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Conserved domains on  [gi|1777563655|ref|WP_154256803|]
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MULTISPECIES: response regulator [Lactonifactor]

Protein Classification

response regulator( domain architecture ID 1000931)

two-component system response regulator contains a phosphoacceptor receiver (REC) domain and a helix-turn-helix (HTH) DNA-binding output domain; similar to YesN/AraC family transcriptional regulators

Gene Ontology:  GO:0000160|GO:0043565|GO:0003700
PubMed:  20226724

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
3-123 1.07e-49

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


:

Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 166.36  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd17536     1 VLIVDDEPLIREGLKKLIDWEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLK 123
Cdd:cd17536    81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKEELD 121
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
262-511 1.28e-24

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 102.94  E-value: 1.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 262 RLSGAFQTLQKYMDWALVLGSSVLIVYPKITQVQTQPLSYPVELEKEMRRELCAGRQKRIQQVGRAFREYFANGTVYAPR 341
Cdd:COG2207     6 LLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLAL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 342 EIKESYVRFLWSILNVGKEIDIEPLKAVGQQELLEDIMSAVTYDELEEILAGVTARIPVEGERDDNYLIQRTKSLIHEFY 421
Cdd:COG2207    86 LALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 422 RQGITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGE 501
Cdd:COG2207   166 LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGV 245
                         250
                  ....*....|
gi 1777563655 502 LPAEYRKRHQ 511
Cdd:COG2207   246 TPSEYRKRLR 255
 
Name Accession Description Interval E-value
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
3-123 1.07e-49

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 166.36  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd17536     1 VLIVDDEPLIREGLKKLIDWEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLK 123
Cdd:cd17536    81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKEELD 121
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
2-105 1.24e-41

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 144.15  E-value: 1.24e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIDPsYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:COG4753     1 KVLIVDDEPLIREGLKRILEWEAG-FEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIIL 79
                          90       100
                  ....*....|....*....|....
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:COG4753    80 SGYSDFEYAQEAIKLGADDYLLKP 103
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
3-116 3.47e-27

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 105.31  E-value: 3.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDPsyeIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGY---VVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILT 77
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLK 116
Cdd:pfam00072  78 AHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
262-511 1.28e-24

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 102.94  E-value: 1.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 262 RLSGAFQTLQKYMDWALVLGSSVLIVYPKITQVQTQPLSYPVELEKEMRRELCAGRQKRIQQVGRAFREYFANGTVYAPR 341
Cdd:COG2207     6 LLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLAL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 342 EIKESYVRFLWSILNVGKEIDIEPLKAVGQQELLEDIMSAVTYDELEEILAGVTARIPVEGERDDNYLIQRTKSLIHEFY 421
Cdd:COG2207    86 LALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 422 RQGITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGE 501
Cdd:COG2207   166 LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGV 245
                         250
                  ....*....|
gi 1777563655 502 LPAEYRKRHQ 511
Cdd:COG2207   246 TPSEYRKRLR 255
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
424-507 2.21e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 91.08  E-value: 2.21e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655  424 GITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGELP 503
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80

                   ....
gi 1777563655  504 AEYR 507
Cdd:smart00342  81 SEYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
430-509 2.62e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.95  E-value: 2.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 430 IAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLI-GSRMKLYEIASAVGYSDPKYFSRVFKEVTGELPAEYRK 508
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLeDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80

                  .
gi 1777563655 509 R 509
Cdd:pfam12833  81 R 81
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
1-118 1.87e-16

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 79.45  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEiriREGISKLLGKI--DPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLI-- 76
Cdd:TIGR02875   3 IRIVIADDN---KEFCNLLKEYLaaQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEIELSArp 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1777563655  77 KAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:TIGR02875  80 RVIMLSAFGQEKITQRAVALGADYYVLKPFDLEILAARIRQL 121
PRK15369 PRK15369
two component system response regulator;
2-141 1.88e-16

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 78.20  E-value: 1.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIdPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:PRK15369    5 KILLVDDHELIINGIKNMLAPY-PRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVL 83
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV------------EDQLKEARRNEGEHPEKLRSLEN 141
Cdd:PRK15369   84 TARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVavgkryidpalnREAILALLNADDTNPPLLTPRER 155
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
425-511 3.73e-16

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 78.86  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 425 ITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGELPA 504
Cdd:PRK10572  200 FDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPS 279

                  ....*..
gi 1777563655 505 EYRKRHQ 511
Cdd:PRK10572  280 EFRARCE 286
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
1-58 6.23e-13

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 63.36  E-value: 6.23e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1777563655    1 MRIVIVEDEIRIREGISKLLGKIDPSyeiVGEAENGWAGLELVKAARPDLVITDIKMP 58
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYE---VDEATDGEEALELLKEEKPDLILLDIMMP 55
 
Name Accession Description Interval E-value
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
3-123 1.07e-49

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 166.36  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd17536     1 VLIVDDEPLIREGLKKLIDWEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLK 123
Cdd:cd17536    81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKEELD 121
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
2-105 1.24e-41

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 144.15  E-value: 1.24e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIDPsYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:COG4753     1 KVLIVDDEPLIREGLKRILEWEAG-FEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIIL 79
                          90       100
                  ....*....|....*....|....
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:COG4753    80 SGYSDFEYAQEAIKLGADDYLLKP 103
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
1-135 6.75e-30

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 116.84  E-value: 6.75e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIdPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:COG3279     2 MKILIVDDEPLARERLERLLEKY-PDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1777563655  81 LSAYSEFAYaqQAIHLGVSEYILKPVAVGELAQSLKNVEDQLKEARRNEGEHPEK 135
Cdd:COG3279    81 TTAYDEYAL--EAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEK 133
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
1-129 4.12e-29

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 111.60  E-value: 4.12e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIdPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:COG4565     4 IRVLIVEDDPMVAELLRRYLERL-PGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIV 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLKEARRNE 129
Cdd:COG4565    83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQ 131
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
3-118 9.44e-29

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 109.91  E-value: 9.44e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKiDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd17535     1 VLIVDDHPLVREGLRRLLES-EPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLT 79
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd17535    80 AHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAV 115
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
1-118 1.54e-28

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 109.55  E-value: 1.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLL--IKA 78
Cdd:COG0784     6 KRILVVDDNPDNRELLRRLLERLG--YEVT-TAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPRLpdIPI 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1777563655  79 IVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:COG0784    83 IALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRL 122
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
1-133 2.63e-28

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 116.60  E-value: 2.63e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:COG2204     3 ARILVVDDDPDIRRLLKELLERAG--YEVE-TAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVIL 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLKEARRNEGEHP 133
Cdd:COG2204    80 LTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENAEDSG 132
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
3-116 3.47e-27

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 105.31  E-value: 3.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDPsyeIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGY---VVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILT 77
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLK 116
Cdd:pfam00072  78 AHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
1-137 9.59e-26

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 105.25  E-value: 9.59e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKD--GLLIKA 78
Cdd:COG3437     7 PTVLIVDDDPENLELLRQLLRTLG--YDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADpsTRDIPV 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1777563655  79 IVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVEdQLKEARRNEGEHPEKLR 137
Cdd:COG3437    84 IFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNAL-ELRRLQRELDDLVLYLK 141
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
5-105 1.15e-25

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 100.76  E-value: 1.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   5 IVEDEIRIREGISKLLGKIDpsyEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLSAY 84
Cdd:cd00156     2 IVDDDPAIRELLKSLLEREG---YEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAK 78
                          90       100
                  ....*....|....*....|.
gi 1777563655  85 SEFAYAQQAIHLGVSEYILKP 105
Cdd:cd00156    79 ADEEDAVRALELGADDYLVKP 99
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
262-511 1.28e-24

