|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-540 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 666.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 1 MDSQRNILLIALALVSFLLFQQWQAAKNPAPQVIEQAQTSTTAPAPSFAdefdpapeqhraaaqtvtvttdvltLSIDTV 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQAAAQAPAPQARITVETDVLR-------------------------LSIDTK 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 81 GGDIIHALLNQYADELNSSTPFTLLRNEPNHLFIAQSGLIGPQGIDLSSNH-RPVYHVDGDHFALADGEQELRIPMTYQA 159
Cdd:PRK01318 56 GGRIDDLLLKKYKETLDSSPPVVLLSPSTEHPYFAQSGLTGADGPDNVPNPdRTLYTADGDSLVLADGQNELPVTLTWTN 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 160 -NGIEYVKTFIVRRGDYAVDVTFDVINRSGNNATLGMYAHLRQtllDSGGSLAMPTYRGGAYSTEDTRYKKFSFKDMQDR 238
Cdd:PRK01318 136 gNGLTFTKTYTLDRGDYMFTVEYSVNNNSGAPVNLSPYGQLKR---TGSSNFASYTFHGGAIGTPDEKYEKYTYKDIDDN 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 239 NlslPLPNGQGWAAMIQHYFASAWIPRNEPGTNLYSRVIGNVGDIGVRMPNKTIADGDATQFTATLWVGPKLQNEMAAT- 317
Cdd:PRK01318 213 L---NISSKGGWVAILDKYFATALIPQNGQNNFYSKNLGNGLYQVGFKSPPVTVAPGQSASTTARLYAGPKEVKLLAKEi 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 318 APNLDLVVDYGWLWFIAKPLHTLLSFIQSFVGNWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDD 397
Cdd:PRK01318 290 APGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDD 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 398 RQRMSQEMMELYKKEKVNPLGGCLPILLQMPIFIALYWALMESVELRHSPFFGWIHDLSAQDPYYIL-----PLLMGASM 472
Cdd:PRK01318 370 PQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVLLVSIELRHAPFIGWIHDLSAPDPYFILhigllPILMGITM 449
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777026756 473 FLIQKMSPNTiTDPMQQKIMTFMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRSLEKRGLHSK 540
Cdd:PRK01318 450 FLQQKLNPTP-TDPMQAKIMKFMPLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEKKKLLAA 516
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-349 |
1.97e-119 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 356.26 E-value: 1.97e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 3 SQRNILLIALALVSFLLFQQWQ---AAKNPAPQVIEQAQTSTTAPAPSFADefDPAPEQHRAAAQTVTVTTDVLTL---- 75
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQsdpGPPPPKPPAAAQEASAASATAAATSA--AAPAAADAPSAAAAADAAAATAKritv 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 76 -------SIDTVGGDIIHALLNQYADELNS-STPFTLLRNEPNHLFIAQSGLIGPQGIDLSS-NHRPVYHVDGDHFALAD 146
Cdd:TIGR03593 79 etdvlraSISTKGGDIDSLELKKYKETLDKdSPPVLLLSDGAERLYVAQSGLIGANGADLALpGHRTVWQAEGGEYTLTP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 147 GEqeLRIPMTYQA-NGIEYVKTFIVRRGDYAVDVTFDVINRSGNNATLGMYAHLRQTLLDS--GGSLAMPTYRGGAYSTE 223
Cdd:TIGR03593 159 GQ--LPVTLTWDNsNGVTVTKTYTFDRDSYLIDVEYKVTNNGDAPVSLSLYGQLKRDLSPTekSTYFLHETFTGAAYYTD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 224 DTRYKKFSFKDMQDRNLSLPLPNGQGWAAMIQHYFASAWIPRN----EPGTNLYSRVIGNVGDIGVRMPNKTIADGDATQ 299
Cdd:TIGR03593 237 GEKYQKVSFKDIEKKKLNVETKGGAGWVGMLQHYFASAWIPPAgsdgTTAFYYGRKLGNNVYIAGFVSPVVTVAPGQSAT 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1777026756 300 FTATLWVGPKLQNEMAATAPNLDLVVDYGWLWFIAKPLHTLLSFIQSFVG 349
Cdd:TIGR03593 317 IKSRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLVG 366
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
325-536 |
1.98e-115 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 340.17 E-value: 1.98e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 325 VDYGWLWFIAKPLHTLLSFIQSFVGNWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQE 404
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 405 MMELYKKEKVNPLGGCLPILLQMPIFIALYWALMESVELRHSPFFgWIHDLSAQDPYYI-LPLLMGASMFLIQKMSPNTI 483
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPFL-GIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1777026756 484 TDPMQQKIMTFMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRSLEKRG 536
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKKK 212
|
|
| 60KD_IMP |
pfam02096 |
60Kd inner membrane protein; |
351-530 |
6.24e-96 |
|
60Kd inner membrane protein;
Pssm-ID: 460443 [Multi-domain] Cd Length: 187 Bit Score: 289.37 E-value: 6.24e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 351 WGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPILLQMPIF 430
Cdd:pfam02096 1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 431 IALYWALMESVELRHSPFFGWIHDLSAQDP-----YYILPLLMGASMFLIQKMSPNTITDPMQQKIMT--FMPVMFTFFF 503
Cdd:pfam02096 81 IALYRVLRNSIELRHAPFFLWIADLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDQPPQMKMMMlyFMPLMFLFFF 160
|
170 180
....*....|....*....|....*..
