Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal ...
59-254
9.89e-99
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.
:
Pssm-ID: 239819 [Multi-domain] Cd Length: 198 Bit Score: 290.82 E-value: 9.89e-99
Bacterial pre-peptidase C-terminal domain; This domain is normally found at the C-terminus of ...
281-344
7.58e-03
Bacterial pre-peptidase C-terminal domain; This domain is normally found at the C-terminus of secreted bacterial peptidases. They are not present in the active peptidase. It is possible that they fulfill a similar role to the PKD (pfam00801) domain, which also are found in this context. Visual analysis suggests that PKD and PPC are distantly related (personal obs:Bateman A, Yeats C).
:
Pssm-ID: 427748 [Multi-domain] Cd Length: 68 Bit Score: 34.55 E-value: 7.58e-03
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal ...
59-254
9.89e-99
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.
Pssm-ID: 239819 [Multi-domain] Cd Length: 198 Bit Score: 290.82 E-value: 9.89e-99
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
59-253
5.83e-06
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.
Pssm-ID: 426242 [Multi-domain] Cd Length: 192 Bit Score: 46.51 E-value: 5.83e-06
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
59-210
1.22e-04
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.
Pssm-ID: 214576 [Multi-domain] Cd Length: 139 Bit Score: 41.57 E-value: 1.22e-04
Bacterial pre-peptidase C-terminal domain; This domain is normally found at the C-terminus of ...
281-344
7.58e-03
Bacterial pre-peptidase C-terminal domain; This domain is normally found at the C-terminus of secreted bacterial peptidases. They are not present in the active peptidase. It is possible that they fulfill a similar role to the PKD (pfam00801) domain, which also are found in this context. Visual analysis suggests that PKD and PPC are distantly related (personal obs:Bateman A, Yeats C).
Pssm-ID: 427748 [Multi-domain] Cd Length: 68 Bit Score: 34.55 E-value: 7.58e-03
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal ...
59-254
9.89e-99
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.
Pssm-ID: 239819 [Multi-domain] Cd Length: 198 Bit Score: 290.82 E-value: 9.89e-99
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
75-253
7.91e-07
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.
Pssm-ID: 238124 [Multi-domain] Cd Length: 167 Bit Score: 48.67 E-value: 7.91e-07
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
59-253
5.83e-06
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.
Pssm-ID: 426242 [Multi-domain] Cd Length: 192 Bit Score: 46.51 E-value: 5.83e-06
Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of ...
79-222
3.67e-05
Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to yield the active protease domain, which is consequently always found at the N-terminus in multi-domain architectures. This family includes: astacin, a digestive enzyme from Crayfish; meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain, proteins involved in (bone) morphogenesis, tolloid from drosophila, and the sea urchin SPAN protein, which may also play a role in development.
Pssm-ID: 239807 [Multi-domain] Cd Length: 180 Bit Score: 43.71 E-value: 3.67e-05
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
75-253
8.66e-05
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.
Pssm-ID: 239796 [Multi-domain] Cd Length: 165 Bit Score: 42.48 E-value: 8.66e-05
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
59-210
1.22e-04
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.
Pssm-ID: 214576 [Multi-domain] Cd Length: 139 Bit Score: 41.57 E-value: 1.22e-04
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
82-189
5.32e-03
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.
Pssm-ID: 239806 [Multi-domain] Cd Length: 156 Bit Score: 37.05 E-value: 5.32e-03
Bacterial pre-peptidase C-terminal domain; This domain is normally found at the C-terminus of ...
281-344
7.58e-03
Bacterial pre-peptidase C-terminal domain; This domain is normally found at the C-terminus of secreted bacterial peptidases. They are not present in the active peptidase. It is possible that they fulfill a similar role to the PKD (pfam00801) domain, which also are found in this context. Visual analysis suggests that PKD and PPC are distantly related (personal obs:Bateman A, Yeats C).
Pssm-ID: 427748 [Multi-domain] Cd Length: 68 Bit Score: 34.55 E-value: 7.58e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
Click on the triangle for interactive 3D structure viewing options.
Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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