|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
5-403 |
5.80e-68 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 220.56 E-value: 5.80e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 5 RRTLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGA 84
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 85 GLALASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSM-CVPIAASnLIEHFGITFA 163
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLiFSPLIAY-LINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 164 LLIFGLVCGSVIAAAGILSGAATSAGVSHEITqalaalrnrpLAASHSTLPVQDKNWKEMLASPVFYAMLVLFICGSTGA 243
Cdd:cd17353 160 FLILGIIFLIIIVIGAFLIRDPPKGWVPPGVD----------PLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 244 LMLIPSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVsLFAAMSGLMLLLCSGTDDVTTFLA 323
Cdd:cd17353 230 LMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSI-AFLIQGVAMFLLPFIGSVAVLFVL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 324 GLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFSGASDFSQA-YIAAEIVCLAGLGSLW 402
Cdd:cd17353 309 GVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAfIIAAALSLVALALALL 388
|
.
gi 1821496550 403 I 403
Cdd:cd17353 389 L 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-414 |
1.67e-44 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 159.28 E-value: 1.67e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 3 ISRRTLLLAVFCLaNLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMI 82
Cdd:COG2223 2 GRWRVLLLATLAF-FLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 83 GAGLALASCAESLLMLsVVYGLCFGFGVGLTYVSTLGTAMKLFP-DRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGIT 161
Cdd:COG2223 81 GIGLLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 162 FALLIFGLVCGSVIAAAGILsgaatsagvsheitqalaaLRNRPLAASHSTlPVQDKNWKEMLASPVFYAMLVLFICGST 241
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLF-------------------LRDPPAGAAAAA-KASLRDQLEALRDPRFWLLSLLYFGTFG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 242 GALMLIPSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSlFAAMSGLMLLLCSGTDDVTTF 321
Cdd:COG2223 220 SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV-FALMALGLLLLALALGSLWLF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 322 LAGLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFSGAS-DFSQAYIAAEIVCLAGLGS 400
Cdd:COG2223 299 LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVL 378
|
410
....*....|....
gi 1821496550 401 LWICRQLKTGAGAS 414
Cdd:COG2223 379 TLLLYRRPRRAAAA 392
|
|
| 2A0111 |
TIGR00890 |
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ... |
5-398 |
1.25e-37 |
|
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273323 [Multi-domain] Cd Length: 377 Bit Score: 140.27 E-value: 1.25e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 5 RRTLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGA 84
Cdd:TIGR00890 1 RWWYVLVGTVIMCFTSGYVYTWTLLAPPLGRYFGVGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 85 GLALASCAESLLMLSVVYGLCfGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFAL 164
Cdd:TIGR00890 81 GFTFYAIADSLAALYLTYGLA-SAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVINLEGVPAAF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 165 LIFGLVCGSVIAAAGILSGAATSAGVSHEItqalaalrnrplaashsTLPVQDKNWKEMLASPVFYAMLVLFICGSTGAL 244
Cdd:TIGR00890 160 IYMGIIFLLVIVLGAFLIGYPPGQLIKTNI-----------------EVSVKDYTVWEMLRTPQFWVLYLSFFLNAVSGL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 245 MLIPSAVMISmQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTDDVTTFLAG 324
Cdd:TIGR00890 223 LLIGLYKPYG-QSLGLSDGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLFIPMLNDVLFLAT 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821496550 325 LILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFSGASDFSQAYIAAEIVCLAGL 398
Cdd:TIGR00890 302 VALVFFTWGGTISLFPSLVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHALTEIGFEYTFIVTGAFALTSL 375
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
5-394 |
1.26e-28 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 115.59 E-value: 1.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 5 RRTLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGA 84
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 85 GLALASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFAL 164
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 165 LIFGLVCGSVIAAAGILsgaatsagvsheitqalaalrnRPLAASHSTLPVQ-----DKNWKEMLASPVFYAMLVLFICG 239
Cdd:cd17314 161 TILGILAAIVLSVVSLL----------------------GFKEPPDNQARLHvqkkkTQTMGEIFRDKVFWILFIAIFLV 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 240 STGALMLIPSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDR-IGRLPTLGVSLFAAMSGLMLLLCSGTDDV 318
Cdd:cd17314 219 LIGGFLFIANMASLVRSLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFfGGRLSTLSILLTILGLGLCAFLFLLKMTP 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1821496550 319 TTFLAGLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFsgaSDFSQAYIAAEIVC 394
Cdd:cd17314 299 VGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKF---YDRTPSYISAVYIY 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
6-402 |
7.29e-26 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 108.13 E-value: 7.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 6 RTLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAG 85
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 86 LALASCAESLLMLSVVYGLCFGFGVG-LTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFAL 164
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 165 LIFGLVCGSVIAAAGILSGAATsagvsheitqALAALRNRPLAASHSTLPVqdknWKEMLASPVFYAMLV-LFICGSTGA 243
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRP----------ADLALRAYDDASPASPGST----LKEALRSASFWLLALaFFLCGFAVV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 244 LMLIpsAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTDDVTTFLA 323
Cdd:cd17355 228 GLIV--HLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLF 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 324 GLILtTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLK-LFSGASDFSQAYIAAEIVCLAGLGSLW 402
Cdd:cd17355 306 AALF-GLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGlLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
8-403 |
5.70e-24 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 102.25 E-value: 5.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 8 LLLAVFCLANLFA-GSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGL 86
Cdd:cd17352 3 VVVFASFLVNFFTdGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 87 ALASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLI 166
Cdd:cd17352 83 LLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 167 FGLVCGSVIAAAGILsgaatsagvsheitqalaalrnrplaashstlpvqdknwkEMLASPVFyamLVLFICGSTGALML 246
Cdd:cd17352 163 LGGLCLNLCVCGLLL----------------------------------------RLLKDPTF---VLLALGVSFAMLGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 247 IPSAVMIS--MQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRiGRLPTLGVSLFA-AMSGLMLLLCSgtddVTTFLA 323
Cdd:cd17352 200 FVPFVYLPsyAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK-PRIGRLYLYIFTlLILGLSLLAFP----LATTYV 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 324 GLILTTVCYGSFVGVFPSLT----VETFGLKYNSVNYGIMAAGFSSAGILGPVLL-KLFSGASDFSQAYIAAEIVCLAGL 398
Cdd:cd17352 275 GLIVFSVLFGFCSGSYSSLTpvilADLVGLEKLSNAYGLVLLFQGLAALVGPPIAgLLRDYTGDYDAAFYFCGACLLLSG 354
|
....*
gi 1821496550 399 GSLWI 403
Cdd:cd17352 355 VLLFL 359
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-403 |
6.43e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.40 E-value: 6.43e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 5 RRTLLLAVFCLANLFAGSL-YSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIG 83
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDrSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 84 AGLALASCAESLLMLSVVYGLcFGFGVGLTYVSTLGTAMKLFPDRK-GLAGGLVTMSYGLSSMCVPIAASNLIEHFGITF 162
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFL-LGLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 163 ALLIFGLVCGSVIAAAgilsgaatsagvsheitqalaalrnrplaashstlpvqdknwkemlaspvFYAMLVLFICGSTG 242
Cdd:COG2271 166 AFLILGLPGLLLALLR--------------------------------------------------FWLLALAYFLVYFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 243 ALMLIPSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTDDVTTFL 322
Cdd:COG2271 196 LYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAI 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 323 AGLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFSGASDFSQAYIAAEIVCLAGLGSLW 402
Cdd:COG2271 276 ALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
.
gi 1821496550 403 I 403
Cdd:COG2271 356 L 356
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
8-373 |
1.38e-20 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 92.84 E-value: 1.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 8 LLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLA 87
Cdd:cd17423 4 VVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLGFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 88 LASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIF 167
Cdd:cd17423 84 LASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 168 G------LVCGSVIAAAGiLSGAATSAGVSHEITQALAALRNRPLAAshstlpvqdknwkemlaspvfYAMLVLFIcgst 241
Cdd:cd17423 164 SalslhlVPCGALLRPLA-LPGDPPAPPRSLSAAFGLSLLTHRAFLR---------------------YALATTLI---- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 242 GALMLIPSAVMIS-MQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTDDVTT 320
Cdd:cd17423 218 NTGYFIPYVHLVAhARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGS 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1821496550 321 FLAGLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVL 373
Cdd:cd17423 298 LLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPL 350
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
18-362 |
1.84e-16 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 80.37 E-value: 1.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 18 LFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSnDRFGPKYVLTVGGLMIGAGLALASCAESLLM 97
Cdd:cd17354 14 LSAGSIYLFSLYSPPLKSTLGYSQQQNNLLSVAKDLGYLVGPLLGLLS-DRLGPWLLLLIGAILFFPGYGVLWLVVTGLI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 98 LSV-VYGLCFGFGVG-----LTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFaLLIFGLVC 171
Cdd:cd17354 93 SDLsFWLMCLCFFLIgnstsSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGAIGSQLYKALFFHDSARV-FLFLAVLP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 172 GSVIAAAGILSGAATSAGVsheitqalaalrnrplaashstlpvqdknwkEMLASPVFYAMLVLFICGSTGALMLIPSav 251
Cdd:cd17354 172 AVVGLLAWFSVRIVSIEEG-------------------------------EFLKDIDFWLLFISLFLGVGPGEMFINN-- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 252 MISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISD----RIGRLPTLGVSLFAAMSGLMLLLCSGTDDVTTFLAGLIL 327
Cdd:cd17354 219 LGQIGQSLTGPSNTSTLVSLFSIFSFLGRLLSGLLSDlfvrKFRLPRPSRMVLLLLILSLGHLLQAFGLPSGALYVASAL 298
|
330 340 350
....*....|....*....|....*....|....*
gi 1821496550 328 TTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAG 362
Cdd:cd17354 299 IGFGYGGLFSIAPTIVSELFGLKNFGTNYGFLMLA 333
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
4-403 |
1.28e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.99 E-value: 1.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 4 SRRTLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIG 83
Cdd:COG2807 15 GRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 84 AGLALASCAESLLMLSVVYGLCfGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFA 163
Cdd:COG2807 95 AGLLLRSLAPSVALLLAGTALI-GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 164 LLIFGLVCgsviAAAGILsgaatsagvsheitqALAALRNRPLAASHSTLPVQdknWKEMLASPVFYAMLVLFICGSTGA 243
Cdd:COG2807 174 LAVWALLA----LLALLL---------------WLPLLRRRPAAAAAAPAAAS---LRSLWRSPLAWLLTLFFGLQSLLY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 244 LMLIPSAVMIsMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTDdvTTFLA 323
Cdd:COG2807 232 YAVVAWLPPI-LRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG--SLPWL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 324 GLILTTVCYGSFVGVFPSLTVETFG-LKYNSVNYGIMAAGFSSAGILGPVLL-KLFSGASDFSQAYIAAEIVCLAGLGSL 401
Cdd:COG2807 309 WAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVgALHDATGSWTAALLLLAALAVLMLVAG 388
|
..
