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Conserved domains on  [gi|1757452617|ref|WP_151145996|]
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Single-stranded DNA binding protein [Haloarcula sp. CBA1131]

Protein Classification

PRK07218 family protein( domain architecture ID 11482639)

PRK07218 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07218 PRK07218
Single-stranded DNA binding protein;
1-425 0e+00

Single-stranded DNA binding protein;


:

Pssm-ID: 180890 [Multi-domain]  Cd Length: 423  Bit Score: 687.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617   1 MSLEDHAEELASDLGVDKEEVTRDLENLVNYSVPMDEAKQSLRRKYGDGSSGGdsTPSSKAINEVSTDDSNVTVTAVVLT 80
Cdd:PRK07218    2 MKLDPHAEELASDLGVDKEEVKEELENLVAYSVPIDEAKQSIRRKYGGGGSGG--TPSSKDIKELSTDDKNVTVTGRVLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617  81 SGRRSIQYNGEQHVIREGQLADETGKISYTAWDGFSgdLQPGQTVQLGNAGVREWDGQPELNLGDSTNPEVVDETLDIDY 160
Cdd:PRK07218   80 IGERSIRYQGDDHVIYEGILADETGTISYTAWKDFG--LSPGDTVTIGNAGVREWDGRPELNIGESTTVSLLDDSSLPPY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 161 EVGGRAALQDLAPGDRGITVEVQVLECEQKVIDGRDGETTILSGVLGDESGRLPFTDWEPHEEIEEGASVRLDETFVREF 240
Cdd:PRK07218  158 SIGGDKKLIDLGPGDRGVNVEARVLELEHREIDGRDGETTILSGVLADETGRLPFTDWDPLPEIEIGASIRIEDAYVREF 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 241 RGAPSVNVSEFSTVTALDRTVEVTEDAPRMSIREAVESGGLFDVELAGNVIEVRDGSGLIERCPECGRVIQNGQCRSHGA 320
Cdd:PRK07218  238 RGVPSVNVSEFTTVEALDREVSVSKDPPRLKIREAVERGGIFDVELVGNIISVRDGSGLIERCPECGRVIQKGQCRSHGA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 321 VEGEDDLRTKAILDDGTDTVTAVLDDELTARVYGGDLDDAREHARDAMDKEVVAERISDRIVGREYVVRGSLSVDEYGAN 400
Cdd:PRK07218  318 VEGEDDLRIKAILDDGTGSVTVILDRELTEIVYGGTLEDAEELAREAMDKDVVAEDIRERLVGREYRVRGNLSVDEYGAN 397

                         410       420
                  ....*....|....*....|....*
gi 1757452617 401 LTASTFTEADDDPATRAQALLQEAD 425
Cdd:PRK07218  398 LVAESFWVPDDDPAKRAVALLAEVG 422
 
Name Accession Description Interval E-value
PRK07218 PRK07218
Single-stranded DNA binding protein;
1-425 0e+00

Single-stranded DNA binding protein;


