGVTQLLMPLvfp 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 163 -IALMFG-GEDGWRYAVGLTGVLSVIFGIIWYLNVTDTPKgGTYFKPKKVGAMEvtsKGDFvllliMKIPMYGALALLTW 240
Cdd:PLN00028  185 lIKDAGApSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPD-GNYRELKKSGTMP---KDSF-----SKVLRYGVTNYRTW 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 241 klsptganlisanfvlavyaFLVLLYIYevyktfdvnghifkepvpeshryefkqvavlnilyftTFGSELAVVSMLPLF 320
Cdd:PLN00028  256 --------------------ILALTYGY-------------------------------------SFGVELTMDNIIAEY 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 321 FMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITL--------IVLTMGlAVGYFVMGLVDAswpLWLAVVA 392
Cdd:PLN00028  279 FYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARRFGMrgrlwalwIVQTLG-GVFCIWLGRANS---LGAAIVV 354

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1741214738 393 AMACSFFVQAGEGAVFAAVPLIKRRLTGQIAGMTGAYGNVGAVV 436
Cdd:PLN00028  355 MILFSIFVQAACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVL 398
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
13-467 9.87e-50

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 174.68  E-value: 9.87e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  13 KGKMKVLHLSWMVFFVSFFVWFNHAPLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISC 92
Cdd:COG2223     1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  93 SIPCFMFAMATTFEQAAIARFALGF-IGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFgged 171
Cdd:COG2223    81 GIGLLLLALAVSYWLLLLLGLLLGIgGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 172 GWRYAVGLTGVLSVIFGIIWYLNVTDTPKGGTYFKPKKVGAMevtskgdfvlllimkipmygalalltwklsptganlis 251
Cdd:COG2223   157 GWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ-------------------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 252 anfvlavyaflvllyiyevyktfdvnGHIFKEPvpeshryefkQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVY 331
Cdd:COG2223   199 --------------------------LEALRDP----------RFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 332 AGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLvdASWPLWLAVVAAMACSFFVQAGEGAVFAAV 411
Cdd:COG2223   243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL--ALGSLWLFLVLFLLLGLALGGGNGAVFALV 320

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1741214738 412 PLI-KRRLTGQIAGMTGAYGNVGAVVYLTALSLV-----DYQTFFFIIAGSALLGLAALFFM 467
Cdd:COG2223   321 PDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFGALldatgSYTAAFLVFAVLALVALVLTLLL 382
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
37-467 4.52e-22

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 97.25  E-value: 4.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  37 APLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG 116
Cdd:COG2271    30 SVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 117 F-IGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIFGIIwylnv 195
Cdd:COG2271   110 LgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF----GWRAAFLILGLPGLLLALL----- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 196 tdtpkggtyfkpkkvgamevtskgdfvlllimkipmygalalltwklsptganlisanfvlavyaflvllyiyevyktfd 275
Cdd:COG2271       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 276 vnghifkepvpeshryefkQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISD 355
Cdd:COG2271   181 -------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 356 KLGRR--ITLIVLTMGLAVGYFVMGLVDaswPLWLAVVAAMACSFFVQAGEGAVFAAVP-LIKRRLTGQIAGMTGAYGNV 432
Cdd:COG2271   242 RLGRRrkLVLAIGLLLAALALLLLALLP---SPALAIALLFLAGFGLGGAFGLLWALAAeLFPKKARGTASGLVNTFGFL 318

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1741214738 433 GA----VVYLTALSLVDYQTFFFIIAGSALLGLAALFFM 467
Cdd:COG2271   319 GGalgpLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 70-467 3.07e-18

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 86.09  E-value: 3.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  70 VVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGFIGAG-FVVGIRMVSEWFPANELGIAEGIYGGW 148
Cdd:cd17319    56 VPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGfFPGAIKALAEWFPARERGRATGLFNSG 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 149 GNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIFGIIWYLNVtdtpkggtyfkpkkvgamevtskGDFVLLLIMK 228
Cdd:cd17319   136 APLGAAIGPPLSGWLLLLF----GWRWAFIIEGLLGLLLAVLWWFYL-----------------------RQVWGLALGY 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 229 IPMYGAL-ALLTWklsptganlisanfvlavyaflvllyiyevyktfdvnghifkepvpeshryefkqvavlnilyfttf 307
Cdd:cd17319   189 FGINYALyGLLTW------------------------------------------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 308 gselavvsmLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLVDASWPLW 387
Cdd:cd17319   202 ---------LPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPV 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 388 LAVVAAMACSFFVQAGEGAVFAAVP-LIKRRLTGQIAGMTGAYGNVGAVVYLTALSLV-----DYQTFFFIIAGSALLGL 461
Cdd:cd17319   273 VAVILLSLAGFGIGAASPVFWSLPAdLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLvdatgSYTAAFLFLAAVALLAA 352


                  ....*.
gi 1741214738 462 AALFFM 467
Cdd:cd17319   353 LLVLLL 358
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
37-434 6.96e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 72.70  E-value: 6.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  37 APLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG 116
Cdd:COG2814    30 LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 117 FIGAGFVVGIR-MVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIfgiiwylnv 195
Cdd:COG2814   110 LGAGALFPAALaLIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----GWRWVFLVNAVLALL--------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 196 tdtpkggtyfkpkkvgamevtskgdfvlllimkipmygaLALLTWKLSPTGANLISANFVLAVYAFLVllyiyevyktfd 275
Cdd:COG2814   177 ---------------------------------------ALLLLLRLLPESRPAARARLRGSLRELLR------------ 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 276 vnghifkepvpeshryeFKQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISD 355
Cdd:COG2814   206 -----------------RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1741214738 356 KLGRRITLIVLTMGLAVGYFVMGLVDASWPLWLAVVAAMACSFFVQAGEGAVFAAvpLIKRRLTGQIAGMTGAYGNVGA 434
Cdd:COG2814   269 RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE--LAPPEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
39-436 1.24e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 68.98  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  39 LLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG-F 117
Cdd:pfam07690  19 LPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGlG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 118 IGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIFGIIWYLNVTD 197
Cdd:pfam07690  99 AGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----GWRAAFLILAILSLLAAVLLLLPRPP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 198 TPKGGTYFKPKKvgamevtskgdfvlllimkipmygalalltwklsptganlisanfvlavyaflvllyiyeVYKTFDVN 277
Cdd:pfam07690 175 PESKRPKPAEEA------------------------------------------------------------RLSLIVAW 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 278 GHIFKEPvpeshryefkqVAVLNILYFTTFGSELAVVSMLPLfFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKL 357
Cdd:pfam07690 195 KALLRDP-----------VLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 358 GRRITLIVLTMGLAVGYFVMGLVDASWPLWLAVVAAMACSFFVQAGEGAVFAAVP-LIKRRLTGQIAGMTGAYGNVGAVV 436
Cdd:pfam07690 263 GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSdLAPKEERGTASGLYNTAGSLGGAL 342
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 46-199 5.78e-12

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 67.02  E-value: 5.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  46 SLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGFI-GAGFVV 124
Cdd:TIGR00881  24 EIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFqGMGWPP 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1741214738 125 GIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFGgedGWRYAVGLTGVLSVIFGIIWYLNVTDTP 199
Cdd:TIGR00881 104 CGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY---SWHWVFIVPGIIAIIVSLICFLLLRDSP 175
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 70-464 3.20e-11

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 64.95  E-value: 3.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  70 VVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGFIGAGFV-VGIRMVSEWFPANELGIAEGIYGGW 148
Cdd:cd17475    49 LPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQpGGGRAIMRWFPPRERGLAMGIRQTG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 149 GNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIFGIIWYLnvtdtpkggtyFKPKKVGAMEVTSKGDFVLLLIMK 228
Cdd:cd17475   129 VPLGGALAAALLPPLALHY----GWRAAFVVAGLVSILAAVLFWL-----------FYREPPAASAATESASTLLRSLKE 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 229 IPMYGALalltWKLSPTGANLISANFVLAVYaflvllyiyevyktfdvnghifkepvpeshryefkqvavlnilyfttfg 308
Cdd:cd17475   194 VLRNRDV----WLIAIAGALLVAPQFALLTF------------------------------------------------- 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 309 selavvsmLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKL--GRRITLIVLTMGLAVG-YFVMGLVDASWP 385
Cdd:cd17475   221 --------LLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAaLLVLSLLSPGTP 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 386 LWLAVVAAMACSFFVQAGEGAVFAAVP-LIKRRLTGQIAGMTGAYGNVGAVVYLTALSLV-----DYQTFFFIIAGSALL 459
Cdd:cd17475   293 LWLLVLLLILLGLFAIGWNGLYLTLVAeSAGPEQAGTALGLANTINFIGIAIGPPLFGLLvdathSYAPAWLALALLLVL 372


                  ....*
gi 1741214738 460 GLAAL 464
Cdd:cd17475   373 AALLL 377
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
37-470 3.86e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 61.43  E-value: 3.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  37 APLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG 116
Cdd:COG2807    38 GPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIG 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 117 F-IGAGFVVGIRMVSEWFPANeLGIAEGIYGGWGNFGSAAAAMLLPIIALMFGgedgWRYAVGLTGVLSVIFGIIWYLNV 195
Cdd:COG2807   118 AgIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALG----WRGALAVWALLALLALLLWLPLL 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 196 TDTPKGGTYFKPKKVGAMEVTSKgdfvlllimkipmygalalLTWklsptganlisanfVLAVYAFLVLLYIYevyktfd 275
Cdd:COG2807   193 RRRPAAAAAAPAAASLRSLWRSP-------------------LAW--------------LLTLFFGLQSLLYY------- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 276 vnghifkepvpeshryefkqvavlnilyfttfgselAVVSMLPLFFMDvFALDMVYAGILASAYAFMNLASRPGGGWISD 355
Cdd:COG2807   233 ------------------------------------AVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 356 KLGRRITLIVLTMGL-AVGYFVMGLVDASWPLWLAVVAAMACsffvqageGAVFAAVP-LIKRRL-----TGQIAGMTGA 428
Cdd:COG2807   276 RLGDRRPLLLLLGLLgLAGLLGLLLAPGSLPWLWAVLLGLGQ--------GGLFPLALtLIGLRArtpaeAAALSGMAQS 347

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1741214738 429 YGNVGAVVYLTALSLV-----DYQTFFFIIAGSALLGLAALFFMTEP 470
Cdd:COG2807   348 VGYLLAALGPLLVGALhdatgSWTAALLLLAALAVLMLVAGLLAGRP 394
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 37-467 4.25e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.44  E-value: 4.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  37 APLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG 116
Cdd:cd17325    16 IPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 117 FIGAGF-VVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIFGIIWYLNV 195
Cdd:cd17325    96 LASAAVwPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL----GYRAPFLVCAALALLALVLALLLL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 196 TDTPkggtyfKPKKVGAMEVTSKGDFVLLLIMKipmygalalltwklsptganlisanfvlavyaflvllyiyevyktfd 275
Cdd:cd17325   172 PEPR------PPPNKRAVSAARLRSGLRLLLRD----------------------------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 276 vnghifkepvpeshryefKQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISD 355
Cdd:cd17325   199 ------------------RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 356 KLGRRITLIVLTMGLAVGYFVMGLVDASWPLWLAVVAAMACSFFVQAGEGAVFAAVplIKRRLTGQIAGMTGAYGNVGAV 435
Cdd:cd17325   261 RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI--VPPEGRGTAMGLFNTAFSLGMV 338

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1741214738 436 V-YLTALSLVDYQTFFFIIAGSALLGLAALFFM 467
Cdd:cd17325   339 LgPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 73-465 9.44e-10

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 60.37  E-value: 9.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  73 GMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG-FIGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNF 151
Cdd:cd17312    59 GFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGlFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNF 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 152 GSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIFGIIWYLNVTDTPKGgtyfkpkkvgamevtskgdfvlllimkipm 231
Cdd:cd17312   139 GGILAPILAASLASYY----GWRAAFLVPGIVGLVVAIILFFFLRDSPPY------------------------------ 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 232 ygalalltwklsptganlisanfvlavyaflvllyiyevyktfdvnghifkepvpeshryefkqVAVLNILYFTTFGSEL 311
Cdd:cd17312   185 ----------------------------------------------------------------VWVLSLAYAFVYIVRY 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 312 AVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLG---RRITLIVLTMGLAVGYFVMGLVDASWplWL 388
Cdd:cd17312   201 ACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFggrRAPIAVIYMLLMTLSLALFWFFPHNK--LL 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 389 AVVAAMACSFFVQAGEG--AVFAAVPLIKRRLTGQIAGMTGAYGNVGAVVYLTALSLV----DYQTFFFIIAGSALLGLA 462
Cdd:cd17312   279 SIVLLFLIGFFVGGPINliGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIidhyGWSTVFYFLISAALLSVL 358


                  ...
gi 1741214738 463 ALF 465
Cdd:cd17312   359 LLL 361
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 37-466 3.05e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 58.59  E-value: 3.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  37 APLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG 116
Cdd:cd06174    16 SPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 117 FIGAGF-VVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFGGedGWRYAVGLTGVLSVIFGIIWYLNV 195
Cdd:cd06174    96 LGSGLIdPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF--GWRAVFLIAAALALLAAILLLLVV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 196 TDTPKGGTYFKPKKVGAMEVTSkgdfvLLLIMKIPMYGALAlltwklsptganlisanfvlavyaflvllyiyevyktfd 275
Cdd:cd06174   174 PDPPESARAKNEEASSKSVLKL-----LKRVLKNPGLWLLL--------------------------------------- 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 276 vnghifkepvpeshryefkqvavlnILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISD 355
Cdd:cd06174   210 -------------------------LAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 356 KLGRRITLIVLTM-GLAVGYFVMGLVDASWPLWLAVVAAMACSFFVQAGEGAVFA-AVPLIKRRLTGQIAGMTGAYGNVG 433
Cdd:cd06174   265 RLIGRKPLLLIGLlLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAeLFPPEIRGTAFGLLNTFGFLGGAI 344

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1741214738 434 AVVYLTALSLVDYQTFFFIIAGSALLGLAALFF 466
Cdd:cd06174   345 GPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
286-467 2.78e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.37  E-value: 2.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 286 PESHRYEFKQVAVLNILYFTTFGSELAVVSMLPLFfMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIV 365
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 366 LTMGLAVGYFVMGLVDASWPLWLA-VVAAMACSFFVQAGEGAVFAAVPLIKR-RLTGQIAGMTGAYGNVGAVVYLTALSL 443
Cdd:COG2814    81 GLLLFALGSLLCALAPSLWLLLAArFLQGLGAGALFPAALALIADLVPPERRgRALGLLGAGLGLGPALGPLLGGLLADL 160

                         170       180
                  ....*....|....*....|....
gi 1741214738 444 VDYQTFFFIIAGSALLGLAALFFM 467
Cdd:COG2814   161 FGWRWVFLVNAVLALLALLLLLRL 184
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 296-470 6.24e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.44  E-value: 6.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 296 VAVLNILYFTTFGselAVVSMLPLFFMDVFALDMVyAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYF 375
Cdd:cd17489     1 ILLANFFFFLSFY---LLLPVLPLYAHDLGGSEAV-AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 376 VMGLVDASWPLWLAVVAAMACSFFVQAGEGAVfaAVPLIKRRLTGQIAGMTGAYGNVGAVVY----LTALSLVDYQTFFF 451
Cdd:cd17489    77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATL--VADIIPPSRRGEGIGYYGLATTLAMALGpalgLFLYQHLGFAVLFI 154

                         170
                  ....*....|....*....
gi 1741214738 452 IIAGSALLGLAALFFMTEP 470
Cdd:cd17489   155 VAAVLALLALLLVFLVKDP 173
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 37-465 1.09e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 50.63  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  37 APLLGAIAGSLGITMAQVKTLL---ILNVALTIParvVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARF 113
Cdd:cd17324    19 QGLLPDIARDFGVSVAQAGLLVsayALGYALGAL---LLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 114 ALGFIGAGFV-VGIRMVSEWFPANELGIAEGIYGGwgnfGSAAAAMLLPIIALMFGGEDGWRYAVGLTGVLSVIfgiiwy 192
Cdd:cd17324    96 LAGLAHGGFWaIAAAYAADLVPPEKRGRAIGLVFS----GLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL------ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 193 lnvtdtpkggtyfkpkkvgamevtskgdfvlllimkipmygaLALLTWKLSPTGANLISANfvlavyaflvllyiyevYK 272
Cdd:cd17324   166 ------------------------------------------AALLLWRLLPSLPPKKPGS-----------------LG 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 273 TFDVNGHIFKEPvpeshryefkQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGW 352
Cdd:cd17324   187 LLSSLLLLLRNP----------RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 353 ISDKLGRRITLIVLTMGLAVGYFVMGLVDAswpLWLAVVAAMACSFFVQAGEGAVFAAVPLIKRRLTGQIAGM-TGAY-- 429
Cdd:cd17324   257 LADRGGRRALLIALLLLAAALLLLTLLGPS---PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLyLAAYnl 333

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1741214738 430 -GNVGAVVYLTALSLVDYQTFFFIIAGSALLGLAALF 465
Cdd:cd17324   334 gGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
43-192 1.11e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.65  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  43 IAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGFIGAGF 122
Cdd:COG2223   232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG 311

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1741214738 123 VVGI--RMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFGGEDGWRYAVGLTGVLSVIFGIIWY 192
Cdd:COG2223   312 GNGAvfALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 71-199 1.41e-06

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 50.32  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  71 VVGMLTDKFGPRIVYAALLISCSIPCFMFAMA----TTFEQAAIARFALGFI-GAGFVVGIRMVSEWFPANELGIAEGIY 145
Cdd:cd17345    57 VMGNLSDRSNPKRFLAIGLILSAIINILIGFVpsatSSVGLMFILLFLNGWFqGMGWPPSGRTMVHWFSKKERGTWTSIW 136

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1741214738 146 GGWGNFGSAAAAMLLpIIALMFGGEDGWRYAVGLTGVLSVIFGIIWYLNVTDTP 199
Cdd:cd17345   137 NISHNVGGGLVGPLA-GLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTP 189
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
296-488 2.00e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 49.88  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 296 VAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYF 375
Cdd:COG2223     6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 376 VMGLVDASWPLwlavvaaMACSFFVQAGEGAVFA-AVPLI----KRRLTGQIAGMTGAYGNVGAVV--YLTALSLVDY-- 446
Cdd:COG2223    86 LLALAVSYWLL-------LLLGLLLGIGGGGSFAvGIALVskwfPPDRRGLALGLAAGGGNLGAAVaaFLAPLLIAAFgw 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1741214738 447 -QTFFFIIAGSALLGLAALFFMTEPDGHITEVNEDGTVELISV 488
Cdd:COG2223   159 rNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEA 201
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 311-466 2.19e-06

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 49.92  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 311 LAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLVDASWPLwlaV 390
Cdd:cd17353   230 LMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVL---F 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 391 VAAMACSFFVQAGEGAVFAAvplikrrLTGQIAGMT-------------GAYGNVGAVVYLTALSLVDYQTFFFIIAGSA 457
Cdd:cd17353   307 VLGVALIGFCYGGGFALFPA-------LTADFFGTKnagtnygllytakGVGGLIGPIIAAYVLYTGGYNAAFIIAAALS 379


                  ....*....
gi 1741214738 458 LLGLAALFF 466
Cdd:cd17353   380 LVALALALL 388
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 312-466 2.27e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.53  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 312 AVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLVDASWPLWLAVV 391
Cdd:cd17329    17 MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1741214738 392 AAMACSFFVQAGEGAVFAAVPLIKRRLTGQIAGMTGayGNVGAVV--YLTALSLVDYQTFFFIIAGSALLGLAALFF 466
Cdd:cd17329    97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWA--INLGVAIgpLLGGLLLLYSFRLLFLAAAVLFLLAALVLL 171
MFS_1 pfam07690
Major Facilitator Superfamily;
299-470 3.14e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 3.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 299 LNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMG 378
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 379 LVDASWPLWLA-VVAAMACSFFVQAGEGAVFAAVPLIKR-RLTGQIAGMTGAYGNVGAVVYLTALSLVDYQTFFFIIAGS 456
Cdd:pfam07690  81 FASSLWLLLVLrVLQGLGAGALFPAALALIADWFPPEERgRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170
                  ....*....|....
gi 1741214738 457 ALLGLAALFFMTEP 470
Cdd:pfam07690 161 SLLAAVLLLLPRPP 174
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
293-436 4.94e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 48.70  E-value: 4.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 293 FKQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAV 372
Cdd:COG0738   209 NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAV 288

