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Conserved domains on  [gi|1799111541|ref|WP_160165361|]
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MULTISPECIES: hypothetical protein [Acidovorax]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nuc_hydro super family cl00226
nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in ...
 7-58 6.30e-03

nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal proteins similar to the inosine-uridine preferring nucleoside hydrolase from Crithidia fasciculata, the xanthosine-inosine-uridine-adenosine-preferring nucleoside hydrolase RihC from Salmonella enterica serovar Typhimurium, the purine-specific inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax and, pyrimidine-specific uridine-cytidine preferring nucleoside hydrolases such as URH1 from Saccharomyces cerevisiae, RihA and RihB from Escherichia coli. Nucleoside hydrolases are of interest as a target for antiprotozoan drugs as, no nucleoside hydrolase activity or genes encoding these enzymes have been detected in humans and, parasitic protozoans lack de novo purine synthesis relying on nucleoside hydrolase to scavenge purine and/or pyrimidines from the environment.


The actual alignment was detected with superfamily member PLN02717:

Pssm-ID: 469670 [Multi-domain]  Cd Length: 316  Bit Score: 32.66  E-value: 6.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1799111541   7 QCDLDGRGGTSF-VALVRWNGEATLQGPPGVEAAWGFDVEAarVVPLDPQRLT 58
Cdd:PLN02717  264 ETEGICRGLTLFdNGLKRWNGENAWTGRPPVKVAVTVDAPA--VVELVKERLM 314
 
Name Accession Description Interval E-value
PLN02717 PLN02717
uridine nucleosidase
 7-58 6.30e-03

uridine nucleosidase


Pssm-ID: 178319 [Multi-domain]  Cd Length: 316  Bit Score: 32.66  E-value: 6.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1799111541   7 QCDLDGRGGTSF-VALVRWNGEATLQGPPGVEAAWGFDVEAarVVPLDPQRLT 58
Cdd:PLN02717  264 ETEGICRGLTLFdNGLKRWNGENAWTGRPPVKVAVTVDAPA--VVELVKERLM 314
 
Name Accession Description Interval E-value
PLN02717 PLN02717
uridine nucleosidase
 7-58 6.30e-03

uridine nucleosidase


Pssm-ID: 178319 [Multi-domain]  Cd Length: 316  Bit Score: 32.66  E-value: 6.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1799111541   7 QCDLDGRGGTSF-VALVRWNGEATLQGPPGVEAAWGFDVEAarVVPLDPQRLT 58
Cdd:PLN02717  264 ETEGICRGLTLFdNGLKRWNGENAWTGRPPVKVAVTVDAPA--VVELVKERLM 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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