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 102.94  E-value: 1.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 262 RLSGAFQTLQKYMDWALVLGSSVLIVYPKITQVQTQPLSYPVELEKEMRRELCAGRQKRIQQVGRAFREYFANGTVYAPR 341
Cdd:COG2207     6 LLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLAL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 342 EIKESYVRFLWSILNVGKEIDIEPLKAVGQQELLEDIMSAVTYDELEEILAGVTARIPVEGERDDNYLIQRTKSLIHEFY 421
Cdd:COG2207    86 LALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 422 RQGITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGE 501
Cdd:COG2207   166 LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGV 245
                         250
                  ....*....|
gi 1777563655 502 LPAEYRKRHQ 511
Cdd:COG2207   246 TPSEYRKRLR 255
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
1-118 5.84e-24

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 99.26  E-value: 5.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:COG0745     2 PRILVVEDDPDIRELLADALEREG--YEVD-TAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIM 78
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:COG0745    79 LTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRAL 116
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
2-107 1.33e-23

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 95.73  E-value: 1.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGkiDPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:cd17555     2 TILVIDDDEVVRESIAAYLE--DSGFQVL-QAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVV 78
                          90       100
                  ....*....|....*....|....*.
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVA 107
Cdd:cd17555    79 SGAGVMSDAVEALRLGAWDYLTKPIE 104
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
3-123 2.05e-22

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 92.22  E-value: 2.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIdPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEH-PDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVT 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1777563655  83 AYSEfaYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLK 123
Cdd:cd17532    80 AYDE--YAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
424-507 2.21e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 91.08  E-value: 2.21e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655  424 GITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGELP 503
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80

                   ....
gi 1777563655  504 AEYR 507
Cdd:smart00342  81 SEYR 84
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
2-105 3.11e-22

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 91.78  E-value: 3.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIrireGISKLLGKI--DPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAI 79
Cdd:COG5803     4 KILIVDDQA----GIRMLLKEVlkKEGYEVF-QAANGKEALEKVKELKPDLVLLDMKMPGMDGIEILKEIKEIDPDIPVI 78
                          90       100
                  ....*....|....*....|....*.
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:COG5803    79 MMTAYGELDMVEEAKELGAKGYFTKP 104
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
1-115 5.63e-22

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 93.05  E-value: 5.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLL--IKA 78
Cdd:COG3706     2 ARILVVDDDPTNRKLLRRLLEAAG--YEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTadIPI 78
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1777563655  79 IVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSL 115
Cdd:COG3706    79 IFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
1-124 1.49e-21

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 90.14  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKiDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGlLIKAIV 80
Cdd:cd17541     1 IRVLIVDDSAVMRKLLSRILES-DPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAER-PTPVVM 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1777563655  81 LSAYSE--FAYAQQAIHLGVSEYILKPvaVGELAQSLKNVEDQLKE 124
Cdd:cd17541    79 VSSLTEegAEITLEALELGAVDFIAKP--SGGISLDLEEIAEELIE 122
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
1-148 1.69e-21

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 91.94  E-value: 1.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIdpSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDgLLIKAIV 80
Cdd:COG3707     4 LRVLVVDDEPLRRADLREGLREA--GYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEE-RPAPVIL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLKEARRNEGEHPEKLRSLE-----NICIGLLM 148
Cdd:COG3707    81 LTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEerkliERAKGILM 153
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
3-118 8.28e-21

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 87.71  E-value: 8.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLgKIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd19930     1 VLIAEDQEMVRGALAALL-ELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVT 79
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd19930    80 TFGRPGYFRRALAAGVDGYVLKDRPIEELADAIRTV 115
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
1-118 8.74e-21

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 87.72  E-value: 8.74e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKidPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:cd17542     1 KKVLIVDDAAFMRMMLKDILTK--AGYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIM 78
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd17542    79 CSAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKV 116
HTH_18 pfam12833
Helix-turn-helix domain;
430-509 2.62e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.95  E-value: 2.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 430 IAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLI-GSRMKLYEIASAVGYSDPKYFSRVFKEVTGELPAEYRK 508
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLeDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80

                  .
gi 1777563655 509 R 509
Cdd:pfam12833  81 R 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
409-511 1.77e-18

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 86.36  E-value: 1.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 409 LIQRTKSLIHEFYRQGITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDP 488
Cdd:COG4977   211 RLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSA 290
                          90       100
                  ....*....|....*....|...
gi 1777563655 489 KYFSRVFKEVTGELPAEYRKRHQ 511
Cdd:COG4977   291 SHFRRAFRRRFGVSPSAYRRRFR 313
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
2-115 2.23e-18

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 80.75  E-value: 2.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIdPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:cd19925     2 NVLIVEDDPMVAEIHRAYVEQV-PGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSL 115
Cdd:cd19925    81 TAANDVETVREALRLGVVDYLIKPFTFERLRQRL 114
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
3-118 3.54e-18

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 80.23  E-value: 3.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGkiDPSYEiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd17550     1 ILIVDDEEDIRESLSGILE--DEGYE-VDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMIS 77
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd17550    78 GHGTIETAVKATKLGAYDFIEKPLSLDRLLLTIERA 113
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
1-118 3.71e-18

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 80.46  E-value: 3.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpsYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:cd19923     1 MKVLVVDDFSTMRRIIKNLLKELG--FNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGALSHLPV 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1777563655  81 LSAYSEFAYAQ--QAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd19923    79 LMVTAEAKKENviAAAQAGVNNYIVKPFTAATLKEKLEKI 118
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
1-111 5.02e-18

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 79.77  E-value: 5.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKidPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGlLIKAIV 80
Cdd:cd19932     1 VRVLIAEDEALIRMDLREMLEE--AGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSEN-IAPIVL 77
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGEL 111
Cdd:cd19932    78 LTAYSQQDLVERAKEAGAMAYLVKPFSESDL 108
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
1-116 1.06e-17

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 78.80  E-value: 1.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGkiDPSYEIVGeAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:cd17554     1 KKILVVDDEENIRELYKEELE--DEGYEVVT-AGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVII 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1777563655  81 LSAYSEF-----AYAQQAihlgvseYILKPVAVGELAQSLK 116
Cdd:cd17554    78 CTAYSEYksdfsSWAADA-------YVVKSSDLTELKETIK 111
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
5-105 1.71e-17

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 77.83  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   5 IVEDEIRIREGISKLLGKIDpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLSAY 84
Cdd:cd17574     2 VVEDDEEIAELLSDYLEKEG--YEVD-TAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAK 78
                          90       100
                  ....*....|....*....|.
gi 1777563655  85 SEFAYAQQAIHLGVSEYILKP 105
Cdd:cd17574    79 DEEEDKVLGLELGADDYITKP 99
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
1-69 1.97e-17

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 78.40  E-value: 1.97e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKiDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEEL 69
Cdd:COG2197     2 IRVLIVDDHPLVREGLRALLEA-EPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL 69
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
1-117 2.49e-17

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 77.87  E-value: 2.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIdPSYEIVG-----EAengwagLELVKAARPDLVITDIKMPEMDGLQMLEELHKD--G 73
Cdd:cd17551     1 MRILIVDDNPTNLLLLEALLRSA-GYLEVVSftdprEA------LAWCRENPPDLILLDYMMPGMDGLEFIRRLRALpgL 73
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1777563655  74 LLIKAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKN 117
Cdd:cd17551    74 EDVPIVMITADTDREVRLRALEAGATDFLTKPFDPVELLARVRN 117
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
2-105 8.45e-17

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 76.11  E-value: 8.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKiDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLL--IKAI 79
Cdd:cd17561     3 KVLIADDNREFVQLLEEYLNS-QPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMRLEkrPKII 81
                          90       100
                  ....*....|....*....|....*.
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd17561    82 MLTAFGQEDITQRAVELGASYYILKP 107
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
2-117 1.16e-16

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 75.90  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIDpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:cd17569     2 TILLVDDEPNILKALKRLLRREG--YEVL-TATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRILL 78
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1777563655  82 SAYSEFAYAQQAIHLG-VSEYILKPVAVGELAQSLKN 117
Cdd:cd17569    79 TGYADLDAAIEAINEGeIYRFLTKPWDDEELKETIRQ 115
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
3-115 1.45e-16

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 75.58  E-value: 1.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKA---I 79
Cdd:cd17546     1 VLVVDDNPVNRKVLKKLLEKLG--YEVD-VAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEGGGRRtpiI 77
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSL 115
Cdd:cd17546    78 ALTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
1-118 1.87e-16

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 79.45  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEiriREGISKLLGKI--DPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLI-- 76
Cdd:TIGR02875   3 IRIVIADDN---KEFCNLLKEYLaaQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEIELSArp 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1777563655  77 KAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:TIGR02875  80 RVIMLSAFGQEKITQRAVALGADYYVLKPFDLEILAARIRQL 121
PRK15369 PRK15369
two component system response regulator;
2-141 1.88e-16

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 78.20  E-value: 1.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIdPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:PRK15369    5 KILLVDDHELIINGIKNMLAPY-PRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVL 83
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV------------EDQLKEARRNEGEHPEKLRSLEN 141
Cdd:PRK15369   84 TARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVavgkryidpalnREAILALLNADDTNPPLLTPRER 155
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
425-511 3.73e-16

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 78.86  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 425 ITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGELPA 504
Cdd:PRK10572  200 FDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPS 279

                  ....*..
gi 1777563655 505 EYRKRHQ 511
Cdd:PRK10572  280 EFRARCE 286
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
3-117 1.81e-15

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 72.38  E-value: 1.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLgKIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd19931     1 VLLIDDHPLLRKGIKQLI-ELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILT 79
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKN 117
Cdd:cd19931    80 VSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQ 114
PRK10693 PRK10693
two-component system response regulator RssB;
32-107 2.51e-15

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 76.57  E-value: 2.51e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1777563655  32 EAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLSAYSEFAYAQQAIHLGVSEYILKPVA 107
Cdd:PRK10693    2 LAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMADIAKALRLGVQDVLLKPVK 77
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
2-111 2.83e-15

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 77.97  E-value: 2.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKidPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:PRK11361    6 RILIVDDEDNVRRMLSTAFAL--QGFETH-CANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILM 82
                          90       100       110
                  ....*....|....*....|....*....|
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVAVGEL 111
Cdd:PRK11361   83 TAYAEVETAVEALRCGAFDYVIKPFDLDEL 112
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
3-117 3.05e-15

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 72.14  E-value: 3.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDpsYEIVGeAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd17549     1 VLLVDDDADVREALQQTLELAG--FRVRA-FADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILIT 77
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKN 117
Cdd:cd17549    78 GHGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVRR 112
PRK11697 PRK11697
two-component system response regulator BtsR;
1-145 3.87e-15

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 74.88  E-value: 3.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKiDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLliKAIV 80
Cdd:PRK11697    2 IKVLIVDDEPLAREELRELLQE-EGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLDPEHM--PYIV 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1777563655  81 -LSAYSEfaYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLKEARRNEGEHPEKLRSLEniCIG 145
Cdd:PRK11697   79 fVTAFDE--YAIKAFEEHAFDYLLKPIDPARLAKTLARLRQERSPQDVLLPEAQPPLKHIP--CTG 140
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
1-118 4.38e-15

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 71.41  E-value: 4.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDPSyEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:cd17593     1 MKVLICDDSSMARKQLARALPADWDV-EIT-FAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIV 78
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd17593    79 VSGDVQPEAKERVLELGALAFLKKPFDPEKLAQLLEEL 116
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
5-111 7.67e-15

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 70.71  E-value: 7.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   5 IVEDEIRIREGISKLLGKidPSYEiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLSAY 84
Cdd:cd17625     2 VVEDEKDLSEAITKHLKK--EGYT-VDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTAL 78
                          90       100
                  ....*....|....*....|....*..
gi 1777563655  85 SEFAYAQQAIHLGVSEYILKPVAVGEL 111
Cdd:cd17625    79 DAVEDRVKGLDLGADDYLPKPFSLAEL 105
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
3-115 8.57e-15

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 70.56  E-value: 8.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIdpSYEIVGeAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEEL--HKDGLLIKAIV 80
Cdd:cd17580     1 ILVVDDNEDAAEMLALLLELE--GAEVTT-AHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLreLPWLANTPAIA 77
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSL 115
Cdd:cd17580    78 LTGYGQPEDRERALEAGFDAHLVKPVDPDELIELI 112
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
2-118 9.30e-15

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 70.66  E-value: 9.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIdPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLL--IKAI 79
Cdd:cd17552     3 RILVIDDEEDIREVVQACLEKL-AGWEVL-TASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQANPETqsIPVI 80
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd17552    81 LLTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQIAKL 119
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
1-111 1.65e-14

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 69.74  E-value: 1.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpsYEIVGEAENGWAGLELVKAARPDLVITDIKMP-EMDGLQMLEELHKDgLLIKAI 79
Cdd:cd17534     1 KKILIVEDEAIIALDLKEILESLG--YEVVGIADSGEEAIELAEENKPDLILMDINLKgDMDGIEAAREIREK-FDIPVI 77
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKPVAVGEL 111
Cdd:cd17534    78 FLTAYSDEETLERAKETNPYGYLVKPFNEREL 109
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
2-118 2.66e-14

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 71.98  E-value: 2.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGkIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:PRK10651    8 TILLIDDHPMLRTGVKQLIS-MAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVF 86
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:PRK10651   87 SVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQA 123
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
2-105 3.14e-14

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 68.84  E-value: 3.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIDPSYEIVGEAENGWAGLElvkAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:cd19919     2 TVWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALA---SSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIM 78
                          90       100
                  ....*....|....*....|....
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd19919    79 TAHSDLDSAVSAYQGGAFEYLPKP 102
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
2-116 4.43e-14

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 68.73  E-value: 4.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKidPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:cd17553     2 KILIVDDQYGIRILLNEVFNK--EGYQTF-QAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIM 78
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLK 116
Cdd:cd17553    79 TAYGELDMIQESKELGALTHFAKPFDIDEIRDAVK 113
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
2-116 6.24e-14

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 67.95  E-value: 6.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLL---GkidpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLL--I 76
Cdd:cd17548     1 KILIVEDNPLNMKLARDLLesaG-----YEVL-EAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEDPATrdI 74
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1777563655  77 KAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLK 116
Cdd:cd17548    75 PVIALTAYAMKGDREKILEAGCDGYISKPIDTREFLETVA 114
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
2-118 9.61e-14

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 67.71  E-value: 9.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGkiDPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHK----DGLLIk 77
Cdd:cd17562     2 KILAVDDSASIRQMVSFTLR--GAGYEVV-EAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKlpayKFTPI- 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1777563655  78 aIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd17562    78 -LMLTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKV 117
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
2-120 1.37e-13

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 67.44  E-value: 1.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIDPSYEIVgEAENGWAGLELV-------KAARPDLVITDIKMPEMDGLQMLEELHKDGL 74
Cdd:cd17557     1 TILLVEDNPGDAELIQEAFKEAGVPNELH-VVRDGEEALDFLrgegeyaDAPRPDLILLDLNMPRMDGFEVLREIKADPD 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1777563655  75 L--IKAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVED 120
Cdd:cd17557    80 LrrIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSLGE 127
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
3-111 2.17e-13

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 66.64  E-value: 2.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLgkidpSYE--IVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:cd17627     1 ILVVDDDRAVRESLRRSL-----RFEgyEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILV 75
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGEL 111
Cdd:cd17627    76 LTARDSVSDRVAGLDAGADDYLVKPFALEEL 106
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
1-185 2.71e-13

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 69.18  E-value: 2.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKllGKIDPSYeIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK09836    1 MKLLIVEDEKKTGEYLTK--GLTEAGF-VVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVedqlkeARRNEGEHPEKLRSLENICIGLLMGTVAAdrelety 160
Cdd:PRK09836   78 LTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTL------LRRGAAVIIESQFQVADLMVDLVSRKVTR------- 144
                         170       180
                  ....*....|....*....|....*
gi 1777563655 161 lSGQYGIDPGGEFALLSFYLGKQYE 185
Cdd:PRK09836  145 -SGTRITLTSKEFTLLEFFLRHQGE 168
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
2-118 3.84e-13

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 66.12  E-value: 3.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKidPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLL--IKAI 79
Cdd:cd17618     2 TILIVEDEPAIREMIAFNLER--AGFDVV-EAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEMTrdIPII 78
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd17618    79 MLTARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAV 117
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
399-510 4.36e-13

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 70.47  E-value: 4.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 399 PVEGERDDnyLIQRTKSLIHEFYRQGITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLiGSRMKLYE 478
Cdd:COG2169    77 PGSPPRAD--LVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLL-QTGLSVTD 153
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1777563655 479 IASAVGYSDPKYFSRVFKEVTGELPAEYRKRH 510
Cdd:COG2169   154 AAYAAGFGSLSRFYEAFKKLLGMTPSAYRRGG 185
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
2-132 5.38e-13

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 67.25  E-value: 5.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIDpsYEiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:COG4567     6 SLLLVDDDEAFARVLARALERRG--FE-VTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVL 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLKEA-------RRNEGEH 132
Cdd:COG4567    83 TGYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAPAPpenpmslDRLEWEH 140
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
2-106 5.76e-13

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 64.83  E-value: 5.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIdpSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGL--LIKAI 79
Cdd:cd17538     1 KILVVDDEPANRELLEALLSAE--GYEVL-TADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPEtrHIPVI 77
                          90       100
                  ....*....|....*....|....*..
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKPV 106
Cdd:cd17538    78 MITALDDREDRIRGLEAGADDFLSKPI 104
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
1-58 6.23e-13

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 63.36  E-value: 6.23e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1777563655    1 MRIVIVEDEIRIREGISKLLGKIDPSyeiVGEAENGWAGLELVKAARPDLVITDIKMP 58
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYE---VDEATDGEEALELLKEEKPDLILLDIMMP 55
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
3-140 6.62e-13

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 67.43  E-value: 6.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDPSYEIVGEAEngwAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:COG4566     2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAE---AFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLT 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLKEARRNEGEHPEKLRSLE 140
Cdd:COG4566    79 GHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRAERARRAELRARLA 136
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
1-115 1.48e-12

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 64.00  E-value: 1.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:cd17563     1 KSLLLVDDDEVFAERLARALERRG--FEVE-TAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVV 77
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSL 115
Cdd:cd17563    78 LTGYASIATAVEAIKLGADDYLAKPADADEILAAL 112
PRK10610 PRK10610
chemotaxis protein CheY;
1-122 2.58e-12

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 63.84  E-value: 2.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIdpSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK10610    6 LKFLVVDDFSTMRRIVRNLLKEL--GFNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADGAMSALPV 83
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1777563655  81 LSAYSE-----FAYAQQAihlGVSEYILKPVAVGELAQSLKNVEDQL 122
Cdd:PRK10610   84 LMVTAEakkenIIAAAQA---GASGYVVKPFTAATLEEKLNKIFEKL 127
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
3-105 3.87e-12

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 62.40  E-value: 3.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLgkIDPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIK--AIV 80
Cdd:cd19927     1 ILLVDDDPGIRLAVKDYL--EDQGFTVI-AASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNADFDTipVIF 77
                          90       100
                  ....*....|....*....|....*
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd19927    78 LTAKGMTSDRIKGYNAGCDGYLSKP 102
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
3-106 5.40e-12

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 62.29  E-value: 5.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIRegisKLLGKI---DPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAI 79
Cdd:cd17565     1 FYIVDDDKNII----KILSDIiedDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFI 76
                          90       100
                  ....*....|....*....|....*..
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKPV 106
Cdd:cd17565    77 MISQVSDKEMIGKAYQAGIEFFINKPI 103
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
3-116 1.05e-11

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 61.84  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLgkidpsyEIVGEAENGWA-GLELVKAARPDL---VITDIKMPEMDGLQMLEELHKDGLLIKA 78
Cdd:cd17537     3 VYVVDDDEAVRDSLAFLL-------RSVGLAVKTFTsASAFLAAAPPDQpgcLVLDVRMPGMSGLELQDELLARGSNIPI 75
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1777563655  79 IVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLK 116
Cdd:cd17537    76 IFITGHGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIE 113
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
2-105 1.13e-11

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 61.36  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKidPSYeIVGEAENGWAGLELVKAARP-DLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:cd18160     1 TILLADDEPSVRKFIVTTLKK--AGY-AVTEAESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREARKIDPDVKILF 77
                          90       100
                  ....*....|....*....|....*
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd18160    78 ISGGAAAAPELLSDAVGDNATLKKP 102
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
33-117 1.39e-11

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 61.44  E-value: 1.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655  33 AENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELA 112
Cdd:cd17572    28 VETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHGSVDIAVEAMRLGAYDFLEKPFDADRLR 107

                  ....*
gi 1777563655 113 QSLKN 117
Cdd:cd17572   108 VTVRN 112
PRK10336 PRK10336
two-component system response regulator QseB;
1-227 1.78e-11

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 63.76  E-value: 1.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDPSYEIVGEaenGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK10336    1 MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQ---GRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVedqlkeARRNEGEHPEKLRslenicigllmgtvaadrelety 160
Cdd:PRK10336   78 LTARDALAERVEGLRLGADDYLCKPFALIEVAARLEAL------MRRTNGQASNELR----------------------- 128
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1777563655 161 lSGQYGIDPGGEFALLSfylGKQYERERKHTAIeIETMLKGMGGVphclfhLPEKSeILVLLYRWGD 227
Cdd:PRK10336  129 -HGNVMLDPGKRIATLA---GEPLTLKPKEFAL-LELLMRNAGRV------LPRKL-IEEKLYTWDE 183
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
2-104 2.01e-11

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 63.72  E-value: 2.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLgKIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:PRK10403    8 QVLIVDDHPLMRRGVRQLL-ELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIIL 86
                          90       100
                  ....*....|....*....|...
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILK 104
Cdd:PRK10403   87 TVSDASSDVFALIDAGADGYLLK 109
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-69 2.39e-11

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 65.17  E-value: 2.39e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKiDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEEL 69
Cdd:PRK00742    4 IRVLVVDDSAFMRRLISEILNS-DPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKI 71
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
5-118 2.89e-11

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 60.36  E-value: 2.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   5 IVEDEIRIREGISKLLGKidPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLL--IKAIVLS 82
Cdd:cd19937     2 VVDDEEDIVELLKYNLEK--EGYEVV-TAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTssIPIIMLT 78
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd19937    79 AKGEEFDKVLGLELGADDYITKPFSPRELLARVKAV 114
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
3-112 5.28e-11

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 59.81  E-value: 5.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKidpSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd17624     1 ILLVEDDALLGDGLKTGLRK---AGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILT 77
                          90       100       110
                  ....*....|....*....|....*....|
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELA 112
Cdd:cd17624    78 ARDGVDDRVAGLDAGADDYLVKPFALEELL 107
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
3-105 8.24e-11

