NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1819288219|ref|WP_164992690|]
View 

MULTISPECIES: TetR/AcrR family transcriptional regulator [Streptomyces]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
17-168 2.54e-10

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 57.22  E-value: 2.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819288219  17 EQRRRRVRLEISREAARLFWAQGVDSTSGDQIAEAVGLSTRTIWRHFRSKESCAEPIIAQSVEWELATLRSWPLHRSLEE 96
Cdd:COG1309     1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1819288219  97 HFATEAKRLVGEIgtqeQADAGLGVKMMRLADTEPALRTAWLMACDQVEHELAGVIATRLGLEHDDLQVRLH 168
Cdd:COG1309    81 RLRALLRAYLEFL----AENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALAR 148
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
17-168 2.54e-10

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 57.22  E-value: 2.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819288219  17 EQRRRRVRLEISREAARLFWAQGVDSTSGDQIAEAVGLSTRTIWRHFRSKESCAEPIIAQSVEWELATLRSWPLHRSLEE 96
Cdd:COG1309     1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1819288219  97 HFATEAKRLVGEIgtqeQADAGLGVKMMRLADTEPALRTAWLMACDQVEHELAGVIATRLGLEHDDLQVRLH 168
Cdd:COG1309    81 RLRALLRAYLEFL----AENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALAR 148
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
31-71 1.46e-07

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 46.63  E-value: 1.46e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1819288219  31 AARLFWAQGVDSTSGDQIAEAVGLSTRTIWRHFRSKESCAE 71
Cdd:pfam00440   5 ARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 18-66 1.30e-03

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 38.83  E-value: 1.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1819288219  18 QRRRRVRLEISREAARLFWAQGVDSTSGDQIAEAVGLSTRTIWRHFRSK 66
Cdd:PRK10668    7 QQAQETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNK 55
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
17-168 2.54e-10

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 57.22  E-value: 2.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819288219  17 EQRRRRVRLEISREAARLFWAQGVDSTSGDQIAEAVGLSTRTIWRHFRSKESCAEPIIAQSVEWELATLRSWPLHRSLEE 96
Cdd:COG1309     1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1819288219  97 HFATEAKRLVGEIgtqeQADAGLGVKMMRLADTEPALRTAWLMACDQVEHELAGVIATRLGLEHDDLQVRLH 168
Cdd:COG1309    81 RLRALLRAYLEFL----AENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALAR 148
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
31-71 1.46e-07

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 46.63  E-value: 1.46e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1819288219  31 AARLFWAQGVDSTSGDQIAEAVGLSTRTIWRHFRSKESCAE 71
Cdd:pfam00440   5 ARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 18-66 1.30e-03

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 38.83  E-value: 1.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1819288219  18 QRRRRVRLEISREAARLFWAQGVDSTSGDQIAEAVGLSTRTIWRHFRSK 66
Cdd:PRK10668    7 QQAQETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNK 55
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 44-75 5.20e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 34.33  E-value: 5.20e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1819288219  44 SGDQIAEAVGLSTRTIWRHFRSKESCAEPIIA 75
Cdd:pfam08279  15 SGQELAEKLGVSRRTIRRDIKILEELGVPIEA 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH