|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
25-467 |
7.83e-54 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 185.07 E-value: 7.83e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 25 LCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGL 104
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 105 VDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGPlRNRALAIYTTCGATGYSMGLVFSGLLTE-ASWRLTMLLPAPI 183
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGER-RGRALGLWGAVVGIGAALGPLLGGLLLElFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 184 ALIALFVGLKLlprserergrggydipgavlgttsmlllvftvveapevgwgsartvlsfaavavmlaafvaverrspsp 263
Cdd:cd17321 160 GLVALLLARTF--------------------------------------------------------------------- 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 264 lirlgvlrsgpqVRAQLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMV 343
Cdd:cd17321 171 ------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 344 LGFALMVTGYVLFLRIDLDPVYAAVILPtMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAIFLAVVT 423
Cdd:cd17321 239 AGLLLTAVGLLLLALLGADSSVWLLLPG-LVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1752498382 424 AVVTANSPEQ---------GNASPQAVLDSYRPGLVVVTLIALAGLLITLTGL 467
Cdd:cd17321 318 ALLTAGLSANlgdsgvaalLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
23-464 |
1.73e-42 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 154.73 E-value: 1.73e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 23 LVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLG 102
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 103 GLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGPLRNRALAIYTTCGATGYSMGLVFSGLLTE-ASWRLTMLLPA 181
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQlAWWPWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 182 pialialfvglkllprserergrggydIPGAVLGTTSMLllvftvveapevgWGSARTVLSFAAVAVmlaafvaverrsp 261
Cdd:cd17476 161 ---------------------------ILAAIVAVAAIF-------------WTSPSFIAVLLAVFL------------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 262 splirlgvlrsgpqvraqlgaltFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARL 341
Cdd:cd17476 188 -----------------------GWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYI 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 342 MVLGFALMVTGYVLFLRIDLDPVYAAVILPTMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAIFLAV 421
Cdd:cd17476 245 MAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGI 324
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1752498382 422 VTAVVTanspeQGNASPQAVLDSYRPGLVVVTLIALAGLLITL 464
Cdd:cd17476 325 AGTVET-----SVNEDGADLLKGYRAAWYLGIGLAALGLLISV 362
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
25-464 |
1.73e-41 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 152.34 E-value: 1.73e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 25 LCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGL 104
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 105 VDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTE-ASWRLTMLLPAPI 183
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPE-KRGAAMGLVGLVILLAPAIGPTLGGWLTDnLSWRWIFYINLPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 184 ALIALFVGlkllprserergrggydipgavlgttsmlllvftvveapevgwgsartvlsfaavavmlaafvaverrspsP 263
Cdd:cd17503 160 GILALLLA-----------------------------------------------------------------------P 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 264 LIRLGVLRSGPQVRAQLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMV 343
Cdd:cd17503 169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 344 LGFALMVTGYVLFLRIDLDPVYAAVILPTMLLvGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAIFLAVVT 423
Cdd:cd17503 249 AGLLLLALGTLLLAFLTPDTSLWLIILPLFIR-GLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1752498382 424 AVVTANSPEQGNASP---------QAVLDSYRPGLVVVTLIALAGLLITL 464
Cdd:cd17503 328 TLLTNRTQFHHSRLSellaqqvqkQALIIAFNDAFLVSAILLLVGLLLAL 377
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
21-427 |
6.66e-39 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 147.53 E-value: 6.66e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 21 TLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASL 100
Cdd:TIGR00711 3 LTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 101 LGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGPlRNRALAIYTTCGATGYSMGLVFSGLLTEA-SWRLTMLL 179
Cdd:TIGR00711 83 LCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEK-RGRAMAIWGLTVLVAPALGPTLGGWIIENyHWRWIFLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 180 PAPIALIALFVGLKLLPRsERERGRGGYDIPGAVLGTTSMLLLVFTVVEAPEVGWGSARTVLSFAAVAVM-LAAFVAVER 258
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPR-DKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVaIIAFVVWEL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 259 RSPSPLIRLGVLRSGPQVRAQLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGT 338
Cdd:TIGR00711 241 TDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 339 ARLMVLGFALMVTGYVLFL-RIDLDPVYAAVILPtMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAI 417
Cdd:TIGR00711 321 RKLVTIGLILYAVGFYWRAfTFTPDTPFLAIALP-QFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSI 399
|
410
....*....|
gi 1752498382 418 FLAVVTAVVT 427
Cdd:TIGR00711 400 GTALITTILT 409
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-417 |
1.14e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 130.09 E-value: 1.14e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 15 TPRLWGTLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGV 94
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 95 FALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTEA-SW 173
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPE-RRGRALGLLGAGLGLGPALGPLLGGLLADLfGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 174 RLTMLLPAPIALIALFVGLKLLPRSERERGRGGYDIPGAVLGTTSMLLLVftvveapevgwgsartvlsfaavavmlaaf 253
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLL------------------------------ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 254 vaverrspsplirlgvlrsgpqvraqLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVI 333
Cdd:COG2814 214 --------------------------LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 334 DRFGTARLMVLGFALMVTGYVLFLRIDLdpvyAAVILPTMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQV 413
Cdd:COG2814 268 DRFGRRRLLLIGLLLLALGLLLLALAGS----LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
....
gi 1752498382 414 GGAI 417
Cdd:COG2814 344 GGPL 347
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
17-348 |
4.32e-26 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 110.97 E-value: 4.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 17 RLWGTLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFA 96
Cdd:PRK14995 3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 97 LASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGPLRNRALAIYTTCGATGYSMGLVFSGLLTEA-SWRL 175
Cdd:PRK14995 83 LASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHfYWGS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 176 TMLLPAPIALIALFVGLKLLPRsERERGRGGYDIPGAVLGTTSMLLLVFTVVEAPEVGWGSARTVLSFAAVAVMLAAFVA 255
Cdd:PRK14995 163 VFLINVPIVLVVMGLTARYVPR-QAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 256 VERRSPSPLIRLGVLRSGPQVRAQLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDR 335
Cdd:PRK14995 242 TQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSR 321
|
330
....*....|...
gi 1752498382 336 FGTARLMVLGFAL 348
Cdd:PRK14995 322 LGLRLVATGGMAL 334
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-300 |
1.13e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 106.43 E-value: 1.13e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 9 TSDGRWTPRLWGTLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVF 88
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 89 LVALGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPeGPLRNRALAIYTTCGATGYSMGLVFSGLL 168
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFP-ARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 169 TEA-SWRLTMLLPAPIALIALFVGLKLLPRSERERGRGGYDIPGAVLGTTSMLLLVFTVVEAPEVGWGSARTVLSFAAVA 247
Cdd:COG0477 162 VAAlGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1752498382 248 VMLAAFVAVERRSPSPLIRLGVLRSGPQVRAQLGALTFVGSYIGFQFLVTLYM 300
Cdd:COG0477 242 LLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
25-421 |
1.90e-25 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 106.88 E-value: 1.90e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 25 LCAAMFLDALDVSMVGVALPSIGADLGlSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGL 104
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 105 VDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFpegPLRNRALAIYTTCGATGYS--MGLVFSGLLTE-ASWRLTMLLPA 181
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLV---PPRERGKYQGYIGAVFGIAsvAGPLIGGAFTDhLSWRWCFYINL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 182 PIALIALFVGlkllprserergrggydipgavlgttsmlllvftvveapevgwgsaRTVLSfaavavmlaafvaverrsp 261
Cdd:cd17502 157 PIGGLALALL----------------------------------------------RTILL------------------- 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 262 splirlgvlrsgpqvrAQLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFG-TAR 340
Cdd:cd17502 172 ----------------SSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKP 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 341 LMVLGFALMVTGYVLFLRIDLDPVYAAVILpTMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAIFLA 420
Cdd:cd17502 236 LIVIGTILMSVGAGLLTTLTLDTSKWLLIG-YLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVA 314
|
.
gi 1752498382 421 V 421
Cdd:cd17502 315 I 315
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
25-417 |
3.31e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.81 E-value: 3.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 25 LCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGL 104
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 105 VDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTEA-SWRLTMLLPAPI 183
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPE-ERGRAMGIFSSAIGLGFLIGPLLGGLLADAlGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 184 ALIALFVGLKLLPRSERERGRGGYDIPGAVLGTTSMLLlvftvveapevgwgSARTVLSFAAVAVMLAAFVAVErrspsp 263
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLR--------------DRRLLALFLAIFVLAFAFGALE------ 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 264 lirlgvlrsgpqvraqlgaltfvgsyigfqFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMV 343
Cdd:cd17325 220 ------------------------------PFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1752498382 344 LGFALMVTGYVLFLRidldPVYAAVILPTMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAI 417
Cdd:cd17325 270 IGLLLSAVALLLLPL----ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
25-418 |
3.83e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 103.27 E-value: 3.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 25 LCAAMFLDALDVSMVGVALPS-IGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGG 103
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 104 LVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTEA-SWRLTMLLPAP 182
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 183 IALIALFVGLKLLPRSERERgrggydipgavlgttsmlllvftvveapevgwgsartvlsfaavavmlaaFVAVERRSPS 262
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKR--------------------------------------------------PKPAEEARLS 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 263 PLIRLGVLRSGPQVRAQLGALTFVGSYIGFQFLVTLYmQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLM 342
Cdd:pfam07690 190 LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1752498382 343 VLGFALMVTGYVLFLRIDLdPVYAAVILPTMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAIF 418
Cdd:pfam07690 269 LLALLLLILAALGLLLLSL-TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-472 |
1.25e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 101.87 E-value: 1.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 11 DGRWTPRLWGTLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLV 90
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 91 ALGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTE 170
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK-ERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 171 A-SWRLTMLLPAPIALIAlfvglkllprserergrggydipgavlgttsmlllvftvveapevgwgsartvlsfAAVAVM 249
Cdd:COG2271 160 AfGWRAAFLILGLPGLLL--------------------------------------------------------ALLRFW 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 250 LAAfvaverrspsplirlgvlrsgpqvraqLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKV 329
Cdd:COG2271 184 LLA---------------------------LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLG 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 330 GAVIDRFGTARLMVLGFALMVTGYVLFLRIDLDPVYAAVILptMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNT 409
Cdd:COG2271 237 GWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIAL--LFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNT 314
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1752498382 410 SVQVGGAIFLAVVTAVVTANspeqgnaspqavldSYRPGLVVVTLIALAGLLITLTGLRPRRE 472
Cdd:COG2271 315 FGFLGGALGPLLVGYLLDAT--------------GYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
22-417 |
2.15e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 98.41 E-value: 2.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 22 LLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLL 101
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 102 GGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFpEGPLRNRALAIYTTCGATGYSMGLVFSGLLTEASWRLTMLLPA 181
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLF-EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 182 PIALIALFVGLKLLPRSERErgrggyDIPGAVLGTTSMLLLVftvveapevgwgSARTVLSFAavavmlaafvaverrsp 261
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEK------AKSSSATKLRDLKKAL------------RGRGLLTFL----------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 262 splirlgvlrsgpqvraqLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVID-RFGTAR 340
Cdd:cd17474 205 ------------------VSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARR 266
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1752498382 341 LMVLGFALMVTGYVLFLridLDPVYAAVILPTmLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAI 417
Cdd:cd17474 267 ILVIGLLLYALSLLLLG---FVPSLALLLIAI-VLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAV 339
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-476 |
1.06e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.79 E-value: 1.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 19 WGTLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALA 98
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 99 SLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTEA-SWRLTM 177
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPD-RRGLALGLAAGGGNLGAAVAAFLAPLLIAAfGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 178 LLPAPIALIALFVGLKLLPRSERERGrggydipgavlgttsmlllvftvvEAPEVGWGSARTVLSFAAVAVMLAAFVAve 257
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAA------------------------AAAKASLRDQLEALRDPRFWLLSLLYFG-- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 258 rrspsplirlgvlrsgpqvraqlgaltFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFG 337
Cdd:COG2223 217 ---------------------------TFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 338 TARLMVLGFALMVTGYVLFLRIDLD-PVYAAVILPTMLLVGSGFALTFPSLNVQatngVDEHEQGMVSGLLNTSVQVGGA 416
Cdd:COG2223 270 GRRVLLIVFALMALGLLLLALALGSlWLFLVLFLLLGLALGGGNGAVFALVPDI----FPTKNAGAVYGLVGAAGGLGGF 345
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 417 IFLAVVTAVVTAnspeqgnaspqavLDSYRPGLVVVTLIALAGLLITLTGLRPRRERPSV 476
Cdd:COG2223 346 LGPLLFGALLDA-------------TGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-421 |
1.50e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 87.22 E-value: 1.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 22 LLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLL 101
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 102 GGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTEA-SWRLTMLLP 180
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPE-KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 181 APIALIALFVGLKLLPRSERERGRGgydipgavLGTTSMLLLVFTvveapevgwgSARTVLSFAAVAVMLAAFVAVErrs 260
Cdd:cd17324 160 AVLALLAALLLWRLLPSLPPKKPGS--------LGLLSSLLLLLR----------NPRLRLAYLITFLLFGGFFALY--- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 261 psplirlgvlrsgpqvraqlgaltfvgSYIGFqflvtlYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTAR 340
Cdd:cd17324 219 ---------------------------TYLAP------FLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 341 LMVLGFALMVTGYVLFLRidldPVYAAVILPTMLLVGSGFALTFPSLNVQATNgVDEHEQGMVSGLLNTSVQVGGAIFLA 420
Cdd:cd17324 266 LLIALLLLAAALLLLTLL----GPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAYNLGGALGAA 340
|
.
gi 1752498382 421 V 421
Cdd:cd17324 341 L 341
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
23-428 |
1.52e-18 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 88.45 E-value: 1.52e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 23 LVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALqWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLG 102
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 103 GLVDSGPLLIASRFIKGLSAA--FTAPAGLSIITttfpegPLRNR--ALAIYTTCGATGYSMGLVFSGLLTE---ASWRL 175
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGtqGLGAAVASELV------PNKYRglVQGVVNLVASPGSALGPLIAGALVEanaAGWRW 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 176 TMLLPAPIALIAlFVGLKLL---PRSERERGRGGY------DIPGAVLGTTSMLLLVFTVVEAPEV-GWGSARTVLSFAA 245
Cdd:cd06179 154 IFYINAIFNALA-LILLFFFyhpPPRPQLHGSSTRqklkrlDWVGLFLLIAGLVLFLLGLSWGGNPyPWSSAHVIAPLVI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 246 VAVMLAAFVAVERR-SPSPLIRLGVLRSGPQVrAQLGALTFVGSyIGFQFLVTLYMQQLLGW---SALHTALAFLPAGAL 321
Cdd:cd06179 233 GGVLLIAFGLYEWKgTKDGLLPPRLLFRGRNF-ALILIVAFVEG-MIFYSLNIFWPQQISLLfttDPLKAGLYQLPFGLG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 322 VALSATKVGAVIDRFGTAR-LMVLGFALMVTGYVLFLRIDLDPVYAAVILPTMLLVGSGFALTFPSLNVQatNGVDEHEQ 400
Cdd:cd06179 311 TLFGAILAGLLLTKIKHIKwQLVAGFVLFTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQ--LSVPPEDI 388
|
410 420
....*....|....*....|....*...
gi 1752498382 401 GMVSGLLNTSVQVGGAIFLAVVTAVVTA 428
Cdd:cd06179 389 GTASGLLGSARALGGAVGTAIFTSILSN 416
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-434 |
1.86e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 86.86 E-value: 1.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 22 LLVLCAAMFLDALDVSMVGVALPSIG-ADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASL 100
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAqHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 101 LGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFpEGPLRNRALAIYTTCGATGYSMGLVFSGLLTEASWRLTMLLP 180
Cdd:cd17473 81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF-EGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 181 ApIALIALFVGLKLLPrsERERGRGGYDIPGAVLGTTSMLLLVFTVVeapevgwgsartvlsFAAVAVMLAAFVAVerrs 260
Cdd:cd17473 160 L-LALPVLILVLLFLP--EPARKSKSAASPGAATAAALPWKRVLPIY---------------FLAFLAMLLFYVIP---- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 261 psplirlgvlrsgpqvraqlgaltfvgSYIGFqflvtlYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTAR 340
Cdd:cd17473 218 ---------------------------IQLPF------LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 341 LMVLGFALMVTGYVLflrIDLDPVYAAVILPtMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAIFLA 420
Cdd:cd17473 265 LLAIGFALMALGFLL---LALASGLWVVLLG-AILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
|
410
....*....|....
gi 1752498382 421 VVTAVVTANSPEQG 434
Cdd:cd17473 341 VLGPLVNLTGGLSG 354
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
23-464 |
5.02e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 82.63 E-value: 5.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 23 LVLCAAMFldALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLG 102
Cdd:cd17504 1 LALAALAV--MLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 103 GLVDSGPLLIASRFIKGLSAAfTAPAGLSIITTTFPEGPLRnRALAIYTTCGATGYSMGLVFSGLLTE-ASWRLTMLLPA 181
Cdd:cd17504 79 AFAPNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVP-VAQGILSATFGIGAGIGLPLGGWIVQhLGWRWIFWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 182 PIALIALFVglkllprserergrggydipgavlgttsmlllvftvveapevgwgsartvlsfaavavmlaafvaverrsp 261
Cdd:cd17504 157 PVAVLLAAL----------------------------------------------------------------------- 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 262 SPLIRLGVLRSGPQVRAQLGALTFVGSYIGFQFLVTLYMQQ----LLGWSALHTALAFLPAGALVALSATKVGAVIDRFG 337
Cdd:cd17504 166 VPLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 338 TARLMVLGFALMVTGYVLFLridLDPVYAAVILPTMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAI 417
Cdd:cd17504 246 PRRVLLIGLVISAVGLLLLA---LLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAI 322
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1752498382 418 FLAVVTAVVTANSPEQGNASPQAvLDSYRPGLVVVTLIALAGLLITL 464
Cdd:cd17504 323 GPAIAGAILTTYTVSITSGGVPT-EGAYVLAFLIGAALALAALLLSL 368
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
22-422 |
1.59e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 71.84 E-value: 1.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 22 LLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLL 101
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 102 GGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPeGPLRNRALAIYTTCGATGYSMGLVFSGLLTE-ASWRLTMLLP 180
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYS-GAELAKIFSLLMMILAIAPALAPLLGGLLLLfFGWRAIFVFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 181 APIALIALFVGLKLLPRSERERGRGgydipgavLGTTSMLLLVFTVVEAPEVgWGSArtvLSFAAVAVMLAAFVAverrs 260
Cdd:cd17320 160 ALLGLLLLLLVLLFLPETLPEEKRK--------PLLSSLLRAYKRVLKNRRF-LGYA---LALGLSFAGLFAYLA----- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 261 psplirlgvlrSGPQVraqlgaltfvgsyigfqflvtlyMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTAR 340
Cdd:cd17320 223 -----------AAPFI-----------------------YIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRR 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 341 LMVLGFALMVTGYVLFL--RIDLDPVYAAVILPtMLLVGSGFALTFPSLNVQATNGVDeHEQGMVSGLLNTSVQVGGAIF 418
Cdd:cd17320 269 LLRLGLLLLLAAALVLLlaALLGGLSLWPLVAP-LFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALA 346
|
....
