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Conserved domains on  [gi|1789925416|ref|WP_158342540|]
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MULTISPECIES: PH domain-containing protein [Lachnospiraceae]

Protein Classification

PH domain-containing protein( domain architecture ID 10508669)

bacterial Pleckstrin homology (bPH) domain-containing protein may be involved in protein-protein interactions

CATH:  2.30.29.50
Gene Ontology:  GO:0005515
PubMed:  15493994|22728242|19913036
SCOP:  3000134

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bPH_2 pfam03703
Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies ...
 16-93 9.76e-22

Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure.


:

Pssm-ID: 427450 [Multi-domain]  Cd Length: 78  Bit Score: 81.88  E-value: 9.76e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1789925416  16 WTFTKYMVTEDLITIDEGILKKVENDCYMYKVQDVTLNNSLLERIFGLGTVVCHTGDTTHPKLELVHIKNAREIKDYI 93
Cdd:pfam03703   1 YRATGYTITDRRVVVRSGILGRKRVDIPLERIQDVSLSQSPLQRRLGLGTIVIDTAGGSGVRLPLRDVPDAEELREWL 78
 
Name Accession Description Interval E-value
bPH_2 pfam03703
Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies ...
 16-93 9.76e-22

Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure.


Pssm-ID: 427450 [Multi-domain]  Cd Length: 78  Bit Score: 81.88  E-value: 9.76e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1789925416  16 WTFTKYMVTEDLITIDEGILKKVENDCYMYKVQDVTLNNSLLERIFGLGTVVCHTGDTTHPKLELVHIKNAREIKDYI 93
Cdd:pfam03703   1 YRATGYTITDRRVVVRSGILGRKRVDIPLERIQDVSLSQSPLQRRLGLGTIVIDTAGGSGVRLPLRDVPDAEELREWL 78
YdbT COG3428
Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain ...
 9-101 2.76e-16

Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain [Function unknown];


Pssm-ID: 442654 [Multi-domain]  Cd Length: 410  Bit Score: 73.20  E-value: 2.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789925416   9 VLFFGLPWTFTKYMVTEDLITIDEGILKKVENDCYMYKVQDVTLNNSLLERIFGLGTVVCHT--GDTTHPKLELVHIKNA 86
Cdd:COG3428    56 LLVSYLRWRTTRYRITDDRLIVRSGVLSRKRREIPLDRIQSVDVSQPLLHRLFGLGTVRIETagGGESEVELDALSVPEA 135

                          90
                  ....*....|....*
gi 1789925416  87 REIKDYILVASEQAR 101
Cdd:COG3428   136 ERLRRLLLERAAGAA 150
 
Name Accession Description Interval E-value
bPH_2 pfam03703
Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies ...
 16-93 9.76e-22

Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure.


Pssm-ID: 427450 [Multi-domain]  Cd Length: 78  Bit Score: 81.88  E-value: 9.76e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1789925416  16 WTFTKYMVTEDLITIDEGILKKVENDCYMYKVQDVTLNNSLLERIFGLGTVVCHTGDTTHPKLELVHIKNAREIKDYI 93
Cdd:pfam03703   1 YRATGYTITDRRVVVRSGILGRKRVDIPLERIQDVSLSQSPLQRRLGLGTIVIDTAGGSGVRLPLRDVPDAEELREWL 78
YdbT COG3428
Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain ...
 9-101 2.76e-16

Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain [Function unknown];


Pssm-ID: 442654 [Multi-domain]  Cd Length: 410  Bit Score: 73.20  E-value: 2.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789925416   9 VLFFGLPWTFTKYMVTEDLITIDEGILKKVENDCYMYKVQDVTLNNSLLERIFGLGTVVCHT--GDTTHPKLELVHIKNA 86
Cdd:COG3428    56 LLVSYLRWRTTRYRITDDRLIVRSGVLSRKRREIPLDRIQSVDVSQPLLHRLFGLGTVRIETagGGESEVELDALSVPEA 135

                          90
                  ....*....|....*
gi 1789925416  87 REIKDYILVASEQAR 101
Cdd:COG3428   136 ERLRRLLLERAAGAA 150
YdbS COG3402
Uncharacterized membrane protein YdbS, contains bPH2 (bacterial pleckstrin homology) domain ...
 16-94 2.74e-09

Uncharacterized membrane protein YdbS, contains bPH2 (bacterial pleckstrin homology) domain [Function unknown];


Pssm-ID: 442629 [Multi-domain]  Cd Length: 143  Bit Score: 51.36  E-value: 2.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789925416  16 WTFTKYMVTEDLITIDEGILKKVENDCYMYKVQDVTLNNSLLERIFGLGTVVCHT-GDTTHPKLELVHIKNAREIKDYIL 94
Cdd:COG3402    61 YRRWRYEVREDDLYIRRGVLFRRRTVVPYGRIQHVDTEQGPLERLFGLATVTVTTaGSSGDVTIPGLPEEEAERLRDRLA 140
YdbT COG3428
Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain ...
 7-94 3.80e-04

Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain [Function unknown];


Pssm-ID: 442654 [Multi-domain]  Cd Length: 410  Bit Score: 38.53  E-value: 3.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789925416   7 KRVLFFG-LPWTFTKYMVTEDLITIDEGILKK----VENDcymyKVQDVTLNNSLLERIFGLGTVVCHT-GDTTHPKLEL 80
Cdd:COG3428   318 RRARWLApLRYRRLGYALTGDYLVVRSGFLTRrtvvVPRD----RIQSVRLSQSPFQRRLGLATVRVDTaAGPGSYTVPD 393

                          90
                  ....*....|....
gi 1789925416  81 VHIKNAREIKDYIL 94
Cdd:COG3428   394 LDAEDARALAAWLL 407
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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