NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1820391673|ref|WP_165472962|]
View 

RusA family crossover junction endodeoxyribonuclease [Enterobacter roggenkampii]

Protein Classification

RusA family crossover junction endodeoxyribonuclease( domain architecture ID 10531192)

RusA family crossover junction endodeoxyribonuclease similar to crossover junction endodeoxyribonuclease RusA that resolves Holliday junction intermediates and promotes DNA repair

CATH:  3.30.1330.70
EC:  3.1.21.10
Gene Ontology:  GO:0006281|GO:0006310|GO:0000287|GO:0000400|GO:0008821
PubMed:  17028102|10482492

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RusA pfam05866
Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday ...
 6-115 2.01e-20

Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC.


:

Pssm-ID: 428654  Cd Length: 124  Bit Score: 79.64  E-value: 2.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820391673   6 ITPIGKPRmtrsDRWRSR-------PETSAY-----WFFKAQVRRlgiTLPESGY---HITFVLPMPKSWSKKKRQQHEG 70
Cdd:pfam05866   1 GPPVGKGR----PRFRRVggrtytpEKTKAYenlvkLYLAQQMPG---RPPLEGPvkvEIKAYFPIPKSWSKKKRALEGK 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1820391673  71 QPHQTKPDKDNLEKALLDAI----FDDDCRIWDGRVTKRWGETGQIIIQ 115
Cdd:pfam05866  74 IRPTKKPDIDNLAKALLDALnggvWKDDSQVVDIIVEKFYSEEPRVEVE 122
 
Name Accession Description Interval E-value
RusA pfam05866
Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday ...
 6-115 2.01e-20

Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC.


Pssm-ID: 428654  Cd Length: 124  Bit Score: 79.64  E-value: 2.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820391673   6 ITPIGKPRmtrsDRWRSR-------PETSAY-----WFFKAQVRRlgiTLPESGY---HITFVLPMPKSWSKKKRQQHEG 70
Cdd:pfam05866   1 GPPVGKGR----PRFRRVggrtytpEKTKAYenlvkLYLAQQMPG---RPPLEGPvkvEIKAYFPIPKSWSKKKRALEGK 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1820391673  71 QPHQTKPDKDNLEKALLDAI----FDDDCRIWDGRVTKRWGETGQIIIQ 115
Cdd:pfam05866  74 IRPTKKPDIDNLAKALLDALnggvWKDDSQVVDIIVEKFYSEEPRVEVE 122
RusA COG4570
Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination ...
 71-119 1.27e-07

Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination and repair];


Pssm-ID: 443627  Cd Length: 120  Bit Score: 46.42  E-value: 1.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1820391673  71 QPHQTKPDKDNLEKALLDA-----IFDDDCRIWDGRVTKRWGETGQ---IIIQENAE 119
Cdd:COG4570    63 PPDRRKPDLDNLLKAILDAltgagVWKDDSQVVDLIVEKRYDDKGPrveVEIEELEE 119
 
Name Accession Description Interval E-value
RusA pfam05866
Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday ...
 6-115 2.01e-20

Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC.


Pssm-ID: 428654  Cd Length: 124  Bit Score: 79.64  E-value: 2.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820391673   6 ITPIGKPRmtrsDRWRSR-------PETSAY-----WFFKAQVRRlgiTLPESGY---HITFVLPMPKSWSKKKRQQHEG 70
Cdd:pfam05866   1 GPPVGKGR----PRFRRVggrtytpEKTKAYenlvkLYLAQQMPG---RPPLEGPvkvEIKAYFPIPKSWSKKKRALEGK 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1820391673  71 QPHQTKPDKDNLEKALLDAI----FDDDCRIWDGRVTKRWGETGQIIIQ 115
Cdd:pfam05866  74 IRPTKKPDIDNLAKALLDALnggvWKDDSQVVDIIVEKFYSEEPRVEVE 122
RusA COG4570
Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination ...
 71-119 1.27e-07

Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination and repair];


Pssm-ID: 443627  Cd Length: 120  Bit Score: 46.42  E-value: 1.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1820391673  71 QPHQTKPDKDNLEKALLDA-----IFDDDCRIWDGRVTKRWGETGQ---IIIQENAE 119
Cdd:COG4570    63 PPDRRKPDLDNLLKAILDAltgagVWKDDSQVVDLIVEKRYDDKGPrveVEIEELEE 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH