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Conserved domains on  [gi|1789013403|ref|WP_158143522|]
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HD-GYP domain-containing protein [Vibrio fluvialis]

Protein Classification

HD-GYP domain-containing protein( domain architecture ID 11454351)

HD-GYP domain-containing protein functions as a cyclic nucleotide phosphodiesterase, such as Borreliella burgdorferi cyclic di-GMP phosphodiesterase PdeB that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP

CATH:  1.10.3210.10
Gene Ontology:  GO:0004112|GO:0046872
PubMed:  11008484|9868367

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HDGYP COG2206
HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal ...
 149-449 4.65e-71

HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal transduction mechanisms];


:

Pssm-ID: 441808 [Multi-domain]  Cd Length: 316  Bit Score: 227.93  E-value: 4.65e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 149 RELLFSEDVAQGIQHLDEHWDGSGRPDALMHDQIPLFSRIALLAQVMDVFQREHDLNIAFSELENRSGNWLDPNLVAIAK 228
Cdd:COG2206     8 LLLLLLLLLLLALLLLLLLLLLLLLLLLLLLLLALLALLLLLLLLLALLALLLALLALLLLLLLLLLLLSLLLAVALLLA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 229 QLKDNPDFIKALNAPSIVPFVLS-MSPAQAMIPLDDDYFDRIVTAFGKIIDAKSPFTSGHSSRVAIFSTLIAEELKVDKE 307
Cdd:COG2206    88 ELLLLLAALESLLAELFEELRLGlLEELKKLVEELDELLPDALLALLAALDAKDPYTYGHSVRVAVLALALARELGLSEE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 308 DRLWLKRAALLHDLGKLGVSNTILDKPGKLDDDEWAKIQNHAVFTREIIEKISPLKQFAKMAAAHHEKLDGTGYPDKLVA 387
Cdd:COG2206   168 ELEDLGLAALLHDIGKIGIPDEILNKPGKLTDEEFEIIKKHPEYGYEILKKLPGLSEVAEIVLQHHERLDGSGYPRGLKG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1789013403 388 DEISMMTRIITTADIFDAITAERPYRGAVPIPKTLEIMEENVGTAIDPLCFNALKAALNKLP 449
Cdd:COG2206   248 EEIPLLARILAVADVYDALTSDRPYRKALSPEEALEELRKGAGTQFDPELVEAFIKVLGIYP 309
HDGYP COG2206
HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal ...
 12-249 3.53e-16

HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal transduction mechanisms];


:

Pssm-ID: 441808 [Multi-domain]  Cd Length: 316  Bit Score: 79.25  E-value: 3.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403  12 LAELVSSLTVALDMTEGQPPEHSMRCCWIGMHIGERMNLSSSELHDLYFTLLLKDAGcssnaaricelyatddltfkqry 91
Cdd:COG2206   126 LPDALLALLAALDAKDPYTYGHSVRVAVLALALARELGLSEEELEDLGLAALLHDIG----------------------- 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403  92 KTvgtsltsainfvlknagsgehwhkRISTTIdILKNG--TDYAQELIQTRCTKGAEVARELLFSEDVAQGIQHLDEHWD 169
Cdd:COG2206   183 KI------------------------GIPDEI-LNKPGklTDEEFEIIKKHPEYGYEILKKLPGLSEVAEIVLQHHERLD 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 170 GSGRPDALMHDQIPLFSRIALLAQVMD------VFQREHDLNIAFSELENRSGNWLDPNLVAIakqlkdnpdFIKALNAP 243
Cdd:COG2206   238 GSGYPRGLKGEEIPLLARILAVADVYDaltsdrPYRKALSPEEALEELRKGAGTQFDPELVEA---------FIKVLGIY 308


                  ....*.
gi 1789013403 244 SIVPFV 249
Cdd:COG2206   309 PPVVEI 314
 
Name Accession Description Interval E-value
HDGYP COG2206
HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal ...
 149-449 4.65e-71

HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal transduction mechanisms];


