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Conserved domains on  [gi|1791039323|ref|WP_158587295|]
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MULTISPECIES: sensor histidine kinase KdpD [Blautia]

Protein Classification

sensor histidine kinase( domain architecture ID 11454343)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0007165|GO:0004673|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
103-338 1.90e-75

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


:

Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 232.10  E-value: 1.90e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 103 LEYKARAAEKEKAETQQMVSDITHQLKTPITNIKMYGETLCE-ENLSKNEERQFIQIILQQVDKLEFLIESLAEMSRLES 181
Cdd:COG2205     2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 182 KMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPT-IEVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNL 260
Cdd:COG2205    82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1791039323 261 EMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLPRRAA 338
Cdd:COG2205   162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
103-338 1.90e-75

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 232.10  E-value: 1.90e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 103 LEYKARAAEKEKAETQQMVSDITHQLKTPITNIKMYGETLCE-ENLSKNEERQFIQIILQQVDKLEFLIESLAEMSRLES 181
Cdd:COG2205     2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 182 KMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPT-IEVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNL 260
Cdd:COG2205    82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1791039323 261 EMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLPRRAA 338
Cdd:COG2205   162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 234-336 6.21e-36

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 125.84  E-value: 6.21e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  234 EALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAA-KTEGLGIGLYLARQIITL 312
Cdd:smart00387   8 QVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrKIGGTGLGLSIVKKLVEL 87

                           90       100
                   ....*....|....*....|....
gi 1791039323  313 QGGYIKVRSKEGYGTEFEVFLPRR 336
Cdd:smart00387  88 HGGEISVESEPGGGTTFTITLPLE 111
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 235-333 1.85e-35

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 124.25  E-value: 1.85e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 235 ALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQG 314
Cdd:cd00075     4 VLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVEAHG 83

                          90
                  ....*....|....*....
gi 1791039323 315 GYIKVRSKEGYGTEFEVFL 333
Cdd:cd00075    84 GRITVESEPGGGTTFTVTL 102
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 26-337 8.50e-34

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 129.58  E-value: 8.50e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  26 LQPV--SSEIKILLWvsmwGLWAAGIG-----SYLYFRNQYVkysRGVCHYAQEIMNGNPCAevqnqetltskmvMELQK 98
Cdd:PRK11100  173 MAPFikRSERRILWA----GALLLGIAlligaGVVWWLNRSI---RRLTRYADAVTEGKPVP-------------LPKLG 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  99 TGEILEYkARAAEK-----E-KAETQQMVSDITHQLKTPITNIKMYGETLcEENLSKNEERQFIQIILQQVDKLEFLIES 172
Cdd:PRK11100  233 SSELREL-AQALESmrvklEgKAYVEQYVQTLTHELKSPLAAIRGAAELL-QEDPPPEDRARFTGNILTQSARLQQLIDR 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 173 LAEMSRLESKMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVrPTIEVSHDSKWTAEALGNILDNAVKYTQSGGK 252
Cdd:PRK11100  311 LLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSPEGGT 389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 253 ITVSARNLEMYVVISISDNGIGIdPGhY--NRIFQRFY---REAKAAKTEGLgiGLYLARQIITLQGGYIKVRSKEGYGT 327
Cdd:PRK11100  390 ITLSAEVDGEQVALSVEDQGPGI-PD-YalPRIFERFYslpRPANGRKSTGL--GLAFVREVARLHGGEVTLRNRPEGGV 465

                         330
                  ....*....|
gi 1791039323 328 EFEVFLPRRA 337
Cdd:PRK11100  466 LATLTLPRHF 475
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 228-336 1.54e-30

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 111.69  E-value: 1.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 228 DSKWTAEALGNILDNAVKYTQSGGKITVSARNlEMYVVISISDNGIGIDPGHYNRIFQRFYReAKAAKTEGLGIGLYLAR 307
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFST-ADKRGGGGTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*....
gi 1791039323 308 QIITLQGGYIKVRSKEGYGTEFEVFLPRR 336
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTLPLA 108
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
103-338 1.90e-75

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 232.10  E-value: 1.90e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 103 LEYKARAAEKEKAETQQMVSDITHQLKTPITNIKMYGETLCE-ENLSKNEERQFIQIILQQVDKLEFLIESLAEMSRLES 181
Cdd:COG2205     2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 182 KMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPT-IEVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNL 260
Cdd:COG2205    82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1791039323 261 EMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLPRRAA 338
Cdd:COG2205   162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
108-338 1.01e-70

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 225.20  E-value: 1.01e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 108 RAAEKEKaetQQMVSDITHQLKTPITNIKMYGETLCEENLSKNEERQ-FIQIILQQVDKLEFLIESLAEMSRLESKMLHM 186
Cdd:COG5002   159 ERLEQMR---REFVANVSHELRTPLTSIRGYLELLLDGAADDPEERReYLEIILEEAERLSRLVNDLLDLSRLESGELKL 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 187 HPENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPT-IEVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNLEMYVV 265
Cdd:COG5002   236 EKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVR 315

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1791039323 266 ISISDNGIGIDPGHYNRIFQRFYR--EAKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLPRRAA 338
Cdd:COG5002   316 ISVRDTGIGIPEEDLPRIFERFYRvdKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
92-336 1.36e-69

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 220.16  E-value: 1.36e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  92 MVMELQKTGEILEYKARAAEKEKaetQQMVSDITHQLKTPITNIKMYGETLCEEnlSKNEERQFIQIILQQVDKLEFLIE 171
Cdd:COG0642    88 LLLLLLLLLLALLLLLEEANEAK---SRFLANVSHELRTPLTAIRGYLELLLEE--LDEEQREYLETILRSADRLLRLIN 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 172 SLAEMSRLESKMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPTIE-VSHDSKWTAEALGNILDNAVKYTQSG 250
Cdd:COG0642   163 DLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPEG 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 251 GKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFE 330
Cdd:COG0642   243 GTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFT 322


                  ....*.
gi 1791039323 331 VFLPRR 336
Cdd:COG0642   323 VTLPLA 328
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 104-338 3.00e-45

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 161.11  E-value: 3.00e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 104 EYKARAAEKEKA--ETQQMVSDITHQLKTPITNIKMYGETL---CEENLSKnEERQFIQIILQQVDKLEFLIESLAEMSR 178
Cdd:COG4251   267 ELEERTAELERSneELEQFAYVASHDLREPLRKISGFSQLLeedYGDKLDE-EGREYLERIRDAAERMQALIDDLLAYSR 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 179 LESKMLHMHPENgkLIQTVSRALDTVRSRAEEKKMELQVDVRPTIEVshDSKWTAEALGNILDNAVKYTQSG--GKITVS 256
Cdd:COG4251   346 VGRQELEFEPVD--LNELLEEVLEDLEPRIEERGAEIEVGPLPTVRG--DPTLLRQVFQNLISNAIKYSRPGepPRIEIG 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 257 ARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLPRR 336
Cdd:COG4251   422 AEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501


                  ..
gi 1791039323 337 AA 338
Cdd:COG4251   502 PA 503
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 110-338 8.34e-40

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 145.10  E-value: 8.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 110 AEKEKAeTQQMVSDITHQLKTPITNIKMYGETLCEENLSKNEE-----RQFIQIILQQVDKLEFLIESLAEMSRLESkmL 184
Cdd:COG5000   195 AERLAA-WGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEdredlERALDTIIRQVDRLKRIVDEFLDFARLPE--P 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 185 HMHPENgkLIQTVSRALDTVRSRAEEKKMELQVDVRPTI-EVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNLEMY 263
Cdd:COG5000   272 QLEPVD--LNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGR 349

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1791039323 264 VVISISDNGIGIDPGHYNRIFQRFYreakAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLPRRAA 338
Cdd:COG5000   350 VRIEVSDNGPGIPEEVLERIFEPFF----TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEE 420
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 234-336 6.21e-36

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 125.84  E-value: 6.21e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  234 EALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAA-KTEGLGIGLYLARQIITL 312
Cdd:smart00387   8 QVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrKIGGTGLGLSIVKKLVEL 87

                           90       100
                   ....*....|....*....|....
gi 1791039323  313 QGGYIKVRSKEGYGTEFEVFLPRR 336
Cdd:smart00387  88 HGGEISVESEPGGGTTFTITLPLE 111
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 101-335 9.89e-36

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 132.61  E-value: 9.89e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 101 EILEYKARAAEKEKAETQ-----------QMVSDITHQLKTPITNIKMYGETL---CEENLSKNEERQFIQIILQQVDKL 166
Cdd:COG4191   115 DITELERAEEELRELQEQlvqseklaalgELAAGIAHEINNPLAAILGNAELLrrrLEDEPDPEELREALERILEGAERA 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 167 EFLIESLAEMSRLESkmLHMHPENgkLIQTVSRALDTVRSRAEEKKMELQVDVRPTIevshdskWTAEA--------LGN 238
Cdd:COG4191   195 AEIVRSLRAFSRRDE--EEREPVD--LNELIDEALELLRPRLKARGIEVELDLPPDL-------PPVLGdpgqleqvLLN 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 239 ILDNAVK--YTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFY--REAKaaktEGLGIGLYLARQIITLQG 314
Cdd:COG4191   264 LLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttKPVG----KGTGLGLSISYGIVEKHG 339

                         250       260
                  ....*....|....*....|.
gi 1791039323 315 GYIKVRSKEGYGTEFEVFLPR 335
Cdd:COG4191   340 GRIEVESEPGGGTTFTITLPL 360
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 235-333 1.85e-35

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 124.25  E-value: 1.85e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 235 ALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQG 314
Cdd:cd00075     4 VLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVEAHG 83

                          90
                  ....*....|....*....
gi 1791039323 315 GYIKVRSKEGYGTEFEVFL 333
Cdd:cd00075    84 GRITVESEPGGGTTFTVTL 102
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
92-338 2.60e-35

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 131.51  E-value: 2.60e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  92 MVMELQKTGEILEYKARAAEKEKAET-QQMVSDITHQLKTPITNIKMYGETLcEENLSKNEERQFIQIILQQVDKLEFLI 170
Cdd:COG3852   109 VLLVLRDITERKRLERELRRAEKLAAvGELAAGLAHEIRNPLTGIRGAAQLL-ERELPDDELREYTQLIIEEADRLNNLV 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 171 ESLAEMSRleSKMLHMHPENgkLIQTVSRALDTVRSRAEeKKMELQVDVRPTI-EVSHDskwtAEALG----NILDNAVK 245
Cdd:COG3852   188 DRLLSFSR--PRPPEREPVN--LHEVLERVLELLRAEAP-KNIRIVRDYDPSLpEVLGD----PDQLIqvllNLVRNAAE 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 246 YTQSGGKITVSARNLE----------MYVVISISDNGIGIDPGHYNRIFQRFYreakAAKTEGLGIGLYLARQIITLQGG 315
Cdd:COG3852   259 AMPEGGTITIRTRVERqvtlgglrprLYVRIEVIDNGPGIPEEILDRIFEPFF----TTKEKGTGLGLAIVQKIVEQHGG 334

                         250       260
                  ....*....|....*....|...
gi 1791039323 316 YIKVRSKEGYGTEFEVFLPRRAA 338
Cdd:COG3852   335 TIEVESEPGKGTTFRIYLPLEQA 357
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 26-337 8.50e-34

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 129.58  E-value: 8.50e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  26 LQPV--SSEIKILLWvsmwGLWAAGIG-----SYLYFRNQYVkysRGVCHYAQEIMNGNPCAevqnqetltskmvMELQK 98
Cdd:PRK11100  173 MAPFikRSERRILWA----GALLLGIAlligaGVVWWLNRSI---RRLTRYADAVTEGKPVP-------------LPKLG 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  99 TGEILEYkARAAEK-----E-KAETQQMVSDITHQLKTPITNIKMYGETLcEENLSKNEERQFIQIILQQVDKLEFLIES 172
Cdd:PRK11100  233 SSELREL-AQALESmrvklEgKAYVEQYVQTLTHELKSPLAAIRGAAELL-QEDPPPEDRARFTGNILTQSARLQQLIDR 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 173 LAEMSRLESKMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVrPTIEVSHDSKWTAEALGNILDNAVKYTQSGGK 252
Cdd:PRK11100  311 LLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSPEGGT 389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 253 ITVSARNLEMYVVISISDNGIGIdPGhY--NRIFQRFY---REAKAAKTEGLgiGLYLARQIITLQGGYIKVRSKEGYGT 327
Cdd:PRK11100  390 ITLSAEVDGEQVALSVEDQGPGI-PD-YalPRIFERFYslpRPANGRKSTGL--GLAFVREVARLHGGEVTLRNRPEGGV 465

                         330
                  ....*....|
gi 1791039323 328 EFEVFLPRRA 337
Cdd:PRK11100  466 LATLTLPRHF 475
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 228-336 1.54e-30

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 111.69  E-value: 1.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 228 DSKWTAEALGNILDNAVKYTQSGGKITVSARNlEMYVVISISDNGIGIDPGHYNRIFQRFYReAKAAKTEGLGIGLYLAR 307
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFST-ADKRGGGGTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*....
gi 1791039323 308 QIITLQGGYIKVRSKEGYGTEFEVFLPRR 336
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTLPLA 108
PRK15347 PRK15347
two component system sensor kinase;
97-334 1.93e-26

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 110.12  E-value: 1.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  97 QKTGEILEYKaRAAEKEKAETQQMVSDITHQLKTPITNIKMYGETLCEENLSkNEERQFIQIILQQVDKLEFLIESLAEM 176
Cdd:PRK15347  379 ERTQALAEAK-QRAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLT-AEQMDLADTARQCTLSLLAIINNLLDF 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 177 SRLESKMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPTI--EVSHDSKWTAEALGNILDNAVKYTQSGGkIT 254
Cdd:PRK15347  457 SRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVplYLHLDSLRLRQILVNLLGNAVKFTETGG-IR 535

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 255 VSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKteGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:PRK15347  536 LRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ--GTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
120-337 1.56e-25

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 106.98  E-value: 1.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 120 MVSDITHQLKTPITNIKMYGETLcEENLSKNEERQFIQIILQQVDKLEFLIESLAEMSR-LESKMLHMHPEngKLIQTVS 198
Cdd:PRK11360  393 LVAGVAHEIRNPLTAIRGYVQIW-RQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRpRESQWQPVSLN--ALVEEVL 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 199 RALDTVRSRAEEK-KMELQVDVrPTIEVshDSKWTAEALGNILDNAVKYTQSGGKITVSARNL-EMYVVISISDNGIGID 276
Cdd:PRK11360  470 QLFQTAGVQARVDfETELDNEL-PPIWA--DPELLKQVLLNILINAVQAISARGKIRIRTWQYsDGQVAVSIEDNGCGID 546