gi 1777026756 504 LFFPSGLVLYWLVSNIVTLIQQTLIYR 530
Cdd:pfam02096 161 LNFPAGLVLYWVVSNLLSIGQQLIINR 187
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
352-530 |
9.06e-94 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 283.50 E-value: 9.06e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 352 GVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPILLQMPIFI 431
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 432 ALYWALMESVELRHSPFFGWIHDLSAQDPYYILPLLMGASMFLIQKMSP--NTITDPMQQKIMTFMPVMFTFFFLFFPSG 509
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPtpTDDQAPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 1777026756 510 LVLYWLVSNIVTLIQQTLIYR 530
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-540 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 666.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 1 MDSQRNILLIALALVSFLLFQQWQAAKNPAPQVIEQAQTSTTAPAPSFAdefdpapeqhraaaqtvtvttdvltLSIDTV 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQAAAQAPAPQARITVETDVLR-------------------------LSIDTK 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 81 GGDIIHALLNQYADELNSSTPFTLLRNEPNHLFIAQSGLIGPQGIDLSSNH-RPVYHVDGDHFALADGEQELRIPMTYQA 159
Cdd:PRK01318 56 GGRIDDLLLKKYKETLDSSPPVVLLSPSTEHPYFAQSGLTGADGPDNVPNPdRTLYTADGDSLVLADGQNELPVTLTWTN 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 160 -NGIEYVKTFIVRRGDYAVDVTFDVINRSGNNATLGMYAHLRQtllDSGGSLAMPTYRGGAYSTEDTRYKKFSFKDMQDR 238
Cdd:PRK01318 136 gNGLTFTKTYTLDRGDYMFTVEYSVNNNSGAPVNLSPYGQLKR---TGSSNFASYTFHGGAIGTPDEKYEKYTYKDIDDN 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 239 NlslPLPNGQGWAAMIQHYFASAWIPRNEPGTNLYSRVIGNVGDIGVRMPNKTIADGDATQFTATLWVGPKLQNEMAAT- 317
Cdd:PRK01318 213 L---NISSKGGWVAILDKYFATALIPQNGQNNFYSKNLGNGLYQVGFKSPPVTVAPGQSASTTARLYAGPKEVKLLAKEi 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 318 APNLDLVVDYGWLWFIAKPLHTLLSFIQSFVGNWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDD 397
Cdd:PRK01318 290 APGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDD 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 398 RQRMSQEMMELYKKEKVNPLGGCLPILLQMPIFIALYWALMESVELRHSPFFGWIHDLSAQDPYYIL-----PLLMGASM 472
Cdd:PRK01318 370 PQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVLLVSIELRHAPFIGWIHDLSAPDPYFILhigllPILMGITM 449
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777026756 473 FLIQKMSPNTiTDPMQQKIMTFMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRSLEKRGLHSK 540
Cdd:PRK01318 450 FLQQKLNPTP-TDPMQAKIMKFMPLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEKKKLLAA 516
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-349 |
1.97e-119 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 356.26 E-value: 1.97e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 3 SQRNILLIALALVSFLLFQQWQ---AAKNPAPQVIEQAQTSTTAPAPSFADefDPAPEQHRAAAQTVTVTTDVLTL---- 75
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQsdpGPPPPKPPAAAQEASAASATAAATSA--AAPAAADAPSAAAAADAAAATAKritv 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 76 -------SIDTVGGDIIHALLNQYADELNS-STPFTLLRNEPNHLFIAQSGLIGPQGIDLSS-NHRPVYHVDGDHFALAD 146
Cdd:TIGR03593 79 etdvlraSISTKGGDIDSLELKKYKETLDKdSPPVLLLSDGAERLYVAQSGLIGANGADLALpGHRTVWQAEGGEYTLTP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 147 GEqeLRIPMTYQA-NGIEYVKTFIVRRGDYAVDVTFDVINRSGNNATLGMYAHLRQTLLDS--GGSLAMPTYRGGAYSTE 223
