|
Name |
Accession |
Description |
Interval |
E-value |
| GlpR |
COG1349 |
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ... |
2-248 |
4.59e-83 |
|
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];
Pssm-ID: 440960 [Multi-domain] Cd Length: 254 Bit Score: 248.51 E-value: 4.59e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 2 QHRQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAVSHKNRDIGRSFDVRRRMNSDVKKSIA 81
Cdd:COG1349 4 EERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKRAIA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 82 ENVLEHFFAGAVIGLDASSSSWNFAQLLPD-LPCTVVTSSMHNIRALANKTSIEIIATGGVYSAKYDAFYGSLSGHLLSR 160
Cdd:COG1349 84 RAAASLIEDGDTIFLDAGTTTLALARALPDrRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 161 LNIDIAICSCTGI-ADGIVWESNEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNRSPPDSIQMLC 239
Cdd:COG1349 164 FRADKAFLGASGIdAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEAL 243
|
....*....
gi 1800580150 240 RQHQINITI 248
Cdd:COG1349 244 EEAGVEVIV 252
|
|
| DeoRC |
pfam00455 |
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ... |
73-229 |
8.44e-46 |
|
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395365 Cd Length: 160 Bit Score: 150.35 E-value: 8.44e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 73 NSDVKKSIAENVLEHFFAGAVIGLDASSSSWNFAQLLPD-LPCTVVTSSMHNIRALANKTSIEIIATGGVYSAKYDAFYG 151
Cdd:pfam00455 2 NAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDrRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1800580150 152 SLSGHLLSRLNIDIAICSCTGI-ADGIVWESNEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNR 229
Cdd:pfam00455 82 PLAEEFLRQFNVDKAFIGANGIdLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
|
|
| PRK10411 |
PRK10411 |
L-fucose operon activator; |
4-232 |
1.29e-44 |
|
L-fucose operon activator;
Pssm-ID: 236684 [Multi-domain] Cd Length: 240 Bit Score: 149.96 E-value: 1.29e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRA--VSHKNRDIGRSFDVRRRMNSDVKKSIA 81
Cdd:PRK10411 5 RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAkyIHRQNQDSGDPFHIRLKSHYAHKADIA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 82 ENVLEHFFAGAVIGLDASSSSWNFAQLLPDLPCTVVTSSMHNIRALANKTSIEIIATGGVYSAKYDAFYGSLSGHLLSRL 161
Cdd:PRK10411 85 REALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLISQLKSL 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1800580150 162 NIDIAICSCTGI-ADGIVWESNEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNRSPP 232
Cdd:PRK10411 165 EIDLFIFSCEGIdSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQV 236
|
|
| AgaR |
NF040755 |
transcriptional repressor AgaR; |
16-248 |
1.84e-20 |
|
transcriptional repressor AgaR;
Pssm-ID: 468715 [Multi-domain] Cd Length: 256 Bit Score: 86.94 E-value: 1.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 16 QEASVQ--ELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAV--SHKNRDIGRSFDVRRRMNSDVKKSIAENVLEHFFAG 91
Cdd:NF040755 17 QQGSVQveDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALinDGFIPGAEPSVEDKSRLNTAVKRLIAAAAAELIKPG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 92 AVIGLDASSSSWNFAQLLPDLPCTVV-TSSMHNIRALANKTSIEIIATGGVYSAKYDAFYGSLSGHLLSRLNIDIAIcsc 170
Cdd:NF040755 97 DRVILDSGTTTYEIARHLKQHQDVVVmTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQAEQSLQNYHFDKLF--- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 171 TGIaDGIVWES-----NEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFT-NRSPPDSIQMLcRQHQI 244
Cdd:NF040755 174 LGV-DGFDLERgitthNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITdSGIPEEYLQGL-RKLGV 251
|
....
