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Conserved domains on  [gi|1821986506|ref|WP_165726269|]
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MULTISPECIES: GntR family transcriptional regulator [unclassified Pseudoalteromonas]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
16-248 9.38e-77

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 232.06  E-value: 9.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  16 AFQPLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDALFRF 95
Cdd:COG2188     2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  96 FPLQADGKGADL-PKAELLSVELCAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIHQSSDIPHT 174
Cdd:COG2188    82 TSFTEELRARGRePSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGS 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821986506 175 LYHYYQTKFNQTVHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYHYQIEL 248
Cdd:COG2188   162 LYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
16-248 9.38e-77

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 232.06  E-value: 9.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  16 AFQPLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDALFRF 95
Cdd:COG2188     2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  96 FPLQADGKGADL-PKAELLSVELCAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIHQSSDIPHT 174
Cdd:COG2188    82 TSFTEELRARGRePSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGS 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821986506 175 LYHYYQTKFNQTVHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYHYQIEL 248
Cdd:COG2188   162 LYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 108-243 3.08e-30

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 109.61  E-value: 3.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506 108 PKAELLSVELCAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIhQSSDIP-HTLYHYYQTKFNQT 186
Cdd:pfam07702   6 PKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDL-LEEDLEeGSLYDYLEERYGLP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1821986506 187 VHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYH 243
Cdd:pfam07702  85 ITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 108-243 4.47e-30

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 109.31  E-value: 4.47e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  108 PKAELLSVELCAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIHQsSDIPHTLYHYYQTKFNQT- 186
Cdd:smart00866   6 PTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLE-EDLSGSLYEYLEERLGLKi 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1821986506  187 --VHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYH 243
Cdd:smart00866  85 vrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-84 5.20e-25

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 93.67  E-value: 5.20e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1821986506  19 PLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVS 84
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
18-247 5.84e-25

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 98.75  E-value: 5.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  18 QPLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDALF---- 93
Cdd:PRK11402    8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLtvsg 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  94 --RFfpLQADGKgadLPKAELLSVELcAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIHQSSDI 171
Cdd:PRK11402   88 ftDF--GVSQGK---ATKEKVIEQER-VSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821986506 172 PHTLYHYYQTKFN-QTVHKTQdSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYHYQIE 247
Cdd:PRK11402  162 GSSTYQLFQERFDtRVVSDKK-TIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTID 237
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 19-224 2.09e-24

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 97.00  E-value: 2.09e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  19 PLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDALFRF--- 95
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIrni 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  96 -FPLQADGKGAdlpKAELLSVELCAAPVEVIEALQLNkkdkvtklVRRRILDNEFcmsetiylpqsyfpdIHQSSDIPHT 174
Cdd:TIGR02018  81 aDEIVARGHRY---RYELLELETRRATAEDAAALALP--------AGGKVFHSEI---------------VHFENDVPFQ 134

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1821986506 175 LY----------HYYQTKFNQT-----------VHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITES 224
Cdd:TIGR02018 135 LEdrlvnaaavpDYLKQDFTQTtpgaylsqaapLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWS 205
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
16-248 9.38e-77

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 232.06  E-value: 9.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  16 AFQPLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDALFRF 95
Cdd:COG2188     2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  96 FPLQADGKGADL-PKAELLSVELCAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIHQSSDIPHT 174
Cdd:COG2188    82 TSFTEELRARGRePSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGS 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821986506 175 LYHYYQTKFNQTVHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYHYQIEL 248
Cdd:COG2188   162 LYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 108-243 3.08e-30

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 109.61  E-value: 3.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506 108 PKAELLSVELCAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIhQSSDIP-HTLYHYYQTKFNQT 186
Cdd:pfam07702   6 PKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDL-LEEDLEeGSLYDYLEERYGLP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1821986506 187 VHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYH 243
Cdd:pfam07702  85 ITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 108-243 4.47e-30

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 109.31  E-value: 4.47e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  108 PKAELLSVELCAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIHQsSDIPHTLYHYYQTKFNQT- 186
Cdd:smart00866   6 PTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLE-EDLSGSLYEYLEERLGLKi 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1821986506  187 --VHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYH 243
Cdd:smart00866  85 vrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-84 5.20e-25

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 93.67  E-value: 5.20e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1821986506  19 PLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVS 84
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
18-247 5.84e-25