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 58.93  E-value: 8.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIdpSYEIVgEAENGWAGLELVKAARP---------DLVITDIKMPEMDGLQMLEELHKDG 73
Cdd:cd19924     1 ILVVDDSPTARKQLRDLLKNL--GFEIA-EAVDGEEALNKLENLAKegndlskelDLIITDIEMPKMDGYELTFELRDDP 77
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1777563655  74 LL--IKAIVLSAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd19924    78 RLanIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
33-106 9.67e-11

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 58.68  E-value: 9.67e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1777563655  33 AENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLL--IKAIVLSAYSEFAYAQQAIHLGVSEYILKPV 106
Cdd:cd19920    28 ATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKADPATrhIPVIFLTALTDTEDKVKGFELGAVDYITKPF 103
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
3-105 1.11e-10

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 58.33  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGkiDPSYEiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELhKDGLLIKAIVLS 82
Cdd:cd17620     1 ILVIEDEPQIRRFLRTALE--AHGYR-VFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRL-REWSAVPVIVLS 76
                          90       100
                  ....*....|....*....|...
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd17620    77 ARDEESDKIAALDAGADDYLTKP 99
orf27 CHL00148
Ycf27; Reviewed
1-118 1.84e-10

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 61.27  E-value: 1.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIdpSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGlLIKAIV 80
Cdd:CHL00148    7 EKILVVDDEAYIRKILETRLSII--GYEVI-TASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKES-DVPIIM 82
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:CHL00148   83 LTALGDVSDRITGLELGADDYVVKPFSPKELEARIRSV 120
PRK15115 PRK15115
response regulator GlrR; Provisional
2-140 2.01e-10

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 62.93  E-value: 2.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEirirEGISKLLG-KIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK15115    7 HLLLVDDD----PGLLKLLGmRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVII 82
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPV-------AVGE-LAQSLKNVEDQLKEARRNEGehPEKLRSLE 140
Cdd:PRK15115   83 LTAHGSIPDAVAATQQGVFSFLTKPVdrdalykAIDDaLEQSAPATDERWREAIVTRS--PLMLRLLE 148
fixJ PRK09390
response regulator FixJ; Provisional
5-125 2.55e-10

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 60.02  E-value: 2.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   5 IVEDEIRIREGISKLLGKIDpsYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLSAY 84
Cdd:PRK09390    8 VVDDDEAMRDSLAFLLDSAG--FEVR-LFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTGH 84
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1777563655  85 SEFAYAQQAIHLGVSEYILKP----VAVGELAQSLKNVEDQLKEA 125
Cdd:PRK09390   85 GDVPLAVEAMKLGAVDFIEKPfedeRLIGAIERALAQAPEAAKSE 129
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
30-133 3.15e-10

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 62.36  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655  30 VGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVG 109
Cdd:PRK10365   32 VALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYSSVETAVEALKTGALDYLIKPLDFD 111
                          90       100
                  ....*....|....*....|....
gi 1777563655 110 ELAQSLknvEDQLKEARRNEGEHP 133
Cdd:PRK10365  112 NLQATL---EKALAHTHSIDAETP 132
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
3-105 4.03e-10

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 57.34  E-value: 4.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKidPSYEiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEEL--HKDGLLIKAIV 80
Cdd:cd17598     1 ILIVEDSPTQAEQLKHILEE--QGYK-VQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIksDPDLKDIPVIL 77
                          90       100
                  ....*....|....*....|....*...
gi 1777563655  81 LSAYSEfayAQQAIH---LGVSEYILKP 105
Cdd:cd17598    78 LTTLSD---PRDVIRgleCGADNFITKP 102
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-69 8.37e-10

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 60.28  E-value: 8.37e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKiDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEEL 69
Cdd:PRK12555    1 MRIGIVNDSPLAVEALRRALAR-DPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRI 68
PRK10360 PRK10360
transcriptional regulator UhpA;
1-118 1.43e-09

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 57.68  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGkIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDgllIKAIV 80
Cdd:PRK10360    2 ITVALIDDHLIVRSGFAQLLG-LEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKG---MATIM 77
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:PRK10360   78 LSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTV 115
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
1-104 1.85e-09

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 57.60  E-value: 1.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpsYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK09958    1 MNAIIIDDHPLAIAAIRNLLIKND--IEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIII 78
                          90       100
                  ....*....|....*....|....
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILK 104
Cdd:PRK09958   79 VSAKNDHFYGKHCADAGANGFVSK 102
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
2-116 2.16e-09

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 55.05  E-value: 2.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLgkidpSYE--IVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAI 79
Cdd:cd17615     1 RVLVVDDEPNITELLSMAL-----RYEgwDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVL 75
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLK 116
Cdd:cd17615    76 FLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVARLR 112
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
1-111 2.32e-09

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 55.22  E-value: 2.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKidpSYEIVGEAENGWAGLELVKAaRPD--LVITDIKMPEMDGLQMLEELH----KDGL 74
Cdd:cd17544     1 IKVLVVDDSATSRNHLRALLRR---HNFQVLEAANGQEALEVLEQ-HPDikLVITDYNMPEMDGFELVREIRkkysRDQL 76
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1777563655  75 LIkaIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGEL 111
Cdd:cd17544    77 AI--IGISASGDNALSARFIKAGANDFLTKPFLPEEF 111
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
3-116 5.63e-09

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 53.97  E-value: 5.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKidPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGlLIKAIVLS 82
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTK--EGYEVV-TAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTS-NVPIIMLT 76
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLK 116
Cdd:cd17614    77 AKDSEVDKVLGLELGADDYVTKPFSNRELLARVK 110
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
427-507 6.17e-09

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 57.42  E-value: 6.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 427 LDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGELPAEY 506
Cdd:PRK13500  225 LDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQW 304

                  .
gi 1777563655 507 R 507
Cdd:PRK13500  305 R 305
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
3-105 6.44e-09

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 53.21  E-value: 6.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGkiDPSYeIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd19935     1 ILVVEDEKKLAEYLKKGLT--EEGY-AVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLT 77
                          90       100
                  ....*....|....*....|...
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd19935    78 ARDSVEDRVKGLDLGADDYLVKP 100
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
3-105 7.10e-09

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 53.28  E-value: 7.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDPSYEIVGEAENGWaglELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd19928     1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLW---RWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMS 77
                          90       100
                  ....*....|....*....|...
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd19928    78 AQNTLMTAVKAAERGAFEYLPKP 100
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
427-507 7.22e-09

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 56.99  E-value: 7.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 427 LDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGELPAEY 506
Cdd:PRK13502  195 LDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQW 274

                  .
gi 1777563655 507 R 507
Cdd:PRK13502  275 R 275
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
445-509 1.04e-08

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 56.45  E-value: 1.04e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1777563655 445 FHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGELPAEYRKR 509
Cdd:PRK13501  213 FRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQR 277
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
1-84 1.20e-08

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 53.21  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDPSYeiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:cd17530     1 LRVLVLDDDPFQCMMAATILEDLGPGN--VDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVIL 78

                  ....
gi 1777563655  81 LSAY 84
Cdd:cd17530    79 MSGL 82
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
3-106 2.16e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 51.96  E-value: 2.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGkiDPSYeIVGEAENGWAGLELVKA-ARPDLVITDIKMP-EMDGLQMLEELHKDGLLIKAIV 80
Cdd:cd18161     1 VLVVEDDPDVRRLTAEVLE--DLGY-TVLEAASGDEALDLLESgPDIDLLVTDVIMPgGMNGSQLAEEARRRRPDLKVLL 77
                          90       100
                  ....*....|....*....|....*.
gi 1777563655  81 LSAYSEFAYAQQAIHLGVsEYILKPV 106
Cdd:cd18161    78 TSGYAENAIEGGDLAPGV-DVLSKPF 102
PRK15347 PRK15347
two component system sensor kinase;
1-115 2.45e-08

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 56.57  E-value: 2.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDPSYEIvgeAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKD--GL---- 74
Cdd:PRK15347  691 LQILLVDDVETNRDIIGMMLVELGQQVTT---AASGTEALELGRQHRFDLVLMDIRMPGLDGLETTQLWRDDpnNLdpdc 767
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1777563655  75 LIKAIVLSAYS-EFAYAQQAihlGVSEYILKPVAVGELAQSL 115
Cdd:PRK15347  768 MIVALTANAAPeEIHRCKKA---GMNHYLTKPVTLAQLARAL 806
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
3-105 2.46e-08

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 51.68  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREgiskllgkidpSYEIVGEAE--------NGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGL 74
Cdd:cd19936     1 IALVDDDRNILT-----------SVSMALEAEgfsvetytDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKST 69
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1777563655  75 LiKAIVLSAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd19936    70 L-PVIFLTSKDDEIDEVFGLRMGADDYITKP 99
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
340-511 3.03e-08

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 55.04  E-value: 3.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 340 PREIKESYVRFLwSILNVGKeidIEPLKAVGQ--QELLEDIM--SAVTYDELEEILAGVTARI-PVEGERDDN-----YL 409
Cdd:PRK09685  123 PRELVEQYFPGQ-KPACAGR---LSASLPMVQlsHRLLQQSMngPALSETESEALLEALIALLrPALHQRESVqprreRQ 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 410 IQRTKSLIHEFYRQ-GITLDEIAGQLKITPEYLGMQFHREtGSNFSSYMKKYRVKKAKELL--IGSRMKLYEIASAVGYS 486
Cdd:PRK09685  199 FQKVVALIDQSIQEeILRPEWIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCADDLrpAADDEKITSIAYKWGFS 277
                         170       180
                  ....*....|....*....|....*
gi 1777563655 487 DPKYFSRVFKEVTGELPAEYRKRHQ 511
Cdd:PRK09685  278 DSSHFSTAFKQRFGVSPGEYRRKFR 302
PRK10643 PRK10643
two-component system response regulator PmrA;
1-193 4.58e-08

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 53.89  E-value: 4.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDPSYEIVGEAENGWAGLElvkAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK10643    1 MKILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLE---SGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVedqlkeARRNEGeHPEKLRSLENICIGLLMGTVaadreletY 160
Cdd:PRK10643   78 LTARDTLEDRVAGLDVGADDYLVKPFALEELHARIRAL------IRRHQG-QGENELQVGNLTLNLGRQQV--------W 142
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1777563655 161 LSGQYGIDPGGEFALLSFYL---GKQYERERKHTAI 193
Cdd:PRK10643  143 LDGQELILTPKEFALLSRLMlkaGSPVHREILYQDI 178
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
49-112 5.39e-08

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 51.09  E-value: 5.39e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1777563655  49 DLVITDIKMPEMDGLQMLEELH--KDgllIKAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELA 112
Cdd:cd17584    46 DLVITDVHMPDMDGFEFLELIRleMD---LPVIMMSADGSTSTVMKGLAHGACDYLLKPVSIEDLK 108
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
3-116 5.71e-08

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 51.13  E-value: 5.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGkiDPSYEiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd19934     1 LLLVEDDALLAAQLKEQLS--DAGYV-VDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILT 77
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLK 116
Cdd:cd19934    78 ARDSWQDKVEGLDAGADDYLTKPFHIEELLARLR 111
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
3-116 6.20e-08

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 53.27  E-value: 6.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLgkiDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELhKDGLLIKAIVLS 82
Cdd:PRK10529    4 VLIVEDEQAIRRFLRTAL---EGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDL-RQWSAIPVIVLS 79
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLK 116
Cdd:PRK10529   80 ARSEESDKIAALDAGADDYLSKPFGIGELQARLR 113
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
3-105 9.06e-08

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 50.36  E-value: 9.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDpsYEIVGeAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDgLLIKAIVLS 82
Cdd:cd18159     1 ILIVEDDETIASLLKKHLEKWG--YEVVL-IEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQI-SNVPIIFIS 76
                          90       100
                  ....*....|....*....|...
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd18159    77 SRDDNMDQVMAINMGGDDYITKP 99
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
2-188 9.46e-08

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 52.80  E-value: 9.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKidPSYEIVgEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLL--IKAI 79
Cdd:PRK10161    4 RILVVEDEAPIREMVCFVLEQ--NGFQPV-EAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTrdIPVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVedqlkeARRNEGEHPEKLRSLENICIgllmgtvaaDRELET 159
Cdd:PRK10161   81 MLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAV------MRRISPMAVEEVIEMQGLSL---------DPTSHR 145
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1777563655 160 YLSGQYGIDPG-GEFALLSFYLG---KQYERER 188
Cdd:PRK10161  146 VMAGEEPLEMGpTEFKLLHFFMThpeRVYSREQ 178
PRK14084 PRK14084
DNA-binding response regulator;
1-122 1.02e-07

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 53.22  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK14084    1 MKALIVDDEPLARNELTYLLNEIG-GFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIF 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1777563655  81 LSAYSEFAYaqQAIHLGVSEYILKPVAVGELAQSLKNVEDQL 122
Cdd:PRK14084   80 ATAHDQFAV--KAFELNATDYILKPFEQKRIEQAVNKVRATK 119
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
2-130 2.11e-07

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 50.06  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLgkiDPSYEiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVL 81
Cdd:cd17596     2 TILVVDDEVRSLEALRRTL---EEDFD-VLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIII 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1777563655  82 SAYSEFAYAQQAIH-LGVSEYILKPVAVGELAQSLKNVEDQLKEARRNEG 130
Cdd:cd17596    78 SGYTDSEDIIAGINeAGIYQYLTKPWHPDQLLLTVRNAARLFELQRENER 127
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
34-110 3.26e-07

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 52.57  E-value: 3.26e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1777563655  34 ENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGE 110
Cdd:PRK10923   34 ENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDE 110
PRK10430 PRK10430
two-component system response regulator DcuR;
49-117 3.32e-07

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 51.26  E-value: 3.32e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1777563655  49 DLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKN 117
Cdd:PRK10430   51 DLILLDIYMQQENGLDLLPVLHEAGCKSDVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTG 119
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
409-509 4.41e-07

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 48.38  E-value: 4.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 409 LIQRTKSLIHEFYRQGITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDP 488
Cdd:PRK10219    6 IIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQ 85
                          90       100
                  ....*....|....*....|.
gi 1777563655 489 KYFSRVFKEVTGELPAEYRKR 509
Cdd:PRK10219   86 QTFSRVFRRQFDRTPSDYRHR 106
PRK09483 PRK09483
response regulator; Provisional
3-118 4.50e-07

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 50.87  E-value: 4.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDpSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:PRK09483    4 VLLVDDHELVRAGIRRILEDIK-GIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKIIMLT 82
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:PRK09483   83 VHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSV 118
PRK11517 PRK11517
DNA-binding response regulator HprR;
1-124 1.14e-06

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 49.51  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKllGKIDPSYeIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELhKDGLLIKAIV 80
Cdd:PRK11517    1 MKILLIEDNQRTQEWVTQ--GLSEAGY-VIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTL-RTAKQTPVIC 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELaqsLKNVEDQLKE 124
Cdd:PRK11517   77 LTARDSVDDRVRGLDSGANDYLVKPFSFSEL---LARVRAQLRQ 117
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
2-108 1.84e-06

