|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15074 |
PRK15074 |
inosine/guanosine kinase; Provisional |
1-434 |
0e+00 |
|
inosine/guanosine kinase; Provisional
Pssm-ID: 185033 Cd Length: 434 Bit Score: 942.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 1 MKFPGQRKSKHYFPIHARDPLVNQIQQTPKLRHPTVVGVGQTIVDIEARVDDAFLAKYQLSKGHSLVLEESQADALYEEL 80
Cdd:PRK15074 1 MKFPGQRKSKHYFPVNARDPLLQQIQPENETSRTYIVGIDQTLVDIEAKVDDEFLERYGLSKGHSLVIEDDVAEALYQEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 81 IERKLITHLYPGDTIGNTLHNYSVLADSKSVLLGVMSKNIEVSSYAYRYLCQTSSRMNLNHLQTVDGPIGRCYTLISEDG 160
Cdd:PRK15074 81 KQNNLITHEFAGGTIGNTLHNYSVLADDRSVLLGVMSSNIEIGSYAYRYLCNTSSRTDLNYLQGVDGPIGRCFTLISEDG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 161 ERTFAINEGHMNKLRAESIPEEVFAKASALVVSSYLMRGKAEDPMPQAVQRAIGLAKAHHVPVVLTLGTKYVIEGNQTWW 240
Cdd:PRK15074 161 ERTFAISPGHMNQLRPESIPEDVIAGASALVLTAYLVRCKPGEPMPEATMKAIEYAKKHNVPVVLTLGTKFVIEDNPQWW 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 241 QEYLKQHVTVLAMNEEEGEALTGEKDPLLAANKALDWVDLVLCTAGPVGLYMAGYVDDSAKRDTELPLLPGNIPEFNRYE 320
Cdd:PRK15074 241 QEFLKEHVSILAMNEDEAEALTGESDPLLASDKALDWVDLVLCTAGPIGLYMAGYTEDEAKRETQHPLLPGAIAEFNRYE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 321 FSRAMRKEDCQQPVKVYSHIGPYLGGPLEIKNTNGAGDGALSALLHDMAANRYHQNNVPNSAKHALPYLTYSSLSQVCRY 400
Cdd:PRK15074 321 FSRAMRKKDCQNPLRVYSHIAPYMGGPEKIMNTNGAGDGALSALLHDITANSYHRSNVPNSSKHKRTYLTYSSLAQVCKY 400
|
410 420 430
....*....|....*....|....*....|....
gi 1789005889 401 ANRVSYEVLTQHSPRLSSSLPEREDSLEEAYWDR 434
Cdd:PRK15074 401 ANRVSYEVLNQHSPRLSRGLPEREDSLEESYWER 434
|
|
| RbsK |
COG0524 |
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar ... |
36-425 |
1.04e-36 |
|
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar or nucleoside kinase, ribokinase family is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440290 [Multi-domain] Cd Length: 301 Bit Score: 136.17 E-value: 1.04e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 36 VVGVGQTIVDIEARVDDaflakyqLSKGHSLVLEESqadalyeelierkliTHLYPGDTIGNTLHNYSVLaDSKSVLLGV 115
Cdd:COG0524 2 VLVIGEALVDLVARVDR-------LPKGGETVLAGS---------------FRRSPGGAAANVAVALARL-GARVALVGA 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 116 MSKNiEVSSYAYRYLcqTSSRMNLNHLQTVDG-PIGRCYTLISEDGERTFAINEGHMNKLRAESIPEEVFAKASALVVSS 194
Cdd:COG0524 59 VGDD-PFGDFLLAEL--RAEGVDTSGVRRDPGaPTGLAFILVDPDGERTIVFYRGANAELTPEDLDEALLAGADILHLGG 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 195 YLMrgkAEDPMPQAVQRAIGLAKAHHVPVVLTLGT-KYVIEGNQTWWQEYLKqHVTVLAMNEEEGEALTGEKDPLLAANK 273
Cdd:COG0524 136 ITL---ASEPPREALLAALEAARAAGVPVSLDPNYrPALWEPARELLRELLA-LVDILFPNEEEAELLTGETDPEEAAAA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 274 ALDW-VDLVLCTAGPVGLYmagYVDDSAkrdtelpllpgnipefnryefsramrkedcqqpvkvYSHIGPYlggPLEIKN 352
Cdd:COG0524 212 LLARgVKLVVVTLGAEGAL---LYTGGE------------------------------------VVHVPAF---PVEVVD 249
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1789005889 353 TNGAGDGALSALLHDMAANRyhqnnvpnsakhalpyltysSLSQVCRYANRVSYEVLTQHSPRlsSSLPERED 425
Cdd:COG0524 250 TTGAGDAFAAGFLAGLLEGL--------------------DLEEALRFANAAAALVVTRPGAQ--PALPTREE 300
|
|
| adenosine_kinase |
cd01168 |
Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside ... |
36-417 |
5.08e-27 |
|
Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine levels and the preservation of intracellular adenylate pools. Adenosine kinase is involved in the purine salvage pathway.
Pssm-ID: 238573 [Multi-domain] Cd Length: 312 Bit Score: 110.01 E-value: 5.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 36 VVGVGQTIVDIEARVDDAFLAKYQLSKGHS-LVLEEsqadaLYEELIErKLITHLYPGDTIGNTLHNYSVLADSkSVLLG 114
Cdd:cd01168 4 VLGLGNALVDILAQVDDAFLEKLGLKKGDMiLADME-----EQEELLA-KLPVKYIAGGSAANTIRGAAALGGS-AAFIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 115 VMSKNievsSYAYRYLcQTSSRMNLN-HLQTV-DGPIGRCYTLISEDGERTFAINEGHMNKLRAESIPEEVFAKASALVV 192
Cdd:cd01168 77 RVGDD----KLGDFLL-KDLRAAGVDtRYQVQpDGPTGTCAVLVTPDAERTMCTYLGAANELSPDDLDWSLLAKAKYLYL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 193 SSYLMrgkaeDPMPQAVQRAIGLAKAHHVPVVLTLGTKYVIEGNqtwwQEYLKQ---HVTVLAMNEEEGEALTG--EKDP 267
Cdd:cd01168 152 EGYLL-----TVPPEAILLAAEHAKENGVKIALNLSAPFIVQRF----KEALLEllpYVDILFGNEEEAEALAEaeTTDD 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 268 LLAANKAL-DWVDLVLCTAGPVGLYMAgyvddsakrdtelpllpgnipefnryefsramrkedcqQPVKVYsHIGPYlgG 346
Cdd:cd01168 223 LEAALKLLaLRCRIVVITQGAKGAVVV--------------------------------------EGGEVY-PVPAI--P 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1789005889 347 PLEIKNTNGAGD----GALSALLHDMaanryhqnnvpnsakhalpyltysSLSQVCRYANRVSYEVLTQHSPRLS 417
Cdd:cd01168 262 VEKIVDTNGAGDafagGFLYGLVQGE------------------------PLEECIRLGSYAAAEVIQQLGPRLP 312
|
|
| PfkB |
pfam00294 |
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ... |
141-416 |
4.05e-10 |
|
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases.
Pssm-ID: 425587 [Multi-domain] Cd Length: 294 Bit Score: 60.43 E-value: 4.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 141 HLQTVDGPIGRCYTLISEDGERTFAINEGHMNKLRAE--SIPEEVFAKASALVVSSYLMRGKAEDpmpqAVQRAIGLAKA 218
Cdd:pfam00294 80 VVIDEDTRTGTALIEVDGDGERTIVFNRGAAADLTPEelEENEDLLENADLLYISGSLPLGLPEA----TLEELIEAAKN 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 219 H--HVPVVL--TLGTKYVIegnqtwwQEYLkQHVTVLAMNEEEGEALTGEKDP----LLAANKALDW--VDLVLCTAGPV 288
Cdd:pfam00294 156 GgtFDPNLLdpLGAAREAL-------LELL-PLADLLKPNEEELEALTGAKLDdieeALAALHKLLAkgIKTVIVTLGAD 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 289 GLYmagYVDdsakRDTELPLLPgnipefnryefsramrkedcQQPVKVYShigpylggpleiknTNGAGD----GALSAL 364
Cdd:pfam00294 228 GAL---VVE----GDGEVHVPA--------------------VPKVKVVD--------------TTGAGDsfvgGFLAGL 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1789005889 365 LHDMaanryhqnnvpnsakhalpyltysSLSQVCRYANRVSYEVLTQHSPRL 416
Cdd:pfam00294 267 LAGK------------------------SLEEALRFANAAAALVVQKSGAQT 294
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15074 |
PRK15074 |
inosine/guanosine kinase; Provisional |
1-434 |
0e+00 |
|
inosine/guanosine kinase; Provisional
Pssm-ID: 185033 Cd Length: 434 Bit Score: 942.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 1 MKFPGQRKSKHYFPIHARDPLVNQIQQTPKLRHPTVVGVGQTIVDIEARVDDAFLAKYQLSKGHSLVLEESQADALYEEL 80
Cdd:PRK15074 1 MKFPGQRKSKHYFPVNARDPLLQQIQPENETSRTYIVGIDQTLVDIEAKVDDEFLERYGLSKGHSLVIEDDVAEALYQEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 81 IERKLITHLYPGDTIGNTLHNYSVLADSKSVLLGVMSKNIEVSSYAYRYLCQTSSRMNLNHLQTVDGPIGRCYTLISEDG 160
Cdd:PRK15074 81 KQNNLITHEFAGGTIGNTLHNYSVLADDRSVLLGVMSSNIEIGSYAYRYLCNTSSRTDLNYLQGVDGPIGRCFTLISEDG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 161 ERTFAINEGHMNKLRAESIPEEVFAKASALVVSSYLMRGKAEDPMPQAVQRAIGLAKAHHVPVVLTLGTKYVIEGNQTWW 240
Cdd:PRK15074 161 ERTFAISPGHMNQLRPESIPEDVIAGASALVLTAYLVRCKPGEPMPEATMKAIEYAKKHNVPVVLTLGTKFVIEDNPQWW 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 241 QEYLKQHVTVLAMNEEEGEALTGEKDPLLAANKALDWVDLVLCTAGPVGLYMAGYVDDSAKRDTELPLLPGNIPEFNRYE 320
Cdd:PRK15074 241 QEFLKEHVSILAMNEDEAEALTGESDPLLASDKALDWVDLVLCTAGPIGLYMAGYTEDEAKRETQHPLLPGAIAEFNRYE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 321 FSRAMRKEDCQQPVKVYSHIGPYLGGPLEIKNTNGAGDGALSALLHDMAANRYHQNNVPNSAKHALPYLTYSSLSQVCRY 400
Cdd:PRK15074 321 FSRAMRKKDCQNPLRVYSHIAPYMGGPEKIMNTNGAGDGALSALLHDITANSYHRSNVPNSSKHKRTYLTYSSLAQVCKY 400
|
410 420 430
....*....|....*....|....*....|....
