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Conserved domains on  [gi|1816520665|ref|WP_163517379|]
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zinc-dependent metalloprotease [Gelidibacter japonicus]

Protein Classification

zinc-dependent metalloprotease( domain architecture ID 12182352)

zinc-dependent metalloprotease containing DUF5118, DUF5117 and DUF4953 domains, contains the extended met-zincin motif HExxHxxGxxH/D, with the first two histidines acting as ligands of the catalytic zinc, the glutamate as the general base, a strictly conserved glycine, and a third zinc-binding histidine or aspartate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4953 pfam16313
Met-zincin; This is a family of uncharacterized proteins that carry the highly characteriztic ...
 421-727 3.04e-177

Met-zincin; This is a family of uncharacterized proteins that carry the highly characteriztic met-zincin mmotif HExxHxxGxxH, the extended zinc-binding domain of metallopeptidases.


:

Pssm-ID: 435269  Cd Length: 319  Bit Score: 512.18  E-value: 3.04e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 421 FKDEIMGRLIRFVSSHEVGHTLGLPHNMASSSAYKVDDLRDPEFTKKHGTAPSIMDYARFNYVAQPGDEGV---ALMPNI 497
Cdd:pfam16313   4 FPDELMGALLRFVSAHEVGHTLGLRHNFAASSAYPVDSLRDKSFTRKYGTTPSIMDYARFNYVAQPEDQIDlsgLYPPGI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 498 GVYDKYAIAWGYRPILDAETPEDEKKTLDSWILKHAGDPMYRFGRQQSGGVIDPSSQTEDLGDDAMKASAYGIANLKRIV 577
Cdd:pfam16313  84 GPYDKWAIEWGYRPFPDAKTPEEEKAALDKWAERSAGDPGLRFGTDQDARGADPRAQTEDLGDDAVKASEYGIKNLKRIL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 578 PNLLKWTAE-DGKDYSDLGTMYGEVLGQYNRYMGHVTANIGGVYEIYKTYDQEGDVYTHVDKAKQKEALQFLQKELFTTP 656
Cdd:pfam16313 164 PNLPEWTAEkEGEDYSDLEELYVPVLLQYRRYIGHVAKNIGGVYYNYKVRGDPGPVYTPVPKEKQKEALDFLLKQLFETP 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1816520665 657 EWLLDNDIFNKI--EFDGSLERIRSTQTRTLDNILDFGRMQRMSENETINGKDAYGLLAMMQDLRKGIFSELN 727
Cdd:pfam16313 244 EWLLDPNLLNKTrgLDFDPHDRVEALQSRVLSALLSPGRLNRLVEQEARDGDKAYTLAELLDDLRKGIFKELE 316
ZnMc_MMP_like_2 cd04276
Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase ...
 294-511 1.00e-83

Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin.


:

Pssm-ID: 239803  Cd Length: 197  Bit Score: 265.34  E-value: 1.00e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 294 GELVEPKKQIVYYIDRATPEQWRKYIKQGIEDWQVAFEAAGFKNAIIAKDPPtieedPDWSPEDARYSVVRYLASPIP-N 372
Cdd:cd04276     1 AALSEPKEPIVYYLDNTFPEKYRDAIREGVLYWNKAFEKAGFKNAIIVKVLP-----DDADPGDIRYNVIRWIHSPNGgW 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 373 ANGPHVSDPRSGEIIESDINWYHNVMTLLRNWFFVQTAAinpeaqsvrfkdeimgrLIRFVSSHEVGHTLGLPHNMASSS 452
Cdd:cd04276    76 AYGPSVVDPRTGEILKADVILYSGFLRQDQLWYEDLLAA-----------------SLRYLLAHEVGHTLGLRHNFKASS 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1816520665 453 AYKVDDLRDPEFTKKHGTAPSIMDYARFNYVAQPGDEGVALMPNIGVYDKYAIAWGYRP 511
Cdd:cd04276   139 DGSNEELEDPLGTKEKGATSSVMDYPPPNVAAQGEDQGDYYPPTIGPYDKWAIEYGYTP 197
DUF5117 pfam17148
Domain of unknown function (DUF5117); This domain may fall upstream of a met-zincin domain.
 97-284 8.02e-77

Domain of unknown function (DUF5117); This domain may fall upstream of a met-zincin domain.


:

Pssm-ID: 465363  Cd Length: 189  Bit Score: 246.75  E-value: 8.02e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665  97 GGKQDEQVLRWQKKG--KRVLLRMVSHNVVANDT-LPVHEAVVNSNFEPVLFSFPIKAFGKDSLTTVIDVTDLFSKDVKP 173
Cdd:pfam17148   1 GDKVNEQVIRFEKGGndKLLLLRNVSYRNVAPDSdAAIAKAVKNSNLDPILAAFDIKAYNKDSSAVVIDVTDFFNGDNKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 174 LG-LPDRSRKQYKVTRLDSDLSYIESIKSYPLNIETRHVKTYNAsepPSNATSGAISIELNNSMILLPKVPMKRRIFDQR 252
Cdd:pfam17148  81 FSpLLPRSKNGLGLGSLDSDRSYIESIKAFPDNIEIRSVLTYTV---PGGSSSGPVTVEVNTSLVLLPEEPMKPRLADPR 157

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1816520665 253 VGWFTSGQIDYGLDAHESKRVTYLDRWRLEVK 284
Cdd:pfam17148 158 VGYFTTSYTDFSDDQQKVETKRYITRWRLEPK 189
DUF5118 pfam17162
Domain of unknown function (DUF5118); This domain falls upstream of a met-zincin domain.
 40-89 3.39e-21

Domain of unknown function (DUF5118); This domain falls upstream of a met-zincin domain.


:

Pssm-ID: 435758  Cd Length: 50  Bit Score: 87.20  E-value: 3.39e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1816520665  40 IQPYNKVITKDAVSDPGLFTVHKIDETYFYEIPDSLFEREMLKVTRIAKT 89
Cdd:pfam17162   1 PKPYDKVIKKKAKTKKGLFTVHKKDDKYYFEIPDSLLGRDMLVVTRIAKT 50
 
Name Accession Description Interval E-value
DUF4953 pfam16313
Met-zincin; This is a family of uncharacterized proteins that carry the highly characteriztic ...
 421-727 3.04e-177

Met-zincin; This is a family of uncharacterized proteins that carry the highly characteriztic met-zincin mmotif HExxHxxGxxH, the extended zinc-binding domain of metallopeptidases.


Pssm-ID: 435269  Cd Length: 319  Bit Score: 512.18  E-value: 3.04e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 421 FKDEIMGRLIRFVSSHEVGHTLGLPHNMASSSAYKVDDLRDPEFTKKHGTAPSIMDYARFNYVAQPGDEGV---ALMPNI 497
Cdd:pfam16313   4 FPDELMGALLRFVSAHEVGHTLGLRHNFAASSAYPVDSLRDKSFTRKYGTTPSIMDYARFNYVAQPEDQIDlsgLYPPGI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 498 GVYDKYAIAWGYRPILDAETPEDEKKTLDSWILKHAGDPMYRFGRQQSGGVIDPSSQTEDLGDDAMKASAYGIANLKRIV 577
Cdd:pfam16313  84 GPYDKWAIEWGYRPFPDAKTPEEEKAALDKWAERSAGDPGLRFGTDQDARGADPRAQTEDLGDDAVKASEYGIKNLKRIL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 578 PNLLKWTAE-DGKDYSDLGTMYGEVLGQYNRYMGHVTANIGGVYEIYKTYDQEGDVYTHVDKAKQKEALQFLQKELFTTP 656
Cdd:pfam16313 164 PNLPEWTAEkEGEDYSDLEELYVPVLLQYRRYIGHVAKNIGGVYYNYKVRGDPGPVYTPVPKEKQKEALDFLLKQLFETP 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1816520665 657 EWLLDNDIFNKI--EFDGSLERIRSTQTRTLDNILDFGRMQRMSENETINGKDAYGLLAMMQDLRKGIFSELN 727
Cdd:pfam16313 244 EWLLDPNLLNKTrgLDFDPHDRVEALQSRVLSALLSPGRLNRLVEQEARDGDKAYTLAELLDDLRKGIFKELE 316
ZnMc_MMP_like_2 cd04276
Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase ...
 294-511 1.00e-83

Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239803  Cd Length: 197  Bit Score: 265.34  E-value: 1.00e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 294 GELVEPKKQIVYYIDRATPEQWRKYIKQGIEDWQVAFEAAGFKNAIIAKDPPtieedPDWSPEDARYSVVRYLASPIP-N 372
Cdd:cd04276     1 AALSEPKEPIVYYLDNTFPEKYRDAIREGVLYWNKAFEKAGFKNAIIVKVLP-----DDADPGDIRYNVIRWIHSPNGgW 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 373 ANGPHVSDPRSGEIIESDINWYHNVMTLLRNWFFVQTAAinpeaqsvrfkdeimgrLIRFVSSHEVGHTLGLPHNMASSS 452
Cdd:cd04276    76 AYGPSVVDPRTGEILKADVILYSGFLRQDQLWYEDLLAA-----------------SLRYLLAHEVGHTLGLRHNFKASS 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1816520665 453 AYKVDDLRDPEFTKKHGTAPSIMDYARFNYVAQPGDEGVALMPNIGVYDKYAIAWGYRP 511
Cdd:cd04276   139 DGSNEELEDPLGTKEKGATSSVMDYPPPNVAAQGEDQGDYYPPTIGPYDKWAIEYGYTP 197
DUF5117 pfam17148
Domain of unknown function (DUF5117); This domain may fall upstream of a met-zincin domain.
 97-284 8.02e-77

Domain of unknown function (DUF5117); This domain may fall upstream of a met-zincin domain.