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 98.75  E-value: 5.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  18 QPLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDALF---- 93
Cdd:PRK11402    8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLtvsg 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  94 --RFfpLQADGKgadLPKAELLSVELcAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIHQSSDI 171
Cdd:PRK11402   88 ftDF--GVSQGK---ATKEKVIEQER-VSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821986506 172 PHTLYHYYQTKFN-QTVHKTQdSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYHYQIE 247
Cdd:PRK11402  162 GSSTYQLFQERFDtRVVSDKK-TIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTID 237
PRK09764 PRK09764
GntR family transcriptional regulator;
15-244 6.86e-25

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 98.75  E-value: 6.86e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  15 LAFQPLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDALFR 94
Cdd:PRK09764    1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  95 FFPLQAdgKGADL---PKAELLSVELCAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIHQSSdI 171
Cdd:PRK09764   81 LTSFDE--KLSDRhvdTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQV-M 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1821986506 172 PHTLYHYYQTKFNQTVHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYHY 244
Cdd:PRK09764  158 ENSKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 19-224 2.09e-24

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 97.00  E-value: 2.09e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  19 PLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDALFRF--- 95
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIrni 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  96 -FPLQADGKGAdlpKAELLSVELCAAPVEVIEALQLNkkdkvtklVRRRILDNEFcmsetiylpqsyfpdIHQSSDIPHT 174
Cdd:TIGR02018  81 aDEIVARGHRY---RYELLELETRRATAEDAAALALP--------AGGKVFHSEI---------------VHFENDVPFQ 134

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1821986506 175 LY----------HYYQTKFNQT-----------VHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITES 224
Cdd:TIGR02018 135 LEdrlvnaaavpDYLKQDFTQTtpgaylsqaapLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWS 205
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 7-247 5.32e-24

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 96.39  E-value: 5.32e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506   7 DHKLSGPSLafqplYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQH 86
Cdd:TIGR02325   1 IERTSGVAL-----WRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAAR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  87 TAQDAL---FRFfpLQADGKGADLPKAELLSVELCAAPVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFP 163
Cdd:TIGR02325  76 RIDYPLsarTRF--SQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFP 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506 164 DIHQSSDIPHTLYHYYQTKFNQTVHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYH 243
Cdd:TIGR02325 154 GIGQAYAASGSITDALREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVE 233


                  ....
gi 1821986506 244 YQIE 247
Cdd:TIGR02325 234 FTME 237
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 20-83 2.31e-22

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 86.90  E-value: 2.31e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821986506  20 LYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFV 83
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
18-129 2.38e-20

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 86.14  E-value: 2.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  18 QPLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQhTAQDALFRFFP 97
Cdd:COG2186     6 RSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRE-PSPWALLDPLA 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1821986506  98 LQADGKGADLpkAELLSV---------ELCA--APVEVIEALQ 129
Cdd:COG2186    85 LLLALDDASL--RDLLEArlalepeaaRLAAerATDEDLARLE 125
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
18-113 1.61e-19

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 80.99  E-value: 1.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  18 QPLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVS-----------QH 86
Cdd:COG1725     9 VPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAedarelleerrEE 88

                          90       100
                  ....*....|....*....|....*..
gi 1821986506  87 TAQDALFRFFplqADGKGADLPKAELL 113
Cdd:COG1725    89 FLEEALRELV---AEARRLGLSLEELL 112
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 18-92 2.32e-19

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 86.42  E-value: 2.32e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1821986506  18 QPLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDAL 92
Cdd:COG1167    11 GPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAP 85
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
24-83 8.96e-19

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 77.23  E-value: 8.96e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506   24 VADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFV 83
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 21-244 3.36e-18

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 80.49  E-value: 3.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  21 YLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQD----ALFRFF 96
Cdd:TIGR02404   2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEfpisGITSFK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  97 PLQAD-GKGAdlpKAELLSVELCA-APVEVIEALQLNKKDKVTKLVRRRILDNEFCMSETIYLPQSYFPDIHQSSdIPHT 174
Cdd:TIGR02404  82 ELNETlGLDS---KTEVVELDKEDpLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEI-AEDS 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506 175 LYHYYQTKFNQTVHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRITESIEGKRIEYRQSKCRSDHYHY 244
Cdd:TIGR02404 158 IYQYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKF 227
PRK14999 PRK14999
histidine utilization repressor; Provisional
 13-224 4.85e-16

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 74.97  E-value: 4.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  13 PSLAFQPLYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDAL 92
Cdd:PRK14999    6 SRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  93 FRFFPLqADGKGA--DLPKAELLSVELCAAPVEVIEALQLNKKDKVTKLVRRRiLDNEF-------CMSETI---YLPQS 160
Cdd:PRK14999   86 FEVRSI-AEEIAArrHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVH-YENDLpvqiedrCVNADIavdYLTQD 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821986506 161 YfpdihqSSDIPHTlYHYYQTKFNQTVHktqdSIKAVLATVDDAKMLAIKAGDPLLLVSRITES 224
Cdd:PRK14999  164 Y------RQTTPHA-YLSRIAPLTEGEH----IVEAVRATAQECAWLTIKEHEPCLLIRRTTWS 216
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 10-247 5.20e-15

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 72.11  E-value: 5.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  10 LSGPSLAFQPLYLQVADYIKQLIVERrWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVsqhtaq 89
Cdd:PRK10079    3 LSRHPTSYPTRYQEIAAKLEQELRQH-YRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV------ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  90 daLFRFF--PLQADGK--------GADlPKAELLSVELCAAPVEVIEALQLNKKDKVTKL-VRRRILDNEFCMSETiYLP 158
Cdd:PRK10079   76 --LMRPYdyPLNAQARfsqnlldqGSH-PTSEKLLSVLRPASGHVADALGITEGENVIHLrTLRRVNGVALCLIDH-YFA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506 159 Q-SYFPDIHQSSDipHTLYHYYQTKFNQTVHKTQDSIKAVLATVDDAKMLAIKAGDPLLLVSRI-TESIEGKRIEYRQSK 236
Cdd:PRK10079  152 DlTWWPTLQRFDS--GSLHDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTLnHRDGESSPAEYSVSL 229

                         250
                  ....*....|.
gi 1821986506 237 CRSDHYHYQIE 247
Cdd:PRK10079  230 TRADMIEFTME 240
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
18-92 5.64e-13

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 66.10  E-value: 5.64e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1821986506  18 QPLYLQVADYIKQLIVERRWVPGEALpSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDAL 92
Cdd:COG1802    10 ESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIR 83
PRK10225 PRK10225
Uxu operon transcriptional regulator;
21-130 2.89e-11

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 61.57  E-value: 2.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  21 YLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDALfrffplqa 100
Cdd:PRK10225   11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNT-------- 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1821986506 101 dgKGADlpkaellsVELC--AAPVEVIEALQL 130
Cdd:PRK10225   83 --DSPD--------ANVCndAGPFELLQARQL 104
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
28-114 4.80e-10

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 58.11  E-value: 4.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  28 IKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVsqhtaQDALFRFFplqADgkgadl 107
Cdd:PRK09464   19 LEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV-----QSSLWQSF---SD------ 84


                  ....*..
gi 1821986506 108 PKAELLS 114
Cdd:PRK09464   85 PLVELLS 91
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 23-92 1.12e-09

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 57.08  E-value: 1.12e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  23 QVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQDAL 92
Cdd:PRK09990   11 VVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDA 80
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 23-89 3.41e-09

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 55.54  E-value: 3.41e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821986506  23 QVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAQ 89
Cdd:PRK10421    6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHET 72
PRK11523 PRK11523
transcriptional regulator ExuR;
20-83 5.69e-06

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 46.38  E-value: 5.69e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821986506  20 LYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFV 83
Cdd:PRK11523    9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
HTH_41 pfam14502
Helix-turn-helix domain;
40-83 9.02e-06

Helix-turn-helix domain;


Pssm-ID: 433997 [Multi-domain]  Cd Length: 48  Bit Score: 42.09  E-value: 9.02e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1821986506  40 GEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVT--RRQGVGTFV 83
Cdd:pfam14502   3 GERLPTISEYSHKFELSVGTVQKALKKLEDMKAIQleRRGHNGTYL 48
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 12-94 1.23e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 45.01  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  12 GPSLAFQP-----LYLQVADYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQH 86
Cdd:PRK03837    1 GRNLRSRPiarkkLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRP 80


                  ....*...
gi 1821986506  87 TAqDALFR 94
Cdd:PRK03837   81 SA-DTIIG 87
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 26-114 1.49e-05

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 45.42  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821986506  26 DYIKQLIVERRWVPGEALPSEFRLAEEFNVSQGTVRKALNLLTDNKIVTRRQGVGTFVSQHTAqdalfrffPLQADGKGA 105
Cdd:PRK15481   12 DSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPS--------PVALEGGDP 83


                  ....*....
gi 1821986506 106 DLPKAELLS 114
Cdd:PRK15481   84 GTPLHDLAG 92
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
49-84 7.64e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.11  E-value: 7.64e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1821986506   49 LAEEFNVSQGTVRKALNLLTDNKIV-TRRQGVGTFVS 84
Cdd:smart00418  16 LAEILGLSQSTVSHHLKKLREAGLVeSRREGKRVYYS 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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