|
Name |
Accession |
Description |
Interval |
E-value |
| strep_PBP3 |
NF038273 |
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ... |
14-417 |
8.84e-127 |
|
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.
Pssm-ID: 468443 [Multi-domain] Cd Length: 407 Bit Score: 372.67 E-value: 8.84e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 14 LAVVMVLSSFTLVGTKASAaDNLGLNVKAAILVDADSGKILYEKNAKQALGIASMTKMMTEYILLDAINDGKVKWDQKYK 93
Cdd:NF038273 3 LILLLLLLLAFFLATTVSA-DDFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTPVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 94 VSDYAYKISQDRALSNVPLRADgEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKELGLKNYHFVNSTG 173
Cdd:NF038273 82 ISDYPYELTTNYEISNVPLDAR-KYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNASG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 174 LNNEQLQGMQPTGTSESDENKMPATSVARLAYHLLKDHPEVLETSSIPRKTFrAGTDdaikMDNWNFMLPGLVYHYEGVD 253
Cdd:NF038273 161 LNNSYLGDHIYPGSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADF-AGTT----IYSYNYMLKGMPYYREGVD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 254 GLKTGTTDYAGQCFTGTAKRNGTRLIAVVMHAEGNNGDrHKARFDAAKTLFDYGFGQFTTEEILPAGHVFKNqKSVAIKE 333
Cdd:NF038273 236 GLKTGTTEKAGASFVATSVENGMRVITVVLNADNADED-EYARFTATNQLLDYIYQNFEKVTLVKKGQAYKD-SKLPVID 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 334 GKEKSVKVATKDAISMMVKTSEADDYTAKLVVDKKSLNAPVKKGTVVGHVKINKKSGKDYGFIDGTSAnAKVVTTETVEK 413
Cdd:NF038273 314 GKKKTVSAVAKKDLTVIQKIGTDSKPSVKFTPKKKELTAPIKKGQVVGKATFKDKDLIGKGYLGEPPS-VELVAKKDVKK 392
|
....
gi 1752086717 414 AGFI 417
Cdd:NF038273 393 SFFL 396
|
|
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
1-418 |
1.76e-109 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 325.64 E-value: 1.76e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 1 MKKgriskilSIMLAVVMVLSSFTlvgtkASAADNLGLNVKAAILVDADSGKILYEKNAKQALGIASMTKMMTEYILLDA 80
Cdd:COG1686 1 MKK-------LLLLALLLLLAAAA-----AAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEA 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 81 INDGKVKWDQKYKVSDYAYKIsqdrALSNVPLRADGEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKE 160
Cdd:COG1686 69 LKAGKISLDDKVTVSEEAART----GGSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 161 LGLKNYHFVNSTGLNNEqlqgmqptgtsesdENKMPATSVARLAYHLLKDHPEVLETSSIPRKTFRAGtdDAIKMDNWNf 240
Cdd:COG1686 145 LGMTNTHFVNPTGLPDP--------------GHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNG--RGITLRNTN- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 241 mlpGLVYHYEGVDGLKTGTTDYAGQCFTGTAKRNGTRLIAVVMHAEGnngdrHKARFDAAKTLFDYGFgqftteeilPAG 320
Cdd:COG1686 208 ---RLLGRYPGVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAPS-----EKARFADAAKLLDYGF---------PKG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 321 hvfknqksvaikegkeksvkvatkdaismmvktseaDDYTAKLVVDKKsLNAPVKKGTVVGHVKINKKsgkdygfiDGTS 400
Cdd:COG1686 271 ------------------------------------EALKAEVVLDGP-LKAPVKKGQVVGTLVVTLD--------GKTI 305
|
410
....*....|....*...
gi 1752086717 401 ANAKVVTTETVEKAGFIS 418
Cdd:COG1686 306 AEVPLVAAEDVEKAGFFS 323
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
41-285 |
1.50e-83 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 255.77 E-value: 1.50e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 41 KAAILVDADSGKILYEKNAKQALGIASMTKMMTEYILLDAINDGKVKWDQKYKVSDYAYKISQDrALSNVPLRADGEYTI 120
Cdd:pfam00768 9 KSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP-GSSNIFLKPGSQVSV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 121 KELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKELGLKNYHFVNSTGLNNEqlqgmqptgtsesdENKMPATSV 200
Cdd:pfam00768 88 KDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAH--------------GQYSSARDM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 201 ARLAYHLLKDHPEVLETSSIPRKTFRagtddaiKMDNWNFMLPGLVYHYEG--VDGLKTGTTDYAGQCFTGTAKRNGTRL 278
Cdd:pfam00768 154 AILAKALIKDLPEELSITKEKSFTFR-------GINKINQRNRNGLLWDKTwnVDGLKTGYTNEAGYCLVASATKGGMRL 226
|
....*..
gi 1752086717 279 IAVVMHA 285
Cdd:pfam00768 227 ISVVMGA 233
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
16-320 |
3.13e-59 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 197.51 E-value: 3.13e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 16 VVMVLSSFTLVGTKASAADNL---------------GLNVKAAILVdADSGKILYEKNAKQALGIASMTKMMTEYILLDA 80
Cdd:NF038258 1 IVSLLLLSTIITPPASAAAETpveianqegyqnlseQYNPEGAIVT-TQTGQILYDYHGNKKWDPASMTKLMTMYLTLEA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 81 INDGKVKWDQKYKVSDYAYKISQDRALSNVPLRADGEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKE 160
Cdd:NF038258 80 IKKGKLSLNDKVKITSDYEKMSTLPNLSTFPLKPGQTYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 161 LGLKNYHFVNSTGLNNEQLQGMQPTGTSESDENKMPATSVARLAYHLLKDHPEVLETSSIPrktfrAGTDDAIKMDNWNF 240
Cdd:NF038258 160 LGMKHTHFTNPSGADNNLLKPYAPKKYKDETKSKSTAKDMAILSQHLIKKHPKILKYTKLT-----ADTQHGVTLYTTNL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 241 MLPGLVYHYEGVDGLKTGTTDyAGQCFTGTAKRNGTRLIAVVMHAE--GNNGDRHkARFDAAKTLFDYGFGQFTTEEILP 318
Cdd:NF038258 235 SLPGQPMSLKGTDGLKTGTSD-EGYNLALTTKRDGLRINQVIMNVGpyPSEGAKH-ARNKIANALMERAFKQYEYKKVLS 312
|
..
gi 1752086717 319 AG 320
Cdd:NF038258 313 KG 314
|
|
| PRK10001 |
PRK10001 |
serine-type D-Ala-D-Ala carboxypeptidase; |
25-418 |
3.27e-41 |
|
serine-type D-Ala-D-Ala carboxypeptidase;
Pssm-ID: 182189 [Multi-domain] Cd Length: 400 Bit Score: 150.91 E-value: 3.27e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 25 LVGTKASAADNL----GLNVKAAILVDADSGKILYEKNAKQALGIASMTKMMTEYILLDAINDGKVKWDQKYKVSDYAYK 100
Cdd:PRK10001 20 LFAPTAFAAEQTveapSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 101 ISQD--RALSNVPLRADGEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKELGLKNYHFVNSTGLNneq 178
Cdd:PRK10001 100 TGNPalRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLD--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 179 lqgmQPTGTSEsdenkmpATSVARLAYHLLKDHPEvlETSSIPRKTFragTDDAIKMDNWNFMLPGLVYHyegVDGLKTG 258
Cdd:PRK10001 177 ----APGQFST-------ARDMALLGKALIHDVPE--EYAIHKEKEF---TFNKIRQPNRNRLLWSSNLN---VDGMKTG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 259 TTDYAGQCFTGTAKRNGTRLIAVVMhaeGNNGDRhkARFDAAKTLFDYGFGQFTTEEILPAGHVFKNQKsvaIKEGKEKS 338
Cdd:PRK10001 238 TTAGAGYNLVASATQGDMRLISVVL---GAKTDR--IRFNESEKLLTWGFRFFETVTPIKPDATFVTQR---VWFGDKSE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 339 VKVATKDAISMMVKTSEADDYTAKLVVDKKSLNAPVKKGTVVGHVkinkksgkDYGFIDGTSANAKVVTTETVEKAGFIS 418
Cdd:PRK10001 310 VNLGAGEAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTI--------DFQLNGKSIEQRPLIVMENVEEGGFFS 381
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
311-413 |
5.92e-16 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 72.63 E-value: 5.92e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 311 FTTEEILPAGHVFKnqkSVAIKEGKEKSVKVATKDAISMMVKTSEADDYTAKLVVDKKSLNAPVKKGTVVGHVKInKKSG 390
Cdd:smart00936 1 FETVKLYKKGQVVG---TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVV-TLDG 76
|
90 100
....*....|....*....|...
gi 1752086717 391 KDYGFIDgtsanakVVTTETVEK 413
Cdd:smart00936 77 KLIGEVP-------LVALEDVEK 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| strep_PBP3 |
NF038273 |
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ... |
14-417 |
8.84e-127 |
|
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.
Pssm-ID: 468443 [Multi-domain] Cd Length: 407 Bit Score: 372.67 E-value: 8.84e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 14 LAVVMVLSSFTLVGTKASAaDNLGLNVKAAILVDADSGKILYEKNAKQALGIASMTKMMTEYILLDAINDGKVKWDQKYK 93
Cdd:NF038273 3 LILLLLLLLAFFLATTVSA-DDFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTPVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 94 VSDYAYKISQDRALSNVPLRADgEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKELGLKNYHFVNSTG 173
Cdd:NF038273 82 ISDYPYELTTNYEISNVPLDAR-KYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNASG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 174 LNNEQLQGMQPTGTSESDENKMPATSVARLAYHLLKDHPEVLETSSIPRKTFrAGTDdaikMDNWNFMLPGLVYHYEGVD 253
Cdd:NF038273 161 LNNSYLGDHIYPGSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADF-AGTT----IYSYNYMLKGMPYYREGVD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 254 GLKTGTTDYAGQCFTGTAKRNGTRLIAVVMHAEGNNGDrHKARFDAAKTLFDYGFGQFTTEEILPAGHVFKNqKSVAIKE 333
Cdd:NF038273 236 GLKTGTTEKAGASFVATSVENGMRVITVVLNADNADED-EYARFTATNQLLDYIYQNFEKVTLVKKGQAYKD-SKLPVID 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 334 GKEKSVKVATKDAISMMVKTSEADDYTAKLVVDKKSLNAPVKKGTVVGHVKINKKSGKDYGFIDGTSAnAKVVTTETVEK 413
Cdd:NF038273 314 GKKKTVSAVAKKDLTVIQKIGTDSKPSVKFTPKKKELTAPIKKGQVVGKATFKDKDLIGKGYLGEPPS-VELVAKKDVKK 392
|
....
gi 1752086717 414 AGFI 417
Cdd:NF038273 393 SFFL 396
|
|
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
1-418 |
1.76e-109 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 325.64 E-value: 1.76e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 1 MKKgriskilSIMLAVVMVLSSFTlvgtkASAADNLGLNVKAAILVDADSGKILYEKNAKQALGIASMTKMMTEYILLDA 80
Cdd:COG1686 1 MKK-------LLLLALLLLLAAAA-----AAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEA 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 81 INDGKVKWDQKYKVSDYAYKIsqdrALSNVPLRADGEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKE 160
Cdd:COG1686 69 LKAGKISLDDKVTVSEEAART----GGSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 161 LGLKNYHFVNSTGLNNEqlqgmqptgtsesdENKMPATSVARLAYHLLKDHPEVLETSSIPRKTFRAGtdDAIKMDNWNf 240
Cdd:COG1686 145 LGMTNTHFVNPTGLPDP--------------GHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNG--RGITLRNTN- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 241 mlpGLVYHYEGVDGLKTGTTDYAGQCFTGTAKRNGTRLIAVVMHAEGnngdrHKARFDAAKTLFDYGFgqftteeilPAG 320
Cdd:COG1686 208 ---RLLGRYPGVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAPS-----EKARFADAAKLLDYGF---------PKG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 321 hvfknqksvaikegkeksvkvatkdaismmvktseaDDYTAKLVVDKKsLNAPVKKGTVVGHVKINKKsgkdygfiDGTS 400
Cdd:COG1686 271 ------------------------------------EALKAEVVLDGP-LKAPVKKGQVVGTLVVTLD--------GKTI 305
|
410
....*....|....*...
gi 1752086717 401 ANAKVVTTETVEKAGFIS 418
Cdd:COG1686 306 AEVPLVAAEDVEKAGFFS 323
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
41-285 |
1.50e-83 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 255.77 E-value: 1.50e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 41 KAAILVDADSGKILYEKNAKQALGIASMTKMMTEYILLDAINDGKVKWDQKYKVSDYAYKISQDrALSNVPLRADGEYTI 120
Cdd:pfam00768 9 KSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP-GSSNIFLKPGSQVSV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 121 KELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKELGLKNYHFVNSTGLNNEqlqgmqptgtsesdENKMPATSV 200
Cdd:pfam00768 88 KDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAH--------------GQYSSARDM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 201 ARLAYHLLKDHPEVLETSSIPRKTFRagtddaiKMDNWNFMLPGLVYHYEG--VDGLKTGTTDYAGQCFTGTAKRNGTRL 278
Cdd:pfam00768 154 AILAKALIKDLPEELSITKEKSFTFR-------GINKINQRNRNGLLWDKTwnVDGLKTGYTNEAGYCLVASATKGGMRL 226
|
....*..
gi 1752086717 279 IAVVMHA 285
Cdd:pfam00768 227 ISVVMGA 233
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
16-320 |
3.13e-59 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 197.51 E-value: 3.13e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 16 VVMVLSSFTLVGTKASAADNL---------------GLNVKAAILVdADSGKILYEKNAKQALGIASMTKMMTEYILLDA 80
Cdd:NF038258 1 IVSLLLLSTIITPPASAAAETpveianqegyqnlseQYNPEGAIVT-TQTGQILYDYHGNKKWDPASMTKLMTMYLTLEA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 81 INDGKVKWDQKYKVSDYAYKISQDRALSNVPLRADGEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKE 160
Cdd:NF038258 80 IKKGKLSLNDKVKITSDYEKMSTLPNLSTFPLKPGQTYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 161 LGLKNYHFVNSTGLNNEQLQGMQPTGTSESDENKMPATSVARLAYHLLKDHPEVLETSSIPrktfrAGTDDAIKMDNWNF 240
Cdd:NF038258 160 LGMKHTHFTNPSGADNNLLKPYAPKKYKDETKSKSTAKDMAILSQHLIKKHPKILKYTKLT-----ADTQHGVTLYTTNL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 241 MLPGLVYHYEGVDGLKTGTTDyAGQCFTGTAKRNGTRLIAVVMHAE--GNNGDRHkARFDAAKTLFDYGFGQFTTEEILP 318
Cdd:NF038258 235 SLPGQPMSLKGTDGLKTGTSD-EGYNLALTTKRDGLRINQVIMNVGpyPSEGAKH-ARNKIANALMERAFKQYEYKKVLS 312
|
..