gi 1789005889 401 ANRVSYEVLTQHSPRLSSSLPEREDSLEEAYWDR 434
Cdd:PRK15074 401 ANRVSYEVLNQHSPRLSRGLPEREDSLEESYWER 434
|
|
| RbsK |
COG0524 |
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar ... |
36-425 |
1.04e-36 |
|
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar or nucleoside kinase, ribokinase family is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440290 [Multi-domain] Cd Length: 301 Bit Score: 136.17 E-value: 1.04e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 36 VVGVGQTIVDIEARVDDaflakyqLSKGHSLVLEESqadalyeelierkliTHLYPGDTIGNTLHNYSVLaDSKSVLLGV 115
Cdd:COG0524 2 VLVIGEALVDLVARVDR-------LPKGGETVLAGS---------------FRRSPGGAAANVAVALARL-GARVALVGA 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 116 MSKNiEVSSYAYRYLcqTSSRMNLNHLQTVDG-PIGRCYTLISEDGERTFAINEGHMNKLRAESIPEEVFAKASALVVSS 194
Cdd:COG0524 59 VGDD-PFGDFLLAEL--RAEGVDTSGVRRDPGaPTGLAFILVDPDGERTIVFYRGANAELTPEDLDEALLAGADILHLGG 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 195 YLMrgkAEDPMPQAVQRAIGLAKAHHVPVVLTLGT-KYVIEGNQTWWQEYLKqHVTVLAMNEEEGEALTGEKDPLLAANK 273
Cdd:COG0524 136 ITL---ASEPPREALLAALEAARAAGVPVSLDPNYrPALWEPARELLRELLA-LVDILFPNEEEAELLTGETDPEEAAAA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 274 ALDW-VDLVLCTAGPVGLYmagYVDDSAkrdtelpllpgnipefnryefsramrkedcqqpvkvYSHIGPYlggPLEIKN 352
Cdd:COG0524 212 LLARgVKLVVVTLGAEGAL---LYTGGE------------------------------------VVHVPAF---PVEVVD 249
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1789005889 353 TNGAGDGALSALLHDMAANRyhqnnvpnsakhalpyltysSLSQVCRYANRVSYEVLTQHSPRlsSSLPERED 425
Cdd:COG0524 250 TTGAGDAFAAGFLAGLLEGL--------------------DLEEALRFANAAAALVVTRPGAQ--PALPTREE 300
|
|
| adenosine_kinase |
cd01168 |
Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside ... |
36-417 |
5.08e-27 |
|
Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine levels and the preservation of intracellular adenylate pools. Adenosine kinase is involved in the purine salvage pathway.
Pssm-ID: 238573 [Multi-domain] Cd Length: 312 Bit Score: 110.01 E-value: 5.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 36 VVGVGQTIVDIEARVDDAFLAKYQLSKGHS-LVLEEsqadaLYEELIErKLITHLYPGDTIGNTLHNYSVLADSkSVLLG 114
Cdd:cd01168 4 VLGLGNALVDILAQVDDAFLEKLGLKKGDMiLADME-----EQEELLA-KLPVKYIAGGSAANTIRGAAALGGS-AAFIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 115 VMSKNievsSYAYRYLcQTSSRMNLN-HLQTV-DGPIGRCYTLISEDGERTFAINEGHMNKLRAESIPEEVFAKASALVV 192
Cdd:cd01168 77 RVGDD----KLGDFLL-KDLRAAGVDtRYQVQpDGPTGTCAVLVTPDAERTMCTYLGAANELSPDDLDWSLLAKAKYLYL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 193 SSYLMrgkaeDPMPQAVQRAIGLAKAHHVPVVLTLGTKYVIEGNqtwwQEYLKQ---HVTVLAMNEEEGEALTG--EKDP 267
Cdd:cd01168 152 EGYLL-----TVPPEAILLAAEHAKENGVKIALNLSAPFIVQRF----KEALLEllpYVDILFGNEEEAEALAEaeTTDD 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 268 LLAANKAL-DWVDLVLCTAGPVGLYMAgyvddsakrdtelpllpgnipefnryefsramrkedcqQPVKVYsHIGPYlgG 346
Cdd:cd01168 223 LEAALKLLaLRCRIVVITQGAKGAVVV--------------------------------------EGGEVY-PVPAI--P 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1789005889 347 PLEIKNTNGAGD----GALSALLHDMaanryhqnnvpnsakhalpyltysSLSQVCRYANRVSYEVLTQHSPRLS 417
Cdd:cd01168 262 VEKIVDTNGAGDafagGFLYGLVQGE------------------------PLEECIRLGSYAAAEVIQQLGPRLP 312
|
|
| PLN02813 |
PLN02813 |
pfkB-type carbohydrate kinase family protein |
36-428 |
2.02e-13 |
|
pfkB-type carbohydrate kinase family protein
Pssm-ID: 215434 [Multi-domain] Cd Length: 426 Bit Score: 71.76 E-value: 2.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 36 VVGVGQTIVDIEARVDDAFLAKYQLSKGHSLVLEESQADALYEELIERKliTHLYPGDTIGNTLHNYSVLADSKS----- 110
Cdd:PLN02813 72 VLGLGQAMVDFSGMVDDEFLERLGLEKGTRKVINHEERGKVLRALDGCS--YKASAGGSLSNTLVALARLGSQSAagpal 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 111 -VLLGVMSKNIEVSSYaYRYLCQtssRMNLNHLQ--TVDGPIGRCYTLISEDGERTFAINEGHMNKLRAESIPEEVFAKA 187
Cdd:PLN02813 150 nVAMAGSVGSDPLGDF-YRTKLR---RANVHFLSqpVKDGTTGTVIVLTTPDAQRTMLSYQGTSSTVNYDSCLASAISKS 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 188 SALVVSSYLMRgkaedpMPQAVQ---RAIGLAKAHHVPVVLTLGTKYVIEGNQTWWQEYLKQHVTVLAMNEEEGEALTG- 263
Cdd:PLN02813 226 RVLVVEGYLWE------LPQTIEaiaQACEEAHRAGALVAVTASDVSCIERHRDDFWDVMGNYADILFANSDEARALCGl 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 264 -EKDPLLAANKAL-DWVDLVLCTAGPVGLYMAgyvddsakrdtelplLPGNIpefnryefsramrkedcqqpvkVYshIG 341
Cdd:PLN02813 300 gSEESPESATRYLsHFCPLVSVTDGARGSYIG---------------VKGEA----------------------VY--IP 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 342 PYLGGPLEiknTNGAGDGALSALLHDMAANryhqnnvpnsakhalpyltYSSLSQVCRYANRVSYEVLTQHSPRLS---- 417
Cdd:PLN02813 341 PSPCVPVD---TCGAGDAYAAGILYGLLRG-------------------VSDLRGMGELAARVAATVVGQQGTRLRveda 398
|
410
....*....|....*
gi 1789005889 418 ----SSLPEREDSLE 428
Cdd:PLN02813 399 velaESFALHLDGSD 413
|
|
| ribokinase_pfkB_like |
cd00287 |
ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including ... |
183-369 |
1.29e-11 |
|
ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-dehydro-3-deoxygluconokinase, 1-phosphofructokinase, the minor 6-phosphofructokinase (PfkB), inosine-guanosine kinase, and adenosine kinase. Even though there is a high degree of structural conservation within this superfamily, their multimerization level varies widely, monomeric (e.g. adenosine kinase), dimeric (e.g. ribokinase), and trimeric (e.g THZ kinase).
Pssm-ID: 238177 [Multi-domain] Cd Length: 196 Bit Score: 63.27 E-value: 1.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 183 VFAKASALVVSSYlmrgkaeDPMPQAVQRAIGLAKAHHVPVVLTLGTKYVIEGNQTwwQEYLKQHVTVLAMNEEEGEALT 262
Cdd:cd00287 54 TLVGADAVVISGL-------SPAPEAVLDALEEARRRGVPVVLDPGPRAVRLDGEE--LEKLLPGVDILTPNEEEAEALT 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 263 GEKDPL------LAANKALDWVDLVLCTAGPVGLYMAgyvddsAKRDTELPllpgnIPEFnryefsramrkedcqqpvkv 336
Cdd:cd00287 125 GRRDLEvkeaaeAAALLLSKGPKVVIVTLGEKGAIVA------TRGGTEVH-----VPAF-------------------- 173
|
170 180 190
....*....|....*....|....*....|...
gi 1789005889 337 yshigpylggPLEIKNTNGAGDGALSALLHDMA 369
Cdd:cd00287 174 ----------PVKVVDTTGAGDAFLAALAAGLA 196
|
|
| PfkB |
pfam00294 |
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ... |
141-416 |
4.05e-10 |
|
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases.
