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Conserved domains on  [gi|1752155183|ref|WP_150326442|]
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pyrimidine/purine nucleoside phosphorylase, partial [Enterobacter hormaechei]

Protein Classification

pyrimidine/purine nucleoside phosphorylase( domain architecture ID 10006942)

pyrimidine/purine nucleoside phosphorylase catalyzes the phosphorolysis of diverse nucleosides, such as uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine, yielding D-ribose 1-phosphate and the respective free bases; also catalyzes the reverse reactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
 1-98 1.21e-59

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


:

Pssm-ID: 442357  Cd Length: 99  Bit Score: 177.28  E-value: 1.21e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752155183   1 FDGVRLTTKANVYFDGKCVSHSFTLPDGTKKSVGVVLPATLTFGTAAAEIMECVGGSCEYKLDGTDEWKTSGAGDSFQVP 80
Cdd:COG3123     2 FDNVTVMKKANVYFDGKVKSRTFIFADGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVP 81

                          90
                  ....*....|....*...
gi 1752155183  81 ANSKFDIRVTEAYHYICH 98
Cdd:COG3123    82 ANSSFDLKVAEPTAYLCS 99
 
Name Accession Description Interval E-value
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
 1-98 1.21e-59

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


Pssm-ID: 442357  Cd Length: 99  Bit Score: 177.28  E-value: 1.21e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752155183   1 FDGVRLTTKANVYFDGKCVSHSFTLPDGTKKSVGVVLPATLTFGTAAAEIMECVGGSCEYKLDGTDEWKTSGAGDSFQVP 80
Cdd:COG3123     2 FDNVTVMKKANVYFDGKVKSRTFIFADGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVP 81

                          90
                  ....*....|....*...
gi 1752155183  81 ANSKFDIRVTEAYHYICH 98
Cdd:COG3123    82 ANSSFDLKVAEPTAYLCS 99
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 8-99 3.21e-57

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


Pssm-ID: 462023  Cd Length: 92  Bit Score: 171.13  E-value: 3.21e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752155183   8 TKANVYFDGKCVSHSFTLPDGTKKSVGVVLPATLTFGTAAAEIMECVGGSCEYKLDGTDEWKTSGAGDSFQVPANSKFDI 87
Cdd:pfam06865   1 KKANVYFDGKVTSRTFEFADGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                          90
                  ....*....|..
gi 1752155183  88 RVTEAYHYICHY 99
Cdd:pfam06865  81 KVKEVTDYLCSY 92
cupin_PpnP-like cd20296
pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family ...
 10-99 1.03e-48

pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family includes cupin domain proteins that are homologous to pyrimidine/purine nucleoside phosphorylase PpnP. Purine and pyrimidine nucleoside phosphorylases are key enzymes of the nucleoside salvage pathway; they catalyze the reversible phosphorolytic cleavage of the glycosidic bond of purine and pyrimidine nucleosides. Nucleoside phosphorylases are of medical interest since phosphorylases can be used in activating prodrugs; high-molecular mass purine nucleoside phosphorylases may be used in gene therapy of some solid tumors and their inhibitors could be selective immunosuppressive, anticancer, and antiparasitic agents. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380430  Cd Length: 90  Bit Score: 149.65  E-value: 1.03e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752155183  10 ANVYFDGKCVSHSFTLPDGTKKSVGVVLPATLTFGTAAAEIMECVGGSCEYKLDGTDEWKTSGAGDSFQVPANSKFDIRV 89
Cdd:cd20296     1 ANVYFDGKVKSRTVIFADGSKKTLGVMLPGEYTFGTEAPERMEIISGECRVKLPGETDWQTYSAGESFEVPANSSFKIEV 80

                          90
                  ....*....|
gi 1752155183  90 TEAYHYICHY 99
Cdd:cd20296    81 KEVTDYLCSY 90
PRK10579 PRK10579
pyrimidine/purine nucleoside phosphorylase;
9-99 4.08e-21

pyrimidine/purine nucleoside phosphorylase;