gi 1752498382 419 LAVV 422
Cdd:cd17320 347 GALV 350
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-474 |
1.21e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 69.52 E-value: 1.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 1 MTSPLTSPTSDGRWTPRLWGTLLVLCAAMFldALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAAD 80
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNL--RPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 81 LLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGplRNRALAIYTTCGATGYSM 160
Cdd:COG2807 79 RFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR--VGLMTGLYTAAMGLGAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 161 GLVFSGLLTEA-SWRLTMLLPAPIALIALFVGLKLLPRSERERGRGGYDIPGAVLgttsmlllvftvveapevgWGSART 239
Cdd:COG2807 157 AAGLTVPLAAAlGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSL-------------------WRSPLA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 240 VLSFAAVAVMLAAFvaverrspsplirlgvlrsgpqvraqlgaltfvgsYIGFQFLVTLYMQQllGWSALHTALAFLPAG 319
Cdd:COG2807 218 WLLTLFFGLQSLLY-----------------------------------YAVVAWLPPILRDA--GLSAATAGLLLSLFQ 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 320 ALVALSATKVGAVIDRFGTARLMVLGF-ALMVTGYVLFLridLDPVYAAVILptMLLVGSGFALTFP-SLNVQATNGVDE 397
Cdd:COG2807 261 LAGIPGSLLVPLLADRLGDRRPLLLLLgLLGLAGLLGLL---LAPGSLPWLW--AVLLGLGQGGLFPlALTLIGLRARTP 335
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1752498382 398 HEQGMVSGLLNTSVQVGGAIFLAVVTAVVTAnspeqgnaspqavLDSYRPGLVVVTLIALAGLLITLTGLRPRRERP 474
Cdd:COG2807 336 AEAAALSGMAQSVGYLLAALGPLLVGALHDA-------------TGSWTAALLLLAALAVLMLVAGLLAGRPYVEDA 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
19-465 |
1.67e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 68.75 E-value: 1.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 19 WGTLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALA 98
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 99 SLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTEA-SWRLTM 177
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAR-ERGRATGLFNSGAPLGAAIGPPLSGWLLLLfGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 178 LLPAPIALIALFVGLKLLPRserergrggydipgavlgttsMLLLVftvveapevgwgsartvlsfaavavmlaafvave 257
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLRQ---------------------VWGLA---------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 258 rrspsplirlgvlrsgpqvraqLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTAL-AFLPAGALVALSATkVGAVIDRF 336
Cdd:cd17319 186 ----------------------LGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLlAAIPFLAGAIGMIL-GGRLSDRL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 337 GT-ARLMVLGFALMVTGYVLFLRIDLDPVYAAVILptMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGG 415
Cdd:cd17319 243 LRgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVIL--LSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG 320
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1752498382 416 AIFLAVVTAVVTANspeqgnaspqavlDSYRPGLVVVTLIALAGLLITLT 465
Cdd:cd17319 321 FVAPLLIGYLVDAT-------------GSYTAAFLFLAAVALLAALLVLL 357
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
211-487 |
6.41e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.23 E-value: 6.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 211 GAVLGTTSMLLLVFTVVEAPEVGWGSARTVLSFAAVAVMLAAFVAVERRSPSPLIRLGVLRSGPQVRAQLGALTFVGSYI 290
Cdd:COG2211 159 GGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 291 GFQF-------LVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMVLGFALMVTGYVLFLRIDLDP 363
Cdd:COG2211 239 LFFLalalvaaLLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 364 VYAAVILptMLLVGSGFALTFPSLNVQATNGVDEHEQ-------GMVSGLLNTSVQVGGAIFLAVVTAVVTANSPEQGNA 436
Cdd:COG2211 319 LWLLLVL--AALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAA 396
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1752498382 437 SPQAVLDSYRPGLVVVTLIALAGLLITLTGLRPRRERPSVVVARSAPKETE 487
Cdd:COG2211 397 QSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-422 |
1.43e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 65.91 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 25 LCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGL 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 105 VDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEgPLRNRALAIYTTCGATGYSMGLVFSGLLTE---ASWRLTMLLPA 181
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPE-RERGRALGLLQAFGSVGGILGPLLGGILASslgFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 182 PIALIALFVGLKLLPRSERERGRggydiPGAVLGTTSMLLLVFTVVEAPEVGWGSartvlsfaavavmlaafvaverrsp 261
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARA-----KNEEASSKSVLKLLKRVLKNPGLWLLL------------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 262 splirlgvlrsgpqvraqLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDR-FGTAR 340
Cdd:cd06174 210 ------------------LAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 341 LMVLGFALMVTGYVLFLRIDLDPVYAAVilptMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAIFLA 420
Cdd:cd06174 272 LLLIGLLLMALGLALLLLAPSLLLLLLL----LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPL 347
|
..
gi 1752498382 421 VV 422
Cdd:cd06174 348 LA 349
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-190 |
1.69e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 65.70 E-value: 1.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 22 LLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQ--WIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALAS 99
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQtgLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 100 LLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLT-----EASWR 174
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSK-RRGFALGLLQSGWALGALLAALVASLLIpllsgDWGWR 159
|
170
....*....|....*.
gi 1752498382 175 LTMLLPAPIALIALFV 190
Cdd:cd17316 160 ILFLIGALPALLALLL 175
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-422 |
1.88e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 65.65 E-value: 1.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 15 TPRLWGTLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGV 94
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 95 FALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEgpLRNRALAIYTTCGATGYSMGLVFSGLLTEASWR 174
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE--TAASRLNLLHAFFSLGALLGPLLGGLLILLGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 175 LTMLLPAPIALIALFVglkllprserergrggydipgavlgttsmLLLVFTVVEAPEVGWGSARTVLSFAAVAVMLaafv 254
Cdd:COG0738 161 LSWHLPYLILAVLLLL-----------------------------LALLFLRSKLPEIEEEEEEAAGSAASLKSLL---- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 255 averrsPSPLIRLGVlrsgpqvraqLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVID 334
Cdd:COG0738 208 ------KNPRLLLGG----------LAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 335 RFGTARLMVLGFALMVTGYVLFLRIDldpvYAAVILPTMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVqVG 414
Cdd:COG0738 272 RFGPVRLLRLSALLAAVGLLLALLAP----GPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VG 346
|
....*...
gi 1752498382 415 GAIFLAVV 422
Cdd:COG0738 347 GAIGPPLI 354
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
5-388 |
1.88e-11 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 65.91 E-value: 1.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 5 LTSPTSDGRWtpRLWgtllVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGR 84
Cdd:PRK10504 1 MTDLPDSVRW--QLW----IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 85 RQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGPLRNrALAIYTTCGATGYSMGLVF 164
Cdd:PRK10504 75 RNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMA-AMTFVTLPGQVGPLLGPAL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 165 SGLLTE-ASWRLTMLLPAPIALIALFVGLKLLPRSERERGRggYDIPGAVLGTTSMLLLVFTVVEAPEVGWGSARTVLSF 243
Cdd:PRK10504 154 GGLLVEyASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRR--FDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 244 AAVAVMLAAFVAVERRSPSPLIRLGVLRSGPQVRAQLGALTF-VGSYIgFQFLVTLYMQQLLGWSALHTALAFLPAGALV 322
Cdd:PRK10504 232 AVGVVALLLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGrIGSGM-LPFMTPVFLQIGLGFSPFHAGLMMIPMVLGS 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1752498382 323 ALSATKVGAVIDRFGTARLMV---LGFALMVtgyVLFLRIDLDPVYAAVILpTMLLVGSGFALTFPSLN 388
Cdd:PRK10504 311 MGMKRIVVQVVNRFGYRRVLVattLGLALVS---LLFMLVALLGWYYLLPF-VLFLQGMVNSTRFSSMN 375
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
17-200 |
1.51e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.76 E-value: 1.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 17 RLWGTLLVLCA-AMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVF 95
Cdd:TIGR00895 13 RYQWRAIILSFlIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 96 ALASLLGGLVDSGPLLIASRFIKGLSAAftapAGLSIITTTFPE-GPLRNRALAI-YTTCG-ATGYSMGLVFSGLLTEA- 171
Cdd:TIGR00895 93 SVFTLLCALATNVTQLLILRFLAGLGLG----GLMPNLNALVSEyAPKRFRGTAVgLMFCGyPIGAAVGGFLAGWLIPVf 168
|
170 180
....*....|....*....|....*....
gi 1752498382 172 SWRLTMLLPAPIALIALFVGLKLLPRSER 200
Cdd:TIGR00895 169 GWRSLFYVGGIAPLLLLLLLMRFLPESID 197
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
80-407 |
1.59e-10 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 62.65 E-value: 1.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 80 DLLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGplRNRALAIYTTCGATGYS 159
Cdd:cd17388 63 DRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQ--RARNFGLLGAAFGLGFI 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 160 MGLVFSGLLTEASWRLTMLLPAPIALIALFVGLKLLPRSERERGRGGYDIPGAvlgttsmlllvftvveAPEvgwGSART 239
Cdd:cd17388 141 AGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRA----------------NPF---GSLRW 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 240 VLSFAAVAVMLAAFVAVerrspsplirlgvlrsgpQVRAQLGALTFVgsyigfqflvtLYMQQLLGWSALHTALAFLPAG 319
Cdd:cd17388 202 LTGFPGLLGLLAVFFLI------------------QLIGQVPATTWV-----------LFTEDRFDWSPTMVGLSLAVFG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 320 ALVALS-ATKVGAVIDRFGTARLMVLGFALMVTGYVLFLRIDldpvYAAVILPTMLLVGSGfALTFPSLNVQATNGVDEH 398
Cdd:cd17388 253 LLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFAT----QGWMVFPILILLALG-GIAGPALQGLLSRQVPEN 327
|
....*....
gi 1752498382 399 EQGMVSGLL 407
Cdd:cd17388 328 EQGELQGVL 336
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-424 |
4.88e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.07 E-value: 4.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 25 LCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGL 104
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 105 VDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEgPLRNRALAIYTTCGATGYSMGLVFSGLLTEA-SWRLTMLLPAPI 183
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP-SRRGEGIGYYGLATTLAMALGPALGLFLYQHlGFAVLFIVAAVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 184 ALIALfvglkllprserergrggydipgavlgttsmlLLVFTVVEAPEVGwgsartvlsfaavavmlAAFVAVERRSPSP 263
Cdd:cd17489 160 ALLAL--------------------------------LLVFLVKDPPPVA-----------------AEEAEAGTRAFRR 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 264 LIRLGVLRSGpqvraqLGALTFVGSYIGFQFLVTLYMQQLLGWSAlhtALAFLPAGALVALSATKVGAVIDRFGTARLMV 343
Cdd:cd17489 191 LVEKKVLPPA------LILFLASIAYGAISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSGKLSDRKGPKTVII 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 344 LGFALMVTGYVLFLridlDPVYAAVILPTMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVG---GAIFLA 420
Cdd:cd17489 262 PGLLLLALGLLLLS----FAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGiglGGLLLG 337
|
....
gi 1752498382 421 VVTA 424
Cdd:cd17489 338 LVAE 341
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-190 |
1.08e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 60.28 E-value: 1.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 2 TSPLTSPTSDGRWTPRLWGTLLVLCAAMFLDALDVSMVGVALPSIGADL-GLSTSALQWIVSGYILGYGGLLLLGGRAAD 80
Cdd:cd17325 181 RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSD 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 81 LLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSM 160
Cdd:cd17325 261 RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE-GRGTAMGLFNTAFSLGMVL 339
|
170 180 190
....*....|....*....|....*....|.
gi 1752498382 161 GLVFSGLLTEA-SWRLTMLLPAPIALIALFV 190
Cdd:cd17325 340 GPLLGGFLYDAfGFATPFLAAAALLLLAAVL 370
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
22-188 |
7.49e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.21 E-value: 7.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 22 LLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLL 101
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 102 GGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEgplRNRALAIytTCGATGYSMGLVFSGLLTEA-----SWRLT 176
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPA---RRRSLAV--TLMFCGYPLGAALGGFLAAAlipafGWRSV 155
|
170
....*....|..
gi 1752498382 177 MLLPAPIALIAL 188
Cdd:cd17365 156 FLLGGVPPLILL 167
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
22-207 |
1.57e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.48 E-value: 1.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 22 LLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLL 101
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 102 GGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTEA--SWRLTMLL 179
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKE-KRTRALGVFYFAIPLGSGLGYVVGGLVAQAtgGWRWAFRV 159
|
170 180 190
....*....|....*....|....*....|.
gi 1752498382 180 PAP---IALIALFVGLKLLPRSERERGRGGY 207
Cdd:cd17328 160 TGVlgvLLAILLLLFVREPPRGAAEGGVMAK 190
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-464 |
4.43e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.87 E-value: 4.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 37 SMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRF 116
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 117 IKGLSAAFTAPAGLSIITTTFpeGPLRNRALAIYTTCGATGYSMGLVFSGLLTEASWRLTML-LPAPIALIALFVGLKLL 195
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAA--GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLiLLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 196 PRSERERGRggydipgavlgttsmlllvftvvEAPEVGWGSARTVLSFAAVAVMLAAFvaverrspsplirlgvLRSGpq 275
Cdd:cd17478 171 PLKKPEAKK-----------------------AAAKSSARSTLKGVWRALLLLLIIVF----------------LRSW-- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 276 vrAQLGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALValsatkvgaviDRFGTARLMVLGFALMVTGYVL 355
Cdd:cd17478 210 --VLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLS-----------DRFGRRRVIIASLLLAAPFLLL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 356 FLridldPVYAAVILPTMLLVGSGFALTFPSLNVQATNGVDEHeQGMVSGLLNTSVQVGGAIFLAVVTAVVTANSPEqgn 435
Cdd:cd17478 277 FL-----LTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLE--- 347
|
410 420
....*....|....*....|....*....
gi 1752498382 436 aspqavldsyrPGLVVVTLIALAGLLITL 464
Cdd:cd17478 348 -----------SVLLILALLPLLGALLAF 365
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
79-196 |
6.26e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 51.50 E-value: 6.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 79 ADLLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGPlRNRALAIYTTCGATGY 158
Cdd:TIGR00880 22 TDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE-RGVALGLMSAGIALGP 100
|
90 100 110
....*....|....*....|....*....|....*....
gi 1752498382 159 SMGLVFSGLLTEA-SWRLTMLLPAPIALIALFVGLKLLP 196
Cdd:TIGR00880 101 LLGPPLGGVLAQFlGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
77-433 |
5.25e-07 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 51.93 E-value: 5.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 77 RAADLLGRRQVFLVALGVFALASLL-GGLVDSGPLLIASRFIkglSAAFTapaGLSIITTTFPE--GPLRNRALAIYTTC 153
Cdd:cd17322 59 KLSDVFGRLELFLVSLLLYVVGTIImAASTNVQTYAAGSVFY---NAGYT---GLNLLLTLILAdfSSLKNRGFASAIPS 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 154 G---ATGYSMGLVFSGLLTEASWRL-----TMLLPA---PIALIALF--------VGLKLLPRSERERGRGGY------- 207
Cdd:cd17322 133 LpyiITTWIGGNIAQAALPNSNWRWgygmwAIILPLsslPLVLCLLYmqrkarkdGEIKELKNQETEEQTGGLsqnlvkl 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 208 ----DIPGAVLGTT--SMLLLVFTVVEAPEVGWGSARTVLSFAAVAVMLAAFVAVE-RRSPSPLIRLGVLRSgPQVRAQL 280
Cdd:cd17322 213 fwklDIFGVILLTAglGLILVPLTLAGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEaKFAKYPFLPFRLLKD-RTILAAC 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 281 G--ALTFVGSYIGFQFLVTlYMQQLLGWSALH-TALAFLPAGALVALsATKVGAVIDRFGTAR-LMVLGFALMVTGYVLF 356
Cdd:cd17322 292 LidFFYFFSYYIFSDYLYT-VLQVAVGESITSaTRITNLYSFVSTVA-GIFVGFLIRKTRRYKvLVIIGVPLYIVGMGLL 369
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1752498382 357 LRIDLDPVYAAVILPTMLLVG-SGFALTFPS-LNVQATngVDEHEQGMVSGLLNTSVQVGGAIFLAVVTAVVTANSPEQ 433
Cdd:cd17322 370 IRYRGGSGSHGGIIGALILIGiGGGLFTYPVqVSVQAS--VSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTLPKK 446
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
21-120 |
5.67e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 51.89 E-value: 5.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 21 TLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASL 100
Cdd:PRK11551 16 TIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSL 95
|
90 100
....*....|....*....|
gi 1752498382 101 LGGLVDSGPLLIASRFIKGL 120
Cdd:PRK11551 96 ATAQAWDFPSLLVARLLTGV 115
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
79-196 |
6.29e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.42 E-value: 6.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 79 ADLLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGL-SAAFTAPAGLSIITTTFPEgpLRNRALAIYTTCGATG 157
Cdd:cd17323 58 SELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFfGSSPLAIGAGTIADLFTPE--ERGKAMGVYSLGPLLG 135
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1752498382 158 YSMGLVFSGLLTEA-SWRLTMLLPAPIALIALFVGLKLLP 196
Cdd:cd17323 136 PALGPIIGGFITQSlGWRWIFWFLAIISGFCLILIFLFLP 175
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-194 |
1.35e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.38 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 31 LDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGLVDSGPL 110
Cdd:cd17371 10 LDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 111 LIASRFIKGLSAAFTAPAGLSIITTTFPEGPlRNRALAIYTTCGATGYSM-----GLVFSGLLTEASWRLTMLLPAPIAL 185
Cdd:cd17371 90 LLILRALAGLGFGGEWAAGAALMAEYVPARH-RGKALGYVQSGWAVGWLLatllaALLFPLLPPEIAWRVLFLLGALPAL 168
|
....*....
gi 1752498382 186 IALFVGLKL 194
Cdd:cd17371 169 LVLFIRRFV 177
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
36-124 |
1.64e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 50.41 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 36 VSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGLVDSGPLLIASR 115
Cdd:PRK10473 19 IDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGR 98
|
....*....
gi 1752498382 116 FIKGLSAAF 124
Cdd:PRK10473 99 FLQGIGAGC 107
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-432 |
6.45e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.38 E-value: 6.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 49 DLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPA 128
Cdd:cd17329 29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 129 GLSIITTTFPEGPlRNRALAIYTTCGATGYSMGLVFSGLLTEASWRLTMLLPAPIALIALFVGLKLLPRSERERGRGgyd 208
Cdd:cd17329 109 SEAMIADVTTPEN-RTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA--- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 209 ipgavlgttsmlllvftvvEAPEVGWGSaRTVLSFAAVAVMLAAFvaverrspsplirlgvlrsgpqvraqlgaltFVGS 288
Cdd:cd17329 185 -------------------EKTEILRGY-KIVLRDRAFLLFLLAS-------------------------------FLIS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 289 YIGFQFLVTL--YMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMVLGFALMVTGYVLFLridLDPVYA 366
Cdd:cd17329 214 LIYFQLESTLpvYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLA---FANTLA 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1752498382 367 AVILpTMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAIFLAVVTAVVTANSPE 432
Cdd:cd17329 291 VLIL-AMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPG 355
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
25-417 |
1.20e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.19 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 25 LCAAMFLDALDVSMVGVALPSIGA---DLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLL 101
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 102 GGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGplRNRALAIYTTCGATGYSMGLVFSGLL-TEASWRLTMLLP 180
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEE--RAKAFGIISAAFGLGFILGPALGGFLsTPYGYALPFLVA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 181 APIALIALFVGLKLLPRSERergrggydipgavlgttsmLLLVFtvveapevgwgsartVLSFAAVAVMLAAFVaverrs 260
Cdd:cd17330 159 AALALLNLVLVLFFLPPLRR-------------------LLLVY---------------FLIALAFAGLESVFS------ 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 261 psplirlgvlrsgpqvraqlgaltfvgsyigfqflvtLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVID-RFGTA 339
Cdd:cd17330 199 -------------------------------------LFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAkRLGER 241
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1752498382 340 RLMVLGFALMVTGYVLFLRIDLDPVYAAVilptMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAI 417
Cdd:cd17330 242 KLLRLGLLLAIIGLLLLPFASSVPLLVLA----AAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARII 315
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
22-204 |
1.73e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 46.99 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 22 LLVLCAAMfLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLL 101
Cdd:TIGR00710 8 LLLGCLSI-LGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 102 GGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGPLrNRALAIYTTCGATGYSMGLVFSGLLTE-ASWRLTMLLP 180
Cdd:TIGR00710 87 LALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEEL-SRIYSILMPVLALAPAVAPLLGGYILVwLSWHAIFAFL 165
|
170 180
....*....|....*....|....
gi 1752498382 181 APIALIALFVGLKLLPRSERERGR 204
Cdd:TIGR00710 166 SLAGILLSALIFFILPETLPYEAR 189
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
19-131 |
1.89e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 47.28 E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 19 WGTLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALA 98
Cdd:TIGR01299 166 WALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFF 245
|
90 100 110
....*....|....*....|....*....|...
gi 1752498382 99 SLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLS 131
Cdd:TIGR01299 246 AFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFS 278
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-248 |
2.23e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.40 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 25 LCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGL 104
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 105 VDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTEASWRLTMLLPA--P 182
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNE-NRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVllL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1752498382 183 IALIALFVGLKLLPRSERERGRGGYDI----PGAVLGT-----TSMLLLVFTVVEAPEVGWGSARTVLSFAAVAV 248
Cdd:cd17477 160 LALVPLLLTRRAAPEIEEAESISLRRLlriaPLALLGAfvagfLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVL 234
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
26-198 |
3.89e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 45.64 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 26 CAAMFLDALDVSMVGVALPSIGADL--GLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGG 103
Cdd:cd17315 3 ALGGLLFGYDLGVINGALLYIAKDLgfGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 104 LVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATG----YSMGLVFSglLTEASWRLTMLL 179
Cdd:cd17315 83 LAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAK-IRGALGTLNQLMITFGillaYLLGLALS--LSPPGWWRLMFA 159
|
170
....*....|....*....
gi 1752498382 180 PAPIALIALFVGLKLLPRS 198
Cdd:cd17315 160 LAAVPALLQLLLMFFLPES 178
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
41-415 |
7.00e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.06 E-value: 7.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 41 VALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGL 120
Cdd:TIGR00881 16 LAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 121 SAAFTAPAGLSIITTTFPEGPlRNRALAIYTTCG--ATGYSMGLVFSGLLTEASWRLTMLLPAPIALIALFVGLKL---- 194
Cdd:TIGR00881 96 FQGMGWPPCGRTVTKWFSRSE-RGTWVSFWNCSHnvGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLlrds 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 195 -----LPRSERERGRG-GYDIPGAVLGTTSMLLLVFTVVEAPeVGWGsartvLSFAAVAVMlaafvaverrspspLIRLG 268
Cdd:TIGR00881 175 pqscgLPPAEEMPNEEpDGDAEKKEEELTKKQIFLQYVLLNK-VLWY-----ISLGYVFVY--------------VVRTG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 269 VLRSGPqvraqlgalTFVGSYIGFQFLVTLYMQQLLGWSALhtalaflpAGALVAlsatkvGAVIDRFGTARLMVLGFAL 348
Cdd:TIGR00881 235 ILDWSP---------LYLTQEKGFSKEKASWAFTLYELGGL--------VGTLLA------GWLSDKLFNGRRGPLAVFF 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1752498382 349 M----VTGYVLFLRIDLDPVYAAVILPTMLLVGSGFALTFpslNVQATNGVDEHEQGMVSGLLNTSVQVGG 415
Cdd:TIGR00881 292 MaliiVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLI---GVIASELAPKKAAGTAAGFVGFFAYLGG 359
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
22-200 |
2.43e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 43.32 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 22 LLVLCAAM--FLDALDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALAS 99
Cdd:cd17359 1 LISLVAALggLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 100 LLGGLVDSGPLLIASRFIKGL---SAAFTAPAGLSIITTTfpegPLRNRALAIYTTCGATGYSMGLVF---------SGL 167
Cdd:cd17359 81 LGSAFSPNFTIFIIARIIGGLavgGASALVPMYIAEVAPA----EIRGRLVSLNQLMIVFGQLLAYIVnylianaggADW 156
|
170 180 190
....*....|....*....|....*....|...
gi 1752498382 168 LTEASWRLtMLLPAPIALIALFVGLKLLPRSER 200
Cdd:cd17359 157 LGAEGWRW-MLGLEAIPAILFLLGMLFIPESPR 188
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
211-464 |
2.47e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 43.36 E-value: 2.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 211 GAVLGTTSMLLLVFTVVEAPEVGWGSARTVLSFAAVAVMLAAFVA---VERRSP--------SPLIRLGVLRSGPQVRAQ 279
Cdd:cd17332 147 IGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFfgtRERVVPpeeeksklPLLKSLKALLKNRPFLIL 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 280 LGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMVLGFALMVTGYVLFLRI 359
Cdd:cd17332 227 LLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFL 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 360 DLDPVYAAVILPTMLLVGSGFALTFPSLNVQATngVDEHE-------QGMVSGLLNTSVQVGGAIFLAVVTAVV-----T 427
Cdd:cd17332 307 PPGNLVLILVLAVLAGIGYGGANLLPWAMLADV--IDYGElktgkrrEGIFYSVMTFFRKLGLALAGALVGLILslagyV 384
|
250 260 270
....*....|....*....|....*....|....*..
gi 1752498382 428 ANSPEQgnasPQAVLDSYRPGLVVVTLIALAGLLITL 464
Cdd:cd17332 385 ANAAAQ----SASALNGIRLLIAVLPAVLLLLALILM 417
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
35-200 |
2.74e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 43.16 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 35 DVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGLVDSGPLLIAS 114
Cdd:cd17437 12 DIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 115 RFIKGLSAAFT-----------APAGLSIITTTFPEgplrnralaIYTTCGA-TGYSMGLVFSGLLTEASWRLtMLLPAP 182
Cdd:cd17437 92 RFVAGIGVGFAlmiapvytaevAPASSRGFLTSFPE---------IFINIGIlLGYVSNYAFSGLPLHVGWRL-MLGVGA 161
|
170
....*....|....*...
gi 1752498382 183 IALIALFVGLKLLPRSER 200
Cdd:cd17437 162 VPSLFLAIGVLAMPESPR 179
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
79-204 |
3.67e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 42.72 E-value: 3.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 79 ADLLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEgPLRNRALAIYTTCGATGY 158
Cdd:cd17362 63 IDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPS-HIRGLLVSLKELFIVLGI 141
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1752498382 159 SMGLVFSGLLTEA--SWRLTMLLPAPIALIaLFVGLKLLPRSERERGR 204
Cdd:cd17362 142 LLGYVSGYAFADVvgGWRYMYGLAAPPALL-LGIGMWFLPPSPRWQGN 188
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
13-194 |
4.79e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 4.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 13 RWTPRLWGTLLVLCAAMFLdaldVSMVGVALPSIGAD-LGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVA 91
Cdd:cd06173 205 RRSPLLRLLLLALALFALL----GGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 92 LGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEgPLRNRALAIYTTCGATGYSMGLVFSGLLTEA 171
Cdd:cd06173 281 ALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPD-ELRGRVFSVYNALNSGAMPLGALLAGLLADA 359
|
170 180
....*....|....*....|....
gi 1752498382 172 -SWRLTMLLPAPIALIALFVGLKL 194
Cdd:cd06173 360 lGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
30-200 |
5.20e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 42.26 E-value: 5.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 30 FLDALDVSMVGVALPSIGADLG---LSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGLVD 106
Cdd:cd17360 7 FLFGYDTGVISGALLYIKDDLGevvLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 107 SGPLLIASRFIKGLS---AAFTAPAGLSIITTTfpegPLRNRALAIYT---TCGA-TGYSMGLVFSGLltEASWRLtMLL 179
Cdd:cd17360 87 NKEVLIVGRVLVGLGvgiASMTVPLYIAEAAPP----RIRGRLVTINVlfiTGGQfVAYVINGAFSYL--PGGWRW-MLG 159
|
170 180
....*....|....*....|.
gi 1752498382 180 PAPIALIALFVGLKLLPRSER 200
Cdd:cd17360 160 LAAVPAVLQFIGLLFLPESPR 180
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-192 |
6.76e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 6.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 14 WTPRLWGTLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQWIVSgyILGYGGLLLLGGRAADLLGRRQVFLVALG 93
Cdd:cd17489 188 FRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVY--AIALLLSRPFSGKLSDRKGPKTVIIPGLL 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 94 VFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMGLVFSGLLTEA-S 172
Cdd:cd17489 266 LLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH-RRGAANGTFFIFFDLGIGLGGLLLGLVAELfG 344
|
170 180
....*....|....*....|
gi 1752498382 173 WRLTMLLPAPIALIALFVGL 192
Cdd:cd17489 345 YRAMFLLAAVVVLLALVLYI 364
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
34-123 |
7.45e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.82 E-value: 7.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 34 LDVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGLVDSGPLLIA 113
Cdd:PRK11102 5 LAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIY 84
|
90
....*....|
gi 1752498382 114 SRFIKGLSAA 123
Cdd:PRK11102 85 MRFLHGLAAA 94
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
300-492 |
1.30e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.10 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 300 MQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMVLGFALMVTGYVLFLridLDPVYAAVILPTMLLVGSG 379
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLA---LATSLWQLYLLWGLLGGGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 380 FALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAIFLAVVTAVVTAnspeqgnaspqavlDSYRPGLVVVTLIALAG 459
Cdd:cd17355 106 AGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEA--------------FGWRTALLVLALLALLV 171
|
170 180 190
....*....|....*....|....*....|...
