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Conserved domains on  [gi|1821497888|ref|WP_165648764|]
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MULTISPECIES: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC [Sutterella]

Protein Classification

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase( domain architecture ID 11418829)

bifunctional phosphopantothenoylcysteine decarboxylase (CoaC)/phosphopantothenate synthase (CoaB) catalyzes two steps in the biosynthesis of coenzyme A, the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, followed by its decarboxylation to form 4'-phosphopantotheine

EC:  4.1.1.36|6.3.2.5
Gene Ontology:  GO:0071513|GO:0010181|GO:0046872|GO:0004632|GO:0004633|GO:0015937|GO:0015941

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 1-402 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


:

Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 534.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   1 MLQDKRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPVLTTEWQPGPKGPMPHIDVNRE 80
Cdd:COG0452     1 MLAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  81 SDLLLVMPATANLIAKAARGIADDLASTLICARRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQACGDT 160
Cdd:COG0452    81 ADLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 161 GAGRMLEPAEVVDMMEMVFSPKH-LAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPTHLT 239
Cdd:COG0452   161 GKGRMAEPEEIVEAIEALLAPKKdLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 240 EPVGVKRIDVVSAREMDEAVQIELDRQrfDLFVSVAAVADWRPGGVSEKKIKKdpTGGILlsDLNWVENPDILARVGERP 319
Cdd:COG0452   241 TPAGVERIDVESAEEMLEAVLAAFPDA--DIVIMAAAVADYRPAEVADQKIKK--TDDPL--TLELVKNPDILAELGARK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 320 D-KPLTIGFAAETAEgasLTAFAREKCFRKHAAFIVANDARQA---LESKANCIQLVSLT-SAIPFGPADKFACAQFILT 394
Cdd:COG0452   315 KpGQFLVGFAAETEN---LLENARAKLARKNLDLIVANDVSDAgagFGSDTNAVTLLDKDgREEELPLMSKLEVARRILD 391


                  ....*...
gi 1821497888 395 EAAKQLSG 402
Cdd:COG0452   392 EIAELLAA 399
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 1-402 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 534.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   1 MLQDKRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPVLTTEWQPGPKGPMPHIDVNRE 80
Cdd:COG0452     1 MLAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  81 SDLLLVMPATANLIAKAARGIADDLASTLICARRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQACGDT 160
Cdd:COG0452    81 ADLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 161 GAGRMLEPAEVVDMMEMVFSPKH-LAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPTHLT 239
Cdd:COG0452   161 GKGRMAEPEEIVEAIEALLAPKKdLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 240 EPVGVKRIDVVSAREMDEAVQIELDRQrfDLFVSVAAVADWRPGGVSEKKIKKdpTGGILlsDLNWVENPDILARVGERP 319
Cdd:COG0452   241 TPAGVERIDVESAEEMLEAVLAAFPDA--DIVIMAAAVADYRPAEVADQKIKK--TDDPL--TLELVKNPDILAELGARK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 320 D-KPLTIGFAAETAEgasLTAFAREKCFRKHAAFIVANDARQA---LESKANCIQLVSLT-SAIPFGPADKFACAQFILT 394
Cdd:COG0452   315 KpGQFLVGFAAETEN---LLENARAKLARKNLDLIVANDVSDAgagFGSDTNAVTLLDKDgREEELPLMSKLEVARRILD 391


                  ....*...
gi 1821497888 395 EAAKQLSG 402
Cdd:COG0452   392 EIAELLAA 399
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 1-402 0e+00

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 509.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   1 MLQDKRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPVLTTEWQPGPKGPMPHIDVNRE 80
Cdd:PRK05579    3 MLAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLWDPAAEAAMGHIELAKW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  81 SDLLLVMPATANLIAKAARGIADDLASTLICARRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQACGDT 160
Cdd:PRK05579   83 ADLVLIAPATADLIAKLAHGIADDLLTTTLLATTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPASGRLACGDV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 161 GAGRMLEPAEVVDMMEMVFSPKHLAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPTHLTE 240
Cdd:PRK05579  163 GPGRMAEPEEIVAAAERALSPKDLAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVSGPVNLPT 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 241 PVGVKRIDVVSAREMDEAVQIELdrQRFDLFVSVAAVADWRPGGVSEKKIKKDPTGgillSDLNWVENPDILARVGERPD 320
Cdd:PRK05579  243 PAGVKRIDVESAQEMLDAVLAAL--PQADIFIMAAAVADYRPATVAEGKIKKGEGE----LTLELVPNPDILAEVAALKD 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 321 K-PLTIGFAAETAEgasLTAFAREKCFRKHAAFIVAND--ARQALESKANCIQLV-SLTSAIPFGPADKFACAQFILTEA 396
Cdd:PRK05579  317 KrPFVVGFAAETGD---VLEYARAKLKRKGLDLIVANDvsAGGGFGSDDNEVTLIwSDGGEVKLPLMSKLELARRLLDEI 393


                  ....*.
gi 1821497888 397 AKQLSG 402
Cdd:PRK05579  394 AERLLE 399
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 2-360 4.09e-134

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 390.19  E-value: 4.09e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   2 LQDKRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPVLTTEWQPGPKGPMpHIDVNRES 81
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHNAL-HIDLAKWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  82 DLLLVMPATANLIAKAARGIADDLASTLICARRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQACGDTG 161
Cdd:TIGR00521  80 DLILIAPATANTISKIAHGIADDLVSTTALAASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPRSGLLACGDEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 162 AGRMLEPAEVVDMMEMVFSPK-HLAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPTHLTE 240
Cdd:TIGR00521 160 KGRLAEPETIVKAAEREFSPKeDLEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSLLT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 241 PVGVKRIDVVSAREMDEAVQIELDRQrFDLFVSVAAVADWRPGGVSEKKIKK-DPTGGILLsdlnwVENPDILARVGERP 319
Cdd:TIGR00521 240 PPGVKSIKVSTAEEMLEAALNELAKD-FDIFISAAAVADFKPKTVFEGKIKKqGEELSLKL-----VKNPDIIAEVRKIK 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1821497888 320 DKPLTIGFAAETaeGASLTAFAREKCFRKHAAFIVANDARQ 360
Cdd:TIGR00521 314 KHQVIVGFKAET--NDDLIKYAKEKLKKKNLDMIVANDVSQ 352
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 184-361 1.58e-80

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 245.40  E-value: 1.58e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 184 LAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPTHLTEPVGVKRIDVVSAREMDEAVQIEL 263
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPPPPGVEVVDVESAEEMLEAVLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 264 DRQrfDLFVSVAAVADWRPGGVSEKKIKKDPTGGILlsDLNWVENPDILARVGERPDKPLTIGFAAETAEgasLTAFARE 343
Cdd:pfam04127  81 PEA--DIVIMAAAVADYRPAEVADGKIKKSSGGEEL--TLELVKNPDILAELGKRKPGQLLVGFAAETED---LLENARA 153

                         170
                  ....*....|....*...
gi 1821497888 344 KCFRKHAAFIVANDARQA 361
Cdd:pfam04127 154 KLERKNLDLIVANDVSRP 171
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 1-402 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 534.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   1 MLQDKRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPVLTTEWQPGPKGPMPHIDVNRE 80
Cdd:COG0452     1 MLAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  81 SDLLLVMPATANLIAKAARGIADDLASTLICARRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQACGDT 160
Cdd:COG0452    81 ADLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 161 GAGRMLEPAEVVDMMEMVFSPKH-LAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPTHLT 239
Cdd:COG0452   161 GKGRMAEPEEIVEAIEALLAPKKdLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 240 EPVGVKRIDVVSAREMDEAVQIELDRQrfDLFVSVAAVADWRPGGVSEKKIKKdpTGGILlsDLNWVENPDILARVGERP 319
Cdd:COG0452   241 TPAGVERIDVESAEEMLEAVLAAFPDA--DIVIMAAAVADYRPAEVADQKIKK--TDDPL--TLELVKNPDILAELGARK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 320 D-KPLTIGFAAETAEgasLTAFAREKCFRKHAAFIVANDARQA---LESKANCIQLVSLT-SAIPFGPADKFACAQFILT 394
Cdd:COG0452   315 KpGQFLVGFAAETEN---LLENARAKLARKNLDLIVANDVSDAgagFGSDTNAVTLLDKDgREEELPLMSKLEVARRILD 391


                  ....*...
gi 1821497888 395 EAAKQLSG 402
Cdd:COG0452   392 EIAELLAA 399
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 1-402 0e+00

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 509.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   1 MLQDKRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPVLTTEWQPGPKGPMPHIDVNRE 80
Cdd:PRK05579    3 MLAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLWDPAAEAAMGHIELAKW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  81 SDLLLVMPATANLIAKAARGIADDLASTLICARRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQACGDT 160
Cdd:PRK05579   83 ADLVLIAPATADLIAKLAHGIADDLLTTTLLATTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPASGRLACGDV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 161 GAGRMLEPAEVVDMMEMVFSPKHLAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPTHLTE 240
Cdd:PRK05579  163 GPGRMAEPEEIVAAAERALSPKDLAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVSGPVNLPT 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 241 PVGVKRIDVVSAREMDEAVQIELdrQRFDLFVSVAAVADWRPGGVSEKKIKKDPTGgillSDLNWVENPDILARVGERPD 320
Cdd:PRK05579  243 PAGVKRIDVESAQEMLDAVLAAL--PQADIFIMAAAVADYRPATVAEGKIKKGEGE----LTLELVPNPDILAEVAALKD 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 321 K-PLTIGFAAETAEgasLTAFAREKCFRKHAAFIVAND--ARQALESKANCIQLV-SLTSAIPFGPADKFACAQFILTEA 396
Cdd:PRK05579  317 KrPFVVGFAAETGD---VLEYARAKLKRKGLDLIVANDvsAGGGFGSDDNEVTLIwSDGGEVKLPLMSKLELARRLLDEI 393


                  ....*.
gi 1821497888 397 AKQLSG 402
Cdd:PRK05579  394 AERLLE 399
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 2-360 4.09e-134

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 390.19  E-value: 4.09e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   2 LQDKRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPVLTTEWQPGPKGPMpHIDVNRES 81
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHNAL-HIDLAKWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  82 DLLLVMPATANLIAKAARGIADDLASTLICARRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQACGDTG 161
Cdd:TIGR00521  80 DLILIAPATANTISKIAHGIADDLVSTTALAASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPRSGLLACGDEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 162 AGRMLEPAEVVDMMEMVFSPK-HLAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPTHLTE 240
Cdd:TIGR00521 160 KGRLAEPETIVKAAEREFSPKeDLEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSLLT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 241 PVGVKRIDVVSAREMDEAVQIELDRQrFDLFVSVAAVADWRPGGVSEKKIKK-DPTGGILLsdlnwVENPDILARVGERP 319
Cdd:TIGR00521 240 PPGVKSIKVSTAEEMLEAALNELAKD-FDIFISAAAVADFKPKTVFEGKIKKqGEELSLKL-----VKNPDIIAEVRKIK 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1821497888 320 DKPLTIGFAAETaeGASLTAFAREKCFRKHAAFIVANDARQ 360
Cdd:TIGR00521 314 KHQVIVGFKAET--NDDLIKYAKEKLKKKNLDMIVANDVSQ 352
PRK13982 PRK13982
bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; ...
 5-357 5.48e-126

bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional


Pssm-ID: 172484 [Multi-domain]  Cd Length: 475  Bit Score: 372.55  E-value: 5.48e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   5 KRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPVLTTEWQPGPKGPMPHIDVNRESDLL 84
Cdd:PRK13982   71 KRVTLIIGGGIAAYKALDLIRRLKERGAHVRCVLTKAAQQFVTPLTASALSGQRVYTDLFDPESEFDAGHIRLARDCDLI 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  85 LVMPATANLIAKAARGIADDLASTLICARRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQA-CGDTGAG 163
Cdd:PRK13982  151 VVAPATADLMAKMANGLADDLASAILLAANRPILLAPAMNPLMWNNPATRRNVAQLKRDGVHMIGPNAGEMAeRGEAGVG 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 164 RMLEPAEVVDMMEMVFSPKH---LAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPTHLTE 240
Cdd:PRK13982  231 RMAEPLEIAAAAEALLRPPQpkpLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAAAAGAEVTLISGPVDLAD 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 241 PVGVKRIDVVSAREMDEAVQIELDRqrfDLFVSVAAVADWRPGGVSEKKIKKDPTGgilLSDLNWVENPDILARVGERPD 320
Cdd:PRK13982  311 PQGVKVIHVESARQMLAAVEAALPA---DIAIFAAAVADWRVATEGGQKLKKGAAG---PPPLQLVENPDILATISKLAE 384

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1821497888 321 K--PLTIGFAAETAEgasLTAFAREKCFRKHAAFIVAND 357
Cdd:PRK13982  385 NrpPLVIGFAAETEH---LIDNARAKLARKGCDWIVAND 420
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 184-361 1.58e-80

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 245.40  E-value: 1.58e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 184 LAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPTHLTEPVGVKRIDVVSAREMDEAVQIEL 263
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPPPPGVEVVDVESAEEMLEAVLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 264 DRQrfDLFVSVAAVADWRPGGVSEKKIKKDPTGGILlsDLNWVENPDILARVGERPDKPLTIGFAAETAEgasLTAFARE 343
Cdd:pfam04127  81 PEA--DIVIMAAAVADYRPAEVADGKIKKSSGGEEL--TLELVKNPDILAELGKRKPGQLLVGFAAETED---LLENARA 153