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1791039323 277 PGHYNRIFQRFYreakAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLPRRA 337
Cdd:PRK11360  547 PELLKKIFDPFF----TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
122-337 1.73e-25

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 106.39  E-value: 1.73e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 122 SDITHQLKTPITNIKMYGETLCEENLSKNEerqfiqiiLQQVdkLEFLIESLAEMSRLESKMLHM-HPENGKLI------ 194
Cdd:PRK09835  267 ADIAHEIRTPITNLITQTEIALSQSRSQKE--------LEDV--LYSNLEELTRMAKMVSDMLFLaQADNNQLIpekkml 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 195 ---QTVSRALDTVRSRAEEKKMELQVDVRPTIeVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDN 271
Cdd:PRK09835  337 dlaDEVGKVFDFFEAWAEERGVELRFVGDPCQ-VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENP 415

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1791039323 272 GIGIDPGHYNRIFQRFYR--EAKAAKTEGLGIGLYLARQIITLQGGYIKVRSkEGYGTEFEVFLPRRA 337
Cdd:PRK09835  416 GTPIAPEHLPRLFDRFYRvdPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLPRLE 482
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
110-334 6.09e-25

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 104.48  E-value: 6.09e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 110 AEKEK-AETQQMVSDITHQLKTPITNIKMYGETLCEENLSKNEERQFIQIILQQVDKLEFLIESLAEMSRLEskmlHMHP 188
Cdd:PRK10364  229 KRKEKlVALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPT----HLAL 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 189 ENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPTIE-VSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNLEMYVVIS 267
Cdd:PRK10364  305 QAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPeIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKIS 384

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1791039323 268 ISDNGIGIDPGHYNRIFQRFYreakAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:PRK10364  385 VTDSGKGIAADQLEAIFTPYF----TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
PRK09303 PRK09303
histidine kinase;
95-334 7.39e-25

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 103.49  E-value: 7.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  95 ELQKTGEILEYKAraaEKEKAETQ-----QMVSDITHQLKTPITNIKMYGETL------CEENLSKNEERQFIQIILQQV 163
Cdd:PRK09303  127 LLQLSDELFVLRQ---ENETLLEQlkfkdRVLAMLAHDLRTPLTAASLALETLelgqidEDTELKPALIEQLQDQARRQL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 164 DKLEFLIESLAEMSRLESKMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPTI-EVSHDSKWTAEALGNILDN 242
Cdd:PRK09303  204 EEIERLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDN 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 243 AVKYTQSGGKITVSA--RNLEmYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQGGYIKVR 320
Cdd:PRK09303  284 AIKYTPEGGTITLSMlhRTTQ-KVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYGQIWVD 362

                         250
                  ....*....|....
gi 1791039323 321 SKEGYGTEFEVFLP 334
Cdd:PRK09303  363 SEPGQGSCFHFTLP 376
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 111-334 6.13e-24

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 101.97  E-value: 6.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 111 EKEKAETQQMVSD----ITHQLKTPITNIKMYGETLCEENLSknEERQFIQIILQQVDKLEFLIESLAEMSRLESkmlhM 186
Cdd:COG5809   260 LLRKSEKLSVVGElaagIAHEIRNPLTSLKGFIQLLKDTIDE--EQKTYLDIMLSELDRIESIISEFLVLAKPQA----I 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 187 HPENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPTI-EVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNLE-MYV 264
Cdd:COG5809   334 KYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIpDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDdDKV 413

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 265 VISISDNGIGIDPGHYNRIFQRFYreakAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:COG5809   414 VISVTDEGCGIPEERLKKLGEPFY----TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 206-338 9.33e-24

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 100.31  E-value: 9.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 206 SRAEEKKMELQVDVRPTIEVSHDSKWT-AEALGNILDNAVKYTQSG----GKITVSARNLEMYVVISISDNGIGIDPGHY 280
Cdd:COG3290   255 ARARERGIDLTIDIDSDLPDLPLSDTDlVTILGNLLDNAIEAVEKLpeeeRRVELSIRDDGDELVIEVEDSGPGIPEELL 334

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1791039323 281 NRIFQRFYrEAKAAktEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLPRRAA 338
Cdd:COG3290   335 EKIFERGF-STKLG--EGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-334 3.62e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 89.65  E-value: 3.62e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 228 DSKWTAEALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKT-EGLGIGLYLA 306
Cdd:cd16948     2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFqESTGMGLYLV 81

                          90       100
                  ....*....|....*....|....*...
gi 1791039323 307 RQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16948    82 KKLCDKLGHKIDVESEVGEGTTFTITFP 109
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
122-336 8.49e-22

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 95.46  E-value: 8.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 122 SDITHQLKTPITNIKMYGETLCEENLSKNEERQFIQIILQQVDKLEFLIESLAEMSRLESKMLHMHPEngklIQTVSRAL 201
Cdd:PRK11006  209 ANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNE----KVDVPMML 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 202 DTVRSRAE---EKKMELQVDVRPTIEVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPG 278
Cdd:PRK11006  285 RVLEREAQtlsQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPE 364

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 279 HYNRIFQRFYR--EAKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLPRR 336
Cdd:PRK11006  365 HIPRLTERFYRvdKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPER 424
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-334 8.57e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 88.54  E-value: 8.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 234 EALGNILDNAVKYTQSG--GKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIIT 311
Cdd:cd16921     3 QVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKIIE 82

                          90       100
                  ....*....|....*....|...
gi 1791039323 312 LQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16921    83 RHGGRIWLESEPGEGTTFYFTLP 105
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-333 3.62e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 87.08  E-value: 3.62e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 222 TIEVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNlEMYVVISISDNGIGIDPGHYNRIFQRFYREAKaAKTEGLGI 301
Cdd:cd16940     4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSA-DDGAVIRVEDNGPGIDEEELEALFERFYRSDG-QNYGGSGL 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1791039323 302 GLYLARQIITLQGGYIKVRSKEGYGTEFEVFL 333
Cdd:cd16940    82 GLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 236-334 7.69e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 86.01  E-value: 7.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 236 LGNILDNAVKYTQSGG-KITVSARNLEMYVV---ISISDNGIGIDPGHYNRIFQRFYREAKAA--KTEGLGIGLYLARQI 309
Cdd:cd16922     5 LLNLLGNAIKFTEEGEvTLRVSLEEEEEDGVqlrFSVEDTGIGIPEEQQARLFEPFSQADSSTtrKYGGTGLGLAISKKL 84

                          90       100
                  ....*....|....*....|....*
gi 1791039323 310 ITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16922    85 VELMGGDISVESEPGQGSTFTFTLP 109
PRK10490 PRK10490
sensor protein KdpD; Provisional
 107-334 5.46e-20

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 90.87  E-value: 5.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 107 ARAAEKEK--AETQQ----MVSDITHQLKTPITniKMYGE----TLceeNLSKNEERQFIQI--ILQQVDKLEFLIESLA 174
Cdd:PRK10490  648 TASEEQARlaSEREQlrnaLLAALSHDLRTPLT--VLFGQaeilTL---DLASEGSPHARQAseIRQQVLNTTRLVNNLL 722

