|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
1-387 |
1.05e-158 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 451.43 E-value: 1.05e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 1 MKERTQLLYSGEMNLPGHiHPDAPAIFPATAYAMQDTQHYFAVSSG-NGEYQYNRTANPNRDSLSAAISLMEDGEVSAVM 79
Cdd:COG0626 1 MGPATRAVHAGRDPDPQT-GAVSPPIYLTSTFVFPSAEALAARFAGeEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 80 ASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKV 159
Cdd:COG0626 80 ASGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 160 VDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCS-QALMQKIELKARLLGGCS 238
Cdd:COG0626 160 VDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRdEELAERLRFLQNALGAVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 239 DPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFlQGCGPMLSFRVADDQTKVD 318
Cdd:COG0626 240 SPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQM-SGFGGMLSFELKGGREAAR 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1816728030 319 AFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:COG0626 319 RFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
23-387 |
3.63e-141 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 406.20 E-value: 3.63e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 23 APAIFPATAYAMQDTQHYFAVSSG-NGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLV 101
Cdd:cd00614 4 APPIYQTSTFVFPSPAEAADLFALrEGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDHVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 102 VNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNT 181
Cdd:cd00614 84 ASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDNT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 182 FSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQ-ALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQ 260
Cdd:cd00614 164 FATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGeALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRMERH 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 261 MENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFLqGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSL 340
Cdd:cd00614 244 SENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMS-GYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVESLV 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1816728030 341 AHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:cd00614 323 EHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
5-387 |
2.84e-128 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 373.49 E-value: 2.84e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 5 TQLLYSGEMNLPGHiHPDAPAIFPATAYAmQDTQhyfavsSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMA 84
Cdd:pfam01053 2 TLAVHAGQRPDPQT-GAVSVPIYLTSTYV-FDFA------GEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 85 AISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDA 164
Cdd:pfam01053 74 AITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 165 IACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCS-QALMQKIELKARLLGGCSDPYTA 243
Cdd:pfam01053 154 IAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNgEELGKELYFLQNATGAVLSPFDA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 244 WLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSlFLQGCGPMLSFRVADDQTKVDAFIRR 323
Cdd:pfam01053 234 WLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKR-QMKGFGGMLSFELKGGLEAAKKFLDN 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1816728030 324 LNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:pfam01053 313 LKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
23-387 |
1.49e-103 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 312.35 E-value: 1.49e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 23 APAIFPATAYAMQDTQH---YFAVS-SGNgeyQYNRTANPNRDSLSAAISLMEDGeVSAV-MASGMAAISATLLSLLRQG 97
Cdd:COG2873 27 AVPIYQTTSYVFDDAEHaadLFALKePGN---IYTRIMNPTTDVLEKRIAALEGG-VAALaTASGQAAITLAILNLAEAG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 98 DHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLV 177
Cdd:COG2873 103 DHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALDVLDIEAIAEIAHEHGVPLI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 178 VDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVtcsqalmqkIE----------------------------- 228
Cdd:COG2873 183 VDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVI---------VDggnfdwaangkfpeltepdpsyhglvyte 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 229 --------LKARL-----LGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAK 295
Cdd:COG2873 254 afgnaafiTKARVqllrdLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLPSHPYHELAQ 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 296 SLFLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAA 375
Cdd:COG2873 334 KYLPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDLIRLSVGIEDI 413
|
410
....*....|..
gi 1816728030 376 EDLIADITQALD 387
Cdd:COG2873 414 DDIIADLDQALA 425
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
24-387 |
1.20e-100 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 303.88 E-value: 1.20e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 24 PAIFPATAYAmQDtqhyfAVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVN 103
Cdd:PRK07811 33 PPIYASSTFA-QD-----GVGGLRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATDCLLRAVLRPGDHIVIP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 104 EAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFS 183
Cdd:PRK07811 107 NDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAELAHDAGAKVVVDNTFA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 184 TPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCS-QALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQME 262
Cdd:PRK07811 187 SPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNdEELDEAFAFLQNGAGAVPGPFDAYLTLRGLKTLAVRMDRHSE 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 263 NAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAH 342
Cdd:PRK07811 267 NAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQ-MRGFGGMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEH 345
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1816728030 343 PATAFRTEFTPQQLidfGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07811 346 PSAMTHASTAGSQL---EVPDDLVRLSVGIEDVADLLADLEQALG 387
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
17-386 |
5.23e-97 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 294.28 E-value: 5.23e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 17 GHIHPDA-----PAIFPATAYAMQDTqhyfAVSSGNG-EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATL 90
Cdd:PRK08574 10 GYRGSDPygslqPPIYLTALFRQEGE----AYPSDRGfDLKYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 91 LSLLRQGDHLVVNEAIYGETIELIDLiLVPLGVAVTYAdFLSPESVQAAIR-PETVMLYTEIISNPLIKVVDIDAIACIS 169
Cdd:PRK08574 86 FSLLKAGDRVVLPMEAYGTTLRLLKS-LEKFGVKVVLA-YPSTEDIIEAIKeGRTKLVFIETMTNPTLKVIDVPEVAKAA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 170 KANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQA-LMQKIELKARLLGGCSDPYTAWLCLR 248
Cdd:PRK08574 164 KELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGeFLEELWEWRRRLGTIMQPFEAYLVLR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 249 SIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFLQGC-GPMLSFRVADDQTKVDAFIRRLNLI 327
Cdd:PRK08574 244 GLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDLyGGVVSFRVKGGRDAVLKFLRSLKLI 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1816728030 328 TYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQAL 386
Cdd:PRK08574 324 KPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQAL 382
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
5-387 |
2.96e-96 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 292.80 E-value: 2.96e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 5 TQLLYSGEMNLPGHIHPDAPaIFPATAYAMQDTQHYFAVSSGNGE-YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGM 83
Cdd:PRK08249 11 TKAVWAGEKEYLPYGATQVP-VVLSVAYGYDDIDEWYDVALGKKPgHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 84 AAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDID 163
Cdd:PRK08249 90 AAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVDIE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 164 AIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQALMQKIELKARLLGGCSDPYTA 243
Cdd:PRK08249 170 RLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCGSKELMEQVYHYREINGATMDPMSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 244 WLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRR 323
Cdd:PRK08249 250 YLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQ-MRGFGGILSFVLKGGMDTVKRLLPK 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1816728030 324 LNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK08249 329 LRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFA 392
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
1-387 |
4.30e-95 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 288.93 E-value: 4.30e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 1 MKERTQLLYSGemnLPGHIHPDA--PAIFPATAYamqdTQHYFAVSSGngeYQYNRTANPNRDSLSAAISLMEDGEVSAV 78
Cdd:PRK07671 1 MRAKTKLIHGG---IIGDPSTGAvsVPIYQVSTY----KQEAVGKHQG---YEYSRTGNPTRAALEELIAVLEGGHAGFA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 79 MASGMAAISATLLsLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIK 158
Cdd:PRK07671 71 FGSGMAAITAVMM-LFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 159 VVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAG-SVTCSQALMQKIELKARLLGGC 237
Cdd:PRK07671 150 ITDIKKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGlVVVNSPELAEDLHFVQNSTGGI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 238 SDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQtKV 317
Cdd:PRK07671 230 LGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQ-ANGFGGMISFDVGSEE-TA 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 318 DAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07671 308 NKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
50-387 |
1.89e-94 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 288.05 E-value: 1.89e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 50 YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYAD 129
Cdd:PRK08133 53 NIYSRFTNPTVTMFQERLAALEGAEACVATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVD 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 130 FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGH 209
Cdd:PRK08133 133 LTDLDAWRAAVRPNTKLFFLETPSNPLTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQ 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 210 SDLTAGSVTCSQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHP 289
Cdd:PRK08133 213 GRVLGGAVVGSKELMEEVFGFLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHP 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 290 QHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRIS 369
Cdd:PRK08133 293 QHELAKRQ-QKGGGAIVSFEVKGGREAAWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVA 371
|
330
....*....|....*...
