|
Name |
Accession |
Description |
Interval |
E-value |
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
23-270 |
3.45e-113 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 326.68 E-value: 3.45e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 23 CGNN----AASDGKTIKIGATAGPYYDMVKKaIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQ 98
Cdd:COG1464 20 CGSSsaaaAAADKKTIKVGATPGPHAEILEV-VKPELAKKGIDLEIVEFTDYVQPNEALADGEIDANYFQHIPYLDNFNK 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 99 ENNKNLAALISVPTVPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDtLKASVQDIAENPKK 178
Cdd:COG1464 99 ENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLKDGVG-LLATVKDITENPKN 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 179 LTFKQLESANLPRAVDDLDIAAVPGNFALSANMK-LQDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEET 257
Cdd:COG1464 178 LKFVELDAAQLPRSLDDVDAAVINGNYALEAGLDpTKDALFLEDKDSPYANIIVVREDDKDDPAIKKLVEAYQSDEVKKF 257
|
250
....*....|...
gi 1758834231 258 IDREFAGFGKPKW 270
Cdd:COG1464 258 IEEKYKGAVVPAW 270
|
|
| PBP2_lipoprotein_Gna1946 |
cd13599 |
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 ... |
33-259 |
2.49e-107 |
|
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold; Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270317 Cd Length: 228 Bit Score: 310.10 E-value: 2.49e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 33 TIKIGATAGPYYDMVKKAIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNLAALISVPT 112
Cdd:cd13599 1 TIVIGFTPGPYGDMVKNGVAPYLEKKGYEVKLKEFTDYVQPNNALANGEIDANVFQHKPYLDAFNKENGLDLVGIVQVPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 113 VPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDTLKASVQDIAENPKKLTFKQLESANLPRA 192
Cdd:cd13599 81 PPMGLYSNKHKSLEEVKDGATVAIPNDPSNLARALVMLQDLGWITLKDNIDPLKASVNDIAENPKNIKIVELEAAQLPRS 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1758834231 193 VDDLDIAAVPGNFALSANMKLQDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETID 259
Cdd:cd13599 161 LDDVDFAAIQGNFAISSGIKLTSALALEEMTDPYVNVVAVKTADKDKQFAKDVTAAYNSDAFKAYIH 227
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
34-270 |
1.75e-89 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 265.28 E-value: 1.75e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 34 IKIGATAGPYYDMVKKAiQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNLAALISVPTV 113
Cdd:pfam03180 1 LKVGATPGPHAEILEVA-KPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 114 PMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDTLkASVQDIAENPKKLTFKQLESANLPRAV 193
Cdd:pfam03180 80 PMGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDGKGLL-ATVKDITENPKNLKIKELEAAQLPRAL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1758834231 194 DDLDIAAVPGNFALSANMK-LQDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETIDREFAGFGKPKW 270
Cdd:pfam03180 159 DDVDAAVINTNYALEAGLNpKKDALFEEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPAW 236
|
|
| PRK09861 |
PRK09861 |
lipoprotein NlpA; |
25-270 |
6.77e-50 |
|
lipoprotein NlpA;
Pssm-ID: 182119 Cd Length: 272 Bit Score: 165.58 E-value: 6.77e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 25 NNAASDGKTIKIGATAGPYYDMVKKAIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNL 104
Cdd:PRK09861 25 DQSSSDAKHIKVGVINGAEQDVAEVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGELDANVFQHRPFLEQDNQAHGYKL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 105 AALISVPTVPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDTLKASVqDIAENPKKLTFKQL 184
Cdd:PRK09861 105 VAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLLPTAL-DITDNPRHLQIMEL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 185 ESANLPRAVDD--LDIAAVPGNFALSANMK-LQDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETIDRE 261
Cdd:PRK09861 184 EGAQLPRVLDDpkVDVAIISTTYIQQTGLSpVHDSVFIEDKNSPYVNILVAREDNKNAENVKEFLQSYQSPEVAKAAETI 263
|
....*....
gi 1758834231 262 FAGFGKPKW 270
Cdd:PRK09861 264 FNGGAVPGW 272
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
23-270 |
4.67e-48 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 160.45 E-value: 4.67e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 23 CGNNAaSDGKTIKIGATAGPYYDMVKKAIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNK 102
Cdd:TIGR00363 10 CKQDK-KDPLHIKVGVISGAEQQVAEVAAKVAKEKYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAKAKGY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 103 NLAALISVPTVPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKsDVDTLKASVQDIAENPKKLTFK 182
Cdd:TIGR00363 89 KLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLK-DGNGLLPTVLDIVENPKKLNIT 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 183 QLESANLPRAVDD--LDIAAVPGNFALSANMKLQ-DALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETID 259
Cdd:TIGR00363 168 ELETSQLPRALDDpkVDLAVINTTYAGQVGLNPQdDGVFVEDKDSPYVNIIVSREDNKDAENVKDFIQSYQSEEVYQAAQ 247
|
250
....*....|.
gi 1758834231 260 REFAGFGKPKW 270
Cdd:TIGR00363 248 KHFNGGAVKGW 258
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
23-270 |
3.45e-113 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 326.68 E-value: 3.45e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 23 CGNN----AASDGKTIKIGATAGPYYDMVKKaIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQ 98
Cdd:COG1464 20 CGSSsaaaAAADKKTIKVGATPGPHAEILEV-VKPELAKKGIDLEIVEFTDYVQPNEALADGEIDANYFQHIPYLDNFNK 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 99 ENNKNLAALISVPTVPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDtLKASVQDIAENPKK 178
Cdd:COG1464 99 ENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLKDGVG-LLATVKDITENPKN 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 179 LTFKQLESANLPRAVDDLDIAAVPGNFALSANMK-LQDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEET 257
Cdd:COG1464 178 LKFVELDAAQLPRSLDDVDAAVINGNYALEAGLDpTKDALFLEDKDSPYANIIVVREDDKDDPAIKKLVEAYQSDEVKKF 257
|
250
....*....|...
gi 1758834231 258 IDREFAGFGKPKW 270
Cdd:COG1464 258 IEEKYKGAVVPAW 270
|
|
| PBP2_lipoprotein_Gna1946 |
cd13599 |
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 ... |
33-259 |
2.49e-107 |
|
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold; Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270317 Cd Length: 228 Bit Score: 310.10 E-value: 2.49e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 33 TIKIGATAGPYYDMVKKAIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNLAALISVPT 112
Cdd:cd13599 1 TIVIGFTPGPYGDMVKNGVAPYLEKKGYEVKLKEFTDYVQPNNALANGEIDANVFQHKPYLDAFNKENGLDLVGIVQVPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 113 VPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDTLKASVQDIAENPKKLTFKQLESANLPRA 192
Cdd:cd13599 81 PPMGLYSNKHKSLEEVKDGATVAIPNDPSNLARALVMLQDLGWITLKDNIDPLKASVNDIAENPKNIKIVELEAAQLPRS 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1758834231 193 VDDLDIAAVPGNFALSANMKLQDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETID 259
Cdd:cd13599 161 LDDVDFAAIQGNFAISSGIKLTSALALEEMTDPYVNVVAVKTADKDKQFAKDVTAAYNSDAFKAYIH 227
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
34-270 |
1.75e-89 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 265.28 E-value: 1.75e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 34 IKIGATAGPYYDMVKKAiQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNLAALISVPTV 113
Cdd:pfam03180 1 LKVGATPGPHAEILEVA-KPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 114 PMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDTLkASVQDIAENPKKLTFKQLESANLPRAV 193
Cdd:pfam03180 80 PMGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDGKGLL-ATVKDITENPKNLKIKELEAAQLPRAL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1758834231 194 DDLDIAAVPGNFALSANMK-LQDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETIDREFAGFGKPKW 270
Cdd:pfam03180 159 DDVDAAVINTNYALEAGLNpKKDALFEEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPAW 236
|
|
| PBP2_lipoprotein_Tp32 |
cd13597 |
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ... |
33-264 |
2.87e-78 |
|
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270315 Cd Length: 236 Bit Score: 236.79 E-value: 2.87e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 33 TIKIGATAGPYYDMVKkAIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNLAALISVPT 112
Cdd:cd13597 1 TLKVGATPVPHAEILE-FIKPELKKQGIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 113 VPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDTLkASVQDIAENPKKLTFKQLESANLPRA 192
Cdd:cd13597 80 EPMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGLT-ATVKDIVKNPKNLKFKELEAAQLPRS 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1758834231 193 VDDLDIAAVPGNFALSANMK-LQDALALENMPD-RYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETIDREFAG 264
Cdd:cd13597 159 LDDVDAAVINGNYALEAGLNpKKDALALEDKDNsPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDG 232
|
|
| PBP2_lipoprotein_MetQ_like |
cd13526 |
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ... |
33-259 |
3.02e-78 |
|
The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270244 Cd Length: 228 Bit Score: 236.44 E-value: 3.02e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 33 TIKIGATAGPYYDMVKKAiQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNLAALISVPT 112
Cdd:cd13526 1 KLKIGVTAGPSADVVEAA-KKEAKKKGYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 113 VPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDtLKASVQDIAENPKKLTFKQLESANLPRA 192
Cdd:cd13526 80 APIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVG-LFATVLDITENPKNLEIVEVDAAQLPRS 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1758834231 193 VDDLDIAAVPGNFALSANMKLQ-DALALENMPD-RYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETID 259
Cdd:cd13526 159 LDDVDAAVINGNYAISAGLDPRkDAIFLEDSDAsPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLK 227
|
|
| PBP2_lipoprotein_like_1 |
cd13600 |
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ... |
33-259 |
2.41e-66 |
|
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270318 Cd Length: 228 Bit Score: 206.03 E-value: 2.41e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 33 TIKIGATAGPYYDMVKKaIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNLAALISVPT 112
Cdd:cd13600 1 TLKVATNSGPMTEILEY-IAAELAPDGITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVAVQPIYH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 113 VPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDTLKASVQDIAENPKKLTFKQLESANLPRA 192
Cdd:cd13600 80 WAFGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVDPTTATLADIVTNPKNLKFTEVDLLALPRA 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1758834231 193 VDDLDIAAV-PGNFALSANMKLQDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETID 259
Cdd:cd13600 160 LDDVDLAFGyPSYFDAAGLTPKDGILLEEPDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRVRKFLE 227
|
|
| PBP2_lipoprotein_IlpA_like |
cd13598 |
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar ... |
34-259 |
3.94e-64 |
|
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar lipoproteins; the type 2 periplasmic binding protein fold; This group includes the IlpA protein which has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270316 Cd Length: 227 Bit Score: 200.27 E-value: 3.94e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 34 IKIGATAGPYYDMVKKAIQPELEKkGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNLAALISVPTV 113
