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Conserved domains on  [gi|1816481804|ref|WP_163486954|]
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DUF106 domain-containing protein [Halogeometricum borinquense]

Protein Classification

DUF106 domain-containing protein( domain architecture ID 10003663)

DUF106 domain-containing protein

Gene Ontology:  GO:0016020
PubMed:  27212239|26256539

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YidC COG1422
Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope ...
 107-304 4.78e-106

Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 441032  Cd Length: 198  Bit Score: 307.21  E-value: 4.78e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816481804 107 MAGVVTVGLFFAYWWQPLQRIIGSTMNVLLGPLAELLPFYAVVMIIALATGLYSTLLQANLMNMEKMSAYQERMKDIQKR 186
Cdd:COG1422     3 LAMVGALLLMAGYSIPSIRNAIGGVLDVVLGPLLAFLPFYAVILILALLTGLYSTLIQKYLMDWEKMGKYQERMKAFQKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816481804 187 RKEAQKAGDDEALDRIQQEQMEAMGDQMGMFKEQFRPMVWIMFLTIPAFIWMYWAIGVRGSGGHivLQNIVLPLVGKVSW 266
Cdd:COG1422    83 RREAQERGDDEALKKLQEEQMEMMGDQMGMSKEQFKPMVWIMVITIPIFLWLYWFIGNGAVGHA--EAVVVFPFAGEVNL 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1816481804 267 TEGVLGPMQAWIVWYFLCSMGFTQIIRKSLDIDISPST 304
Cdd:COG1422   161 TDGVLGPFPAWIVWYFLCSLAFSQIIRKALNIGMFPTK 198
 
Name Accession Description Interval E-value
YidC COG1422
Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope ...
 107-304 4.78e-106

Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441032  Cd Length: 198  Bit Score: 307.21  E-value: 4.78e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816481804 107 MAGVVTVGLFFAYWWQPLQRIIGSTMNVLLGPLAELLPFYAVVMIIALATGLYSTLLQANLMNMEKMSAYQERMKDIQKR 186
Cdd:COG1422     3 LAMVGALLLMAGYSIPSIRNAIGGVLDVVLGPLLAFLPFYAVILILALLTGLYSTLIQKYLMDWEKMGKYQERMKAFQKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816481804 187 RKEAQKAGDDEALDRIQQEQMEAMGDQMGMFKEQFRPMVWIMFLTIPAFIWMYWAIGVRGSGGHivLQNIVLPLVGKVSW 266
Cdd:COG1422    83 RREAQERGDDEALKKLQEEQMEMMGDQMGMSKEQFKPMVWIMVITIPIFLWLYWFIGNGAVGHA--EAVVVFPFAGEVNL 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1816481804 267 TEGVLGPMQAWIVWYFLCSMGFTQIIRKSLDIDISPST 304
Cdd:COG1422   161 TDGVLGPFPAWIVWYFLCSLAFSQIIRKALNIGMFPTK 198
EMC3_TMCO1 pfam01956
Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and ...
 133-299 4.01e-52

Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and archaeal proteins. Eukaryotic members include EMC3, a subunit of the ER membrane protein complex (EMC) required for protein folding, and TMCO1, a ER calcium load-activated calcium channel. Archaeal members may function as insertases of the archaeal plasma membrane.


Pssm-ID: 396507  Cd Length: 169  Bit Score: 168.61  E-value: 4.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816481804 133 NVLLGPLAE---LLPFYAVVMIIALATGLYSTLLQANLMNMEKMSAYQERMKDIQKRRKEAQKAGDDEALDRIQQEQMEA 209
Cdd:pfam01956   1 DLLLDPLIRdwvLLPIYIVILLVGILRGLLSELLQKLLIDRKKMEKYKKRMKEFQKRARELRKNGDKLSLKKFEKRQEEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816481804 210 MGDQMGMFKEQFRPMVWIMFLTIPAFIWMYWAIgvrgsgGHIVLQNIVLPLVGKV-SWT----EGVLGPMQAWIVWYFLC 284
Cdd:pfam01956  81 MEDQKEMMMDMMKPNFAIMIPQIPIMFWINYFF------SGFVVAKLPFPLTGRFkGMLqrglDGLDVTWVSSISWYFLC 154

                         170
                  ....*....|....*
gi 1816481804 285 SMGFTQIIRKSLDID 299
Cdd:pfam01956 155 SFGLSQVIRKLLGIA 169
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 169-242 8.90e-04

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 39.28  E-value: 8.90e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1816481804 169 NMEKMSAYQERMKDIQKRRKeaqkaGDDEALdriQQEQMEamgdqmgMFKE-QFRPM--VWIMFLTIPAFIWMYWAI 242
Cdd:cd20070    25 SMKKMQELQPKIKEIQEKYK-----DDKQKL---QQEMMK-------LYKEhGVNPLggCLPLLIQMPIFIALYQVL 86
 
Name Accession Description Interval E-value
YidC COG1422
Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope ...
 107-304 4.78e-106

Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441032  Cd Length: 198  Bit Score: 307.21  E-value: 4.78e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816481804 107 MAGVVTVGLFFAYWWQPLQRIIGSTMNVLLGPLAELLPFYAVVMIIALATGLYSTLLQANLMNMEKMSAYQERMKDIQKR 186
Cdd:COG1422     3 LAMVGALLLMAGYSIPSIRNAIGGVLDVVLGPLLAFLPFYAVILILALLTGLYSTLIQKYLMDWEKMGKYQERMKAFQKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816481804 187 RKEAQKAGDDEALDRIQQEQMEAMGDQMGMFKEQFRPMVWIMFLTIPAFIWMYWAIGVRGSGGHivLQNIVLPLVGKVSW 266
Cdd:COG1422    83 RREAQERGDDEALKKLQEEQMEMMGDQMGMSKEQFKPMVWIMVITIPIFLWLYWFIGNGAVGHA--EAVVVFPFAGEVNL 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1816481804 267 TEGVLGPMQAWIVWYFLCSMGFTQIIRKSLDIDISPST 304
Cdd:COG1422   161 TDGVLGPFPAWIVWYFLCSLAFSQIIRKALNIGMFPTK 198
EMC3_TMCO1 pfam01956
Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and ...
 133-299 4.01e-52

Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and archaeal proteins. Eukaryotic members include EMC3, a subunit of the ER membrane protein complex (EMC) required for protein folding, and TMCO1, a ER calcium load-activated calcium channel. Archaeal members may function as insertases of the archaeal plasma membrane.


Pssm-ID: 396507  Cd Length: 169  Bit Score: 168.61  E-value: 4.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816481804 133 NVLLGPLAE---LLPFYAVVMIIALATGLYSTLLQANLMNMEKMSAYQERMKDIQKRRKEAQKAGDDEALDRIQQEQMEA 209
Cdd:pfam01956   1 DLLLDPLIRdwvLLPIYIVILLVGILRGLLSELLQKLLIDRKKMEKYKKRMKEFQKRARELRKNGDKLSLKKFEKRQEEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816481804 210 MGDQMGMFKEQFRPMVWIMFLTIPAFIWMYWAIgvrgsgGHIVLQNIVLPLVGKV-SWT----EGVLGPMQAWIVWYFLC 284
Cdd:pfam01956  81 MEDQKEMMMDMMKPNFAIMIPQIPIMFWINYFF------SGFVVAKLPFPLTGRFkGMLqrglDGLDVTWVSSISWYFLC 154

                         170
                  ....*....|....*
gi 1816481804 285 SMGFTQIIRKSLDID 299
Cdd:pfam01956 155 SFGLSQVIRKLLGIA 169
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 169-242 8.90e-04

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 39.28  E-value: 8.90e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1816481804 169 NMEKMSAYQERMKDIQKRRKeaqkaGDDEALdriQQEQMEamgdqmgMFKE-QFRPM--VWIMFLTIPAFIWMYWAI 242
Cdd:cd20070    25 SMKKMQELQPKIKEIQEKYK-----DDKQKL---QQEMMK-------LYKEhGVNPLggCLPLLIQMPIFIALYQVL 86
60KD_IMP pfam02096
60Kd inner membrane protein;
168-242 1.49e-03

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 38.99  E-value: 1.49e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1816481804 168 MNMEKMSAYQERMKDIQKRRKEaqkagDDEaldRIQQEQMEamgdqmgMFKE-QFRPM--VWIMFLTIPAFIWMYWAI 242
Cdd:pfam02096  25 KSMAKMQELQPEMKEIQEKYKD-----DRQ---KLQQEMMK-------LYKKeGVNPLggCLPMLIQMPIFIALYRVL 87
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
169-242 3.28e-03

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 38.18  E-value: 3.28e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1816481804 169 NMEKMSAYQERMKDIQKrrkeaqKAGDDEAldRIQQEQMEAMGdqmgmfKEQFRPM--VWIMFLTIPAFIWMYWAI 242
Cdd:COG0706    52 SMAKMQELQPELKEIQE------KYKDDPQ--KLQQEMMKLYK------EEGVNPLggCLPMLIQMPIFIALYRVL 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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