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 49.25  E-value: 1.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIDpsYEIVGEAEnGWAGLELVKAARPDLVITDIKMPEMDGLQMLEEL--HKDGllikAI 79
Cdd:PRK10701    3 KIVFVEDDAEVGSLIAAYLAKHD--IDVTVEPR-GDRAEATILREQPDLVLLDIMLPGKDGMTICRDLrpKWQG----PI 75
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1777563655  80 VL--SAYSEFAYAqQAIHLGVSEYILK--PVAV 108
Cdd:PRK10701   76 VLltSLDSDMNHI-LALEMGACDYILKttPPAV 107
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
2-118 1.99e-06

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 46.60  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIDPSYEIVgeaENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELhKDGLLIKAIVL 81
Cdd:cd19938     1 RILIVEDEPKLAQLLIDYLRAAGYAPTLL---AHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREI-RRFSDVPIIMV 76
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd19938    77 TARVEEIDRLLGLELGADDYICKPYSPREVVARVKAI 113
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
2-117 2.70e-06

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 46.23  E-value: 2.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKidPSYEiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGlLIKAIVL 81
Cdd:cd17619     2 HILIVEDEPVTRATLKSYFEQ--EGYD-VSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQS-EVGIILV 77
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKN 117
Cdd:cd17619    78 TGRDDEVDRIVGLEIGADDYVTKPFNPRELLVRAKN 113
dpiA PRK10046
two-component response regulator DpiA; Provisional
1-115 2.95e-06

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 48.48  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIdPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK10046    5 LTLLIVEDETPLAEMHAEYIRHI-PGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGDVVF 83
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSL 115
Cdd:PRK10046   84 TTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTL 118
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
3-105 4.10e-06

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 45.22  E-value: 4.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDPSyeiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd19926     1 VLVVDDEPDIRELLEITLGRMGLD---VRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVIT 77
                          90       100
                  ....*....|....*....|...
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd19926    78 AYGSLDTAIEALKAGAFDFLTKP 100
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
2-106 4.65e-06

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 45.83  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIDPSYEIVgeaENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELhKDGLLIKAIVL 81
Cdd:cd17622     2 RILLVEDDPKLARLIADFLESHGFNVVVE---HRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDL-RPKYQGPILLL 77
                          90       100
                  ....*....|....*....|....*
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPV 106
Cdd:cd17622    78 TALDSDIDHILGLELGADDYVVKPV 102
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
2-111 7.08e-06

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 45.15  E-value: 7.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGK--IDPSYeivgeAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKD-GLLIka 78
Cdd:cd17626     2 RILVVDDDAALAEMIGIVLRGegFDPAF-----CGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAEsGVPI-- 74
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1777563655  79 IVLSAYSEFAYAQQAIHLGVSEYILKPVAVGEL 111
Cdd:cd17626    75 VMLTAKSDTVDVVLGLESGADDYVAKPFKPKEL 107
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
3-104 1.41e-05

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 46.02  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKiDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:PRK09935    6 VIIMDTHPIIRMSIEVLLQK-NSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLS 84
                          90       100
                  ....*....|....*....|..
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILK 104
Cdd:PRK09935   85 SKSECFYAGRAIQAGANGFVSK 106
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
470-508 1.45e-05

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 42.14  E-value: 1.45e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1777563655 470 IGSRMKLYEIASAVGYSdPKYFSRVFKEVTGELPAEYRK 508
Cdd:pfam00165   5 LSTNLTIADIADELGFS-RSYFSRLFKKYTGVTPSQYRH 42
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
3-118 1.64e-05

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 44.22  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDPSYEIVgeaENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLiKAIVLS 82
Cdd:cd17623     1 ILLIDDDRELTELLTEYLEMEGFNVRAA---HDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQV-PVLMLT 76
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNV 118
Cdd:cd17623    77 ARGDDIDRILGLELGADDYLPKPFNPRELVARIRAI 112
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
3-105 2.09e-05

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 43.54  E-value: 2.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIdpSYEIVgEAENGWAGLELVKAARP--DLVITDIKMPEMDGLQMLEEL--HKDGLLIKA 78
Cdd:cd17582     1 VLLVENDDSTRQIVTALLRKC--SYEVT-AASDGLQAWDVLEDEQNeiDLILTEVDLPVSSGFKLLSYImrHKICKNIPV 77
                          90       100
                  ....*....|....*....|....*..
gi 1777563655  79 IVLSAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd17582    78 IMMSSQDSVGVVFKCLSKGAADYLVKP 104
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
426-511 2.19e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 46.07  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 426 TLDEIAGQLKITPEYLGMQFhRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGELPAE 505
Cdd:PRK09978  160 TLARIASELLMSPSLLKKKL-REEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTE 238

                  ....*.
gi 1777563655 506 YRKRHQ 511
Cdd:PRK09978  239 YQERSA 244
PRK10371 PRK10371
transcriptional regulator MelR;
403-508 2.71e-05

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 45.97  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 403 ERDDNYlIQRTKSLIHEFYRQGITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASA 482
Cdd:PRK10371  187 RHAQFY-VSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALT 265
                          90       100
                  ....*....|....*....|....*.
gi 1777563655 483 VGYSDPKYFSRVFKEVTGELPAEYRK 508
Cdd:PRK10371  266 AGFRSSSRFYSTFGKYVGMSPQQYRK 291
pleD PRK09581
response regulator PleD; Reviewed
2-72 8.08e-05

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 44.89  E-value: 8.08e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1777563655   2 RIVIVED---EIRIREgiSKLLGKidpsYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKD 72
Cdd:PRK09581    4 RILVVDDipaNVKLLE--AKLLAE----YYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSD 71
ftrA PRK09393
transcriptional activator FtrA; Provisional
426-509 8.69e-05

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 44.57  E-value: 8.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 426 TLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGELPAE 505
Cdd:PRK09393  236 TVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRRAATSPAA 315

                  ....
gi 1777563655 506 YRKR 509
Cdd:PRK09393  316 YRKR 319
PRK10766 PRK10766
two-component system response regulator TorR;
2-117 8.77e-05

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 43.87  E-value: 8.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIRegiSKLLGKIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEEL--HKDgllIKAI 79
Cdd:PRK10766    4 HILVVEDEPVTR---ARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELrsRST---VGII 77
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1777563655  80 VLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKN 117
Cdd:PRK10766   78 LVTGRTDSIDRIVGLEMGADDYVTKPLELRELLVRVKN 115
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
2-111 1.40e-04

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 41.59  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLGKIDPSYEIVGeaeNGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELhKDGLLIKAIVL 81
Cdd:cd19939     1 RILIVEDELELARLTRDYLIKAGLEVSVFT---DGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREV-REHSHVPILML 76
                          90       100       110
                  ....*....|....*....|....*....|
gi 1777563655  82 SAYSEFAYAQQAIHLGVSEYILKPVAVGEL 111
Cdd:cd19939    77 TARTEEMDRVLGLEMGADDYLCKPFSPREL 106
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
3-111 2.61e-04

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 40.51  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGIsklLGKIDPSYEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd17594     2 VLVVDDDAAMRHLL---ILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISG 78
                          90       100
                  ....*....|....*....|....*....
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGEL 111
Cdd:cd17594    79 DRRDEIDRVVGLELGADDYLAKPFGLREL 107
REC_typeA_ARR cd17581
phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and ...
6-106 2.67e-04

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381119 [Multi-domain]  Cd Length: 122  Bit Score: 40.81  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   6 VEDEIRIREGISKLLGKidPSYEiVGEAENGWAGLEL-----------VKAARPDLVITDIKMPEMDGLQMLEELHKDGL 74
Cdd:cd17581     4 VDDSLVDRKVIERLLRI--SSCR-VTAVDSGKRALEFlgledeedssnFNEPKVNMIITDYCMPGMTGYDLLKKVKESSA 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1777563655  75 L--IKAIVLSAYSEFAYAQQAIHLGVSEYILKPV 106
Cdd:cd17581    81 LkeIPVVIMSSENIPTRISRCLEEGAEDFLLKPV 114
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
26-105 3.94e-04