gi 1816728030 370 AGCEAAEDLIADITQALD 387
Cdd:PRK08133 372 VGLEDVADIKADLARGLA 389
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
5-386 |
7.91e-93 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 284.64 E-value: 7.91e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 5 TQLLYSGEMNLPGHiHPDAPAIFPATAYAMQDTQH---YFAVSS-GNgeyQYNRTANPNRDSLSAAISLMEDGEVSAVMA 80
Cdd:TIGR01326 4 TLQLHAGQEPDPTT-GSRAVPIYQTTSYVFDSTEHaaaLFGLQEpGN---IYSRLMNPTTDVLEQRIAALEGGVAALAVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 81 SGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVV 160
Cdd:TIGR01326 80 SGQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 161 DIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQALMQKIE------------ 228
Cdd:TIGR01326 160 DIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKFDWNNGrfplfttpdpsy 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 229 ---------------LKARL-----LGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASH 288
Cdd:TIGR01326 240 hglvftetlgnpafiLKARVqllrdLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 289 PQHDLAKSLFLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRI 368
Cdd:TIGR01326 320 PHHALAKKYLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRL 399
|
410
....*....|....*...
gi 1816728030 369 SAGCEAAEDLIADITQAL 386
Cdd:TIGR01326 400 SVGIENIDDIIADLEQAL 417
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
50-387 |
4.02e-92 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 282.16 E-value: 4.02e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 50 YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYAD 129
Cdd:TIGR01328 51 YIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFIN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 130 FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGH 209
Cdd:TIGR01328 131 MAIPEEVKAHIKDNTKIVYFETPANPTMKLIDMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGH 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 210 SDLTAGSVTCSQALMQKIELKAR--LLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLAS 287
Cdd:TIGR01328 211 GDVVAGLICGKAELLQQIRMVGIkdMTGSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFED 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 288 HPQHDLAKSLFLQGcGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIR 367
Cdd:TIGR01328 291 HPGHDIAAKQMRMG-GGMITFELKGGFAGAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIR 369
|
330 340
....*....|....*....|
gi 1816728030 368 ISAGCEAAEDLIADITQALD 387
Cdd:TIGR01328 370 LSVGLEDADDLIADLKQALD 389
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
50-387 |
3.14e-91 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 280.17 E-value: 3.14e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 50 YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYAD 129
Cdd:PRK06234 56 YIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVD 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 130 FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKAN--DCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFG 207
Cdd:PRK06234 136 TSNLEEVRNALKANTKVVYLETPANPTLKVTDIKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLN 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 208 GHSDLTAGSVTCSQALMQKIELKA--RLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGL 285
Cdd:PRK06234 216 GHGDVIAGFVVGKEEFINQVKLFGikDMTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGL 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 286 ASHPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGL 365
Cdd:PRK06234 296 ESFEYYELAKKQ-MSLPGAMISFELKGGVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGL 374
|
330 340
....*....|....*....|..
gi 1816728030 366 IRISAGCEAAEDLIADITQALD 387
Cdd:PRK06234 375 VRLSVGLEDVDDIIADLKQALD 396
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
24-387 |
3.31e-91 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 280.15 E-value: 3.31e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 24 PAIFPATAYAMQDTQHYFAVSSGNGE-YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVV 102
Cdd:PRK07503 30 PPVYLTATFAFPTAEYGAECFAGEEEgHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAITATLWTLLRPGDEVIV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 103 NEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTF 182
Cdd:PRK07503 110 DQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDIAAVAEIAHGAGAKVVVDNTY 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 183 STPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQALMQKIELKA--RLLGGCSDPYTAWLCLRSIRTMEMRVSRQ 260
Cdd:PRK07503 190 CTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRIRLEGlkDMTGAVMSPFDAFLLMRGLKTLALRMDRH 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 261 MENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFLQGcGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSL 340
Cdd:PRK07503 270 CASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALP-GGMIAFELKGGIAAGRRFMNALQLFARAVSLGDAESLA 348
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1816728030 341 AHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07503 349 QHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALD 395
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
1-390 |
5.71e-90 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 275.94 E-value: 5.71e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 1 MKERTQLLYSGEMNLPGHIhpdAPAIFPATAYamqdtqHYfavsSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMA 80
Cdd:PRK06460 1 MKDATRTVREDIDEATGAI---TTPIYQTTAY------HY----PEGEKYRYSREANPTVLELTKKIVELENAEMGVAFS 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 81 SGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVV 160
Cdd:PRK06460 68 SGMGAISTTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 161 DIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQALMQKIELKARLLGGCSDP 240
Cdd:PRK06460 148 DITELSKVCKENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLLNVIDQMRRTLGTSLDP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 241 YTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAF 320
Cdd:PRK06460 228 HAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRV-LKGFGGVLSFEVNGGQESALKV 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 321 IRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALDVFN 390
Cdd:PRK06460 307 MKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALSTLY 376
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
37-387 |
9.82e-90 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 275.88 E-value: 9.82e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 37 TQHYFAVSSgNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLsLLRQGDHLVVNEAIYGETIELIDL 116
Cdd:PRK08064 34 TFHQFDFDT-FGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAFL-LLSKGDHVLISEDVYGGTYRMITE 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 117 ILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGAD 196
Cdd:PRK08064 112 VLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGAD 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 197 IVIHSLTKFFGGHSDLTAG-SVTCSQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDP 275
Cdd:PRK08064 192 VVLHSATKFLAGHSDVLAGlAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHP 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 276 RVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQTkVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQ 355
Cdd:PRK08064 272 KVQNVYYPGLQTHLGFDIQQSQ-ATSAGAVLSFTLQSEEA-VRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEE 349
|
330 340 350
....*....|....*....|....*....|..
