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Conserved domains on  [gi|1778186797|ref|WP_154666908|]
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LuxR C-terminal-related transcriptional regulator [Chania multitudinisentens]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10677008)

helix-turn-helix (HTH) transcriptional regulator containing a LuxR family HTH DNA-binding domain; may act as a transcription activator/repressor, or have a dual role for different sites

Gene Ontology:  GO:0006355|GO:0003677|GO:0003700
PubMed:  15808743|19076237|10473770|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 146-194 1.96e-12

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


:

Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 60.62  E-value: 1.96e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1778186797  146 RSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRS 194
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRS 50
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
88-199 4.97e-11

DNA-binding transcriptional regulator, CsgD family [Transcription];


:

Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 60.15  E-value: 4.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778186797  88 VLLIVDVMFIGGMTRYLLGLKNTKAVLDVSASLEILQNQLLNFFQPCMELDTSNHNTERSLSLREMNVLRRLLEGQSSTS 167
Cdd:COG2771    68 LLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKE 147

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1778186797 168 IARDLQLSPKTISHYKRSALIKLGIRSLQPLM 199
Cdd:COG2771   148 IARILGISERTVRTHLKRIYRKLGVSSRAELV 179
 
Name Accession Description Interval E-value
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 146-194 1.96e-12

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 60.62  E-value: 1.96e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1778186797  146 RSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRS 194
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRS 50
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
88-199 4.97e-11

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 60.15  E-value: 4.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778186797  88 VLLIVDVMFIGGMTRYLLGLKNTKAVLDVSASLEILQNQLLNFFQPCMELDTSNHNTERSLSLREMNVLRRLLEGQSSTS 167
Cdd:COG2771    68 LLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKE 147

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1778186797 168 IARDLQLSPKTISHYKRSALIKLGIRSLQPLM 199
Cdd:COG2771   148 IARILGISERTVRTHLKRIYRKLGVSSRAELV 179
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 144-194 1.29e-10

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 57.59  E-value: 1.29e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1778186797 144 TERSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRS 194
Cdd:COG2197    66 LRRLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRN 116
GerE pfam00196
Bacterial regulatory proteins, luxR family;
147-198 6.78e-10

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 53.74  E-value: 6.78e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1778186797 147 SLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRSLQPL 198
Cdd:pfam00196   2 SLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVEL 53
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 148-196 2.83e-09

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 51.77  E-value: 2.83e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1778186797 148 LSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRSLQ 196
Cdd:cd06170     1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRT 49
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
132-207 7.75e-07

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 48.35  E-value: 7.75e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1778186797 132 QPCMELdTSNHNTERSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRSLQPLMINDHSKKI 207
Cdd:PRK09958  129 RFVGSL-TSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKI 203
PRK09483 PRK09483
response regulator; Provisional
 79-192 4.67e-05

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 43.17  E-value: 4.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778186797  79 ILRYHPNSKVLLI---------VDVMFIGGmTRYLlglknTK---------AVLDVSA-----SLEILQNQLLNFFQPCM 135
Cdd:PRK09483   69 ILRYTPDVKIIMLtvhtenplpAKVMQAGA-AGYL-----SKgaapqevvsAIRSVHSgqryiASDIAQQMALSQIEPAT 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1778186797 136 EldtsnhNTERSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGI 192
Cdd:PRK09483  143 E------NPFASLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNI 193
 
Name Accession Description Interval E-value
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 146-194 1.96e-12

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 60.62  E-value: 1.96e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1778186797  146 RSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRS 194
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRS 50
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
88-199 4.97e-11

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 60.15  E-value: 4.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778186797  88 VLLIVDVMFIGGMTRYLLGLKNTKAVLDVSASLEILQNQLLNFFQPCMELDTSNHNTERSLSLREMNVLRRLLEGQSSTS 167
Cdd:COG2771    68 LLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKE 147

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1778186797 168 IARDLQLSPKTISHYKRSALIKLGIRSLQPLM 199
Cdd:COG2771   148 IARILGISERTVRTHLKRIYRKLGVSSRAELV 179
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 144-194 1.29e-10

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 57.59  E-value: 1.29e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1778186797 144 TERSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRS 194
Cdd:COG2197    66 LRRLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRN 116
GerE pfam00196
Bacterial regulatory proteins, luxR family;
147-198 6.78e-10

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 53.74  E-value: 6.78e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1778186797 147 SLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRSLQPL 198
Cdd:pfam00196   2 SLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVEL 53
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 148-196 2.83e-09

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 51.77  E-value: 2.83e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1778186797 148 LSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRSLQ 196
Cdd:cd06170     1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRT 49
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 147-195 1.30e-08

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 53.18  E-value: 1.30e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1778186797 147 SLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRSL 195
Cdd:COG4566   137 SLTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSL 185
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 144-194 3.37e-07

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 46.88  E-value: 3.37e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1778186797 144 TERSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRS 194
Cdd:COG5905     9 HPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRN 59
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
132-207 7.75e-07

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 48.35  E-value: 7.75e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1778186797 132 QPCMELdTSNHNTERSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRSLQPLMINDHSKKI 207
Cdd:PRK09958  129 RFVGSL-TSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKI 203
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 135-192 4.53e-06

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 46.37  E-value: 4.53e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1778186797 135 MELDTSNHNTERSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGI 192
Cdd:PRK10840  138 LEKISAGGYGDKRLSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGV 195
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 113-194 1.49e-05

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 44.74  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778186797 113 VLDVSASLEILQNQLLNFFQPCMELDTSNHN-----TERSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSAL 187
Cdd:PRK11475   95 VLSKASTLEILQQELFLSLNGVRQATDRLNNqwyinQSRMLSPTEREILRFMSRGYSMPQIAEQLERNIKTIRAHKFNVM 174


                  ....*..
gi 1778186797 188 IKLGIRS 194
Cdd:PRK11475  175 SKLGVSS 181
fixJ PRK09390
response regulator FixJ; Provisional
 147-198 3.02e-05

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 43.84  E-value: 3.02e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1778186797 147 SLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRSLQPL 198
Cdd:PRK09390  141 SLSERERQVMDGLVAGLSNKVIARDLDISPRTVEVYRANVMTKMQAGSLSEL 192
PRK09483 PRK09483
response regulator; Provisional
 79-192 4.67e-05

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 43.17  E-value: 4.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778186797  79 ILRYHPNSKVLLI---------VDVMFIGGmTRYLlglknTK---------AVLDVSA-----SLEILQNQLLNFFQPCM 135
Cdd:PRK09483   69 ILRYTPDVKIIMLtvhtenplpAKVMQAGA-AGYL-----SKgaapqevvsAIRSVHSgqryiASDIAQQMALSQIEPAT 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1778186797 136 EldtsnhNTERSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGI 192
Cdd:PRK09483  143 E------NPFASLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNI 193
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
140-199 1.41e-04

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 41.79  E-value: 1.41e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778186797 140 SNHNTERSLSLREMNVLRRLLEGQSSTSIARDLQLSPKTISHYKRSALIKLGIRSLQPLM 199
Cdd:PRK09935  142 TNSSTDTVLSNREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELI 201
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
157-194 6.40e-03

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 36.61  E-value: 6.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1778186797 157 RRLL-EGQSSTSIARDLQLSPKTISHYKRSALIKLGIRS 194
Cdd:COG2909   131 RRLLaEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRS 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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