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 40.40  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655  26 SYEIVgEAENGWAGLELVK--AARPD---LVITDIKMPEMDGLQMLE---ELHKDGlliKAIVLSAYSEFAYAQQAI-HL 96
Cdd:cd17595    27 DYRVL-RADSGAEALDALKelKLRGEavaLFLVDQRMPEMDGVEFLEkamELFPEA---KRVLLTAYADTDAAIRAInDV 102

                  ....*....
gi 1777563655  97 GVSEYILKP 105
Cdd:cd17595   103 QLDYYLLKP 111
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
2-86 4.69e-04

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 39.92  E-value: 4.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIR---EGISKLLGkidpsYEIVGEAENGWAGLELVKAARPDLVITDIKMPE-MDGLQMLEELHKDGlLIK 77
Cdd:cd17540     2 RVLIIEDEPLIAmdlEQIVEDLG-----HQVVGIARTRDEAVALARRERPDLILADIQLADgSSGIDAVNEILTTH-DVP 75

                  ....*....
gi 1777563655  78 AIVLSAYSE 86
Cdd:cd17540    76 VIFVTAYPE 84
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
3-105 5.12e-04

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 39.49  E-value: 5.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKidPSYEiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGlLIKAIVLS 82
Cdd:cd17621     1 VLVVEDEESFSDPLAYLLRK--EGFE-VTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARS-NVPVIMVT 76
                          90       100
                  ....*....|....*....|...
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd17621    77 AKDSEIDKVVGLELGADDYVTKP 99
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
50-122 5.54e-04

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 39.69  E-value: 5.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777563655  50 LVITDIKMPEMDGLQMLEELHK-----DGLLIkaIVLSAYSEFAYAQQAIHLGVSEYILKPVavgelaqSLKNVEDQL 122
Cdd:cd19933    49 LVLLDLCMPEMDGFEVALRIRKlfgrrERPLI--VALTANTDDSTREKCLSLGMNGVITKPV-------SLHALGDEL 117
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
421-510 8.12e-04

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 41.20  E-value: 8.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 421 YRQGITLDEIAGQLKITPEYLGMQFHRETGSNFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTG 500
Cdd:PRK13503  184 FAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFS 263
                          90
                  ....*....|
gi 1777563655 501 ELPAEYRKRH 510
Cdd:PRK13503  264 WSPRDIRQGR 273
PRK10816 PRK10816
two-component system response regulator PhoP;
1-130 9.22e-04

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 40.88  E-value: 9.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDpsyEIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK10816    1 MRVLVVEDNALLRHHLKVQLQDAG---HQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILV 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVedqlkeARRNEG 130
Cdd:PRK10816   78 LTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQAL------MRRNSG 121
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
1-126 1.17e-03

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 41.88  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIdpSYEiVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK10841  802 MMILVVDDHPINRRLLADQLGSL--GYQ-CKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGLTLPVIG 878
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVEDQLKEAR 126
Cdd:PRK10841  879 VTANALAEEKQRCLEAGMDSCLSKPVTLDVLKQTLTVYAERVRKSR 924
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
3-111 1.22e-03

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 38.54  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKidPSYeIVGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLS 82
Cdd:cd17616     1 VLLIEDDSATAQSIELMLKS--EGF-NVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILS 77
                          90       100
                  ....*....|....*....|....*....
gi 1777563655  83 AYSEFAYAQQAIHLGVSEYILKPVAVGEL 111
Cdd:cd17616    78 GLADIEDKVKGLGFGADDYMTKPFHKDEL 106
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
30-118 1.52e-03

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 41.26  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   30 VGEAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIVLSAYSEFAYAQQAIHLGVSEYILKPVAVG 109
Cdd:PRK09959   985 VDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGLTANAQANEREKGLSCGMNLCLFKPLTLD 1064

                   ....*....
gi 1777563655  110 ELAQSLKNV 118
Cdd:PRK09959  1065 VLKTHLSQL 1073
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
3-115 1.65e-03

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 38.40  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGKIDPSYeiVGEAENGWAGLELVKAARPDLVITDIKMPE-MDGLQMLEEL-HKDglLIKA-- 78
Cdd:cd17589     1 FLIVDDQPTFRSMLKSMLRSLGVTR--IDTASSGEEALRMCENKTYDIVLCDYNLGKgKNGQQLLEELrHKK--LISPst 76
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1777563655  79 --IVLSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSL 115
Cdd:cd17589    77 vfIMVTGESSRAMVLSALELEPDDYLLKPFTVSELRERL 115
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
1-133 3.42e-03

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 39.17  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVEDEIRIREGISKLLGKIDPSYEIVgeaENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIKAIV 80
Cdd:PRK11083    4 PTILLVEDEQAIADTLVYALQSEGFTVEWF---ERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIF 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKPVAVGELAQSLKNVedqLKEARRNEGEHP 133
Cdd:PRK11083   81 LTARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTI---LRRVKKFAAPSP 130
HTH_18 pfam12833
Helix-turn-helix domain;
479-510 5.18e-03

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 36.03  E-value: 5.18e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1777563655 479 IASAVGYSdPKYFSRVFKEVTGELPAEYRKRH 510
Cdd:pfam12833   1 LAAALGMS-PRTLSRLFKRELGLSPKEYLRRL 31
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
2-104 5.27e-03

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 37.00  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   2 RIVIVEDEIRIREGISKLLG---KIDPSYeivgeAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLL--I 76
Cdd:cd17575     2 MVLLVDDQAIIGEAVRRALAdeeDIDFHY-----CSDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANPATrdI 76
                          90       100
                  ....*....|....*....|....*...
gi 1777563655  77 KAIVLSAYSEFAYAQQAIHLGVSEYILK 104
Cdd:cd17575    77 PIIVLSTKEEPEVKSEAFALGANDYLVK 104
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
3-105 7.20e-03

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 36.19  E-value: 7.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   3 IVIVEDEIRIREGISKLLGkiDPSYEIVGEAENGWAGLELVkAARPDLVITDIKMPEMDGLQMLEELHKDGLL--IKAIV 80
Cdd:cd17602     1 VACVDDRPSIQKMIEYFLE--KQGFRVVVIDDPLRALTTLL-NSKPDLILIDIDMPDLDGYELCSLLRKSSALkdTPIIM 77
                          90       100
                  ....*....|....*....|....*
gi 1777563655  81 LSAYSEFAYAQQAIHLGVSEYILKP 105
Cdd:cd17602    78 LTGKDGLVDRIRAKMAGASGYLTKP 102
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
426-506 9.41e-03

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 38.12  E-value: 9.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655 426 TLDEIAGQLKITPEYLGMQFHRETGSnFSSYMKKYRVKKAKELLIGSRMKLYEIASAVGYSDPKYFSRVFKEVTGELPAE 505
Cdd:PRK15186  199 ALKDISDSLYMSCSTLKRKLKQENTS-FSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSE 277

                  .
gi 1777563655 506 Y 506
Cdd:PRK15186  278 F 278
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
1-116 9.76e-03

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 38.77  E-value: 9.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777563655   1 MRIVIVED-EIRIREGISkLLGKIDPSYEIvgeAENGWAGLELVKAARPDLVITDIKMPEMDGLQMLEELHKDGLLIK-- 77
Cdd:PRK11091  526 LNILLVEDiELNVIVARS-VLEKLGNSVDV---AMTGKEALEMFDPDEYDLVLLDIQLPDMTGLDIARELRERYPREDlp 601
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1777563655  78 ------AIVLSAYSEFayaqqaIHLGVSEYILKPVAVGELAQSLK 116
Cdd:PRK11091  602 plvaltANVLKDKKEY------LDAGMDDVLSKPLSVPALTAMIK 640
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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