NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1772674740|ref|WP_153252657|]
View 

MULTISPECIES: hypothetical protein [Priestia]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CdiI_EcoliA0-like cd20693
inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of ...
 28-148 2.05e-42

inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of Escherichia coli A0 34/86, and similar proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the inhibitor (CdiI, also called CdiI immunity protein) of the CdiA effector protein from Escherichia coli A0 34/86, and similar proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via its C-terminal domain (CdiA-CT). The CdiI immunity proteins are intracellular proteins that inactivate the toxin/effector protein to prevent auto-inhibition. They are specific for their cognate CdiA-CT and do not protect cells from the toxins of other CDI+ bacteria. Thus, CDI systems encode a complex network of toxin-immunity protein pairs that are deployed for intercellular competition. This E. coli CdiI binds its cognate toxin CdiA-CT domain with high affinity.


:

Pssm-ID: 412047  Cd Length: 124  Bit Score: 136.91  E-value: 2.05e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772674740  28 PLFSECVNALGKGVIIYSPEKSEERYCSFQKEVPFTFYGRIEWDKFDKYcVITYLEDVKSLIN--DDDLEIYWSTDNFPV 105
Cdd:cd20693     2 TLFEECIEALGEDFRILSDEESKEIYDKFENYFPFTSWGRIDWSKINKK-DIEIIDELLSLLNlkNEEVYIIWDDADIPV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1772674740 106 LKTKFENILSVYDDVVAVDSNTFLYIENKYVIEIYHDGEMRIG 148
Cdd:cd20693    81 IKTNLKLILENIDDVTAVSFDTWIFNPENYVIEFYHEGEITVG 123
 
Name Accession Description Interval E-value
CdiI_EcoliA0-like cd20693
inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of ...
 28-148 2.05e-42

inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of Escherichia coli A0 34/86, and similar proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the inhibitor (CdiI, also called CdiI immunity protein) of the CdiA effector protein from Escherichia coli A0 34/86, and similar proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via its C-terminal domain (CdiA-CT). The CdiI immunity proteins are intracellular proteins that inactivate the toxin/effector protein to prevent auto-inhibition. They are specific for their cognate CdiA-CT and do not protect cells from the toxins of other CDI+ bacteria. Thus, CDI systems encode a complex network of toxin-immunity protein pairs that are deployed for intercellular competition. This E. coli CdiI binds its cognate toxin CdiA-CT domain with high affinity.


Pssm-ID: 412047  Cd Length: 124  Bit Score: 136.91  E-value: 2.05e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772674740  28 PLFSECVNALGKGVIIYSPEKSEERYCSFQKEVPFTFYGRIEWDKFDKYcVITYLEDVKSLIN--DDDLEIYWSTDNFPV 105
Cdd:cd20693     2 TLFEECIEALGEDFRILSDEESKEIYDKFENYFPFTSWGRIDWSKINKK-DIEIIDELLSLLNlkNEEVYIIWDDADIPV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1772674740 106 LKTKFENILSVYDDVVAVDSNTFLYIENKYVIEIYHDGEMRIG 148
Cdd:cd20693    81 IKTNLKLILENIDDVTAVSFDTWIFNPENYVIEFYHEGEITVG 123
 
Name Accession Description Interval E-value
CdiI_EcoliA0-like cd20693
inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of ...
 28-148 2.05e-42

inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of Escherichia coli A0 34/86, and similar proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the inhibitor (CdiI, also called CdiI immunity protein) of the CdiA effector protein from Escherichia coli A0 34/86, and similar proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via its C-terminal domain (CdiA-CT). The CdiI immunity proteins are intracellular proteins that inactivate the toxin/effector protein to prevent auto-inhibition. They are specific for their cognate CdiA-CT and do not protect cells from the toxins of other CDI+ bacteria. Thus, CDI systems encode a complex network of toxin-immunity protein pairs that are deployed for intercellular competition. This E. coli CdiI binds its cognate toxin CdiA-CT domain with high affinity.


Pssm-ID: 412047  Cd Length: 124  Bit Score: 136.91  E-value: 2.05e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772674740  28 PLFSECVNALGKGVIIYSPEKSEERYCSFQKEVPFTFYGRIEWDKFDKYcVITYLEDVKSLIN--DDDLEIYWSTDNFPV 105
Cdd:cd20693     2 TLFEECIEALGEDFRILSDEESKEIYDKFENYFPFTSWGRIDWSKINKK-DIEIIDELLSLLNlkNEEVYIIWDDADIPV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1772674740 106 LKTKFENILSVYDDVVAVDSNTFLYIENKYVIEIYHDGEMRIG 148
Cdd:cd20693    81 IKTNLKLILENIDDVTAVSFDTWIFNPENYVIEFYHEGEITVG 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH