|
Name |
Accession |
Description |
Interval |
E-value |
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
21-512 |
2.22e-107 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 328.95 E-value: 2.22e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 21 IFAFASMCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLM 100
Cdd:TIGR00711 1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 101 SLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFF 180
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 181 INVVPGIYIAVAVPLLVKVDSadPTLLRGADYLSILLLALSLGCLEYTLEEGPRWGWFDDATLTTTAWVALLCGVAFVIR 260
Cdd:TIGR00711 161 INVPIGIIVVVVAFFILPRDK--PAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 261 TLRHPQPVMDLRALQDRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRV 340
Cdd:TIGR00711 239 ELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 341 DLRWLLMAGLIGFAVSMYSFVP-ITHDWGADQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGA 419
Cdd:TIGR00711 319 DPRKLVTIGLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGS 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 420 IGIALCGTVLNDRTNLHYSRLADHLNNANLAMSDFVQRSAANftvqgispDAAQTAALKNLSALALREARTQAFSDAFYL 499
Cdd:TIGR00711 399 IGTALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAAL--------GNPEQQVYALIAQQITLHAFSIAINEIFWM 470
|
490
....*....|...
gi 1820388781 500 IMMGFLLAALLVP 512
Cdd:TIGR00711 471 ATLLFVSGLILIW 483
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
27-446 |
1.96e-98 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 302.19 E-value: 1.96e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 27 MCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGW 106
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 107 AWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPG 186
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 187 IYIAVAVPLLvkvdsadptllrgadylsilllalslgcleytleegprwgwfddatltttawvallcgvafvirtlrhpq 266
Cdd:cd17503 161 ILALLLAPLL---------------------------------------------------------------------- 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 267 pvmDLRALQDRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLL 346
Cdd:cd17503 171 ---DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLL 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 347 MAGLIGFAVSMYSFVPITHDWGADQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIALCG 426
Cdd:cd17503 248 LAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327
|
410 420
....*....|....*....|
gi 1820388781 427 TVLNDRTNLHYSRLADHLNN 446
Cdd:cd17503 328 TLLTNRTQFHHSRLSELLAQ 347
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
27-450 |
6.72e-43 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 156.56 E-value: 6.72e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 27 MCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGW 106
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 107 AWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVpg 186
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 187 iyIAVAVPLLVkvdsadptllrgadylsilllalslgcleytleegprwgwfddatltttawvallcgvafvirtlrhpq 266
Cdd:cd17321 159 --IGLVALLLA--------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 267 pvmdlralqdRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLL 346
Cdd:cd17321 168 ----------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 347 MAGLIGFAVSMYSFVPITHDWGADQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIALCG 426
Cdd:cd17321 238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
410 420
....*....|....*....|....
gi 1820388781 427 TVLNDRTNLHYSRLADHLNNANLA 450
Cdd:cd17321 318 ALLTAGLSANLGDSGVAALLSAAA 341
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-420 |
2.81e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 135.10 E-value: 2.81e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 14 SMPTAKKIFAFASMCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAAS 93
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 94 AAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENY 173
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 174 NWHWLFFINVVPGIyiavavpllvkvdsadptllrgadylsilllalslgcleytleegprwgwfddatlttTAWVALLC 253
Cdd:COG2814 162 GWRWVFLVNAVLAL----------------------------------------------------------LALLLLLR 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 254 GVAFVIRTLRHPQPVMDLRALQDRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFY 333
Cdd:COG2814 184 LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLA 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 334 SWLANRVDLRWLLMAGLIGFAVSMYSFVPITHDWGadqLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLM 413
Cdd:COG2814 264 GRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWL---LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
....*..