gi 1816728030 356 LIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK08064 350 RDERGITDGLLRLSVGLENVDDLIADFEQALS 381
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
23-386 |
8.52e-88 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 270.03 E-value: 8.52e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 23 APAIFPATAYAmqdtqHyfavsSGNGE---YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISaTLLSLLRQGDH 99
Cdd:PRK08247 24 NPPVYFSTAYR-----H-----EGIGEstgFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQ-LVMSLFRSGDE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 100 LVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVD 179
Cdd:PRK08247 93 LIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKHGLLLIVD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 180 NTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAG-SVTCSQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVS 258
Cdd:PRK08247 173 NTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGlVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRGMKTLALRMR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 259 RQMENAQRIAEALSSDPRVAQVNYPGLashpqhdlakslflqgcGPMLSFRVAdDQTKVDAFIRRLNLITYLGTLGGFRT 338
Cdd:PRK08247 253 QHEENAKAIAAFLNEQPGVTDVLYPGR-----------------GGMLSFRLQ-DEEWVNPFLKSLKLITFAESLGGVES 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1816728030 339 SLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQAL 386
Cdd:PRK08247 315 FITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAF 362
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
49-386 |
1.83e-87 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 269.85 E-value: 1.83e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 49 EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISAtLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYA 128
Cdd:PRK06176 41 GYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA-VFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTII 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 129 DFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGG 208
Cdd:PRK06176 120 DTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGG 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 209 HSDLTAGSVTC-SQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLAS 287
Cdd:PRK06176 200 HSDVVAGLVTTnNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPT 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 288 HPQHDLAKSLfLQGCGPMLSFRVADDQtKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIR 367
Cdd:PRK06176 280 HPNHELAKKQ-MRGFSGMLSFTLKNDS-EAVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVR 357
|
330
....*....|....*....
gi 1816728030 368 ISAGCEAAEDLIADITQAL 386
Cdd:PRK06176 358 LSVGIEHEQDLLEDLEQAF 376
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
25-387 |
2.92e-86 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 267.32 E-value: 2.92e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 25 AIFPATAYAMQDTQHYFAVSSGN-GEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVN 103
Cdd:PRK05939 13 PIHTSVTYGYEDARDLIDVFQGKkPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDHLVSS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 104 EAIYGETIELIDlILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFS 183
Cdd:PRK05939 93 QFLFGNTNSLFG-TLRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 184 TPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVT---------------------CSQALMQKIELKA-RLLGGCSDPY 241
Cdd:PRK05939 172 SPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdtglfdwsaypnifpayrkgdPQQWGLTQIRKKGlRDMGATLSSE 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 242 TAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFlQGCGPMLSFRVADDQTKVDaFI 321
Cdd:PRK05939 252 AAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELF-RHYGGLLSFELADGIDCFD-FL 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1816728030 322 RRLNLITYLGTLGGFRTsLAHPA--TAFrTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK05939 330 NRLKLVIKATHLGDTRT-LVIPVapTIY-YEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALD 395
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
23-386 |
4.95e-83 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 260.07 E-value: 4.95e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 23 APAIFPATAYAMQDTQHYFAVSS----GNgeyQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGD 98
Cdd:PRK07812 33 ALPIYQTTSYTFDDTDHAAALFGlaepGN---IYTRIMNPTQDVVEQRIAALEGGVAALLLASGQAAETFAILNLAGAGD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 99 HLVVNEAIYGETIELIDLILVPLGVAVTY-ADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLV 177
Cdd:PRK07812 110 HIVSSPRLYGGTYNLFHYTLPKLGIEVSFvEDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLDIPGVAEVAHEAGVPLI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 178 VDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVT--------------------------------CSQALMQ 225
Cdd:PRK07812 190 VDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVdggtfdwtqgrfpgfttpdpsyhgvvfaelgpPAYALKA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 226 KIELkARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFLQGCGPM 305
Cdd:PRK07812 270 RVQL-LRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPWYERAKRLAPKGTGAV 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 306 LSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQA 385
Cdd:PRK07812 349 LSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAVGIEGIDDILADLEAG 428
|
.
gi 1816728030 386 L 386
Cdd:PRK07812 429 F 429
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
49-386 |
6.25e-82 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 255.50 E-value: 6.25e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 49 EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDlILVPLGV-AVTY 127
Cdd:TIGR02080 42 AYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVTTALLGPDDLLVAPHDCYGGTYRLLN-ALAKKGCfRVLF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 128 ADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFG 207
Cdd:TIGR02080 121 VDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVGAVVVVDNTFLSPALQNPLALGADLVLHSCTKYLN 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 208 GHSDLTAGSVTCSQA-LMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLA 286
Cdd:TIGR02080 201 GHSDVIAGAVIAKDPqVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLP 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 287 SHPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLI 366
Cdd:TIGR02080 281 DHPGHEIAARQ-QKGFGAMLSFELKGGEQTVRRFLGGLSLFTLAESLGGVESLIAHPATMTHAAMGPEARAEAGISDTLL 359
|
330 340
....*....|....*....|
gi 1816728030 367 RISAGCEAAEDLIADITQAL 386
Cdd:TIGR02080 360 RLSVGLEDADDLIADLEQGL 379
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
21-388 |
8.46e-82 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 254.54 E-value: 8.46e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 21 PDAPAIFPATAYamqdtqhYFAVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVsAVMASGMAAISATLLSLLRQGDHL 100
Cdd:PRK07582 21 PVLPGPVFAAPY-------HLSPGEPTGPDTYGRASNPTWRALEAALGELEGAEA-LVFPSGMAAITAVLRALLRPGDTV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 101 VVNEAIYGETIELIDLILVPLGVAVTYADflSPESVQAAIRPETVMLyTEIISNPLIKVVDIDAIACISKANDCLLVVDN 180
Cdd:PRK07582 93 VVPADGYYQVRALAREYLAPLGVTVREAP--TAGMAEAALAGADLVL-AETPSNPGLDVCDLAALAAAAHAAGALLVVDN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 181 TFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQA-LMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSR 259
Cdd:PRK07582 170 TTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPeLMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFAR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 260 QMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAkSLFLQGCGPMLSFRVADDQtKVDAFIRRLNLITYLGTLGGFRTS 339
Cdd:PRK07582 250 QCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVA-ARQMRRFGGLVSFELADAA-AAERFVAASRLVVAATSFGGVHTS 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1816728030 340 LAHPATafrteftpqqlidFGMH--EGLIRISAGCEAAEDLIADITQALDV 388
Cdd:PRK07582 328 ADRRAR-------------WGDAvpEGFVRLSCGIEDTDDLVADLERALDA 365
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
23-387 |
2.44e-81 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 254.00 E-value: 2.44e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 23 APAIFPATAYAMQDTQHYFAVSSGNGE-YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLV 101