gi 1821496550 402 WI 403
Cdd:COG2807 389 LL 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-369 |
5.06e-15 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 75.78 E-value: 5.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 4 SRRTLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIG 83
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 84 AGLALASCAESLLMLsVVYGLCFGFGVGLTYVSTLGTAMKLFP-DRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITF 162
Cdd:COG2814 87 LGSLLCALAPSLWLL-LAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 163 ALLIFGLVCGSVIAAAGILSGAATSAGVSHEITQALAALRNrplaashstlpvqdknwkemlasPVFYAMLVLFICGSTG 242
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRR-----------------------PRLLLLLLLAFLLGFG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 243 ALMLIPSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLfaAMSGLMLLLCSGTDDVTTFL 322
Cdd:COG2814 223 FFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL--LLLALGLLLLALAGSLWLLL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1821496550 323 AGLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGIL 369
Cdd:COG2814 301 LALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-371 |
5.17e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 72.84 E-value: 5.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 13 FCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCA 92
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 93 ESLLMLsVVYGLCFGFGVGLTYVSTLGTAMKLFPD-RKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFGLVC 171
Cdd:pfam07690 83 SSLWLL-LVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 172 GSVIAAAGILsgaatsagvsheitqaLAALRNRPLAASHSTLPVQDKNWKEMLASPVFYAMLVLFIcgSTGALMLIPSAV 251
Cdd:pfam07690 162 LLAAVLLLLP----------------RPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLL--FGFAFFGLLTYL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 252 MISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVS-LFAAMSGLMLLLCSGTDDVTTFLAGLILTTV 330
Cdd:pfam07690 224 PLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAlLLLILAALGLLLLSLTLSSLWLLLALLLLGF 303
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1821496550 331 CYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGP 371
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
4-398 |
5.75e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.88 E-value: 5.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 4 SRRTLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIG 83
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 84 AGLALASCAESLLMLSVVYgLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFA 163
Cdd:COG0738 85 LGLLLFALAPSYPLLLLAL-FLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 164 LLIFGLVCGSVIAAAGIlsgaatsagvsheitqaLAALRNRPLAASHSTLPVQDKNWKEMLASPVFYAMLVLFICGSTGA 243
Cdd:COG0738 164 HLPYLILAVLLLLLALL-----------------FLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 244 LMLIPSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTddVTTFLA 323
Cdd:COG0738 227 GAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPG--PWLALI 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1821496550 324 GLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGfSSAGILGPVLLKLFSGASDFSQAYIAAeIVCLAGL 398
Cdd:COG0738 305 GLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGAIGPPLIGFLADAFGLRAAFLVP-LVCYLLI 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
33-405 |
1.23e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.76 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 33 LAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVYGLcFGFGVGL 112
Cdd:cd17325 22 YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFL-QGLASAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 113 TYVSTLGTAMKLFP-DRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALlifgLVCGSVIAAAGILSGAATSAGVS 191
Cdd:cd17325 101 VWPAAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF----LVCAALALLALVLALLLLPEPRP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 192 HEITQALAALRNRplaashstlpvqdKNWKEMLASPVFYAMLVLFICGSTGALMLIPSAVMISMQQIGLTAQAAAGCVSA 271
Cdd:cd17325 177 PPNKRAVSAARLR-------------SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 272 LAVANTLGRVSGGLISDRIGRLPTLGVSLFAamSGLMLLLCSGTDDVTTFLAGLILTTVCYGSFVGVFPSLTVETFGLKY 351
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPLILIGLLL--SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1821496550 352 NSVNYGIMAAGFSSAGILGPVLLKLFSGASDFSQAYIAAEIVCLAGLGSLWICR 405
Cdd:cd17325 322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-402 |
2.01e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 58.98 E-value: 2.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 12 VFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASC 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 92 AESLLMLSVVYGLCfGFGVGLTYVSTLGTAMKLFPDR-KGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFGLV 170
Cdd:cd06174 81 APSFWLLLLGRFLL-GLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 171 CGSVIAAAGILsgaatsagVSHEITQALAALRNRPLAASHSTLPVqdknwKEMLASPVFYAMLVLFICGSTGALMLIPSA 250
Cdd:cd06174 160 ALALLAAILLL--------LVVPDPPESARAKNEEASSKSVLKLL-----KRVLKNPGLWLLLLAIFLVNLAYYSFSTLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 251 VMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTdDVTTFLAGLILTTV 330
Cdd:cd06174 227 PLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP-SLLLLLLLLLLLGF 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1821496550 331 CYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLL-KLFSGASDFSQAYIAAEIVCLAGLGSLW 402
Cdd:cd06174 306 GLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAgFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
16-404 |
1.76e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.09 E-value: 1.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 16 ANLFAGSLYSWSVFsepLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCAESL 95
Cdd:cd17475 8 ASLVAQGIPALAPF---LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 96 LMLsvvygLCFGFGVGLTYVSTLGTA----MKLFPDR-KGLAGGL----VTMSYGLSSMCVPIaasnLIEHFGITFALLI 166
Cdd:cd17475 85 PVL-----LVLLFLVGAGYGSVQPGGgraiMRWFPPReRGLAMGIrqtgVPLGGALAAALLPP----LALHYGWRAAFVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 167 FGLVCgsviaaagILSGAATSAGVSHEITQALAALRNRPLAAShstlpvqdknWKEMLASPVFYAmlvlfICGSTGALML 246
Cdd:cd17475 156 AGLVS--------ILAAVLFWLFYREPPAASAATESASTLLRS----------LKEVLRNRDVWL-----IAIAGALLVA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 247 IPSAVMISM-----QQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIG----RLPTLGVSLFAAMSGLMLLLCSGTDD 317
Cdd:cd17475 213 PQFALLTFLllflhDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrrRPVLVITAAIAAAALLVLSLLSPGTP 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 318 VTTFLAGLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFSGAS-DFSQAYIAaeIVCLA 396
Cdd:cd17475 293 LWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAThSYAPAWLA--LALLL 370
|
....*...
gi 1821496550 397 GLGSLWIC 404
Cdd:cd17475 371 VLAALLLL 378
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
45-181 |
4.15e-08 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 54.82 E-value: 4.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 45 AFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKL 124
Cdd:cd17428 41 AWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQY 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1821496550 125 FPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFGLVCGSVIAAAGIL 181
Cdd:cd17428 121 FDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLLIVGALALNLLACGSLM 177
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-182 |
5.70e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.50 E-value: 5.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 1 MLISRRTLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGL 80
Cdd:cd17325 194 LLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 81 MIGAGLALASCAESLLMLSVVYGLcFGFGVGLTYVSTLGTAMKLFPDRK-GLAGGLVTMSYGLSSMCVPIAASNLIEHFG 159
Cdd:cd17325 274 LSAVALLLLPLATSFWLLLLLLAL-LGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
170 180
....*....|....*....|...
gi 1821496550 160 ITFALLIFGLVCGSVIAAAGILS 182
Cdd:cd17325 353 FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
38-398 |
1.96e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.60 E-value: 1.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 38 SASAADLAFIFSVAAGI-NPFAmisgGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLML---SVVYGLCFGFgvgLT 113
Cdd:cd17489 30 EAVAGLVVGLFTLAALLaRPFA----GRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLlvlRLIHGIGWGA---FT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 114 YVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIfglvcGSVIAAAGILsgaatsagvshe 193
Cdd:cd17489 103 TAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV-----AAVLALLALL------------ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 194 itqaLAALRNRPLAASHSTLPVQDKNWKEMLASPVFYAMLVLFICgsTGALMLIPSAVMISMQQIGLTAQAAAGCVSALA 273
Cdd:cd17489 166 ----LVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLA--SIAYGAISTFLPLYAAERGISNAGLFFTVYAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 274 VanTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLlcSGTDDVTTFLAGLILTTVCYGSFVGVFPSLTVETFGLKYNS 353
Cdd:cd17489 240 L--LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLL--SFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRG 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1821496550 354 VNYGIMAAGFSSAGILGPVLLKLFSGASDFSQAYIAAEIVCLAGL 398
Cdd:cd17489 316 AANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLAL 360
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
34-398 |
5.94e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.06 E-value: 5.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 34 AQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVYGLcFGFGVGLT 113
Cdd:cd17316 28 EFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFL-QGIGIGGE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 114 YVSTLGTAMKLFPDRK-GLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFA---LLIFGLVCGSVIAAAgilsgaatsag 189
Cdd:cd17316 107 YPGASTYVAEFAPSKRrGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwriLFLIGALPALLALLL----------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 190 vsheitqalaalrnrplaashstlpvqdknWKEMLASPVFYAMLVLficGSTGALMLIPSavmISMQQIGLTAQAAAGCV 269
Cdd:cd17316 176 ------------------------------RRRTLLLILLWFFISF---GYYGLTTFLPT---YLQTVLGLSPATSSLYL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 270 SALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTDDVTTFLAGLILTTVCYGSFVGVFPSLTVETFGL 349
Cdd:cd17316 220 LLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPT 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1821496550 350 KYNSVNYGI-MAAGFSSAGILGPVLLKLFSGASDFSQAYIAAEIVCLAGL 398
Cdd:cd17316 300 EVRATGVGLsYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
7-399 |
6.63e-06 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 47.82 E-value: 6.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 7 TLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPF-AMISGGWSNdRFGPKYVLTVGGLMIGAG 85
Cdd:cd17422 3 AVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFtAPLSTVLSN-RFGHRPVVMVGGLLISLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 86 LALASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALL 165
Cdd:cd17422 82 MITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 166 IFGLVCGSVIaaagilsgaatsagvsheITQALAALRNRPlaashstlpvqdknwkemlaSPVFYAMLVLFicgsTGALM 245
Cdd:cd17422 162 VVGALQLNIV------------------VCGALLRVLKEP--------------------GFICYALFGLF----ATLGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 246 LIPSAVMISMQ-QIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTDDVTTFLAG 324
Cdd:cd17422 200 FAPQLYIIPLSlSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVC 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821496550 325 LILTTVCYGSFVGVFPSLTVE--TFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFsgaSDFSQAYIAAEIVCLAGLG 399
Cdd:cd17422 280 SIFYGFMFGTVAGTHIPLLAEddVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVL---VDWTQNYGSAFYSCAAGMA 353
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
33-401 |
1.41e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 33 LAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKY-----VLTVGGLMIGAGLALASCAESL-LMLSVVYGLCF 106
Cdd:COG2211 37 YTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLsPTGKLIYALVT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 107 GFGVGLTY------VSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFG--ITFALLIFGLVCGSVIAAA 178
Cdd:COG2211 117 YLLLGLAYtlvnipYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 179 GILSGAATsagvsheitqalaalRNRPLAASHSTLPVQDknWKEMLASPVFYAMLVLFICGSTGALMLIPSAVMISMQQI 258
Cdd:COG2211 197 FLLTFFGT---------------KERPVPEEEKVSLKES--LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 259 GLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTDDVTTFLAGLILTTVCYGSFVGV 338
Cdd:COG2211 260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVL 339
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1821496550 339 FPSLTVETFGL-----------KYNSVNYGIMAAGFSSAGILGPVLLKL--FSGASDFSQAYIAAEIVCLAGLGSL 401
Cdd:COG2211 340 PWAMLADVVDYdewktgrrregLYFGIFTFAIKLGQALAGALAGLLLALfgYVAGAAQSPSALTGIRLLFFLLPAV 415
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
49-407 |
1.50e-05 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 46.94 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 49 SVAAGINPFAmisGGWSNDRFGPKYvLTVGGLMIGAGLALASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLF-PD 127
Cdd:cd17343 48 SLAYAISKFI---GGVLSDQISARW-LFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFsPS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 128 RKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFGLVC--GSVIAAAgILSGAATSAGVSHEITQALAALRNRP 205
Cdd:cd17343 124 QFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAvvMSVVCLL-FIKNEPSDVGLNNIEEEESKGKKKKS 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 206 LAAshstlpvqDKNWKEMLASPVFYAM----LVLFI----CGSTGALMLIpsavmismQQIGLTAQAAAGCVSALAVANT 277
Cdd:cd17343 203 PRG--------ESTLKELLLSPFLWLLslgyLVVFGvktaVTDWGQLFLI--------QDKGQSALTGSSFMSSLEVGGF 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 278 LGRVSGGLISDRIGRLP----------TLGVSLFAAMSGLMLLLC----SGTDDVTTFLAGLILTTVCYGSFvGVFPSLT 343
Cdd:cd17343 267 VGSIAAGYLSDWAVAKHgsssrgnprmPLALVFMAGLTVSLHLFRvhitSDSSELFILLLGFLIGFSLYGPI-AIFGVIA 345
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821496550 344 VETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFSGASDFSQAYIAAEIVCLAGLGSLWICRQL 407
Cdd:cd17343 346 NESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
27-420 |
1.59e-05 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 47.04 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 27 SVFSEPLAQKLSASAADLAFIFS----VAAGINPFAMISGGwsndRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVY 102
Cdd:TIGR00892 39 TVFFKELQQIFQATYSETAWISSimlaVLYAGGPISSILVN----RFGCRPVVIAGGLLASLGMILASFSSNVIELYLTA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 103 GLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTM--SYGLSSMcvPIAASNLIEHFGITFALLIFG------LVCGSV 174
Cdd:TIGR00892 115 GFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAgsPVFLSTL--APLNQYLFESFGWRGSFLILGglllhcCVCGAL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 175 IAAAGilSGAATSAGVSHEITQalaalrnRPLAASHSTLPVQDKNWKEMLASPVF---------YAMLVLFICGSTGALM 245
Cdd:TIGR00892 193 MRPVG--PSQRVSKSKSKEGLP-------PDGSTKKLSKKSTAEKINRFLDFSLFthrgflvylSGNVIMFLGFFAPIIF 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 246 LIPSAvmismQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAM--SGLMLLLCSGTDDVTTFLA 323
Cdd:TIGR00892 264 LVPYA-----KDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALlfNGLTHLLCALAGDYTGLVI 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 324 GLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLL-KLFSGASDFSQAYIAA-EIVCLAGL--- 398
Cdd:TIGR00892 339 YCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAgRLVDATKNYKYIFYASgSIVVSAGLfla 418
|
410 420
....*....|....*....|..
gi 1821496550 399 GSLWICrqLKTGAGASAALPIR 420
Cdd:TIGR00892 419 IGNYIN--YRLLAKEQKAALER 438
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
8-398 |
2.41e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.09 E-value: 2.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 8 LLLAVFCLANLFAgSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLA 87
Cdd:cd17341 1 LHLSWLSFFLGFM-VWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 88 LASCAESLLMLSVVYGLCFGFGvGLTYVSTLGTAMKLFPDRKglAGGLVTMSYGLSSMCVPIAAsnliehfgiTFALLIF 167
Cdd:cd17341 80 ALALAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEK--IGGAAGGIAGAGNMGVAVSQ---------LLAPLIA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 168 GLVCGSVIAAAgiLSGAATSAGVSHEITQALAALRNRPLAASHSTLPVQDKNWKEMLASPVFYAMLVLFICGSTGALMLI 247
Cdd:cd17341 148 GAIVFDGGFVG--WRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 248 PSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTDDVTTFLAGLIL 327
Cdd:cd17341 226 NVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLAL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1821496550 328 tTVCYGSFVGVFPSLtveTFGL--KYNSVNYGIMAAGFSSAGILGPVLLKLFSGASDFSQAYIAAEIVCLAGL 398
Cdd:cd17341 306 -FVALGLGAGAGNGS---VFRMvpFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVL 374
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-287 |
3.14e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.57 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 3 ISRRTLLLAVFCLANLFAG-SLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLM 81
Cdd:COG0477 9 TRRRRRALLALALGTFLEGlDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 82 IGAGLALASCAESLLMLsVVYGLCFGFGVGLTYVSTLGTAMKLFPDRK-GLAGGLVTMSYGLSSMCVPIAASNLIEHFGI 160
Cdd:COG0477 89 FGLASLLCGLAPSPELL-IAARALQGIGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 161 TFALLIFGLVcgSVIAAAGILSGAATSAGVSHEITQALAALRNRPLAASHSTLPVQDKNWKEMLASPVFYAMLVLFICGS 240
Cdd:COG0477 168 RWIFLINAPL--GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1821496550 241 TGALMLIPSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLIS 287
Cdd:COG0477 246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-327 |
3.71e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 45.62 E-value: 3.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 33 LAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVYGLCfGFGVGL 112
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA-GIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 113 TYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFglvcgsviAAAGILSgaatsagvsh 192
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILL--------IIPGLAV---------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 193 eitqALAALRNRPLAASHSTLPVQDKNWKEMLASPVF-YAMLVLFICGSTGALMLIPSAVMISMQQIGLTAQAAAGCVSA 271
Cdd:cd17478 163 ----ALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRaLLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSL 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1821496550 272 LAVANTLGRVSGGLISDRIGRLPTLGVSLFAA--MSGLMLLLCSGTDDVTTFLAGLIL 327
Cdd:cd17478 239 FLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAapFLLLFLLTPGIWSYILLVLAGFLL 296
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
33-181 |
4.02e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.25 E-value: 4.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 33 LAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFG--PKYVLTVGGLMIGAGLALASCAESLLMLsVVYGLCFGFGV 110
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALA-IALLFLAGFGL 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1821496550 111 GLTYVSTLGTAMKLFPDRK-GLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFGLVCGSVIAAAGIL 181
Cdd:COG2271 286 GGAFGLLWALAAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-144 |
4.05e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 4.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 2 LISRRTLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLM 81
Cdd:COG2814 203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821496550 82 IGAGLALASCAESLLMLsVVYGLCFGFGVGLTYVSTLGTAMKLFPDR-KGLAGGLVTMSYGLSS 144
Cdd:COG2814 283 LALGLLLLALAGSLWLL-LLALFLLGFGFGLLFPLLQALVAELAPPEaRGRASGLYNSAFFLGG 345
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
45-170 |
4.19e-05 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 45.60 E-value: 4.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 45 AFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKL 124
Cdd:cd17420 46 AWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHY 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1821496550 125 FPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFGLV 170
Cdd:cd17420 126 FKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYGLEGTLRVLSLF 171
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
62-168 |
7.04e-05 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 44.80 E-value: 7.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 62 GGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYG 141
Cdd:cd17424 58 GSLISNHLSCQVGIILGGLLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSG 137
|
90 100
....*....|....*....|....*..
gi 1821496550 142 LSSMCVPIAASNLIEHFGITFALLIFG 168
Cdd:cd17424 138 IGTFILAPVVQLLIEQFSWRGALLILG 164
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
41-178 |
1.86e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.39 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 41 AADLAFIFsvaAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASC----AESLLMLSVVYGLCFGFGVGLTYVS 116
Cdd:cd17341 243 AGILAALF---PLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLslptSGTNLVLFLALFVALGLGAGAGNGS 319
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1821496550 117 TLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFGLVCGSVIAAA 178
Cdd:cd17341 320 VFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLL 381
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
33-181 |
1.89e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.33 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 33 LAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGP---KYVLTVGGLMIGAGLALASCAESLLMLSVVYGLCFgFG 109
Cdd:cd17319 206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAG-FG 284
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1821496550 110 VGLTYVSTLGTAMKLFPDRK-GLAGGLVTMSYGLSSMCVPIAASNLIEHFGiTFALLIFGLVCGSVIAAAGIL 181
Cdd:cd17319 285 IGAASPVFWSLPADLLPGEAaATAGGLINSGGNLGGFVAPLLIGYLVDATG-SYTAAFLFLAAVALLAALLVL 356
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
33-373 |
2.70e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 42.73 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 33 LAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLsVVYGLCFGFGVGL 112
Cdd:TIGR00895 43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQL-LILRFLAGLGLGG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 113 TYVSTLGTAMKLFPDR-KGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFGLVCGSVI----------AAAGIL 181
Cdd:TIGR00895 122 LMPNLNALVSEYAPKRfRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLlllmrflpesIDFLVS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 182 SGAATSAGVSHEITQALAALRNRPLAASHSTLPVQDKNWKEMLASPVFYAMLVLFICGSTGALM--LIPSAVMISMQQIG 259
Cdd:TIGR00895 202 KRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGvyFLTNWLPKLMVELG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 260 LTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMsgLMLLLCSGTDDVTTFLAGLILTTVCYGSFVGVF 339
Cdd:TIGR00895 282 FSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAV--FAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGL 359
|
330 340 350
....*....|....*....|....*....|....
gi 1821496550 340 PSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVL 373
Cdd:TIGR00895 360 YALMALFYPTAIRATGVGWAIGIGRLGAIIGPIL 393
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
33-182 |
2.89e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 42.95 E-value: 2.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 33 LAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLsVVYGLCFGFGVGL 112
Cdd:cd17473 224 LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVV-LLGAILAGLGFGL 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1821496550 113 TYVSTLGTAMKLFPDRK-GLAGGLVTMSYGLSSMCVPIAASNLI-EHFGITFALLIFGLVCGSVIAAAGILS 182
Cdd:cd17473 303 LLPTLNSWAMSLVPPELrGRAMGIVTSAFFLGQFLSPLVLGPLVnLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
8-170 |
3.66e-04 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 42.51 E-value: 3.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 8 LLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLA 87
Cdd:cd17429 4 VVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSLGWV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 88 LASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIF 167
Cdd:cd17429 84 LSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFIQ 163
|
...
gi 1821496550 168 GLV 170
Cdd:cd17429 164 GAV 166
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
228-403 |
6.05e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 6.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 228 VFYAMLVLFICGSTGALMLIPSAVMIsMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLfaAMSGL 307
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL--LLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 308 MLLLCSGTDDVTTFLAGLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFSGASDFSQAY 387
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170
....*....|....*.
gi 1821496550 388 IAAEIVCLAGLGSLWI 403
Cdd:COG2814 168 LVNAVLALLALLLLLR 183
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
232-403 |
9.03e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 232 MLVLFICGSTGALMLIPSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFaaMSGLMLLL 311
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLL--LFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 312 CSGTDDVTTFLAGLILTTVCYGSFVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFSGASDFSQAYIAAE 391
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|..
gi 1821496550 392 IVCLAGLGSLWI 403
Cdd:pfam07690 159 ILSLLAAVLLLL 170
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
255-404 |
9.29e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.01 E-value: 9.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 255 MQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFaaMSGLMLLLCSGTDDVTTFLAGLILTTVCYGS 334
Cdd:COG2271 37 QADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL--LWGLATLLFGFATSFWQLLLLRFLLGLGEAG 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1821496550 335 FVGVFPSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFSGASDFSQAYIAAEIVCL-AGLGSLWIC 404
Cdd:COG2271 115 FFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLlLALLRFWLL 185
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
6-338 |
1.15e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 40.75 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 6 RTLLLAVFClanlFAGSLYSWSVFS----EPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLM 81
Cdd:TIGR00886 1 RNLFFSWFG----FFLSFLVWFAFSplavFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 82 IGAGLALASCAESLLMLSVVYGLCFGFGvGLTYVSTLGTAMKLFPDRK-----GLAGGLVTMSYGLSSMCVPIAASNLIE 156
Cdd:TIGR00886 77 LAIPCLWAGLAVQSYSVLLLIRLFIGIA-GGSFASCMPWISFFFPKKIqgtalGLAAGWGNMGGGVAQFVMPPIIGSLIF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 157 HFGITfALLIFGLVcgSVIAAAGILSGAATSAGVSheitqALAALRNRPLAASHSTLPVQDknwkeMLASPVFYAMLVLF 236
Cdd:TIGR00886 156 GGGQP-AHLAWGWA--FVIVPAGILLLPALLIFFV-----GADTPPGKPATGKLSFKEALK-----VFGNRHTWILALLY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 237 ICGSTGALMLIPSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTD 316
Cdd:TIGR00886 223 SVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVS 302
|
330 340
....*....|....*....|..
gi 1821496550 317 DVTtfLAGLILTTVCYGSFVGV 338
Cdd:TIGR00886 303 DGS--LAAFIVLFVALFFFAGA 322
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
27-175 |
1.31e-03 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 40.87 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 27 SVFSEPLAQKLSASAADLAFIFSVAA----GINPFAMISggwsNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVY 102
Cdd:cd17430 23 SVFFKELMREFGVGYSDTAWISSILLamlyGTGPLCSIL----VNRFGCRPVMLVGGLLASLGMILASFCTSIIQLYLTA 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1821496550 103 GLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFG------ITFALLIFGLVCGSVI 175
Cdd:cd17430 99 GVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGwrggflILGGLLLNCCTCGAVM 177
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
25-372 |
1.46e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.38 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 25 SWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALAScAESLLMLSVVYGL 104
Cdd:cd17333 14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIF-ATPSIYLFVVLMF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 105 CFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLI-EHFGITFALLIFGLVC-GSVIAAAGILS 182
Cdd:cd17333 93 LAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLIYlLLAILILLTLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 183 GAATSAgvsheitqalaalRNRPLAASHSTLPVQDKNWKEMLASPVFYAMLVLFICGSTGALMlipsaVMISMQQIGLTA 262
Cdd:cd17333 173 PELPSA-------------RNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWV-----PSYLVEKKHVSD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 263 QAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLcsgtddVTTFLAGLILTTVCYGSFVG-VFP- 340
Cdd:cd17333 235 GLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILL------LAPTLVVGLVATALLGLFMAaLFPt 308
|
330 340 350
....*....|....*....|....*....|....
gi 1821496550 341 --SLTVETFGLKYNSVNYGIMAAGFSSAGILGPV 372
Cdd:cd17333 309 ilSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFI 342
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
232-398 |
1.49e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.59 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 232 MLVLFICGSTGALMLIPSAVMIS--MQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTL--GVSLFAAMSGL 307
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTFALSyaTQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYlaGALLAALFAFP 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 308 MLLLCSGTDDVTTFLAGLILTTVCYGSFVGVFPSLTVETFGlkyNSVNYGIMAAGFSSAGILGPVLLKLFS---GASDFS 384
Cdd:cd17369 311 FFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFP---TRVRYTGASLGYQLGAILGGGFAPLIAtalVAATGS 387
|
170
....*....|....
gi 1821496550 385 QAYIAAEIVCLAGL 398
Cdd:cd17369 388 WWPVALYLAALAVI 401
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
18-181 |
1.69e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 18 LFAGSLYSWSVFSEPL----AQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGA---GLALAS 90
Cdd:cd17370 206 LLAVALFALGNFSFAFlilrAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALaylGFALGS 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 91 CAESLLMLSVVYGLCFGF--GVGLTYVSTLgtamkLFPDRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFAlliFG 168
Cdd:cd17370 286 SLWLLLLGFILWGLYMGAqeSIERAAVADL-----VPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAA---FL 357
|
170
....*....|...