Cdd:cd13598 2 IKVGVIRGPDAQIWEVVQKVAKEK-GLDVELVTFNDYAQPNEALAAGDLDANAFQHKPYLDAQIKARGYKLVIVGNTFVY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 114 PMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVdTLKASVQDIAENPKKLTFKQLESANLPRAV 193
Cdd:cd13598 81 PIGLYSKKIKSLAELPNGATVAIPNDPSNEGRALLLLQKEGLIKLKDGV-GLLATVRDIAENPKKLKIVELDAGQLPRAL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1758834231 194 DDLDIAAVPGNFALSANMKL-QDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETID 259
Cdd:cd13598 160 DDVDLAAINTDYASKAGLTPaRDAIAQEDKRSPYANVIAVREDDKDAPWVKTLVQAYQSEEVKAFAL 226
|
|
| PBP2_lipoprotein_GmpC |
cd13596 |
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; ... |
33-256 |
5.49e-56 |
|
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; contains the type 2 periplasmic-binding protein fold; This group includes the membrane-associated lipoprotein-9 from Staphylococcus aureus that binds the dipeptide glycylmethionine (GlyMet). The lipoprotein-9 has both structural and sequential homology to the MetQ family of substrate-binding protein. The GlyMet binding protein belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270314 Cd Length: 230 Bit Score: 179.87 E-value: 5.49e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 33 TIKIGaTAGPYYDmVKKAIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNLAALISVPT 112
Cdd:cd13596 1 TVKIG-VTGEDTD-IWDKIVEEAEEAGIKLELVNFSDYSQPNKALNDGDIDLNAFQHYAYLVQYNSKNNADLTAIGDTVI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 113 VPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDTLKaSVQDIAENPKKLTFKQLESANLPRA 192
Cdd:cd13596 79 APMGIYSKKITSVDELPDGAKIAIPNDPSNLSRALFILQAAGLIKLKKDAGDFP-TVNDITENPKNLEIVPVDADQVYRA 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1758834231 193 VDDLDIAAVPGNFALSA-NMKLQDALALENmPDRYR-----NQVVVDEKNKDKPFAKDLKEAVKS----KAFEE 256
Cdd:cd13596 158 LNDVDAAVINNTFALDAgLDPKKDAIFLED-PSSYGskpyiNLIAVREEDKDNPLYKKLVETYHDervqKAVEE 230
|
|
| PRK09861 |
PRK09861 |
lipoprotein NlpA; |
25-270 |
6.77e-50 |
|
lipoprotein NlpA;
Pssm-ID: 182119 Cd Length: 272 Bit Score: 165.58 E-value: 6.77e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 25 NNAASDGKTIKIGATAGPYYDMVKKAIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNKNL 104
Cdd:PRK09861 25 DQSSSDAKHIKVGVINGAEQDVAEVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGELDANVFQHRPFLEQDNQAHGYKL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 105 AALISVPTVPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDTLKASVqDIAENPKKLTFKQL 184
Cdd:PRK09861 105 VAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLLPTAL-DITDNPRHLQIMEL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 185 ESANLPRAVDD--LDIAAVPGNFALSANMK-LQDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETIDRE 261
Cdd:PRK09861 184 EGAQLPRVLDDpkVDVAIISTTYIQQTGLSpVHDSVFIEDKNSPYVNILVAREDNKNAENVKEFLQSYQSPEVAKAAETI 263
|
....*....
gi 1758834231 262 FAGFGKPKW 270
Cdd:PRK09861 264 FNGGAVPGW 272
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
23-270 |
4.67e-48 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 160.45 E-value: 4.67e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 23 CGNNAaSDGKTIKIGATAGPYYDMVKKAIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNK 102
Cdd:TIGR00363 10 CKQDK-KDPLHIKVGVISGAEQQVAEVAAKVAKEKYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAKAKGY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 103 NLAALISVPTVPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKsDVDTLKASVQDIAENPKKLTFK 182
Cdd:TIGR00363 89 KLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLK-DGNGLLPTVLDIVENPKKLNIT 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 183 QLESANLPRAVDD--LDIAAVPGNFALSANMKLQ-DALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETID 259
Cdd:TIGR00363 168 ELETSQLPRALDDpkVDLAVINTTYAGQVGLNPQdDGVFVEDKDSPYVNIIVSREDNKDAENVKDFIQSYQSEEVYQAAQ 247
|
250
....*....|.