Pssm-ID: 465363  Cd Length: 189  Bit Score: 246.75  E-value: 8.02e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665  97 GGKQDEQVLRWQKKG--KRVLLRMVSHNVVANDT-LPVHEAVVNSNFEPVLFSFPIKAFGKDSLTTVIDVTDLFSKDVKP 173
Cdd:pfam17148   1 GDKVNEQVIRFEKGGndKLLLLRNVSYRNVAPDSdAAIAKAVKNSNLDPILAAFDIKAYNKDSSAVVIDVTDFFNGDNKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 174 LG-LPDRSRKQYKVTRLDSDLSYIESIKSYPLNIETRHVKTYNAsepPSNATSGAISIELNNSMILLPKVPMKRRIFDQR 252
Cdd:pfam17148  81 FSpLLPRSKNGLGLGSLDSDRSYIESIKAFPDNIEIRSVLTYTV---PGGSSSGPVTVEVNTSLVLLPEEPMKPRLADPR 157

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1816520665 253 VGWFTSGQIDYGLDAHESKRVTYLDRWRLEVK 284
Cdd:pfam17148 158 VGYFTTSYTDFSDDQQKVETKRYITRWRLEPK 189
DUF5118 pfam17162
Domain of unknown function (DUF5118); This domain falls upstream of a met-zincin domain.
 40-89 3.39e-21

Domain of unknown function (DUF5118); This domain falls upstream of a met-zincin domain.


Pssm-ID: 435758  Cd Length: 50  Bit Score: 87.20  E-value: 3.39e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1816520665  40 IQPYNKVITKDAVSDPGLFTVHKIDETYFYEIPDSLFEREMLKVTRIAKT 89
Cdd:pfam17162   1 PKPYDKVIKKKAKTKKGLFTVHKKDDKYYFEIPDSLLGRDMLVVTRIAKT 50
 
Name Accession Description Interval E-value
DUF4953 pfam16313
Met-zincin; This is a family of uncharacterized proteins that carry the highly characteriztic ...
 421-727 3.04e-177

Met-zincin; This is a family of uncharacterized proteins that carry the highly characteriztic met-zincin mmotif HExxHxxGxxH, the extended zinc-binding domain of metallopeptidases.


Pssm-ID: 435269  Cd Length: 319  Bit Score: 512.18  E-value: 3.04e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 421 FKDEIMGRLIRFVSSHEVGHTLGLPHNMASSSAYKVDDLRDPEFTKKHGTAPSIMDYARFNYVAQPGDEGV---ALMPNI 497
Cdd:pfam16313   4 FPDELMGALLRFVSAHEVGHTLGLRHNFAASSAYPVDSLRDKSFTRKYGTTPSIMDYARFNYVAQPEDQIDlsgLYPPGI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 498 GVYDKYAIAWGYRPILDAETPEDEKKTLDSWILKHAGDPMYRFGRQQSGGVIDPSSQTEDLGDDAMKASAYGIANLKRIV 577
Cdd:pfam16313  84 GPYDKWAIEWGYRPFPDAKTPEEEKAALDKWAERSAGDPGLRFGTDQDARGADPRAQTEDLGDDAVKASEYGIKNLKRIL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 578 PNLLKWTAE-DGKDYSDLGTMYGEVLGQYNRYMGHVTANIGGVYEIYKTYDQEGDVYTHVDKAKQKEALQFLQKELFTTP 656
Cdd:pfam16313 164 PNLPEWTAEkEGEDYSDLEELYVPVLLQYRRYIGHVAKNIGGVYYNYKVRGDPGPVYTPVPKEKQKEALDFLLKQLFETP 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1816520665 657 EWLLDNDIFNKI--EFDGSLERIRSTQTRTLDNILDFGRMQRMSENETINGKDAYGLLAMMQDLRKGIFSELN 727
Cdd:pfam16313 244 EWLLDPNLLNKTrgLDFDPHDRVEALQSRVLSALLSPGRLNRLVEQEARDGDKAYTLAELLDDLRKGIFKELE 316
ZnMc_MMP_like_2 cd04276
Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase ...
 294-511 1.00e-83

Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239803  Cd Length: 197  Bit Score: 265.34  E-value: 1.00e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 294 GELVEPKKQIVYYIDRATPEQWRKYIKQGIEDWQVAFEAAGFKNAIIAKDPPtieedPDWSPEDARYSVVRYLASPIP-N 372
Cdd:cd04276     1 AALSEPKEPIVYYLDNTFPEKYRDAIREGVLYWNKAFEKAGFKNAIIVKVLP-----DDADPGDIRYNVIRWIHSPNGgW 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 373 ANGPHVSDPRSGEIIESDINWYHNVMTLLRNWFFVQTAAinpeaqsvrfkdeimgrLIRFVSSHEVGHTLGLPHNMASSS 452
Cdd:cd04276    76 AYGPSVVDPRTGEILKADVILYSGFLRQDQLWYEDLLAA-----------------SLRYLLAHEVGHTLGLRHNFKASS 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1816520665 453 AYKVDDLRDPEFTKKHGTAPSIMDYARFNYVAQPGDEGVALMPNIGVYDKYAIAWGYRP 511
Cdd:cd04276   139 DGSNEELEDPLGTKEKGATSSVMDYPPPNVAAQGEDQGDYYPPTIGPYDKWAIEYGYTP 197
DUF5117 pfam17148
Domain of unknown function (DUF5117); This domain may fall upstream of a met-zincin domain.
 97-284 8.02e-77

Domain of unknown function (DUF5117); This domain may fall upstream of a met-zincin domain.


Pssm-ID: 465363  Cd Length: 189  Bit Score: 246.75  E-value: 8.02e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665  97 GGKQDEQVLRWQKKG--KRVLLRMVSHNVVANDT-LPVHEAVVNSNFEPVLFSFPIKAFGKDSLTTVIDVTDLFSKDVKP 173
Cdd:pfam17148   1 GDKVNEQVIRFEKGGndKLLLLRNVSYRNVAPDSdAAIAKAVKNSNLDPILAAFDIKAYNKDSSAVVIDVTDFFNGDNKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 174 LG-LPDRSRKQYKVTRLDSDLSYIESIKSYPLNIETRHVKTYNAsepPSNATSGAISIELNNSMILLPKVPMKRRIFDQR 252
Cdd:pfam17148  81 FSpLLPRSKNGLGLGSLDSDRSYIESIKAFPDNIEIRSVLTYTV---PGGSSSGPVTVEVNTSLVLLPEEPMKPRLADPR 157

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1816520665 253 VGWFTSGQIDYGLDAHESKRVTYLDRWRLEVK 284
Cdd:pfam17148 158 VGYFTTSYTDFSDDQQKVETKRYITRWRLEPK 189
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 300-509 4.34e-41

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 148.03  E-value: 4.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 300 KKQIVYYIDRATPEQWRKYIKQGIEDWQVAFeAAGFKNAIIAkdpptieedpdwSPEDARYSVVRYLASPIP-NANGPHV 378
Cdd:cd04268     1 KKPITYYIDDSVPDKLRAAILDAIEAWNKAF-AIGFKNANDV------------DPADIRYSVIRWIPYNDGtWSYGPSQ 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816520665 379 SDPRSGEIIESDINWYHNVMtllrnwffvqtaainpeaqsvrfkdEIMGRLIRFVSSHEVGHTLGLPHNMASSSAYKVDD 458
Cdd:cd04268    68 VDPLTGEILLARVYLYSSFV-------------------------EYSGARLRNTAEHELGHALGLRHNFAASDRDDNVD 122

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1816520665 459 lrdpeFTKKHGTAPSIMDYARFNYVAQPGDEGvalMPNIGVYDKYAIAWGY 509
Cdd:cd04268   123 -----LLAEKGDTSSVMDYAPSNFSIQLGDGQ---KYTIGPYDIAAIKKLY 165
DUF5118 pfam17162
Domain of unknown function (DUF5118); This domain falls upstream of a met-zincin domain.
 40-89 3.39e-21

Domain of unknown function (DUF5118); This domain falls upstream of a met-zincin domain.


Pssm-ID: 435758  Cd Length: 50  Bit Score: 87.20  E-value: 3.39e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1816520665  40 IQPYNKVITKDAVSDPGLFTVHKIDETYFYEIPDSLFEREMLKVTRIAKT 89
Cdd:pfam17162   1 PKPYDKVIKKKAKTKKGLFTVHKKDDKYYFEIPDSLLGRDMLVVTRIAKT 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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