gi 1820388781 414 RNLGGAI 420
Cdd:COG2814 341 FFLGGPL 347
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
28-424 |
7.70e-32 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 125.37 E-value: 7.70e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 28 CVGMFIALIDIQIVSASLRDIGGGLSAGDDETvWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWA 107
Cdd:cd17502 2 MLALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 108 WNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGI 187
Cdd:cd17502 81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 188 YIAVAVpllvkvdsadptllrgadylsilllalslgcleytleegprwgwfddatltttawvallcgvafvirtlrhpqp 267
Cdd:cd17502 161 LALALL-------------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 268 vmdlralqdRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANR-VDLRWLL 346
Cdd:cd17502 167 ---------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKtGRYKPLI 237
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820388781 347 MAGLIGFAVSMYSFVPITHDWGADQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIAL 424
Cdd:cd17502 238 VIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-429 |
2.44e-26 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 110.36 E-value: 2.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 41 VSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQ 120
Cdd:cd17504 15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 121 GLAGGsMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAVPLlvkvd 200
Cdd:cd17504 95 GIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPL----- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 201 sadptllrgadylsilllalslgcleytleegprwgwfddatltttawvallcgvafvirtlrhpqpvMDLRALQDRTLS 280
Cdd:cd17504 169 --------------------------------------------------------------------IDLRLLRRRNVL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 281 LGCYFSFMAGVGIFATIYLTPLYLGSVR----GFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAGLIGFAVS 356
Cdd:cd17504 181 LANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVG 260
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1820388781 357 MYSFVpiTHDWGADQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIALCGTVL 429
Cdd:cd17504 261 LLLLA--LLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-297 |
8.74e-24 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 101.43 E-value: 8.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 14 SMPTAKKIFAFASMCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAAS 93
Cdd:COG0477 6 AAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 94 AAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENY 173
Cdd:COG0477 86 LLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 174 NWHWLFFINVVPGIYIAVAVPLL------VKVDSADPTLLRGADYLSILLLALSLGCLEYTLEEGPRWGWFDDATLTTTA 247
Cdd:COG0477 166 GWRWIFLINAPLGLLALVLRLRLpesrglLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1820388781 248 WVALLCGVAFVIRTLRHPQPVMDLRALQDRTLSLGCYFSFMAGVGIFATI 297
Cdd:COG0477 246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-421 |
4.83e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 97.10 E-value: 4.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 27 MCVGMFIALIDIQIVSASL-RDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCG 105
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 106 WAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVp 185
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 186 gIYIAVAVPLLVKVDSADPTLLRGADylsilllalslgcleytleegprwgwfDDATLTTTAWVALLCGVAFVIRTLrhp 265
Cdd:pfam07690 160 -LSLLAAVLLLLPRPPPESKRPKPAE---------------------------EARLSLIVAWKALLRDPVLWLLLA--- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 266 qpvmdlralqdrtlslgcyfSFMAGVGIFATIYLTPLYLgSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWL 345
Cdd:pfam07690 209 --------------------LLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRR 267
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820388781 346 LMAGLIGFAVSMYSFVPITHDWGADQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIG 421
Cdd:pfam07690 268 LLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
30-429 |
1.61e-21 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 97.49 E-value: 1.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 30 GMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWN 109
Cdd:PRK10504 18 GFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 110 IQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYI 189
Cdd:PRK10504 98 LNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 190 AVAVPLLVKVDSADPtllRGADYLSILLLALSLGCLEYTLeEGPRWGWFDDATLTTTAWVALLCGVAFVIRTLRHPQPVM 269
Cdd:PRK10504 178 AIATLMLMPNYTMQT---RRFDLSGFLLLAVGMATLTLAL-DGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 270 DLRALQDRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAG 349
Cdd:PRK10504 254 SLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVAT 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 350 LIGFAVSMYSFVPIT-HDWgadQLLLPQA--FRGLAQQFAVAPTVTLTLGSLPParlKLASG---LFNLMRNLGGAIGIA 423
Cdd:PRK10504 334 TLGLALVSLLFMLVAlLGW---YYLLPFVlfLQGMVNSTRFSSMNTLTLKDLPD---NLASSgnsLLSMIMQLSMSIGVT 407
|
....*.
gi 1820388781 424 LCGTVL 429
Cdd:PRK10504 408 IAGLLL 413
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-429 |
1.10e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 90.70 E-value: 1.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 14 SMPTAKKIFAFASMCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAAS 93
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 94 AAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENY 173
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 174 NWHWLFFINVVPGIYIAVAvpllvkvdsadptllrgadylsilllalslgcleytleegprwgwfddatltttawvallc 253
Cdd:COG2271 162 GWRAAFLILGLPGLLLALL------------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 254 gvafvirtlrhpqpvmdlralqdrTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFY 333
Cdd:COG2271 181 ------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLG 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 334 SWLANRVD--LRWLLMAGLIGFAVSMYSFVPITHDWGAdqlLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFN 411
Cdd:COG2271 237 GWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALA---IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN 313
|
410
....*....|....*...