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 175 EMSRLESKMLHMHPENGKLIQTVSRALDTVRSRAeeKKMELQVDVRPTIEVSH-DSKWTAEALGNILDNAVKYTQSGGKI 253
Cdd:PRK10490  723 DMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGL--SGHPINLSLPEPLTLIHvDGPLFERVLINLLENAVKYAGAQAEI 800

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 254 TVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFL 333
Cdd:PRK10490  801 GIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTL 880


                  .
gi 1791039323 334 P 334
Cdd:PRK10490  881 P 881
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
118-318 5.92e-19

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 87.29  E-value: 5.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 118 QQMVSDITHQLKTPITNIKMYGETLceenLSKNEERQFIQIILQQVDKLEFLIESLAEMSRLESKmLHMHPENGKLIQTV 197
Cdd:PRK09470  244 QRLLSDISHELRTPLTRLQLATALL----RRRQGESKELERIETEAQRLDSMINDLLVLSRNQQK-NHLERETFKANSLW 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 198 SRALDTVRSRAEEKKMELQVDVRP-TIEVSHDSKWTAEALGNILDNAVKYTQSggKITVSARNLEMYVVISISDNGIGID 276
Cdd:PRK09470  319 SEVLEDAKFEAEQMGKSLTVSAPPgPWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVP 396

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1791039323 277 PGHYNRIFQRFYR--EAKAAKTEGLGIGLYLARQIITLQGGYIK 318
Cdd:PRK09470  397 EEEREQIFRPFYRvdEARDRESGGTGLGLAIVENAIQQHRGWVK 440
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 238-335 1.26e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 79.77  E-value: 1.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 238 NILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAktEGLGIGLYLARQIITLQGGYI 317
Cdd:cd16943    10 NLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVG--EGTGLGLSLSYRIIQKHGGTI 87

                          90
                  ....*....|....*...
gi 1791039323 318 KVRSKEGYGTEFEVFLPR 335
Cdd:cd16943    88 RVASVPGGGTRFTIILPI 105
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-334 1.58e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 79.68  E-value: 1.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 233 AEALGNILDNAVKYtqSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYR--EAKAAKTEGLGIGLYLARQII 310
Cdd:cd16949     2 ARALENVLRNALRY--SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRvdSARDRESGGTGLGLAIAERAI 79

                          90       100
                  ....*....|....*....|....
gi 1791039323 311 TLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16949    80 EQHGGKIKASNRKPGGLRVRIWLP 103
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 236-334 2.09e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 79.25  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 236 LGNILDNAVKYT----QSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYrEAKAAKteGLGIGLYLARQIIT 311
Cdd:cd16915     5 VGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV-STKGQG--ERGIGLALVRQSVE 81

                          90       100
                  ....*....|....*....|...
gi 1791039323 312 LQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16915    82 RLGGSITVESEPGGGTTFSIRIP 104
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 119-334 2.12e-18

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 85.94  E-value: 2.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 119 QMVSDITHQLKTPITNIKMYGETLceeNLSKNEERQFIQIILQQVDKLEFLIESLAEMSRleSKMLHMHPEN-GKLIQTV 197
Cdd:COG5805   289 QLAAGIAHEIRNPLTSIKGFLQLL---QPGIEDKEEYFDIMLSELDRIESIISEFLALAK--PQAVNKEKENiNELIQDV 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 198 SrALDTVRSRAEEKKMELQVDvRPTIEVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDP 277
Cdd:COG5805   364 V-TLLETEAILHNIQIRLELL-DEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPE 441

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1791039323 278 GHYNRIFQRFYreakAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:COG5805   442 ERLKKLGEPFF----TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 235-334 8.41e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 77.49  E-value: 8.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 235 ALGNILDNAVKYtqSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQG 314
Cdd:cd16950     4 VLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISDAHG 81

                          90       100
                  ....*....|....*....|
gi 1791039323 315 GYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16950    82 GSLTLANRAGGGLCARIELP 101
PRK10604 PRK10604
sensor protein RstB; Provisional
 115-334 6.11e-17

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 81.19  E-value: 6.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 115 AETQQMVSDITHQLKTPITNIKMYGETLceENLSKNEErqfiQIILQQVDKLEFLIESLAEMSRLESKMLHMHPENGKLI 194
Cdd:PRK10604  210 ASKKQLIDGIAHELRTPLVRLRYRLEMS--DNLSAAES----QALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLP 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 195 QTVSRALDTVRSRAEEKKMELQVDVRPTIEVShDSKWTAEALGNILDNAVKYtqSGGKITVSARNLEMYVVISISDNGIG 274
Cdd:PRK10604  284 AWLSTHLADIQAVTPEKTVRLDTPHQGDYGAL-DMRLMERVLDNLLNNALRY--AHSRVRVSLLLDGNQACLIVEDDGPG 360

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1791039323 275 IDPGHYNRIFQRFYR--EAKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:PRK10604  361 IPPEERERVFEPFVRldPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 206-334 1.16e-16

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 80.73  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 206 SRAEEKKMELQVDVRPTIEVSHDSKWTAE---ALGNILDNAVKYT--QSGGKITVSARNLEMYVVISISDNGIGIDPGHY 280
Cdd:PRK11086  405 SRARELGITLIISEDSQLPDSGDEDQVHElitILGNLIENALEAVggEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEI 484

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1791039323 281 NRIFQRFYreakAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:PRK11086  485 DAIFDKGY----STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 235-336 1.91e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 74.16  E-value: 1.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 235 ALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYR--EAKAAKTEGLGIGLYLARQIITL 312
Cdd:cd16952     4 AFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRvdIERCRNTGGTGLGLAIVKHVMSR 83

                          90       100
                  ....*....|....*....|....
gi 1791039323 313 QGGYIKVRSKEGYGTEFEVFLPRR 336
Cdd:cd16952    84 HDARLLIASELGKGSRFTCLFPSS 107
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
103-334 3.69e-16

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 79.78  E-value: 3.69e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  103 LEYKARAAEKEKAETQQMVSDITHQLKTPITNIKMYGETLCEENLSKNEERQFIQIILQQVDKLEFLIESLAEMSRLESK 182
Cdd:PRK09959   698 LEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESG 777

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  183 MLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVR--PTIEVSHDSKWTAEALGNILDNAVKYTQSGG-KITVSARN 259
Cdd:PRK09959   778 NYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTfpDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGH 857

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1791039323  260 LE---MYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:PRK09959   858 IDdnhAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
238-337 2.44e-15

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 77.03  E-value: 2.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 238 NILDNAVKYTQSGGKITVSARNLEM---------------YVVISISDNGIGIDPGHYNRIFQRFYreakAAKTEGLGIG 302
Cdd:PRK13837  567 NLCSNAAQAMDGAGRVDISLSRAKLrapkvlshgvlppgrYVLLRVSDTGAGIDEAVLPHIFEPFF----TTRAGGTGLG 642

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1791039323 303 LYLARQIITLQGGYIKVRSKEGYGTEFEVFLPRRA 337
Cdd:PRK13837  643 LATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSS 677
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 95-338 2.97e-15