Pssm-ID: 180890 [Multi-domain]  Cd Length: 423  Bit Score: 687.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617   1 MSLEDHAEELASDLGVDKEEVTRDLENLVNYSVPMDEAKQSLRRKYGDGSSGGdsTPSSKAINEVSTDDSNVTVTAVVLT 80
Cdd:PRK07218    2 MKLDPHAEELASDLGVDKEEVKEELENLVAYSVPIDEAKQSIRRKYGGGGSGG--TPSSKDIKELSTDDKNVTVTGRVLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617  81 SGRRSIQYNGEQHVIREGQLADETGKISYTAWDGFSgdLQPGQTVQLGNAGVREWDGQPELNLGDSTNPEVVDETLDIDY 160
Cdd:PRK07218   80 IGERSIRYQGDDHVIYEGILADETGTISYTAWKDFG--LSPGDTVTIGNAGVREWDGRPELNIGESTTVSLLDDSSLPPY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 161 EVGGRAALQDLAPGDRGITVEVQVLECEQKVIDGRDGETTILSGVLGDESGRLPFTDWEPHEEIEEGASVRLDETFVREF 240
Cdd:PRK07218  158 SIGGDKKLIDLGPGDRGVNVEARVLELEHREIDGRDGETTILSGVLADETGRLPFTDWDPLPEIEIGASIRIEDAYVREF 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 241 RGAPSVNVSEFSTVTALDRTVEVTEDAPRMSIREAVESGGLFDVELAGNVIEVRDGSGLIERCPECGRVIQNGQCRSHGA 320
Cdd:PRK07218  238 RGVPSVNVSEFTTVEALDREVSVSKDPPRLKIREAVERGGIFDVELVGNIISVRDGSGLIERCPECGRVIQKGQCRSHGA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 321 VEGEDDLRTKAILDDGTDTVTAVLDDELTARVYGGDLDDAREHARDAMDKEVVAERISDRIVGREYVVRGSLSVDEYGAN 400
Cdd:PRK07218  318 VEGEDDLRIKAILDDGTGSVTVILDRELTEIVYGGTLEDAEELAREAMDKDVVAEDIRERLVGREYRVRGNLSVDEYGAN 397

                         410       420
                  ....*....|....*....|....*
gi 1757452617 401 LTASTFTEADDDPATRAQALLQEAD 425
Cdd:PRK07218  398 LVAESFWVPDDDPAKRAVALLAEVG 422
RFA1 COG1599
ssDNA-binding replication factor A, large subunit [Replication, recombination and repair];
168-425 1.10e-89

ssDNA-binding replication factor A, large subunit [Replication, recombination and repair];


Pssm-ID: 441207 [Multi-domain]  Cd Length: 282  Bit Score: 273.09  E-value: 1.10e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 168 LQDLAPGDRGITVEVQVLEC-EQKVIDGRDG-ETTILSGVLGDESGRLPFTDWEPHE--EIEEGASVRLDETFVREFRGA 243
Cdd:COG1599    24 ISDLSPGDRDVNVEGRVLEIgEERTFDRKDGsEGRVQSGVIGDETGRIRFTLWDDKAdlELEEGDVVRIENAYVREFNGG 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 244 PSVNVSEFSTVTALDRTVEVTEDAPRMSIREAVESGGlfdVELAGNVIEVRDGSGLIERCPECGRVIQN-GQCRSHGAVE 322
Cdd:COG1599   104 PELNLGERTTIEKLDEDVEVIPDEERTPIGDIEPGGT---VSVTGTIVSVRPGSGFIKRCPECNRVLQDdGQCREHGKVR 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 323 GEDDLRTKAILDDGTDTVTAVLDDELTARVYGGDLDDAREHARDAMDKEVVAERISDRIVGREYVVRGSLSvDEYGanLT 402
Cdd:COG1599   181 GEYDLRIKAVLDDGTGTIRVVLWGELTEELYGIDLGDAIEIADDALDQGVVAEEIREKLLGRYYRVRGNLS-DRYG--LL 257

                         250       260
                  ....*....|....*....|...
gi 1757452617 403 ASTFTEADDDPATRAQALLQEAD 425
Cdd:COG1599   258 ADSIELSADDPAERAEELLAEVE 280
SoSSB_OBF cd04491
SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus ...
 73-147 1.92e-12

SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB can substitute for the basal transcription factor TBP, stimulating transcription from promoters under conditions in which TBP is limiting, and supporting transcription when TBP is absent. SSoSSB selectively melts the duplex DNA of promoter sequences. It also relieves transcriptional repression by the chromatin Alba. In addition, SSoSSB activates reverse gyrase activity, which involves DNA binding, DNA cleavage, strand passage and ligation. SSoSSB stimulates all these steps in the presence of the chromatin protein, Sul7d. SSoSSB antagonizes the inhibitory effect of Sul7d on reverse gyrase supercoiling activity. It also physically and functionally interacts with Mini-chromosome Maintenance (MCM), stimulating the DNA helicase activity of MCM.