Cdd:PRK06767 25 TPPLFQTSTFTFETAQQGEASFAGVDPsYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSGMAAISATLIGFLKAGDHII 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 102 VNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNT 181
Cdd:PRK06767 105 CSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDLKQVIRVAKRNGLLVIVDNT 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 182 FSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQALMQKIELKARL-LGGCSDPYTAWLCLRSIRTMEMRVSRQ 260
Cdd:PRK06767 185 FCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKdIGGIMAPFDAWLLLRGLKTLAVRMDRH 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 261 MENAQRIAEALSSDPRVAQVNYpglashPQHDLAKSLFLQGcGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSL 340
Cdd:PRK06767 265 CDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRG-GGVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLI 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1816728030 341 AHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK06767 338 QHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
20-386 |
1.07e-80 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 253.89 E-value: 1.07e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 20 HPD------APAIFPATAYAMQDTQHyfAVSSGNGE---YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATL 90
Cdd:PRK08134 19 APDpatgarAVPIHLTTSFVFRDSDH--AAALFNLEragHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAALHLAI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 91 LSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISK 170
Cdd:PRK08134 97 ATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDIPTVAAIAH 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 171 ANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHS----------------------DLTA------GSVTCSQA 222
Cdd:PRK08134 177 EAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGtaiggvlvdggrfdweasgkfpELTEpyagfhGMVFAEES 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 223 LMQKIELKARL-----LGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSL 297
Cdd:PRK08134 257 TVAAFLLRARReglrdFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDHALAKRL 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 298 FLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAED 377
Cdd:PRK08134 337 LPRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLSIGLEDADD 416
|
....*....
gi 1816728030 378 LIADITQAL 386
Cdd:PRK08134 417 LIDDLKRAL 425
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
49-386 |
2.25e-79 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 249.91 E-value: 2.25e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 49 EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYA 128
Cdd:PRK08776 51 QYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 129 DFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGG 208
Cdd:PRK08776 131 DLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYING 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 209 HSDLTAGSVTCSQ-ALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLAS 287
Cdd:PRK08776 211 HSDVVGGAVVARDaELHQQLVWWANALGLTGSPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLAS 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 288 HPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIR 367
Cdd:PRK08776 291 HPGHALAARQ-QKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLR 369
|
330
....*....|....*....
gi 1816728030 368 ISAGCEAAEDLIADITQAL 386
Cdd:PRK08776 370 LSVGIESAEDLLIDLRAGL 388
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
5-386 |
4.25e-77 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 242.81 E-value: 4.25e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 5 TQLLYSGEMNLPghIHPDAPAIFPATAYAMQDtqhyfavSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMA 84
Cdd:TIGR01329 3 TLLVNTDNKNDP--YDASSMPIYQTATFKQPL-------AIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 85 AISaTLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDA 164
Cdd:TIGR01329 74 ALD-VITRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 165 IACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGsVTC--SQALMQKIELKARLLGGCSDPYT 242
Cdd:TIGR01329 153 ISEMAHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAG-VLAvkGEEIAKKVYFLQNSTGSGLAPFD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 243 AWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSlFLQGCGPMLSFRVADDQTKvDAFIR 322
Cdd:TIGR01329 232 CWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFS-QAKGAGSVLSFETGSVALS-KRLVE 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1816728030 323 RLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQAL 386
Cdd:TIGR01329 310 ATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAF 373
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
52-387 |
1.70e-74 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 237.65 E-value: 1.70e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 52 YNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGV-AVTYADF 130
Cdd:PRK07049 77 YSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVgAVGFADG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 131 LSPESVQAAI-----RPETVMLYTEIISNPLIKVVDIDAIACISKA------NDCLLVVDNTFSTPFVIKPLQHGADIVI 199
Cdd:PRK07049 157 LSEAAIGAAAeaaaaKGRVSLILIETPANPTNSLVDVAAVRRVADAiearqgHRPIIACDNTLLGPVFQKPLEHGADLSV 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 200 HSLTKFFGGHSDLTAGSVTCSQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQ 279
Cdd:PRK07049 237 YSLTKYVGGHSDLVAGAVLGRKALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEK 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 280 VNYPGLasHPQHDLAKSLFLQGC---GPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQL 356
Cdd:PRK07049 317 LHYLPF--LDPDSAYGAVYKRQCtgaGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVR 394
|
330 340 350
....*....|....*....|....*....|.
gi 1816728030 357 IDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07049 395 ERIGVLESTIRLSIGIEHPDDLIADLAQALD 425
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
5-387 |
2.70e-74 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 236.19 E-value: 2.70e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 5 TQLLYSGEMNLPghihpdapaiFPATAYAMQDTQHYFAVSSGNGE---------YQYNRTANPNRDSLSAAISLMEDGEV 75
Cdd:PRK07504 13 TRLVHSGTLRSQ----------FGETSEALFLTQGFVYDTAEAAEarfkgedpgFIYSRYSNPTVDMFEKRMCALEGAED 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 76 SAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNP 155
Cdd:PRK07504 83 ARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 156 LIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQALMQ-KIELKARLL 234
Cdd:PRK07504 163 TLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEeHLQDYFRHT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 235 GGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFRVADDQ 314
Cdd:PRK07504 243 GPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQ-MTGGSTLVAFELKGGK 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1816728030 315 TKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07504 322 EAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALK 394
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
23-386 |
3.69e-72 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 232.04 E-value: 3.69e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 23 APAIFPATAYAMQDTQH---YFAVSS-GNgeyQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGD 98
Cdd:PRK08248 28 AVPIYQTTSYGFRDSEHaanLFSLKEfGN---IYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQAAITYSILNIASAGD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 99 HLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVV 178
Cdd:PRK08248 105 EIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDIEAVAAIAHEHGIPLIV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 179 DNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAG---------------------------SVTCSQAL-MQKIELK 230
Cdd:PRK08248 185 DNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGvivdsgkfdwkgsgkfpgltepdpsyhGLVYTDAVgEAAYITK 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 231 ARL-----LGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFLQGCGPM 305
Cdd:PRK08248 265 ARVqllrdLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHPSYELAKKYLPKGQGAI 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 306 LSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQA 385
Cdd:PRK08248 345 LTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRLSVGTEAIDDILDDLRQA 424
|
.
