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Conserved domains on  [gi|1820081185|ref|WP_165435127|]
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DHA2 family efflux MFS transporter permease subunit [Bradyrhizobium sp. Leo121]

Protein Classification

efflux MFS transporter permease( domain architecture ID 1000855)

efflux MFS (major facilitator superfamily) transporter permease, similar to Escherichia coli multidrug efflux pump EmrB and Neisseria gonorrhoeae fatty acid resistance protein FarB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
efflux_EmrB super family cl31024
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 31-519 3.64e-94

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00711:

Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 295.44  E-value: 3.64e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  31 LAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVAC 110
Cdd:TIGR00711   5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 111 AFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVV 190
Cdd:TIGR00711  85 GVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 191 PTAVMVTMLYLTLERqpMQLGLLREGDWLGIATMAIGLSALQTVLEEGNKDDWFGSPFIVKLAIVAAVSLSLFVIIELVV 270
Cdd:TIGR00711 165 IGIIVVVVAFFILPR--DKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELTD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 271 EKPLIRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARY 350
Cdd:TIGR00711 243 DNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRK 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 351 IAAVGMALFAASCFMNTqMSLNYAGDQLFV--PNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGT 428
Cdd:TIGR00711 323 LVTIGLILYAVGFYWRA-FTFTPDTPFLAIalPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 429 ALLATIATKREQFHsniigqsvdlareevRQRLAEMTNYF------MAHGMADPAAARHQAIIALGNAVKRQALVMGYSD 502
Cdd:TIGR00711 402 ALITTILTNRTQFH---------------HSQLTETINPVnpnflsGYSQLAALGNPEQQVYALIAQQITLHAFSIAINE 466

                         490
                  ....*....|....*....
gi 1820081185 503 TF--AVLGFVLVLAGIAIL 519
Cdd:TIGR00711 467 IFwmATLLFVSGLILIWFL 485
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 31-519 3.64e-94

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 295.44  E-value: 3.64e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  31 LAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVAC 110
Cdd:TIGR00711   5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 111 AFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVV 190
Cdd:TIGR00711  85 GVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 191 PTAVMVTMLYLTLERqpMQLGLLREGDWLGIATMAIGLSALQTVLEEGNKDDWFGSPFIVKLAIVAAVSLSLFVIIELVV 270
Cdd:TIGR00711 165 IGIIVVVVAFFILPR--DKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELTD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 271 EKPLIRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARY 350
Cdd:TIGR00711 243 DNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRK 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 351 IAAVGMALFAASCFMNTqMSLNYAGDQLFV--PNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGT 428
Cdd:TIGR00711 323 LVTIGLILYAVGFYWRA-FTFTPDTPFLAIalPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 429 ALLATIATKREQFHsniigqsvdlareevRQRLAEMTNYF------MAHGMADPAAARHQAIIALGNAVKRQALVMGYSD 502
Cdd:TIGR00711 402 ALITTILTNRTQFH---------------HSQLTETINPVnpnflsGYSQLAALGNPEQQVYALIAQQITLHAFSIAINE 466

                         490
                  ....*....|....*....
gi 1820081185 503 TF--AVLGFVLVLAGIAIL 519
Cdd:TIGR00711 467 IFwmATLLFVSGLILIWFL 485
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 33-521 1.28e-92

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 287.94  E-value: 1.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  33 AMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAF 112
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 113 THDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPT 192
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 193 AVMVTMLyltlerqpmqlgllregdwlgiatmaiglsalqtvleegnkddwfgspfivklaivaavslslfviielvvek 272
Cdd:cd17503   161 ILALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 273 PLIRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIA 352
Cdd:cd17503   168 PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLL 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 353 AVGMALFAASCFMNTQMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGTALLA 432
Cdd:cd17503   248 LAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 433 TIATKREQFHSNIIGQsvdlareevrqrlaemtnyfmahgmadpaaarhqaiiALGNAVKRQALVMGYSDTFAVLGFVLV 512
Cdd:cd17503   328 TLLTNRTQFHHSRLSE-------------------------------------LLAQQVQKQALIIAFNDAFLVSAILLL 370


                  ....*....
gi 1820081185 513 LAGIAILLT 521
Cdd:cd17503   371 VGLLLALFL 379
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
20-426 1.93e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 121.62  E-value: 1.93e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  20 NRASATVWISILAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGH 99
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 100 ATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENY 179
Cdd:COG2814    82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 180 GWQTIFFVNVVPTAVMVTMLYLTLERQPMQLGLLREGDWlgiatmaiglsalqtvleegnkddwfgspfivklaivaavs 259
Cdd:COG2814   162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL----------------------------------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 260 lslfviielvvekplirLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLV 339
Cdd:COG2814   201 -----------------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLA 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 340 PKLMQRFDARYIAAVGMALFAASCFMntqMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMM 419
Cdd:COG2814   264 GRLADRFGRRRLLLIGLLLLALGLLL---LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340


                  ....*..
gi 1820081185 420 RNLGGAI 426
Cdd:COG2814   341 FFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
34-428 2.47e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 92.48  E-value: 2.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  34 MIGAFMAILNIQITNASL-LNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAF 112
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 113 THDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPT 192
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 193 AVMVTMLYLTLERQPMQLGLLREGDWLGIATmaiglsalqtvleegnkddwfgspfivklaivaavslslfviielvvek 272
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIV------------------------------------------------- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 273 pliRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQlYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIA 352
Cdd:pfam07690 193 ---AWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820081185 353 AVGMALFAASCFMNTQMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGT 428
Cdd:pfam07690 269 LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK14995 PRK14995
SmvA family efflux MFS transporter;
92-437 1.58e-17

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 85.16  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  92 FRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQ-PIGLAMFSIAVTFAPAIGPT 170
Cdd:PRK14995   70 FKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQrNMALGVWAAVGSGGAAFGPL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 171 IGGYLTENYGWQTIFFVNVVPTAVMVTMLYLTLERQPMQlgllREGDW-LGIATMAIgLSALQTVLEEGNKDDWFGSPFI 249
Cdd:PRK14995  150 VGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGR----RDQPLnLGHALMLI-VAILLLVYSAKTALKGFLSLWV 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 250 VKLA-IVAAVSLSLFVIIELVVEKPLIRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLawt 328
Cdd:PRK14995  225 TSLTlLTGALLLGLFIRTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFM--- 301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 329 gLPQLILI----PLVPKLMQRFDARYIAAVGMALFAAScFMNTQMsLNYAGDQLFVPNIIRAIGQALMLAPLSAVS--LG 402
Cdd:PRK14995  302 -LPVMVASgfsgPIAGILVSRLGLRLVATGGMALSALS-FYGLAM-TDFSTQQWQAWGLMALLGFSAASALLASTSaiMA 378

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1820081185 403 SVAPQDAAAASGISNMMRNLGGAIGTALLATIATK 437
Cdd:PRK14995  379 AAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLSR 413
perm_prefix_1 NF038403
permease prefix domain 1; The permease prefix domain 1 is found as the N-terminal domain of ...
 454-491 1.04e-03

permease prefix domain 1; The permease prefix domain 1 is found as the N-terminal domain of putative permeases resembling ABC transporter permeases, and also of hypothetical proteins of unknown function. In at least some permease families, this prefix domain is only variably present, and may be replaced by a different, seemingly unrelated prefix domain.


Pssm-ID: 468503  Cd Length: 59  Bit Score: 37.49  E-value: 1.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1820081185 454 REEVRQRLAEMTNYFMAHGMaDPAAARHQAIIALGNAV 491
Cdd:NF038403   16 KEELRSHLEDKVEELIAAGL-SEEEARRAAIREFGDPD 52
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 31-519 3.64e-94

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 295.44  E-value: 3.64e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  31 LAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVAC 110
Cdd:TIGR00711   5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 111 AFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVV 190
Cdd:TIGR00711  85 GVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 191 PTAVMVTMLYLTLERqpMQLGLLREGDWLGIATMAIGLSALQTVLEEGNKDDWFGSPFIVKLAIVAAVSLSLFVIIELVV 270
Cdd:TIGR00711 165 IGIIVVVVAFFILPR--DKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELTD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 271 EKPLIRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARY 350
Cdd:TIGR00711 243 DNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRK 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 351 IAAVGMALFAASCFMNTqMSLNYAGDQLFV--PNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGT 428
Cdd:TIGR00711 323 LVTIGLILYAVGFYWRA-FTFTPDTPFLAIalPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 429 ALLATIATKREQFHsniigqsvdlareevRQRLAEMTNYF------MAHGMADPAAARHQAIIALGNAVKRQALVMGYSD 502
Cdd:TIGR00711 402 ALITTILTNRTQFH---------------HSQLTETINPVnpnflsGYSQLAALGNPEQQVYALIAQQITLHAFSIAINE 466

                         490
                  ....*....|....*....
gi 1820081185 503 TF--AVLGFVLVLAGIAIL 519
Cdd:TIGR00711 467 IFwmATLLFVSGLILIWFL 485
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 33-521 1.28e-92

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 287.94  E-value: 1.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  33 AMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAF 112
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 113 THDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPT 192
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 193 AVMVTMLyltlerqpmqlgllregdwlgiatmaiglsalqtvleegnkddwfgspfivklaivaavslslfviielvvek 272
Cdd:cd17503   161 ILALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 273 PLIRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIA 352
Cdd:cd17503   168 PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLL 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 353 AVGMALFAASCFMNTQMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGTALLA 432
Cdd:cd17503   248 LAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 433 TIATKREQFHSNIIGQsvdlareevrqrlaemtnyfmahgmadpaaarhqaiiALGNAVKRQALVMGYSDTFAVLGFVLV 512
Cdd:cd17503   328 TLLTNRTQFHHSRLSE-------------------------------------LLAQQVQKQALIIAFNDAFLVSAILLL 370


                  ....*....
gi 1820081185 513 LAGIAILLT 521
Cdd:cd17503   371 VGLLLALFL 379
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 34-436 3.16e-38

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 143.85  E-value: 3.16e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  34 MIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFT 113
Cdd:cd17321     2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 114 HDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVpta 193
Cdd:cd17321    82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP--- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 194 vmvtmlyltlerqpmqlgllregdwlgiatmaiglsalqtvleegnkddwfgspfivkLAIVAavslslfviielvvekp 273
Cdd:cd17321   159 ----------------------------------------------------------IGLVA----------------- 163

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 274 lirlrLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIAA 353
Cdd:cd17321   164 -----LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 354 VGMALFAASCFMNTQMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGTALLAT 433
Cdd:cd17321   239 AGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGA 318


                  ...
gi 1820081185 434 IAT 436
Cdd:cd17321   319 LLT 321
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
20-426 1.93e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 121.62  E-value: 1.93e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  20 NRASATVWISILAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGH 99
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 100 ATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENY 179
Cdd:COG2814    82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 180 GWQTIFFVNVVPTAVMVTMLYLTLERQPMQLGLLREGDWlgiatmaiglsalqtvleegnkddwfgspfivklaivaavs 259
Cdd:COG2814   162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL----------------------------------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 260 lslfviielvvekplirLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLV 339
Cdd:COG2814   201 -----------------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLA 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 340 PKLMQRFDARYIAAVGMALFAASCFMntqMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMM 419
Cdd:COG2814   264 GRLADRFGRRRLLLIGLLLLALGLLL---LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340


                  ....*..
gi 1820081185 420 RNLGGAI 426
Cdd:COG2814   341 FFLGGPL 347
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 34-436 1.61e-27

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 113.83  E-value: 1.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  34 MIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFT 113
Cdd:cd17504     2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 114 HDLPSMIAMRALQGFfGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFfvnvvpta 193
Cdd:cd17504    82 PNLPVLIAGRALQGI-GGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIF-------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 194 vmvtmlyltlerqpmqlgllregdwlgiatmaiglsalqtvleegnkddWFGSPFIVKLAIVAavslslfviielvvekP 273
Cdd:cd17504   153 -------------------------------------------------WTAAPVAVLLAALV----------------P 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 274 LIRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLY----NAEQIGQVLAWTGLPQLILIPLVPKLMQRFDAR 349
Cdd:cd17504   168 LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTgfglGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 350 YIAAVGMALFAASCFMntQMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGTA 429
Cdd:cd17504   248 RVLLIGLVISAVGLLL--LALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPA 325


                  ....*..
gi 1820081185 430 LLATIAT 436
Cdd:cd17504   326 IAGAILT 332
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 32-438 1.18e-23

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 104.25  E-value: 1.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  32 AAMIGAFMAILNIQITNASLL-NIEGGIGtGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVAC 110
Cdd:cd06179     1 AALCLAYFAQLFGVTLPAAVLpFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 111 AFTHDLPSMIAMRALQGfFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENY--GWQTIFFVN 188
Cdd:cd06179    80 GTAKSVNMLIGGQALIG-IGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYIN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 189 VVPTAVMVTMLYL-------TLERQPMQLGLLREGDWLGIATMAIGLSALQTVLEEGNKDDWFGSPFIVKLAIVAAVSLS 261
Cdd:cd06179   159 AIFNALALILLFFfyhppprPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLLI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 262 LFVIIELVVEK--PLIRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLV 339
Cdd:cd06179   239 AFGLYEWKGTKdgLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 340 PKLMQRF-DARYIAAVGMALFAASC-FMNTQMSLNYAgdQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISN 417
Cdd:cd06179   319 GLLLTKIkHIKWQLVAGFVLFTAFLaLLALITPDNKA--LAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLG 396

                         410       420
                  ....*....|....*....|.
gi 1820081185 418 MMRNLGGAIGTALLATIATKR 438
Cdd:cd06179   397 SARALGGAVGTAIFTSILSNR 417
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 34-430 1.21e-23

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 101.87  E-value: 1.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  34 MIGAFMAILNIQITNASLLNIEGGIGtGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFT 113
Cdd:cd17502     2 MLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 114 HDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVvpta 193
Cdd:cd17502    81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINL---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 194 vmvtmlyltlerqpmqlgllregdwlgiatmaiglsalqtvleegnkddwfgsPFIVklaivaavsLSLFVIielvvekp 273
Cdd:cd17502   157 -----------------------------------------------------PIGG---------LALALL-------- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 274 lirlrllaqRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFD-ARYIA 352
Cdd:cd17502   167 ---------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLI 237

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820081185 353 AVGMALFAASCFMNTQMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGTAL 430
Cdd:cd17502   238 VIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 19-306 2.08e-21

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 94.49  E-value: 2.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  19 PNRASATVWISILAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIG 98
Cdd:COG0477     5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  99 HATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTEN 178
Cdd:COG0477    85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 179 YGWQTIFFVNVVPTAVMVTMLYLTLE--RQPMQLGLLREGDWLGIATMAIGLSALQTVLEEGNKDDWFGSPFIVKLAIVA 256
Cdd:COG0477   165 LGWRWIFLINAPLGLLALVLRLRLPEsrGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLA 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1820081185 257 AVSLSLFVIIELVVEKPLIRLRLLAQRSFGFGTISAVFVGFALFGSVYLL 306
Cdd:COG0477   245 LLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
MFS_1 pfam07690
Major Facilitator Superfamily;
34-428 2.47e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 92.48  E-value: 2.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  34 MIGAFMAILNIQITNASL-LNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAF 112
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 113 THDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPT 192
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 193 AVMVTMLYLTLERQPMQLGLLREGDWLGIATmaiglsalqtvleegnkddwfgspfivklaivaavslslfviielvvek 272
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIV------------------------------------------------- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 273 pliRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQlYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIA 352
Cdd:pfam07690 193 ---AWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820081185 353 AVGMALFAASCFMNTQMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGT 428
Cdd:pfam07690 269 LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 66-427 4.00e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 86.09  E-value: 4.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  66 SWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKL 145
Cdd:cd17325    34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 146 PKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVptavmvtmlyltlerqpmqlgllregdwLGIATMA 225
Cdd:cd17325   114 PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA----------------------------LALLALV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 226 IGLSALQTVLEEGNKDDWFGSPFivklaivaavslslfviielvvekpLIRLRLLAQRSFGFGTISAVFVGFALFGSVY- 304
Cdd:cd17325   166 LALLLLPEPRPPPNKRAVSAARL-------------------------RSGLRLLLRDRRLLALFLAIFVLAFAFGALEp 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 305 LLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIAAVGMALFAASCFMntqMSLNYAGDQLFVPNII 384
Cdd:cd17325   221 FLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL---LPLATSFWLLLLLLAL 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1820081185 385 RAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIG 427
Cdd:cd17325   298 LGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
PRK14995 PRK14995
SmvA family efflux MFS transporter;
92-437 1.58e-17

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 85.16  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  92 FRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQ-PIGLAMFSIAVTFAPAIGPT 170
Cdd:PRK14995   70 FKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQrNMALGVWAAVGSGGAAFGPL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 171 IGGYLTENYGWQTIFFVNVVPTAVMVTMLYLTLERQPMQlgllREGDW-LGIATMAIgLSALQTVLEEGNKDDWFGSPFI 249
Cdd:PRK14995  150 VGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGR----RDQPLnLGHALMLI-VAILLLVYSAKTALKGFLSLWV 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 250 VKLA-IVAAVSLSLFVIIELVVEKPLIRLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLawt 328
Cdd:PRK14995  225 TSLTlLTGALLLGLFIRTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFM--- 301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 329 gLPQLILI----PLVPKLMQRFDARYIAAVGMALFAAScFMNTQMsLNYAGDQLFVPNIIRAIGQALMLAPLSAVS--LG 402
Cdd:PRK14995  302 -LPVMVASgfsgPIAGILVSRLGLRLVATGGMALSALS-FYGLAM-TDFSTQQWQAWGLMALLGFSAASALLASTSaiMA 378

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1820081185 403 SVAPQDAAAASGISNMMRNLGGAIGTALLATIATK 437
Cdd:PRK14995  379 AAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLSR 413
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 37-427 8.67e-16