Pssm-ID: 441808 [Multi-domain]  Cd Length: 316  Bit Score: 227.93  E-value: 4.65e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 149 RELLFSEDVAQGIQHLDEHWDGSGRPDALMHDQIPLFSRIALLAQVMDVFQREHDLNIAFSELENRSGNWLDPNLVAIAK 228
Cdd:COG2206     8 LLLLLLLLLLLALLLLLLLLLLLLLLLLLLLLLALLALLLLLLLLLALLALLLALLALLLLLLLLLLLLSLLLAVALLLA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 229 QLKDNPDFIKALNAPSIVPFVLS-MSPAQAMIPLDDDYFDRIVTAFGKIIDAKSPFTSGHSSRVAIFSTLIAEELKVDKE 307
Cdd:COG2206    88 ELLLLLAALESLLAELFEELRLGlLEELKKLVEELDELLPDALLALLAALDAKDPYTYGHSVRVAVLALALARELGLSEE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 308 DRLWLKRAALLHDLGKLGVSNTILDKPGKLDDDEWAKIQNHAVFTREIIEKISPLKQFAKMAAAHHEKLDGTGYPDKLVA 387
Cdd:COG2206   168 ELEDLGLAALLHDIGKIGIPDEILNKPGKLTDEEFEIIKKHPEYGYEILKKLPGLSEVAEIVLQHHERLDGSGYPRGLKG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1789013403 388 DEISMMTRIITTADIFDAITAERPYRGAVPIPKTLEIMEENVGTAIDPLCFNALKAALNKLP 449
Cdd:COG2206   248 EEIPLLARILAVADVYDALTSDRPYRKALSPEEALEELRKGAGTQFDPELVEAFIKVLGIYP 309
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 282-425 7.10e-23

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 94.33  E-value: 7.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 282 PFTSGHSSRVAIFSTLIAEELKVDKEDRLWLKRAALLHDLGKLGVSNTIldkpgklDDDEWAKIQNHAVFTREIIEKISP 361
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELGLSEEDIELLRLAALLHDIGKPGTPDAI-------TEEESELEKDHAIVGAEILRELLL 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1789013403 362 LKQFAK-------MAAAHHEKLDGTGYPDKLVADEISMMTRIITTADIFDAITAE-RPYRGAVPIPKTLEIM 425
Cdd:cd00077    74 EEVIKLidelilaVDASHHERLDGLGYPDGLKGEEITLEARIVKLADRLDALRRDsREKRRRIAEEDLEELL 145
HDGYP COG2206
HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal ...
 12-249 3.53e-16

HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal transduction mechanisms];


Pssm-ID: 441808 [Multi-domain]  Cd Length: 316  Bit Score: 79.25  E-value: 3.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403  12 LAELVSSLTVALDMTEGQPPEHSMRCCWIGMHIGERMNLSSSELHDLYFTLLLKDAGcssnaaricelyatddltfkqry 91
Cdd:COG2206   126 LPDALLALLAALDAKDPYTYGHSVRVAVLALALARELGLSEEELEDLGLAALLHDIG----------------------- 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403  92 KTvgtsltsainfvlknagsgehwhkRISTTIdILKNG--TDYAQELIQTRCTKGAEVARELLFSEDVAQGIQHLDEHWD 169
Cdd:COG2206   183 KI------------------------GIPDEI-LNKPGklTDEEFEIIKKHPEYGYEILKKLPGLSEVAEIVLQHHERLD 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 170 GSGRPDALMHDQIPLFSRIALLAQVMD------VFQREHDLNIAFSELENRSGNWLDPNLVAIakqlkdnpdFIKALNAP 243
Cdd:COG2206   238 GSGYPRGLKGEEIPLLARILAVADVYDaltsdrPYRKALSPEEALEELRKGAGTQFDPELVEA---------FIKVLGIY 308


                  ....*.
gi 1789013403 244 SIVPFV 249
Cdd:COG2206   309 PPVVEI 314
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 287-414 3.34e-15