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1741214738 373 GYFVMGLVDAswpLWLAVVAAMACSFFVQAGEGAVFAAVPLIKRRLTGQIAGMTGAYGNVGAVV 436
Cdd:COG0738   289 GLLLALLAPG---PWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAI 349
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 39-199 1.09e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 47.68  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  39 LLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGF- 117
Cdd:cd17371    21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLg 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 118 IGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFGGEDGWRYAVgLTGVLSVIFGIIWYLNVTD 197
Cdd:cd17371   101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLF-LLGALPALLVLFIRRFVKE 179


                  ..
gi 1741214738 198 TP 199
Cdd:cd17371   180 PP 181
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 37-240 1.56e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.18  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  37 APLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG 116
Cdd:cd17474    19 DPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 117 FIGAGF-VVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMfggedGWRYAVGLTGVLSVIFGIIWYLNV 195
Cdd:cd17474    99 IGAAGLgPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-----SWRYPFFLLAALIPVAFLAILFLL 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1741214738 196 TDTPKGGTYFKPKKVGAME--VTSKGDFVLLLIMKIPMYGALALLTW 240
Cdd:cd17474   174 PEPKEKAKSSSATKLRDLKkaLRGRGLLTFLVSAFLYFFLYFAFLTY 220
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 302-379 2.07e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 46.45  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 302 LYFTTFGSELAVVSMLPLFFMDVFALDM--VYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGL 379
Cdd:cd17390     1 LYLVGFLDLFGVSMILPLLSTHIRSLGAspTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 37-265 2.42e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 45.96  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  37 APLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG 116
Cdd:COG0477    34 NVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQG 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 117 F-IGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFggedGWRYAVGLtGVLSVIFGIIWYLNV 195
Cdd:COG0477   114 IgAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL----GWRWIFLI-NAPLGLLALVLRLRL 188

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 196 TDTPKGGTYFKPKKVGAMEVTSKGDFVLLLIMKIPMYGALALLTWKLSPTGANLISANFVLAVYAFLVLL 265
Cdd:COG0477   189 PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLL 258
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
293-395 3.20e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.43  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 293 FKQVAVLNILYFTTFGselAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAV 372
Cdd:COG2211   230 FLLLLLAYLLFFLALA---LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306

                          90       100
                  ....*....|....*....|...
gi 1741214738 373 GYFVMGLVDASWPLWLAVVAAMA 395
Cdd:COG2211   307 GLLLLFFLGPGNLWLLLVLAALA 329
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 46-192 3.32e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 46.06  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  46 SLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGF-IGAGFVV 124
Cdd:cd17316    30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgIGGEYPG 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1741214738 125 GIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFGGEDGWRYAVGLTGVLSVIFGIIWY 192
Cdd:cd17316   110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRR 177
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 74-208 4.19e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 45.70  E-value: 4.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  74 MLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGFIGAGFVVGIRMV-SEWFPANELGIAEGIYGGWGNFG 152
Cdd:cd17327    63 LLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYlGMWYKREEQAKRIAFFYAAAGLG 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1741214738 153 SAAAAMLLPIIALM--FGGEDGWRYAVGLTGVLSVIFGIIWYLNVTDTPKGGTYFKPK 208
Cdd:cd17327   143 SIFGGLLAYGVFKIlgVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEE 200
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
18-200 5.44e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 45.25  E-value: 5.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  18 VLHLSWMVFFVSFFVWFNHAPLLgaIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPR--IVYAALLISCSIP 95
Cdd:COG2271   184 LLALAYFLVYFALYGFLTWLPTY--LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  96 CFMFAMATTFEQAAIARFALGF-IGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFggedGWR 174
Cdd:COG2271   262 LLLLALLPSPALAIALLFLAGFgLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT----GYQ 337

                         170       180
                  ....*....|....*....|....*.
gi 1741214738 175 YAVGLTGVLSVIFGIIWYLNVTDTPK 200
Cdd:COG2271   338 AAFLLLAALALLAALLALLLLRETRK 363
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 294-436 5.64e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.24  E-value: 5.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 294 KQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVG 373
Cdd:cd17321   168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1741214738 374 YFVMGLVDASWPLWLAVVAAMACS----FFVQAGEGAVFAAVPlikRRLTGQIAGMTGAYGNVGAVV 436
Cdd:cd17321   248 LLLLALLGADSSVWLLLPGLVLLGlglgLFATPLTNAALSSVP---KEKAGAASGILNTARQLGGAL 311
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 304-466 6.53e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.88  E-value: 6.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 304 FTTFGSELAVVSMLPLFFMD--VFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLvd 381
Cdd:cd17330     6 FLDALGFGIVFPVLPFYVREfnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL-- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 382 aSWPLWLAVVAAMACSFFVqAGEGAVFAAV-----PLIKRRLTGQIAGMTGAYGNVGAVVYLTALSLVDYQTFFFIIAGS 456
Cdd:cd17330    84 -SRNLWLLFLARFLDGLTG-GNVSVAQAYIaditdEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAAL 161

                         170
                  ....*....|
gi 1741214738 457 ALLGLAALFF 466
Cdd:cd17330   162 ALLNLVLVLF 171
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 38-186 7.60e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 44.95  E-value: 7.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  38 PLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGF 117
Cdd:cd17355    24 VFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGG 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1741214738 118 IGAG--FVVGIRMVSEWFPANELGIAEGIYGGWGNFGSaaaAMLLPIIALMfGGEDGWRYAVGLTGVLSVI 186
Cdd:cd17355   104 GGAGtlAAVAFATVAAWWFERRRGLALGILTAGGGLGS---LVFLPLGAAL-IEAFGWRTALLVLALLALL 170
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 304-488 9.88e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.49  E-value: 9.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 304 FTTFGSELAVVSMLPLFFMDvFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLVDAS 383
Cdd:cd17325     6 FLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 384 WPLWLA-VVAAMACSFFVQAGEGAVFAAVPLIKR-RLTGQIAGMTGAYGNVGAVVYLTALSLVDYQTFFFIIAGSALLGL 461
Cdd:cd17325    85 WQLLLArFLQGLASAAVWPAAMALIADIAPPEERgRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLAL 164

                         170       180
                  ....*....|....*....|....*..
gi 1741214738 462 AALFFMTEPDGHITEVNEDGTVELISV 488
Cdd:cd17325   165 VLALLLLPEPRPPPNKRAVSAARLRSG 191
2_A_01_02 TIGR00880
Multidrug resistance protein;
71-198 1.16e-04

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 42.25  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  71 VVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGFIGA-GFVVGIRMVSEWFPANELGIAEGIYGGwg 149
Cdd:TIGR00880  17 LSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAfALVAGAALIADIYPPEERGVALGLMSA-- 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1741214738 150 nfGSAAAAMLLPIIALMFGGEDGWRYAVGLTGVLSVIFGIIWYLNVTDT 198
Cdd:TIGR00880  95 --GIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
293-468 3.43e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 293 FKQVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISD----KLGRRITLIVL-T 367
Cdd:COG2211     9 LKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIgA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 368 MGLAVGYFVMGLVDA---SWPLWLAVVAAMACSFFVQAGEGAVFAAVPLI------------KRRLTGQIAGMTGAYGNV 432
Cdd:COG2211    89 IPLALSFVLLFTAPDlspTGKLIYALVTYLLLGLAYTLVNIPYSALGAELtpdyeertrlssWRFAFAGLGGLLASVLPP 168

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1741214738 433 GAVVYLTALSLVDYQTFFFIIAGSALLGLAALFFMT 468
Cdd:COG2211   169 PLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGT 204
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
 71-200 4.95e-04

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 42.39  E-value: 4.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  71 VVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGFI-GAGFVVGIRMVSEWFPANELGIAEGIYGGWG 149
Cdd:cd17488    57 VSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLWTLNAFFqGWGWPPCARLLTHWYSRNERGFWWSIWNTSH 136

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1741214738 150 NFGSAAAAMLLPIIALMFGgedgWRYAVGLTGVLSVIFGIIWYLNVTDTPK 200
Cdd:cd17488   137 NIGGALIPILTGFAALTYG----WRAGMYVPGIIAILMGIVLCWRLRDRPP 183
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 43-193 5.45e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 42.17  E-value: 5.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  43 IAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGP----RIVYAALLISCSIPCFMFAMATTFEQAAIARFALGFI 118
Cdd:cd17319   206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarrLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGI 285

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1741214738 119 GAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIalmFGGEDGWRYAVGLTGVLSVIFGIIWYL 193
Cdd:cd17319   286 GAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYL---VDATGSYTAAFLFLAAVALLAALLVLL 357
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 230-426 5.78e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.16  E-value: 5.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 230 PMYGALALLTWKLSPTganlisanFVLAVYAFLVLLYIYEVYKTFDVNGHIFKEPVPESHRYEFKQVAVLNILYFTTFGS 309
Cdd:cd17478   136 PLIAAALVALFGGLGL--------LILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLR 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 310 ELAVVSM---LPLFFMDVFaLDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLVdaswPL 386
Cdd:cd17478   208 SWVLSSLttfLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT----PG 282

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1741214738 387 WLAVVAAMACSFFVQAGEGAVFAAVPLIKRRLTGQIAGMT 426
Cdd:cd17478   283 IWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLM 322
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 47-189 6.57e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.82  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  47 LGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVY--AALLISCSIPCFMFAMATTFEQAAIARFALGFIGAGFV- 123
Cdd:cd17316   208 LGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLviGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWg 287

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1741214738 124 VGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFGGEDGWRYAVGLTGVLSVIFGI 189
Cdd:cd17316   288 ALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 40-394 7.50e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.79  E-value: 7.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  40 LGAIAGSLGITMAQVKTLL---ILNVALTIParvVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG 116
Cdd:cd17503    19 LPTIMGDLGASLDTVQWVItsyLLALAIMIP---LSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 117 FIGAG-FVVGIRMVSEWFPANELGIAEGIYGgwgnfgsaAAAMLLPIIALMFGG----EDGWRYavgltgvlsvifgiIW 191
Cdd:cd17503    96 FGGGVlIPLAQTILLRIYPPEKRGAAMGLVG--------LVILLAPAIGPTLGGwltdNLSWRW--------------IF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 192 YLNVTdtpkggtyfkpkkvgamevtskgdFVLLLIMKIPMygalalltwklsptganlisanfvlavyaflvllyiyevy 271
Cdd:cd17503   154 YINLP------------------------IGILALLLAPL---------------------------------------- 169

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 272 ktfdVNGHIFKEPVpeshryefkqVAVLNILYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGG 351
Cdd:cd17503   170 ----LDLRLFKDRN----------FTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVG 235

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1741214738 352 WISDKLGRRITLIVLTMGLAVGYFVMGLVDASWPLWLAVVAAM 394
Cdd:cd17503   236 RLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLF 278
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
304-468 8.14e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 304 FTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLVdAS 383
Cdd:COG0738    17 FFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA-PS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 384 WPLWLAVVAAMACSF-FVQAgegAVFAAVPLIKRRLTGQIAGMTGAYGNVGAVV------YLTALSLVDYQTFFFIIAGS 456
Cdd:COG0738    96 YPLLLLALFLLGLGLgLLDV---AANPYVAALGPETAASRLNLLHAFFSLGALLgpllggLLILLGLSLSWHLPYLILAV 172

                         170
                  ....*....|..
gi 1741214738 457 ALLGLAALFFMT 468
Cdd:COG0738   173 LLLLLALLFLRS 184
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 47-193 8.85e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.41  E-value: 8.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  47 LGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGF-IGAGFVVG 125
Cdd:cd17325   230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLgLGLVFPAT 309

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1741214738 126 IRMVSEWFPANELGIAEGIYGGWGNFGSAAAamllPIIALMFGGEDGWRYAVGLTGVLSVIFGIIWYL 193
Cdd:cd17325   310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLG----PLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 37-261 1.01e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.39  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  37 APLLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALG 116
Cdd:cd17478    16 PALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 117 FIGAGF-VVGIRMVSEWFPANElGIAEGIYGGWGNFGSAAAAMLLPIIALMFGGEDGWRYAVGltGVLSVIFGIIWYLNV 195
Cdd:cd17478    96 IGSAAFhPEGARLASQAAGGRR-GLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLII--PGLAVALLLLRLRPL 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1741214738 196 TDTPKGGTYFKPKKVGAMEVTSKGDFVLLLIM---KIPMYGALALLTWKLSPTGANLISANFVLAVYAF 261
Cdd:cd17478   173 KKPEAKKAAAKSSARSTLKGVWRALLLLLIIVflrSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLF 241
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 40-186 1.08e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.19  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  40 LGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGF-I 118
Cdd:TIGR00895  40 APAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgL 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1741214738 119 GAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVI 186
Cdd:TIGR00895 120 GGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF----GWRSLFYVGGIAPLL 183
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
290-467 1.67e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.62  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 290 RYEFKQVAVLNILYFTTFGSELAVVSMLPlFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMG 369
Cdd:COG2271     6 RYRWRILALLFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 370 LAVGYFVMGLVDASWplwlavvAAMACSFFVQAGEGAVFAAVPLI-----KRRLTGQIAGMTGAYGNVGAVVYLTALSLV 444
Cdd:COG2271    85 WGLATLLFGFATSFW-------QLLLLRFLLGLGEAGFFPAALKLiaewfPPKERGRALGIFNAGGPLGGALAPPLLGWL 157

                         170       180
                  ....*....|....*....|....*..
gi 1741214738 445 ----DYQTFFFIIAGSALLGLAALFFM 467
Cdd:COG2271   158 laafGWRAAFLILGLPGLLLALLRFWL 184
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 302-470 2.18e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.49  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 302 LYFTTFGSELAVVSMLPLFFMDVFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLVD 381
Cdd:cd06174     3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 382 ASWPLWLA-VVAAMACSFFVQAGEGAVFAAVPLIKRRLTGQIAGMTGAYGNVGAVV---YLTALSLVDYQTFFFIIAGSA 457
Cdd:cd06174    83 SFWLLLLGrFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLlggILASSLGFGWRAVFLIAAALA 162

                         170
                  ....*....|...
gi 1741214738 458 LLGLAALFFMTEP 470
Cdd:cd06174   163 LLAAILLLLVVPD 175
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 70-193 2.62e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 39.85  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  70 VVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAI--ARFALGFI-GAGFVVGIRMVSEWFPANELGIAEGIYG 146
Cdd:cd17380    52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLilSRILLGLGeGVHFPSMTSLFSRWVPVSERSRAVSIVT 131

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1741214738 147 GWGNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIFGIIWYL 193
Cdd:cd17380   132 AGSYLGTLLGGLIGPLLLEYY----GWPSVFYFFGLLGLLWALVWLI 174
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
47-156 2.75e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  47 LGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGF-IGAGFVVG 125
Cdd:COG2814   238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFgFGLLFPLL 317

