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Conserved domains on  [gi|1764296852|ref|WP_151813223|]
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DDE-type integrase/transposase/recombinase, partial [Acinetobacter sp. TUM15371]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS3 super family cl41295
IS3 family transposase;
1-71 1.70e-30

IS3 family transposase;


The actual alignment was detected with superfamily member NF033516:

Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 109.19  E-value: 1.70e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1764296852   1 TVIQPNKVWTTDITYIRTKQGWLYLCVMLDLFSRRIVGWQTRHRIDRQLVCDTFNYAMARQGYPTGVMVHS 71
Cdd:NF033516  211 TATRPNQVWVTDITYIRTAEGWLYLAVVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPEGLILHS 281
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
1-71 1.70e-30

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 109.19  E-value: 1.70e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1764296852   1 TVIQPNKVWTTDITYIRTKQGWLYLCVMLDLFSRRIVGWQTRHRIDRQLVCDTFNYAMARQGYPTGVMVHS 71
Cdd:NF033516  211 TATRPNQVWVTDITYIRTAEGWLYLAVVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPEGLILHS 281
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
1-71 3.12e-27

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 99.46  E-value: 3.12e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1764296852   1 TVIQPNKVWTTDITYIRTKQGWLYLCVMLDLFSRRIVGWQTRHRIDRQLVCDTFNYAMARQGYPTGVMVHS 71
Cdd:COG2801   144 TATAPNQVWVTDITYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRGPPKPLILHS 214
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 2-71 2.87e-20

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 80.68  E-value: 2.87e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1764296852   2 VIQPNKVWTTDITYIRTKQGWLYLCVMLDLFSRRIVGWQTRHRIDRQLVCDTFNYAMARQGYPTGVMVHS 71
Cdd:PHA02517  106 ATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVLDALEQALWARGRPGGLIHHS 175
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 5-71 1.06e-18

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.06e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1764296852  5 PNKVWTTDITYIR--TKQGWLYLCVMLDLFSRRIVGWQTRHRIDRQLVCDTFNYAMARQGYPtGVMVHS 71
Cdd:pfam00665  1 PNQLWQGDFTYIRipGGGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRGGV-PLIIHS 68
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
1-71 1.70e-30

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 109.19  E-value: 1.70e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1764296852   1 TVIQPNKVWTTDITYIRTKQGWLYLCVMLDLFSRRIVGWQTRHRIDRQLVCDTFNYAMARQGYPTGVMVHS 71
Cdd:NF033516  211 TATRPNQVWVTDITYIRTAEGWLYLAVVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPEGLILHS 281
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
1-71 3.12e-27

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 99.46  E-value: 3.12e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1764296852   1 TVIQPNKVWTTDITYIRTKQGWLYLCVMLDLFSRRIVGWQTRHRIDRQLVCDTFNYAMARQGYPTGVMVHS 71
Cdd:COG2801   144 TATAPNQVWVTDITYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRGPPKPLILHS 214
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 2-71 2.87e-20

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 80.68  E-value: 2.87e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1764296852   2 VIQPNKVWTTDITYIRTKQGWLYLCVMLDLFSRRIVGWQTRHRIDRQLVCDTFNYAMARQGYPTGVMVHS 71
Cdd:PHA02517  106 ATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVLDALEQALWARGRPGGLIHHS 175
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 5-71 1.06e-18

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.06e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1764296852  5 PNKVWTTDITYIR--TKQGWLYLCVMLDLFSRRIVGWQTRHRIDRQLVCDTFNYAMARQGYPtGVMVHS 71
Cdd:pfam00665  1 PNQLWQGDFTYIRipGGGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRGGV-PLIIHS 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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