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Conserved domains on  [gi|1795043513|ref|WP_158701364|]
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type VI secretion system tip protein TssI/VgrG, partial [Escherichia sp. R1]

Protein Classification

type VI secretion system Vgr family protein( domain architecture ID 1002305)

type VI secretion system Vgr family protein; type VI secretion system tip protein VgrG is a core component and effector of Type VI secretion systems (T6SSs) that are involved in the pathogenicity of several Gram-negative bacteria

CATH:  2.30.110.50
Gene Ontology:  GO:0033104|GO:0033103
PubMed:  27352036

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
VI_Rhs_Vgr super family cl37255
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs ...
1-234 3.73e-74

type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.


The actual alignment was detected with superfamily member TIGR03361:

Pssm-ID: 274542 [Multi-domain]  Cd Length: 513  Bit Score: 233.25  E-value: 3.73e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513   1 SYPFVMSVDVASDSFMQTAEMLLEKNATLTIWQGVIPLRYVTGVVAGFGMQENNGWQMRYHLRIEPPLWRCGLRQNFRIF 80
Cdd:TIGR03361  24 SRLFSFRLELVSADPDIDLEDLLGQPATLTLGRDGGGPRYFHGIVTRFEQGGTGRRLTRYRLTLVPWLWLLTLRRDSRIF 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513  81 QQQDIRTISATLLNENGVTEWTPLFYEDHPAREFCVQYGESDLAFLARLWAEEGIFFFERFAADSpeQKLTLCDDVAGLS 160
Cdd:TIGR03361 104 QNKSVPEIITEVLKEHGITDFRFRLSKSYPPREYCVQYRESDLDFVSRLLEEEGIFYYFEHTEDG--HTLVLGDDASAHA 181
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1795043513 161 QAGEF--PFNPDTSAGAETECVSMFRYEAHVRPSSVQSQDYTFKVPDWPGMYEQQGESLNGQLEQYEIFDYPGRYK 234
Cdd:TIGR03361 182 PLPGAslPYNPDSGGVADRPVISQWTYRRQVRPGQVALRDYDFKKPAASLEAQASADEQGHQAPDLEHYDYPGRFK 257
 
Name Accession Description Interval E-value
VI_Rhs_Vgr TIGR03361
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs ...
1-234 3.73e-74

type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.


Pssm-ID: 274542 [Multi-domain]  Cd Length: 513  Bit Score: 233.25  E-value: 3.73e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513   1 SYPFVMSVDVASDSFMQTAEMLLEKNATLTIWQGVIPLRYVTGVVAGFGMQENNGWQMRYHLRIEPPLWRCGLRQNFRIF 80
Cdd:TIGR03361  24 SRLFSFRLELVSADPDIDLEDLLGQPATLTLGRDGGGPRYFHGIVTRFEQGGTGRRLTRYRLTLVPWLWLLTLRRDSRIF 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513  81 QQQDIRTISATLLNENGVTEWTPLFYEDHPAREFCVQYGESDLAFLARLWAEEGIFFFERFAADSpeQKLTLCDDVAGLS 160
Cdd:TIGR03361 104 QNKSVPEIITEVLKEHGITDFRFRLSKSYPPREYCVQYRESDLDFVSRLLEEEGIFYYFEHTEDG--HTLVLGDDASAHA 181
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1795043513 161 QAGEF--PFNPDTSAGAETECVSMFRYEAHVRPSSVQSQDYTFKVPDWPGMYEQQGESLNGQLEQYEIFDYPGRYK 234
Cdd:TIGR03361 182 PLPGAslPYNPDSGGVADRPVISQWTYRRQVRPGQVALRDYDFKKPAASLEAQASADEQGHQAPDLEHYDYPGRFK 257
VgrG COG3501
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly ...
3-234 5.18e-73

Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly [Intracellular trafficking, secretion, and vesicular transport, Mobilome: prophages, transposons, General function prediction only];


Pssm-ID: 442724 [Multi-domain]  Cd Length: 743  Bit Score: 235.81  E-value: 5.18e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513   3 PFVMSVDVASDSFMQTAEMLLEKNATLTIWQGVIPLRYVTGVVAGFGMQENNGWQMRYHLRIEPPLWRCGLRQNFRIFQQ 82
Cdd:COG3501    35 PFEFELELLSEDADLDLDALLGKPATLTLRTADGPERYFHGIVTEFEQLGTDGGLARYRLTLVPWLWLLTLRRDSRIFQD 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513  83 QDIRTISATLLNENGVTEWTPLFYEDHPAREFCVQYGESDLAFLARLWAEEGIFFFerFAADSPEQKLTLCDDVAGLSQA 162
Cdd:COG3501   115 KSVPDIVEEVLAEYGLAAFEFRLSGSYPPREYCVQYRESDLDFVSRLLEEEGIYYY--FEHEEGGHTLVLADDPSAHPPL 192
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1795043513 163 --GEFPFNPDTSAGAETECVSMFRYEAHVRPSSVQSQDYTFKVPDWPgMYEQQGESLNGQLEQYEIFDYPGRYK 234
Cdd:COG3501   193 pgATLPYHPRSGADEEEDSITRWRVRRRVRPGKVTLRDYDFKKPAAD-LEASASSPRDGDEGDLEVYDYPGRYT 265
Phage_GPD pfam05954
Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D ...
3-234 1.54e-61

Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D proteins and related bacterial sequences. This family also includes Bacteriophage Mu P proteins and related sequences. This protein forms the phage central baseplate hub.


Pssm-ID: 428689  Cd Length: 302  Bit Score: 194.84  E-value: 1.54e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513   3 PFVMSVDVASDSFMQTAEMLLEKNATLTIWQGVIPLRYVTGVVAGFGMQENNGWQMRYHLRIEPPLWRCGLRQNFRIFQQ 82
Cdd:pfam05954   5 LFEFELTLLSDDPDIDLKALLGQPVTVSIELDGGGPRYFHGIVTEFEQVGSDGRLTRYRLTLVPWLWLLTLRRDSRIFQN 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513  83 QDIRTISATLLNENGVTEWTPL-FYEDHPAREFCVQYGESDLAFLARLWAEEGIFFFerFAADSPEQKLTLCDDVAGLSQ 161
Cdd:pfam05954  85 KTVPDILEAVLGEHGIAVAFRFrLTRSYPPREYCVQYRESDLAFVSRLLEEEGIFYF--FEHAEGSHTLVLADDSSALPP 162
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1795043513 162 ---AGEFPFNPDTSAGAETECVSMFRYEAHVRPSSVQSQDYTFKVPDWPGMYEQQGESLNGQlEQYEIFDYPGRYK 234
Cdd:pfam05954 163 sagGPSLPYHPPSGTEAEGDHITRFTARRRLRPGTVTLRDYDYKKPRADLSAVAAAPQGAAG-SAYEVYDYPGRYD 237
 
Name Accession Description Interval E-value
VI_Rhs_Vgr TIGR03361
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs ...
1-234 3.73e-74

type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.


Pssm-ID: 274542 [Multi-domain]  Cd Length: 513  Bit Score: 233.25  E-value: 3.73e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513   1 SYPFVMSVDVASDSFMQTAEMLLEKNATLTIWQGVIPLRYVTGVVAGFGMQENNGWQMRYHLRIEPPLWRCGLRQNFRIF 80
Cdd:TIGR03361  24 SRLFSFRLELVSADPDIDLEDLLGQPATLTLGRDGGGPRYFHGIVTRFEQGGTGRRLTRYRLTLVPWLWLLTLRRDSRIF 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513  81 QQQDIRTISATLLNENGVTEWTPLFYEDHPAREFCVQYGESDLAFLARLWAEEGIFFFERFAADSpeQKLTLCDDVAGLS 160
Cdd:TIGR03361 104 QNKSVPEIITEVLKEHGITDFRFRLSKSYPPREYCVQYRESDLDFVSRLLEEEGIFYYFEHTEDG--HTLVLGDDASAHA 181
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1795043513 161 QAGEF--PFNPDTSAGAETECVSMFRYEAHVRPSSVQSQDYTFKVPDWPGMYEQQGESLNGQLEQYEIFDYPGRYK 234
Cdd:TIGR03361 182 PLPGAslPYNPDSGGVADRPVISQWTYRRQVRPGQVALRDYDFKKPAASLEAQASADEQGHQAPDLEHYDYPGRFK 257
VgrG COG3501
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly ...
3-234 5.18e-73

Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly [Intracellular trafficking, secretion, and vesicular transport, Mobilome: prophages, transposons, General function prediction only];


Pssm-ID: 442724 [Multi-domain]  Cd Length: 743  Bit Score: 235.81  E-value: 5.18e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513   3 PFVMSVDVASDSFMQTAEMLLEKNATLTIWQGVIPLRYVTGVVAGFGMQENNGWQMRYHLRIEPPLWRCGLRQNFRIFQQ 82
Cdd:COG3501    35 PFEFELELLSEDADLDLDALLGKPATLTLRTADGPERYFHGIVTEFEQLGTDGGLARYRLTLVPWLWLLTLRRDSRIFQD 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513  83 QDIRTISATLLNENGVTEWTPLFYEDHPAREFCVQYGESDLAFLARLWAEEGIFFFerFAADSPEQKLTLCDDVAGLSQA 162
Cdd:COG3501   115 KSVPDIVEEVLAEYGLAAFEFRLSGSYPPREYCVQYRESDLDFVSRLLEEEGIYYY--FEHEEGGHTLVLADDPSAHPPL 192
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1795043513 163 --GEFPFNPDTSAGAETECVSMFRYEAHVRPSSVQSQDYTFKVPDWPgMYEQQGESLNGQLEQYEIFDYPGRYK 234
Cdd:COG3501   193 pgATLPYHPRSGADEEEDSITRWRVRRRVRPGKVTLRDYDFKKPAAD-LEASASSPRDGDEGDLEVYDYPGRYT 265
Phage_GPD pfam05954
Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D ...
3-234 1.54e-61

Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D proteins and related bacterial sequences. This family also includes Bacteriophage Mu P proteins and related sequences. This protein forms the phage central baseplate hub.


Pssm-ID: 428689  Cd Length: 302  Bit Score: 194.84  E-value: 1.54e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513   3 PFVMSVDVASDSFMQTAEMLLEKNATLTIWQGVIPLRYVTGVVAGFGMQENNGWQMRYHLRIEPPLWRCGLRQNFRIFQQ 82
Cdd:pfam05954   5 LFEFELTLLSDDPDIDLKALLGQPVTVSIELDGGGPRYFHGIVTEFEQVGSDGRLTRYRLTLVPWLWLLTLRRDSRIFQN 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513  83 QDIRTISATLLNENGVTEWTPL-FYEDHPAREFCVQYGESDLAFLARLWAEEGIFFFerFAADSPEQKLTLCDDVAGLSQ 161
Cdd:pfam05954  85 KTVPDILEAVLGEHGIAVAFRFrLTRSYPPREYCVQYRESDLAFVSRLLEEEGIFYF--FEHAEGSHTLVLADDSSALPP 162
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1795043513 162 ---AGEFPFNPDTSAGAETECVSMFRYEAHVRPSSVQSQDYTFKVPDWPGMYEQQGESLNGQlEQYEIFDYPGRYK 234
Cdd:pfam05954 163 sagGPSLPYHPPSGTEAEGDHITRFTARRRLRPGTVTLRDYDYKKPRADLSAVAAAPQGAAG-SAYEVYDYPGRYD 237
vgr_GE TIGR01646
Rhs element Vgr protein; This model represents the Vgr family of proteins, associated with ...
1-234 1.31e-34

Rhs element Vgr protein; This model represents the Vgr family of proteins, associated with some classes of Rhs elements. This model does not include a large octapeptide repeat region, VGXXXXXX, found in the Vgr of Rhs classes G and E.


Pssm-ID: 273730 [Multi-domain]  Cd Length: 483  Bit Score: 128.75  E-value: 1.31e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513   1 SYPFVMSVDVASDSFMQTAEMLLEKNATLTIWQ--GVIPLRYVTGVVAGFGMQENNGWQMRYHLRIEPPLWRCGLRQNFR 78
Cdd:TIGR01646  13 SQPFTYELILRSADADLDLAAMLGKDASLSLELpdAASTQRIFTGVIAGFSLGSTANGDARYSLVLRPWLWLLTRRRNNR 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513  79 IFQQQDIRTISATLLNENGVTEWTPLFYEDHPAREFCVQYGESDLAFLARLWAEEGIFFfeRFAADSPEQKLTLCDDVAG 158
Cdd:TIGR01646  93 IFQDTSVPDIIEEILREYGFADFRFDVAREYPQREYCVQYGETDFDFILRLLEEEGIIY--YFEHDPKKHILVAPDTSGQ 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1795043513 159 L---SQAGEFPFNPDTSAGAETECVSMFRYEAHVRPSSVQSQDYTFKVpdwPGMYEQQGESLNGQLEQ---YEIFDYPGR 232
Cdd:TIGR01646 171 PqitLGYASLPFELPGAMDAREQSIYDWTRAQQVNSASVALVDYDFKN---PTARLQAQSNISRQQAQvpdLEAYDYAGS 247

                  ..
gi 1795043513 233 YK 234
Cdd:TIGR01646 248 YL 249
gpD COG3500
Phage protein D [Mobilome: prophages, transposons];
75-138 2.80e-03

Phage protein D [Mobilome: prophages, transposons];


Pssm-ID: 442723 [Multi-domain]  Cd Length: 336  Bit Score: 37.99  E-value: 2.80e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1795043513  75 QNFRIFQQQDIRTISATLLNENGvteWTPLFYEDHPAREFCVQYGESDLAFLARLWAEEGIFFF 138
Cdd:COG3500   115 RRSRSWEDTTLSDIVRQIAGRHG---LTPKVDATSIKIEHIDQTNESDLDFLTRLAERNGAVVK 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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