Heparan-alpha-glucosaminide N-acetyltransferase, catalytic; This entry includes the catalytic ...
41-220
2.68e-05
Heparan-alpha-glucosaminide N-acetyltransferase, catalytic; This entry includes the catalytic domain of HGSNAT (Heparan-alpha-glucosaminide N-acetyltransferase). It contains the conserved histidine in the active site (His269), thought to hold the acetyl group during the transfer across the membrane and required for its enzymatic activity. HGSNAT transfers an acetyl group from cytoplasmically derived acetyl-CoA to terminal N-glucosamine residues of heparan sulfate within the lysosomes.
Pssm-ID: 377915 Cd Length: 222 Bit Score: 45.29 E-value: 2.68e-05
Heparan-alpha-glucosaminide N-acetyltransferase, catalytic; This entry includes the catalytic ...
41-220
2.68e-05
Heparan-alpha-glucosaminide N-acetyltransferase, catalytic; This entry includes the catalytic domain of HGSNAT (Heparan-alpha-glucosaminide N-acetyltransferase). It contains the conserved histidine in the active site (His269), thought to hold the acetyl group during the transfer across the membrane and required for its enzymatic activity. HGSNAT transfers an acetyl group from cytoplasmically derived acetyl-CoA to terminal N-glucosamine residues of heparan sulfate within the lysosomes.
Pssm-ID: 377915 Cd Length: 222 Bit Score: 45.29 E-value: 2.68e-05
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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