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Conserved domains on  [gi|1822009937|ref|WP_165744405|]
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MULTISPECIES: ATP-binding protein [unclassified Pseudoalteromonas]

Protein Classification

ATP-binding protein( domain architecture ID 10439784)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18208389|17897320|18466635|16072036|11916378|15037233
SCOP:  2000039

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 53-191 2.44e-20

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


:

Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 84.18  E-value: 2.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLqcdDFKYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSeneeKVFLHFDDVDAVLCSR 132
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKEL---GAPFIEISGSELVSKYVGESEKRLRELFEAAKKLA----PCVIFIDEIDALAGSR 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1822009937 133 YiSNESSGVKRLVNTFIKEIDRIQSKKYKFTpIITTTTNMFsLIDTAVKRRFSIKLPIE 191
Cdd:pfam00004  74 G-SGGDSESRRVVNQLLTELDGFTSSNSKVI-VIAATNRPD-KLDPALLGRFDRIIEFP 129
 
Name Accession Description Interval E-value
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 53-191 2.44e-20

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 84.18  E-value: 2.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLqcdDFKYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSeneeKVFLHFDDVDAVLCSR 132
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKEL---GAPFIEISGSELVSKYVGESEKRLRELFEAAKKLA----PCVIFIDEIDALAGSR 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1822009937 133 YiSNESSGVKRLVNTFIKEIDRIQSKKYKFTpIITTTTNMFsLIDTAVKRRFSIKLPIE 191
Cdd:pfam00004  74 G-SGGDSESRRVVNQLLTELDGFTSSNSKVI-VIAATNRPD-KLDPALLGRFDRIIEFP 129
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
41-191 2.38e-19

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 84.55  E-value: 2.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  41 EHKR--ELYKFNP----TIMLYGSPGTGKTTLLKNVS--LGLQcddfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEess 112
Cdd:COG1223    20 ELRRreNLRKFGLwpprKILFYGPPGTGKTMLAEALAgeLKLP-----LLTVRLDSLIGSYLGETARNLRKLFDFAR--- 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1822009937 113 enEEKVFLHFDDVDAVLCSRYISNESSGVKRLVNTFIKEIDRIQSKKykftpIITTTTNMFSLIDTAVKRRFSIKLPIE 191
Cdd:COG1223    92 --RAPCVIFFDEFDAIAKDRGDQNDVGEVKRVVNALLQELDGLPSGS-----VVIAATNHPELLDSALWRRFDEVIEFP 163
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 25-190 5.65e-18

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 78.86  E-value: 5.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  25 YDKLLKFCQLVWSNDWEHKRELyKFNPTIMLYGSPGTGKTTLLKNV--SLGLqcddfKYFSLSLELLLDKDLGKSSQQLK 102
Cdd:cd19481     2 KASLREAVEAPRRGSRLRRYGL-GLPKGILLYGPPGTGKTLLAKALagELGL-----PLIVVKLSSLLSKYVGESEKNLR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937 103 LFFEQVEESSeneeKVFLHFDDVDAVLCSRYISNESSGVKRLVNTFIKEIDRIQSKKykftPIIT-TTTNMFSLIDTAVK 181
Cdd:cd19481    76 KIFERARRLA----PCILFIDEIDAIGRKRDSSGESGELRRVLNQLLTELDGVNSRS----KVLViAATNRPDLLDPALL 147

                         170
                  ....*....|.
gi 1822009937 182 R--RFSIKLPI 190
Cdd:cd19481   148 RpgRFDEVIEF 158
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 50-192 4.26e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 54.30  E-value: 4.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937   50 NPTIMLYGSPGTGKTTLLKNVSLGLQCDDFKYFSLSLELLLDKDL--------------GKSSQQLKLFFEQVEESSene 115
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLdqllliivggkkasGSGELRLRLALALARKLK--- 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1822009937  116 EKVFLhFDDVDAVLcsryisneSSGVKRLVNTFIKEIDRIQSKKYKFTPIITTTTNMFSLIDTAVKRRFSIKLPIEN 192
Cdd:smart00382  79 PDVLI-LDEITSLL--------DAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLL 146
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 53-182 5.08e-08

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 53.76  E-value: 5.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLQCDdfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSeneeKVFLHFDDVDAVLCSR 132
Cdd:TIGR01243 490 VLLFGPPGTGKTLLAKAVATESGAN---FIAVRGPEILSKWVGESEKAIREIFRKARQAA----PAIIFFDEIDAIAPAR 562

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1822009937 133 YISNESSGVKRLVNTFIKEIDRIQSKKykfTPIITTTTNMFSLIDTAVKR 182
Cdd:TIGR01243 563 GARFDTSVTDRIVNQLLTEMDGIQELS---NVVVIAATNRPDILDPALLR 609
 
Name Accession Description Interval E-value
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 53-191 2.44e-20

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 84.18  E-value: 2.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLqcdDFKYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSeneeKVFLHFDDVDAVLCSR 132
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKEL---GAPFIEISGSELVSKYVGESEKRLRELFEAAKKLA----PCVIFIDEIDALAGSR 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1822009937 133 YiSNESSGVKRLVNTFIKEIDRIQSKKYKFTpIITTTTNMFsLIDTAVKRRFSIKLPIE 191
Cdd:pfam00004  74 G-SGGDSESRRVVNQLLTELDGFTSSNSKVI-VIAATNRPD-KLDPALLGRFDRIIEFP 129
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
41-191 2.38e-19

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 84.55  E-value: 2.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  41 EHKR--ELYKFNP----TIMLYGSPGTGKTTLLKNVS--LGLQcddfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEess 112
Cdd:COG1223    20 ELRRreNLRKFGLwpprKILFYGPPGTGKTMLAEALAgeLKLP-----LLTVRLDSLIGSYLGETARNLRKLFDFAR--- 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1822009937 113 enEEKVFLHFDDVDAVLCSRYISNESSGVKRLVNTFIKEIDRIQSKKykftpIITTTTNMFSLIDTAVKRRFSIKLPIE 191
Cdd:COG1223    92 --RAPCVIFFDEFDAIAKDRGDQNDVGEVKRVVNALLQELDGLPSGS-----VVIAATNHPELLDSALWRRFDEVIEFP 163
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 44-191 3.07e-18

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 83.81  E-value: 3.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  44 RELYKFNPT--IMLYGSPGTGKTTLLKNVS--LGLQcddfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSEneekVF 119
Cdd:COG0464   183 REEYGLPPPrgLLLYGPPGTGKTLLARALAgeLGLP-----LIEVDLSDLVSKYVGETEKNLREVFDKARGLAP----CV 253

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1822009937 120 LHFDDVDAVLCSRyiSNESSGV-KRLVNTFIKEIDRIQSKkykfTPIITTTtNMFSLIDTAVKRRFSIKLPIE 191
Cdd:COG0464   254 LFIDEADALAGKR--GEVGDGVgRRVVNTLLTEMEELRSD----VVVIAAT-NRPDLLDPALLRRFDEIIFFP 319
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 25-190 5.65e-18

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 78.86  E-value: 5.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  25 YDKLLKFCQLVWSNDWEHKRELyKFNPTIMLYGSPGTGKTTLLKNV--SLGLqcddfKYFSLSLELLLDKDLGKSSQQLK 102
Cdd:cd19481     2 KASLREAVEAPRRGSRLRRYGL-GLPKGILLYGPPGTGKTLLAKALagELGL-----PLIVVKLSSLLSKYVGESEKNLR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937 103 LFFEQVEESSeneeKVFLHFDDVDAVLCSRYISNESSGVKRLVNTFIKEIDRIQSKKykftPIIT-TTTNMFSLIDTAVK 181
Cdd:cd19481    76 KIFERARRLA----PCILFIDEIDAIGRKRDSSGESGELRRVLNQLLTELDGVNSRS----KVLViAATNRPDLLDPALL 147

                         170
                  ....*....|.
gi 1822009937 182 R--RFSIKLPI 190
Cdd:cd19481   148 RpgRFDEVIEF 158
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 53-221 2.29e-16

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 77.74  E-value: 2.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNV--SLGLQcddfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSeneeKVFLHFDDVDAVLC 130
Cdd:COG1222   115 VLLYGPPGTGKTLLAKAVagELGAP-----FIRVRGSELVSKYIGEGARNVREVFELAREKA----PSIIFIDEIDAIAA 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937 131 SRYISNESSGVKRLVNTFIKEIDRIQSKKykfTPIITTTTNMFSLIDTAVKR--RFSIKLPIENNiNVEDFKCWLKPIFS 208
Cdd:COG1222   186 RRTDDGTSGEVQRTVNQLLAELDGFESRG---DVLIIAATNRPDLLDPALLRpgRFDRVIEVPLP-DEEAREEILKIHLR 261

                         170
                  ....*....|...
gi 1822009937 209 DLEIVGNIDYVEL 221
Cdd:COG1222   262 DMPLADDVDLDKL 274
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 45-190 1.48e-12

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 64.30  E-value: 1.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  45 ELYKFNPT----IMLYGSPGTGKTTLLKNVSlgLQCDDfKYFSLSLELLLDKDLGKSSQQLKLFFEQveeSSENEEKVFL 120
Cdd:cd19509    23 DLFPGLRGpprgILLYGPPGTGKTLLARAVA--SESGS-TFFSISASSLVSKWVGESEKIVRALFAL---ARELQPSIIF 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937 121 hFDDVDAvLCSRYISNESSGVKRLVNTFIKEIDRIQSKKYKFTPIItTTTNMFSLIDTAVKRRFSIKLPI 190
Cdd:cd19509    97 -IDEIDS-LLSERGSGEHEASRRVKTEFLVQMDGVLNKPEDRVLVL-GATNRPWELDEAFLRRFEKRIYI 163
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 53-184 2.52e-12

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 63.46  E-value: 2.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLQCDdfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSENeekvFLHFDDVDAVLCSR 132
Cdd:cd19511    30 VLLYGPPGCGKTLLAKALASEAGLN---FISVKGPELFSKYVGESERAVREIFQKARQAAPC----IIFFDEIDSLAPRR 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1822009937 133 YISNESSGVKRLVNTFIKEIDRIQSKKYKFtpiITTTTNMFSLIDTAVKR--RF 184
Cdd:cd19511   103 GQSDSSGVTDRVVSQLLTELDGIESLKGVV---VIAATNRPDMIDPALLRpgRL 153
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 50-190 2.95e-12

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 64.00  E-value: 2.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  50 NPTIMLYGSPGTGKTTLLKNVS--LGLQCDDFKYFSLSLEL----LLDKDLGKSSQQLKLFFEQVEESSENEEK-VFLHF 122
Cdd:cd19508    52 NRLVLLHGPPGTGKTSLCKALAqkLSIRLSSRYRYGQLIEInshsLFSKWFSESGKLVTKMFQKIQELIDDKDAlVFVLI 131

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1822009937 123 DDVDAVLCSRYIS---NESSGVKRLVNTFIKEIDRIqsKKYKFTPIITTTTNMFSlIDTAVKRRFSIKLPI 190
Cdd:cd19508   132 DEVESLAAARSASssgTEPSDAIRVVNAVLTQIDRI--KRYHNNVILLTSNLLEK-IDVAFVDRADIKQYI 199
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 29-190 3.27e-11

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 60.65  E-value: 3.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  29 LKFCQLvwsndWEHKRELYKfnpTIMLYGSPGTGKTTLLKNVSLGLqcdDFKYFSLSLELLLDKDLGKSSQQLKLFFEQV 108
Cdd:cd19521    27 VKFPHL-----FTGNRKPWS---GILLYGPPGTGKSYLAKAVATEA---NSTFFSVSSSDLVSKWMGESEKLVKQLFAMA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937 109 EESseNEEKVFLhfDDVDAvLCSRYISNESSGVKRLVNTFIKEIDRIQSKKYKFtpIITTTTNMFSLIDTAVKRRFSIKL 188
Cdd:cd19521    96 REN--KPSIIFI--DEVDS-LCGTRGEGESEASRRIKTELLVQMNGVGNDSQGV--LVLGATNIPWQLDSAIRRRFEKRI 168


                  ..
gi 1822009937 189 PI 190
Cdd:cd19521   169 YI 170
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 53-182 7.00e-11

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 59.42  E-value: 7.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLQCDdfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSeneeKVFLHFDDVDAvLCSR 132
Cdd:cd19530    33 VLLYGPPGCGKTLLAKAVANESGAN---FISVKGPELLNKYVGESERAVRQVFQRARASA----PCVIFFDEVDA-LVPK 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1822009937 133 YISNESSGVKRLVNTFIKEIDRIQSKKYKFtpiITTTTNMFSLIDTAVKR 182
Cdd:cd19530   105 RGDGGSWASERVVNQLLTEMDGLEERSNVF---VIAATNRPDIIDPAMLR 151
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 19-191 1.24e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 58.70  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  19 YGLNNEYDKLLkfcQLVWSNDWEHkrelykfnptIMLYGSPGTGKTTLLKNVSLGLQCDDFKYFSLSLELLLDKDLGKSS 98
Cdd:cd00009     1 VGQEEAIEALR---EALELPPPKN----------LLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAEL 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  99 QQLKLFFEQVEESSENEEKVFLhFDDVDAVLcsryiSNESSGVKRLVNTFIKEIDRIQskkyKFTPIITTTTNMFSLIDT 178
Cdd:cd00009    68 FGHFLVRLLFELAEKAKPGVLF-IDEIDSLS-----RGAQNALLRVLETLNDLRIDRE----NVRVIGATNRPLLGDLDR 137