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1741214738 126 IRMVSEWFPANELGIAEGIYGGWGNFGSAAA 156
Cdd:COG2814   318 QALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 331-389 2.81e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.93  E-value: 2.81e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1741214738 331 YAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLVDASWPLWLA 389
Cdd:cd17388    39 HYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLG 97
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 37-190 3.32e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.87  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  37 APLLGAIAGSLGITMAQVK---TLLILNVALTIParvVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARF 113
Cdd:cd17504    16 SPALPTIQREFGTSAAAVSwvlTAYLLVGAVSTP---ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1741214738 114 ALGFIGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIFGII 190
Cdd:cd17504    93 LQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHL----GWRWIFWTAAPVAVLLAAL 165
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 39-193 3.53e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 39.46  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  39 LLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRI--VYAALLISCSIPCFMFAMATTFEQAAIARFALG 116
Cdd:cd17352   205 YLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRlyLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFG 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 117 FIGAGFVVGIRMV-SEWFPANELGIAEGIYggwgnFGSAAAAMLL--PIIALMFGGEDGWRYAVGLTGVLSVIFGIIWYL 193
Cdd:cd17352   285 FCSGSYSSLTPVIlADLVGLEKLSNAYGLV-----LLFQGLAALVgpPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFL 359
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 333-483 3.70e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.49  E-value: 3.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 333 GILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLVDASWPLWLAVVAAMACSFF---VQAGEGAVFA 409
Cdd:cd17335    35 GILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLVILGAFFSapvVPLVDSITLQ 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1741214738 410 AVPLI-----KRRLTGQIAGMTGAYGnVGAVVYLTAlSLVDYQTFFFIIAGSALLGLAALFFMTEPDGHITEVNEDGTV 483
Cdd:cd17335   115 YLGEErerygKQRLWGSIGFGIAALL-VGILIDRSS-TYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNENTGGL 191
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 39-186 3.93e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.43  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  39 LLGAIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVY---AALLISCSIPCFMFAMATTFEQAAIARFAL 115
Cdd:cd17369   251 ALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYlagALLAALFAFPFFWLLDTGSTWLIVLAAVVV 330

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1741214738 116 GFIGAGFVVGIR--MVSEWFPANELgiaegiYGGWG---NFGSAAAAMLLPIIA-LMFGGEDGWRYAVGLTGVLSVI 186
Cdd:cd17369   331 LGVLHGMMYGPQaaFLAELFPTRVR------YTGASlgyQLGAILGGGFAPLIAtALVAATGSWWPVALYLAALAVI 401
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 70-193 4.59e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 39.14  E-value: 4.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  70 VVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAA--IARFALGFI-GAGFVVGIRMVSEWFPANELGIAEGIYG 146
Cdd:cd17318    74 IPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGAliVLRILQGLAqGVTFPAMHALWAKWAPPLERSRLTSIAY 153

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1741214738 147 GWGNFGSAAAAMLLPIIALMFggedGWRYAVGLTGVLSVIFGIIWYL 193
Cdd:cd17318   154 SGSQFGTVIAMPLSGFLCESL----GWPSIFYIFGGLGLLWCLLWFF 196
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 304-466 5.98e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.07  E-value: 5.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 304 FTTFGSELAVVSMLPLFFMDvFALDMVYAGILASAYAFMNLASRPGGGWISDKLGRRITLIVLTMGLAVGYFVMGLVDAS 383
Cdd:cd17324     9 FAIGTTEYVIQGLLPDIARD-FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 384 WPLWLA-VVAAMACSFFVQAgeGAVFAAVPLIKRRLTGQIAGMTGAY--GNVGAVVYLTALS-LVDYQTFFFIIAGSALL 459
Cdd:cd17324    88 ALLLLArALAGLAHGGFWAI--AAAYAADLVPPEKRGRAIGLVFSGLtlGLVLGRPLGGLLGqLLGWRAAFLAIAVLALL 165


                  ....*..
gi 1741214738 460 GLAALFF 466
Cdd:cd17324   166 AALLLWR 172
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 70-193 6.10e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 38.72  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  70 VVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTFEQAAIARFALGFIGAG-FVVGIRMVSEWFPANELGIAeGIYggw 148
Cdd:cd17317    43 LLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGiFTVGFVLGMEIVGPKYRSFV-GIL--- 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1741214738 149 GNFGSAAAAMLLPIIALMFggeDGWRYAVGLTGVLSVIFGIIWYL 193
Cdd:cd17317   119 FGLFWALGYMLLALLAYLI---RDWRWLQLAISLPGLLFLLLLWW 160
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
42-199 7.88e-03

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 38.54  E-value: 7.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738  42 AIAGSLGITMAQVKTLLILNVALTIPARVVVGMLTDKFGPRIVYAALLISCSIPCFMFAMATTfeqaaIARFAL------ 115
Cdd:PRK11663   48 EMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSS-----LWAFALlwvlna 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1741214738 116 GFIGAGFVVGIRMVSEWFPANELGIAEGIYGGWGNFGSAAAAMLLPIIALMFGgedgWRYAVGLTGVLSVIFGIIWYLNV 195
Cdd:PRK11663  123 FFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYG----WRYGMMIAGIIAIVVGLFLCWRL 198


                  ....
gi 1741214738 196 TDTP 199
Cdd:PRK11663  199 RDKP 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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