Pssm-ID: 239937 [Multi-domain]  Cd Length: 82  Bit Score: 62.64  E-value: 1.92e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1757452617  73 TVTAVVL-TSGRRSIQYNGEQHVIREGQLADETGKISYTAWDG-FSGDLQPGQTVQLGNAGVREWDGQPELNLGDST 147
Cdd:cd04491     1 SVEGKVLsISEPREFTRDGSEGKVQSGLVGDETGTIRFTLWDEkAADDLEPGDVVRIENAYVREFNGRLELSVGKNS 77
 
Name Accession Description Interval E-value
PRK07218 PRK07218
Single-stranded DNA binding protein;
1-425 0e+00

Single-stranded DNA binding protein;


Pssm-ID: 180890 [Multi-domain]  Cd Length: 423  Bit Score: 687.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617   1 MSLEDHAEELASDLGVDKEEVTRDLENLVNYSVPMDEAKQSLRRKYGDGSSGGdsTPSSKAINEVSTDDSNVTVTAVVLT 80
Cdd:PRK07218    2 MKLDPHAEELASDLGVDKEEVKEELENLVAYSVPIDEAKQSIRRKYGGGGSGG--TPSSKDIKELSTDDKNVTVTGRVLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617  81 SGRRSIQYNGEQHVIREGQLADETGKISYTAWDGFSgdLQPGQTVQLGNAGVREWDGQPELNLGDSTNPEVVDETLDIDY 160
Cdd:PRK07218   80 IGERSIRYQGDDHVIYEGILADETGTISYTAWKDFG--LSPGDTVTIGNAGVREWDGRPELNIGESTTVSLLDDSSLPPY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 161 EVGGRAALQDLAPGDRGITVEVQVLECEQKVIDGRDGETTILSGVLGDESGRLPFTDWEPHEEIEEGASVRLDETFVREF 240
Cdd:PRK07218  158 SIGGDKKLIDLGPGDRGVNVEARVLELEHREIDGRDGETTILSGVLADETGRLPFTDWDPLPEIEIGASIRIEDAYVREF 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 241 RGAPSVNVSEFSTVTALDRTVEVTEDAPRMSIREAVESGGLFDVELAGNVIEVRDGSGLIERCPECGRVIQNGQCRSHGA 320
Cdd:PRK07218  238 RGVPSVNVSEFTTVEALDREVSVSKDPPRLKIREAVERGGIFDVELVGNIISVRDGSGLIERCPECGRVIQKGQCRSHGA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 321 VEGEDDLRTKAILDDGTDTVTAVLDDELTARVYGGDLDDAREHARDAMDKEVVAERISDRIVGREYVVRGSLSVDEYGAN 400
Cdd:PRK07218  318 VEGEDDLRIKAILDDGTGSVTVILDRELTEIVYGGTLEDAEELAREAMDKDVVAEDIRERLVGREYRVRGNLSVDEYGAN 397

                         410       420
                  ....*....|....*....|....*
gi 1757452617 401 LTASTFTEADDDPATRAQALLQEAD 425
Cdd:PRK07218  398 LVAESFWVPDDDPAKRAVALLAEVG 422
RFA1 COG1599
ssDNA-binding replication factor A, large subunit [Replication, recombination and repair];
168-425 1.10e-89

ssDNA-binding replication factor A, large subunit [Replication, recombination and repair];