gi 1800580150 245 NITI 248
Cdd:NF040755 252 EVIL 255
|
|
| HTH_DEOR |
smart00420 |
helix_turn_helix, Deoxyribose operon repressor; |
4-56 |
1.51e-14 |
|
helix_turn_helix, Deoxyribose operon repressor;
Pssm-ID: 197714 [Multi-domain] Cd Length: 53 Bit Score: 66.09 E-value: 1.51e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAVS 56
Cdd:smart00420 1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAVS 53
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
19-53 |
1.65e-05 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 41.66 E-value: 1.65e-05
10 20 30
....*....|....*....|....*....|....*
gi 1800580150 19 SVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGR 53
Cdd:cd07377 27 SERELAEELGVSRTTVREALRELEAEGLVERRPGR 61
|
|
| cas_HTH |
TIGR01884 |
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ... |
4-53 |
3.50e-03 |
|
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]
Pssm-ID: 273852 [Multi-domain] Cd Length: 203 Bit Score: 37.34 E-value: 3.50e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGR 53
Cdd:TIGR01884 144 EELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQKGRK 193
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GlpR |
COG1349 |
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ... |
2-248 |
4.59e-83 |
|
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];
Pssm-ID: 440960 [Multi-domain] Cd Length: 254 Bit Score: 248.51 E-value: 4.59e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 2 QHRQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAVSHKNRDIGRSFDVRRRMNSDVKKSIA 81
Cdd:COG1349 4 EERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKRAIA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 82 ENVLEHFFAGAVIGLDASSSSWNFAQLLPD-LPCTVVTSSMHNIRALANKTSIEIIATGGVYSAKYDAFYGSLSGHLLSR 160
Cdd:COG1349 84 RAAASLIEDGDTIFLDAGTTTLALARALPDrRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 161 LNIDIAICSCTGI-ADGIVWESNEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNRSPPDSIQMLC 239
Cdd:COG1349 164 FRADKAFLGASGIdAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEAL 243
|
....*....
gi 1800580150 240 RQHQINITI 248
Cdd:COG1349 244 EEAGVEVIV 252
|
|
| DeoRC |
pfam00455 |
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ... |
73-229 |
8.44e-46 |
|
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395365 Cd Length: 160 Bit Score: 150.35 E-value: 8.44e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 73 NSDVKKSIAENVLEHFFAGAVIGLDASSSSWNFAQLLPD-LPCTVVTSSMHNIRALANKTSIEIIATGGVYSAKYDAFYG 151
Cdd:pfam00455 2 NAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDrRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1800580150 152 SLSGHLLSRLNIDIAICSCTGI-ADGIVWESNEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNR 229
Cdd:pfam00455 82 PLAEEFLRQFNVDKAFIGANGIdLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
|
|
| PRK10411 |
PRK10411 |
L-fucose operon activator; |
4-232 |
1.29e-44 |
|
L-fucose operon activator;
Pssm-ID: 236684 [Multi-domain] Cd Length: 240 Bit Score: 149.96 E-value: 1.29e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRA--VSHKNRDIGRSFDVRRRMNSDVKKSIA 81
Cdd:PRK10411 5 RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAkyIHRQNQDSGDPFHIRLKSHYAHKADIA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 82 ENVLEHFFAGAVIGLDASSSSWNFAQLLPDLPCTVVTSSMHNIRALANKTSIEIIATGGVYSAKYDAFYGSLSGHLLSRL 161
Cdd:PRK10411 85 REALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLISQLKSL 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1800580150 162 NIDIAICSCTGI-ADGIVWESNEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNRSPP 232
Cdd:PRK10411 165 EIDLFIFSCEGIdSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQV 236
|
|
| srlR |
PRK10434 |
DNA-binding transcriptional repressor; |
2-248 |
1.30e-30 |
|
DNA-binding transcriptional repressor;
Pssm-ID: 182457 [Multi-domain] Cd Length: 256 Bit Score: 114.01 E-value: 1.30e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 2 QHRQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAVSHKNrDIGRSFDVRRRMNSDVKKSIA 81
Cdd:PRK10434 4 RQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKE-ESDPPIDHKTLINTHKKELIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 82 ENVLEHFFAGAVIGLDASSSSwnfAQLLPDLP----CTVVTSSMHNIRALAN-KTSIEIIATGGVYSAKYDAFYGSLSGH 156
Cdd:PRK10434 83 EAAVSLIHDGDSIILDAGSTV---LQMVPLLSrfnnITVMTNSLHIVNALSElDNEQTILMPGGTFRKKSASFHGQLAEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 157 LLSRLNIDIAICSctgiADGI-----VWESNEMNAIAKrKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNRSP 231
Cdd:PRK10434 160 AFEHFTFDKLFIG----TDGIdlnagVTTFNEVYTVSK-AMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGI 234
|
250
....*....|....*..
gi 1800580150 232 PDSIQMLCRQHQINITI 248
Cdd:PRK10434 235 DPAFRQALEEKGIEVII 251
|
|
| PRK10906 |
PRK10906 |
DeoR/GlpR family transcriptional regulator; |
3-248 |
2.40e-26 |
|
DeoR/GlpR family transcriptional regulator;
Pssm-ID: 182827 [Multi-domain] Cd Length: 252 Bit Score: 102.63 E-value: 2.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 3 HRQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAvSHKNRDIGRSFDVRRRMNSDVKKSIAE 82
Cdd:PRK10906 5 QRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGA-ALPSSSVNTPWHDRKATQTEEKERIAR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 83 NVLEHFFAGAVIGLDASSSSWNFAQ-LLPDLPCTVVTSSMHNIRALANKTSIEIIATGGVYSAKYDAFYGSLSGHLLSRL 161
Cdd:PRK10906 84 KVASQIPNGATLFIDIGTTPEAVAHaLLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDFISQF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 162 NIDIAICSCTGI-ADGIVWESNEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNRSPPDSIQMLCR 240
Cdd:PRK10906 164 RLDFGILGISGIdSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASVMQVIE 243
|
....*...
gi 1800580150 241 QHQINITI 248
Cdd:PRK10906 244 DHHVQLEL 251
|
|
| AgaR |
NF040755 |
transcriptional repressor AgaR; |
16-248 |
1.84e-20 |
|
transcriptional repressor AgaR;
Pssm-ID: 468715 [Multi-domain] Cd Length: 256 Bit Score: 86.94 E-value: 1.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 16 QEASVQ--ELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAV--SHKNRDIGRSFDVRRRMNSDVKKSIAENVLEHFFAG 91
Cdd:NF040755 17 QQGSVQveDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALinDGFIPGAEPSVEDKSRLNTAVKRLIAAAAAELIKPG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 92 AVIGLDASSSSWNFAQLLPDLPCTVV-TSSMHNIRALANKTSIEIIATGGVYSAKYDAFYGSLSGHLLSRLNIDIAIcsc 170
Cdd:NF040755 97 DRVILDSGTTTYEIARHLKQHQDVVVmTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQAEQSLQNYHFDKLF--- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 171 TGIaDGIVWES-----NEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFT-NRSPPDSIQMLcRQHQI 244
Cdd:NF040755 174 LGV-DGFDLERgitthNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITdSGIPEEYLQGL-RKLGV 251
|
....
gi 1800580150 245 NITI 248
Cdd:NF040755 252 EVIL 255
|
|
| PRK09802 |
PRK09802 |
DeoR family transcriptional regulator; |
2-233 |
7.40e-20 |
|
DeoR family transcriptional regulator;
Pssm-ID: 182086 [Multi-domain] Cd Length: 269 Bit Score: 85.68 E-value: 7.40e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 2 QHRQQLILTYIetyQEASVQ--ELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAVSHKNRDIGRSFDVRRR--MNSDVK 77
Cdd:PRK09802 17 ERREQIIQRLR---QQGSVQvnDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALICDSTTPSVEPSVEDKsaLNTAMK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 78 KSIAENVLEHFFAGAVIGLDASSSSWNFAQLLPD-LPCTVVTSSMHNIRALANKTSIEIIATGGVYSAKYDAFYGSLSGH 156
Cdd:PRK09802 94 RSVAKAAVELIQPGHRVILDSGTTTFEIARLMRKhTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQ 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1800580150 157 LLSRLNIDIAICSCTGIA-DGIVWESNEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNRSPPD 233
Cdd:PRK09802 174 SLQNYHFDMLFLGVDAIDlERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPA 251
|
|
| HTH_DEOR |
smart00420 |
helix_turn_helix, Deoxyribose operon repressor; |
4-56 |
1.51e-14 |
|
helix_turn_helix, Deoxyribose operon repressor;
Pssm-ID: 197714 [Multi-domain] Cd Length: 53 Bit Score: 66.09 E-value: 1.51e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAVS 56
Cdd:smart00420 1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAVS 53
|
|
| HTH_DeoR |
pfam08220 |
DeoR-like helix-turn-helix domain; |
4-56 |
2.86e-13 |
|
DeoR-like helix-turn-helix domain;
Pssm-ID: 285436 [Multi-domain] Cd Length: 57 Bit Score: 62.66 E-value: 2.86e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAVS 56
Cdd:pfam08220 1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVS 53
|
|
| PRK13509 |
PRK13509 |
HTH-type transcriptional regulator UlaR; |
4-238 |
2.64e-10 |
|
HTH-type transcriptional regulator UlaR;