Cdd:TIGR03593 159 GQ--LPVTLTWDNsNGVTVTKTYTFDRDSYLIDVEYKVTNNGDAPVSLSLYGQLKRDLSPTekSTYFLHETFTGAAYYTD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 224 DTRYKKFSFKDMQDRNLSLPLPNGQGWAAMIQHYFASAWIPRN----EPGTNLYSRVIGNVGDIGVRMPNKTIADGDATQ 299
Cdd:TIGR03593 237 GEKYQKVSFKDIEKKKLNVETKGGAGWVGMLQHYFASAWIPPAgsdgTTAFYYGRKLGNNVYIAGFVSPVVTVAPGQSAT 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1777026756 300 FTATLWVGPKLQNEMAATAPNLDLVVDYGWLWFIAKPLHTLLSFIQSFVG 349
Cdd:TIGR03593 317 IKSRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLVG 366
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
325-536 |
1.98e-115 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 340.17 E-value: 1.98e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 325 VDYGWLWFIAKPLHTLLSFIQSFVGNWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQE 404
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 405 MMELYKKEKVNPLGGCLPILLQMPIFIALYWALMESVELRHSPFFgWIHDLSAQDPYYI-LPLLMGASMFLIQKMSPNTI 483
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPFL-GIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1777026756 484 TDPMQQKIMTFMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRSLEKRG 536
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKKK 212
|
|
| yidC_oxa1_cterm |
TIGR03592 |
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ... |
350-528 |
9.19e-98 |
|
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274665 [Multi-domain] Cd Length: 179 Bit Score: 293.62 E-value: 9.19e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 350 NWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPILLQMPI 429
Cdd:TIGR03592 1 NWGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 430 FIALYWALMESVELRHSPFFgWIHDLSAQDPYYILPLLMGASMFLIQKMSPNTITDPMQQKIMT-FMPVMFTFFFLFFPS 508
Cdd:TIGR03592 81 FIALYQVLLRSIELRHAPFL-WIIDLSSPDPYYILPILMGVTMFLQQKLSPKGPPDPAQQKMMMyFMPLMFLFFFLSFPA 159
|
170 180
....*....|....*....|
gi 1777026756 509 GLVLYWLVSNIVTLIQQTLI 528
Cdd:TIGR03592 160 GLVLYWVVSNLFTIIQQLII 179
|
|
| 60KD_IMP |
pfam02096 |
60Kd inner membrane protein; |
351-530 |
6.24e-96 |
|
60Kd inner membrane protein;
Pssm-ID: 460443 [Multi-domain] Cd Length: 187 Bit Score: 289.37 E-value: 6.24e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 351 WGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPILLQMPIF 430
Cdd:pfam02096 1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 431 IALYWALMESVELRHSPFFGWIHDLSAQDP-----YYILPLLMGASMFLIQKMSPNTITDPMQQKIMT--FMPVMFTFFF 503
Cdd:pfam02096 81 IALYRVLRNSIELRHAPFFLWIADLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDQPPQMKMMMlyFMPLMFLFFF 160
|
170 180
....*....|....*....|....*..
gi 1777026756 504 LFFPSGLVLYWLVSNIVTLIQQTLIYR 530
Cdd:pfam02096 161 LNFPAGLVLYWVVSNLLSIGQQLIINR 187
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
352-530 |
9.06e-94 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 283.50 E-value: 9.06e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 352 GVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPILLQMPIFI 431
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 432 ALYWALMESVELRHSPFFGWIHDLSAQDPYYILPLLMGASMFLIQKMSP--NTITDPMQQKIMTFMPVMFTFFFLFFPSG 509
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPtpTDDQAPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 1777026756 510 LVLYWLVSNIVTLIQQTLIYR 530
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| YidC_periplas |
pfam14849 |
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein ... |
76-327 |
6.55e-90 |
|
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins.
Pssm-ID: 464346 Cd Length: 266 Bit Score: 276.85 E-value: 6.55e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 76 SIDTVGGDIIHALLNQYADELNS-STPFTLLRNEPNHLFIAQSGLIGPQGIDLSsNHRPVYHVDGDHFALADGEQELRIP 154
Cdd:pfam14849 11 SISLKGGRIDDLELKKYRETLDDdSPPVVLLSPSGGRTYVAQSGLIGAGGPDLP-PHDTVFTAEGGSYTLADGTDELPVT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 155 MTYQA-NGIEYVKTFIVRRGDYAVDVTFDVINRSGNNATLGMYAHLRQTLLDSGGSLAMPTYRGGAYSTEDTRYKKFSFK 233
Cdd:pfam14849 90 LTWDNgNGVTFTKTYTFDRGSYLIDVTYEVENTSGAPVTLQPYGQLVRDPGEPEGSSFYITYTGAAGSTDEGKYQKVSFD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 234 DMQD-RNLSLPLPNGQGWAAMIQHYFASAWIPRNEPGTN-LYSRVI-GNVGDIGVRMPNKTIADGDATQFTATLWVGPKL 310
Cdd:pfam14849 170 DIEKgGKLKVDTTTGGGWVAMTQHYFLSAWIPDQDGTTNeFYTRFLgGNLYQAGYISPAVTVAPGASATVTARLFAGPKE 249
|
250
....*....|....*..
gi 1777026756 311 QNEMAATAPNLDLVVDY 327
Cdd:pfam14849 250 QKVLEAIAPGLDLAVDY 266
|
|
| 5TM_YidC_Oxa1_Alb3 |
cd19751 |
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ... |
352-530 |
4.75e-72 |
|
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410992 [Multi-domain] Cd Length: 189 Bit Score: 227.82 E-value: 4.75e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 352 GVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDD------RQRMSQEMMELYKKEKVNPLGGCLPILL 425
Cdd:cd19751 1 GLSIIIVTILIRLALLPLTLKQQKSMRKMQVIRPEMEAIREKYKEKaskdkvQQEMQKEMLGLYKKHGVNPMAGCLPLFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 426 QMPIFIALYWALMESVELRHSPFFgWIHDLSAQDPYYILPLLMGASMFLIQKMSPNTIT-----DPMQQKIMTFMPVMFT 500
Cdd:cd19751 81 QLPIFMAFYFAIMRTEEIRYHTFL-WFFDLGQPDYLYILPFVAGITTYFQFKMTMSHQQqmqmmQMQMKVMLYVMPVMII 159
|
170 180 190
....*....|....*....|....*....|
gi 1777026756 501 FFFLFFPSGLVLYWLVSNIVTLIQQTLIYR 530
Cdd:cd19751 160 IAGLSFPSALSLYWIISNLFMIIQTYFIVR 189
|
|
| EcYidC-like_peri |
cd19961 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
76-327 |
2.28e-61 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Escherichia coli and similar domains; This subfamily is composed of Escherichia coli YidC and similar proteins. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contain a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich.
Pssm-ID: 411000 Cd Length: 255 Bit Score: 202.54 E-value: 2.28e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 76 SIDTVGGDIIHALLNQYADELNSSTPFTLLrnEPNHLFIAQSGLIGPQGIDlSSNHRPVYHVDGDHFALADgeqELRIPM 155
Cdd:cd19961 13 SISTKGGRIKSVELKKYKETLPDSKPVELL--SPDGPYVAQLGLIGADGPL-IPTADLLFTADSGSYEGGD---SLTVTL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 156 TYQ-ANGIEYVKTFIVRRGDYAVDVTFDVINRSGNNATLGMYAHLRQTLLDSGGSLAMPTYRGGAYSTEDtRYKKFSFKD 234
Cdd:cd19961 87 TWTnGDGLTIEKTYTFDPDSYLIDVEVRVENNSSAPLSLSLYLQLQRKGGEPEGSGSTITYEGPAGTEDG-KLEKLSFKD 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 235 MQDRNLSlplPNGQGWAAMIQHYFASAWIPRNEPGTNLYSRVIGNVGDIGVRMPNKTIADGDATQFTATLWVGPKLQNEM 314
Cdd:cd19961 166 LEEEKLS---SGKVGWVAFKQKYFLSALIPDQGFFYSAKLSGKDDGDGVKLLSAALTLPPGGSGTFSFRLYAGPKDYDIL 242
|
250
....*....|...