Pssm-ID: 441207 [Multi-domain]  Cd Length: 282  Bit Score: 273.09  E-value: 1.10e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 168 LQDLAPGDRGITVEVQVLEC-EQKVIDGRDG-ETTILSGVLGDESGRLPFTDWEPHE--EIEEGASVRLDETFVREFRGA 243
Cdd:COG1599    24 ISDLSPGDRDVNVEGRVLEIgEERTFDRKDGsEGRVQSGVIGDETGRIRFTLWDDKAdlELEEGDVVRIENAYVREFNGG 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 244 PSVNVSEFSTVTALDRTVEVTEDAPRMSIREAVESGGlfdVELAGNVIEVRDGSGLIERCPECGRVIQN-GQCRSHGAVE 322
Cdd:COG1599   104 PELNLGERTTIEKLDEDVEVIPDEERTPIGDIEPGGT---VSVTGTIVSVRPGSGFIKRCPECNRVLQDdGQCREHGKVR 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 323 GEDDLRTKAILDDGTDTVTAVLDDELTARVYGGDLDDAREHARDAMDKEVVAERISDRIVGREYVVRGSLSvDEYGanLT 402
Cdd:COG1599   181 GEYDLRIKAVLDDGTGTIRVVLWGELTEELYGIDLGDAIEIADDALDQGVVAEEIREKLLGRYYRVRGNLS-DRYG--LL 257

                         250       260
                  ....*....|....*....|...
gi 1757452617 403 ASTFTEADDDPATRAQALLQEAD 425
Cdd:COG1599   258 ADSIELSADDPAERAEELLAEVE 280
PRK07217 PRK07217
replication factor A; Reviewed
 204-391 1.04e-44

replication factor A; Reviewed


Pssm-ID: 235970 [Multi-domain]  Cd Length: 311  Bit Score: 157.49  E-value: 1.04e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 204 GVLGDESGRLPFTDWEPHE--EIEEGASVRLDETFVREFRGAPSVNVSEFSTVTALDRTVEVTEDAprmsireavesggl 281
Cdd:PRK07217  106 GLLGDETGTIKFTKWAKSDlpELEEGKSYLLKNVVTDEYQGRFSVKLNRTTSIEELDEDIEVGDDE-------------- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 282 fdVELAGNVIEVRDGSGLIERCPE--CGRVIQNGQCRSHGAVEGEDDLRTKAILDDGTDTVTAVLDDELTARVYGGDLDD 359
Cdd:PRK07217  172 --VEVEGALVDIQSGSGLIKRCPEedCTRVLQNGRCSEHGKVEGEFDLRIKGVLDDGEEVQEVIFNREATEELTGITLEE 249

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1757452617 360 AREHARDAMDKEVVAERISDRIVGREYVVRGS 391
Cdd:PRK07217  250 AKQMAMDALDTGVVLDELKEKLLGRYYRVTGP 281
PRK06386 PRK06386
replication factor A; Reviewed
 62-423 6.03e-22

replication factor A; Reviewed


Pssm-ID: 235790 [Multi-domain]  Cd Length: 358  Bit Score: 96.51  E-value: 6.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617  62 INEVSTDDSNVTVTAVVLTSGRRSIQYNGEQHVIREGQLADETGKISYTAWDgFSGDLQPGQTVQLGNAGVREWDGQPEL 141
Cdd:PRK06386    5 ISDINAARQNVDLKVKVLSLNKRTIKNDRGETIYYYGIIGDETGTVPFTAWE-FPDAVKSGDVIEIKYCYSKEYNGKIRI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 142 NLgDSTNPEVV--DETLDIDYEVGgRAALQDLAPGDRGITVEVQVLECEQKVIDGRDGETTILSGVLGDESGRLPFTDWe 219
Cdd:PRK06386   84 YF-DSRSEVMLkpDENIEVKRTYK-LVKIRDLSLVTPYVSVIGKITGITKKEYDSDGTSKIVYQGYIEDDTARVRISSF- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 220 pHEEIEEGASVRLDETFVREFRGAPSVNVSEFSTVTALDRTVEVTEDAPRMS-IREAVesGGlfdVELAGNVIEVRDGSG 298
Cdd:PRK06386  161 -GKPLEDNRFVRIENARVSQYNGYIEISVGNKSVIKEVESDINLESRNIFIFeIKSPV--GG---ITIMGFIVSVGQGSR 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 299 LIERCPECGRVIQNGQCRSHGAVEGEDDLRTKAILDDGTDTVTAVLDDELTARVYGGDLDdarEHARDA--MDKEVVaer 376
Cdd:PRK06386  235 IFTKCSVCNKIIEDGVCKDHPDAPVYLDIFGYFTISDGTGFVTCYANKDSFLPYININEN---EFARKAssMNPNML--- 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1757452617 377 ISDRIVGREYVVRGSLSVDEYGANLTASTFTEADDDPATRAQALLQE 423
Cdd:PRK06386  309 IKKNLLGKCFSVTGDLRKKDDEIDMNVISAKSITADEIKIIEVEIEE 355
PRK12366 PRK12366
replication factor A; Reviewed
 68-396 1.74e-14