gi 1752086717 319 AG 320
Cdd:NF038258 313 KG 314
|
|
| PRK10001 |
PRK10001 |
serine-type D-Ala-D-Ala carboxypeptidase; |
25-418 |
3.27e-41 |
|
serine-type D-Ala-D-Ala carboxypeptidase;
Pssm-ID: 182189 [Multi-domain] Cd Length: 400 Bit Score: 150.91 E-value: 3.27e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 25 LVGTKASAADNL----GLNVKAAILVDADSGKILYEKNAKQALGIASMTKMMTEYILLDAINDGKVKWDQKYKVSDYAYK 100
Cdd:PRK10001 20 LFAPTAFAAEQTveapSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 101 ISQD--RALSNVPLRADGEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKELGLKNYHFVNSTGLNneq 178
Cdd:PRK10001 100 TGNPalRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLD--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 179 lqgmQPTGTSEsdenkmpATSVARLAYHLLKDHPEvlETSSIPRKTFragTDDAIKMDNWNFMLPGLVYHyegVDGLKTG 258
Cdd:PRK10001 177 ----APGQFST-------ARDMALLGKALIHDVPE--EYAIHKEKEF---TFNKIRQPNRNRLLWSSNLN---VDGMKTG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 259 TTDYAGQCFTGTAKRNGTRLIAVVMhaeGNNGDRhkARFDAAKTLFDYGFGQFTTEEILPAGHVFKNQKsvaIKEGKEKS 338
Cdd:PRK10001 238 TTAGAGYNLVASATQGDMRLISVVL---GAKTDR--IRFNESEKLLTWGFRFFETVTPIKPDATFVTQR---VWFGDKSE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 339 VKVATKDAISMMVKTSEADDYTAKLVVDKKSLNAPVKKGTVVGHVkinkksgkDYGFIDGTSANAKVVTTETVEKAGFIS 418
Cdd:PRK10001 310 VNLGAGEAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTI--------DFQLNGKSIEQRPLIVMENVEEGGFFS 381
|
|
| dacD |
PRK11397 |
serine-type D-Ala-D-Ala carboxypeptidase DacD; |
16-418 |
4.28e-38 |
|
serine-type D-Ala-D-Ala carboxypeptidase DacD;
Pssm-ID: 183117 [Multi-domain] Cd Length: 388 Bit Score: 142.27 E-value: 4.28e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 16 VVMVLSSFTLVGTKASAADNLGLNVK-------AAILVDADSGKILYEKNAKQALGIASMTKMMTEYILLDAINDGKVKW 88
Cdd:PRK11397 5 LIIAASLFAFNLSSAFAAENIPFSPQppaidagSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRITP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 89 DQKYKVSDYAYkiSQDRAL----SNVPLRADGEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKKAKELGLK 164
Cdd:PRK11397 85 DDIVTVGRDAW--AKDNPVfvgsSLMFLKEGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLHLK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 165 NYHFvnstglnnEQLQGMQPTGTSESdenkmpATSVARLAYHLLKDHPEVLETSSipRKTFragTDDAIKMDNWNFMLPG 244
Cdd:PRK11397 163 DTHF--------ETVHGLDAPGQHSS------AYDLAVLSRAIIHGEPEFYHMYS--EKSL---TWNGITQQNRNGLLWD 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 245 LVYHyegVDGLKTGTTDYAGQCFTGTAKRNGTRLIAVVMhaegnNGDRHKARFDAAKTLFDYGFGQFTTEEILPAGHVFK 324
Cdd:PRK11397 224 KTMN---VDGLKTGHTSGAGFNLIASAVDGQRRLIAVVM-----GADSAKGREEQARKLLRWGQQNFTTVQILHRGKKVG 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 325 NQKsvaIKEGKEKSVKVATKDAISMMVKTSEADDYTAKLVVDKKSLNAPVKKGTVVGHVKINKKsgkdygfiDGTSANAK 404
Cdd:PRK11397 296 TER---IWYGDKENIALGTEQDFWMVLPKAEIPHIKAKYVLDGKELEAPISAHQRVGEIELYDR--------DKQVAHWP 364
|
410
....*....|....
gi 1752086717 405 VVTTETVEKAGFIS 418
Cdd:PRK11397 365 LVTLESVGEGGMFS 378
|
|
| PRK10793 |
PRK10793 |
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional |
5-418 |
3.60e-32 |
|
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
Pssm-ID: 182736 [Multi-domain] Cd Length: 403 Bit Score: 126.12 E-value: 3.60e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 5 RISKILSIMLAVVMVLSSFtlvgtkaSAADNLGL----------NVKAAILVDADSGKILYEKNAKQALGIASMTKMMTE 74
Cdd:PRK10793 8 RIMKRLALTTALCTAFISA-------AHADDLNIktmipgvpqiDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 75 YILLDAINDGKVKWDQKYKVSDYAYKISQD--RALSNVPLRADGEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLS 152
Cdd:PRK10793 81 YVIGQAMKAGKFKETDLVTVGNDAWATGNPvfKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 153 LMKKKAKELGLKNYHFvnstglnnEQLQGMQPTGTSESdenkmpATSVARLAYHLLKDHPEvlETSSIPRKTFragTDDA 232
Cdd:PRK10793 161 LMNSYVNALGLKNTHF--------QTVHGLDADGQYSS------ARDMALIGQALIRDVPN--EYAIYKEKEF---TFNG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 233 IKMDNWNfmlpGLVYHYE-GVDGLKTGTTDYAGQCFTGTAKRNGTRLIAVVMhaegnNGDRHKARFDAAKTLFDYGFGQF 311
Cdd:PRK10793 222 IRQLNRN----GLLWDNSlNVDGIKTGHTDKAGYNLVASATEGQMRLISAVM-----GGRTFKGRETESKKLLTWGFRFF 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 312 TTEEILPAGHVFknqKSVAIKEGKEKSVKVATKDAISMMVKTSEADDYTAKLVVDKKSLNAPVKKGTVVGHVKINkksgk 391
Cdd:PRK10793 293 ETVNPLKVGKEF---ASEPVWFGDSDRASLGVDKDVYLTIPRGRMKDLKASYVLNTSELHAPLQKNQVVGTINFQ----- 364
|
410 420
....*....|....*....|....*...
gi 1752086717 392 dygfIDGTSANAK-VVTTETVEKAGFIS 418
Cdd:PRK10793 365 ----LDGKTIEQRpLVVLQEIPEGNFFG 388
|
|
| pbpG |
PRK11669 |
D-alanyl-D-alanine endopeptidase; Provisional |
7-287 |
1.56e-18 |
|
D-alanyl-D-alanine endopeptidase; Provisional
Pssm-ID: 236952 Cd Length: 306 Bit Score: 85.50 E-value: 1.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 7 SKILSIMLAVVMVLSSFTLVGTKASA-------ADNLGLNVKAAILVDADSGKILYEKNAKQALGIASMTKMMTEYILLD 79
Cdd:PRK11669 1 MKFRVSLLSLLLLLAGVPFAPQAVAKtaaattaSQPQEIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMVVLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 80 AindgKVKWDQKYKVsdyayKISQDRALSNV--PLRADGEYTIKELYEAMAIYSANAATIAIAETIAGSETEFLSLMKKK 157
Cdd:PRK11669 81 A----KLPLDEKLKV-----DISQTPEMKGVysRVRLNSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNAK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 158 AKELGLKNYHFVnstglnneqlqgmQPTGTSESDenkmpaTSVARLAYHLL---KDHPEVLETSSIPRKT---------- 224
Cdd:PRK11669 152 AKALGMTNTRYV-------------EPTGLSIHN------VSTARDLTKLLiasKQYPLIGQLSTTREKTatfrkpnytl 212
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1752086717 225 -FRaGTDDAIKMDNWNFMLPglvyhyegvdglKTGTTDYAGQCFTGTAKRNGTRLIAVVMHAEG 287
Cdd:PRK11669 213 pFR-NTNHLVYRDNWNIQLT------------KTGFTNAAGHCLVMRTVINNRPVALVVLDAFG 263
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
311-413 |
5.92e-16 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 72.63 E-value: 5.92e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 311 FTTEEILPAGHVFKnqkSVAIKEGKEKSVKVATKDAISMMVKTSEADDYTAKLVVDKKSLNAPVKKGTVVGHVKInKKSG 390
Cdd:smart00936 1 FETVKLYKKGQVVG---TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVV-TLDG 76
|
90 100
....*....|....*....|...
gi 1752086717 391 KDYGFIDgtsanakVVTTETVEK 413
Cdd:smart00936 77 KLIGEVP-------LVALEDVEK 92
|
|
| PBP5_C |
pfam07943 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
311-413 |
5.94e-13 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 429749 [Multi-domain] Cd Length: 91 Bit Score: 64.15 E-value: 5.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 311 FTTEEILPAGHVFKNQKsvaIKEGKEKSVKVATKDAISMMVKTSEADDYTAKLVVdKKSLNAPVKKGTVVGHVKInKKSG 390
Cdd:pfam07943 1 FETKKLYKKGDVVKKVK---VWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVTL-KKPLEAPIKKGQVVGKLEV-YLDG 75
|
90 100
....*....|....*....|...
gi 1752086717 391 KDYGFIDgtsanakVVTTETVEK 413
Cdd:pfam07943 76 KLIGEVP-------LVAKEDVEE 91
|
|
| PenP |
COG2367 |
Beta-lactamase class A [Defense mechanisms]; |
45-306 |
7.15e-06 |
|
Beta-lactamase class A [Defense mechanisms];
Pssm-ID: 441934 [Multi-domain] Cd Length: 276 Bit Score: 47.20 E-value: 7.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 45 LVDADSGKiLYEKNAKQALGIASMTKMMTEYILLDAINDGKVKWDQKYKVSDyaykisQDRAL-SNV--PLRADGEYTIK 121
Cdd:COG2367 39 VLDLDTGE-TVGINADERFPAASTFKLPVLAAVLRQVDAGKLSLDERVTLTP------EDLVGgSGIlqKLPDGTGLTLR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 122 ELYEAMAIYSANAATIAIAETIAGSE-TEFLslmkkkaKELGLKNYHFVNSTGLNNEQLQGMQPTGTsesdenkmpATSV 200
Cdd:COG2367 112 ELAELMITVSDNTATNLLLRLLGPDAvNAFL-------RSLGLTDTRLDRKEPDLNELPGDGRNTTT---------PRDM 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 201 ARLAYHLLKdhPEVL--ETSSIPRKTFRAGTDDaikmdnwNFMLPGL-----VYHyegvdglKTGTTDYAgQCFTG--TA 271
Cdd:COG2367 176 ARLLAALYR--GELLspESRARLLDWLARQTGR-------DRLRAGLpegwrVAH-------KTGTGGGV-RNDVGivWP 238
|
250 260 270
....*....|....*....|....*....|....*..
gi 1752086717 272 KrNGTRLIAVVM--HAEGNNGDRHKARFDAAKTLFDY 306
Cdd:COG2367 239 P-DGKPYVLAVFtkGPDADAARAEALIAEIARAVYDY 274
|
|
| Beta-lactamase2 |
pfam13354 |
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ... |
45-189 |
1.56e-04 |
|
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.
Pssm-ID: 463854 [Multi-domain] Cd Length: 215 Bit Score: 42.65 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752086717 45 LVDADSGKiLYEKNAKQALGIASMTKMMTEYILLDAINDGKVKWDQKYKVSDyAYKISQDRALSnvPLRADGEYTIKELY 124
Cdd:pfam13354 4 VRDLDTGE-ELGINGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTA-EDKVGGSGILQ--YLPDGSQLSLRDLL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1752086717 125 EAMAIYSANAATIAIAETIAGSEteflslMKKKAKELGLKNYHFVNSTGLNNEQLQGMQPTGTSE 189
Cdd:pfam13354 80 TLMIAVSDNTATNLLIDRLGLEA------VNARLRALGLRDTRLRRKLPDLRAADKGGTNTTTAR 138
|
|
| AmpC |
COG1680 |
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms]; |
42-97 |
1.37e-03 |
|
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
Pssm-ID: 441286 [Multi-domain] Cd Length: 355 Bit Score: 40.82 E-value: 1.37e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1752086717 42 AAILVdADSGKILYEK-------NAKQALG------IASMTKMMTEYILLDAINDGKVKWDQkyKVSDY 97
Cdd:COG1680 35 AAVAV-VRDGKVVYEKaygvadlETGRPVTpdtlfrIASVTKSFTATAVLQLVEEGKLDLDD--PVSKY 100
|
|
| |
