NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1792602880|ref|WP_158674072|]
View 

MULTISPECIES: CAP domain-containing protein [unclassified Pedobacter]

Protein Classification

CAP domain-containing protein( domain architecture ID 11457140)

CAP (CSP/antigen 5/PR1) domain-containing protein

CATH:  3.40.33.10
PubMed:  18824526
SCOP:  4001882

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 31-157 6.79e-35

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


:

Pssm-ID: 441910  Cd Length: 144  Bit Score: 118.56  E-value: 6.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792602880  31 DALLKLVNDIR-SAGCncgttkmpsvGALTWNVNLSSAALYQSKYTASIKSLVHTSANGETVGTRVSATGYNWTTVGENL 109
Cdd:COG2340    22 QEVLELVNAYRaAAGL----------PPLTWDPRLTAAARAHAQDMAENGYFSHTGPDGSSPFDRLKAAGYSYRAAGENI 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1792602880 110 ASGQTTEVQVFNEWIASESHCKNIMTASFKEMGAARTDN-----YWAQVFASK 157
Cdd:COG2340    92 AAGYSTAEEAVDGWMNSPGHRANILNPDFTEIGVGVAYGgdggvYWTQVFGRP 144
 
Name Accession Description Interval E-value
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 31-157 6.79e-35

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


Pssm-ID: 441910  Cd Length: 144  Bit Score: 118.56  E-value: 6.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792602880  31 DALLKLVNDIR-SAGCncgttkmpsvGALTWNVNLSSAALYQSKYTASIKSLVHTSANGETVGTRVSATGYNWTTVGENL 109
Cdd:COG2340    22 QEVLELVNAYRaAAGL----------PPLTWDPRLTAAARAHAQDMAENGYFSHTGPDGSSPFDRLKAAGYSYRAAGENI 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1792602880 110 ASGQTTEVQVFNEWIASESHCKNIMTASFKEMGAARTDN-----YWAQVFASK 157
Cdd:COG2340    92 AAGYSTAEEAVDGWMNSPGHRANILNPDFTEIGVGVAYGgdggvYWTQVFGRP 144
CAP_bacterial cd05379
Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 30-155 1.93e-24

Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.


Pssm-ID: 349398  Cd Length: 120  Bit Score: 91.29  E-value: 1.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792602880  30 NDALLKLVNDIRsagcncgttKMPSVGALTWNVNLSSAALYQSKYTASIKSLVHTSANGETvgTRVSATGYNWTTVGENL 109
Cdd:cd05379     1 EQEVLELINEYR---------AKAGLPPLSWDPRLEKAAQDHAEDMAANGYFSHTGPDGSS--DRAARAGYWYRGAGENI 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1792602880 110 ASGQTTEVQVFNEWIASESHCKNIMTASFKEMGAA-----RTDNYWAQVFA 155
Cdd:cd05379    70 AYGQGSAEEAVNQWINSPGHRANILDPDFTEIGVGvaynsSGGTYWTQVFG 120
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 34-154 4.59e-12

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 59.14  E-value: 4.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792602880  34 LKLVNDIRSAgcncgtTKMPsvgALTWNVNLSSAALYQSKYTASIKSLVHTSANGETVGTRVSATGYNWTTVGENLASGq 113
Cdd:pfam00188   1 LDLHNEYRAA------AGLP---PLSWDNELAAAAQDHAKYCADNGSHNHRSPYGGNIYARVVAAGYALGDAGPDSAED- 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1792602880 114 ttevqVFNEWIASE-----SHCKNIMTASFKEMGAA------RTDNYWAQVF 154
Cdd:pfam00188  71 -----AVDGWYDSPgtyncGHRTNLLWPKSTKVGCAvakcgdGGTYYFVCNY 117
 
Name Accession Description Interval E-value
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 31-157 6.79e-35

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


Pssm-ID: 441910  Cd Length: 144  Bit Score: 118.56  E-value: 6.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792602880  31 DALLKLVNDIR-SAGCncgttkmpsvGALTWNVNLSSAALYQSKYTASIKSLVHTSANGETVGTRVSATGYNWTTVGENL 109
Cdd:COG2340    22 QEVLELVNAYRaAAGL----------PPLTWDPRLTAAARAHAQDMAENGYFSHTGPDGSSPFDRLKAAGYSYRAAGENI 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1792602880 110 ASGQTTEVQVFNEWIASESHCKNIMTASFKEMGAARTDN-----YWAQVFASK 157
Cdd:COG2340    92 AAGYSTAEEAVDGWMNSPGHRANILNPDFTEIGVGVAYGgdggvYWTQVFGRP 144
CAP_bacterial cd05379
Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 30-155 1.93e-24

Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.


Pssm-ID: 349398  Cd Length: 120  Bit Score: 91.29  E-value: 1.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792602880  30 NDALLKLVNDIRsagcncgttKMPSVGALTWNVNLSSAALYQSKYTASIKSLVHTSANGETvgTRVSATGYNWTTVGENL 109
Cdd:cd05379     1 EQEVLELINEYR---------AKAGLPPLSWDPRLEKAAQDHAEDMAANGYFSHTGPDGSS--DRAARAGYWYRGAGENI 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1792602880 110 ASGQTTEVQVFNEWIASESHCKNIMTASFKEMGAA-----RTDNYWAQVFA 155
Cdd:cd05379    70 AYGQGSAEEAVNQWINSPGHRANILDPDFTEIGVGvaynsSGGTYWTQVFG 120
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 34-154 4.59e-12

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 59.14  E-value: 4.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792602880  34 LKLVNDIRSAgcncgtTKMPsvgALTWNVNLSSAALYQSKYTASIKSLVHTSANGETVGTRVSATGYNWTTVGENLASGq 113
Cdd:pfam00188   1 LDLHNEYRAA------AGLP---PLSWDNELAAAAQDHAKYCADNGSHNHRSPYGGNIYARVVAAGYALGDAGPDSAED- 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1792602880 114 ttevqVFNEWIASE-----SHCKNIMTASFKEMGAA------RTDNYWAQVF 154
Cdd:pfam00188  71 -----AVDGWYDSPgtyncGHRTNLLWPKSTKVGCAvakcgdGGTYYFVCNY 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH