|
Name |
Accession |
Description |
Interval |
E-value |
| pcrA |
TIGR01073 |
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. ... |
68-821 |
0e+00 |
|
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273429 [Multi-domain] Cd Length: 726 Bit Score: 1164.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 68 LLEGLNESQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGAHPGEILAITFTNKAAGEMKERVEQLVGPRASTM 147
Cdd:TIGR01073 1 LLAHLNPEQREAVKTTEGPLLIMAGAGSGKTRVLTHRIAHLIAEKNVAPWNILAITFTNKAAREMKERVEKLLGPVAEDI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 148 WVMTFHSACVRILRRESKRLGFTSSFSIYDAADSKRLMALVCRDLDLDPKRFPPKSFSAKISNLKNELIDEEDFAARAAD 227
Cdd:TIGR01073 81 WISTFHSMCVRILRRDIDRIGINRNFSIIDPTDQLSLMKTILKDKNLDPKKFEPRSILGTISNAKNELLPPEDFAKEATN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 228 GFEKTLAQAYAMYQSRLREANALDFDDLIMTTVNLFRAFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGgasekr 307
Cdd:TIGR01073 161 YFEKVVAEVYQEYQKRLLRNNALDFDDLIMTTINLFQRVPDVLEYYQRKFQYIHVDEYQDTNRAQYTLVRLLAS------ 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 308 dedvPPAELCVVGDADQSIYAFRGATIRNILDFEEDYPDATTILLEQNYRSTQTILSAANAVIERNESRRPKNLWTNAGA 387
Cdd:TIGR01073 235 ----RFRNLCVVGDADQSIYGWRGADIQNILSFEKDYPNATTILLEQNYRSTKNILQAANEVIEHNSNRKPKNLWTENSS 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 388 GARITGYVADSEHDEAQFVADEIDRLTDAGDAKPGDVAVFYRTNAQSRVFEEVFIRVGLPYKVVGGVRFYERKEVRDVLS 467
Cdd:TIGR01073 311 GDKITYYEADTERDEAQFVAGEIDKLVKNGERKYGDFAILYRTNAQSRVFEETLLKANIPYKIVGGLKFYDRKEIKDILA 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 468 YLRVLANPEDGVPLRRILNVPKRGIGDRAEAMIEALARRERISFPQALVRVDEAYGMAARSVNAVKRFNTLMEDLRTVVE 547
Cdd:TIGR01073 391 YLRVIANPDDDLSLLRIINVPKRGIGASSLEKIVNYALELNISLFEAIGEIDEIGGLAAKSANALLAFATMIENLRQQQE 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 548 sGAGPATVLEAVLERTGYLAELQASTDPQDETRIENLQELAAVALEFEQETAEaesgSSLADFLERVALVADSDQIPDEE 627
Cdd:TIGR01073 471 -YLSPTELVEEVLDKSGYREMLKAEKTEEAQSRLENLDEFLSVTKEFEDESED----KSLIDFLTDLALVSDLDELEETE 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 628 DGnGVITLMTLHTAKGLEFPVVFLTGMEDGVFPHMRALGQVKELEEERRLAYVGITRARERLYLTRAALRSAWGQPSYNP 707
Cdd:TIGR01073 546 EG-GAVTLMTLHAAKGLEFPVVFLIGMEEGVFPHSRSLMDEKELEEERRLAYVGITRAEEELYLTHATMRTLFGRIQMNP 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 708 PSRFLEEIPETYLDWRRKGSSSPggfaagpaagvaASLSSSRSRSSAGGGSGFATRRAGDRPVVALSAGDRVTHDQFGLG 787
Cdd:TIGR01073 625 PSRFLNEIPAELLETASTGRRTG------------ATDPKGPSIRQAGASRPTTSQPTAGGDTLSWAVGDRVNHKKWGIG 692
|
730 740 750
....*....|....*....|....*....|....
gi 1822848551 788 TVVAVAGEGDKAQATIDFGDGSPKRLLLRYAPVE 821
Cdd:TIGR01073 693 TVVSVKGGGDDQELDIAFPSIGVKRLLAAFAPIE 726
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
67-799 |
0e+00 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 941.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 67 ALLEGLNESQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGAHPGEILAITFTNKAAGEMKERVEQLVGPRAST 146
Cdd:COG0210 2 DLLAGLNPEQRAAVEHPEGPLLVLAGAGSGKTRVLTHRIAYLIAEGGVDPEQILAVTFTNKAAREMRERIEALLGRLARG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 147 MWVMTFHSACVRILRRESKRLGFTSSFSIYDAADSKRLMALVCRDLDLDPKRFPPKSFSAKISNLKNELIDEEDFAARAA 226
Cdd:COG0210 82 LWVGTFHSLALRILRRHAELLGLPPNFTILDGDDQLRLIKELLKELGLDEKRFPPRELLSLISRAKNEGLTPEELAELLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 227 -DGFEKTLAQAYAMYQSRLREANALDFDDLIMTTVNLFRAFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGGase 305
Cdd:COG0210 162 aDPEWRAAAELYEAYQERLRANNALDFDDLLLLAVRLLEENPEVLEKYQNRFRYILVDEYQDTNPAQYELLRLLAGD--- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 306 krdedvpPAELCVVGDADQSIYAFRGATIRNILDFEEDYPDATTILLEQNYRSTQTILSAANAVIERNESRRPKNLWTNA 385
Cdd:COG0210 239 -------GRNLCVVGDDDQSIYGFRGADPENILRFEKDFPDAKVIKLEQNYRSTQNILDAANAVIANNPGRLGKNLWTDN 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 386 GAGARITGYVADSEHDEAQFVADEIDRLTDAGdAKPGDVAVFYRTNAQSRVFEEVFIRVGLPYKVVGGVRFYERKEVRDV 465
Cdd:COG0210 312 GEGEKVRLYVAPDEEEEARFVADEIRELHEEG-VPLSDIAVLYRTNAQSRALEEALRRAGIPYRVVGGLRFYERAEIKDL 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 466 LSYLRVLANPEDGVPLRRILNVPKRGIGDRAEAMIEALARRERISFPQALVRVDEAYGMAARSVNAVKRFNTLMEDLRTV 545
Cdd:COG0210 391 LAYLRLLANPDDDVALLRILNVPRRGIGAATLERLREAAREEGISLLEALRDLGELAGLSGRAAKALRRFAELLEALRAA 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 546 VEsGAGPATVLEAVLERTGYLAELQASTDPQDETRIENLQELAAVALEFEQEtaeaESGSSLADFLERVALVADSDQIPD 625
Cdd:COG0210 471 AE-RLPLEELLEALLDESGYEEELREEAGEEAERRLENLEELVDAAARFEER----NPGASLEAFLEELALLSDLDAADE 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 626 EEDGngvITLMTLHTAKGLEFPVVFLTGMEDGVFPHMRALGQVKELEEERRLAYVGITRARERLYLTRAALRSAWGQPSY 705
Cdd:COG0210 546 DEDA---VTLMTLHAAKGLEFPVVFLVGLEEGLFPHQRSLDDEEELEEERRLFYVAITRARERLYLTYAASRRLWGETQD 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 706 NPPSRFLEEIPETYLDWRRKGSSSPGGFAAGPAAGVAASLSSSRSRSSAGGGSGFATRRAGDRPVVALSAGDRVTHDQFG 785
Cdd:COG0210 623 NEPSRFLDELPEELLEWVRPKAEAAAAAASAAAALPASGAGAAALAAGAAAAAAAAGGGAAVAGAGLGRAAAAGGADGGA 702
|
730
....*....|....
