|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
4-774 |
0e+00 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 578.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 4 FLDILERAVFRHRLFAIISFALITCFLLFKATQIQLDASFNKNIPLNHDYMKVYTKHEKQFGGANSILISVCDADgDIFN 83
Cdd:COG1033 3 LMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGDDTVVVAVEGKD-DIFT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 84 EEFFTQLKAVHDQLYFIPGVNRplVNSIFapSARFVEVVEDGFAGGPIIPANFTADKRGLAVVKENIEKAK-VVGRMIAS 162
Cdd:COG1033 82 PETLEALRELTEELEEIPGVDS--VTSLT--NVRATEGTEDGLTVEPLIPDELPASPEELAELREKVLSSPlYVGRLVSP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 163 DYSCAMVTAQLlETDPQTqEKLDTLAFAEKLETQVREpLSTDKVSIHIIGFAKMAGDVAEGAKGVL-LFFAIAIAFTFVM 241
Cdd:COG1033 158 DGKATLIVVTL-DPDPLS-SDLDRKEVVAEIRAIIAK-YEDPGVEVYLTGFPVLRGDIAEAIQSDLaIFFPLALLLILLL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 242 VWLFCHSLKLTILPIACSIIAVVWQLGLLSSLGFGLDPMSILVPFLVFAIGVSHGVQMINDIGKKVSTGSSTRVCCQASF 321
Cdd:COG1033 235 LFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALREAL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 322 RALLIPGGIALLSDTIGFLTLLTIDIGIIRELAITASLGVAVIIFTNLILLPVWASYMRFEGSVHIQAGTHTDKPNLLDK 401
Cdd:COG1033 315 RKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPPELGRLLAK 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 402 LRELLVKAtdrktAGFIIAFTAVLFAVGYWQADKMRIGDLHAGapSLHQDARYNQDTFLISDKYTiSSDILKVIVEAY-P 480
Cdd:COG1033 395 LARFVLRR-----PKVILVVALVLAVVSLYGISRLKVEYDFED--YLPEDSPIRQDLDFIEENFG-GSDPLEVVVDTGeP 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 481 AACTEHDVMERISRFQWQMENVAGVQSAVSLSSVAQSVNAGFNEGNLKWQSLPRNTASLVQ-----ATSRVETSSGLLDG 555
Cdd:COG1033 467 DGLKDPEVLKEIDRLQDYLESLPEVGKVLSLADLVKELNQALNEGDPKYYALPESRELLAQlllllSSPPGDDLSRFVDE 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 556 NCSVMPVIIFLNDHKAETIDHVVAKVKEFAKAE-ETDELKFKLAsGPVGVMAATNESVSAAQLPMMLYVYGAVILLCLIS 634
Cdd:COG1033 547 DYSAARVTVRLKDLDSEEIKALVEEVRAFLAENfPPDGVEVTLT-GSAVLFAAINESVIESQIRSLLLALLLIFLLLLLA 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 635 FRSVKATVAVVLPLYIVSTLAQALMVQLEIGLTVSTLPVIALGVGIGVDYGIYILSSMMGQLKQGVALEVAYRNALAERG 714
Cdd:COG1033 626 FRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTG 705
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 715 SAVLFTGITLAIGVSTWIFSDLKFQVDMGILLTFMFLVNMLGAVLLLPAIGSFLWTDQKK 774
Cdd:COG1033 706 KAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPRIAK 765
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
14-764 |
4.44e-35 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 142.67 E-value: 4.44e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 14 RHRLFAIISFALITCFLLFKATQIQLDASFNKNIPLNHDYMKVYTKHEKQFGGANSILISVCDADgDIFNEEFFTQLKAV 93
Cdd:TIGR00921 2 RFRTAIILVFLALLILSAYGAQHLNVESDTEKQLPKDFESYKWYHVLQREFGTSTKTLLVVIEGD-DVTRKPVLDYMRRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 94 HDQLYFIPGVNrplvnSIFAPSARFVEvvedgfaggpiIPANFTA--DKRGLAVVKENIEKAKvvGRMIASDYSCAMVTA 171
Cdd:TIGR00921 81 EQRLREKPYVT-----NVRSAADIMRQ-----------IPGNFPLpvTMPEVRPLMSEYPRSK--EMFLSKDHTVAIIIV 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 172 QLlETDPQTQEKldtlafaEKLETQVREPLSTDK----VSIHIIGFAKMAGDVAEG-AKGVLLFFAIAIAFTFVMVWLFC 246
Cdd:TIGR00921 143 QL-KSDADYKQV-------VPIYNDVERSLERTNppsgKFLDVTGSPAINYDIEREfGKDMGTTMAISGILVVLVLLLDF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 247 HSLKLTILPIACSIIAVVWQLGLLSSLGFGLDPMSILVPFLVFAIGVSHGVQMIN----DIGKKVSTGSSTRVCCQASFR 322
Cdd:TIGR00921 215 KRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNryeeERDIGRAKGEAIVTAVRRTGR 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 323 ALLIpggiALLSDTIGFLTLLTIDIGIIRELAITASLGVAVIIFTNLILLPVWA-SYMRFEGSVHIQAGTHTDKPNLLDK 401
Cdd:TIGR00921 295 AVLI----ALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLqSIDIGREKVKKEIIAIGGKSSEIEE 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 402 LRELLVKATDRKTAGFIIAFTAVLFAVGYwqadkmrigdlhaGAPSLHQDARYN----------QDTFLISDKYTISSDI 471
Cdd:TIGR00921 371 ELSKVLSITVRHPVPALVAALIITGLGLY-------------GAAGIKPEVNIEkfipqdlpslQARKVIESHMGGSHDF 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 472 LKVIVEAYPAACTEH-DVMERISRFQWQMENVAGVQSAVSLSSVAQSVNAGFNEGNLKWQSLPrntaslvQATSRVETSS 550
Cdd:TIGR00921 438 ATILVKADDVRDPELvRFMDELSRDIKATGVAARVFGAPSIIDLVKEVEGLPAPERSALEPIP-------EDEEGGYISG 510
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 551 GLLDGNCSVMPVIIflnDHKAETIDHVVAKVKEFakaEETDELKFKLASGPVgVMAATNESVSAAQLPMMLYVYGAVILL 630
Cdd:TIGR00921 511 GQIKVAVIQVQLKQ---GEPKVQGRKILRDVQHE---HPPPGVKVGVTGLPV-AFAEMHELVNEGMRRMTIAGAILVLMI 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 631 CLISFRSVKATVAVVLPLYIVSTLAQALMVQLEIGLTVSTLPVIALGVGIGVDYGIYILSSMMGQLKQGVALEvAYRNAL 710
Cdd:TIGR00921 584 LLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGPKE-AITHTM 662
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 1823257784 711 AERGSAVLFTGITLAIGVSTWIFSDLKFQVDMGILLTFMFLVNMLGAVLLLPAI 764
Cdd:TIGR00921 663 ERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPAL 716
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1-380 |
2.56e-28 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 121.51 E-value: 2.56e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 1 MRGFLDILERAVFRHRLFAIISFALITCFLLFKATQIQLDASFNKNIPLNHDYMKVYTKHEKQFGGANSILISV-CDADG 79
Cdd:COG1033 388 LGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVVdTGEPD 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 80 DIFNEEFFTQLKAVHDQLYFIPGVNRplVNSIFAPSARFVEVVEDGFAGGPIIPANftADKRGLAVVKENIEKAKVVGRM 159
Cdd:COG1033 468 GLKDPEVLKEIDRLQDYLESLPEVGK--VLSLADLVKELNQALNEGDPKYYALPES--RELLAQLLLLLSSPPGDDLSRF 543