replication factor A; Reviewed


Pssm-ID: 237078 [Multi-domain]  Cd Length: 637  Bit Score: 75.47  E-value: 1.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617  68 DDSNVTVTAVVLT-SGRRSIQYNGEQHVIREGQLADETGKISYTAWDGFSG---DLQPGQTVQLGNAGVREWDG-----Q 138
Cdd:PRK12366  290 DGEEVDVKGRIIAiSDKREVERDDRTAEVQDIELADGTGRVRVSFWGEKAKileNLKEGDAVKIENCKVRTYYDnegekR 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 139 PELNLGDSTnpEVV-DETLDIDYEVGGRAALQDLAPG---DRGITVEVQVLEC----EQKVIDGRDGEttILSGVLGDES 210
Cdd:PRK12366  370 VDLNAGYSS--EIIkDESISFEEIEEKIYKIKDILNLeedDNDITVIARVVEDypvnEFERSDGSKGK--VRNIELADGT 445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 211 GRLPFTDWEPHEEIE--EGASVRLDETFVREFRGAPSVNVSEFSTVTALDRTVEVTedAPRMSIrEAVESGGLfdVELAG 288
Cdd:PRK12366  446 GSIRLTLWDDDAEIEikEGDAIKILHPYVKENGDYLDLSIGRYGRIEINPEGEIIK--SNRKFI-ADLEEDDT--VEIRG 520

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 289 NVIEVRDGSGLIERCPECGRVIQNGQ----CRSHGAVEGEDDLRTKAILDDGTDTvtavlddeLTARVYGGDLDDAREHA 364
Cdd:PRK12366  521 TVVDIRKQKIILYLCPNCRKRVEEVDgeyiCEFCGEVEPNELLMLNFTLDDGTGT--------INCRFYGKNVEKLLGMS 592

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1757452617 365 RDAMdKEVVAERISDrIVGREYVVRGSLSVDE 396
Cdd:PRK12366  593 KEEL-KELNLEALED-LLGEEVVFYGNVSFRN 622
PRK06461 PRK06461
single-stranded DNA-binding protein; Reviewed
 170-258 1.41e-12

single-stranded DNA-binding protein; Reviewed


Pssm-ID: 180574 [Multi-domain]  Cd Length: 129  Bit Score: 64.29  E-value: 1.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 170 DLAPGDRGITVEVQVLEC-EQKVIDGRDGETTILSGVLGDESGRLPFTDWEPH-EEIEEGASVRLDETFVREFRGAPSVN 247
Cdd:PRK06461    9 DLKPGMERVNVTVRVLEVgEPKVIQTKGGPRTISEAVVGDETGRVKLTLWGEQaGSLKEGEVVEIENAWTTLYRGKVQLN 88

                          90
                  ....*....|.
gi 1757452617 248 VSEFSTVTALD 258
Cdd:PRK06461   89 VGKYGSISESD 99
SoSSB_OBF cd04491
SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus ...
 73-147 1.92e-12

SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB can substitute for the basal transcription factor TBP, stimulating transcription from promoters under conditions in which TBP is limiting, and supporting transcription when TBP is absent. SSoSSB selectively melts the duplex DNA of promoter sequences. It also relieves transcriptional repression by the chromatin Alba. In addition, SSoSSB activates reverse gyrase activity, which involves DNA binding, DNA cleavage, strand passage and ligation. SSoSSB stimulates all these steps in the presence of the chromatin protein, Sul7d. SSoSSB antagonizes the inhibitory effect of Sul7d on reverse gyrase supercoiling activity. It also physically and functionally interacts with Mini-chromosome Maintenance (MCM), stimulating the DNA helicase activity of MCM.


Pssm-ID: 239937 [Multi-domain]  Cd Length: 82  Bit Score: 62.64  E-value: 1.92e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1757452617  73 TVTAVVL-TSGRRSIQYNGEQHVIREGQLADETGKISYTAWDG-FSGDLQPGQTVQLGNAGVREWDGQPELNLGDST 147
Cdd:cd04491     1 SVEGKVLsISEPREFTRDGSEGKVQSGLVGDETGTIRFTLWDEkAADDLEPGDVVRIENAYVREFNGRLELSVGKNS 77
PRK06461 PRK06461
single-stranded DNA-binding protein; Reviewed
 71-154 2.36e-12

single-stranded DNA-binding protein; Reviewed


Pssm-ID: 180574 [Multi-domain]  Cd Length: 129  Bit Score: 63.90  E-value: 2.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617  71 NVTVTAVVL-TSGRRSIQYNGEQHVIREGQLADETGKISYTAWDGFSGDLQPGQTVQLGNAGVREWDGQPELNLGDSTNP 149
Cdd:PRK06461   16 RVNVTVRVLeVGEPKVIQTKGGPRTISEAVVGDETGRVKLTLWGEQAGSLKEGEVVEIENAWTTLYRGKVQLNVGKYGSI 95


                  ....*
gi 1757452617 150 EVVDE 154
Cdd:PRK06461   96 SESDD 100
SoSSB_OBF cd04491
SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus ...
 179-257 6.28e-12

SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB can substitute for the basal transcription factor TBP, stimulating transcription from promoters under conditions in which TBP is limiting, and supporting transcription when TBP is absent. SSoSSB selectively melts the duplex DNA of promoter sequences. It also relieves transcriptional repression by the chromatin Alba. In addition, SSoSSB activates reverse gyrase activity, which involves DNA binding, DNA cleavage, strand passage and ligation. SSoSSB stimulates all these steps in the presence of the chromatin protein, Sul7d. SSoSSB antagonizes the inhibitory effect of Sul7d on reverse gyrase supercoiling activity. It also physically and functionally interacts with Mini-chromosome Maintenance (MCM), stimulating the DNA helicase activity of MCM.


Pssm-ID: 239937 [Multi-domain]  Cd Length: 82  Bit Score: 61.10  E-value: 6.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 179 TVEVQVLECEQKVIDGRDGETTIL-SGVLGDESGRLPFTDWEPH--EEIEEGASVRLDETFVREFRGAPSVNVSEFSTVT 255
Cdd:cd04491     1 SVEGKVLSISEPREFTRDGSEGKVqSGLVGDETGTIRFTLWDEKaaDDLEPGDVVRIENAYVREFNGRLELSVGKNSEIE 80