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 76.87  E-value: 2.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  95 ELQKTgeILEYKARAAEKEKAETQQ--MVSDITHQLKTPITNIKMYGETLCEENLSkNEERQFIQIILQQVDKLEFLIES 172
Cdd:PRK11466  422 ELQEL--VIEHRQARAEAEKASQAKsaFLAAMSHEIRTPLYGILGTAQLLADNPAL-NAQRDDLRAITDSGESLLTILND 498

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 173 LAEMSRLE--SKMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQ---VDVRPTIeVSHDSKWTAEALGNILDNAVKYT 247
Cdd:PRK11466  499 ILDYSAIEagGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLAtdiADDLPTA-LMGDPRRIRQVITNLLSNALRFT 577

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 248 QSGgKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYReaKAAKTEGLGIGLYLARQIITLQGGYIKVRSKEGYGT 327
Cdd:PRK11466  578 DEG-SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQ--VSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGS 654

                         250
                  ....*....|.
gi 1791039323 328 EFEVFLPRRAA 338
Cdd:PRK11466  655 CFCLRLPLRVA 665
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 238-334 3.67e-15

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 70.60  E-value: 3.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 238 NILDNAVKYTQSGGKITVSarnLEM----YVVISISDNGIGIDPGHYNRIFQRFYR--EAKAAKTEGLGIGLYLARQIIT 311
Cdd:cd16925    11 NLLSNAFKFTPDGGRIRCI---LEKfrlnRFLLTVSDSGPGIPPNLREEIFERFRQgdGSSTRAHGGTGLGLSIVKEFVE 87

                          90       100
                  ....*....|....*....|...
gi 1791039323 312 LQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16925    88 LHGGTVTVSDAPGGGALFQVELP 110
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
158-336 7.47e-15

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 75.05  E-value: 7.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 158 IILQQVDKLEFLIESLAEMSRlesKMLhmhpENGKLIQTVSRALDTVRS-------RAEEKkMELQVDVRPTIEVSHDSK 230
Cdd:COG2972   267 AELEDPEEAEEMLEALSKLLR---YSL----SKGDELVTLEEELELIKSyleiqklRFGDR-LEVEIEIDEELLDLLIPK 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 231 WTaeaLGNILDNAVKY----TQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFyreakAAKTEGLGIGLYLA 306
Cdd:COG2972   339 LI---LQPLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-----SSKGEGRGIGLRNV 410

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1791039323 307 RQIITLQ---GGYIKVRSKEGYGTEFEVFLPRR 336
Cdd:COG2972   411 RERLKLYygeEYGLEIESEPGEGTTVTIRIPLE 443
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 232-334 1.08e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 68.95  E-value: 1.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 232 TAEALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIIT 311
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80

                          90       100
                  ....*....|....*....|...
gi 1791039323 312 LQGGYIKVRSkEGYGTEFEVFLP 334
Cdd:cd16923    81 LHGGSASAEY-DDNHDLFKVRLP 102
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 192-333 2.70e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 68.81  E-value: 2.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 192 KLIQTVSRALDTVRSRaeeKKMELQVDVRPTIEVSHDSKWTAEALGNILDNAVKYtqSGGKITVSARNLEMYVVISISDN 271
Cdd:cd16954     1 PLLDSLCSALNKVYQR---KGVSISLDISPELRFPGERNDLMELLGNLLDNACKW--CLEFVEVTARQTDGGLHLIVDDD 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1791039323 272 GIGIDPGHYNRIFQRFYREAKaaKTEGLGIGLYLARQIITLQGGYIKV-RSKEGyGTEFEVFL 333
Cdd:cd16954    76 GPGVPESQRSKIFQRGQRLDE--QRPGQGLGLAIAKEIVEQYGGELSLsDSPLG-GARFEVVF 135
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 109-334 4.34e-14

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 73.05  E-value: 4.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 109 AAEKEKAETQQMVSDITHQLKTPITNIKMYGETLCEENLSKnEERQFIQIILQQVDKLEFLIESLAEMSRLESKMLHMHP 188
Cdd:PRK11091  275 ALEKASRDKTTFISTISHELRTPLNGIVGLSRILLDTELTA-EQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQLDN 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 189 ENGKL------IQTVSRALdtvrsrAEEK----KMELQVDVRPTIEVshDSKWTAEALGNILDNAVKYTQSGG-KITVSA 257
Cdd:PRK11091  354 QPIDFtdfladLENLSGLQ------AEQKglrfDLEPLLPLPHKVIT--DGTRLRQILWNLISNAVKFTQQGGvTVRVRY 425

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 258 RNLEMyVVISISDNGIGIDPGHYNRIFQRFYrEAKAAK----TEGLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFL 333
Cdd:PRK11091  426 EEGDM-LTFEVEDSGIGIPEDELDKIFAMYY-QVKDSHggkpATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTI 503


                  .
gi 1791039323 334 P 334
Cdd:PRK11091  504 H 504
PRK10337 PRK10337
sensor protein QseC; Provisional
 115-314 5.19e-14

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 72.37  E-value: 5.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 115 AETQQMV-------SDITHQLKTPITNIKMYGETLceeNLSKNEErQFIQIILQQ----VDKLEFLIESLAEMSRLES-- 181
Cdd:PRK10337  228 ARTHAMMvrerrftSDAAHELRSPLAALKVQTEVA---QLSDDDP-QARKKALLQlhagIDRATRLVDQLLTLSRLDSld 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 182 KMLHMHPEN-GKLIQTvsrALDTVRSRAEEKKMELQVDVRptievSHDSKWTAEAL------GNILDNAVKYTQSGGKIT 254
Cdd:PRK10337  304 NLQDVAEIPlEDLLQS---AVMDIYHTAQQAGIDVRLTLN-----AHPVIRTGQPLllsllvRNLLDNAIRYSPQGSVVD 375

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1791039323 255 V--SARNLEmyvvisISDNGIGIDPGHYNRIFQRFYREAKAAKTeGLGIGLYLARQIITLQG 314
Cdd:PRK10337  376 VtlNARNFT------VRDNGPGVTPEALARIGERFYRPPGQEAT-GSGLGLSIVRRIAKLHG 430
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-324 1.09e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 66.33  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 228 DSKWTAEALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTE-GLGIGLYLA 306
Cdd:cd16945     1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQkSTGLGLAFV 80

                          90
                  ....*....|....*...
gi 1791039323 307 RQIITLQGGYIKVRSKEG 324
Cdd:cd16945    81 QEVAQLHGGRITLRNRPD 98
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-334 3.09e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 65.29  E-value: 3.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 234 EALGNILDNAVKYT-QSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFY--REAKAAKTEGLGIGLYLARQII 310
Cdd:cd16953     3 QVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYteRPANEAFGQHSGLGLSISRQII 82

                          90       100
                  ....*....|....*....|....*...
gi 1791039323 311 TLQGGYIKVRSKE----GYGTEFEVFLP 334
Cdd:cd16953    83 EAHGGISVAENHNqpgqVIGARFTVQLP 110
glnL PRK11073
nitrogen regulation protein NR(II);
94-336 4.37e-13