gi 1752498382 460 LLITLTGLRPRRERPSVVVARSAPKETERVTVR 492
Cdd:cd17355 172 LVPVLLLLRRRPADLALRAYDDASPASPGSTLK 204
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
20-464 |
1.43e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 20 GTLLVLCAAMFldaldVSMVGVALPSIGADLGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALAS 99
Cdd:cd17475 1 ATLAQAAASLV-----AQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 100 LLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYSMG-LVFSGLLTEASWRLTML 178
Cdd:cd17475 76 LLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPR-ERGLAMGIRQTGVPLGGALAaALLPPLALHYGWRAAFV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 179 LPAPIALIALFVGLKLLPRSERERGRGgydipgavlgttsmlllvftvvEAPEVGWGSARTVLSFAAVAVMLAAfvaver 258
Cdd:cd17475 155 VAGLVSILAAVLFWLFYREPPAASAAT----------------------ESASTLLRSLKEVLRNRDVWLIAIA------ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 259 rspsplirlGVLRSGPQVraqlgaltfvgsyiGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDR-FG 337
Cdd:cd17475 207 ---------GALLVAPQF--------------ALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvFG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 338 TARLMVLGFALMVTGYVLFLRIDLDPVYAAVILPTMLLVGSGFALTFPSLN-VQATNGVDEHEQGMVSGLLNTSVQVGGA 416
Cdd:cd17475 264 GRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYlTLVAESAGPEQAGTALGLANTINFIGIA 343
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1752498382 417 IFLAVVTAVVTAnspeqgnaspqavLDSYRPGLVVVTLIALAGLLITL 464
Cdd:cd17475 344 IGPPLFGLLVDA-------------THSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
13-153 |
2.15e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 13 RWTPRLWGTLLVLCAAMFLDALDVSMVGVALPSIGADLGLSTSALQ-WIVSGYILGYGGLLLLGGRAADLLGRRQVFLVA 91
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1752498382 92 LGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGLSIITTTFPEGpLRNRALAIYTTC 153
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPE-LRGRAMGIVTSA 330
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
79-197 |
2.58e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.87 E-value: 2.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 79 ADLLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGLSAAFTAPAGlSIITTTFPEGPLRNRALAIYTTCgatgY 158
Cdd:cd17317 49 ADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVG-FVLGMEIVGPKYRSFVGILFGLF----W 123
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1752498382 159 SMGLVFSGLLTEA--SWR-LTMLLPAPIALIALFvgLKLLPR 197
Cdd:cd17317 124 ALGYMLLALLAYLirDWRwLQLAISLPGLLFLLL--LWWLPR 163
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
299-382 |
2.66e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 40.18 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 299 YMQQLlGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMVLGFALMVTGYVLFLRIDLDPVYAAVILPTMLLVGS 378
Cdd:cd17337 23 YLVDL-GFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFEVLFLAFGLPSHNYPLMLLTYGLRGF 101
|
....
gi 1752498382 379 GFAL 382
Cdd:cd17337 102 GYPL 105
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
280-430 |
3.82e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 280 LGALTFVGSYIGFQFLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMVLGFALMVTGYVLFLRI 359
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1752498382 360 DLDPVYAAVilptMLLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAIFLAVVTAVVTANS 430
Cdd:pfam07690 83 SSLWLLLVL----RVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
251-384 |
4.12e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.43 E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 251 AAFVAVERRSPSPLIRlgVLRSGPQ---VRAQLGALTFVGSYIGFQFLVTlYMQQLLGWSALHTALAFLPAGALVALSAT 327
Cdd:cd17369 206 RRAKEAGQVVRAPLVE--VLRRHWRallLAIGLRLAENVLFYLFTTFALS-YATQTLGVDRSTVLLAVLIASVVAAITIP 282
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1752498382 328 KVGAVIDRFGTARLMVLG-FALMVTGYVLFLRIDLDPVYAAVILpTMLLVGSGFALTF 384
Cdd:cd17369 283 LFGWLSDRVGRRPVYLAGaLLAALFAFPFFWLLDTGSTWLIVLA-AVVVLGVLHGMMY 339
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
300-484 |
4.80e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.09 E-value: 4.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 300 MQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMVLGFALMVTGYVLFLRIDldpvYAAVILPTMLLVGSG 379
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP----SVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 380 FALTFPSLNVQATNGVDEHeQGMVSGLLNTSVQVGGAIFLAVVTAVvtanspeqgnaspqAVLDSYRPGLVVVTLIALAG 459
Cdd:COG2807 120 IAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPL--------------AAALGWRGALAVWALLALLA 184
|
170 180
....*....|....*....|....*
gi 1752498382 460 LLITLTGLRPRRERPSVVVARSAPK 484
Cdd:COG2807 185 LLLWLPLLRRRPAAAAAAPAAASLR 209
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
294-417 |
5.08e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 5.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 294 FLVTLYMQQLLGWSALHTALAFLPAGALVALSATKVGAVIDRFGTARLMVLGFALMVTGYVLFLRIDLDPVYAAVIlptm 373
Cdd:cd17329 20 PFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL---- 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1752498382 374 LLVGSGFALTFPSLNVQATNGVDEHEQGMVSGLLNTSVQVGGAI 417
Cdd:cd17329 96 VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAI 139
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
87-205 |
5.67e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 38.83 E-value: 5.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 87 VFLVALGVFALASLLGglvdsgpLLIASRFIKGLSAAFTAPAGLSIITTTFPEGPLRNRALAIYTTCGATGYSMGLVFSG 166
Cdd:cd17383 69 VMFLSTAVFAFGESYA-------VLFFARSLQGVGSAFADTAGLAMIADRFTEEAERSKALGIALAFISFGCLVAPPFGG 141
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1752498382 167 LLTE-ASWRLTMLLpapIALIALFVGLKLL----PRSERERGRG 205
Cdd:cd17383 142 ILYEfAGKEVPFLI---LAFVCLLDGLLLLlvmkPVRRETRANM 182
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-168 |
6.63e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 38.73 E-value: 6.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 21 TLLVLCAAMFLDALDVSMVGVALPSIGAD-LGLSTSALQWIVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALAS 99
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1752498382 100 LLGGLVDSG--PLLIASRFIKGLSAAFTAPAGLSIITTTFPEGPLRNR------ALAIYTTCGATGYSMGLVFSGLL 168
Cdd:COG2211 309 LLLFFLGPGnlWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGrrreglYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
80-202 |
8.29e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.35 E-value: 8.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 80 DLLGRRQVFLVALGVFALASLLGGLVDSGPLLIASRFIKGLSAafTAPAGLSIITTTFPEGpLRNRALAIYTTCGATGYS 159
Cdd:cd17472 57 DRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVMALLADLTREE-NRTKAMALIGASIGIAFA 133
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1752498382 160 MGLVFSGLLTEA-SWRLTMLLPAPIALIALFVGLKLLPRSERER 202
Cdd:cd17472 134 ISMVLGPLLAAHlGVSGLFLITAILSLVSLLILLFFVPDPPKIV 177
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
47-190 |
9.88e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.40 E-value: 9.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752498382 47 GADLGLSTSALQW--IVSGYILGYGGLLLLGGRAADLLGRRQVFLVALGVFALASLLGGLVDSGP---LLIASRFIKGLS 121
Cdd:cd17357 39 GLNLSDSELDLLWslIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKspeLLIFGRFLVGIA 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1752498382 122 AAFT---APAGLSIITTTFPEGPLRnralAIYTTCGATGYSMGLVFS--GLL-TEASWRLTMLLPAPIALIALFV 190
Cdd:cd17357 119 CGLStgfVPMYLQEISPSELRGALG----SLTQIGVTLGILLGQVFGlpSVLgTETLWPYLLFFPGIPALLQLAA 189
|
|
| |