                  ..
gi 1757452617 256 AL 257
Cdd:cd04491    81 KL 82
PRK14699 PRK14699
replication factor A; Provisional
 100-362 1.43e-08

replication factor A; Provisional


Pssm-ID: 173162 [Multi-domain]  Cd Length: 484  Bit Score: 56.55  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 100 LADETGKISYTAWDGFS-----GDLQPGQTVQLGNAGVREWDGQpELNLGDSTNPEVVDETLDIdyeVGGRAALQDLAPG 174
Cdd:PRK14699  100 VGDETGKIKLTLWDNMAdlikaGKIKAGQTLQISGYAKQGYSGV-EVNIGNNGVLTESEEEIDV---AANSQKIKDIKDG 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 175 DRGITVEVQVLE-CEQKVIDGRDGETTILSGVL-GDESGRLPFTDWEPHEE----IEEGASVRLDETFVRE--FRGAPSV 246
Cdd:PRK14699  176 MGDLNLTGKVLEiSEIRTFQRKDGTSGKVGNLLlGDETGTLRVTLWDDKTDflnqIEYGDTVELINAYAREnaFTQKVEL 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 247 NVSEFSTVTALDRTVEVTEdaprmsireavESGGLFDVELAGNVIEVRdgsgliercpecGRVIQNGQCRSHGAVEGEDD 326
Cdd:PRK14699  256 QVGNRSIIRKSEKKVEYEE-----------EFTPIEDIKADMNNINIS------------GRVLDISEVRTFEKKDGSPG 312

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1757452617 327 LRTKAILDDGTDTVTAVLDDELTARVYGGDLDDARE 362
Cdd:PRK14699  313 RVGNLLLGDSTGKIRLTLWDEKTNFLDEIDFDETVE 348
PRK07211 PRK07211
single-stranded DNA binding protein;
101-293 6.69e-08

single-stranded DNA binding protein;


Pssm-ID: 180887 [Multi-domain]  Cd Length: 485  Bit Score: 54.38  E-value: 6.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 101 ADETGKISYTAWDGFS----GDLQPGQTVQLGNagvREWDGQPELNLgdSTNPEVVDETLDIDYEVGGRAALQDLAPGDR 176
Cdd:PRK07211   98 ADETGSVRVAFWDEQAvaaeEELEVGQVLRIKG---RPKDGYNGLEV--SVDKVEPDPDAEIDVQIGDTYTVEDLSLGLS 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 177 GITVEVQVLECEQ-KVIDGRDG-ETTILSGVLGDESGRLPFTDWEPH----EEIEEGASVRLDETFVREFRGAPSVNVSE 250
Cdd:PRK07211  173 DVTLVGVVLDTDSvRTFDRDDGsEGRVSNLTVGDETGRVRVTLWDDRadlaEELDAGESVEIVDGYVRERDGSLELHVGD 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1757452617 251 FSTVTALDRTVEVTEDAPRMSIREAVESgglfdVELAGNVIEV 293
Cdd:PRK07211  253 RGAVEEVDEDVEYVPDTTPIESLEIDET-----VDIAGVVRSA 290
PRK08402 PRK08402
replication factor A; Reviewed
 168-410 1.58e-05

replication factor A; Reviewed


Pssm-ID: 169427 [Multi-domain]  Cd Length: 355  Bit Score: 46.72  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 168 LQDLAPGDRGITVEVQVLEC----EQKVIDGRDGETTILsgVLGDESGRLPFTDWEP-----HEEIEEGASVRLDETFVR 238
Cdd:PRK08402   65 ISDLVPGMRGVNIVGRVLRKypprEYTKKDGSTGRVASL--IIYDDTGRARVVLWDAkvakyYNKINVGDVIKVIDAQVR 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 239 E-FRGAPSVNVSeFSTVTALDRTVEVTEDAP-----------RMSIREaVESGGLFdVELAGNVIEVRDGSgLIERCPEC 306
Cdd:PRK08402  143 EsLSGLPELHIN-FRARIILNPDDPRVEEIPpleevrsynytRKKIGE-LEGGERF-VEVRGTIAKVYRVL-VYDACPEC 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 307 GRVIQNGQ------CRSHGAVEGEDDLRTKAILDDGTDTVTAVLDDELTARVYGGDLDDAREHARDAMD-----KEV--- 372
Cdd:PRK08402  219 RRKVDYDPatdtwiCPEHGEVEPIKITILDFGLDDGTGYIRVTLFGDDAAELLGVEPEEIAEKLKELIEmgltpKEAark 298

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1757452617 373 VAERISDRIVGREYVVRGSLSVDEY-GANLTASTFTEAD 410
Cdd:PRK08402  299 LAEEEFYNIIGREIVVRGNVIEDRFlGLILKASSWDEVD 337
PRK15491 PRK15491
replication factor A; Provisional
 62-266 2.81e-04

replication factor A; Provisional


Pssm-ID: 185388 [Multi-domain]  Cd Length: 374  Bit Score: 42.95  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617  62 INEVSTDDSNVTVTA-VVLTSGRRSIQYN-GEQHVIREGQLADETGKISYTAWDGF-----SGDLQPGQTVQLGNAGVRE 134
Cdd:PRK15491   60 IADINESSSNVNFTAkVVSIFEPKEFNRNdGTTGRVGNIIVADETGSIRLTLWDDLadlikTGDIEVGKSLNISGYAKEG 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 135 WDGQpELNLGDSTNPEVVDETLDIDYEVGGRAALQDlapGDRGITVEVQVLEC-EQKVIDGRDGETTILSGVL-GDESGR 212
Cdd:PRK15491  140 YSGI-EVNIGRYGGISESDENVKASINSQKISDIKD---GDSDINIVGKVLDIsDVRTFQKKDGSQGRVRNITiGDETGK 215

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 213 LPFTDW----EPHEEIEEGASVRLDETFVR--EFRGAPSVNVSEFSTVTALDRTVEVTED 266
Cdd:PRK15491  216 IRVTLWdgktDLADKLENGDSVEIINGYARtnNYSQEVEIQIGNHGSLRKTDRNVEYEED 275
YhaM COG3481
3'-5' exoribonuclease YhaM, can participate in 23S rRNA maturation, HD superfamily ...
 168-258 3.70e-04

3'-5' exoribonuclease YhaM, can participate in 23S rRNA maturation, HD superfamily [Translation, ribosomal structure and biogenesis]; 3'-5' exoribonuclease YhaM, can participate in 23S rRNA maturation, HD superfamily is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 442704 [Multi-domain]  Cd Length: 316  Bit Score: 42.10  E-value: 3.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617 168 LQDLAPGDRgITVEVQVLECEQKVidGRDGETtILSGVLGDESGRLPFTDWEPHEE----IEEGASVRLDETfVREFRGA 243
Cdd:COG3481     7 IKDLKPGEE-VDGFFLIKSKELRT--TKNGKP-YLSLTLQDKTGTIEAKIWDASEEdieeFQPGDVVKVRGK-VQEYQGR 81

                          90
                  ....*....|....*
gi 1757452617 244 PSVNVSEFSTVTALD 258
Cdd:COG3481    82 LQLKITRIRLADEEE 96
PRK07211 PRK07211
single-stranded DNA binding protein;
62-161 4.52e-04

single-stranded DNA binding protein;


Pssm-ID: 180887 [Multi-domain]  Cd Length: 485  Bit Score: 42.44  E-value: 4.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757452617  62 INEVSTDDSNVTVTAVVLTSG--RRSIQYNGEQHVIREGQLADETGKISYTAWDG---FSGDLQPGQTVQLGNAGVREWD 136
Cdd:PRK07211  164 VEDLSLGLSDVTLVGVVLDTDsvRTFDRDDGSEGRVSNLTVGDETGRVRVTLWDDradLAEELDAGESVEIVDGYVRERD 243

                          90       100
                  ....*....|....*....|....*
gi 1757452617 137 GQPELNLGDSTNPEVVDEtlDIDYE 161
Cdd:PRK07211  244 GSLELHVGDRGAVEEVDE--DVEYV 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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