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Conserved domains on  [gi|1800903432|ref|WP_160580372|]
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phage protein GemA/Gp16 family protein, partial [Glaesserella parasuis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GemA super family cl01815
Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, ...
 1-68 3.63e-18

Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, including GemA (also known as gp16) protein from Bacteriophage Mu. GemA is an early protein responsible for decreasing host DNA gyrase activity, that promotes DNA relaxation of bacterial host genome. Modulates the expression of various host genes probably controlled by supercoiling of their promoters. Host genes affected include DNA replication and cell division determinants. This family also includes the Mu-like prophage FluMu protein gp16 from Haemophilus influenzae.


The actual alignment was detected with superfamily member COG4382:

Pssm-ID: 470357  Cd Length: 150  Bit Score: 72.69  E-value: 3.63e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1800903432   1 MRNKLLQLVHIGKNQLGMDDETYRSLLSQQFYQNSAKNISYSELVKLVKILQEKGAKIRL-PKAEKLSP 68
Cdd:COG4382     4 MRKRLIAKIHIAKRQLGLDDDTYRALLQRVTGKTSSKDMTDAELEKVLAELKRKGFKPKSkKKKHGGRP 72
 
Name Accession Description Interval E-value
gp16 COG4382
Mu-like prophage protein gp16 [Mobilome: prophages, transposons];
1-68 3.63e-18

Mu-like prophage protein gp16 [Mobilome: prophages, transposons];


Pssm-ID: 443508  Cd Length: 150  Bit Score: 72.69  E-value: 3.63e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1800903432   1 MRNKLLQLVHIGKNQLGMDDETYRSLLSQQFYQNSAKNISYSELVKLVKILQEKGAKIRL-PKAEKLSP 68
Cdd:COG4382     4 MRKRLIAKIHIAKRQLGLDDDTYRALLQRVTGKTSSKDMTDAELEKVLAELKRKGFKPKSkKKKHGGRP 72
GemA pfam06252
Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, ...
 18-63 1.13e-13

Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, including GemA (also known as gp16) protein from Bacteriophage Mu. GemA is an early protein responsible for decreasing host DNA gyrase activity, that promotes DNA relaxation of bacterial host genome. Modulates the expression of various host genes probably controlled by supercoiling of their promoters. Host genes affected include DNA replication and cell division determinants. This family also includes the Mu-like prophage FluMu protein gp16 from Haemophilus influenzae.


Pssm-ID: 428851  Cd Length: 118  Bit Score: 60.39  E-value: 1.13e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1800903432  18 MDDETYRSLLSQQFYQNSAKNISYSELVKLVKILQEKGAKIRLPKA 63
Cdd:pfam06252   1 LDDDTYRAMLERITGKTSAKDLTDAELAKVLAELKALGFKPKPKKR 46
 
Name Accession Description Interval E-value
gp16 COG4382
Mu-like prophage protein gp16 [Mobilome: prophages, transposons];
1-68 3.63e-18

Mu-like prophage protein gp16 [Mobilome: prophages, transposons];


Pssm-ID: 443508  Cd Length: 150  Bit Score: 72.69  E-value: 3.63e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1800903432   1 MRNKLLQLVHIGKNQLGMDDETYRSLLSQQFYQNSAKNISYSELVKLVKILQEKGAKIRL-PKAEKLSP 68
Cdd:COG4382     4 MRKRLIAKIHIAKRQLGLDDDTYRALLQRVTGKTSSKDMTDAELEKVLAELKRKGFKPKSkKKKHGGRP 72
GemA pfam06252
Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, ...
 18-63 1.13e-13

Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, including GemA (also known as gp16) protein from Bacteriophage Mu. GemA is an early protein responsible for decreasing host DNA gyrase activity, that promotes DNA relaxation of bacterial host genome. Modulates the expression of various host genes probably controlled by supercoiling of their promoters. Host genes affected include DNA replication and cell division determinants. This family also includes the Mu-like prophage FluMu protein gp16 from Haemophilus influenzae.


Pssm-ID: 428851  Cd Length: 118  Bit Score: 60.39  E-value: 1.13e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1800903432  18 MDDETYRSLLSQQFYQNSAKNISYSELVKLVKILQEKGAKIRLPKA 63
Cdd:pfam06252   1 LDDDTYRAMLERITGKTSAKDLTDAELAKVLAELKALGFKPKPKKR 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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