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 79.15  E-value: 8.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  37 AFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDL 116
Cdd:cd17474     8 TLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 117 PSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTEnYGWQTIFfvnvvptavmv 196
Cdd:cd17474    88 ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPF----------- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 197 tmlyltlerqpmqlgllregdWLGIATMAIGLSALQTVLEEGNKDDWFGSPFIVKLAIVAAVSLSLFVIIelvvekplir 276
Cdd:cd17474   156 ---------------------FLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFL---------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 277 lrllaqrsfgfgtISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLA-WTGLPQLILIPLVPKLMQRFDARYIAAVG 355
Cdd:cd17474   205 -------------VSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAgWSVLLALGSLFVGRLLKKRFGARRILVIG 271

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820081185 356 MALFAASCFMntqMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIG 427
Cdd:cd17474   272 LLLYALSLLL---LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 72-432 2.95e-15

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 77.62  E-value: 2.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  72 YLIGEIVVIPLTDYLSRvfsfRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQP 151
Cdd:cd17320    47 FALGQLLYGPLSDRFGR----RPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 152 IGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVnvvptavmvtmlyltlerqpmqlgllregdWLGIATMAIGLSAL 231
Cdd:cd17320   123 KIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF------------------------------LALLGLLLLLLVLL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 232 QtvLEEGNKDDWFGSPFIVKLAIVAavslslfviielvvekplirlRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLG 311
Cdd:cd17320   173 F--LPETLPEEKRKPLLSSLLRAYK---------------------RVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYI 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 312 QVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIAAVGMALFAASCFMNTQMSLNYAGDQ--LFVPNIIRAIGQ 389
Cdd:cd17320   230 EQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLwpLVAPLFLIFFGF 309

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1820081185 390 ALMLAPLSAVSLgSVAPQDAAAASGISNMMRNLGGAIGTALLA 432
Cdd:cd17320   310 GLIFPNATSLAL-EPFPHVAGTASALLGFLQFLIGALAGALVG 351
PRK10504 PRK10504
putative transporter; Provisional
 36-288 1.51e-13

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 72.84  E-value: 1.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  36 GAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHD 115
Cdd:PRK10504   18 GFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGT 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 116 LPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNV---VPT 192
Cdd:PRK10504   98 LNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIpvgIIG 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 193 AVMVTMLYLTLERQPmqlgllREGDWLGIATMAIGLSALQTVLeEGNKDDWFGSPFIVKLAIVAAVSLSLFVIIELVVEK 272
Cdd:PRK10504  178 AIATLMLMPNYTMQT------RRFDLSGFLLLAVGMATLTLAL-DGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNR 250

                         250
                  ....*....|....*.
gi 1820081185 273 PLIRLRLLAQRSFGFG 288
Cdd:PRK10504  251 ALFSLKLFRTRTFSLG 266
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
27-436 2.31e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 71.44  E-value: 2.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  27 WISILAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIF 106
Cdd:COG2271     9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 107 SVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFF 186
Cdd:COG2271    89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 187 VNVVPTAVMVtmlyltlerqpmqlgllregdwlgiatmaiglsalqtvleegnkddwfgspfivklaivaavslslfvii 266
Cdd:COG2271   169 ILGLPGLLLA---------------------------------------------------------------------- 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 267 elvvekpLIRLRLLAqrsfgfgtISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRF 346
Cdd:COG2271   179 -------LLRFWLLA--------LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 347 DARY--IAAVGMALFAASCFMNTQMSLNYAgdqLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGG 424
Cdd:COG2271   244 GRRRklVLAIGLLLAALALLLLALLPSPAL---AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG 320

                         410
                  ....*....|..
gi 1820081185 425 AIGTALLATIAT 436
Cdd:COG2271   321 ALGPLLVGYLLD 332
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 35-435 1.11e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 69.76  E-value: 1.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  35 IGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTH 114
Cdd:cd06174     3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 115 DLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTEN--YGWQTIFFVNVVPT 192
Cdd:cd06174    83 SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 193 AVMVTMLYLTLERQPmqlgllregdwlgiatmaiglsalqtvLEEGNKDDWFGSPFIVKLAivaavslslfviielvvek 272
Cdd:cd06174   163 LLAAILLLLVVPDPP---------------------------ESARAKNEEASSKSVLKLL------------------- 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 273 plirLRLLAQRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIA 352
Cdd:cd06174   197 ----KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 353 AVGMALFAASCFMNtqMSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGTALLA 432
Cdd:cd06174   273 LLIGLLLMALGLAL--LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG 350


                  ...
gi 1820081185 433 TIA 435
Cdd:cd06174   351 FLL 353
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 30-430 1.54e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 69.12  E-value: 1.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  30 ILAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVA 109
Cdd:cd17324     1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 110 CAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNV 189
Cdd:cd17324    81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 190 VPTAVMVTMLYLTLERQPMQlgllregdwlgiatmaiglsalqtvleegnkddwfgspfivklaivAAVSLSLFVIIELV 269
Cdd:cd17324   161 VLALLAALLLWRLLPSLPPK----------------------------------------------KPGSLGLLSSLLLL 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 270 VEKPLIRLRLLAqrsfgfgtisAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFdAR 349
Cdd:cd17324   195 LRNPRLRLAYLI----------TFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG-GR 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 350 YIAAVGMALFAASCFMNTQMSLNYAGdqLFVPNIIRAIGQALMLAPLSAVsLGSVAPQDAAAASGISNMMRNLGGAIGTA 429
Cdd:cd17324   264 RALLIALLLLAAALLLLTLLGPSPLL--LLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGGALGAA 340


                  .
gi 1820081185 430 L 430
Cdd:cd17324   341 L 341
2_A_01_02 TIGR00880
Multidrug resistance protein;
70-201 2.08e-12

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 64.59  E-value: 2.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  70 TSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQ 149
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1820081185 150 QPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVN-VVPTAVMVTMLYL 201
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLaILALAAFILLAFL 137
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 86-203 2.28e-12

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 68.76  E-value: 2.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  86 LSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGG-VLIPMAFTL--VFTKlpkAQQPIGLAMFSIAVT 162
Cdd:cd17323    57 LSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSsPLAIGAGTIadLFTP---EERGKAMGVYSLGPL 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1820081185 163 FAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYLTL 203
Cdd:cd17323   134 LGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFL 174
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 14-203 8.45e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 60.83  E-value: 8.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  14 RAAVDPNRASATVWISILAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFR 93
Cdd:TIGR00895   3 QNNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  94 NIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGG 173
Cdd:TIGR00895  83 RVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAG 162

                         170       180       190
                  ....*....|....*....|....*....|
gi 1820081185 174 YLTENYGWQTIFFVNVVPTAVMVTMLYLTL 203
Cdd:TIGR00895 163 WLIPVFGWRSLFYVGGIAPLLLLLLLMRFL 192
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 24-203 1.64e-09

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 59.70  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  24 ATVWISILAAMIGAfmaiLNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLF 103
Cdd:TIGR00710   5 AFALLLGCLSILGP----LGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 104 AIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQT 183
Cdd:TIGR00710  81 ALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHA 160

                         170       180
                  ....*....|....*....|
gi 1820081185 184 IFFVNVVPTAVMVTMLYLTL 203
Cdd:TIGR00710 161 IFAFLSLAGILLSALIFFIL 180
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 66-436 6.69e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 57.97  E-value: 6.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  66 SWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLV--FT 143
Cdd:cd17473    38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIgdYF 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 144 KLPKAQQPIGLAmfSIAVTFAPAIGPTIGGYLTEnYGWQTIFFVNVVPTAVMVTMLYLTLERQPmqlgllregdwlgiat 223
Cdd:cd17473   118 EGEERAKMLGLQ--SAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPAR---------------- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 224 maiglsalqtvleegnkddwfGSPFIVKLAIVAAVSLSLFVIIELVVekplirlrllaqrsfgfgtisAVFVGFALFGSV 303
Cdd:cd17473   179 ---------------------KSKSAASPGAATAAALPWKRVLPIYF---------------------LAFLAMLLFYVI 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 304 YL-LPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIAAVGMALFAASCFMNTQMSLNYAgdqLFVPN 382
Cdd:cd17473   217 PIqLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWV---VLLGA 293

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1820081185 383 IIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGTALLATIAT 436
Cdd:cd17473   294 ILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVN 347
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
74-211 7.68e-09

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 57.62  E-value: 7.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  74 IGEIVVIPLTDYLSRvfsfRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFG---GVLIPMAFTLVFTKLPKAQQ 150
Cdd:PRK11102   41 IGQLFYGPMADSFGR----KPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAaaaSVVINALMRDMFPKEEFSRM 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820081185 151 pigLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYL----TL---ERQPMQLG 211
Cdd:PRK11102  117 ---MSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFfipeTLpkeRRQPFHLR 181
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 68-435 4.94e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 54.91  E-value: 4.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  68 ISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPK 147
Cdd:cd17489    36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 148 AQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYLTLERQPmqlgllregdwlgiatmaig 227
Cdd:cd17489   116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPP-------------------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 228 lsalqTVLEEGNKDDWFGSPFIVKLAIVAAVSLSLFviielvvekplirlrllaqrSFGFGTISAvfvgfalfgsvyLLP 307
Cdd:cd17489   176 -----VAAEEAEAGTRAFRRLVEKKVLPPALILFLA--------------------SIAYGAIST------------FLP 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 308 AYLGQVqlyNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIAAVGMALFAASCFMNTQMSLNYAgdqLFVPNIIRAI 387
Cdd:cd17489   219 LYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWM---LLLAAVLYGL 292

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1820081185 388 GQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGTALLATIA 435
Cdd:cd17489   293 GFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 27-430 7.84e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 54.50  E-value: 7.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  27 WISILAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIF 106
Cdd:cd17319     2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 107 SVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFF 186
Cdd:cd17319    82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 187 VNVVPTAVMVTMLYLTLerqpmqlgllregdwlgiatmaiglsalqtvleegnkddwfgspfivklaivaavslslfvii 266
Cdd:cd17319   162 IEGLLGLLLAVLWWFYL--------------------------------------------------------------- 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 267 elvvekplirlrllaqRSFGFGTISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRF 346
Cdd:cd17319   179 ----------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 347 D---ARYIAAVGMALFAAScfmntqMSLNYAGDQLFVPNIIRAIGQALMLA---PLSAVSLGSVAPQDAAAASGISNMMR 420
Cdd:cd17319   243 LrgaRRLVIIIGLLLAAVG------LLLAYLTTSPVVAVILLSLAGFGIGAaspVFWSLPADLLPGEAAATAGGLINSGG 316

                         410
                  ....*....|
gi 1820081185 421 NLGGAIGTAL 430
Cdd:cd17319   317 NLGGFVAPLL 326
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 45-207 1.68e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 53.39  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  45 QITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRA 124
Cdd:cd17328    16 FTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 125 LQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTE-NYGWQTIFFVNVVPTAVMVTMLYLTL 203
Cdd:cd17328    96 LVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLGVLLAILLLLFV 175


                  ....
gi 1820081185 204 ERQP 207
Cdd:cd17328   176 REPP 179
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 93-187 1.47e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 50.34  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  93 RNIMIGHATL-FAIFSVACAFTHDLPSMIAMRALQGFFGGvLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTI 171
Cdd:cd17391    65 RKPMLLRASLgMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLL 143

                          90
                  ....*....|....*.
gi 1820081185 172 GGYLTENYGWQTIFFV 187
Cdd:cd17391   144 GGFLADLFGIRNVFFI 159
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 73-203 1.64e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 50.28  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  73 LIGEIVVIPLTDYLSRvfsfRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPI 152
Cdd:cd17365    48 AIGALLAGPLADRFGR----KRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSL 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1820081185 153 GLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYLTL 203
Cdd:cd17365   124 AVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL 174
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 33-205 2.89e-06

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 49.57  E-value: 2.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  33 AMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAF 112
Cdd:cd17476     3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 113 THDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPK-AQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVP 191
Cdd:cd17476    83 SPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAIL 162

                         170
                  ....*....|....
gi 1820081185 192 TAVMVTMLYLTLER 205
Cdd:cd17476   163 AAIVAVAAIFWTSP 176
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
216-434 4.92e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.13  E-value: 4.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 216 GDWLGIATMAIGLSALQTVLEEGNKDDWFGSPFIVKLAIVAAVSLSLFVIIELVV-EKPLIRLR-----LLAQRSFGFGT 289
Cdd:COG2211   155 FAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVpEEEKVSLKeslkaLLKNRPFLLLL 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 290 ISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIAAVGMALFAASCFMntqM 369
Cdd:COG2211   235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL---L 311

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820081185 370 SLNYAGD--QLFVPNIIRAIGQALMLAPLSAVsLGSVAPQD--------AAAASGISNMMRNLGGAIGTALLATI 434
Cdd:COG2211   312 FFLGPGNlwLLLVLAALAGIGLGAILVLPWAM-LADVVDYDewktgrrrEGLYFGIFTFAIKLGQALAGALAGLL 385
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
27-434 1.27e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.57  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  27 WISILAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIF 106
Cdd:COG2223     4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 107 SVACAFTHDLPSMIAMRALQGFFGGVL--IPMAFTLVFTklPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTI 184
Cdd:COG2223    84 LLLLALAVSYWLLLLLGLLLGIGGGGSfaVGIALVSKWF--PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 185 FFVNVVPTAVMVTMLYLTLERQPMQLGLLREGDWLGIATMAiglsalqtvleeGNKDDWFGspfivklaivaavslslfv 264
Cdd:COG2223   162 FLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAL------------RDPRFWLL------------------- 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 265 iielvvekplirlrllaqrSFGFGTISAVFVGFALFgsvylLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQ 344
Cdd:COG2223   211 -------------------SLLYFGTFGSFIGFSSW-----LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 345 RFDARYIAAVGMALFAASCFMNTQMSLNYAGdqLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGG 424
Cdd:COG2223   267 RIGGRRVLLIVFALMALGLLLLALALGSLWL--FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGG 344

                         410
                  ....*....|
gi 1820081185 425 AIGTALLATI 434
Cdd:COG2223   345 FLGPLLFGAL 354
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 86-202 1.33e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.57  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  86 LSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAP 165
Cdd:cd17474   258 LKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQ 337

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1820081185 166 AIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYLT 202
Cdd:cd17474   338 AVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 66-203 4.04e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.03  E-value: 4.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  66 SWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVlIPMAFTLVFTKL 145
Cdd:cd17330    37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADIT 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1820081185 146 PKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYLTL 203
Cdd:cd17330   116 DEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL 173
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 44-275 4.90e-05

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 46.20  E-value: 4.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  44 IQITNASLLNIEGGIGTGvDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMR 123
Cdd:pfam06609  60 LQASASALPNILQDIGQS-ENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAM 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 124 ALQGFFGGvliPMAFTLVFTK--LPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYL 201
Cdd:pfam06609 139 TLLGVAAG---PAGASPLFIGelMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIII 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 202 TLE---------RQPMQLGLLREGDWLGIATMAIGLSA-LQTVLEEGNKDDWFGSPFIVKLAIVAAVSLSLFVIIELV-- 269
Cdd:pfam06609 216 WYHppsfaqlhgKKARKRDELAKLDWIGIFLVIAGTSLfLLGVSWGGKPNNPWNSAKIIGLISSGAGSLVIFALYEVFgk 295


                  ....*.
gi 1820081185 270 VEKPLI 275
Cdd:pfam06609 296 PEQPII 301
emrD PRK11652
multidrug transporter EmrD;
71-209 8.65e-05

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 44.90  E-value: 8.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  71 SYLIGEIVVIPLTDYLSRvfsfRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTL-----VFTKL 145
Cdd:PRK11652   55 TYGLSQLFYGPLSDRVGR----RPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLprdlyEGTQL 130

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820081185 146 PKAQqpiglAMFSIAVTFAPAIGPTIGGYLTENYGWQTIF-FVNVVPTAVMVTMLYLTLERQPMQ 209
Cdd:PRK11652  131 RHAN-----SLLNMGILVSPLLAPLIGGLLTTLFGWRACYlFLLLLGAGVTFSMARWMPETRPAD 190
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
93-208 9.38e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 44.91  E-value: 9.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  93 RNIMIGHATL-FAIFSVACAFTHDLPSMIAMRALQGFFGGvLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTI 171
Cdd:PRK09874   83 RKIMLLRSALgMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLA 161

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1820081185 172 GGYLTENYGWQTIFFV--NVVPTAVMVTMLYLTLERQPM 208
Cdd:PRK09874  162 GGLLADSYGLRPVFFItaSVLFLCFLVTLFCIRENFQPV 200
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 74-430 1.14e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.53  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  74 IGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIG 153
Cdd:cd17329    46 VAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRA 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 154 LAMFSIAVTFAPAIGPTIGGYLTEnYGWQTIFFVNVVPTAVMVTMLYLTLERqpmqlgllregdwlgiaTMAIGLSALQT 233
Cdd:cd17329   126 FSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPE-----------------TRPKRRAAEKT 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 234 VLEEGNKddwfgspfivklaivaavslslfviielvvekplirlRLLAQRSFgFGTISAVFVGFALFGSVYL-LPAYLGQ 312
Cdd:cd17329   188 EILRGYK-------------------------------------IVLRDRAF-LLFLLASFLISLIYFQLEStLPVYVVE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 313 VQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIAAVGMALFAASCFMnTQMSLNYAGdqLFVPNIIRAIGQaLM 392
Cdd:cd17329   230 ILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAV-LAFANTLAV--LILAMIVLTLGE-ML 305

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1820081185 393 LAPLSAVSLGSVAPQDAAAAS-GISNMMRNLGGAIGTAL 430
Cdd:cd17329   306 VFPAVQTLVAALAPPDKRGSYmGFYALAWGLGRAIGPLV 344
MFS_1 pfam07690
Major Facilitator Superfamily;
290-436 1.80e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 290 ISAVFVGFALFGSVYLLPAYLGQVQLYNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIAAVGMALFAASCFMntqM 369
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL---L 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820081185 370 SLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGTALLATIAT 436
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS 146
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
59-205 1.85e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.71  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  59 GTGVDNGSWISTSYLIGEIVVIPLTDYLSRVF--SFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPM 136
Cdd:COG2271   212 GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGL 291

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1820081185 137 AFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYLTLER 205
Cdd:COG2271   292 LWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 66-205 2.30e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 43.34  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  66 SWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLV--FT 143
Cdd:cd17317    28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGmeIV 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820081185 144 kLPKAQQPIGLA---MFSIAVTFAPAIgptigGYLTENygWQTIFFVNVVPTAVMVTMLYLTLER 205
Cdd:cd17317   108 -GPKYRSFVGILfglFWALGYMLLALL-----AYLIRD--WRWLQLAISLPGLLFLLLLWWLPRR 164
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 26-187 2.78e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 43.39  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  26 VWISILAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAI 105
Cdd:cd17327     4 LFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 106 FSVACAFTHDLPSMIAMRALQGFFGGVLIPmAFTLVFTKL-PKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTEN------ 178
Cdd:cd17327    84 LTLLTAAVKNFGGLIALRFFLGLFESGVFP-GFILYLGMWyKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvggl 162


                  ....*....
gi 1820081185 179 YGWQTIFFV 187
Cdd:cd17327   163 AGWRWLFII 171
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 26-201 2.80e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 43.37  E-value: 2.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  26 VWISILAAMIGAFMAILNIQITNASLLNIEGGIGTGvdngSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAI 105
Cdd:cd06173   211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGY----GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 106 FSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIF 185
Cdd:cd06173   287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366

                         170
                  ....*....|....*.
gi 1820081185 186 FVNVVPTAVMVTMLYL 201
Cdd:cd06173   367 LLAGALLLLAALLLLL 382
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 26-201 2.86e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 43.08  E-value: 2.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  26 VWISILA-AMIGAFMAILNIQITNASllnieggiGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFA 104
Cdd:cd17333     1 LYISFFSnGLTDALLGILGPSLEEAF--------NLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLIS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 105 IFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKaQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTI 184
Cdd:cd17333    73 LALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEE-SSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSW 151

                         170
                  ....*....|....*..
gi 1820081185 185 FFVNVVPTAVMVTMLYL 201
Cdd:cd17333   152 AYLIIGLIYLLLAILIL 168
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 66-187 2.93e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 43.38  E-value: 2.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  66 SWISTSYLIGEIVVIPLTDYLSRVFSFRnIMIGHATLFAifSVACAFT-----HDLPSMIAMRALQGFFGGVLIPMAFTL 140
Cdd:cd17318    59 GIILSSFFYGYILTQIPGGYLAEKYGAK-RVLGYSILIT--ALLTLLTplaarGGYGALIVLRILQGLAQGVTFPAMHAL 135

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1820081185 141 VFTKLPKAQQPiglAMFSIAVT---FAPAIGPTIGGYLTENYGWQTIFFV 187
Cdd:cd17318   136 WAKWAPPLERS---RLTSIAYSgsqFGTVIAMPLSGFLCESLGWPSIFYI 182
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
82-196 3.52e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  82 LTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGlAMFSIAV 161
Cdd:COG0738   265 LGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAV-SAVLIMG 343

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1820081185 162 TFAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMV 196
Cdd:COG0738   344 IVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLIL 378
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 71-203 4.59e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.59  E-value: 4.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  71 SYLIGEIVVIPLTDYLSRVFSFRNIMIghatLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQ 150
Cdd:cd17316    48 GRPIGALLFGYLGDRIGRKKALILTLL----LFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRR 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1820081185 151 ----PIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYLTL 203
Cdd:cd17316   124 gfalGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRRRTL 180
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 66-201 4.63e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.56  E-value: 4.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  66 SWISTSYLIGEIVVIPLTDYLSRVfsfRNIMIGhATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKL 145
Cdd:cd17325   242 GAQGLASALSQPPAGKLSDRIGRK---PLILIG-LLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1820081185 146 PKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYL 201
Cdd:cd17325   318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
perm_prefix_1 NF038403
permease prefix domain 1; The permease prefix domain 1 is found as the N-terminal domain of ...
 454-491 1.04e-03

permease prefix domain 1; The permease prefix domain 1 is found as the N-terminal domain of putative permeases resembling ABC transporter permeases, and also of hypothetical proteins of unknown function. In at least some permease families, this prefix domain is only variably present, and may be replaced by a different, seemingly unrelated prefix domain.


Pssm-ID: 468503  Cd Length: 59  Bit Score: 37.49  E-value: 1.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1820081185 454 REEVRQRLAEMTNYFMAHGMaDPAAARHQAIIALGNAV 491
Cdd:NF038403   16 KEELRSHLEDKVEELIAAGL-SEEEARRAAIREFGDPD 52
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 289-430 1.70e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.87  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 289 TISAVFVGFALFGSVYLLPAYLGQVQLyNAEQIGQVLAWTGLPQLILIPLVPKLMQRFDARYIAAVGMALFAASCFMntq 368
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQSFGL-SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL--- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820081185 369 MSLNYAGDQLFVPNIIRAIGQALMLAPLSAVSLGSVAPQDAAAASGISNMMRNLGGAIGTAL 430
Cdd:cd06174    78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLL 139
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 93-209 2.53e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 40.33  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  93 RNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIG 172
Cdd:PRK11551   80 KRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIG 159

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1820081185 173 GYLTENYGWQTIFFV-NVVPTAVM-VTMLYLTLERQPMQ 209
Cdd:PRK11551  160 VLAAGDAAWRHIFYVgGVGPLLLVpLLMRWLPESRAFAQ 198
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 66-188 3.06e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.90  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  66 SWISTSYLIGEIVVIPL-TDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTK 144
Cdd:cd17490   233 GLLSIIYLLPNALASLLsGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEG 312