gi 1777026756 315 AATAPNLDLVVDY 327
Cdd:cd19961 243 KAYGPGLELAVDF 255
|
|
| PRK01315 |
PRK01315 |
putative inner membrane protein translocase component YidC; Provisional |
331-530 |
2.79e-45 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234941 Cd Length: 329 Bit Score: 162.21 E-value: 2.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 331 WFIAKPL---HTLLSFIqsFVGN----WGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQ 403
Cdd:PRK01315 17 WVISGILvlfHTLLGFL--FGPDsgltWVLSIVGLVIVIRALLIPLFVKQIKSQRNMQEIQPKMKKIQEKYKGDRERMSQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 404 EMMELYKKEKVNPLGGCLPILLQMPIFIALYWALMESVE---------------LRHSPFFGW-IHD--LSAQDPYY--- 462
Cdd:PRK01315 95 EMMKLYKETGTNPLSSCLPLLLQMPIFFALYRVLDSAASrgdgigpinppllesFRHAHIFGApLAAtfLQALNAGNtav 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 463 -----ILPLLMGASMFLIQK------MSPNTITDPM--QQKIMTFM-PVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLI 528
Cdd:PRK01315 175 qvvaaVLIILMSASQFITQLqlmtknMPPEAKTGPMaqQQKMLLYLfPLMFLVSGIAFPVGVLFYWLTSNVWTMGQQFYV 254
|
..
gi 1777026756 529 YR 530
Cdd:PRK01315 255 IR 256
|
|
| PRK00145 |
PRK00145 |
putative inner membrane protein translocase component YidC; Provisional |
343-536 |
9.91e-45 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234665 [Multi-domain] Cd Length: 223 Bit Score: 157.21 E-value: 9.91e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 343 FIQSFVGN----WGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEMMELYKKEKVNPLG 418
Cdd:PRK00145 19 FVSSVISNpnfsYGIAIILVTLIIRLLILPLNIKQTKSSLRMNEIQPEIKKLQAKYKNDPQKLQQEMMKLYKEKGVNPLG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 419 GCLPILLQMPIFIALYWALMESVELRHSPFFgWIHDLSAQDPYYILPLLMGASMFLIQK-MSPNTITDPMQQKIMT-FMP 496
Cdd:PRK00145 99 GCLPLLIQWPILIALYYVFNNLTGINGVSFL-WIKDLAKPDITWILPILSGATTYLSGYlMTKADSSQAGQMKTMNiGMS 177
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1777026756 497 VMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRSLEKRG 536
Cdd:PRK00145 178 IFMGVMSWKFKSALVLYWVIGNLIQIIQTYFIKKLELKKK 217
|
|
| PRK01001 |
PRK01001 |
putative inner membrane protein translocase component YidC; Provisional |
321-540 |
1.60e-43 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234887 [Multi-domain] Cd Length: 795 Bit Score: 165.36 E-value: 1.60e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 321 LDLVVDYGWLWFIAKPLHTLLSFIQSF----VGNWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGD 396
Cdd:PRK01001 542 LDSITFRGFFSFITEPFAALLFIIMKFfkflTGSWGISIILLTVFLKLLLYPLNAWSIRSMRRMQKLSPYIQEIQQKYKK 621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 397 DRQRMSQEMMELYKKEKVNPLGGCLPILLQMPIFIALYWALMESVELRHSPFF-GWIHDLSAQD--------------PY 461
Cdd:PRK01001 622 EPKRAQMEIMALYKTNKVNPITGCLPLLIQLPFLIAMFDLLKSSFLLRGASFIpGWIDNLTAPDvlfswetpiwfignEF 701
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 462 YILPLLMGASMFLIQKMSPNTITDPM-----QQKIM-TFMPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRSLEKR 535
Cdd:PRK01001 702 HLLPILLGVVMFAQQKISSLKRKGPVtdqqrQQEAMgTMMALLFTFMFYNFPSGLNIYWLSSMLLGVIQQWVTNKILDSK 781
|
....*
gi 1777026756 536 GLHSK 540
Cdd:PRK01001 782 HLKNE 786
|
|
| PRK02944 |
PRK02944 |
YidC family membrane integrase SpoIIIJ; |
329-528 |
4.54e-42 |
|
YidC family membrane integrase SpoIIIJ;
Pssm-ID: 179508 Cd Length: 255 Bit Score: 151.46 E-value: 4.54e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 329 WLWFIAKPLHTLLSFI-QSFVGNWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDD----RQRMSQ 403