gi 1822848551 786 LGTVVAVAGEGDKA 799
Cdd:COG0210 703 AGAGGGLAAVALTV 716
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
66-823 |
0e+00 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 680.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 66 AALLEGLNESQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGAHPGEILAITFTNKAAGEMKERVEQLVGPRAS 145
Cdd:PRK11773 4 SYLLDSLNDKQREAVAAPLGNMLVLAGAGSGKTRVLVHRIAWLMQVENASPYSIMAVTFTNKAAAEMRHRIEQLLGTSQG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 146 TMWVMTFHSACVRILRRESKRLGFTSSFSIYDAADSKRLMALVCRDLDLDPKRFPPKSFSAKISNLKNELIDEEDFAArA 225
Cdd:PRK11773 84 GMWVGTFHGLAHRLLRAHWQDANLPQDFQILDSDDQLRLLKRLIKALNLDEKQWPPRQAQWYINGQKDEGLRPQHIQS-Y 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 226 ADGFEKTLAQAYAMYQSRLREANALDFDDLIMTTVNLFRAFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGGAse 305
Cdd:PRK11773 163 GDPVEQTWLKIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYQERFTHILVDEFQDTNAIQYAWIRLLAGDT-- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 306 krdedvppAELCVVGDADQSIYAFRGATIRNILDFEEDYPDATTILLEQNYRSTQTILSAANAVIERNESRRPKNLWTNA 385
Cdd:PRK11773 241 --------GKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTANILKAANALIANNNGRLGKELWTDG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 386 GAGARITGYVADSEHDEAQFVADEIDRLTDAGDAKpGDVAVFYRTNAQSRVFEEVFIRVGLPYKVVGGVRFYERKEVRDV 465
Cdd:PRK11773 313 GDGEPISLYCAFNELDEARFVVERIKTWQDNGGAL-SDCAILYRSNAQSRVLEEALLQAGIPYRIYGGMRFFERQEIKDA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 466 LSYLRVLANPEDGVPLRRILNVPKRGIGDRAEAMIEALARRERISFPQALVRVDEAYGMAARSVNAVKRFNTLMEDLRTV 545
Cdd:PRK11773 392 LAYLRLIANRNDDAAFERVVNTPTRGIGDRTLDVVRQTARDRQLTLWQACRALLQEKVLAGRAASALQRFIELIDALAQE 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 546 VESGAGPATVlEAVLERTGYLAELQASTDPQDETRIENLQELAAVALEFEQETaEAESGSSLADFLERVALVADSDQIPD 625
Cdd:PRK11773 472 TADMPLHEQT-DRVIKDSGLRAMYEQEKGEKGQARIENLEELVTATRQFSYPD-EDEDLTPLQAFLSHAALEAGEGQADA 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 626 EEDGngvITLMTLHTAKGLEFPVVFLTGMEDGVFPHMRALGQVKELEEERRLAYVGITRARERLYLTRAALRSAWGQPSY 705
Cdd:PRK11773 550 HEDA---VQLMTLHSAKGLEFPLVFIVGMEEGLFPSQMSLEEGGRLEEERRLAYVGITRAMQKLTLTYAESRRLYGKEVY 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 706 NPPSRFLEEIPETYLD-WRRKGSSSPGGFAAGPAAGVAASLSSsrsrssagggsgfatrragdrpvvALSAGDRVTHDQF 784
Cdd:PRK11773 627 HRPSRFIREIPEECVEeVRLRATVSRPVSHQRMGTPAVEANDS------------------------GFKLGQRVRHPKF 682
|
730 740 750
....*....|....*....|....*....|....*....
gi 1822848551 785 GLGTVVAVAGEGDKAQATIDFGDGSPKRLLLRYAPVEKL 823
Cdd:PRK11773 683 GEGTIVNFEGSGAHARVQVAFQGQGIKWLVAAYAKLEAV 721
|
|
| uvrD |
TIGR01075 |
DNA helicase II; Designed to identify uvrD members of the uvrD/rep subfamily. [DNA metabolism, ... |
68-821 |
0e+00 |
|
DNA helicase II; Designed to identify uvrD members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130147 [Multi-domain] Cd Length: 715 Bit Score: 614.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 68 LLEGLNESQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGAHPGEILAITFTNKAAGEMKERVEQLVGPRASTM 147
Cdd:TIGR01075 1 LLDGLNDKQREAVAAPPGNLLVLAGAGSGKTRVLTHRIAWLLSVENASPHSIMAVTFTNKAAAEMRHRIGALLGTSARGM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 148 WVMTFHSACVRILRRESKRLGFTSSFSIYDAADSKRLMALVCRDLDLDPKRFPPKSFSAKISNLKNELIDEEDFAARAAD 227
Cdd:TIGR01075 81 WIGTFHGLAHRLLRAHHLDAGLPQDFQILDSDDQLRLLKRLIKALNLDEKQWPPRQAMWYINNQKDEGLRPSHIQAFDNP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 228 gFEKTLAQAYAMYQSRLREANALDFDDLIMTTVNLFRAFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGGASekr 307
Cdd:TIGR01075 161 -VERTWIKIYQAYQEACDRAGLVDFAELLLRAHELLRNKPHILQHYQERFTHILVDEFQDTNKIQYAWIRLLAGNTG--- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 308 dedvppaELCVVGDADQSIYAFRGATIRNILDFEEDYPDATTILLEQNYRSTQTILSAANAVIERNESRRPKNLWTNAGA 387
Cdd:TIGR01075 237 -------NVMIVGDDDQSIYGWRGAQVENIQKFLKDFPGAETIRLEQNYRSTANILAAANALIANNDERLGKNLWTDGEV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 388 GARITGYVADSEHDEAQFVADEIDRLTDAGdAKPGDVAVFYRTNAQSRVFEEVFIRVGLPYKVVGGVRFYERKEVRDVLS 467
Cdd:TIGR01075 310 GEPISLYSAFNELDEARFVVSRIKTWQRNG-GALDECAVLYRSNAQSRVLEEALLQASIPYRIYGGMRFFERQEIKDALA 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 468 YLRVLANPEDGVPLRRILNVPKRGIGDRAEAMIEALARRERISFPQALVRVDEAYGMAARSVNAVKRFNTLMEDLRtvVE 547
Cdd:TIGR01075 389 YLRLIANRNDDAAFERVINTPTRGIGDRTLDVVRQAARDRGLTLWQAARELTQEKVLAGRAASALQRFVELIEALA--NE 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 548 SGAGPATVL-EAVLERTGYLAELQASTDPQDETRIENLQELAAVALEFEQETaEAESGSSLADFLERVALVADSDQIPDE 626
Cdd:TIGR01075 467 TADMPLHVQtDHVIKDSGLREMYQQEKGEKGQARIENLEELVTATRQFSLPE-NDEDMTPLTAFLSHAALEAGEGQADAG 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 627 EDGngvITLMTLHTAKGLEFPVVFLTGMEDGVFPHMRALGQVKELEEERRLAYVGITRARERLYLTRAALRSAWGQPSYN 706
Cdd:TIGR01075 546 QDA---VQLMTLHSAKGLEFPLVFLVGMEEGMFPSQMSLDEGGRLEEERRLAYVGITRAMQKLTITYAETRRLYGKEVYH 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 707 PPSRFLEEIPETYLDW-RRKGSSSpggfaagpaagvaaslsssrsrssAGGGSGFATRRAGDRPVVA-LSAGDRVTHDQF 784
Cdd:TIGR01075 623 IPSRFIRELPEECLHEvRLRAQVS------------------------RPTNLGRVGTPSVDEINDAgFKLGQRVRHPKF 678
|
730 740 750
....*....|....*....|....*....|....*..