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 160 IASDYSCAMVTAQLLETDPQTqekldTLAFAEKLETQVREPLSTDKVSIHIIG----FAKMAGDVAEGAKGVLLffaIAI 235
Cdd:COG1033 544 VDEDYSAARVTVRLKDLDSEE-----IKALVEEVRAFLAENFPPDGVEVTLTGsavlFAAINESVIESQIRSLL---LAL 615
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 236 AFTFVMVWLFCHSLKLTILPIACSIIAVVWQLGLLSSLGFGLDPMSILVPFLVFAIGVSHGVQMINDIGKKVSTGSSTRV 315
Cdd:COG1033 616 LLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEE 695
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1823257784 316 CCQASFR----ALLIpGGIALlsdTIGFLTLLTIDIGIIRELAITASLGVAVIIFTNLILLPVWASYMR 380
Cdd:COG1033 696 AIRRALRttgkAILF-TSLTL---AAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLD 760
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
562-764 |
5.38e-17 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 85.59 E-value: 5.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 562 VIIFLNDHKAETIDHVVAKVKEFAKAEETDELKFKLAsGPVGVMAATNESVSAAQLPMMLYVYGAVILLCLISFRSVkat 641
Cdd:COG2409 118 VTVTLDGDAGDEAAEAVDALRDAVAAAPAPGLTVYVT-GPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSL--- 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 642 VAVVLPL------YIVSTLAQALMVQLeIGLTVSTLPVI-ALGVGIGVDYGIYILSSMMGQLKQGVALEVAYRNALAERG 714
Cdd:COG2409 194 VAALLPLltaglaVGVALGLLALLAAF-TDVSSFAPNLLtMLGLGVGIDYALFLVSRYREELRAGEDREEAVARAVATAG 272
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1823257784 715 SAVLFTGITLAIGVSTWIFSDLKFQVDMGILLTFMFLVNMLGAVLLLPAI 764
Cdd:COG2409 273 RAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPAL 322
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
627-764 |
3.19e-10 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 62.31 E-value: 3.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 627 VILLCLISFRSVkatVAVVLPLYIV-----STLAQALMVQLEIGLTVSTLPVI---ALGVGIGVDYGIYILSSMMGQLKQ 698
Cdd:pfam03176 155 IFIILLIVYRSV---VAALLPLLTVglslgAAQGLVAILAHILGIGLSTFALNllvVLLIAVGTDYALFLVSRYREELRA 231
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1823257784 699 GVALEVAYRNALAERGSAVLFTGITLAIGVSTWIFSDLKFQVDMGILLTFMFLVNMLGAVLLLPAI 764
Cdd:pfam03176 232 GEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPAL 297
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
157-764 |
5.29e-10 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 62.86 E-value: 5.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 157 GRMIASDYSCAMVTAQLleTDPQTQEKLDTLafaEKLETQVREpLSTDKVSIHIIGFAKMAGDVAEGAKGVLLFF-AIAI 235
Cdd:COG2409 106 AGLVSEDGKAALVTVTL--DGDAGDEAAEAV---DALRDAVAA-APAPGLTVYVTGPAALAADLNEAFEEDLGRAeLITL 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 236 AFTFVMVWLFCHSLKLTILPIACSIIAVVWQLGLLSSLG--FGLDPMSI-LVPFLVFAIGVSHGVQMIN----DIGKKVS 308
Cdd:COG2409 180 PVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAafTDVSSFAPnLLTMLGLGVGIDYALFLVSryreELRAGED 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 309 TGSSTRVCCQASFRALLIPGGIALlsdtIGFLTLLTIDIGIIRELAITASLGVAVIIFTNLILLP---VWASYMRFEGSV 385
Cdd:COG2409 260 REEAVARAVATAGRAVLFSGLTVA----IALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPallALLGRRVFWPRR 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 386 HIQAGTHTDKPNLLDKLrellVKATDRKTAGFIIAFTAVLFAVGYwqadkmRIGDLHAGAPSLHQ-----DARYNQDtfL 460
Cdd:COG2409 336 PRRRRAAAPESGFWRRL----ARAVVRRPVPVLVAAVAVLLALAL------PALGLRLGLPDADSlpadsPSRQGYD--A 403
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 461 ISDKYTISS-DILKVIVEAypAACTEHDVMERISRFQWQMENVAGVQSAVSlssvaqsvnAGFNEGnlkwqslPRNTASL 539
Cdd:COG2409 404 LAEHFPPGSnGPLTVVVES--DDDLDPADLAALDALAAALAAVPGVASVQP---------PTRPEG-------TDGDAAR 465
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 540 VQATSRVETSSglldgncsvmpviiflndhkAETIDHVvAKVKEFAKAEETDeLKFKLAsGPVGVMAATNESVSAAQLPM 619
Cdd:COG2409 466 LQVVPDGDPDS--------------------PEAIDLV-DRLRDAAAPALEG-AEVLVG-GTTAVNIDISDALADDLPLV 522
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 620 MLYVYGAVILLCLISFRSV----KATVAVVLPL---YIVSTLA---QALMVQLEIGLTVSTLPVIALG--VGIGVDYGIY 687
Cdd:COG2409 523 IPVVLGLIFLLLLLLFRSVvaplKAVLTNLLSLgaaLGVLVLVfqhGWLLLGFTPGPLDSFVPLLLFVilFGLGMDYEVF 602
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 688 ILSSMMGQLKQGVALEVAYRNALAERGSAVLFTGITLAIGVSTWIFSDLKFQVDMGILLTF-----MFLVNMlgavLLLP 762
Cdd:COG2409 603 LVSRIREEYDRGGGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVgvlldAFVVRM----LLVP 678
|
..
gi 1823257784 763 AI 764
Cdd:COG2409 679 AL 680
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
599-764 |
5.81e-10 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 63.07 E-value: 5.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 599 SGPVGVMAATNESVSAAQLPMMLYVYGAVILLCLISFRSVKATVAVVLPLYIVSTLAQALMVQLEI--GLTVSTLPVI-- 674
Cdd:TIGR00833 158 TGPLATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIpgLIGVNAQTTVll 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 675 -ALGVGIGVDYGIYILSSMMGQLKQGVALEVAYRNALAERGSAVLFTGITLAIGVSTWIFSDLKFQVDMGILLTFMFLVN 753
Cdd:TIGR00833 238 tALVIGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVA 317
|
170
....*....|.
gi 1823257784 754 MLGAVLLLPAI 764
Cdd:TIGR00833 318 LLNAVTLTPAL 328
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
598-764 |
1.02e-08 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 58.86 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 598 ASGPVGVMAATNESVSAAQLPMMLYVYGAVILLCLISFRSVKATVAVVLPLYIVSTLAQALMVQLEIGLTVSTLPVIALG 677
Cdd:TIGR03480 696 ATGAPVSILESGDTVVGAFLQAFIYALVAITVLLLLTLRRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLL 775
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 678 VGIGVDYGIYilssMMGQLKQGVALEVAYRNALAErgsAVLFTGITLAIGVSTWIFSDLKFQVDMGILLTFMFLVNMLGA 757
Cdd:TIGR03480 776 LGLGVDFGIY----MVHRWRNGVDSGNLLQSSTAR---AVFFSALTTATAFGSLAVSSHPGTASMGILLSLGLGLTLLCT 848
|
....*..
gi 1823257784 758 VLLLPAI 764
Cdd:TIGR03480 849 LIFLPAL 855
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
157-688 |
3.18e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 50.62 E-value: 3.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 157 GRMIASDYSCAMVTAQLLE--TDPQTQEKLdtLAFAEKLETQVREPLStdKVSIHIIGFAKMAGDVAEGAKG-VLLFFAI 233
Cdd:COG4258 182 GVLVSRDGTWALLLAETRAsgFDTDAQQQL--VAALRAAFAALNAAFP--GAQLLLTGAGLFAVAAAQQIKHdISTIGLI 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 234 AIAFTFVMVWLFCHSLK---LTILPIA----CSIIAVVWQLGLLS--SLGFGldpmSILvpflvfaIGVS--HGVQMIND 302
Cdd:COG4258 258 SLLGILLLLLLVFRSLRpllLGLLPVAvgalAGLAAVSLVFGSVHgiTLGFG----SSL-------IGVAvdYSLHYLTH 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 303 IGkkvSTGSSTRvccQASFRALLIPGGIALLSDTIGFLTLLTIDIGIIRELAITASLGVAVIIFTNLILLPVWASYMRfe 382
Cdd:COG4258 327 RR---AAGEWDP---RAALRRIWPTLLLGLLTTVLGYLALLFSPFPGLRQLGVFAAAGLLAAALTTLLWLPLLLPRAA-- 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 383 gsvhiqAGTHTDKPNLLDKLRELLVKATDRKTAGFIIAFTAVLFAVG--YWQADkmrIGDLHAGAPSL-HQDARYNQDTF 459
Cdd:COG4258 399 ------PRPPAPALALLARLLARWPRRLRWLLALLAVLALASLLGLNrlKWNDD---LRALNPVPAALlAQEARLRALLG 469
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 460 LISDKYTissdilkVIVEAYpaacTEHDVMERISRFQWQMEN------VAGVQS-AVSLSSVAQsvnagfNEGNL-KWQS 531
Cdd:COG4258 470 APDVSQY-------LVVYGP----DAEQALQRNEALLPRLDAlvaqgaIAGYQSlSRLLPSAAT------QQARQaLLPD 532
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 532 LPRNTASLVQAT-------SRVETSSGLLDGNCSVMPVII----------FLNDHKAETIDHVVAKVKEFAKAEETDELK 594
Cdd:COG4258 533 LAALRPRLAEALaglgfrpDAFAPFLADLEAARAAPPLTPedllasplaaALRLLLLGRKDGQWAALVPLRGVDDAAALR 612
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 595 FKLASGPvGV----MAATNESV------SAAQLpmMLYVYGAVILLCLISFRSVKATVAVVLPLYIVSTLAQALMVQLEI 664
Cdd:COG4258 613 AAAAGLP-GVrlvdRKAESSSLfgryrnDALWL--LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGI 689
|
570 580
....*....|....*....|....
gi 1823257784 665 GLTVSTLPVIALGVGIGVDYGIYI 688
Cdd:COG4258 690 PLNLFHLIALLLVLGIGIDYALFF 713
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
14-372 |
3.39e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 50.61 E-value: 3.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 14 RHRLFAIISFALITCFLLFKATQIQLDASFNKNIPLNHDYMKVYTKHEKQFGGAN---SILISVCDA-DGDI--FNEEFF 87
Cdd:TIGR00921 381 RHPVPALVAALIITGLGLYGAAGIKPEVNIEKFIPQDLPSLQARKVIESHMGGSHdfaTILVKADDVrDPELvrFMDELS 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 88 TQLKAvhdqlyfipgvNRPLVNSIFAPS-ARFVEVVEdgfagGPIIPanftaDKRGLAVVKENIEKAKVVGrmiaSDYSC 166
Cdd:TIGR00921 461 RDIKA-----------TGVAARVFGAPSiIDLVKEVE-----GLPAP-----ERSALEPIPEDEEGGYISG----GQIKV 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 167 AMVTAQLLETDPQTQekldtlafAEKLETQVREPLSTDKVSIHIIGFAKMAGDVAEGAKGVLLFFAIAIAFTFVMVWLFC 246
Cdd:TIGR00921 516 AVIQVQLKQGEPKVQ--------GRKILRDVQHEHPPPGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAV 587
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 247 H-SLKLTILPIACSIIAVVWQLGLLSSLGFGLDPMSILVPFLVFAIGVSHGVQMINDIGKKVSTGSSTRVCCQASFRA-- 323
Cdd:TIGR00921 588 FrNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTgp 667
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1823257784 324 LLIPGGialLSDTIGFLTLLTIDIGIIRE------LAITASLGVAVIIFTNLILL 372
Cdd:TIGR00921 668 GILFSG---LTTAGGFLSLLLSHFPIMRNfglvqgIGVLSSLTAALVVFPALLVL 719
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
625-764 |
5.34e-06 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 50.00 E-value: 5.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 625 GAVILLCLISFRSVKATVAVVLPLYI--VSTLAQALMvqleiglTVSTLPVIA-----LGVGIGVDYGIYILSSMMGQLK 697
Cdd:TIGR03480 280 VLVLVLLWLALRSPRLVFAVLVTLIVglILTAAFATL-------AVGHLNLISvafavLFIGLGVDFAIQFSLRYREERF 352
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1823257784 698 QGVALEVAYRNALAERGSAVLFTGITLAIGVSTWIFSDLKFQVDMGILLTFMFLVNMLGAVLLLPAI 764
Cdd:TIGR03480 353 RGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPAL 419
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
163-293 |
7.99e-05 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 46.19 E-value: 7.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 163 DYSCAMVTAQLLETDPQTQEkLDTLAFAEKLETQVREPLSTDKVSIHIIGFAKMAGDVAEGAKGVLLFFAIAIAFTFVMV 242
Cdd:pfam02460 152 SYAKAIVLWYFLKFDEEEVE-EDSKEWEDELSQLLHNKYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFS 230
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1823257784 243 WLFCHSLK------------LTILPIACSIIAVVWQLGLLSSLGFGLDPMSILVPFLVFAIGV 293
Cdd:pfam02460 231 IIVSVTLSsytidwvrskpiLAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGV 293
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
232-374 |
1.52e-04 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 45.42 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 232 AIAIAFTFVMVWLFCHSLkLTILPIACSIIAV-VWQLGLLSSLGFGLDPMSILVpfLVFAIGVSHGVQMINDIGKKVSTG 310
Cdd:pfam02460 646 VITLICMFIVCFLFIPNP-PCVFVITLAIASIdIGVFGFLSLWGVDLDPISMIT--IIMSIGFSVDFSAHIAYHFVRSRG 722
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1823257784 311 SSTRVCCQASFRALLIPGGIALLSDTIGFLTLLTIDIGIIRELAITASLGVAVIIFTNLILLPV 374
Cdd:pfam02460 723 DTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPI 786
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
232-542 |
5.47e-04 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 43.55 E-value: 5.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 232 AIAIAFTFVMVWLFCHSLKLTILP---IACSIIAVvwqLGLLSSLGFGLDPMSILVpfLVFAIG--VSHGVQMINDIGKK 306
Cdd:COG0841 338 LEAILLVVLVVFLFLRSWRATLIPavaIPVSLIGT---FAVMYLLGFSLNILTLFA--LVLAIGivVDDAIVVVENIERH 412
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 307 VSTGSSTRvccQASFR-----------------ALLIPggIALLSDTIGFLtlltidigiIRELAITasLGVAVII--FT 367
Cdd:COG0841 413 MEEGLSPL---EAAIKgarevagaviastltlvAVFLP--LAFMGGITGQL---------FRQFALT--VAIALLIslFV 476
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 368 NLILLPVWASYMRFEGSVHIQAGTHTDKPNLLDKLRE----LLVKATDRKtaGFIIAFTAVLFAVGYWQADKMRIGdlha 443
Cdd:COG0841 477 ALTLTPALCARLLKPHPKGKKGRFFRAFNRGFDRLTRgygrLLRWALRHR--KLTLLVALALLALSVLLFGRLPTE---- 550
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 444 GAPslhqdaryNQDTflisdkytissDILKVIVEAYPAACTE--HDVMERISRFQWQMENVAGVQSAVSLSSVAQSVNAG 521
Cdd:COG0841 551 FFP--------EEDQ-----------GQIIVSVQLPPGTSLErtEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSNSG 611
|
330 340
....*....|....*....|..
gi 1823257784 522 FNEGNLK-WQSLPRNTASLVQA 542
Cdd:COG0841 612 TIFVTLKpWDERDRSADEIIAR 633
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
232-373 |
5.76e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 43.30 E-value: 5.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 232 AIAIAFTFVMVWLFCHSLKLTILPIACSIIAVVWQLGLLSSLGFGLDPMSILVPFLVFAIGVSHGVQMINDIGKKVSTGS 311
Cdd:COG4258 646 LLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFFTEGLLDKGELAR 725
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1823257784 312 strvccqaSFRALLipggIALLSDTIGFLTLLTIDIGIIRELAITASLGVAVIIFTNLILLP 373
Cdd:COG4258 726 --------TLLSIL----LAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLLAPLLAP 775
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
134-373 |
7.56e-04 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 42.28 E-value: 7.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 134 ANFTADKRGLAVVKENIEKAKVVGRMIASDYSCAMVTAQLlETDPQTQEKLDTlafAEKLETQVREPLSTDKVSIHIIGF 213
Cdd:pfam03176 54 DALRADTGHVGSVQDFWGDPDTAALFVSPDGKAAYVVVTL-EGDPGTTEADES---VAAVRDAVEQAPPPEGLKAYLTGP 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 214 AKMAGDVAE-GAKGVLLFFAIAIAFTFVMVWLFCHSLKLTILPIACSIIAVVWQLGLLSSLGFGLD-PMSILVPFLVFAI 291
Cdd:pfam03176 130 AATVADLRDaGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGiGLSTFALNLLVVL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 292 GVSHGVQ----MINDIGKKVSTGSSTRvccQASFRALLIPGGIALLSD---TIGFLTLLTIDIGIIRELAITASLGVAVI 364
Cdd:pfam03176 210 LIAVGTDyalfLVSRYREELRAGEDRE---EAVIRAVRGTGKVVTAAGltvAIAMLALSFARLPVFAQVGPTIAIGVLVD 286
|
....*....
gi 1823257784 365 IFTNLILLP 373
Cdd:pfam03176 287 VLAALTLLP 295
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
113-293 |
1.20e-03 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 42.45 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 113 APSARFVEVVEDGF---AGGPI---IPANFTADKRGLAVVKE---------NIEKAKVVGRMIASDYSCAMVTAQLlETD 177
Cdd:COG2409 395 SPSRQGYDALAEHFppgSNGPLtvvVESDDDLDPADLAALDAlaaalaavpGVASVQPPTRPEGTDGDAARLQVVP-DGD 473
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 178 PQTQEKLDTLafaEKLETQVREPLSTdkVSIHIIGFAKMAGDVAEGAKGVL-LFFAIAIAFTFVMVWLFCHSLKLTILPI 256
Cdd:COG2409 474 PDSPEAIDLV---DRLRDAAAPALEG--AEVLVGGTTAVNIDISDALADDLpLVIPVVLGLIFLLLLLLFRSVVAPLKAV 548
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1823257784 257 ACSIIAV---------VWQLGLLSsLGFGLDPMSILVPFLVFAIGV 293
Cdd:COG2409 549 LTNLLSLgaalgvlvlVFQHGWLL-LGFTPGPLDSFVPLLLFVILF 593
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
626-764 |
2.50e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 41.38 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823257784 626 AVILLCLISFRSVKATVAVVLPLyIVSTLAQALMVQLEIGlTVStlpVIALG-----VGIGVDYGIYILSSMMGQLKQGV 700
Cdd:COG4258 261 GILLLLLLVFRSLRPLLLGLLPV-AVGALAGLAAVSLVFG-SVH---GITLGfgsslIGVAVDYSLHYLTHRRAAGEWDP 335
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1823257784 701 alevayRNALAERGSAVLFTGITLAIGVSTWIFSDLKFQVDMGIL----LTFMFLVnmlgAVLLLPAI 764
Cdd:COG4258 336 ------RAALRRIWPTLLLGLLTTVLGYLALLFSPFPGLRQLGVFaaagLLAAALT----TLLWLPLL 393
|
|
| |