                         170
                  ....*....|....*...
gi 1821497888 344 KCFRKHAAFIVANDARQA 361
Cdd:pfam04127 154 KLERKNLDLIVANDVSRP 171
PRK07313 PRK07313
phosphopantothenoylcysteine decarboxylase; Validated
 5-179 6.04e-68

phosphopantothenoylcysteine decarboxylase; Validated


Pssm-ID: 235986 [Multi-domain]  Cd Length: 182  Bit Score: 213.27  E-value: 6.04e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   5 KRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPVLTTEWQPGPKGPMPHIDVNRESDLL 84
Cdd:PRK07313    2 KNILLAVSGSIAAYKAADLTSQLTKRGYQVTVLMTKAATKFITPLTLQVLSKNPVHLDVMDEHDPKLMNHIELAKRADLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  85 LVMPATANLIAKAARGIADDLAST--LICARRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQACGDTGA 162
Cdd:PRK07313   82 LVAPATANTIAKLAHGIADDLVTSvaLALPATTPKLIAPAMNTKMYENPATQRNLKTLKEDGVQEIEPKEGLLACGDEGY 161

                         170
                  ....*....|....*..
gi 1821497888 163 GRMLEPAEVVDMMEMVF 179
Cdd:PRK07313  162 GALADIETILETIENTL 178
Flavoprotein pfam02441
Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes ...
 5-173 4.33e-42

Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD, which has been shown to be a flavoprotein that binds FMN. This enzyme catalyzes the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance. dipicolinate synthase catalyzes the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase (EC:4.1.1.-).


Pssm-ID: 426775 [Multi-domain]  Cd Length: 177  Bit Score: 146.36  E-value: 4.33e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   5 KRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPVLTTEWQPgPKGPMPHIDV---NRES 81
Cdd:pfam02441   1 KRILVGITGSSAAIKALRLLEELKKEGAEVRVIMTKAAKKVITPETLAALSENVDEDLTWRE-LDDDILHIELasgARWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  82 DLLLVMPATANLIAKAARGIADDLAS----------------TLICARRTPIAFVPAMNAAMWRNPATRRNIEFLRREGa 145
Cdd:pfam02441  80 DAMVIAPASANTLAKIANGIADNLLTraadvalkerrphlenMLTLTAKKPIIIAPAMNTAMYENPATLENLEDLKADG- 158

                         170       180
                  ....*....|....*....|....*...
gi 1821497888 146 lifgpaeglqacgdtGAGRMLEPAEVVD 173
Cdd:pfam02441 159 ---------------GKGRMPEPEAIVG 171
coaC_strep TIGR02113
phosphopantothenoylcysteine decarboxylase, streptococcal; In most bacteria, a single ...
 5-178 1.01e-40

phosphopantothenoylcysteine decarboxylase, streptococcal; In most bacteria, a single bifunctional protein catalyses phosphopantothenoylcysteine decarboxylase and phosphopantothenate--cysteine ligase activities, sequential steps in coenzyme A biosynthesis (see TIGR00521). These activities reside in separate proteins encoded by tandem genes in some bacterial lineages. This model describes proteins from the genera Streptococcus and Enterococcus homologous to the N-terminal region of TIGR00521, corresponding to phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 131168  Cd Length: 177  Bit Score: 142.64  E-value: 1.01e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   5 KRITLIVSGGIAAYKSCETARALMRAGAHVRVVMTEHATKFVTPLTFEALTGSPV-LTTEWQPGPKgPMPHIDVNRESDL 83
Cdd:TIGR02113   1 KKILLAVTGSIAAYKAADLTSQLTKLGYDVTVLMTQAATQFITPLTLQVLSKNPVhLDVMDEHDPK-VINHIELAKKADL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  84 LLVMPATANLIAKAARGIADDLASTLICA--RRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQACGDTG 161
Cdd:TIGR02113  80 FLVAPASANTIAHLAHGFADNIVTSVALAlpPETPKLIAPAMNTKMYQNPITQRNIKILKKIGYQEIQPKESLLACGDYG 159

                         170
                  ....*....|....*..
gi 1821497888 162 AGRMlepAEVVDMMEMV 178
Cdd:TIGR02113 160 RGAL---ADLDDILQTI 173
PLN02496 PLN02496
probable phosphopantothenoylcysteine decarboxylase
 6-169 8.29e-20

probable phosphopantothenoylcysteine decarboxylase


Pssm-ID: 215274  Cd Length: 209  Bit Score: 86.95  E-value: 8.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   6 RITLIVSGGIAAYKSCETARALMRaGAHVRVVMTEHATKFVTPLtfeALTGSPVLTT---EWQPGPK--GPMPHIDVNRE 80
Cdd:PLN02496   21 RILLAASGSVAAIKFGNLCHCFSE-WAEVRAVVTKASLHFIDRA---SLPKDVTLYTdedEWSSWNKigDSVLHIELRRW 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888  81 SDLLLVMPATANLIAKAARGIADDLASTLICA--RRTPIAFVPAMNAAMWRNPATRRNIEFLRREGALIFGPAEGLQACG 158
Cdd:PLN02496   97 ADVMVIAPLSANTLGKIAGGLCDNLLTCIVRAwdYSKPLFVAPAMNTFMWNNPFTERHLMSIDELGISLIPPVTKRLACG 176

                         170
                  ....*....|.
gi 1821497888 159 DTGAGRMLEPA 169
Cdd:PLN02496  177 DYGNGAMAEPS 187
PRK06732 PRK06732
phosphopantothenate--cysteine ligase; Validated
 189-357 1.06e-12

phosphopantothenate--cysteine ligase; Validated


Pssm-ID: 235856 [Multi-domain]  Cd Length: 229  Bit Score: 66.93  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 189 VLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGPT--------HLTepvgVKRIDVVS--AREMDEA 258
Cdd:PRK06732    3 ILITSGGTTEPIDSVRGITNHSTGQLGKIIAETFLAAGHEVTLVTTKTavkpephpNLS----IIEIENVDdlLETLEPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 259 VqieldrQRFDLFVSVAAVADWRPGGVSEKK-----------IKKDPTGGILLSDLNWV-----ENPDILARVGERPDKP 322
Cdd:PRK06732   79 V------KDHDVLIHSMAVSDYTPVYMTDLEevsasdnlnefLTKQNTEAKISSASDYQvlflkKTPKVISYVKKWNPNI 152

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1821497888 323 LTIGFA----AETAEgasLTAFAREKCFRKHAAFIVAND 357
Cdd:PRK06732  153 TLVGFKllvnVSKEE---LIKVARASLIKNQADYILAND 188
spoVFB PRK08305
dipicolinate synthase subunit B; Reviewed
 1-103 7.35e-07

dipicolinate synthase subunit B; Reviewed


Pssm-ID: 181370 [Multi-domain]  Cd Length: 196  Bit Score: 49.51  E-value: 7.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888   1 MLQDKRITLIVSGGIAAY-KSCETARALMRAGAHVRVVMTEHA----TKFVTP----LTFEALTGSPVLTT--EWQP-GP 68
Cdd:PRK08305    2 SLKGKRIGFGLTGSHCTYdEVMPEIEKLVDEGAEVTPIVSYTVqttdTRFGKAeewiKKIEEITGNKVINTivEAEPlGP 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1821497888  69 KGPMphidvnresDLLLVMPATANLIAKAARGIAD 103
Cdd:PRK08305   82 KKLL---------DCMVIAPCTGNTMAKLANAITD 107
PRK09620 PRK09620
hypothetical protein; Provisional
 184-356 9.95e-07

hypothetical protein; Provisional


Pssm-ID: 181997  Cd Length: 229  Bit Score: 49.51  E-value: 9.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 184 LAGKRVLITAGPTYEAIDPVRGITNRSSGLQGFSIARAARDFGAEVTLIAGptHLTE-PVGVKR----IDVVSAREMDEA 258
Cdd:PRK09620    1 MKGKKVLITSGGCLEKWDQVRGHTNMAKGTIGRIIAEELISKGAHVIYLHG--YFAEkPNDINNqlelHPFEGIIDLQDK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821497888 259 VQIELDRQRFDLFVSVAAVADWrpggVSEKKIKKDPT----GGILLSD----LNWVENPDILARVGERPDKPLTIGFAAE 330
Cdd:PRK09620   79 MKSIITHEKVDAVIMAAAGSDW----VVDKICDQEGNvldmNGKISSDiapiIHFQKAPKVLKQIKQWDPETVLVGFKLE 154

                         170       180
                  ....*....|....*....|....*..
gi 1821497888 331 -TAEGASLTAFAREKCFRKHAAFIVAN 356
Cdd:PRK09620  155 sDVNEEELFERAKNRMEEAKASVMIAN 181
AfpA COG1036
Archaeal flavoprotein [Energy production and conversion];
82-107 2.14e-03

Archaeal flavoprotein [Energy production and conversion];


Pssm-ID: 440659 [Multi-domain]  Cd Length: 174  Bit Score: 38.65  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 1821497888  82 DLLLVMPATANLIAKAARGIADDLAS 107
Cdd:COG1036    81 DTLVIAPATSNTVAKIVLGIADTLVT 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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