gi 1822848551 785 GLGTVVAVAGEGDKAQATIDFGDGSPKRLLLRYAPVE 821
Cdd:TIGR01075 679 GEGTIINAEGSGEHSRLQIAFQGQGIKWLVAAYAKLE 715
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
72-725 |
6.09e-153 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 463.16 E-value: 6.09e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 72 LNESQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGAHPGEILAITFTNKAAGEMKERVEQLVGPR-ASTMWVM 150
Cdd:PRK10919 3 LNPGQQQAVEFVTGPCLVLAGAGSGKTRVITNKIAHLIRGCGYQARHIAAVTFTNKAAREMKERVAQTLGRKeARGLMIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 151 TFHSACVRILRRESKRLGFTSSFSIYDAADSKRLMALVCRDLDLDPKRFPPKSFSAkISNLKNELIDEEDFAARAADGFE 230
Cdd:PRK10919 83 TFHTLGLDIIKREYAALGMKSNFSLFDDTDQLALLKELTEGLIEDDKVLLQQLIST-ISNWKNDLKTPAQAAAGAKGERD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 231 KTLAQAYAMYQSRLREANALDFDDLIMTTVNLFRAFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGgasekrded 310
Cdd:PRK10919 162 RIFAHCYGLYDAHLKACNVLDFDDLILLPTLLLQRNEEVRERWQNKIRYLLVDEYQDTNTSQYELVKLLVG--------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 311 vPPAELCVVGDADQSIYAFRGATIRNILDFEEDYPDATTILLEQNYRSTQTILSAANAVIERNESRRPKNLWTNAGAGAR 390
Cdd:PRK10919 233 -SRARFTVVGDDDQSIYSWRGARPQNLVLLSQDFPALQVIKLEQNYRSSGRILKAANILIANNPHVFEKRLFSELGYGDE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 391 ITGYVADSEHDEAQFVADEIDRLTDAGDAKPGDVAVFYRTNAQSRVFEEVFIRVGLPYKVVGGVRFYERKEVRDVLSYLR 470
Cdd:PRK10919 312 LKVLSANNEEHEAERVTGELIAHHFVNKTQYKDYAILYRGNHQSRVFEKFLMQNRIPYKISGGTSFFSRPEIKDLLAYLR 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 471 VLANPEDGVPLRRILNVPKRGIGDRAEAMIEALARRERISFPQALVRVDEAYGMAARSVNAVKRFNTLMEDLRTVVESga 550
Cdd:PRK10919 392 VLTNPDDDSAFLRIVNTPKREIGPATLQKLGEWAMTRNKSLFTASFDMGLSQTLSGRGYESLTRFTHWLAEIQRLAER-- 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 551 GPATVLEAVLERTGYLAEL-QASTDPQ-DETRIENLQELAAVALEFeQETAEAESGSSLADFLERVALVADSDQIPDEED 628
Cdd:PRK10919 470 EPVAAVRDLIHGIDYESWLyETSPSPKaAEMRMKNVNQLFSWMTEM-LEGSELDEPMTLTQVVTRFTLRDMMERGESEEE 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 629 GNGViTLMTLHTAKGLEFPVVFLTGMEDGVFPHMRALGQvKELEEERRLAYVGITRARERLYLTRAALRSAWGQPSYNPP 708
Cdd:PRK10919 549 LDQV-QLMTLHASKGLEFPYVYLVGMEEGLLPHQSSIDE-DNIDEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEP 626
|
650
....*....|....*..
gi 1822848551 709 SRFLEEIPETYLDWRRK 725
Cdd:PRK10919 627 SRFLLELPQDDLIWEQE 643
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
72-345 |
2.49e-119 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 361.18 E-value: 2.49e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 72 LNESQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGAHPGEILAITFTNKAAGEMKERVEQLVG-PRASTMWVM 150
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLILEGGIDPEEILAVTFTNKAAREMKERILKLLGkAELSELNIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 151 TFHSACVRILRRESKRLGFTSSFSIYDAADSKRLMALVCRDL--DLDPKRFPPKSFSAKISNLKNELIDEEDFAARAADG 228
Cdd:pfam00580 81 TFHSFCLRILRKYANRIGLLPNFSILDELDQLALLKELLEKDrlNLDPKLLRKLELKELISKAKNRLLSPEELQQGAADP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 229 FEKTLAQAYAMYQSRLREANALDFDDLIMTTVNLFRAFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGGasekrd 308
Cdd:pfam00580 161 RDKLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAGG------ 234
|
250 260 270
....*....|....*....|....*....|....*..