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1820081185 145 LPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVN 188
Cdd:cd17490   313 VPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVI 356
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 103-187 3.31e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 39.85  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 103 FAIFSVACAFT-----HDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQP----IGLAMFSIAVTFAPAIGPtigg 173
Cdd:cd17380    71 VALWSLATLLTpllaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSravsIVTAGSYLGTLLGGLIGP---- 146

                          90
                  ....*....|....
gi 1820081185 174 YLTENYGWQTIFFV 187
Cdd:cd17380   147 LLLEYYGWPSVFYF 160
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 27-200 3.84e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 39.72  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  27 WISILAAMIGAFMAILNIQITNASLLNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIF 106
Cdd:cd06174   204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALG 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 107 SVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLT-ENYGWQTIF 185
Cdd:cd06174   284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAF 363

                         170
                  ....*....|....*
gi 1820081185 186 FVNVVPTAVMVTMLY 200
Cdd:cd06174   364 LVLAVLLLLAAILLL 378
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 67-207 3.92e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 39.56  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  67 WISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFTKLP 146
Cdd:cd17312    42 IIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFS 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820081185 147 KAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTMLYLTLERQP 207
Cdd:cd17312   122 KKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 6-199 4.10e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 4.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185   6 LSATAPLPRAAVDPNRASATVWISILAAMIGAFMAILnIQITNASLLNIEG-GIGTGVDNGSWISTSYLIGEIVVIPLTD 84
Cdd:cd17477   166 LLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGF-LEGAFYSLLPLYGlRLGLSVAQAALLLAAFVLGGLLLQWPLG 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  85 YLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMI-AMRALQGFFGGVLIPMAFTLVFTKLPKAQQPIGLAMFSIAVTF 163
Cdd:cd17477   245 WLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALlVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGL 324

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1820081185 164 APAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTML 199
Cdd:cd17477   325 GSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 65-435 5.31e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 39.28  E-value: 5.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  65 GSWISTSYLIGEIVVIPLTD-YLSRVFSFRNIMighatLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTLVFT 143
Cdd:TIGR00881  36 LSSFSIAYGISKFVMGSVSDrSNPRVFLPIGLI-----LCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 144 KLPKAQQPIGLAMFSIAVTFAPAIGPTIGGY-LTENYGWQTIFFVNVVpTAVMVTMLYLTLERQPMQlgllregdwlgia 222
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGI-IAIIVSLICFLLLRDSPQ------------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 223 tmAIGLSALqtvleegnkDDWFGSPFIVKLAIVAAVSLSLFVIIELVVEKPLIRLRLLAQrsfgfgtisaVFVGFALFGS 302
Cdd:TIGR00881 177 --SCGLPPA---------EEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGY----------VFVYVVRTGI 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 303 VYLLPAYLGQVQLYNAEQIGQ---VLAWTGLPQLILIPLVPKLM---QRFDARYIAAVGMALFAASCFMNtqMSLNYAGD 376
Cdd:TIGR00881 236 LDWSPLYLTQEKGFSKEKASWaftLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVSLLVYWLN--PAANPLMD 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1820081185 377 QLFVPNIIRAIGQALMLAPLSAVSLgsVAPQDAAAASGISNMMRNLGGAIGTALLATIA 435
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLIGVIASEL--APKKAAGTAAGFVGFFAYLGGILAGLPLGYLA 370
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 61-201 5.60e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.11  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  61 GVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFTL 140
Cdd:cd17489   225 GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQAL 304

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820081185 141 VFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENYGWQTIFFVN-VVPTAVMVTMLYL 201
Cdd:cd17489   305 AVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAaVVVLLALVLYIFL 366
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 22-193 5.60e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.10  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  22 ASATVWISILAAMIGAFMAILNIQITNASL-LNIEGGIGTGVDNGSWISTSYLIGEIVVIPLTDYLSRVFSFRNIMIGHA 100
Cdd:cd17504   175 RRRNVLLANITALLAGFGMFMVFQLLPQLLqLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGL 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185 101 TLFAIFSVACAFTHDLPSMIAMRALQGFFGGVLIPMAFT-LVFTKLPKAQQPIGLAMFSIAVTFAPAIGPTIGGYLTENY 179
Cdd:cd17504   255 VISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPnIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTY 334

                         170
                  ....*....|....
gi 1820081185 180 gwQTIFFVNVVPTA 193
Cdd:cd17504   335 --TVSITSGGVPTE 346
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
74-198 5.63e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 39.11  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  74 IGEIVVIPLTDYLSRvfsfRNIMIGHATLFAIFSVACAFTHDLPSMIAMRALQGFfgGV----LIPMAftLVFTKLP--K 147
Cdd:PRK11043   56 LGQLLWGPLSDRYGR----KPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAV--GVcsaaVIWQA--LVIDRYPaqK 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1820081185 148 AQQPIGLAMFSIAVTfaPAIGPTIGGYLTENYGWQTIFFVNVVPTAVMVTM 198
Cdd:PRK11043  128 ANRVFATIMPLVALS--PALAPLLGAWLLNHFGWQAIFATLFAITLLLILP 176
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 26-175 8.73e-03

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 38.77  E-value: 8.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  26 VWISILAAMIGAF-MAILNIQITNasllnIEGGIG-----TGVdngswISTSYLIGE-IVVIPLTDYLSRVFSFRNIMIG 98
Cdd:cd17403     6 FFLCIFAFLQGMVvNGFVNVSITT-----IEKRFGltstqTGL-----IASSYDIASvLLLLFVSYFGGRGHKPRWLGIG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820081185  99 hATLFAIFSVACAFTHDLPSMIAMrALQGFfGGVliPMaFTLVFTKL----PKAQQPIGLAMFSIAVTFAPAIGPTIGGY 174
Cdd:cd17403    76 -AFIMGIGSLVFALPHFTVFILAQ-LLHGA-GAT--PL-YTLGVTYLdenvSTKMSPLYIGIFYAMAILGPAIGYVLGGF 149


                  .
gi 1820081185 175 L 175
Cdd:cd17403   150 L 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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