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 71.94  E-value: 3.34e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403  287 HSSRVAIFSTLIAEELKvdKEDRLWLKRAALLHDLGKLGVSNTILDKPGKLDDdewakiqnHAVFTREIIEKISPLKQFA 366
Cdd:smart00471   8 HSLRVAQLAAALAEELG--LLDIELLLLAALLHDIGKPGTPDSFLVKTSVLED--------HHFIGAEILLEEEEPRILE 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1789013403  367 KMA----AAHHEKLDGTGYpdklvaDEISMMTRIITTADIFDAITAERPYRG 414
Cdd:smart00471  78 EILrtaiLSHHERPDGLRG------EPITLEARIVKVADRLDALRADRRYRR 123
HD_5 pfam13487
HD domain; HD domains are metal dependent phosphohydrolases.
 335-397 1.03e-13

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 433249 [Multi-domain]  Cd Length: 64  Bit Score: 65.70  E-value: 1.03e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1789013403 335 GKLDDDEWAKIQNHAVFTREIIEKISPL-KQFAKMAAAHHEKLDGTGYPDKLVADEISMMTRII 397
Cdd:pfam13487   1 GTLTPEEREIINRHPEHTARLLSTLPRLpKEVAEIIAQHHERLDGSGYPRGLKGEEIPLGARIL 64
HDIG TIGR00277
HDIG domain; This domain is found in a few known nucleotidyltransferes and in a large number ...
 287-375 5.20e-06

HDIG domain; This domain is found in a few known nucleotidyltransferes and in a large number of uncharacterized proteins. It contains four widely separated His residues, the second of which is part of an invariant dipeptide His-Asp in a region matched approximately by the motif HDIG. This model may annotate homologous domains in which one or more of the His residues is conserved but misaligned, and some probable false-positive hits.


Pssm-ID: 272994 [Multi-domain]  Cd Length: 80  Bit Score: 44.25  E-value: 5.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 287 HSSRVAIFSTLIAEELKVDKEdrLWlKRAALLHDLgklgvsntildkpGKLDDDEWAKIQNHAVFTREIIEKISPLKQFA 366
Cdd:TIGR00277   8 HSLEVAKLAEALARELGLDVE--LA-RRGALLHDI-------------GKPITREGVIFESHVVVGAEIARKYGEPLEVI 71


                  ....*....
gi 1789013403 367 KMAAAHHEK 375
Cdd:TIGR00277  72 DIIAEHHGK 80
PRK12704 PRK12704
phosphodiesterase; Provisional
 287-415 3.10e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.23  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 287 HSSRVAIFSTLIAEELKVDKEdrlwL-KRAALLHDLGK-----LGVSNTILdkpGKldddEWAKIQN-HAVftreIIEKI 359
Cdd:PRK12704  339 HSIEVAHLAGLMAAELGLDVK----LaKRAGLLHDIGKaldheVEGSHVEI---GA----ELAKKYKeSPV----VINAI 403

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1789013403 360 splkqfakmaAAHHekldgtgypdklvaDEISMMTRIITTADIFDAITAERPyrGA 415
Cdd:PRK12704  404 ----------AAHH--------------GDEEPTSIEAVLVAAADAISAARP--GA 433
 
Name Accession Description Interval E-value
HDGYP COG2206
HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal ...
 149-449 4.65e-71

HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal transduction mechanisms];


Pssm-ID: 441808 [Multi-domain]  Cd Length: 316  Bit Score: 227.93  E-value: 4.65e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 149 RELLFSEDVAQGIQHLDEHWDGSGRPDALMHDQIPLFSRIALLAQVMDVFQREHDLNIAFSELENRSGNWLDPNLVAIAK 228
Cdd:COG2206     8 LLLLLLLLLLLALLLLLLLLLLLLLLLLLLLLLALLALLLLLLLLLALLALLLALLALLLLLLLLLLLLSLLLAVALLLA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 229 QLKDNPDFIKALNAPSIVPFVLS-MSPAQAMIPLDDDYFDRIVTAFGKIIDAKSPFTSGHSSRVAIFSTLIAEELKVDKE 307
Cdd:COG2206    88 ELLLLLAALESLLAELFEELRLGlLEELKKLVEELDELLPDALLALLAALDAKDPYTYGHSVRVAVLALALARELGLSEE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 308 DRLWLKRAALLHDLGKLGVSNTILDKPGKLDDDEWAKIQNHAVFTREIIEKISPLKQFAKMAAAHHEKLDGTGYPDKLVA 387
Cdd:COG2206   168 ELEDLGLAALLHDIGKIGIPDEILNKPGKLTDEEFEIIKKHPEYGYEILKKLPGLSEVAEIVLQHHERLDGSGYPRGLKG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1789013403 388 DEISMMTRIITTADIFDAITAERPYRGAVPIPKTLEIMEENVGTAIDPLCFNALKAALNKLP 449
Cdd:COG2206   248 EEIPLLARILAVADVYDALTSDRPYRKALSPEEALEELRKGAGTQFDPELVEAFIKVLGIYP 309
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 282-425 7.10e-23

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 94.33  E-value: 7.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 282 PFTSGHSSRVAIFSTLIAEELKVDKEDRLWLKRAALLHDLGKLGVSNTIldkpgklDDDEWAKIQNHAVFTREIIEKISP 361
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELGLSEEDIELLRLAALLHDIGKPGTPDAI-------TEEESELEKDHAIVGAEILRELLL 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1789013403 362 LKQFAK-------MAAAHHEKLDGTGYPDKLVADEISMMTRIITTADIFDAITAE-RPYRGAVPIPKTLEIM 425
Cdd:cd00077    74 EEVIKLidelilaVDASHHERLDGLGYPDGLKGEEITLEARIVKLADRLDALRRDsREKRRRIAEEDLEELL 145
HDGYP COG2206
HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal ...
 12-249 3.53e-16

HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant) [Signal transduction mechanisms];


Pssm-ID: 441808 [Multi-domain]  Cd Length: 316  Bit Score: 79.25  E-value: 3.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403  12 LAELVSSLTVALDMTEGQPPEHSMRCCWIGMHIGERMNLSSSELHDLYFTLLLKDAGcssnaaricelyatddltfkqry 91
Cdd:COG2206   126 LPDALLALLAALDAKDPYTYGHSVRVAVLALALARELGLSEEELEDLGLAALLHDIG----------------------- 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403  92 KTvgtsltsainfvlknagsgehwhkRISTTIdILKNG--TDYAQELIQTRCTKGAEVARELLFSEDVAQGIQHLDEHWD 169
Cdd:COG2206   183 KI------------------------GIPDEI-LNKPGklTDEEFEIIKKHPEYGYEILKKLPGLSEVAEIVLQHHERLD 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 170 GSGRPDALMHDQIPLFSRIALLAQVMD------VFQREHDLNIAFSELENRSGNWLDPNLVAIakqlkdnpdFIKALNAP 243
Cdd:COG2206   238 GSGYPRGLKGEEIPLLARILAVADVYDaltsdrPYRKALSPEEALEELRKGAGTQFDPELVEA---------FIKVLGIY 308


                  ....*.
gi 1789013403 244 SIVPFV 249
Cdd:COG2206   309 PPVVEI 314
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 287-414 3.34e-15

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 71.94  E-value: 3.34e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403  287 HSSRVAIFSTLIAEELKvdKEDRLWLKRAALLHDLGKLGVSNTILDKPGKLDDdewakiqnHAVFTREIIEKISPLKQFA 366
Cdd:smart00471   8 HSLRVAQLAAALAEELG--LLDIELLLLAALLHDIGKPGTPDSFLVKTSVLED--------HHFIGAEILLEEEEPRILE 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1789013403  367 KMA----AAHHEKLDGTGYpdklvaDEISMMTRIITTADIFDAITAERPYRG 414
Cdd:smart00471  78 EILrtaiLSHHERPDGLRG------EPITLEARIVKVADRLDALRADRRYRR 123
HD_5 pfam13487
HD domain; HD domains are metal dependent phosphohydrolases.
 335-397 1.03e-13

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 433249 [Multi-domain]  Cd Length: 64  Bit Score: 65.70  E-value: 1.03e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1789013403 335 GKLDDDEWAKIQNHAVFTREIIEKISPL-KQFAKMAAAHHEKLDGTGYPDKLVADEISMMTRII 397
Cdd:pfam13487   1 GTLTPEEREIINRHPEHTARLLSTLPRLpKEVAEIIAQHHERLDGSGYPRGLKGEEIPLGARIL 64
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 305-380 1.46e-13