gi 1822848551 309 edvpPAELCVVGDADQSIYAFRGATIRNILDFEEDYP 345
Cdd:pfam00580 235 ----HENLFLVGDPDQSIYGFRGADIENILKFEKDFP 267
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
72-692 |
7.04e-115 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 369.68 E-value: 7.04e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 72 LNESQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGAHPGEILAITFTNKAAGEMKERV-------------EQ 138
Cdd:COG1074 6 WTDAQRRALDPLGGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIrerlaeaadledpDL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 139 LVGPRAST-----------MWVMTFHSACVRILRRESKRLGFTSSFSIYDAADSkRLMALVCRDL--------------- 192
Cdd:COG1074 86 EELARARRrlaralenldrAAISTIHSFCQRLLREFAFEAGLDPNFELLDDAEA-LLLEEAVDDLlreayapldalalar 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 193 --------------------DLDPKRFPPKSFSAKIS---NLKNELIDEEDFAARAADGFEKTLAQ-----------AYA 238
Cdd:COG1074 165 lldafgrdddsleelllalyKLRSRPDWLEELAELDEaleALREALLKAKEALAALREALAAAAAPllaallrllaaVLA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 239 MYQSRLREANALDFDDLIMTTVNLFR--AFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGGASEKrdedvpPAEL 316
Cdd:COG1074 245 RYERRKRERGLLDFDDLLHRALRLLRdeDAPWVAERLRERYRHILVDEFQDTSPLQWEILRRLAGEALAD------GRTL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 317 CVVGDADQSIYAFRGATIRNILDFEEDY---PDATTILLEQNYRSTQTILSAANAVIERNESRRPKNL------WTNAGA 387
Cdd:COG1074 319 FLVGDPKQSIYRFRGADPELFLEARRALegrVDGERLTLTTNFRSTPEVVDAVNALFAQLMGAGFGEIpyepveALRPGA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 388 GARIT--------GYVADSEHDEAQFVADEIDRLTDAGD--------AKPGDVAVFYRTNAQSRVFEEVFIRVGLPYKVV 451
Cdd:COG1074 399 YPAVElwplepddVSEEDAREREARAVAARIRRLLAEGTtvegggrpVRPGDIAVLVRTRSEAAAIARALKAAGIPVAAS 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 452 GGVRFYERKEVRDVLSYLRVLANPEDGVPLRRILNVPkrGIGDRAEAMIEALARRERISFPQALVRvdeaygmAARSVNA 531
Cdd:COG1074 479 DRLSLFESPEVRDLLALLRALLNPEDDLALAAVLRSP--LFGLSDEDLAALAADRKGESLWEALRA-------YERLARA 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 532 VKRFNTLMEDLRTVvesgaGPATVLEAVLERTGYLAELQASTD-PQDETRIENLQELAAVALEFEQETAEAESGssLADF 610
Cdd:COG1074 550 LERLRALRELARRL-----GLAELLERLLEETGLLERLLALPGgERRLANLLHLDELLQLALEYEQTGGPGLAG--FLRW 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 611 LERVALVADSDQIPDEEDGNGVITLMTLHTAKGLEFPVVFLtgmedgvfPHMRALGQVKELEEERRLAYVGITRARERLY 690
Cdd:COG1074 623 LERLIEDGGDEEKRRLESDADAVRIMTIHKSKGLEFPVVFL--------PALRERARAEELAEELRLLYVALTRARDRLV 694
|
..
gi 1822848551 691 LT 692
Cdd:COG1074 695 LS 696
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
73-356 |
1.46e-87 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 275.16 E-value: 1.46e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 73 NESQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGAHPGEILAITFTNKAAGEMKERVEQLVGP-RASTMWVMT 151
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLILEGGVPPERILAVTFTNKAAKEMRERLRKLLGEqLASGVWIGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 152 FHSACVRILRREskrlgftssfsiydaadskrlmalvcrdldldpkrfppksfsakisnlknelideedfaaraadgfek 231
Cdd:cd17932 81 FHSFALRILRRY-------------------------------------------------------------------- 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 232 tlaqayamyqsrlreanaLDFDDLIMTTVNLFRAFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGgasekrdedv 311
Cdd:cd17932 93 ------------------GDFDDLLLYALELLEENPDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAG---------- 144
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1822848551 312 PPAELCVVGDADQSIYAFRGATIRNILDFEEDYPDATTILLEQNY 356
Cdd:cd17932 145 DGKNLFVVGDDDQSIYGFRGADPENILDFEKDFPDAKVIKLEENY 189
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
350-692 |
1.68e-78 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 258.49 E-value: 1.68e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 350 ILLEQNYRSTQTILSAANAVIERNESRRP----KNLWTNAGAGARITGYVADSEHDEAQFVADEIDRLtDAGDAKPGDVA 425
Cdd:pfam13361 1 IHLEINYRSTKNLLKAANEFINNNFGRATiypkKILAETVEDGEKIKIIEAETEEEEAEWIALEIKKL-VARDEKYNDIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 426 VFYRTNAQSRVFEEVFIRVGLPYKVVGGVRFYERKEVRDVLSYLRVLANPEDGVPLRRILNVPKRGIGDRA--------- 496
Cdd:pfam13361 80 VLTRSNSDADLIEEALKKLGIPYFVVGQTKFFRREEIKDILAYLRLIANKHDSISLKRILNGPKRGIGNATlerireykk 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 497 -----------------EAMIEALARRERISFPQALVRV----DEAYGMAA--RSVNAV--KRFNTLMEDLRTVVES--- 548
Cdd:pfam13361 160 rglrlsdfinpdtltygDPFVIALEQDNIVVFDVETTGLdtteDEIIQIAAikLNKKGVviESFERFLRLKKPVGDSlqv 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 549 -----------GAGPATVLEAVLErtgylaelqastdpqdetRIENLQELAAVALEFEQETAEAESGSSLADFLERVALV 617
Cdd:pfam13361 240 hgfsdeflqenGETPAEALRDFLE------------------KLENLRELYSILREYDDIEETPEPEDALRNFLEIATLS 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1822848551 618 ADSDQipdEEDGNGVITLMTLHTAKGLEFPVVFLTGMEDGVFPHMRALGQVKELEEERRLAYVGITRARERLYLT 692
Cdd:pfam13361 302 NSELE---GSDIKERIPIMTIHQAKGLEFDTVFLAGLEEGIFPSYRSIKDEGNLEEERRLFYVAITRAKKRLYIS 373
|
|
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
74-691 |
3.49e-43 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 169.88 E-value: 3.49e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 74 ESQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAHLLAeRGAHPGEILAITFTNKAAGEMKERVE---------------- 137
Cdd:TIGR02785 4 DEQWQAIYTRGQDILVSASAGSGKTAVLVERIIRKIT-RGVDVDRLLVVTFTNAAAREMKERIAealekelvqepnskhl 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 138 --QLVG-PRAStmwVMTFHSACVRILRR--------ESKRLG-------------------------------FTSSFS- 174
Cdd:TIGR02785 83 rrQLALlNTAN---ISTLHSFCLKVIRKhyylldldPSFRILtdteqlllikevlddvfeeeyykedkeaffeLVDNFSg 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 175 -------------IYDAA-------------------------DSKRLMALVCRDL----------------------DL 194
Cdd:TIGR02785 160 drsddglrdlilqLYDFSrstpnpekwlnnlaeayevkekftiESLKLQQQIKELLkneleglqeklqralelfmaedGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 195 DPK-------------------------------------RFPPKSFSAKISNLKNE---LIDE---------EDFAARA 225
Cdd:TIGR02785 240 APRlenfqldlqnideliqeslaqadwnelrkavaafkfkNLKAAKGDEEDADLLEEadkLREEakkqleklkTDYFTRS 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 226 ADGFEKTLAQAYAM--------------YQSRLREANALDFDDLIMTTVNLFRAFPD----VAEHYRRRFRHVLVDEYQD 287
Cdd:TIGR02785 320 EEDHLRIMQEMKPVvktlvqlvkdfierFGAEKREKNILDFSDLEHYALQILTNENEspseAAEFYREKFHEVLVDEYQD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 288 TNHAQYALVRELvggaseKRDEDvPPAELCVVGDADQSIYAFRGAtirNILDFEEDYPDATT--------ILLEQNYRST 359
Cdd:TIGR02785 400 TNLVQESILQLV------KRGPE-EEGNLFMVGDVKQSIYRFRQA---DPLLFLEKYHRFAQegeehgkrIDLAENFRSR 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 360 QTILSAANAVIERNESRR---------------PKNLWTNAGAGARITGY-----------VADSEHD-------EAQFV 406
Cdd:TIGR02785 470 AEVLDTTNFLFKQLMDEEvgeidydeeaqlkfgAAKYPENPDNKTEELLYekllieeaeeeEIDEEAEildkaqqEATMV 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 407 ADEIDRLTDAG----DAKPG--------DVAVFYRTNAQSRVFEEVFIRVGLPYKVVGGVRFYERKEVRDVLSYLRVLAN 474
Cdd:TIGR02785 550 AERIKALIKEGfkvyDKKTGtyrpvtyrDIVILTRSRGWNLQIMEEFKKYGIPVFANDAENYFQTTEVRVMLSLLRVIDN 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 475 PEDGVPLRRILNVPKRGIGDRAEAMIEalARRERISFPQALVRVDEAYGMAARSVNAVKRFNTLMEDLRTVVESGAgPAT 554
Cdd:TIGR02785 630 PYQDIPLVAVLRSPIVGFDENELALIR--LENKDSSYYEAVKDYVKAGLIEDELYEKLNTFLDSLQKWREFARTHS-VSE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 555 VLEAVLERTGYLAELQAStdPQDETRIENLQELAAVALEFEQetaeaESGSSLADFLERVALVADSDQ-------IPDEE 627
Cdd:TIGR02785 707 LIWKIYNDTGYYDYVGGL--PGGKQRQANLYALYERARQYES-----TSFKGLFQFIRFIERMQERQKdlasavaVGEAE 779
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 628 DgngVITLMTLHTAKGLEFPVVFLTGM-----------------EDGV------------FPHM--RALGQVKELE---E 673
Cdd:TIGR02785 780 N---AVRLMTIHKSKGLEFPVVFVLGMgkqfnkqdlnssylldrQLGLgikyidpqerlsYPSLpkVAIKQKMKREllsE 856
|
890
....*....|....*...
gi 1822848551 674 ERRLAYVGITRARERLYL 691
Cdd:TIGR02785 857 EMRVLYVALTRAKEKLIL 874
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
232-692 |
2.04e-30 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 129.42 E-value: 2.04e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 232 TLAQAY-AMYQSRLREANALDFDDLIMTTVNLFRAfPDVAE--HYR--RRFRHVLVDEYQDTNHAQYALVREL-----VG 301
Cdd:TIGR02784 342 RLAARLlQRYARLKKARGLLDFNDLIERTVALLAR-PGAGAwvHYKldRGIDHILVDEAQDTSPEQWDIIQALaeeffSG 420
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 302 GASEKRDEDVppaeLCVVGDADQSIYAFRGATIRNILDFEEDYPDATT--------ILLEQNYRSTQTILSAANAVIERN 373
Cdd:TIGR02784 421 EGARSGVERT----IFAVGDEKQSIYSFQGADPERFAEERREFSRKVRavgrkfedLSLNYSFRSTPDVLAAVDLVFADP 496
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 374 ESRR----PKNLWTNAGAGARITGYV--------ADSEHDE------------------AQFVADEIDRLTDAGD----- 418
Cdd:TIGR02784 497 ENARglsaDSDAPVHEAFRDDLPGRVdlwdliskEEGEEPEdwtdpvdelgerapevrlAERIAAEIRAWLDRGTpipgr 576
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 419 ---AKPGDVAVFYRTnaQSRVFEEV---FIRVGLPykVVGGVRFYERKE--VRDVLSYLRVLANPEDGVPLRRILNVPKR 490
Cdd:TIGR02784 577 graVRPGDILVLVRK--RDAFFSALiraLKRRGIP--VAGADRLKLTSHiaVKDLMALGRFVLQPEDDLSLAALLKSPLF 652
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 491 GIGDraEAMIEALARRERISFPQALVRVDEAYGMAARSVNAVKRfntlMEDLRTVVEsgagpatVLEAVLERTGYLAELQ 570
Cdd:TIGR02784 653 GLDE--DDLFRLAAGRSGGSLWAALRRREAEFAATLAVLRDWLS----LADFLTPFE-------FYARLLGRDGGRRKLL 719
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 571 ASTDPQDEtriENLQELAAVALEFEQETAeaesgSSLADFLErvALVADSDQIPDEEDGNG-VITLMTLHTAKGLEFPVV 649
Cdd:TIGR02784 720 ARLGAEAE---DILDEFLSQALAYERTGL-----PGLQAFLS--WLEADDPEIKREMDQARdEVRVMTVHGAKGLEAPVV 789
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1822848551 650 FL--TGME---DGVFPHMRALG---------------------------QVKELEEERRLAYVGITRARERLYLT 692
Cdd:TIGR02784 790 FLvdTGSKpfaSQRAPLLLATGgsggkaplwrpasafdpslsaaarerlKERAEDEYRRLLYVAMTRAEDRLIVC 864
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
358-692 |
1.14e-29 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 115.02 E-value: 1.14e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 358 STQTILSAANAVIERNESRRPKNLWTNAGAGARITGYVADSEHDEAQFVADEIDRLTDAGDAKPGDVAVFYRTNAQSRVF 437
Cdd:cd18807 1 STKNILDAANSLIKQNKNRPKKPLKAGNKSGGPVELLLAKDEADEAKAIADEIKRLIESGPVQYSDIAILVRTNRQARVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 438 EEVfirvglpykvvggvrfyerkevrdvlsyLRVlanpedgvplrrilnvpkrgigdraeamiealarrerisfpqalvr 517
Cdd:cd18807 81 EEA----------------------------LRV---------------------------------------------- 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 518 vdeaygmaarsvnavkrfntlmedlrtvvesgagpatvleavlertgylaelqastdpqdetrienlqelaavalefeqe 597
Cdd:cd18807 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 598 taeaesgssladflervalvadsdqipdeedgngviTLMTLHTAKGLEFPVVFLTGMEDGVFPHMRALGQVKE----LEE 673
Cdd:cd18807 87 ------------------------------------TLMTIHASKGLEFPVVFIVGLGEGFIPSDASYHAAKEdeerLEE 130
|
330
....*....|....*....