gi 1816728030 386 L 386
Cdd:PRK08248 425 I 425
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
47-389 |
1.11e-70 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 229.14 E-value: 1.11e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 47 NGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISAtLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVT 126
Cdd:PLN02509 122 NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSA-VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVK 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 127 YADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFF 206
Cdd:PLN02509 201 RVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFI 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 207 GGHSDLTAGSVTCS-QALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGL 285
Cdd:PLN02509 281 AGHSDVMAGVLAVKgEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGL 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 286 ASHPQHDLAKSLfLQGCGPMLSFRVAD--------DQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEftpqqli 357
Cdd:PLN02509 361 PDHPGHHLHFSQ-AKGAGSVFSFITGSvalskhlvETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREAR------- 432
|
330 340 350
....*....|....*....|....*....|..
gi 1816728030 358 dfGMHEGLIRISAGCEAAEDLIADITQALDVF 389
Cdd:PLN02509 433 --GLTEDLVRISAGIEDVDDLISDLDIAFRTG 462
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
10-387 |
6.86e-68 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 220.90 E-value: 6.86e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 10 SGEMNLPghihpdapaIFPATAYAMQDTQH---YFAVSSGNGeyQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAI 86
Cdd:PRK05613 29 TSARNLP---------IYQTTSYVFDSAEHakqRFALEDLGP--IYSRLTNPTVEALENRIASLEGGVHAVAFASGQAAE 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 87 SATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYA-DFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAI 165
Cdd:PRK05613 98 TAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVLDIPAV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 166 ACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFF-------------GGHSDLTA---------GSVTCSQAL 223
Cdd:PRK05613 178 AEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYtgngsglggvlidGGKFDWTVerdgkpvfpYFVTPDPAY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 224 ---------MQKIELKAR--LL---GGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHP 289
Cdd:PRK05613 258 hglkyadlgAPAFGLKARagLLrdtGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLKDSP 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 290 QHDLAKSLFLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRIS 369
Cdd:PRK05613 338 WYATKEKLGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQATVRLS 417
|
410
....*....|....*...
gi 1816728030 370 AGCEAAEDLIADITQALD 387
Cdd:PRK05613 418 VGIEDIDDIIADLEGGFA 435
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
23-386 |
9.07e-68 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 220.35 E-value: 9.07e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 23 APAIFPATAYAMQDTQH---YFAVSS-GNgeyQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGD 98
Cdd:PRK05994 27 ATPIYQTTSFVFNDADHaasLFGLQAfGN---IYTRITNPTNAVLEERVAALEGGTAALAVASGHAAQFLVFHTLLQPGD 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 99 HLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVV 178
Cdd:PRK05994 104 EFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDIAAIAEVAHRAGLPLIV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 179 DNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSD------LTAGSVTCSQ----------------------------ALM 224
Cdd:PRK05994 184 DNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNsmggiiVDGGTFDWSKsgkypmlseprpeyhglvlhetfgnfafAIA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 225 QKIeLKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFLQGCGP 304
Cdd:PRK05994 264 ARV-LGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDPYHALAQKYSPKGAGA 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 305 MLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQ 384
Cdd:PRK05994 343 VFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLSIGIEDVDDIIADLEQ 422
|
..
gi 1816728030 385 AL 386
Cdd:PRK05994 423 AL 424
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
15-388 |
3.22e-66 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 215.33 E-value: 3.22e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 15 LPGHIHPDA-----PAIFPATAYAMQDTQHYFAVSSGNG-EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISA 88
Cdd:PRK05968 14 ITAHDEGNAfdavvPPIFQTSLFTFDSYDEMEDVYAGEKvRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 89 TLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIrPETVMLYTEIISNPLIKVVDIDAIACI 168
Cdd:PRK05968 94 TVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAALAAL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 169 SKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQALMQKIELKAR-LLGGCSDPYTAWLCL 247
Cdd:PRK05968 173 AKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYpYLGAKLSPFEAWLLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 248 RSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAkslflqGCGPMLSFRVADDqTKVDAFIRRLNLI 327
Cdd:PRK05968 253 RGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGLS------GTSGLFSFIFREG-IDVRAFADALKLF 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1816728030 328 TyLGTLGGFRTSLAHPA-TAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALDV 388
Cdd:PRK05968 326 R-LGVSWGGHESLVVPAeVVLQQKAQPNSAARFGVSPRSVRLHVGLEGTEALWADLEQALAA 386
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
5-387 |
5.43e-66 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 214.38 E-value: 5.43e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 5 TQLLYSGEMNLPGHIHPDAPaIFPATAYAMQDTQ-HYFAVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGM 83
Cdd:PRK06434 11 TRAVQSGELRDPRFGNVTTP-IFETSTFVYPNSEkEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 84 AAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVtyaDFLSPESVQAA-IRPETV-MLYTEIISNPLIKVVD 161
Cdd:PRK06434 90 GAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHV---DYIDTDRLNSLdFDPSNYdLIYAESITNPTLKVPD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 162 IDAIACISKANDclLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSV-TCSQALMQKIELKARLLGGCSDP 240
Cdd:PRK06434 167 IKNVSSFCHEND--VIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAgTNNKSIFNNLVERRKTLGSNPDP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 241 YTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLashpqhDLAKSLfLQGCGPMLSFRVADDQtKVDAF 320
Cdd:PRK06434 245 IQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKV-LRGFGGMLSFELRSME-DVHKF 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1816728030 321 IRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK06434 317 IRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALS 383
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
23-387 |
2.61e-64 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 211.30 E-value: 2.61e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 23 APAIFPATAYAMQDTQH---YFAVS-SGNgeyQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGD 98
Cdd:PRK06084 22 AVPIYQTTSYAFDDTQHgadLFDLKvPGN---IYTRIMNPTNDVLEQRVAALEGGVGALAVASGMAAITYAIQTIAEAGD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 99 HLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVV 178
Cdd:PRK06084 99 NIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQALADAAHRHGVPLIV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 179 DNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCS-----QALMQKIEL------------------KARLLG 235
Cdd:PRK06084 179 DNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSgkfpwAEHKERFALlntpdpsyhgvtyteafgPAAFIG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 236 GCS-----------DPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFLQGCGP 304
Cdd:PRK06084 259 RCRvvplrnmgaalSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHPEHELARRYMGGKPAS 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 305 MLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQ 384
Cdd:PRK06084 339 ILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRLSIGIEHIDDIIADLAQ 418
|
...