Pssm-ID: 184100 [Multi-domain] Cd Length: 251 Bit Score: 58.86 E-value: 2.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRT-HGRAVSHKNRDIGRSFDVRRRMNSDVKKSIAE 82
Cdd:PRK13509 6 RHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVrNGAEAITQQRPRWTPMNIHQAQNHDEKVRIAK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 83 NVLEHFFAGAVIGLDASSSSWNFAQLLPDLPCTVVTSSMHNIRALANKTSIEIIATGGVYSaKYDAFYGSLSGHLLSRLN 162
Cdd:PRK13509 86 AASQLCNPGESVVINCGSTAFLLGRELCGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYN-KSQSITLSPQGSENSLYA 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1800580150 163 IDIAICSCTGI-ADGiVWESNEMNAIAKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNRS-PPDSIQML 238
Cdd:PRK13509 165 GHWMFTSGKGLtADG-LYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNaDPEVLQQL 241
|
|
| PRK10681 |
PRK10681 |
DNA-binding transcriptional repressor DeoR; Provisional |
21-246 |
1.65e-07 |
|
DNA-binding transcriptional repressor DeoR; Provisional
Pssm-ID: 182644 [Multi-domain] Cd Length: 252 Bit Score: 50.85 E-value: 1.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 21 QELATHLNVSLETIRRDLNKMAKEGLLYR----THGRAVSH------KNRDIgrsfDVRRRMNSDVKKSIAENVLEHFFA 90
Cdd:PRK10681 25 KDAAALLGVSEMTIRRDLNAHSAPVVLLGgyivLEPRSASHyllsdqKSRLV----EEKRRAAQLAATLVEPNQTLFFDC 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 91 GAVIgldasssSWNFAQLLPDLPCTVVTSSMHNIRALANKTSIEIIATGGVYSAKyDAFYGSLS-GHLLSRLNIDIAICS 169
Cdd:PRK10681 101 GTTT-------PWIIEAIDNELPFTAVCYSLNTFLALQEKPHCRAILCGGEFHAS-NAIFKPLDfQQTLDNICPDIAFYS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 170 CTGI-----ADGIVWESNEMnaiaKRKMLAASKKVYLLADHSKFERKDLIQLCDLSTIHHLFTNRSPPDSIQMLCRQHQI 244
Cdd:PRK10681 173 AAGVhvskgATCFNLEELPV----KHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCPDDEFVKYAQAQRI 248
|
..
gi 1800580150 245 NI 246
Cdd:PRK10681 249 KL 250
|
|
| COG2345 |
COG2345 |
Predicted transcriptional regulator, ArsR family [Transcription]; |
4-54 |
1.25e-05 |
|
Predicted transcriptional regulator, ArsR family [Transcription];
Pssm-ID: 441914 [Multi-domain] Cd Length: 217 Bit Score: 44.91 E-value: 1.25e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRA 54
Cdd:COG2345 14 TRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERR 64
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
19-53 |
1.65e-05 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 41.66 E-value: 1.65e-05
10 20 30
....*....|....*....|....*....|....*
gi 1800580150 19 SVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGR 53
Cdd:cd07377 27 SERELAEELGVSRTTVREALRELEAEGLVERRPGR 61
|
|
| YobV |
COG2378 |
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ... |
4-54 |
2.42e-05 |
|
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];
Pssm-ID: 441945 [Multi-domain] Cd Length: 314 Bit Score: 44.68 E-value: 2.42e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGL-LYRTHGRA 54
Cdd:COG2378 6 RLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELGVpIEAERGRG 57
|
|
| MngR |
COG2188 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
22-53 |
6.44e-05 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 42.93 E-value: 6.44e-05
10 20 30
....*....|....*....|....*....|..
gi 1800580150 22 ELATHLNVSLETIRRDLNKMAKEGLLYRTHGR 53
Cdd:COG2188 34 ELAEEFGVSRMTVRKALDELVEEGLLERRQGR 65
|
|
| MntR |
COG1321 |
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription]; |
8-97 |
2.79e-04 |
|
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
Pssm-ID: 440932 [Multi-domain] Cd Length: 135 Bit Score: 39.80 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800580150 8 ILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAVS--HKNRDIGRsfDVRRRMnsdvkksiaeNVL 85
Cdd:COG1321 15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITltEEGRELAL--RIVRRH----------RLL 82
|
90
....*....|..
gi 1800580150 86 EHFFAgAVIGLD 97
Cdd:COG1321 83 ERFLV-EVLGVD 93
|
|
| HTH_GNTR |
smart00345 |
helix_turn_helix gluconate operon transcriptional repressor; |
18-55 |
3.10e-04 |
|
helix_turn_helix gluconate operon transcriptional repressor;
Pssm-ID: 197669 [Multi-domain] Cd Length: 60 Bit Score: 37.94 E-value: 3.10e-04
10 20 30
....*....|....*....|....*....|....*...