gi 1820388781 412 LMRNLGGAIGIALCGTVL 429
Cdd:COG2271 314 TFGFLGGALGPLLVGYLL 331
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
32-429 |
4.14e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 89.17 E-value: 4.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 32 FIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQ 111
Cdd:cd17474 9 LLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 112 SMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITEnYNWHWLFFINVVPGIYIAV 191
Cdd:cd17474 89 LLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 192 AVPLLVKVDSADPTLLRGADYLSILLLalslgcleytleegprwgwFDDATLTTTAWVALLCGVAFvirtlrhpqpvmdl 271
Cdd:cd17474 168 AILFLLPEPKEKAKSSSATKLRDLKKA-------------------LRGRGLLTFLVSAFLYFFLY-------------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 272 ralqdrtlslgcyfsfmagvgiFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYS-WLANRVDLRWLLMAGL 350
Cdd:cd17474 215 ----------------------FAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGL 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1820388781 351 IGFAVSMYSFVPITHDWgadQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIALCGTVL 429
Cdd:cd17474 273 LLYALSLLLLGFVPSLA---LLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
24-429 |
8.58e-17 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 81.85 E-value: 8.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 24 FASMCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLL 103
Cdd:cd17319 5 IPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 104 CGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINV 183
Cdd:cd17319 85 TGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 184 VPGIYIAVAvpllvkvdsadptllrgadylsilllalslgcleytleegprwgWFddatltttawvallcgvaFVIRTLr 263
Cdd:cd17319 165 LLGLLLAVL--------------------------------------------WW------------------FYLRQV- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 264 hpqpvmdlralqdrtlsLGCYFS-FMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDL 342
Cdd:cd17319 182 -----------------WGLALGyFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 343 ---RWLLMAGLIGFAVSMYSFVPITHDWGADQLLlpqAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGA 419
Cdd:cd17319 245 garRLVIIIGLLLAAVGLLLAYLTTSPVVAVILL---SLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGF 321
|
410
....*....|
gi 1820388781 420 IGIALCGTVL 429
Cdd:cd17319 322 VAPLLIGYLV 331
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
25-516 |
9.51e-17 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 83.06 E-value: 9.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 25 ASMCVGMFIALIDIQIVSASLRDIGGGLsAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLC 104
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADL-GPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 105 GWAWNIQSMIAFRALQGLAGGsMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYN--WHWLFFIN 182
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAG-TQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYIN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 183 VvpGIYIAVAVPLLV---------KVDSADPTLLRGADYLSILLLALSLGCLEYTLEEGP-RWGWFDDATLTTTAwVALL 252
Cdd:cd06179 159 A--IFNALALILLFFfyhppprpqLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGnPYPWSSAHVIAPLV-IGGV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 253 CGVAFVIRTLRHP--QPVMDLRALQDRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSI 330
Cdd:cd06179 236 LLIAFGLYEWKGTkdGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 331 PFYSWLANRV-DLRWLLMAGLIGFAVSMYSFVPITHDWGAdQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGL 409
Cdd:cd06179 316 ILAGLLLTKIkHIKWQLVAGFVLFTAFLALLALITPDNKA-LAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGL 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 410 FNLMRNLGGAIGIALCGTVLNDRTNLH-YSRLADHLNNANLAMSDFVQ--------RSAANFTVQGISPDAAQTAAlknl 480
Cdd:cd06179 395 LGSARALGGAVGTAIFTSILSNRLSKNlPARVAPAALEAGLPASSLPAllgalasgNIAALTAVPGINPEIIAAAT---- 470
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1820388781 481 salalrEARTQAFSDAF---YLIMMGF----LLAALLVPLMKK 516
Cdd:cd06179 471 ------AALKQAYADSFryvWYAAIPFgvvaIIAALFLRDIDS 507
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-421 |
5.95e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 79.54 E-value: 5.95e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 28 CVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWA 107
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 108 WNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFinVVPGI 187
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL--VCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 188 YIAVAVPLLVKVDSADPTLLRGADYLSILLLalslgcleytleegprwgwfddatltttawvallcgvafVIRTLRHPQP 267
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRS---------------------------------------GLRLLLRDRR 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 268 VMdlralqdrtLSLGCYFSFMAGVGIFATIYltPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLM 347
Cdd:cd17325 201 LL---------ALFLAIFVLAFAFGALEPFL--PLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1820388781 348 AGLIGFAVSMYSFVPITHDWgadQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIG 421
Cdd:cd17325 270 IGLLLSAVALLLLPLATSFW---LLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-437 |
2.10e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 74.77 E-value: 2.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 27 MCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGW 106
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 107 AWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPG 186
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 187 IYIAVAVPLLVKVDSADPTLLRGADYLSILLLALSLgcleytleegprwgwfddatltttawvallcgvafvirtlrhpq 266
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 267 pvmdLRALQDRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRV-DLRWL 345
Cdd:cd06174 197 ----KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 346 LMAGLIGFAVSMYSFVPITHDWgadQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIALC 425
Cdd:cd06174 273 LLIGLLLMALGLALLLLAPSLL---LLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349
|
410
....*....|..
gi 1820388781 426 GTVLNDRTNLHY 437
Cdd:cd06174 350 GFLLAATFGLTG 361
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-417 |
9.78e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 72.61 E-value: 9.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 40 IVSASLRDIGGGLSAGDDETV-WVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRA 118
Cdd:cd17473 17 AIAPALPAIAQHFVPNSELLVpLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 119 LQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITEnYNWHWLFFinvvpgIYiAVAVPLLVk 198
Cdd:cd17473 97 LLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFL------VY-LLALPVLI- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 199 vdsadptllrgadylsilllalslgcleytleegprwgwfddatltttawvallcgvaFVIRTLRHPQPVMD-------- 270
Cdd:cd17473 168 ----------------------------------------------------------LVLLFLPEPARKSKsaaspgaa 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 271 -LRALQDRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAG 349
Cdd:cd17473 190 tAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820388781 350 LIGFAVSmYSFVPITHDWGAdqLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLG 417
Cdd:cd17473 270 FALMALG-FLLLALASGLWV--VLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
61-421 |
8.12e-13 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 70.06 E-value: 8.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 61 WVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQ 140
Cdd:TIGR00893 33 YVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYILRVLLGAAEAPFFPGIILIVASWFP 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 141 GKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAVPLLVKvdsadptllrgadylsilllal 220
Cdd:TIGR00893 113 ASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIWGVLWLKFIP---------------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 221 slgcleytleEGPRWGWFDDATLTTTAWVALLCGVAFVIRtlRHPQPVMDLRALQDRTLSLGCYFSFMAGVGIFATIYLT 300
Cdd:TIGR00893 171 ----------DPPQKAKWLTEEEKYIVVGGLLAEQQGKGP--STPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 301 PLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLAN-----RVDLRWLLMAGLIGFAVSMYSFVpITHDWGADQLLLP 375
Cdd:TIGR00893 239 PTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDlllrrGKSLVFARKTAIIAGLVLSLLMF-ATNYVNIPYAALA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1820388781 376 QAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIG 421
Cdd:TIGR00893 318 LVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVG 363
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
25-428 |
1.75e-12 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 68.83 E-value: 1.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 25 ASMCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLC 104
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 105 GWAWNIQSMIAFRALQGLAGGSMIP----LVFTTafaFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFF 180
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPnamaLLGRT---YPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 181 InvvpgiyiavavpllvkvdsadptllrgadylsilllalslgcleytleegprwgwfddatlttTAWVALLCGVAFVIR 260
Cdd:cd17476 158 F----------------------------------------------------------------LAILAAIVAVAAIFW 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 261 TLRHPQPVMdlralqdrtlslGCYFSFMAGVGIFatIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRV 340
Cdd:cd17476 174 TSPSFIAVL------------LAVFLGWASFGIW--VFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARL 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 341 DLRWLLMAGLIGFAVSMYSFVPIThdwgADQLLLPQAF-----RGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRN 415
Cdd:cd17476 240 PPSYIMAISMVAFLVGPILFATMP----VHQTYWAQAFpamivAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVN 315
|
410
....*....|...
gi 1820388781 416 LGGAIGIALCGTV 428
Cdd:cd17476 316 YGISIGLGIAGTV 328
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-429 |
4.68e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.57 E-value: 4.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 26 SMCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCG 105
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 106 WAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVP 185
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 186 GIYIAVAVPLLVKVDSADPTLLRGAdylsilllalslgcleytleegprwgwfddatltttawvallcgVAFVIRTLRHP 265
Cdd:cd17324 163 ALLAALLLWRLLPSLPPKKPGSLGL--------------------------------------------LSSLLLLLRNP 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 266 QPvmdlralqdRTLSLGCYFSFMAGVGIFATIyltPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVdLRWL 345
Cdd:cd17324 199 RL---------RLAYLITFLLFGGFFALYTYL---APFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG-GRRA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 346 LMAGLIGFAVSMYSFVPITHDWGAdqLLLPQAFRGLAqQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIALC 425
Cdd:cd17324 266 LLIALLLLAAALLLLTLLGPSPLL--LLVGLVLWGLG-FFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALG 342
|
....
gi 1820388781 426 GTVL 429
Cdd:cd17324 343 GLVL 346
|
|
| MFS_effux_SdrM |
NF040895 |
multidrug efflux MFS transporter SdrM; |
31-197 |
1.59e-11 |
|
multidrug efflux MFS transporter SdrM;
Pssm-ID: 468830 [Multi-domain] Cd Length: 441 Bit Score: 66.15 E-value: 1.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 31 MFIALIDIQIVSASLRDIGGGLSAGDdETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNI 110
Cdd:NF040895 15 MFMAAIETSIISLALPTIKEDLNAGS-SISLVFTVYFIALVIANPIVGELLSRFKIIYITILGLLLFIIGSLMSGLSETF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 111 QSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINvvpgIYIA 190
Cdd:NF040895 94 TMLIISRIIQGLGAGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFFIN----IPIA 169
|
....*..