gi 1816728030 385 ALD 387
Cdd:PRK06084 419 ALD 421
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
15-386 |
5.23e-64 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 209.98 E-value: 5.23e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 15 LPGHIHPDAPAI--------FPATAYAMQDTQHYF------AVSSGNGE---YQYNRTANPNRDSLSAAISLMEDGEVSA 77
Cdd:PRK07810 10 LPDGVSQATIGVrggllrsgFEETAEALYLTSGYVyesaaaAEAAFTGEldrFVYSRYGNPTVSMFEERLRLIEGAEACF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 78 VMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLI 157
Cdd:PRK07810 90 ATASGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 158 KVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCS--------QALMqkiel 229
Cdd:PRK07810 170 SLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDreyidgpvQKLM----- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 230 kaRLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLfLQGCGPMLSFR 309
Cdd:PRK07810 245 --RHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQ-MSGGGTVVTFE 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 310 VA--DDQTKVDAF--IRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIADITQA 385
Cdd:PRK07810 322 LDapEDAAKKRAFevLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRA 401
|
.
gi 1816728030 386 L 386
Cdd:PRK07810 402 L 402
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
49-385 |
7.10e-64 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 208.98 E-value: 7.10e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 49 EYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYA 128
Cdd:PRK08861 44 KYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 129 DFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGG 208
Cdd:PRK08861 124 DQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYING 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 209 HSDLTAGSVTC-SQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLAS 287
Cdd:PRK08861 204 HSDVIGGVLITkTKEHAEELAWWGNCIGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPE 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 288 HPQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIR 367
Cdd:PRK08861 284 HPGHEIAKKQ-QSGFGSMLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLR 362
|
330
....*....|....*...
gi 1816728030 368 ISAGCEAAEDLIADITQA 385
Cdd:PRK08861 363 LSVGLEDAQDLIADLDQA 380
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
50-386 |
2.58e-63 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 207.44 E-value: 2.58e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 50 YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYAD 129
Cdd:PRK08045 44 HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVD 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 130 FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGH 209
Cdd:PRK08045 124 QGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGH 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 210 SDLTAGSVTCSQA-LMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASH 288
Cdd:PRK08045 204 SDVVAGVVIAKDPdVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPEN 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 289 PQHDLAKSLfLQGCGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRI 368
Cdd:PRK08045 284 QGHEIAARQ-QKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRI 362
|
330
....*....|....*...
gi 1816728030 369 SAGCEAAEDLIADITQAL 386
Cdd:PRK08045 363 STGIEDGEDLIADLENGF 380
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
47-387 |
7.37e-60 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 198.18 E-value: 7.37e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 47 NGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVT 126
Cdd:TIGR01324 39 KGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDIT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 127 YADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFF 206
Cdd:TIGR01324 119 YYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 207 GGHSDLTAGSVTCSQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLA 286
Cdd:TIGR01324 199 VGHSDIMIGTVVANARTWDQLREHSYLMGQMVDADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALP 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 287 SHPQHDLAKSLFLQGCGpMLSFRVAD-DQTKVDAFIRRLNLITYLGTLGGFRtSLAHPAtafRTEFTPQQLIDFGMHEGL 365
Cdd:TIGR01324 279 SCPGHEFWKRDFSGSSG-LFSFVLQRlTQKQVHAFLDHLQLFGLGYSWGGYE-SLALCN---QPELGHRPNIKRNLEGPL 353
|
330 340
....*....|....*....|..
gi 1816728030 366 IRISAGCEAAEDLIADITQALD 387
Cdd:TIGR01324 354 IRVHIGLENVDDLKADLKAGFE 375
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
42-386 |
2.11e-58 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 195.03 E-value: 2.11e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 42 AVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPL 121
Cdd:PRK05967 48 TMATRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 122 GVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHS 201
Cdd:PRK05967 128 GVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHA 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 202 LTKFFGGHSDLTAGSVTCSQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVN 281
Cdd:PRK05967 208 ATKYPSGHSDILLGTVSANEKCWPQLLEAHGTLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 282 YPGLASHPQHDLAKSLFlQGCGPMLSFRVADD----QTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTeftpqqlI 357
Cdd:PRK05967 288 HPALPSFPGHEIWKRDF-SGASGIFSFVLAAGpekgKAKAHAFLDALEIFGLGYSWGGYESLALHVKLGDRT-------V 359
|
330 340 350
....*....|....*....|....*....|
gi 1816728030 358 DFGMHEG-LIRISAGCEAAEDLIADITQAL 386
Cdd:PRK05967 360 AKAPYAGpVIRLQIGLEDVPDLKADLERGF 389
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
47-371 |
2.23e-58 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 195.75 E-value: 2.23e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 47 NGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILvP--LGVA 124
Cdd:PLN02242 65 RDFYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFL-PrkCNIT 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 125 VTYADFLSPESVQAAIRP-ETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFsTPFVIKPLQHGADIVIHSLT 203
Cdd:PLN02242 144 TTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTF-APMVLSPARLGADVVVHSIS 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 204 KFFGGHSDLTAGSVTCSQAL---MQKIELKA-RLLGGCSDPYTAW-LCLR----SIRtMEMRVSRQMENAQRIAEaLSsd 274
Cdd:PLN02242 223 KFISGGADIIAGAVCGPAELvnsMMDLHHGAlMLLGPTMNPKVAFeLSERlphlSLR-MKEHCRRAMEYAKRMKE-LG-- 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 275 prvAQVNYPGLASHPQHDLAKSLFLQ--GCGPMLSFRVaDDQTKVDAFIRRLNLITYLG----TLGGFRTSLAHPATAFR 348
Cdd:PLN02242 299 ---LKVIYPGLEDHPQHALLKSMANKgyGFGGLLCLDM-DTEERANRLMRYLQNSTQFGfmavSLGYYETLMSCSGSSTS 374
|
330 340
....*....|....*....|...
gi 1816728030 349 TEFTPQQLIDFGMHEGLIRISAG 371
Cdd:PLN02242 375 SELDPEEKAAAGISPGLVRMSVG 397
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
38-387 |
1.42e-57 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 191.96 E-value: 1.42e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 38 QH-YFAVSSGngeYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAIsATLLSLLRQGDHLVVNEAIYGETIELIDL 116
Cdd:PRK07269 36 QHpEFGQSTG---FDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAI-VLAFSVFPVGSKVVAVRDLYGGSFRWFNQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 117 ILVPLGVAVTYADflSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGAD 196
Cdd:PRK07269 112 QEKEGRFHFTYAN--TEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGAD 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 197 IVIHSLTKFFGGHSDLTAGSV-TCSQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDP 275
Cdd:PRK07269 190 IVLHSATKYLSGHNDVLAGVVvTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSP 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 276 RVAQVNYPGLashpqhdlakslflqgcGPMLSFRVAdDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQ 355
Cdd:PRK07269 270 AVKEVLYTGK-----------------GGMISFKVA-DETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEV 331
|
330 340 350
....*....|....*....|....*....|..
gi 1816728030 356 LIDFGMHEGLIRISAGCEAAEDLIADITQALD 387
Cdd:PRK07269 332 RHSYGLTDDLLRLSIGIEDARDLIADLKQALE 363
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
24-390 |
3.31e-57 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 191.87 E-value: 3.31e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 24 PAIFPATAY---AMQDTQHYfAVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHL 100
Cdd:PRK09028 25 PPVFRASTVvfdTVAEMRHA-AKNRANGEMFYGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISNALLSFLKAGDHL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 101 VVNEAIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDN 180
Cdd:PRK09028 104 LMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDN 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 181 TFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVTCSQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQ 260
Cdd:PRK09028 184 TWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKHWDQLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQH 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 261 MENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFlQGCGPMLSFRVADDQTK-VDAFIRRLNLITYLGTLGGFRT- 338
Cdd:PRK09028 264 EKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDF-SGSNGLFSFVLKQGDPKaVTALVEGMQHFKMGFSWGGFESl 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1816728030 339 SLAHPA-TAFRTEFTPqqliDFgmhEG-LIRISAGCEAAEDLIADITQALDVFN 390
Cdd:PRK09028 343 ILGVFGiNKLRTATNW----DF---SKpLIRLHIGLEDVDDLIADLEAGFERYN 389
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
50-386 |
2.28e-51 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 176.45 E-value: 2.28e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 50 YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAVTYAD 129
Cdd:PRK07050 57 WRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYD 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 130 FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGH 209
Cdd:PRK07050 137 PLIGAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 210 SDLTAGSV-TCSQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASH 288
Cdd:PRK07050 217 SDVLMGATiTADAELHAKLKLARMRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDC 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 289 PQHDLAKSLFlQGCGPMLS--FRVADDQTKVDAFIRRLNLITyLGTLGGFRTSLA--HPATAFRTEFTPqqlidfgmHEG 364
Cdd:PRK07050 297 PGHAFWMRDF-TGAGGLFSvvFDERYSPAQVDAFVEALELFA-IGWSWGGACSLAmpYDVASMRTAKWP--------HRG 366
|
330 340
....*....|....*....|...
gi 1816728030 365 -LIRISAGCEAAEDLIADITQAL 386
Cdd:PRK07050 367 tLVRLYIGLEDEADLIADLEQAL 389
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
16-386 |
7.45e-49 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 171.00 E-value: 7.45e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 16 PGHIHPDAPAIFPATAYAMQDTQHYFAVSSGNGE-YQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLL 94
Cdd:PRK06702 18 PKNGEPRVLPLYQSTTYKYDTSDDLAALFNLEAEgYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAVLNIC 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 95 RQGDHLVVNEAIYGETIELIDLILVPLGVAVTYAD-FLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAIACISKAND 173
Cdd:PRK06702 98 SSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNpNLTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 174 CLLVVDNTFSTPFVIKPLQHGADIVIHSLTKFFGGHSDLTAGSVT-------CSQALMQKIE------------------ 228
Cdd:PRK06702 178 VPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwTNGKYPELVEpdpsyhgvsyvqnfgaaa 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 229 --LKARL-----LGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYPGLASHPQHDLAKSLFLQG 301
Cdd:PRK06702 258 yiVKARVqllrdYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYLKKG 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 302 CGPMLSFRVADDQTKVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDFGMHEGLIRISAGCEAAEDLIAD 381
Cdd:PRK06702 338 ASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIAD 417
|
....*
gi 1816728030 382 ITQAL 386
Cdd:PRK06702 418 LEAAL 422
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
46-383 |
8.66e-46 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 161.79 E-value: 8.66e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 46 GNGEYQYNRTANPNRDSLSAAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDLILVPLGVAV 125
Cdd:PRK08114 50 ANGELFYGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 126 TYADFLSPESVQAAIRPETVMLYTEIISNPLIKVVDIDAI--ACISKANDCLLVVDNTFSTPFVIKPLQHGADIVIHSLT 203
Cdd:PRK08114 130 TWFDPLIGADIAKLIQPNTKVVFLESPGSITMEVHDVPAIvaAVRSVNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGT 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 204 KFFGGHSDLTAGSVTCSQALMQKIELKARLLGGCSDPYTAWLCLRSIRTMEMRVSRQMENAQRIAEALSSDPRVAQVNYP 283
Cdd:PRK08114 210 KYLVGHSDAMIGTAVANARCWEQLRENSYLMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHP 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 284 GLASHPQHDLAKSLFlQGCGPMLSF----RVADDQtkVDAFIRRLNLITYLGTLGGFRTSLAHPATAFRTEFTPQQLIDF 359
Cdd:PRK08114 290 ALPGCKGHEFWKRDF-TGSSGLFSFvlkkKLTDEQ--LANYLDNFSLFSMAYSWGGFESLILANQPEEIAAIRPAGEVDF 366
|
330 340
....*....|....*....|....*
gi 1816728030 360 gmhEG-LIRISAGCEAAEDLIADIT 383
Cdd:PRK08114 367 ---TGtLIRLHIGLEDVDDLIADLA 388
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
78-208 |
5.87e-09 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 55.08 E-value: 5.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 78 VMASGMAAISATLLSLLRQGDHLVVN----EAIYGETIELIDLILVPLGVAVTYADFLSP-ESVQAAIRPETVMLYTEII 152
Cdd:cd01494 22 FVPSGTGANEAALLALLGPGDEVIVDanghGSRYWVAAELAGAKPVPVPVDDAGYGGLDVaILEELKAKPNVALIVITPN 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 153 SNPLIKVVDIDAIACISKANDCLLVVDNTFSTPFVIKPLQH----GADIVIHSLTKFFGG 208
Cdd:cd01494 102 TTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGVLipegGADVVTFSLHKNLGG 161
|
|
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
33-208 |
5.86e-08 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 54.34 E-value: 5.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 33 AMQDTQ---HYFAVSSGngeYQYNRTAnpnRDSLS---AAISLMEDGEVSAVMASGMAAISATLLSLLRQGDHLVvneAI 106
Cdd:COG4100 35 AFQKNRvsdSHFAGTTG---YGYDDIG---RDTLErvyADVFGAEDALVRPQIVSGTHAIALALFGVLRPGDELL---SI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 107 YGE---TIE------------LIDlilvpLGVAVTYADFLS-----PESVQAAIRPETVMLYteiI-------SNPLIKV 159
Cdd:COG4100 106 TGKpydTLEevigirgegqgsLKE-----FGISYRQVPLTEdgkidLEAIKKAINEKTKMVL---IqrsrgysWRPSLTI 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1816728030 160 VDI-DAIACISKAN-DCLLVVDNTFSTpFV--IKPLQHGADIVIHSLTKFFGG 208
Cdd:COG4100 178 EEIgEIIKFVKSINpDVICFVDNCYGE-FVetREPTEVGADLMAGSLIKNPGG 229
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
28-272 |
9.68e-08 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 53.50 E-value: 9.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 28 PATAYAMQDTQHYFAVSSGNGEYQYNRTANPNRDSLSAAISLMEDGEVSA----VMASGMAAISATLLSLLRQGDHLVVN 103
Cdd:cd00609 10 FPPPPEVLEALAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPeeivVTNGAQEALSLLLRALLNPGDEVLVP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 104 E---AIYGETIELIDLILVPLGVAVTYADFLSPESVQAAIRPETVMLYteIIS--NPLIKVVD---IDAIACISKANDCL 175
Cdd:cd00609 90 DptyPGYEAAARLAGAEVVPVPLDEEGGFLLDLELLEAAKTPKTKLLY--LNNpnNPTGAVLSeeeLEELAELAKKHGIL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 176 LVVDN-----TFSTPFVIKPLQHGAD---IVIHSLTKFFgGHSDLTAGSVTCS-QALMQKIELKARLLGGCSDPYTAWLC 246
Cdd:cd00609 168 IISDEayaelVYDGEPPPALALLDAYervIVLRSFSKTF-GLPGLRIGYLIAPpEELLERLKKLLPYTTSGPSTLSQAAA 246
|
250 260 270
....*....|....*....|....*....|
gi 1816728030 247 LRSIRT----MEMRVSRQMENAQRIAEALS 272
Cdd:cd00609 247 AAALDDgeehLEELRERYRRRRDALLEALK 276
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
74-297 |
2.55e-05 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 45.76 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 74 EVSAVMASGMAAISATLLSLLRQGDHLVV----NEAIYGETIEL--IDLILVPLGVAVTY-ADFlspESVQAAIRPETVM 146
Cdd:pfam00155 63 EAAVVFGSGAGANIEALIFLLANPGDAILvpapTYASYIRIARLagGEVVRYPLYDSNDFhLDF---DALEAALKEKPKV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 147 LYTEIISNPLIKVVDID---AIACISKANDCLLVVDNTFSTpFVIKPLQHGA----------DIVIHSLTKFFG--Ghsd 211
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEeleKLLDLAKEHNILLLVDEAYAG-FVFGSPDAVAtrallaegpnLLVVGSFSKAFGlaG--- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 212 LTAGSVTCSQALMQKieLKARLLGGCSDPYTAWLCLRSIRT-------MEMRVSRQMENAQRIAEALSS------DPRVA 278
Cdd:pfam00155 216 WRVGYILGNAAVISQ--LRKLARPFYSSTHLQAAAAAALSDpllvaseLEEMRQRIKERRDYLRDGLQAaglsvlPSQAG 293
|
250
....*....|....*....
gi 1816728030 279 QVNYPGLASHPQHDLAKSL 297
Cdd:pfam00155 294 FFLLTGLDPETAKELAQVL 312
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
72-179 |
4.68e-04 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 41.95 E-value: 4.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 72 DGEVsAVMASGMAAISATLLSLLRQGDHLVVNEAIYGETIELIDL-----ILVPLgVAVTYADFLSPESVQAAIRPETVM 146
Cdd:PRK07777 85 DTEV-LVTVGATEAIAAAVLGLVEPGDEVLLIEPYYDSYAAVIAMagahrVPVPL-VPDGRGFALDLDALRAAVTPRTRA 162
|
90 100 110
....*....|....*....|....*....|....*.
gi 1816728030 147 LYTEIISNPLIKVV---DIDAIACISKANDCLLVVD 179
Cdd:PRK07777 163 LIVNSPHNPTGTVLtaaELAAIAELAVEHDLLVITD 198
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
18-227 |
2.03e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 40.12 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 18 HIHPDapaifPATAYAMQDtqhyfAVSSGngeyQYNRTANPNRDS-LSAAI--SLMEDGEVSAVMASGMAAISATLLSLL 94
Cdd:PRK06225 39 HLGPH-----EEVREAMIR-----CIEEG----EYCKYPPPEGFPeLRELIlkDLGLDDDEALITAGATESLYLVMRAFL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 95 RQGDHLVVNEAIYgetiELIDLILVPLGVAVTYADF--------LSPESVQAAIRPETVMLYTEIISNPL---IKVVDID 163
Cdd:PRK06225 105 SPGDNAVTPDPGY----LIIDNFASRFGAEVIEVPIyseecnykLTPELVKENMDENTRLIYLIDPLNPLgssYTEEEIK 180
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 164 AIACISKANDCLLVVDNTFS------TPFVIKPLQHGadIVIHSLTKFFgGHSDLTAGSVTCSQALMQKI 227
Cdd:PRK06225 181 EFAEIARDNDAFLLHDCTYRdfarehTLAAEYAPEHT--VTSYSFSKIF-GMAGLRIGAVVATPDLIEVV 247
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
70-227 |
4.28e-03 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 39.14 E-value: 4.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 70 MEDGEVSAVMASGmAAISATLLSLLRQGDH---LVVNEAIYGETIELIDLILVPLGVAVTYADF-----LSPESVQAAIR 141
Cdd:cd00613 79 MDVANASLQDEAT-AAAEAAGLAAIRAYHKrnkVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSdeggtVDLEALKEEVS 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1816728030 142 PETVMLyteIISNP--LIKVVD-IDAIACISKANDCLLVVD-NTFSTPFVIKPLQHGADIVIHSLTKFF------GGHsd 211
Cdd:cd00613 158 EEVAAL---MVQYPntLGVFEDlIKEIADIAHSAGALVYVDgDNLNLTGLKPPGEYGADIVVGNLQKTGvphgggGPG-- 232
|
170
....*....|....*.
gi 1816728030 212 ltAGSVTCSQALMQKI 227
Cdd:cd00613 233 --AGFFAVKKELVRFL 246
|
|
| |