Cdd:PRK02944 36 WNEYFVYPLSQLITYFaNLFGSNYGLAIIVVTLLIRLLILPLMIKQTKSTKAMQALQPEMQKLKEKYSSKdqatQQKLQQ 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 404 EMMELYKKEKVNPLGGCLPILLQMPIFIALYWALMESVELRHSPFFgWIhDLSAQDPYYILPLLMGASMFLIQK-MSPNT 482
Cdd:PRK02944 116 EMMQLFQKNGVNPLAGCLPIFIQMPILIAFYHAIMRTSEISKHSFL-WF-DLGQADPYYILPIVAGITTFIQQKlMMAGT 193
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1777026756 483 ITDPMQQKIMTF-MPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLI 528
Cdd:PRK02944 194 AGQNPQMAMMLWlMPIMILIFAINFPAALSLYWVVGNIFMIAQTYLI 240
|
|
| 5TM_Oxa1-like |
cd20069 |
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ... |
351-531 |
3.96e-41 |
|
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410993 [Multi-domain] Cd Length: 201 Bit Score: 146.90 E-value: 3.96e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 351 WGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERI------GDD--RQRMSQEMMELYKKEKVNPLGGCLP 422
Cdd:cd20069 4 WWATIAATTVALRLLLLPLVIKSQRNAARMANLQPELQKLQEKLkearasGDQleAAEARKELKELMKKHNVNPLKSLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 423 ILLQMPIFIALYWALMESVELRHSPF----FGWIHDLSAQDPYYILPLLMGASMFLI-----QKMSPNTITDPMQQKIMT 493
Cdd:cd20069 84 PLVQAPVFISFFFALRKMANLPVPSFktggLLWFTDLTVPDPYYILPILTSLTFLATielgaETGTSGSPQSKTMKNVFR 163
|
170 180 190
....*....|....*....|....*....|....*...
gi 1777026756 494 FMPVMFTFFFLFFPSGLVLYWLVSNIVTLIqQTLIYRS 531
Cdd:cd20069 164 GLPVLMIPFTANFPSAVFLYWITSNLFSLA-QNLLLRI 200
|
|
| PRK01622 |
PRK01622 |
membrane protein insertase YidC; |
315-534 |
2.96e-40 |
|
membrane protein insertase YidC;
Pssm-ID: 179310 Cd Length: 256 Bit Score: 146.44 E-value: 2.96e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 315 AATAPNLDLVVDYGWLWFIAKPLHTLLSFIQSFV-GNWGVAIICLTFIVRGAMYPLTKAQYTSM----AKMRMLQPKLQA 389
Cdd:PRK01622 23 CSNAAPIDAHSDGFFDHYFVYPFSFLIQFVAHHIgGSYGIAIIIVTLIIRSLMIPLAVSQYKSQrgmqEKMAVMKPELDK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 390 MRERIG-----DDRQRMSQEMMELYKKEKVNPLG-GCLPILLQMPIFIALYWALMESVELRHSPFFgWIhDLSAQDpyYI 463
Cdd:PRK01622 103 IQAKLKvtkdlEKQKEYQKEMMELYKSGNINPLAmGCLPLLIQMPILSAFYYAIRRTEEIASHSFL-WF-NLGHAD--HI 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1777026756 464 LPLLMGASMFLIQKMSPNTITDPMQQ---KIMTFM-PVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLIYRSLEK 534
Cdd:PRK01622 179 LPIIAGLTYFIQMKVSQSNGTSPEQVqmlKIQGIMmPAMILFMSFAAPSALVLYWITGGLFLMGQTIVLRKVMER 253
|
|
| PRK03449 |
PRK03449 |
putative inner membrane protein translocase component YidC; Provisional |
329-534 |
1.10e-31 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 179580 Cd Length: 304 Bit Score: 124.02 E-value: 1.10e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 329 WLWfiakplHTLLSFI---QSFVGnWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEM 405
Cdd:PRK03449 14 WFW------HKLFSFVlgpDNGFA-WALSVMFLVFTLRALLYKPFVRQIRTTRKMQELQPQIKALQKKYGNDRQKMALEM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 406 MELYKKEKVNPLGGCLPILLQMPIFIALYWAL--------------MESVELRHSP--FFGwIHD-------------LS 456
Cdd:PRK03449 87 QKLQKEHGFNPILGCLPMLAQIPVFLGLFHVLrsfnrtgtgfgqlgMSVEENRNTPnyVFS-AEDvqsfldarlfgapLS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 457 A----QDPYY--------------ILPLLMGASMFL-------IQKMSPNTITDP---MQQKIMT-FMPVMFTFFFLFFP 507
Cdd:PRK03449 166 AyitmPRSGLdafvdftrtniilvGVPLMIIAGVAThfnsrasVARQSAEAAANPqtaMMNKLALwVFPLGVLVGGPFLP 245
|
250 260
....*....|....*....|....*..