gi 1820388781 191 VAVPLLV 197
Cdd:NF040895 170 IIAIILV 176
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
87-183 |
1.10e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 63.36 E-value: 1.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 87 RWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVG 166
Cdd:cd17323 64 RPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIG 143
|
90
....*....|....*..
gi 1820388781 167 GWITENYNWHWLFFINV 183
Cdd:cd17323 144 GFITQSLGWRWIFWFLA 160
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
64-198 |
4.94e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 57.66 E-value: 4.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 64 TSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQ 143
Cdd:TIGR00880 5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1820388781 144 RVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAVPLLVK 198
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
36-429 |
5.03e-10 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 61.67 E-value: 5.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 36 IDIQIVSASLRDIGGGLSAGDDETVWVQTSY-LIAEIIIIPLSGWLARVMSTRWLFAASAAgFTLMSLLCGWAWNIQSMI 114
Cdd:PRK14995 20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYsLVMAGMVLPMGALGDRIGFKRLLMLGGTL-FGLASLAAAFSPTASWLI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 115 AFRALQGLAGGSMIPLVFT-TAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAV 193
Cdd:PRK14995 99 ATRALLAIGAAMIVPATLAgIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 194 PLLVKVDSADPTllRGADYLSILLLALSLGCLEYTLEEGPRwGWFDDATLTTTAWVALLCGVAFVIRTLRHPQPVMDLRA 273
Cdd:PRK14995 179 ARYVPRQAGRRD--QPLNLGHALMLIVAILLLVYSAKTALK-GFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 274 LQDRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAGLIGF 353
Cdd:PRK14995 256 FTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALS 335
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1820388781 354 AVSMYSFVPI---THDWGADQLLlpqAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIALCGTVL 429
Cdd:PRK14995 336 ALSFYGLAMTdfsTQQWQAWGLM---ALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLL 411
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-429 |
2.03e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.51 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 23 AFASMCVGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSL 102
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 103 LCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFIN 182
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 183 VVPGIYIAVAVPLLVKVDSADPTLLRGADylsilllalslgcleytleegprwgwfddatltttawvallcgVAFVIRTL 262
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAAKAS-------------------------------------------LRDQLEAL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 263 RHPqpvmdlralqdRTLSLGCYFSFMAGVGIFATIYLtPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDL 342
Cdd:COG2223 203 RDP-----------RFWLLSLLYFGTFGSFIGFSSWL-PPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 343 RWLLMAGLIGFAVSMYSFVPITHDWGADQLLLpqAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGI 422
Cdd:COG2223 271 RRVLLIVFALMALGLLLLALALGSLWLFLVLF--LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGP 348
|
....*..
gi 1820388781 423 ALCGTVL 429
Cdd:COG2223 349 LLFGALL 355
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
31-431 |
6.45e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 57.97 E-value: 6.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 31 MFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNI 110
Cdd:cd17320 8 VALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 111 QSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIA 190
Cdd:cd17320 88 EQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 191 VAVPLLVKvdsadptllrgadylsilllalslgcleYTLEEGPRwgwfddatltTTAWVALLCGVAFVIRTlrhpqpvmd 270
Cdd:cd17320 168 LLVLLFLP----------------------------ETLPEEKR----------KPLLSSLLRAYKRVLKN--------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 271 lRALQDRTLSLGCYFsfmagVGIFATIYLTPLYLGSVRGFSALEIGLA-VFSTGLFQVMSIpFYSWLANRVDLRWLLMAG 349
Cdd:cd17320 201 -RRFLGYALALGLSF-----AGLFAYLAAAPFIYIEQLGLSPAQFGLLfALNAIALILGSL-LNGRLVRRFGPRRLLRLG 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 350 LIGFAVS--MYSFVPITHDWGADQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARlKLASGLFNLMRNLGGAIGIALCGT 427
Cdd:cd17320 274 LLLLLAAalVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVA-GTASALLGFLQFLIGALAGALVGL 352
|
....
gi 1820388781 428 VLND 431
Cdd:cd17320 353 LPNG 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
286-424 |
7.23e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.35 E-value: 7.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 286 SFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAGLIGFAVSMYSFVPITH 365
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1820388781 366 DWgadQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIAL 424
Cdd:pfam07690 85 LW---LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLL 140
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
29-429 |
1.65e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.51 E-value: 1.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 29 VGMFIALIDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAW 108
Cdd:TIGR00895 24 LIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 109 NIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINvvpGIY 188
Cdd:TIGR00895 104 NVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVG---GIA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 189 IAVAVPLLVKV--DSADPTLLRGADYLSILLLALSLGCLEYTLEEGPRWGWFDDatltttawvallcgvafvirTLRHPQ 266
Cdd:TIGR00895 181 PLLLLLLLMRFlpESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQG--------------------TKRSVF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 267 PVMDLRALQDRTLSLGCYFSFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLfqVMSIPFYSWLANRVDLRwLL 346
Cdd:TIGR00895 241 KALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGG--VIGSIIFGWLADRLGPR-VT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 347 MAGLIGFAVSMYSFVPITHDwgADQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPA-RLKLASGLFNLMRnLGGAIGIALC 425
Cdd:TIGR00895 318 ALLLLLGAVFAVLVGSTLFS--PTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAiRATGVGWAIGIGR-LGAIIGPILA 394
|
....