gi 1758834231 260 REFAGFGKPKW 270
Cdd:TIGR00363 248 KHFNGGAVKGW 258
|
|
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
23-264 |
5.95e-47 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 158.00 E-value: 5.95e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 23 CGNNAAsDGKTIKIGATAGPYYDMVKKAIQPELEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENNK 102
Cdd:PRK11063 23 CGQDEK-DPNHIKVGVIVGAEQQVAEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGDIDANAFQHKPYLDQQIKDRGY 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 103 NLAALISVPTVPMGLYSAKYNDLNDVKSGAEVAVPNDPANAARAFLTLQDQGLIRLKSDVDTLkASVQDIAENPKKLTFK 182
Cdd:PRK11063 102 KLVAVGNTFVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDGVGLL-PTVLDIVENPKNLKIV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 183 QLESANLPRAVDDLDIAAVPGNFALSANMKL---QDALALENMPDRYRNQVVVDEKNKDKPFAKDLKEAVKSKAFEETID 259
Cdd:PRK11063 181 ELEAPQLPRSLDDAQIALAVINTTYASQIGLtpaKDGIFVEDKDSPYVNLIVAREDNKDAENVKKFVQAYQSDEVYEAAN 260
|
....*
gi 1758834231 260 REFAG 264
Cdd:PRK11063 261 KVFNG 265
|
|
| TauA |
COG0715 |
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion ... |
27-209 |
2.38e-04 |
|
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion transport and metabolism];
Pssm-ID: 440479 [Multi-domain] Cd Length: 297 Bit Score: 41.91 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 27 AASDGKTIKIG----ATAGPYYDMVKKAIqpeLEKKGYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQENN- 101
Cdd:COG0715 17 AAAEKVTLRLGwlpnTDHAPLYVAKEKGY---FKKEGLDVELVEFAGGAAALEALAAGQADFGVAGAPPALAARAKGAPv 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 102 KNLAALISVPtvPMGLYSAK---YNDLNDVKsGAEVAVPndPANAARAFL--TLQDQGLirlksdvdtlkasvqdiaeNP 176
Cdd:COG0715 94 KAVAALSQSG--GNALVVRKdsgIKSLADLK-GKKVAVP--GGSTSHYLLraLLAKAGL-------------------DP 149
|
170 180 190
....*....|....*....|....*....|....*
gi 1758834231 177 KKLTFKQLESANLPRAV--DDLDIAAVPGNFALSA 209
Cdd:COG0715 150 KDVEIVNLPPPDAVAALlaGQVDAAVVWEPFESQA 184
|
|
| Periplasmic_Binding_Protein_Type_2 |
cd00648 |
Type 2 periplasmic binding fold superfamily; This evolutionary model and hierarchy represent ... |
33-147 |
7.31e-03 |
|
Type 2 periplasmic binding fold superfamily; This evolutionary model and hierarchy represent the ligand-binding domains found in solute binding proteins that serve as initial receptors in the transport, signal transduction and channel gating. The PBP2 proteins share the same architecture as periplasmic binding proteins type 1 (PBP1), but have a different topology. They are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The origin of PBP module can be traced across the distant phyla, including eukaryotes, archebacteria, and prokaryotes. The majority of PBP2 proteins are involved in the uptake of a variety of soluble substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the family includes ionotropic glutamate receptors and unorthodox sensor proteins involved in signal transduction. The substrate binding domain of the LysR transcriptional regulators and the oligopeptide-like transport systems also contain the type 2 periplasmic binding fold and thus they are significantly homologous to that of the PBP2; however, these two families are grouped into a separate hierarchy of the PBP2 superfamily due to the large number of protein sequences.
Pssm-ID: 270214 [Multi-domain] Cd Length: 196 Bit Score: 36.78 E-value: 7.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758834231 33 TIKIGATAGPYYDMVKKAIQPELEKK-GYKVEVIEFTDYVQPNTALSEGELDANLFQHEVFMKSYNQ-ENNKNLAALISV 110
Cdd:cd00648 1 TLTVASIGPPPYAGFAEDAAKQLAKEtGIKVELVPGSSIGTLIEALAAGDADVAVGPIAPALEAAADkLAPGGLYIVPEL 80
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1758834231 111 PTVPMGLYSAKYNDLNDVKS-----GAEVAVPNDPANAARAF 147
Cdd:cd00648 81 YVGGYVLVVRKGSSIKGLLAvadldGKRVGVGDPGSTAVRQA 122
|
|
| |