gi 1821496550 169 LVCGSVIAAAGIL 181
Cdd:cd17370 358 FSAVLALIALLLL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-403 |
1.93e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 40.25 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 25 SWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVYGL 104
Cdd:cd17319 21 NISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 105 cFGFGVGLTYVSTLGTAMKLFPDR-KGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFGLVcgsviaaaGILSG 183
Cdd:cd17319 101 -LGVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLL--------GLLLA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 184 AATSAGVSHEITQALAALrnrplaashstlpvqdknwkemLASPVFYAMLV---LFICGSTGalmlipsavmISMQQIGL 260
Cdd:cd17319 172 VLWWFYLRQVWGLALGYF----------------------GINYALYGLLTwlpTYLKQARG----------FSLKQVGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 261 TAqaaagcvSALAVANTLGRVSGGLISDRIGRLP-TLGVSLFAAMSGLMLLLCSGTDDVTTFLAGLILTTVCYGSFVGVF 339
Cdd:cd17319 220 LA-------AIPFLAGAIGMILGGRLSDRLLRGArRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVF 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1821496550 340 PSLTVETFGLKYNSVNYGIMAAGFSSAGILGPVLLKLFSGASD-FSQAYIAAEIVCLAGLGSLWI 403
Cdd:cd17319 293 WSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
67-175 |
2.15e-03 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 40.14 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 67 DRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMC 146
Cdd:cd17425 63 ERFGCRVTVMLGGLLSGVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTL 142
|
90 100 110
....*....|....*....|....*....|....*
gi 1821496550 147 VPIAASNLIEHFGITFALLIFG------LVCGSVI 175
Cdd:cd17425 143 WPLLSQYLLEEMGWRGSFLVFGgvllncCVCGAVM 177
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
2-178 |
2.47e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.87 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 2 LISRRTLLLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLM 81
Cdd:cd17320 197 VLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 82 IGAGLALASCAESLLMLS----VVYGLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLV-TMSYGLSSMCVPIAASNlie 156
Cdd:cd17320 277 LLAAALVLLLAALLGGLSlwplVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLgFLQFLIGALAGALVGLL--- 353
|
170 180
....*....|....*....|..
gi 1821496550 157 HFGITFALLIFGLVCGSVIAAA 178
Cdd:cd17320 354 PNGTALPMGLLILVLGLLALLL 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
9-345 |
3.71e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.07 E-value: 3.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 9 LLAVFCLANLFAGSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLAL 88
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 89 ASCAESLLMLsVVYGLCFGFGVGLTYVSTLGTAMKLFP-DRKGLAGGLVTMsyglssmcvpiaasnliehfGITFALlIF 167
Cdd:cd17324 81 AALAPSFALL-LLARALAGLAHGGFWAIAAAYAADLVPpEKRGRAIGLVFS--------------------GLTLGL-VL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 168 GLVCGSVIAAAGILSGAATSAGVSHEITQALAALRNRPLAASHSTLPVQDKNWKEMLASPVFYAMLVLFICGSTGALMLI 247
Cdd:cd17324 139 GRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 248 PSAVMISMQQIGLTAQAAAGCVSALAVANTLGRVSGGLISDRIGRLPTLGVSLFAAMSGLMLLLCSGTddVTTFLAGLIL 327
Cdd:cd17324 219 TYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPS--PLLLLVGLVL 296
|
330
....*....|....*...
gi 1821496550 328 TTVCYGSFVGVFPSLTVE 345
Cdd:cd17324 297 WGLGFFAAHSALQTRVLR 314
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
13-181 |
5.91e-03 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 38.65 E-value: 5.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 13 FCLANLFA-GSLYSWSVFSEPLAQKLSASAADLAFIFSVAAGINPFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASC 91
Cdd:cd17421 8 FFLVNVLVmGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSAGFLISIF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 92 AESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLFPDRKGLAGGLVTMSYGLSSMCVPIAASnLIEHFGITFALLIFGLVC 171
Cdd:cd17421 88 ATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFALAPFTQL-LLDEYDWQGALLIFGGIM 166
|
170
....*....|
gi 1821496550 172 GSVIAAAGIL 181
Cdd:cd17421 167 LNLVASGMLL 176
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
29-170 |
6.72e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 6.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 29 FSEPLAQKLSASAADL---AFIFSVAAGInpFAMISGGWSNDRFGPKYVLTVGGLMIGAGLALASCAESLLMLSVVYgLC 105
Cdd:cd17490 217 FTPLIAKQLGASSFQLgllSIIYLLPNAL--ASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQ-AL 293
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1821496550 106 FGFGVGLTYVSTLGTAMKLFP-DRKGLAGGLVTMSYGLSSMCVPIAASNLIEHFGITFALLIFGLV 170
Cdd:cd17490 294 NGFGTGILFPLLMSLSIEGVPaEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVI 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
9-191 |
7.37e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.31 E-value: 7.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 9 LLAVFCLANLFAGSLYSWSVFSEpLAQKLSASAADLAFIFSVAAGInpFAMISGGWSNDRFGPKYVLTVGGLMIGAGLAL 88
Cdd:cd17321 174 VLAAFLLGAALGGLLFLLPLYLQ-GVLGYSPLQAGLALLPLALAML--VAAPLAGRLADRFGPRLVLVAGLLLTAVGLLL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821496550 89 ASC--AESLLMLSVVYGLCFGFGVGLTYVSTLGTAMKLFP-DRKGLAGGLVTMSYGLSSmCVPIAASNLIEHFGITFALL 165
Cdd:cd17321 251 LALlgADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPkEKAGAASGILNTARQLGG-ALGVALLGALLTAGLSANLG 329
|
170 180
....*....|....*....|....*.
gi 1821496550 166 IFGLVCGSVIAAAGILSGAATSAGVS 191
Cdd:cd17321 330 DSGVAALLSAAAAAFAAGFHLAFLVA 355
|
|
| |