gi 1822848551 674 ERRLAYVGITRARERLYLT 692
Cdd:cd18807 131 ERRLLYVALTRAKKELYLV 149
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
91-689 |
1.99e-28 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 122.77 E-value: 1.99e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 91 AGAGSGKTRVLTHR-IAHLLaeRGAHPGEILAITFTNKAAGEMKERV---------------------------EQLVGP 142
Cdd:PRK13909 5 ASAGSGKTFALSVRfLALLF--KGANPSEILALTFTKKAANEMKERIidtllnlekekeeselneleeklglskEELLNK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 143 RASTMW--------VMTFHSACVRILRRESKRLGFTSSFSIYD------------AADSKRLMALV-----CRDLDL--- 194
Cdd:PRK13909 83 RDKVYQeflnselkISTIDAFFQKILRKFCLNLGLSPDFSIKEdtkeelnekflsALSKEELLELLafikqCESKKNnsf 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 195 -----------------DPKRFPPK----SFSAKISNLKNELIDEEDFAARAADGFEKT--------------------- 232
Cdd:PRK13909 163 felleklyeknnelklfEKAKNPIEfdeeKFLEELRSLKQQIQSIETASKNAKKAFKKEdfeellnssktwlekeseyry 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 233 ----------------------------------LAQAYAMYQSRLREA----NALDFDDL------IMTTVNLFRAFpd 268
Cdd:PRK13909 243 fkklyneeldaefeelknalkryydakenyklskLFKLLQLYKEAKNELnkkkNALDFDDIskkvyeLLGEEEIDKDF-- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 269 vaeHYRR---RFRHVLVDEYQDTNHAQY----ALVRELVGGASEKRDEDVppaelCVVGDADQSIYAFRGATiRNILDF- 340
Cdd:PRK13909 321 ---LYFRldsKISHILIDEFQDTSVLQYkillPLIDEIKSGEGQKKFRSF-----FYVGDVKQSIYRFRGGK-KELFDKv 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 341 EEDYPDATTIlLEQNYRSTQTILSAANAV-IERNESRRPKNLWTNAGAgaritGYV-----ADSEHDEAQFVADEIDRLT 414
Cdd:PRK13909 392 SKDFKQKVDN-LDTNYRSAPLIVDFVNEVfKKKYKNYKTQYAEQHKSG-----GYVevvevADESEELLEQLLQEIQFLL 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 415 DAGdAKPGDVAVFYRTNaqsrvfeevfirvglpykvvggvrfyerKEVRDVLSYLrvlaNPEDGVPLR-----RILNVPK 489
Cdd:PRK13909 466 EKG-IDPDDIAILCWTN----------------------------DDALEIKEFL----QEQFGIKAVtessaKLINQPE 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 490 rgigdrAEAMIEALarrerisfpQALVRVDEAYgmaARSVNAV--KRFNTLMEDLRTVVEsgagPATVLEAVLERTGYLA 567
Cdd:PRK13909 513 ------VKALIEAL---------KYCLFGEEIY---KHNVLKLlgKEPDKIPSFLPKEES----VAEFVKKLIEELKLYD 570
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 568 elqastdpqdetriENLQELAAVALEFEqetaeaesgsSLADFLERVALvaDSDQIPDEE-DGngvITLMTLHTAKGLEF 646
Cdd:PRK13909 571 --------------ENLLKFLELASGYE----------DIEEFLFKLEP--CDKEIASEEsKG---VQIMTVHKSKGLEF 621
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1822848551 647 PVV---------------FLTGMEDGVFPHM---------------RALGQVKEL--EEERRLAYVGITRARERL 689
Cdd:PRK13909 622 EHVivcdrlgkpnsdssnLLFEYDGIELWQIyyrikgrenfdkdyaRALEKEKALkyEEEINVLYVAFTRAKNSL 696
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
72-381 |
2.09e-28 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 121.98 E-value: 2.09e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 72 LNESQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGAHPGEILAITFTNKAAGEMKERVEQLVGPRASTmwVMT 151
Cdd:PRK11054 197 LNPSQARAVVNGEDSLLVLAGAGSGKTSVLVARAGWLLARGQAQPEQILLLAFGRQAAEEMDERIRERLGTEDIT--ART 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 152 FHSACVRILRRESKRLGFTSSFsiydAADSKRLMALVCRDLDldpKRFPPKSFSAK------ISNLKNElIDEEDF---- 221
Cdd:PRK11054 275 FHALALHIIQQGSKKVPVISKL----ENDSKARHALLIAEWR---KQCSEKKAQAKgwrqwlTEELQWD-VPEGNFwdde 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 222 --AARAAD--------GFEKTLAQAyAM-------------------------YQSRLREANALDFDDLIMTTVNLFRaf 266
Cdd:PRK11054 347 klQRRLASrlerwvslMRMHGGSQA-EMiaqapeevrdlfqkrlklmapllkaWKKALKAENAVDFSGLIHQAVNYLE-- 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 267 pdvaehyRRRF----RHVLVDEYQDTNHAQYALVRELvggasekRDEDvPPAELCVVGDADQSIYAFRGATIRNILDFEE 342
Cdd:PRK11054 424 -------KGRFispwKHILVDEFQDISPQRAALLAAL-------RKQN-SQTTLFAVGDDWQAIYRFSGADLSLTTAFHE 488
|
330 340 350
....*....|....*....|....*....|....*....
gi 1822848551 343 DYPDATTILLEQNYRSTQTILSAANAVIERNESRRPKNL 381
Cdd:PRK11054 489 RFGEGDRCHLDTTYRFNSRIGEVANRFIQQNPHQLKKPL 527
|
|
| AddB |
COG3857 |
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair]; |
88-725 |
5.63e-26 |
|
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
Pssm-ID: 443066 [Multi-domain] Cd Length: 1019 Bit Score: 114.84 E-value: 5.63e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 88 LIVAGAGSGKTRVLTHRIAHLLAErgahpGEILAITFTNKAAGEMKERVEQLVGPRASTMW-VMTFHsacvRILRRESKR 166
Cdd:COG3857 2 FILGRAGSGKTTYLLEEIKEELKE-----GKPIILLVPEQMTFQAERALLKRLGLGGSIRAqVLSFS----RLAWRVLQE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 167 LGFTSSFSIyDAADSKRLMALVCRDLDLDPKRFPP--------KSFSAKISNLKNELIDEEDFAARAADGFEKT--LAQA 236
Cdd:COG3857 73 TGGATRPLL-SDAGKRMLLRKILEEHKDELKVFARaadkpgfiEQLAELITELKRYGITPEDLEEAAELLKEKLrdLALI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 237 YAMYQSRLREaNALDFDDLIMTTVNLFRAFPDVAEHyrrrfrHVLVDEYQDTNHAQYALVRELVGGASEKRdedvppAEL 316
Cdd:COG3857 152 YEAYEEKLAG-RYIDSEDLLRLLAEKLEKSEFLEGA------EIYIDGFTDFTPQELELLEALLKKAKEVT------ITL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 317 CVvGDADQSIYAFRGATIRNILDFeedypdATTILLEQNYRSTQTIlsaanAVIERNESRRPKNlwtnaGAGARITGYVA 396
Cdd:COG3857 219 TL-DPDELDLFSATGETYERLLEL------AKENGVEVEFKKSPEL-----AHLERNLFAYPPE-----EEPEGIEIIEA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 397 DSEHDEAQFVADEIDRLTDAGDAKPGDVAVFYR-TNAQSRVFEEVFIRVGLPYKVVGGVRFYERKEVRDVLSYLRVLANP 475
Cdd:COG3857 282 ANRRAEVEAVAREIRRLVREEGYRYRDIAVVVRdLEAYAPLIERVFAEYGIPYFIDEKRPLSHHPLVELILSLLELVRSN 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 476 EDGVPLRRILNVP-KRGIGDRAEAMIEALARRERI-------SFPQALVRVDEAYGMAARSVNAVKRFntLMEDLRTVVE 547
Cdd:COG3857 362 FRYEDVFRLLKTGlLRPLSREEIDRLENYVLAYGIrgrrwleRYLEEEEELTDEEEEDLERLNELRDR--LLEPLLPLRE 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 548 SGAGPATVLEAV------LERTGYLAELQASTDPQDETRIENLQELAAVALEFEQ-----ETAEAESGSSLADFLERVAL 616
Cdd:COG3857 440 RLKKAKTVREWAealyefLEELGVPEKLEEWREAEEAGDLEEAREHEQAWNALIElldelVEVLGDEKLSLEEFLRILES 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 617 VADSDQIPDEEDGNGVITLMTLHTAKGLEFPVVFLTGMEDGVFP---------------HMRALGQVKE------LEEER 675
Cdd:COG3857 520 GLEELTFGLIPPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFParpredgllsdeereRLNELGLELPptsrerLLEER 599
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|
gi 1822848551 676 RLAYVGITRARERLYLTRaALRSAWGQPsyNPPSRFLEEIPETYLDWRRK 725
Cdd:COG3857 600 FLFYRALTRASERLYLSY-PLADEEGKA--LLPSPLIDRLRELFPELEER 646
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
76-330 |
9.08e-16 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 74.56 E-value: 9.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 76 QRDAV--THAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGAhPGEILAITFTNKAAGEMKERveqLVGPrastmwVMTFH 153
Cdd:pfam13245 1 QREAVrtALPSKVVLLTGGPGTGKTTTIRHIVALLVALGGV-SFPILLAAPTGRAAKRLSER---TGLP------ASTIH 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 154 sacvrilrreskrlgftssfsiydaadskRLMalvcrdldldpkrfppksfsakisnlknelideeDFAARAADGFEKtl 233
Cdd:pfam13245 71 -----------------------------RLL----------------------------------GFDDLEAGGFLR-- 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 234 aqayamyqsrlREANALDFDdlimttvnlfrafpdvaehyrrrfrHVLVDEYQDTNHA-QYALVRELVGGasekrdedvp 312
Cdd:pfam13245 86 -----------DEEEPLDGD-------------------------LLIVDEFSMVDLPlAYRLLKALPDG---------- 119
|
250
....*....|....*...
gi 1822848551 313 pAELCVVGDADQSIYAFR 330
Cdd:pfam13245 120 -AQLLLVGDPDQLPSVGP 136
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
86-692 |
1.86e-14 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 77.18 E-value: 1.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 86 PLLIVAGAGSGKTRVLTHRIAHLLAErgaHPGEILAITFTNKA-AGEMKERVEQ-LVGPRASTMW----VMTFHSACVRI 159
Cdd:COG3972 175 PQRIRGVAGSGKTVLLAAKAAYLALK---HPGWRILVTCFNRSlADHLRDLIPRfLRRFSNGEPEdnvkLIVFHAWGGKL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 160 LRR-ESKRLGFTSSFSIYDAAdskrlmalvCRDLdldpkrfppksfsakisnlknelideedfaaraadgfektlaqaya 238
Cdd:COG3972 252 LKQyGIPPLTFSQPNEAFDEA---------CKAL---------------------------------------------- 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 239 myqsrLREANALDFddlimttvnlfrafpdvaehyRRRFRHVLVDEYQDTNHAQYALVRELVggasekrdeDVPPAELCV 318
Cdd:COG3972 277 -----LEAIQGEII---------------------PPIYDAILIDEAQDFEPEFLRLLYQLL---------KPPKKRLIW 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 319 VGDADQSIYAFRGATIRNIldfeEDYPDATTILlEQNYRSTQTILSAANAVIERnesrrpknlwtnagagaritgyvads 398
Cdd:COG3972 322 AYDEAQNIYGRKIPSAGGI----PAGIGRDTIL-KKNYRNTRPILTFAHAFGMG-------------------------- 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 399 ehdeaqfvadeidrltdagdakpgdvavFYRTnaqsrvfeevfirvglPYKVVGGVRFYERKevrdvlsylrvlaNPEDG 478
Cdd:COG3972 371 ----------------------------LLRP----------------PGLLQGDAEDYEVE-------------RPGDK 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 479 VPLRRilnvPKRGIGDRAEAMIealarrerisfpqalvrvdeaygmaarsvnaVKRFNTLMEDLRTVVEsgagpatvlea 558
Cdd:COG3972 394 VTLIR----PPEPAGRKGPLPE-------------------------------FKKYDDRAEELEAIAE----------- 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 559 vlertgylaELQAstDPQDETRieNLQELAAVALEfeqETAEAESGSSLADFLER---VALVADSDQIPDEEDGNGVITL 635
Cdd:COG3972 428 ---------EIKK--NLRDEGL--RPSDIAVIYLG---NNEAKELGDRLAAALERqgiDSYIAGARSDPNFFWKDGGVTI 491
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 1822848551 636 MTLHTAKGLEFPVVFLTGMEDgvfphmraLGQVKELEEERRLAYVGITRARERLYLT 692
Cdd:COG3972 492 STIHRAKGLEAPVVIIVGLDQ--------LAKGESLERLRNLLYVAMTRARGWLVVS 540
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
86-159 |
3.06e-13 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 67.13 E-value: 3.06e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1822848551 86 PLLIVAGAGSGKTRVLTHRIAHLLAERGAHPGEILAITFTNKAAGEMKERV--EQLVGPRASTMWVMTFHSACVRI 159
Cdd:cd17914 1 LSLIQGPPGTGKTRVLVKIVAALMQNKNGEPGRILLVTPTNKAAAQLDNILvdEAAQILEPETSRLIDLALDQGRV 76
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
275-356 |
3.30e-12 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 64.04 E-value: 3.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 275 RRFRHVLVDEYQDTNHAQYALVRELVGGAsekrdedvppAELCVVGDADQSIYAFRGATIRN-----ILDFEEDYPDATT 349
Cdd:cd17914 45 AQLDNILVDEAAQILEPETSRLIDLALDQ----------GRVILVGDHDQLGPVWRGAVLAKicneqSLFTRLVRLGVSL 114
|
....*..
gi 1822848551 350 ILLEQNY 356
Cdd:cd17914 115 IRLQVQY 121
|
|
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
270-685 |
2.87e-11 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 67.30 E-value: 2.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 270 AEHYRRRFRHVLVDEYQDTNHAQYALVRELVGGAsekrdedvPPAELCVVGDADQSIYAFRGATIRNILDFEEDYPDATT 349
Cdd:PRK10876 371 AAAIRTRYPVAMIDEFQDTDPQQYRIFRRIYRHQ--------PETALLLIGDPKQAIYAFRGADIFTYMKARSEVSAHYT 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 350 ilLEQNYRSTQTILSAANAVI--------------------ERNESRR---------PKNLWTNAGAGARITGYvadsEH 400
Cdd:PRK10876 443 --LDTNWRSAPGMVNSVNKLFsqtddpflfreipfipvkaaGKNQALRfvvkgetqpAMKFWLMEGEGVGVGDY----QQ 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 401 DEAQFVADEIDR-----------LTDAGDAKP---GDVAVFYRTNAQSRVFEEVFIRVGLPyKVVGGVR--FYERKEVRD 464
Cdd:PRK10876 517 TMAQQCAAQIRDwlqagqrgealLMNGDDSRPvraSDITVLVRSRQEAALIRDALTLLAIP-SVYLSNRdsVFETLEAQE 595
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 465 VLSYLRVLANPEDGVPLRRILNVPKRGIGDRAeamIEALARRERISfpQALvrVDEAYGMAARsvnAVKRfntlmedlrt 544
Cdd:PRK10876 596 MLWLLQAVLAPERERTLRSALATSMMGLDALD---IDALNNDERAW--DAL--VEEFDGYRQI---WRKR---------- 655
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 545 vvesgaGPATVLEAVLERTgYLAE-LQASTDpqDETRI-------ENLQElAAVALEFE--------QETAEAESGSSla 608
Cdd:PRK10876 656 ------GVLPMLRALMSAR-NIAEnLLATAG--GERRLtdilhigELLQE-ASSQLDSEhalvrwlaQQILEPDSQAS-- 723
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 609 dflervalvadSDQIPDEEDGNgVITLMTLHTAKGLEFPVVFLT-----GMEDGVFPHMR----------------ALGQ 667
Cdd:PRK10876 724 -----------SQQLRLESDKH-LVQIVTIHKSKGLEYPLVWLPfitnfRVQDQAFYHDRhsfeavldlnaaeesvALAE 791
|
490
....*....|....*...
gi 1822848551 668 VKELEEERRLAYVGITRA 685
Cdd:PRK10876 792 EERLAEDLRLLYVALTRS 809
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
275-435 |
4.98e-11 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 66.43 E-value: 4.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 275 RRFRHVLVDEYQDTNHAQYALVRELVGGASekrdedvppaeLCVVGDADQSIYAFRGATIRNILDFEEDYPDATTILLEQ 354
Cdd:COG3973 468 WTYGHVVVDEAQDLSPMQWRVLKRRFPSAS-----------FTIVGDLAQAIHPYRGAESWEEVLEPLGGDRARLVELTK 536
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 355 NYRSTQTILSAANAVIERNES--------RRpknlwtnagAGARITGYVADSEHDEAQFVADEIDRLTDAGDakpGDVAV 426
Cdd:COG3973 537 SYRSTAEIMEFANRVLRAAGPdlpppesvRR---------HGEPPRVVRVPSEAELAAAVVEAVRELLAEGE---GTIAV 604
|
....*....
gi 1822848551 427 FYRTNAQSR 435
Cdd:COG3973 605 ICKTAREAE 613
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
612-692 |
3.23e-09 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 54.37 E-value: 3.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 612 ERVALVADSDQIPDEEDGNGVITLMTLHTAKGLEFPVVFLTGMEDGvfphmralgqvkelEEERRLAYVGITRARERLYL 691
Cdd:cd18786 22 DRAYLNQYLQGLSLDEFDLQLVGAITIDSSQGLTFDVVTLYLPTAN--------------SLTPRRLYVALTRARKRLVI 87
|
.
gi 1822848551 692 T 692
Cdd:cd18786 88 Y 88
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
633-692 |
3.65e-09 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 52.96 E-value: 3.65e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 633 ITLMTLHTAKGLEFPVVFLTGMEDGVFPHMralgqvkelEEERRLAYVGITRARERLYLT 692
Cdd:pfam13538 2 AYALTVHKAQGSEFPAVFLVDPDLTAHYHS---------MLRRRLLYTAVTRARKKLVLV 52
|
|
| DEAD-like_helicase_N |
cd17912 |
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ... |
87-132 |
1.20e-06 |
|
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.
Pssm-ID: 350670 [Multi-domain] Cd Length: 81 Bit Score: 47.13 E-value: 1.20e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1822848551 87 LLIVAGAGSGKTRVLTHRIAHLLaergAHPGEILAITFTNKAAGEM 132
Cdd:cd17912 2 ILHLGPTGSGKTLVAIQKIASAM----SSGKSVLVVTPTKLLAHEI 43
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|
| SF1_C_RecD |
cd18809 |
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11. ... |
636-691 |
1.94e-06 |
|
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350196 [Multi-domain] Cd Length: 80 Bit Score: 46.40 E-value: 1.94e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1822848551 636 MTLHTAKGLEFPVVFLtgMEDGVFPHMralgqvkeleeERRLAYVGITRARERLYL 691
Cdd:cd18809 36 MTIHKSQGSEFDRVIV--VLPTSHPML-----------SRGLLYTALTRARKLLTL 78
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
636-699 |
9.60e-05 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 45.74 E-value: 9.60e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1822848551 636 MTLHTAKGLEFPVVFLTgMEDGVFPHMRalgqvkeleeeRRLAYVGITRARER--LYLTRAALRSA 699
Cdd:COG0507 445 ITVHKSQGSTFDRVILV-LPSEHSPLLS-----------RELLYTALTRARELltLVGDRDALARA 498
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
72-146 |
2.14e-04 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 44.58 E-value: 2.14e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1822848551 72 LNESQRDAVTHA--GSPLLIVAG-AGSGKTRVLtHRIAHLLAERGahpGEILAITFTNKAAgemkERVEQLVGPRAST 146
Cdd:COG0507 125 LSDEQREAVALAltTRRVSVLTGgAGTGKTTTL-RALLAALEALG---LRVALAAPTGKAA----KRLSESTGIEART 194
|
|
| AAA_30 |
pfam13604 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
71-134 |
4.06e-04 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.
Pssm-ID: 433343 [Multi-domain] Cd Length: 191 Bit Score: 42.17 E-value: 4.06e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1822848551 71 GLNESQRDAVTH-AGSP---LLIVAGAGSGKTRVLTHrIAHLLAERGahpGEILAITFTNKAAGEMKE 134
Cdd:pfam13604 1 TLNAEQAAAVRAlLTSGdrvAVLVGPAGTGKTTALKA-LREAWEAAG---YRVIGLAPTGRAAKVLGE 64
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
545-694 |
8.34e-04 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 42.93 E-value: 8.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 545 VVESGAGPATVLEAVlERTGYLAELQASTDPQDEtrIENLQELAAVALEFEQET-----AEAESGSSLADFLERVALVAD 619
Cdd:COG3973 551 VLRAAGPDLPPPESV-RRHGEPPRVVRVPSEAEL--AAAVVEAVRELLAEGEGTiavicKTAREAEALYAALKAGLPVTL 627
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1822848551 620 SDqiPDEEDGNGVITLMTLHTAKGLEFPVVFLtgmedgVFPHmralGQVKELEEERRLAYVGITRARERLYLTRA 694
Cdd:COG3973 628 ID--DESEELEAGVVVLPAYLAKGLEFDAVVV------VDPD----EIVYESPRGRRLLYVALTRATHRLTVLHT 690
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
87-186 |
3.85e-03 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 39.20 E-value: 3.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822848551 87 LLIVAGAGSGKTRVLtHRIAHLLAERGAHPGEILAITFTNkAAGEMKERVEQLVGPRASTMWVMTFHSACVRILRRESKR 166
Cdd:cd17930 4 VILEAPTGSGKTEAA-LLWALKLAARGGKRRIIYALPTRA-TINQMYERIREILGRLDDEDKVLLLHSKAALELLESDEE 81
|
90 100
....*....|....*....|
gi 1822848551 167 LGFTSSFSIYDAADSKRLMA 186
Cdd:cd17930 82 PDDDPVEAVDWALLLKRSWL 101
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