gi 1777026756 508 SGLVLYWLVSNIVTLIQQTLIYRSLEK 534
Cdd:PRK03449 246 LAILLYWVSNNIWTFGQQHYVFGKIDK 272
|
|
| PRK02463 |
PRK02463 |
OxaA-like protein precursor; Provisional |
327-528 |
3.91e-27 |
|
OxaA-like protein precursor; Provisional
Pssm-ID: 235040 Cd Length: 307 Bit Score: 111.36 E-value: 3.91e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 327 YGWLW-FIAKPLHtllSFIQSFVGN----WGVAIICLTFIVRGAMYPLT-----KAQYTSmAKMRMLQPKLQAMRERIGD 396
Cdd:PRK02463 34 TGFIWnFLGAPMS---YFIDYFANNlglgFGLAIIIVTIIVRLIILPLGlyqswKATYQS-EKMAYLKPVFEPINERLKN 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 397 ---DRQRMS--QEMMELYKKEKVNPLG--GCLPILLQMPIFIALYWALMESVELRHSPFFGWihDLSAQDpyYILPLLMG 469
Cdd:PRK02463 110 attQEEKMAaqTELMAAQRENGISMLGgiGCLPLLIQMPFFSALYFAAQYTKGVSTSTFLGI--DLGSPS--LVLTAIIG 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1777026756 470 ASMFLIQKMSPNTITDPMQQKIMTF---MPVMFTFFFLFFPSGLVLYWLVSNIVTLIQQTLI 528
Cdd:PRK02463 186 VLYFFQSWLSMMGVPEEQREQMKAMmymMPIMMVVFSFSSPAGVGLYWLVGGFFSIIQQLIT 247
|
|
| PRK02654 |
PRK02654 |
putative inner membrane protein translocase component YidC; Provisional |
340-496 |
1.27e-26 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235058 Cd Length: 375 Bit Score: 111.23 E-value: 1.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 340 LLSFIQSFVGNWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQA----MRERIGDDRQRMSQEMMELYkKEKVN 415
Cdd:PRK02654 16 ILDFFYGIVPSYGLAIVALTLVIRFALYPLSAGSIRNMRRMKIAQPVMQKrqaeIQERYKNDPQKQQEEMGKLM-KEFGN 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 416 PLGGCLPILLQMPIFIALYwalmesVELRHSPFFGWIHDLSAQdpyyILPLLMGASmflIQ----KMSPNTI--TDPMQQ 489
Cdd:PRK02654 95 PLAGCLPLLVQMPILFALF------ATLRGSPFADVNYTVNLQ----VLPSEQIAA---VQpqpfKSKPQNIfiTDGVHF 161
|
....*..