Pssm-ID: 182565  Cd Length: 94  Bit Score: 79.84  E-value: 4.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752155183   9 KANVYFDGKCVSHSFTLPDGTKKSVGVVLPATLTFGTAAAEIMECVGGSCEYKLDGTDEWKTSGAGDSFQVPANSKFDIR 88
Cdd:PRK10579    3 QSNEYFSGKVKSIGFDSSSTGRASVGVMAEGEYTFSTAEPEEMTVISGALNVLLPGATDWQVYEAGEVFNVPGHSEFHLQ 82

                          90
                  ....*....|.
gi 1752155183  89 VTEAYHYICHY 99
Cdd:PRK10579   83 VAEPTSYLCRY 93
 
Name Accession Description Interval E-value
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
 1-98 1.21e-59

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


Pssm-ID: 442357  Cd Length: 99  Bit Score: 177.28  E-value: 1.21e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752155183   1 FDGVRLTTKANVYFDGKCVSHSFTLPDGTKKSVGVVLPATLTFGTAAAEIMECVGGSCEYKLDGTDEWKTSGAGDSFQVP 80
Cdd:COG3123     2 FDNVTVMKKANVYFDGKVKSRTFIFADGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVP 81

                          90
                  ....*....|....*...
gi 1752155183  81 ANSKFDIRVTEAYHYICH 98
Cdd:COG3123    82 ANSSFDLKVAEPTAYLCS 99
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 8-99 3.21e-57

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


Pssm-ID: 462023  Cd Length: 92  Bit Score: 171.13  E-value: 3.21e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752155183   8 TKANVYFDGKCVSHSFTLPDGTKKSVGVVLPATLTFGTAAAEIMECVGGSCEYKLDGTDEWKTSGAGDSFQVPANSKFDI 87
Cdd:pfam06865   1 KKANVYFDGKVTSRTFEFADGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                          90
                  ....*....|..
gi 1752155183  88 RVTEAYHYICHY 99
Cdd:pfam06865  81 KVKEVTDYLCSY 92
cupin_PpnP-like cd20296
pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family ...
 10-99 1.03e-48

pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family includes cupin domain proteins that are homologous to pyrimidine/purine nucleoside phosphorylase PpnP. Purine and pyrimidine nucleoside phosphorylases are key enzymes of the nucleoside salvage pathway; they catalyze the reversible phosphorolytic cleavage of the glycosidic bond of purine and pyrimidine nucleosides. Nucleoside phosphorylases are of medical interest since phosphorylases can be used in activating prodrugs; high-molecular mass purine nucleoside phosphorylases may be used in gene therapy of some solid tumors and their inhibitors could be selective immunosuppressive, anticancer, and antiparasitic agents. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380430  Cd Length: 90  Bit Score: 149.65  E-value: 1.03e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752155183  10 ANVYFDGKCVSHSFTLPDGTKKSVGVVLPATLTFGTAAAEIMECVGGSCEYKLDGTDEWKTSGAGDSFQVPANSKFDIRV 89
Cdd:cd20296     1 ANVYFDGKVKSRTVIFADGSKKTLGVMLPGEYTFGTEAPERMEIISGECRVKLPGETDWQTYSAGESFEVPANSSFKIEV 80

                          90
                  ....*....|
gi 1752155183  90 TEAYHYICHY 99
Cdd:cd20296    81 KEVTDYLCSY 90
PRK10579 PRK10579
pyrimidine/purine nucleoside phosphorylase;
9-99 4.08e-21

pyrimidine/purine nucleoside phosphorylase;


Pssm-ID: 182565  Cd Length: 94  Bit Score: 79.84  E-value: 4.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752155183   9 KANVYFDGKCVSHSFTLPDGTKKSVGVVLPATLTFGTAAAEIMECVGGSCEYKLDGTDEWKTSGAGDSFQVPANSKFDIR 88
Cdd:PRK10579    3 QSNEYFSGKVKSIGFDSSSTGRASVGVMAEGEYTFSTAEPEEMTVISGALNVLLPGATDWQVYEAGEVFNVPGHSEFHLQ 82

                          90
                  ....*....|.
gi 1752155183  89 VTEAYHYICHY 99
Cdd:PRK10579   83 VAEPTSYLCRY 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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