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Conserved domains on  [gi|1788976775|ref|WP_158113765|]
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hypothetical protein [Staphylococcus epidermidis]

Protein Classification

dermokine superfamily-containing protein( domain architecture ID 1905135)

dermokine superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dermokine super family cl42387
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 779-936 3.39e-04

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


The actual alignment was detected with superfamily member cd21118:

Pssm-ID: 455732 [Multi-domain]  Cd Length: 495  Bit Score: 44.61  E-value: 3.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788976775  779 REVGATSASNAASGMNKGMMGATWN--AATTPSEWASHGVNYVTNKTTDNSKGNNNNTGGESANAFAARQGGSSNTGRTG 856
Cdd:cd21118    198 QNSGCTNPPPSGSHESFSNSGGSSSsgSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSGNSGGSNGGSSGNSGSGS 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788976775  857 TARSTLlGSQNPNPSNSQNPYGG----NNYFVGARQPMVGSPASITNKGTNGQKPTDPENHKRNNQYKNTA-NTLPSAMK 931
Cdd:cd21118    278 GGSSSG-GSNGWGGSSSSGGSGGsgggNKPECNNPGNDVRMAGGGGSQGSKESSGSHGSNGGNGQAEAVGGlNTLNSDAS 356


                   ....*
gi 1788976775  932 SGSAN 936
Cdd:cd21118    357 TLPFN 361
 
Name Accession Description Interval E-value
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 779-936 3.39e-04

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 44.61  E-value: 3.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788976775  779 REVGATSASNAASGMNKGMMGATWN--AATTPSEWASHGVNYVTNKTTDNSKGNNNNTGGESANAFAARQGGSSNTGRTG 856
Cdd:cd21118    198 QNSGCTNPPPSGSHESFSNSGGSSSsgSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSGNSGGSNGGSSGNSGSGS 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788976775  857 TARSTLlGSQNPNPSNSQNPYGG----NNYFVGARQPMVGSPASITNKGTNGQKPTDPENHKRNNQYKNTA-NTLPSAMK 931
Cdd:cd21118    278 GGSSSG-GSNGWGGSSSSGGSGGsgggNKPECNNPGNDVRMAGGGGSQGSKESSGSHGSNGGNGQAEAVGGlNTLNSDAS 356


                   ....*
gi 1788976775  932 SGSAN 936
Cdd:cd21118    357 TLPFN 361
 
Name Accession Description Interval E-value
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 779-936 3.39e-04

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 44.61  E-value: 3.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788976775  779 REVGATSASNAASGMNKGMMGATWN--AATTPSEWASHGVNYVTNKTTDNSKGNNNNTGGESANAFAARQGGSSNTGRTG 856
Cdd:cd21118    198 QNSGCTNPPPSGSHESFSNSGGSSSsgSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSGNSGGSNGGSSGNSGSGS 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788976775  857 TARSTLlGSQNPNPSNSQNPYGG----NNYFVGARQPMVGSPASITNKGTNGQKPTDPENHKRNNQYKNTA-NTLPSAMK 931
Cdd:cd21118    278 GGSSSG-GSNGWGGSSSSGGSGGsgggNKPECNNPGNDVRMAGGGGSQGSKESSGSHGSNGGNGQAEAVGGlNTLNSDAS 356


                   ....*
gi 1788976775  932 SGSAN 936
Cdd:cd21118    357 TLPFN 361
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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