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 69.81  E-value: 1.46e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1789013403 305 DKEDRLWLKRAALLHDLGKLGVSNTILDKPGKLDDDEWAKIQNHAVFTREIIEKISPLkqfaKMAAAHHEKLDGTG 380
Cdd:COG3437   133 LDDLVLYLKLAAPLHDIGKIGIPDAILLKPGKLTPEEWEITHAHIGAEILSGSLLPLL----QLAAEIHERWDGSG 204
HD pfam01966
HD domain; HD domains are metal dependent phosphohydrolases.
 284-406 5.94e-13

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 460398 [Multi-domain]  Cd Length: 110  Bit Score: 64.95  E-value: 5.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 284 TSGHSSRVAIFSTLIAEELkvDKEDRLWLKRAALLHDLGKLGVSntildkpgkLDDDEWAKIQNHAVFTREIIEKI---S 360
Cdd:pfam01966   1 RLEHSLRVALLARELAEEL--GELDRELLLLAALLHDIGKGPFG---------DEKPEFEIFLGHAVVGAEILRELekrL 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1789013403 361 PLKQFAKMAAAHHEKLDGTGYPDKLVADEismmtRIITTADIFDAI 406
Cdd:pfam01966  70 GLEDVLKLILEHHESWEGAGYPEEISLEA-----RIVKLADRLDAL 110
HD_5 pfam13487
HD domain; HD domains are metal dependent phosphohydrolases.
 130-188 2.47e-08

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 433249 [Multi-domain]  Cd Length: 64  Bit Score: 50.29  E-value: 2.47e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 130 TDYAQELIQTRCTKGAEVAREL-LFSEDVAQGIQHLDEHWDGSGRPDALMHDQIPLFSRI 188
Cdd:pfam13487   4 TPEEREIINRHPEHTARLLSTLpRLPKEVAEIIAQHHERLDGSGYPRGLKGEEIPLGARI 63
RnaY COG1418
HD superfamily phosphodieaserase, includes HD domain of RNase Y [Translation, ribosomal ...
 287-425 1.73e-06

HD superfamily phosphodieaserase, includes HD domain of RNase Y [Translation, ribosomal structure and biogenesis, General function prediction only];


Pssm-ID: 441028 [Multi-domain]  Cd Length: 191  Bit Score: 48.36  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 287 HSSRVAIFSTLIAEELKVDKEDrlwLKRAALLHDLGKLgvsntiLDKPGKLDDDEWA-----KIQNHAVFTREIIEKIsp 361
Cdd:COG1418    22 HSLRVAKLAGLIAAEEGADVEV---AKRAALLHDIGKA------KDHEVEGSHAEIGaelarKYLESLGFPEEEIEAV-- 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1789013403 362 lkqfAKMAAAHHEklDGTGYPDKLVAdeismmtRIITTADIFDAItaerpyrGAVPIPKTLEIM 425
Cdd:COG1418    91 ----VHAIEAHSF--SGGIEPESLEA-------KIVQDADRLDAL-------GAIGVARAFAIG 134
HDOD pfam08668
HDOD domain;
287-374 2.44e-06

HDOD domain;


Pssm-ID: 430141 [Multi-domain]  Cd Length: 196  Bit Score: 47.99  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 287 HSSRVAIFSTLIAEELKVDKEDRLWLkrAALLHDLGKLGVSNTILDKPGKLDD----DEWAKIQ--------NHAVFTRE 354
Cdd:pfam08668  98 HSLACALAARLLARRLGLDDPEEAFL--AGLLHDIGKLILLSLLPDKYEELLEkaaeEGISLLEaerellgtDHAEVGAA 175

                          90       100
                  ....*....|....*....|
gi 1789013403 355 IIEKISPLKQFAKMAAAHHE 374
Cdd:pfam08668 176 LLERWNLPEELVEAIAYHHN 195
HDIG TIGR00277
HDIG domain; This domain is found in a few known nucleotidyltransferes and in a large number ...
 287-375 5.20e-06

HDIG domain; This domain is found in a few known nucleotidyltransferes and in a large number of uncharacterized proteins. It contains four widely separated His residues, the second of which is part of an invariant dipeptide His-Asp in a region matched approximately by the motif HDIG. This model may annotate homologous domains in which one or more of the His residues is conserved but misaligned, and some probable false-positive hits.