gi 1777026756 490 KIMTFMP 496
Cdd:PRK02654 162 PVIASLP 168
|
|
| PRK00247 |
PRK00247 |
putative inner membrane protein translocase component YidC; Validated |
330-535 |
2.08e-16 |
|
putative inner membrane protein translocase component YidC; Validated
Pssm-ID: 178945 [Multi-domain] Cd Length: 429 Bit Score: 81.44 E-value: 2.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 330 LWFIAkpLHTLLSFIQSFVgnWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGD-----DRQRMSQE 404
Cdd:PRK00247 15 LWHLL--LHNVLGLDDSLA--WFASLFGLVITVRAIIAPFTWQQYKSGRTAAHIRPKRKALREEYKGktdeaSIRELQQK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 405 MMELYKKEKVNPLGGCLPILLQMPIFIALYWALM---ESVELRHSPFFGWIHDLSAQD--------------PYY----- 462
Cdd:PRK00247 91 QKDLNKEYGYNPLAGCVPALIQIPVFLGLYQVLLrmaRPEGGLENPVHQPIGFLTSEEvesflqgrvfnvplPAYvsmpa 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 463 ----------------ILPLLMGASMFLIQKMSPNTITDPMQ-----------QKIMTFMPVMFTFFFLFF------PSG 509
Cdd:PRK00247 171 eqlaylgttqatvlafVLPLFIAAAVFTAINMAMSTYRSFQTndhdsgfavgmLKFLIVMAILAPIFPLSLgltgpfPTA 250
|
250 260
....*....|....*....|....*.
gi 1777026756 510 LVLYWLVSNIVTLIQQTLIYRSLEKR 535
Cdd:PRK00247 251 IALYWVANNLWTLIQNIIMYLILERK 276
|
|
| PRK02201 |
PRK02201 |
putative inner membrane protein translocase component YidC; Provisional |
327-529 |
1.74e-15 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235012 Cd Length: 357 Bit Score: 78.13 E-value: 1.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 327 YGWL-WFIAK-PLHTLLSFIQSFVGNWGV--AIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKL---QAMRERIGDD-- 397
Cdd:PRK02201 105 YGLFvYPIAQiILSIMASQSLSELYGWSTilAIIVVVLIIRLISFLITFKSTFNQEKQEELQGKKakiDAKYKDYKKDkq 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 398 -RQRMSQEMMELYKKEKVNPLGGCLPILLQMPIFIALYWALMESVELRHSPFFG-------WIHDLSAQDPYYILPLLMG 469
Cdd:PRK02201 185 mKQRKQQEIQELYKKHNISPFSPFVQMFVTLPIFIAVYRVVQSLPSIKVTTWLGidlsatsWQEIFAGNWIYLPILIIVV 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 470 ASMFLIQKM--------SPNTITDPMQ----------QKIMT----FMPVMftffflfFPSGLVLYWLVSNIVTLIQQTL 527
Cdd:PRK02201 265 PVQALSQLLpqilnkkkNKERTLNVKEkealkkqnktQNIISivfiFFGVI-------FAAGVQIYWIIGGIWTILQTLG 337
|
..
gi 1777026756 528 IY 529
Cdd:PRK02201 338 IH 339
|
|
| YidC_peri |
cd19960 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
135-326 |
1.06e-08 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Gram-negative bacteria and similar domains; Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contains a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich. Other members of the YidC/Oxa1/Alb3 family include YidC1/YidC2 from gram-positive bacteria as well as eukaryotic members such as mitochondrial Oxa1/Oxa2 (or Cox18) and chloroplastic Alb3/Alb4; they are not part of this hierarchy as they do not possess the periplasmic domain.
Pssm-ID: 410999 Cd Length: 233 Bit Score: 55.72 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 135 YHVDGDHFALADGEQelRIPMTYQANGIEYVKTFIV-RRGDYAVDVTFdvinrSGNNA---TLGMyahlRQTLLDsggsl 210
Cdd:cd19960 67 YTASVSEIDLESGPQ--SVVLTQTLSGLTVTKTITFyPDGHYDVKVKL-----SKPVDyfiTPGQ----RPNAAV----- 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777026756 211 AMPTYRGGAYSTEDTRYKKFSFKDMQDRNLSlplpNGQGWAAMIQHYFASAWIPRNEPGTNLYSRviGNVGDigvrmPNK 290
Cdd:cd19960 131 DSYTVHGALVKTADGTITIIEDGDAEGTESF----SNVNIAASFDRYYATLFYNFDKGLNVVVTK--DASDN-----PLV 199
|
170 180 190
....*....|....*....|....*....|....*.
gi 1777026756 291 TIADGDatQFTATLWVGPKLQNEMAATAPNLDLVVD 326
Cdd:cd19960 200 FVKGNG--NFSLHGYIGPKEYKLLKSIDPELTDVIE 233
|
|
| |