                         170
                  ....*....|...
gi 1822009937 179 AVKRRFSIKLPIE 191
Cdd:cd00009   138 ALYDRLDIRIVIP 150
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 41-182 5.63e-10

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 56.75  E-value: 5.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  41 EHKRELYKFNPT----IMLYGSPGTGKTTLLKNVSLGLQCDdfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSenee 116
Cdd:cd19528    14 EHPDKFLKFGMTpskgVLFYGPPGCGKTLLAKAIANECQAN---FISVKGPELLTMWFGESEANVRDIFDKARAAA---- 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1822009937 117 KVFLHFDDVDAVLCSR--YISNESSGVKRLVNTFIKEIDRIQSKKYKFtpiITTTTNMFSLIDTAVKR 182
Cdd:cd19528    87 PCVLFFDELDSIAKARggNIGDAGGAADRVINQILTEMDGMNTKKNVF---IIGATNRPDIIDPAILR 151
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 53-190 1.45e-09

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 55.96  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLQCDDFKYfsLSLELLLDKDLGKSSQQL-KLFFEQVEESSENEEKVFLH---FDDVDAV 128
Cdd:cd19504    38 ILLYGPPGTGKTLMARQIGKMLNAREPKI--VNGPEILNKYVGESEANIrKLFADAEEEQRRLGANSGLHiiiFDEIDAI 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1822009937 129 LCSRYISNESSGV-KRLVNTFIKEIDRIQSKKykfTPIITTTTNMFSLIDTAVKR--RFSIKLPI 190
Cdd:cd19504   116 CKQRGSMAGSTGVhDTVVNQLLSKIDGVEQLN---NILVIGMTNRKDLIDEALLRpgRLEVQMEI 177
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 50-192 4.26e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 54.30  E-value: 4.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937   50 NPTIMLYGSPGTGKTTLLKNVSLGLQCDDFKYFSLSLELLLDKDL--------------GKSSQQLKLFFEQVEESSene 115
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLdqllliivggkkasGSGELRLRLALALARKLK--- 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1822009937  116 EKVFLhFDDVDAVLcsryisneSSGVKRLVNTFIKEIDRIQSKKYKFTPIITTTTNMFSLIDTAVKRRFSIKLPIEN 192
Cdd:smart00382  79 PDVLI-LDEITSLL--------DAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLL 146
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 53-182 1.40e-08

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 52.82  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSlgLQCdDFKYFSLSLELLLDKDLGKSSQQLKLFFEQVEESseneEKVFLHFDDVDAVLCSR 132
Cdd:cd19526    30 ILLYGPPGCGKTLLASAIA--SEC-GLNFISVKGPELLNKYIGASEQNVRDLFSRAQSA----KPCILFFDEFDSIAPKR 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1822009937 133 yiSNESSGVK-RLVNTFIKEIDRIQSKKYKFtpiITTTTNMFSLIDTAVKR 182
Cdd:cd19526   103 --GHDSTGVTdRVVNQLLTQLDGVEGLDGVY---VLAATSRPDLIDPALLR 148
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 53-184 3.18e-08

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 51.74  E-value: 3.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSlgLQCdDFKYFSLSLELLLDKDLGKSSQQLKLFFEQVEESseneEKVFLHFDDVDAVLCSR 132
Cdd:cd19527    29 ILLYGPPGTGKTLLAKAIA--TEC-SLNFLSVKGPELINMYIGESEANVREVFQKARDA----KPCVIFFDELDSLAPSR 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1822009937 133 YISNESSGV-KRLVNTFIKEIDRIQSKKYKFtpIITTTTNMFSLIDTAVKR--RF 184
Cdd:cd19527   102 GNSGDSGGVmDRVVSQLLAELDGMSSSGQDV--FVIGATNRPDLLDPALLRpgRF 154
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 53-185 3.92e-08

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 51.77  E-value: 3.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLQCddfKYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSENeekvFLHFDDVDAVLCSR 132
Cdd:cd19524    36 LLLFGPPGNGKTMLAKAVAAESNA---TFFNISAASLTSKYVGEGEKLVRALFAVARELQPS----IIFIDEVDSLLSER 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1822009937 133 YiSNESSGVKRLVNTFIKEIDRIQSKKYKFTpIITTTTNMFSLIDTAVKRRFS 185
Cdd:cd19524   109 S-EGEHEASRRLKTEFLIEFDGVQSNGDDRV-LVMGATNRPQELDDAVLRRFT 159
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 53-182 5.08e-08

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 53.76  E-value: 5.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLQCDdfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSeneeKVFLHFDDVDAVLCSR 132
Cdd:TIGR01243 490 VLLFGPPGTGKTLLAKAVATESGAN---FIAVRGPEILSKWVGESEKAIREIFRKARQAA----PAIIFFDEIDAIAPAR 562

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1822009937 133 YISNESSGVKRLVNTFIKEIDRIQSKKykfTPIITTTTNMFSLIDTAVKR 182
Cdd:TIGR01243 563 GARFDTSVTDRIVNQLLTEMDGIQELS---NVVVIAATNRPDILDPALLR 609
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 53-190 1.28e-07

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 50.37  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSlgLQCDDfKYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSENeeKVFLhfDDVDAVLCSR 132
Cdd:cd19522    36 VLMVGPPGTGKTLLAKAVA--TECGT-TFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPT--TIFI--DEIDSICSRR 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1822009937 133 YISNESSGVKRLVNTFIKEIDRIQSKKYKFTP----IITTTTNMFSLIDTAVKRRFSIKLPI 190
Cdd:cd19522   109 GTSEEHEASRRVKSELLVQMDGVGGASENDDPskmvMVLAATNFPWDIDEALRRRLEKRIYI 170
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 20-190 2.00e-07

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 49.60  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  20 GLNNEYDKLLKFCQLVWsndweHKRELYKF---NPT--IMLYGSPGTGKTTLLKNV--SLGLQcddfkYFSLSLELLLDK 92
Cdd:cd19503     4 GLDEQIASLKELIELPL-----KYPELFRAlglKPPrgVLLHGPPGTGKTLLARAVanEAGAN-----FLSISGPSIVSK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  93 DLGKSSQQLKLFFeqvEESSENEEKVfLHFDDVDAvLCSRYISNESSGVKRLVNTFIKEIDRIQSKKykfTPIITTTTNM 172
Cdd:cd19503    74 YLGESEKNLREIF---EEARSHAPSI-IFIDEIDA-LAPKREEDQREVERRVVAQLLTLMDGMSSRG---KVVVIAATNR 145

                         170       180
                  ....*....|....*....|
gi 1822009937 173 FSLIDTAVKR--RFSIKLPI 190
Cdd:cd19503   146 PDAIDPALRRpgRFDREVEI 165
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 53-182 3.05e-07

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 49.03  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLQCDdfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSeneeKVFLHFDDVDAVLCSR 132
Cdd:cd19529    30 ILLYGPPGTGKTLLAKAVATESNAN---FISVKGPELLSKWVGESEKAIREIFRKARQVA----PCVIFFDEIDSIAPRR 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1822009937 133 YISNESSGVKRLVNTFIKEIDRIQSKKykfTPIITTTTNMFSLIDTAVKR 182
Cdd:cd19529   103 GTTGDSGVTERVVNQLLTELDGLEEMN---GVVVIAATNRPDIIDPALLR 149
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 53-190 1.12e-06

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 48.06  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSlgLQCDDfKYFSLSLELLLDKDLGKSSQQLKLFFeqveESSENEEKVFLHFDDVDAVLCSR 132
Cdd:cd19525    58 ILLFGPPGTGKTLIGKCIA--SQSGA-TFFSISASSLTSKWVGEGEKMVRALF----SVARCKQPAVIFIDEIDSLLSQR 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1822009937 133 YISNESSGvKRLVNTFIKEIDRIQSKKYKFTpIITTTTNMFSLIDTAVKRRFSIKLPI 190
Cdd:cd19525   131 GEGEHESS-RRIKTEFLVQLDGATTSSEDRI-LVVGATNRPQEIDEAARRRLVKRLYI 186
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 53-190 1.15e-06

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 47.43  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSlgLQCDDFkYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSENeekvFLHFDDVDAVLCSR 132
Cdd:cd19519    37 ILLYGPPGTGKTLIARAVA--NETGAF-FFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA----IIFIDEIDAIAPKR 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1822009937 133 yisNESSG--VKRLVNTFIKEIDRIQSKKYKftpIITTTTNMFSLIDTAVKR--RFSIKLPI 190
Cdd:cd19519   110 ---EKTHGevERRIVSQLLTLMDGLKQRAHV---IVMAATNRPNSIDPALRRfgRFDREIDI 165
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 53-184 2.49e-06

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 48.36  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLQCDdfkYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSENeekvFLHFDDVDAVLCSR 132
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEAGAY---FISINGPEIMSKYYGESEERLREIFKEAEENAPS----IIFIDEIDAIAPKR 287

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1822009937 133 yisNESSG--VKRLVNTFIKEIDRIqskKYKFTPIITTTTNMFSLIDTAVKR--RF 184
Cdd:TIGR01243 288 ---EEVTGevEKRVVAQLLTLMDGL---KGRGRVIVIGATNRPDALDPALRRpgRF 337
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 43-183 3.04e-05

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 43.57  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  43 KRELYKFNPT------IMLYGSPGTGKTTLLKNVSLGLQCddfKYFSLSLELLLDKDLGKSSQQLKLFFEQVEESseneE 116
Cdd:cd19520    22 RPELFDNSRLlqppkgVLLYGPPGCGKTMLAKATAKEAGA---RFINLQVSSLTDKWYGESQKLVAAVFSLASKL----Q 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1822009937 117 KVFLHFDDVDAVLCSRYiSNESSGVKRLVNTFIKEIDRIqSKKYKFTPIITTTTNMFSLIDTAVKRR 183
Cdd:cd19520    95 PSIIFIDEIDSFLRQRS-STDHEATAMMKAEFMSLWDGL-STDGNCRVIVMGATNRPQDLDEAILRR 159
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 53-184 3.85e-05

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 43.09  E-value: 3.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  53 IMLYGSPGTGKTTLLKNVSLGLQCddfKYFSLSLELLLDKDLGKSSQQLKLFFEQVEESSENeekvFLHFDDVDAVLCSR 132
Cdd:cd19502    40 VLLYGPPGTGKTLLAKAVANHTDA---TFIRVVGSELVQKYIGEGARLVRELFEMAREKAPS----IIFIDEIDAIGAKR 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1822009937 133 YISNES--SGVKRLVNTFIKEIDRIQSKK-YKftpiITTTTNMFSLIDTAVKR--RF 184
Cdd:cd19502   113 FDSGTGgdREVQRTMLELLNQLDGFDPRGnIK----VIMATNRPDILDPALLRpgRF 165
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 47-184 8.07e-05

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 42.11  E-value: 8.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  47 YKFNPT--IMLYGSPGTGKTTLLKNVSLGLQCDDFK--YFSLSLELLLDKDLGKSSQQLKLFFEQVEESSENeekvFLHF 122
Cdd:cd19517    29 FKITPPrgVLFHGPPGTGKTLMARALAAECSKGGQKvsFFMRKGADCLSKWVGEAERQLRLLFEEAYRMQPS----IIFF 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1822009937 123 DDVDAVLCSRYiSNESSGVKRLVNTFIKEIDRIQSKKykfTPIITTTTNMFSLIDTAVKR--RF 184
Cdd:cd19517   105 DEIDGLAPVRS-SKQEQIHASIVSTLLALMDGLDNRG---QVVVIGATNRPDALDPALRRpgRF 164
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
50-169 2.03e-03

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 39.40  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822009937  50 NPTIMLYGSPGTGKTTLLKNVSLGLqCDDFKYFSLSLELLLD-KDLGKSSQQLKLFFEQVEESSENEEKVFLH------- 121
Cdd:COG5635   180 KKRLLILGEPGSGKTTLLRYLALEL-AERYLDAEDPIPILIElRDLAEEASLEDLLAEALEKRGGEPEDALERllrngrl 258

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1822009937 122 ---FDDVDAVlcsryisneSSGVKRlvNTFIKEIDRIQsKKYKFTPIITTT 169
Cdd:COG5635   259 lllLDGLDEV---------PDEADR--DEVLNQLRRFL-ERYPKARVIITS 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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