gi 1820388781 426 GTVL 429
Cdd:TIGR00895 395 GYLL 398
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
76-199 |
1.79e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.91 E-value: 1.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 76 LSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLA 155
Cdd:cd17316 55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGW 134
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1820388781 156 SLAPTLGPTVGGWI----TENYNWHWLFFINVVPGIYIAVAVPLLVKV 199
Cdd:cd17316 135 ALGALLAALVASLLipllSGDWGWRILFLIGALPALLALLLRRRTLLL 182
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
281-429 |
4.65e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 4.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 281 LGCYFSFMAGVGIFATiyLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAGLIGFAVSMYSF 360
Cdd:COG2211 234 LLAYLLFFLALALVAA--LLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820388781 361 VPITHDWGAdQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLK-------LASGLFNLMRNLGGAIGIALCGTVL 429
Cdd:COG2211 312 FFLGPGNLW-LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
76-197 |
4.88e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.91 E-value: 4.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 76 LSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRviaaATIGGLA 155
Cdd:TIGR00881 49 VMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSER----GTWVSFW 124
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1820388781 156 SLAPTLG-----PTVGGWITENYNWHWLFFinvVPGIyIAVAVPLLV 197
Cdd:TIGR00881 125 NCSHNVGggllpPLVLFGIAELYSWHWVFI---VPGI-IAIIVSLIC 167
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
67-433 |
5.53e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.81 E-value: 5.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 67 LIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLV-FTTAFAFFQGKQRV 145
Cdd:cd17355 48 LLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVaFATVAAWWFERRRG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 146 IAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAVPLLVKVDSADPTLlrgadylsilllalslgcL 225
Cdd:cd17355 128 LALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLAL------------------R 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 226 EYTLEEGPRWGWFDDATLTTTAWVALLCGVafvirtlrhpqpvmdlralqdrtlslgcyfsFMAGVGIFATIYLTPLYLG 305
Cdd:cd17355 190 AYDDASPASPGSTLKEALRSASFWLLALAF-------------------------------FLCGFAVVGLIVHLVPYLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 306 SvRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAGLIGFAVSMysFVPITHDWGADQLLLPQAFRGLAQQF 385
Cdd:cd17355 239 D-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGL--ALLLLLPFPPLALLLFAALFGLGWGA 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1820388781 386 AVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGiALCGTVLNDRT 433
Cdd:cd17355 316 TVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALG-PWLGGLLYDRT 362
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
97-198 |
6.08e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 48.53 E-value: 6.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 97 FTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWH 176
Cdd:TIGR00710 80 FALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWH 159
|
90 100
....*....|....*....|..
gi 1820388781 177 WLFFINVVPGIYIAVAVPLLVK 198
Cdd:TIGR00710 160 AIFAFLSLAGILLSALIFFILP 181
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
61-198 |
9.87e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.94 E-value: 9.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 61 WVQTSYLIAEIIIIPLSGWLARVM--STRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAF 138
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 139 FQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAVPLLVK 198
Cdd:COG2271 300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
76-193 |
2.14e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.81 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 76 LSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLA 155
Cdd:cd17365 53 LAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGY 132
|
90 100 110
....*....|....*....|....*....|....*...
gi 1820388781 156 SLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAV 193
Cdd:cd17365 133 PLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLL 170
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
61-191 |
3.92e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 45.65 E-value: 3.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 61 WVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQ 140
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1820388781 141 GKQRVIAAATIGGLASLAPTLGPTVGGWITenyNWHWLFFINVVPGIYIAV 191
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAYLIR---DWRWLQLAISLPGLLFLL 156
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
64-428 |
4.10e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.66 E-value: 4.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 64 TSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLaGGSMIPLVFTTAFAFFQGKQ 143
Cdd:cd17489 38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI-GWGAFTTAAATLVADIIPPS 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 144 RVIAAATIGGLA-SLAPTLGPTVGGWITENYNWHWLFFINVVpgiyIAVAVPLLVkvdsadptllrgadylsilllalsl 222
Cdd:cd17489 117 RRGEGIGYYGLAtTLAMALGPALGLFLYQHLGFAVLFIVAAV----LALLALLLV------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 223 gcleytleegprwgwfddatltttawvaLLCGVAFVIRTLRHPQPVMDLRALQDRTLSLGCYFSFMAGVGIFATIYLTPL 302
Cdd:cd17489 168 ----------------------------FLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 303 YLGSvRGFSALEIGLAVFSTGLfqVMSIPFYSWLANRVDLRWLLMAGLIGFAVSMYSFVPITHDWgadQLLLPQAFRGLA 382
Cdd:cd17489 220 YAAE-RGISNAGLFFTVYAIAL--LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPW---MLLLAAVLYGLG 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1820388781 383 QQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIALCGTV 428
Cdd:cd17489 294 FGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
286-424 |
4.71e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 4.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 286 SFMAGVGIFATIYLTPLYLGSVrGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAGLIGFAVSMYSFVPITH 365
Cdd:COG2814 19 AFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS 97
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1820388781 366 DWgadQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIAL 424
Cdd:COG2814 98 LW---LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
76-197 |
5.75e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.25 E-value: 5.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 76 LSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLA 155
Cdd:cd17474 254 VGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVR 333
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1820388781 156 SLAPTLGPTVGGWITENYNWHWLFFInvvpGIYIAVAVPLLV 197
Cdd:cd17474 334 FLGQAVGPLLFGLLLEIFGLSAPFLV----GAAIALAAAVLL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
287-424 |
7.78e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.89 E-value: 7.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 287 FMAGVGIFATIYL----TPLYLgSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAGLIGFAVSMYSFVP 362
Cdd:cd17489 2 LLANFFFFLSFYLllpvLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1820388781 363 ITHDWGadqLLLPQAFRGLAqqFAVAPTVTLTLGS--LPPARLKLASGLFNLMRNLGGAIGIAL 424
Cdd:cd17489 81 ATSVAL---LLVLRLIHGIG--WGAFTTAAATLVAdiIPPSRRGEGIGYYGLATTLAMALGPAL 139
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
57-181 |
8.66e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.92 E-value: 8.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 57 DETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWA--WNIQSMIAFRALQGLAGGSMIPLVFTT 134
Cdd:cd17318 56 KTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAarGGYGALIVLRILQGLAQGVTFPAMHAL 135
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1820388781 135 AFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFI 181
Cdd:cd17318 136 WAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYI 182
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
252-458 |
2.23e-04 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 43.84 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 252 LCGVAFVIRTLRH-PQPVMDLRALQDRTLSLGCYFSFMagvgIFATIYLTPLYLGSVRGFSA-LEIGLAVFSTGLFQVMS 329
Cdd:cd17322 259 VLLVAFLLWEAKFaKYPFLPFRLLKDRTILAACLIDFF----YFFSYYIFSDYLYTVLQVAVgESITSATRITNLYSFVS 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 330 I---PFYSWLANRVD-LRWLLMAGLIGFAVSM---YSFVPITHDWGadQLLLPQAFRGLAQQFAVAPTVTLTLGSLPPAR 402
Cdd:cd17322 335 TvagIFVGFLIRKTRrYKVLVIIGVPLYIVGMgllIRYRGGSGSHG--GIIGALILIGIGGGLFTYPVQVSVQASVSHQE 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820388781 403 LKLASGLFNLMRNLGGAIGIALCGTVLndrTNLHYSRLADHLNNANLA------MSDFVQRS 458
Cdd:cd17322 413 MAVVTALLLTVYSIGGAVGAAISGAIW---TQTLPKKLLKNLPDSLKAtaayifPSTFVILS 471
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
57-207 |
2.45e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 43.39 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 57 DETVWVQTSYLIAEIII-IPLSGWLARVMSTRWLfAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIP-LVFTT 134
Cdd:cd17327 41 NQYNWGNTVFYVGYIIFeLPGNLLLQRFPPSKWL-SVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPgFILYL 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1820388781 135 AfAFFQGKQRVIAAA---TIGGLASLAPTLGPTVGGWITEN---YNWHWLFFINVVPGIYIAVAVPLLVKVDSADPTLL 207
Cdd:cd17327 120 G-MWYKREEQAKRIAffyAAAGLGSIFGGLLAYGVFKILGVgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFL 197
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
28-442 |
2.89e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 43.38 E-value: 2.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 28 CVGMFIAL---IDIQIVSASLRDIGGGLSAGDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLC 104
Cdd:cd17328 2 AVLFLINLlnyMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 105 GWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITE-NYNWHWLFFINV 183
Cdd:cd17328 82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 184 VPGIYIAVAVPLLVKVdsadptllrgadylsilllalslgcleytleegPRWGWFDDATLTTTAWVALLCGVAFVIRtlr 263
Cdd:cd17328 162 VLGVLLAILLLLFVRE---------------------------------PPRGAAEGGVMAKSTATSFLADLKALAK--- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 264 hpQPVMDLRALQdrtlslGCYFSFMAGvgifATIYLTPLYLGSVRGFS-------ALEIGLAVFSTGLFQVMSIPFYSWL 336
Cdd:cd17328 206 --NPSFILSTLG------FTAVSFVTG----ALAFWAPTFFLRAFGVGdlssadvGLIFGAITCIAGVLGVLLGGILADR 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 337 ANRVDLRWLLMAGLIGFAVSMYsFVPITHDWGADQLLLPQAFRGLAQQFAV---APTVTLTLGSLPPARLKLASGLFNLM 413
Cdd:cd17328 274 LRRKTPRADPLVCAVGLLAAAP-FLFLALVLALSNLLLAWVLLFLGEFLLSlnwAPVFAILLYVVIPTRRSTASAIQILL 352
|
410 420 430
....*....|....*....|....*....|
gi 1820388781 414 RN-LGGAIGIALCGTVLNDRTNLHYSRLAD 442
Cdd:cd17328 353 SHlLGDAGSPYLIGLISDLLRQNKDSPLAE 382
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
61-181 |
3.05e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 42.93 E-value: 3.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 61 WVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWA--WNIQSMIAFRALQGLAGGSMIPLVFTTAFAF 138
Cdd:cd17380 38 LVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRW 117
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1820388781 139 FQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFI 181
Cdd:cd17380 118 VPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
76-203 |
5.94e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.15 E-value: 5.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 76 LSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFqGKQRVIAAATIGGLA 155
Cdd:COG0738 265 LGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL-GKRTAAAVSAVLIMG 343
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1820388781 156 SLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAVPLLVKVDSAD 203
Cdd:COG0738 344 IVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
61-198 |
8.31e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 8.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 61 WVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSmIPLVFTTAFAFFQ 140
Cdd:cd17330 38 LLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITD 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1820388781 141 GKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAVPLLVK 198
Cdd:cd17330 117 EEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP 174
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
97-198 |
9.15e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.44 E-value: 9.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 97 FTLMSLLCGWAWNIQSMIAFRALQGLAGGSmiPLVFTTAFA--FFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYN 174
Cdd:PRK11102 66 FALAAVACALAQTIDQLIYMRFLHGLAAAA--ASVVINALMrdMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFS 143
|
90 100
....*....|....*....|....
gi 1820388781 175 WHWLFFINVVPGIYIAVAVPLLVK 198
Cdd:PRK11102 144 WHAIFWVLALAAILAAALVFFFIP 167
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
286-431 |
2.72e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.29 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 286 SFMAGVGIFATIYLTPLYLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAGLIGFAVSMYSFVpITH 365
Cdd:cd17329 8 SFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG-FAH 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820388781 366 DWGADQLLLpqAFRGLAQQFAVAPTVTLTLGSLPPARLKLASGLFNLMRNLGGAIGIALCGTVLND 431
Cdd:cd17329 87 SPWLFAIAL--VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY 150
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
55-193 |
4.97e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.08 E-value: 4.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 55 GDDETVWVQTSYLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWN-IQSMIAFRALQGLAGGSMIPLVFT 133
Cdd:cd17477 221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGlPLALLVLLFLWGGAAGPLYTLALA 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 134 TAFAFFQGKQRVIAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAV 193
Cdd:cd17477 301 LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
303-430 |
7.14e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.90 E-value: 7.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 303 YLGSVRGFSALEIGLAVFSTGLFQVMSIPFYSWLANRVDLRWLLMAGLIGFAVSMYSFVPITHDWgadQLLLPQAFRGLA 382
Cdd:TIGR00881 20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLW---VMAALWALNGIF 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1820388781 383 QQFAvAPTVTLTLGSL-PPARLKLASGLFNLMRNLGGAIGIALCGTVLN 430
Cdd:TIGR00881 97 QGMG-WPPCGRTVTKWfSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIA 144
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
66-198 |
7.65e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 38.85 E-value: 7.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820388781 66 YLIAEIIIIPLSGWLARVMSTRWLFAASAAGFTLMSLLCGWAWNIQSMIAFRALQGLAGGSMIPLVFTTAFAFFQGKQRV 145
Cdd:PRK10473 47 YLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRA 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1820388781 146 IAAATIGGLASLAPTLGPTVGGWITENYNWHWLFFINVVPGIYIAVAVPLLVK 198
Cdd:PRK10473 127 KVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILK 179
|
|
| |