Pssm-ID: 272994 [Multi-domain]  Cd Length: 80  Bit Score: 44.25  E-value: 5.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 287 HSSRVAIFSTLIAEELKVDKEdrLWlKRAALLHDLgklgvsntildkpGKLDDDEWAKIQNHAVFTREIIEKISPLKQFA 366
Cdd:TIGR00277   8 HSLEVAKLAEALARELGLDVE--LA-RRGALLHDI-------------GKPITREGVIFESHVVVGAEIARKYGEPLEVI 71


                  ....*....
gi 1789013403 367 KMAAAHHEK 375
Cdd:TIGR00277  72 DIIAEHHGK 80
PRK12704 PRK12704
phosphodiesterase; Provisional
 287-415 3.10e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.23  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 287 HSSRVAIFSTLIAEELKVDKEdrlwL-KRAALLHDLGK-----LGVSNTILdkpGKldddEWAKIQN-HAVftreIIEKI 359
Cdd:PRK12704  339 HSIEVAHLAGLMAAELGLDVK----LaKRAGLLHDIGKaldheVEGSHVEI---GA----ELAKKYKeSPV----VINAI 403

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1789013403 360 splkqfakmaAAHHekldgtgypdklvaDEISMMTRIITTADIFDAITAERPyrGA 415
Cdd:PRK12704  404 ----------AAHH--------------GDEEPTSIEAVLVAAADAISAARP--GA 433
PRK12705 PRK12705
hypothetical protein; Provisional
 287-415 1.11e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 41.23  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 287 HSSRVAIFSTLIAEELKVDKEdrlWLKRAALLHDLgklgvsntildkpGKLDDDEWAKiqNHAVFTREIIEKISPLKQFA 366
Cdd:PRK12705  327 HSLEVAHLAGIIAAEIGLDPA---LAKRAGLLHDI-------------GKSIDRESDG--NHVEIGAELARKFNEPDEVI 388

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1789013403 367 KMAAAHHEKLDGTGYPDKLVAdeismmtriittadIFDAITAERPyrGA 415
Cdd:PRK12705  389 NAIASHHNKVNPETVYSVLVQ--------------IADALSAARP--GA 421
Cas3''_I cd09641
CRISPR/Cas system-associated protein Cas3''; CRISPR (Clustered Regularly Interspaced Short ...
 287-377 1.48e-03

CRISPR/Cas system-associated protein Cas3''; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; HD-like nuclease, specifically digesting double-stranded oligonucleotides and preferably cleaving at G:C pairs; signature gene for Type I


Pssm-ID: 193608 [Multi-domain]  Cd Length: 200  Bit Score: 39.95  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789013403 287 HSSRVAIFSTLIAEELK-----VDKEDRLWLKRAALLHDLGKLgvsNT-----ILDKPGKLDDDEWAKIqNH----AVFT 352
Cdd:cd09641    12 HLLDVAAWDAELAEEFArklglELGLSRELLALAGLLHDLGKA---TPafqkyLRGGKEALREGKRKEV-RHsllgALLL 87

                          90       100
                  ....*....|....*....|....*....
gi 1789013403 353 REIIEKISPLKQFAKMAA----AHHEKLD 377
Cdd:cd09641    88 YELLKELGLDEELALLLAyaiaGHHGGLP 116
HDOD COG1639
HD-like signal output (HDOD) domain, no enzymatic activity [Signal transduction mechanisms];
287-324 2.40e-03

HD-like signal output (HDOD) domain, no enzymatic activity [Signal transduction mechanisms];


Pssm-ID: 441246 [Multi-domain]  Cd Length: 244  Bit Score: 39.56  E-value: 2.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1789013403 287 HSSRVAIFSTLIAEELKVDKEDRLWLkrAALLHDLGKL 324
Cdd:COG1639   108 HSLAVAAAARALARRLGLLDPEEAFL--AGLLHDIGKL 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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