Pssm-ID: 425587 [Multi-domain] Cd Length: 294 Bit Score: 60.43 E-value: 4.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 141 HLQTVDGPIGRCYTLISEDGERTFAINEGHMNKLRAE--SIPEEVFAKASALVVSSYLMRGKAEDpmpqAVQRAIGLAKA 218
Cdd:pfam00294 80 VVIDEDTRTGTALIEVDGDGERTIVFNRGAAADLTPEelEENEDLLENADLLYISGSLPLGLPEA----TLEELIEAAKN 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 219 H--HVPVVL--TLGTKYVIegnqtwwQEYLkQHVTVLAMNEEEGEALTGEKDP----LLAANKALDW--VDLVLCTAGPV 288
Cdd:pfam00294 156 GgtFDPNLLdpLGAAREAL-------LELL-PLADLLKPNEEELEALTGAKLDdieeALAALHKLLAkgIKTVIVTLGAD 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 289 GLYmagYVDdsakRDTELPLLPgnipefnryefsramrkedcQQPVKVYShigpylggpleiknTNGAGD----GALSAL 364
Cdd:pfam00294 228 GAL---VVE----GDGEVHVPA--------------------VPKVKVVD--------------TTGAGDsfvgGFLAGL 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1789005889 365 LHDMaanryhqnnvpnsakhalpyltysSLSQVCRYANRVSYEVLTQHSPRL 416
Cdd:pfam00294 267 LAGK------------------------SLEEALRFANAAAALVVQKSGAQT 294
|
|
| PTZ00247 |
PTZ00247 |
adenosine kinase; Provisional |
34-287 |
2.43e-07 |
|
adenosine kinase; Provisional
Pssm-ID: 240328 [Multi-domain] Cd Length: 345 Bit Score: 52.34 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 34 PTVVGVGQTIVDIEARVDDAFLAKYQLSKGHSLVLEESQAdALYEELIERKLITHLyPGdtiGNTLHNYSVLA----DSK 109
Cdd:PTZ00247 6 KKLLGFGNPLLDISAHVSDEFLEKYGLELGSAILAEEKQL-PIFEELESIPNVSYV-PG---GSALNTARVAQwmlqAPK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 110 S--VLLGVMSKNievssyayRY---LCQTSSRMNLNHL--QTVDGPIGRCYTLISeDGERTFAINEGHMNKLRAESI--- 179
Cdd:PTZ00247 81 GfvCYVGCVGDD--------RFaeiLKEAAEKDGVEMLfeYTTKAPTGTCAVLVC-GKERSLVANLGAANHLSAEHMqsh 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 180 -PEEVFAKASALVVSSYLMrgkaeDPMPQAVQRAIGLAKAHHVPVVLTLGTKYVIegnQTWWQEYLK--QHVTVLAMNEE 256
Cdd:PTZ00247 152 aVQEAIKTAQLYYLEGFFL-----TVSPNNVLQVAKHARESGKLFCLNLSAPFIS---QFFFERLLQvlPYVDILFGNEE 223
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1789005889 257 EGEALT-----GEKDPLLAANKALDWVD-------LVLCTAGP 287
Cdd:PTZ00247 224 EAKTFAkamkwDTEDLKEIAARIAMLPKysgtrprLVVFTQGP 266
|
|
| ribokinase |
cd01174 |
Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This ... |
143-294 |
2.49e-06 |
|
Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.
Pssm-ID: 238579 [Multi-domain] Cd Length: 292 Bit Score: 49.09 E-value: 2.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 143 QTVDGPIGRCYTLISEDGERTFAINEGHMNKLRAESIP--EEVFAKASALVVssylmrgKAEDPMPqAVQRAIGLAKAHH 220
Cdd:cd01174 84 VVVGAPTGTAVITVDESGENRIVVVPGANGELTPADVDaaLELIAAADVLLL-------QLEIPLE-TVLAALRAARRAG 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 221 VPVVLtlgtkyviegN----QTWWQEYLKqHVTVLAMNEEEGEALTG-----EKDPLLAANKALDW-VDLVLCTAGPVG- 289
Cdd:cd01174 156 VTVIL----------NpapaRPLPAELLA-LVDILVPNETEAALLTGievtdEEDAEKAARLLLAKgVKNVIVTLGAKGa 224
|
....*
gi 1789005889 290 LYMAG 294
Cdd:cd01174 225 LLASG 229
|
|
| PLN02379 |
PLN02379 |
pfkB-type carbohydrate kinase family protein |
31-267 |
3.49e-06 |
|
pfkB-type carbohydrate kinase family protein
Pssm-ID: 178005 [Multi-domain] Cd Length: 367 Bit Score: 49.02 E-value: 3.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 31 LRHPTVVGVGQT-IVDIEARVDDAFLAKYQLSKGHSLVLEESQADALYEELIERKLI--THLYP-----GDTIGNTLHNY 102
Cdd:PLN02379 17 PRPPLVLGLQPVaLVDHVARVDWSLLDQIPGDRGGSIRVTIEELEHILREVNAHILPspDDLSPiktmaGGSVANTIRGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 103 SVLADSKSVLLGVMSKNIE----VSSYAyrylcqtSSRMNLNHLQTVDGPIGRCYTLISEDGERTFAINEGHMNKLRAES 178
Cdd:PLN02379 97 SAGFGVSTGIIGACGDDEQgklfVSNMG-------FSGVDLSRLRAKKGPTAQCVCLVDALGNRTMRPCLSSAVKLQADE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 179 IPEEVFaKASALVVSSYLMRGKaedpmpQAVQRAIGLAKAHHVPVVLTLGTKYVIEGNQTWWQEYLKQ-HVTVLAMNEEE 257
Cdd:PLN02379 170 LTKEDF-KGSKWLVLRYGFYNL------EVIEAAIRLAKQEGLSVSLDLASFEMVRNFRSPLLQLLESgKIDLCFANEDE 242
|
250
....*....|.
gi 1789005889 258 G-EALTGEKDP 267
Cdd:PLN02379 243 ArELLRGEQES 253
|
|
| PRK11142 |
PRK11142 |
ribokinase; Provisional |
156-291 |
3.88e-05 |
|
ribokinase; Provisional
Pssm-ID: 236858 [Multi-domain] Cd Length: 306 Bit Score: 45.25 E-value: 3.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 156 ISEDGERTFAINEGHMNKLRAESIP--EEVFAKASALvvssyLMrgKAEDPMPqAVQRAIGLAKAHHVPVVL------TL 227
Cdd:PRK11142 100 VNDEGENSIGIHAGANAALTPALVEahRELIANADAL-----LM--QLETPLE-TVLAAAKIAKQHGTKVILnpaparEL 171
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789005889 228 GTkyviegnqtwwqEYLKQhVTVLAMNEEEGEALTG-----EKDPLLAANKALDW-VDLVLCTAGPVGLY 291
Cdd:PRK11142 172 PD------------ELLAL-VDIITPNETEAEKLTGirvedDDDAAKAAQVLHQKgIETVLITLGSRGVW 228
|
|
| PLN02548 |
PLN02548 |
adenosine kinase |
40-83 |
6.24e-03 |
|
adenosine kinase
Pssm-ID: 178163 [Multi-domain] Cd Length: 332 Bit Score: 38.54 E-value: 6.24e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1789005889 40 GQTIVDIEARVDDAFLAKYQLSKGHSLVLEESQAdALYEELIER 83
Cdd:PLN02548 2 GNPLLDISAVVDQDFLDKYDVKLNNAILAEEKHL-PMYDELASK 44
|
|
| |