gi 1800580150 18 ASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAV 55
Cdd:smart00345 21 PSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGT 58
|
|
| MarR |
pfam01047 |
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ... |
5-51 |
3.41e-04 |
|
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
Pssm-ID: 426012 [Multi-domain] Cd Length: 59 Bit Score: 37.91 E-value: 3.41e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1800580150 5 QQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTH 51
Cdd:pfam01047 5 QFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSR 51
|
|
| HTH_MARR |
smart00347 |
helix_turn_helix multiple antibiotic resistance protein; |
5-60 |
5.65e-04 |
|
helix_turn_helix multiple antibiotic resistance protein;
Pssm-ID: 197670 [Multi-domain] Cd Length: 101 Bit Score: 38.34 E-value: 5.65e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1800580150 5 QQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHgravSHKNR 60
Cdd:smart00347 12 QFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREP----SPEDR 63
|
|
| GntR |
pfam00392 |
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ... |
19-55 |
6.15e-04 |
|
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.
Pssm-ID: 306822 [Multi-domain] Cd Length: 64 Bit Score: 37.21 E-value: 6.15e-04
10 20 30
....*....|....*....|....*....|....*..
gi 1800580150 19 SVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGRAV 55
Cdd:pfam00392 26 SERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGT 62
|
|
| COG3177 |
COG3177 |
Fic family protein [Transcription]; |
3-53 |
1.14e-03 |
|
Fic family protein [Transcription];
Pssm-ID: 442410 [Multi-domain] Cd Length: 316 Bit Score: 39.67 E-value: 1.14e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1800580150 3 HRQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGR 53
Cdd:COG3177 261 ERQRKLLELLFENPVLTASELAELLGVSRRTARRDLKDLVELGILEKVGGG 311
|
|
| COG3355 |
COG3355 |
Predicted transcriptional regulator [Transcription]; |
12-84 |
1.98e-03 |
|
Predicted transcriptional regulator [Transcription];
Pssm-ID: 442583 [Multi-domain] Cd Length: 131 Bit Score: 37.25 E-value: 1.98e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1800580150 12 IETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRThgravSHKNRDIGRSFDVRRRMNSDVKKSIAENV 84
Cdd:COG3355 37 LENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVERE-----KRNLEGGGYPYVYYAIDPEELKEKLVDDL 104
|
|
| CasRa_I-A |
cd09655 |
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ... |
4-53 |
2.41e-03 |
|
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system
Pssm-ID: 187786 [Multi-domain] Cd Length: 198 Bit Score: 38.13 E-value: 2.41e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGR 53
Cdd:cd09655 140 EELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLVEQKGTK 189
|
|
| MarR_2 |
pfam12802 |
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ... |
1-54 |
2.77e-03 |
|
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
Pssm-ID: 432797 [Multi-domain] Cd Length: 60 Bit Score: 35.26 E-value: 2.77e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1800580150 1 MQHRqqlILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRT----HGRA 54
Cdd:pfam12802 6 AQFR---VLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREpspaDRRA 60
|
|
| cas_HTH |
TIGR01884 |
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ... |
4-53 |
3.50e-03 |
|
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]
Pssm-ID: 273852 [Multi-domain] Cd Length: 203 Bit Score: 37.34 E-value: 3.50e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1800580150 4 RQQLILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGR 53
Cdd:TIGR01884 144 EELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQKGRK 193
|
|
| HTH_CRP |
smart00419 |
helix_turn_helix, cAMP Regulatory protein; |
19-53 |
4.37e-03 |
|
helix_turn_helix, cAMP Regulatory protein;
Pssm-ID: 128696 [Multi-domain] Cd Length: 48 Bit Score: 34.34 E-value: 4.37e-03
10 20 30
....*....|....*....|....*....|....*
gi 1800580150 19 SVQELATHLNVSLETIRRDLNKMAKEGLLYRTHGR 53
Cdd:smart00419 10 TRQEIAELLGLTRETVSRTLKRLEKEGLISREGGR 44
|
|
| HTH_20 |
pfam12840 |
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ... |
8-53 |
5.53e-03 |
|
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.
Pssm-ID: 432824 [Multi-domain] Cd Length: 61 Bit Score: 34.44 E-value: 5.53e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1800580150 8 ILTYIETYQEASVQELATHLNVSLETIRRDLNKMAKEGLL-YRTHGR 53
Cdd:pfam12840 15 ILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVeVVREGR 61
|
|
| |