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 69.34  E-value: 4.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  94 MELQK--TGEILEYKARAAEKEkaetqqMVSDITHQLKTPITNIKMYGETLcEENLSKNEERQFIQIILQQVDKLEFLIE 171
Cdd:PRK11073  111 MDNQRrlSQEQLQHAQQVAARD------LVRGLAHEIKNPLGGLRGAAQLL-SKALPDPALTEYTKVIIEQADRLRNLVD 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 172 SLaemsrLESKMLHMHpengkLIQTVSRALDTVRSRAEekkMELQVDVR------PTI-EVSHDSKWTAEALGNILDNAV 244
Cdd:PRK11073  184 RL-----LGPQRPGTH-----VTESIHKVAERVVQLVS---LELPDNVRlirdydPSLpELAHDPDQIEQVLLNIVRNAL 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 245 K-YTQSGGKITVSAR-----NL--EMYVV---ISISDNGIGIdPGHYNRIFqrFY-----REAkaakteGLGIGLYLARQ 308
Cdd:PRK11073  251 QaLGPEGGTITLRTRtafqlTLhgERYRLaarIDIEDNGPGI-PPHLQDTL--FYpmvsgREG------GTGLGLSIARN 321

                         250       260
                  ....*....|....*....|....*...
gi 1791039323 309 IITLQGGYIKVRSKEGYgTEFEVFLPRR 336
Cdd:PRK11073  322 LIDQHSGKIEFTSWPGH-TEFSVYLPIR 348
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 236-317 5.09e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 64.41  E-value: 5.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 236 LGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYR--EAKAAKTEGLGIGLYLARQIITLQ 313
Cdd:cd16946     9 FVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRveSSRNRASGGSGLGLAICHNIALAH 88


                  ....
gi 1791039323 314 GGYI 317
Cdd:cd16946    89 GGTI 92
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 118-181 6.28e-13

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 63.00  E-value: 6.28e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1791039323 118 QQMVSDITHQLKTPITNIKMYGETLCEENLSkNEERQFIQIILQQVDKLEFLIESLAEMSRLES 181
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLELLRDEKLD-EEQREYLETILRSAERLLRLINDLLDLSRIEA 65
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 235-334 7.00e-13

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 64.32  E-value: 7.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 235 ALGNILDNAVKYTQSGGKITVSARNLEM---------------YVVISISDNGIGIDPGHYNRIFQRFYREAKAAKteGL 299
Cdd:cd16919     4 AILNLAVNARDAMPEGGRLTIETSNQRVdadyalnyrdlipgnYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGK--GT 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1791039323 300 GIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16919    82 GLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
envZ PRK09467
osmolarity sensor protein; Provisional
 235-334 1.12e-12

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 68.40  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 235 ALGNILDNAVKYtqSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEGLGIGLYLARQIITLQG 314
Cdd:PRK09467  335 ALANLVVNAARY--GNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHN 412

                          90       100
                  ....*....|....*....|
gi 1791039323 315 GYIKVRSKEGYGTEFEVFLP 334
Cdd:PRK09467  413 GKVELGNSEEGGLSARAWLP 432
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 118-178 2.18e-12

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 61.46  E-value: 2.18e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1791039323 118 QQMVSDITHQLKTPITNIKMYGETLCEENLSKNEERQFIQIILQQVDKLEFLIESLAEMSR 178
Cdd:cd00082     5 GEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
107-317 3.19e-12

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 66.97  E-value: 3.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 107 ARAAEKekaeTQQM----VSDITHQLKTPITNIKmyGETlceENLsKNEERQF----IQIILQQVDKLEFLIESLAEMSR 178
Cdd:PRK10549  230 ASTLEK----NEQMrrdfMADISHELRTPLAVLR--GEL---EAI-QDGVRKFtpesVASLQAEVGTLTKLVDDLHQLSL 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 179 LESKMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPTIEVSHDSKWTAEALGNILDNAVKYTQSGGKITVSAR 258
Cdd:PRK10549  300 SDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAE 379

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1791039323 259 NLEMYVVISISDNGIGIDPGHYNRIFQRFYReAKAAKTE---GLGIGLYLARQIITLQGGYI 317
Cdd:PRK10549  380 QRDKTLRLTFADSAPGVSDEQLQKLFERFYR-TEGSRNRasgGSGLGLAICLNIVEAHNGRI 440
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 118-181 4.19e-12

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 60.66  E-value: 4.19e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1791039323  118 QQMVSDITHQLKTPITNIKMYGETLCEENLSkNEERQFIQIILQQVDKLEFLIESLAEMSRLES 181
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELLLDTELS-EEQREYLETILREAERLLRLINDLLDLSRIEA 65
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 238-334 5.22e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 61.64  E-value: 5.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 238 NILDNAVK----YTQSGGKITVS-ARNLEMYVVISISDNGIGIDPGHYNRIFQRFYreakAAKTEGLGIGLYLARQIITL 312
Cdd:cd16920     7 NLVRNGIEamseGGCERRELTIRtSPADDRAVTISVKDTGPGIAEEVAGQLFDPFY----TTKSEGLGMGLSICRSIIEA 82

                          90       100
                  ....*....|....*....|..
gi 1791039323 313 QGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16920    83 HGGRLSVESPAGGGATFQFTLP 104
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-333 1.86e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 60.60  E-value: 1.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 234 EALG----NILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFY--REAKAAKTEGLGIGLYLAR 307
Cdd:cd16947    19 EALQrilkNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYtlEDSRNSAKQGNGLGLTITK 98

                          90       100
                  ....*....|....*....|....*.
gi 1791039323 308 QIITLQGGYIKVRSKEGYGTEFEVFL 333
Cdd:cd16947    99 RLAESMGGSIYVNSKPYEKTVFTVTL 124
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 235-319 7.47e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 58.63  E-value: 7.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 235 ALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTEG-LGIGLYLARQIITLQ 313
Cdd:cd16975     8 ALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIAKNLVEKH 87


                  ....*.
gi 1791039323 314 GGYIKV 319
Cdd:cd16975    88 GGSLII 93
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
119-336 1.27e-10

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 61.91  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 119 QMVSDITHQLKTPITNIKMYGETLceenlsknEERQFIQI--ILQQVDKLEFLIESLAEMSRLESKMLHMHPENGKLIQT 196
Cdd:PRK10755  139 LFTADVAHELRTPLAGIRLHLELL--------EKQHHIDVapLIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLED 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 197 VSRAL-DTVRSRAEEKKMELQV-DVRPTIEVSHDSKWTAEALGNILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIG 274
Cdd:PRK10755  211 VILPSqDELSEMLEQRQQTLLLpESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPG 290

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1791039323 275 IDPGHYNRIFQRFYREAKaaKTEGLGIGLYLARQIITLQGGYIKVRS-KEGYGTEFEVFLPRR 336
Cdd:PRK10755  291 IDESKCGELSKAFVRMDS--RYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLPKA 351
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
122-310 1.97e-10

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 61.57  E-value: 1.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 122 SDITHQLKTPITNIKmygETLCEENLSKneerqfiQIILQQVDKLefLIESLAEMSRLESKMLH---MHPENGKLIQTVS 198
Cdd:PRK10815  271 TDLTHSLKTPLAVLQ---STLRSLRSGK-------QMSVEQAEPI--MLEQISRISQQIGYYLHrasMRSEHNLLSRELH 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 199 ----------RALDTVRSRaeeKKMELQVDVRPTIEVSHDSKWTAEALGNILDNAVKYTQSggKITVSARNLEMYVVISI 268
Cdd:PRK10815  339 svaplldnltSALNKVYQR---KGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHLHIVV 413

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1791039323 269 SDNGIGIDPGHYNRIFQRFYReakaAKT--EGLGIGLYLARQII 310
Cdd:PRK10815  414 EDDGPGIPESKRELIFDRGQR----ADTlrPGQGLGLSVAREIT 453
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-334 2.74e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 57.03  E-value: 2.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 234 EALGNILDNAVK-YTQSGGKITVSAR----------NLEMYVVISISDNGIGIDPGHYNRIFQRFYreakAAKTEGLGIG 302
Cdd:cd16918     3 QVFLNLVRNAAQaLAGSGGEIILRTRtqrqvtlghpRHRLALRVSVIDNGPGIPPDLQDTIFYPMV----SGRENGTGLG 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1791039323 303 LYLARQIITLQGGYIKVRSKEGYgTEFEVFLP 334
Cdd:cd16918    79 LAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
PRK13557 PRK13557
histidine kinase; Provisional
 233-334 3.34e-10

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 60.84  E-value: 3.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 233 AE-ALGNILDNAVKYTQSGGKITVSARNLEM---------------YVVISISDNGIGIDPGHYNRIFQRFYreakAAKT 296
Cdd:PRK13557  278 AEvALLNVLINARDAMPEGGRVTIRTRNVEIededlamyhglppgrYVSIAVTDTGSGMPPEILARVMDPFF----TTKE 353

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1791039323 297 EGLGIGLYL------ARQiitlQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:PRK13557  354 EGKGTGLGLsmvygfAKQ----SGGAVRIYSEVGEGTTVRLYFP 393
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
236-334 9.51e-10

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 59.99  E-value: 9.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 236 LGNILDNAVKYTQSGGkITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYR--EAKAAKTEGLGIGLYLARQIITLQ 313
Cdd:PRK10841  567 ISNLLSNAIKFTDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQvgTGVQRNFQGTGLGLAICEKLINMM 645

                          90       100
                  ....*....|....*....|.
gi 1791039323 314 GGYIKVRSKEGYGTEFEVFLP 334
Cdd:PRK10841  646 DGDISVDSEPGMGSQFTIRIP 666
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
123-338 1.32e-09

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 57.71  E-value: 1.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 123 DITHQLktpiTNIKMYGETLCEENLSKNEE-RQFIQIILQQVDklefliESLAEMSRLESKMLHMHPENGKLIQTVSRAL 201
Cdd:COG4585    64 GVGQSL----SAIKLQLEAARRLLDADPEAaREELEEIRELAR------EALAELRRLVRGLRPPALDDLGLAAALEELA 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 202 DTVRSRAEekkmeLQVDVRPTIEVSHDSKWTAEALGNI----LDNAVKYTQsGGKITVSARNLEMYVVISISDNGIGIDP 277
Cdd:COG4585   134 ERLLRAAG-----IRVELDVDGDPDRLPPEVELALYRIvqeaLTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDP 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1791039323 278 GhynrifqrfyreakAAKTEGLGI-GLylaRQIITLQGGYIKVRSKEGYGTEFEVFLPRRAA 338
Cdd:COG4585   208 E--------------AAPGGGLGLrGM---RERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 238-333 1.96e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 54.39  E-value: 1.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 238 NILDNAVK--YTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKteGLGIGLYLARQIITLQGG 315
Cdd:cd16976     7 NLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGK--GTGLGLSISYGIVEEHGG 84

                          90
                  ....*....|....*...
gi 1791039323 316 YIKVRSKEGYGTEFEVFL 333
Cdd:cd16976    85 RLSVANEEGAGARFTFDL 102
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-335 2.87e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 53.97  E-value: 2.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 233 AEALGNILDNAVKYTQSggKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYR--EAKAAKTEGLGIGLYLARQII 310
Cdd:cd16939     2 ARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRldPSRDRATGGFGLGLAIVHRVA 79

                          90       100
                  ....*....|....*....|....*
gi 1791039323 311 TLQGGYIKVRSKEGYGTEFEVFLPR 335
Cdd:cd16939    80 LWHGGHVECDDSELGGACFRLTWPR 104
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 208-329 7.91e-09

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 57.17  E-value: 7.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 208 AEEKKMELQVDVRPTI--EVSHDSKWTAEALGNILDNAVKYTQSGG-KITVSARNLE---MYVVISISDNGIGIDPGHYN 281
Cdd:PRK11107  383 AHEKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFTESGNiDILVELRALSntkVQLEVQIRDTGIGISERQQS 462

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1791039323 282 RIFQRFyREAKAAKTE---GLGIGLYLARQIITLQGGYIKVRSKEGYGTEF 329
Cdd:PRK11107  463 QLFQAF-RQADASISRrhgGTGLGLVITQKLVNEMGGDISFHSQPNRGSTF 512
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 228-335 1.12e-08

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 56.38  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 228 DSKWTAEALGNILDNAVK---YTQSGGKItvsarnLEMY-------VVISISDNGIGIDPGHYNRIFQRFYrEAKAAKTE 297
Cdd:PRK15053  429 DSTEFAAIVGNLLDNAFEaslRSDEGNKI------VELFlsdegddVVIEVADQGCGVPESLRDKIFEQGV-STRADEPG 501

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1791039323 298 GLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLPR 335
Cdd:PRK15053  502 EHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPK 539
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 197-338 6.51e-07

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 50.67  E-value: 6.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 197 VSRALDTVRSRAEEKKMELQVDVrPTIEVSHDskwTAEALGNIL----DNAVKY---TQSGGKITVSARNLEMYVVISIS 269
Cdd:COG3920   365 LRELLEPLRDSYGGRGIRIELDG-PDVELPAD---AAVPLGLILnelvTNALKHaflSGEGGRIRVSWRREDGRLRLTVS 440

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1791039323 270 DNGIGIDPGhynrifqrfyreAKAAKTEGLGIGL--YLARQIitlqGGYIKVRSKEgyGTEFEVFLPRRAA 338
Cdd:COG3920   441 DNGVGLPED------------VDPPARKGLGLRLirALVRQL----GGTLELDRPE--GTRVRITFPLAEL 493
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 238-334 1.88e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 45.91  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 238 NILDNAVKYTQSGGKITVSARN-LEMYVVISISDNGIGIDPGHYNRIFQRFYREAKaakteglgIGLYLARQIITLQGGY 316
Cdd:cd16955    12 NAIVHGIQEKKGKGVVKISVKKqLKNRLHIAVEDNGIGISPKVIERVEQDEMPGNK--------IGLLNVHQRLKLGYGE 83

                          90
                  ....*....|....*....
gi 1791039323 317 -IKVRSKEGYGTEFEVFLP 334
Cdd:cd16955    84 gLHIRSRPDPGTLIAFYIP 102
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 239-334 2.02e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 45.90  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 239 ILDNAVKY----TQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRifqrfyREAKAakTEGLGIGLYLARQIITL-- 312
Cdd:cd16924     9 LVENAIQHglspLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNI------LGKKP--KEGNGIGLYNVHQRLILlf 80

                          90       100
                  ....*....|....*....|...
gi 1791039323 313 -QGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16924    81 gEDYGIHIASEPDKGTRITFTIP 103
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-334 2.42e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 45.61  E-value: 2.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 228 DSKWTAEALGNILDNAVKYTQSG------GKITVSArNLEMYVVISISDNGIGIDPGHYNRIFQRFYreakAAKTEGLGI 301
Cdd:cd16944     1 DTTQISQVLTNILKNAAEAIEGRpsdvgeVRIRVEA-DQDGRIVLIVCDNGKGFPREMRHRATEPYV----TTRPKGTGL 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1791039323 302 GLYLARQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16944    76 GLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 35-321 2.73e-06

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 48.91  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  35 ILLWVSMWGLWAAGIGSYLYFRNQYVKYSRGVCHYAQEIMNGNPCAEVQ---NQETltSKMVMELQKTGEILEYKAR--- 108
Cdd:COG4192   327 LLLAIALLSLLLAVLINYFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPvdgNDEI--GRIARLLRVFRDQAIEKTQele 404

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 109 -------AAEKEKAETQ-------------QMVSDITHQLKTPITNIKMYGETLCEENLSKNEE--RQFIQIILQQVDKL 166
Cdd:COG4192   405 teieerkRIEKNLRQTQdeliqaakmavvgQTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAqlPTSLDKIEGLIERM 484

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 167 EFLIESLAEMSRLESKMLHMHPengkLIQTVSRALDTVRSRAeeKKMELQVDVRPTIEVSHDSKWTAEALGNILDNAVKY 246
Cdd:COG4192   485 DKIIKSLRQFSRKSDTPLQPVD----LRQVIEQAWELVESRA--KPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDA 558

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1791039323 247 TQSGGKITVSARNLEMYVVISISDNGIGIDPghYNRIFQRFYreakAAKTEGLGIGLYLARQIITLQGGYIKVRS 321
Cdd:COG4192   559 VATQPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFT----TTKEVGLGLGLSICRSIMQQFGGDLYLAS 627
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
197-309 2.73e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 46.06  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 197 VSRALDTVRSRAEEkkMELQVDVRPTIEVShdskwTAEALGNildnAVKYT---QSGGKITVSARNLEMYVVISISDNGI 273
Cdd:COG2172    11 LGLARRAVRALLRE--LGLDEDDADDLVLA-----VSEAVTN----AVRHAyggDPDGPVEVELELDPDGLEIEVRDEGP 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1791039323 274 GIDPGHynrifqrfYREAKAAKTEGlGIGLYLARQI 309
Cdd:COG2172    80 GFDPED--------LPDPYSTLAEG-GRGLFLIRRL 106
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
 83-334 4.74e-06

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 48.39  E-value: 4.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323  83 QNQETLTSKmvmELQKTGeiLEYkaraaEKEKAETQQMVSDITHQLKTPITNIKMYGETLCEENLSKNEERQfIQIILQQ 162
Cdd:PRK10618  426 QDREVLVNK---KLQQAQ--REY-----EKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPE-LDQLAEQ 494

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 163 VDKLEFLIESLAEMSRLESKMLHMHPENGKLIQTVSRALDTVRSRAEEKKMELQVDVRPtievSHDSKWT--AEALGNIL 240
Cdd:PRK10618  495 SDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDLIDEVLPEVLPAIKRKGLQLLIHNHL----KAEQLRIgdRDALRKIL 570

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 241 DNAVKY---TQSGGKITVSARNLEMY---VVISISDNGIGIDPGHYNRIFQRFYREAKAAK-TEGLGIGLYLARQIITLQ 313
Cdd:PRK10618  571 LLLLNYaitTTAYGKITLEVDQDESSpdrLTIRILDTGAGVSIKELDNLHFPFLNQTQGDRyGKASGLTFFLCNQLCRKL 650

                         250       260
                  ....*....|....*....|.
gi 1791039323 314 GGYIKVRSKEGYGTEFEVFLP 334
Cdd:PRK10618  651 GGHLTIKSREGLGTRYSIHLK 671
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 240-334 1.34e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 42.93  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 240 LDNAVKYTQsGGKITVSARNLEMYVVISISDNGIGIDPGhynrifqrfyreakaAKTEGLGIGLYLARQIITLQGGYIKV 319
Cdd:cd16917     9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGP---------------APPGGGGFGLLGMRERAELLGGTLTI 72

                          90
                  ....*....|....*
gi 1791039323 320 RSKEGYGTEFEVFLP 334
Cdd:cd16917    73 GSRPGGGTRVTARLP 87
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 236-334 6.03e-05

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 43.10  E-value: 6.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 236 LGNILDNAVKYTQSGGK--------ITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKAAKTE---------- 297
Cdd:cd16929    48 LFELLKNAMRATVESHGddsddlppIKVTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSLDdfsdlisgtq 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1791039323 298 -----GLGIGLYLARQIITLQGGYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16929   128 psplaGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 239-334 2.17e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 40.11  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 239 ILDNAVKYTQSG----GKITVSARNLEMYVVISISDNGIGIDPGhynrifqrfyREAKAAKTEGLGIGLYLARQIITLQG 314
Cdd:cd16956     9 IVENAVKHGLSGlldgGRVEITARLDGQHLLLEVEDNGGGMDPD----------TLARILIRSSNGLGLNLVDKRLRQAF 78

                          90       100
                  ....*....|....*....|...
gi 1791039323 315 GY---IKVRSKEGYGTEFEVFLP 334
Cdd:cd16956    79 GNdygLDIECAPGEGTRITIRLP 101
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 238-334 8.24e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 38.56  E-value: 8.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 238 NILDNAVKYTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNRIFQRFYREAKaakteGLGIGLY-LARQIITLQG-- 314
Cdd:cd16957    12 NAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEK-----GTGTALEnLNRRLIGLFGse 86

                          90       100
                  ....*....|....*....|
gi 1791039323 315 GYIKVRSKEGYGTEFEVFLP 334
Cdd:cd16957    87 ACLHIESEVHGGTEVWFVIP 106
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
240-336 1.02e-03

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 40.73  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 240 LDNAVKYTQSGgKITVSARNLEMYVVISISDNGIGIDPGHYNRifqrfyreakaakteglGIGLYLARQIITLQGGYIKV 319
Cdd:PRK11644  419 LNNIVKHADAS-AVTLQGWQQDERLMLVIEDDGSGLPPGSGQQ-----------------GFGLRGMRERVTALGGTLTI 480

                          90
                  ....*....|....*..
gi 1791039323 320 RSKegYGTEFEVFLPRR 336
Cdd:PRK11644  481 SCT--HGTRLSVSLPQR 495
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
242-280 2.67e-03

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 39.45  E-value: 2.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1791039323 242 NAVKYTQsGGKITVSAR-NLEMYVVISISDNGIGID-----PGHY 280
Cdd:PRK10935  482 NAIKHAN-ASEIAVSCVtNPDGEHTVSIRDDGIGIGelkepEGHY 525
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-328 4.98e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 36.63  E-value: 4.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1791039323 234 EALGNILDNAVKyTQSGGKITVSARNLEMYVVISISDNGIGIDPGHYNrifqrfYREAKaakteglgIGLYLARQIITLQ 313
Cdd:cd16951    46 ELLQNALKHAFS-DREGGTITIRSVVDGDYLRITVIDDGVGLPQDEDW------PNKGS--------LGLQIVRSLVEGE 110

                          90
                  ....*....|....*
gi 1791039323 314 GGYIKVRSKEGYGTE 328
Cdd:cd16951   111 LKAFLEVQSAENGTR 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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