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Conserved domains on  [gi|1824264890|ref|WP_166642363|]
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sensor histidine kinase [Enterobacter sp. AG326]

Protein Classification

sensor histidine kinase( domain architecture ID 11461754)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0007165|GO:0004673|GO:0000155|GO:0000156
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dpiB super family cl33069
sensor histidine kinase DpiB; Provisional
 2-528 1.05e-143

sensor histidine kinase DpiB; Provisional


The actual alignment was detected with superfamily member PRK15053:

Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 425.02  E-value: 1.05e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890   2 KVSFQIKLFISLVAFFSVLFALLGGYYYADVGKQLYQEMSTRAKIQAEEIALIPTLRNEVEQKNISAIHDFMQKISAHSD 81
Cdd:PRK15053   15 RLAFPLRIFLLILVFSIFVIAALAQYFSASFEDYLTLHVRDMAMNQAKIIASNDSVISAVKTRDYKRLATIANKLQRDTD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890  82 ASFIVIGDNKGQHLFHSVfADRVGTTLVGGDNEAVLQGKSTTTIRKGGLGISLRSKAPIFNAAGQVVGIVSVGYLTSYLD 161
Cdd:PRK15053   95 FDYVVIGDRHSIRLYHPN-PEKIGYPMQFTKPGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSKID 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 162 TITVSKVVNILIAAVLLLIALFIFSWFFTRSIKKQIFSLEPREIGLLVRQQKAMMESIYEGVIAIDDRRRIEVINQAARK 241
Cdd:PRK15053  174 SWRLEFLLPMAGVFVVLLGILMLLSWFFAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRNARK 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 242 LLGLSQPARELRGQLISQVIDPVPFFDTQtmLAKDTHDEICRFNDLTVIASRVHIMLEGSLQGWVITFRDRNEIDSLSAQ 321
Cdd:PRK15053  254 MLGLSSPGRQWLGKPIAEVVRPADFFTEQ--IDEKRQDVVANFNGLSVIANREAIRSGDDLLGAIISFRSKDEISTLNAQ 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 322 LSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGRYEEAIGYIQAQSEHAQELLDFISSRFCSPTLCGLLLGKAARAREKGV 401
Cdd:PRK15053  332 LTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGL 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 402 ELSFDPACRLDRPFQPLGEQELISIIGNLLDNAIEATQRSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFER 481
Cdd:PRK15053  412 KMVIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQ 491

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1824264890 482 GITTKTR--GDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:PRK15053  492 GVSTRADepGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKV 540
 
Name Accession Description Interval E-value
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 2-528 1.05e-143

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 425.02  E-value: 1.05e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890   2 KVSFQIKLFISLVAFFSVLFALLGGYYYADVGKQLYQEMSTRAKIQAEEIALIPTLRNEVEQKNISAIHDFMQKISAHSD 81
Cdd:PRK15053   15 RLAFPLRIFLLILVFSIFVIAALAQYFSASFEDYLTLHVRDMAMNQAKIIASNDSVISAVKTRDYKRLATIANKLQRDTD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890  82 ASFIVIGDNKGQHLFHSVfADRVGTTLVGGDNEAVLQGKSTTTIRKGGLGISLRSKAPIFNAAGQVVGIVSVGYLTSYLD 161
Cdd:PRK15053   95 FDYVVIGDRHSIRLYHPN-PEKIGYPMQFTKPGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSKID 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 162 TITVSKVVNILIAAVLLLIALFIFSWFFTRSIKKQIFSLEPREIGLLVRQQKAMMESIYEGVIAIDDRRRIEVINQAARK 241
Cdd:PRK15053  174 SWRLEFLLPMAGVFVVLLGILMLLSWFFAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRNARK 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 242 LLGLSQPARELRGQLISQVIDPVPFFDTQtmLAKDTHDEICRFNDLTVIASRVHIMLEGSLQGWVITFRDRNEIDSLSAQ 321
Cdd:PRK15053  254 MLGLSSPGRQWLGKPIAEVVRPADFFTEQ--IDEKRQDVVANFNGLSVIANREAIRSGDDLLGAIISFRSKDEISTLNAQ 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 322 LSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGRYEEAIGYIQAQSEHAQELLDFISSRFCSPTLCGLLLGKAARAREKGV 401
Cdd:PRK15053  332 LTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGL 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 402 ELSFDPACRLDRPFQPLGEQELISIIGNLLDNAIEATQRSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFER 481
Cdd:PRK15053  412 KMVIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQ 491

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1824264890 482 GITTKTR--GDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:PRK15053  492 GVSTRADepGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKV 540
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 150-529 8.59e-117

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 350.69  E-value: 8.59e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 150 IVSVGYLTSYLDTITVSKVVNILIAAVLLLIALFIFSWFFTRSIKKQIFSLEpREIGLLVRQQKAMMESIYEGVIAIDDR 229
Cdd:COG3290    25 LLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLL-EEIARLVEEREAVLESIREGVIAVDRD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 230 RRIEVINQAARKLLGLsqparELRGQLISQVIDPVpffdtqtmLAKDTHDEICRFNDLTVIASRVHIMLEGSLQGWVITF 309
Cdd:COG3290   104 GRITLINDAARRLLGL-----DAIGRPIDEVLAEV--------LETGERDEEILLNGRVLVVNRVPIRDDGRVVGAVATF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 310 RDRNEIDSLSAQLSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGRYEEAIGYIQAQSEHAQELLDFISSRFCSPTLCGLL 389
Cdd:COG3290   171 RDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALL 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 390 LGKAARAREKGVELSFDPACRLdrPFQPLGEQELISIIGNLLDNAIEATQRSPLPHAPVEVLIKLSEQELIIEVADQGVG 469
Cdd:COG3290   251 LGKAARARERGIDLTIDIDSDL--PDLPLSDTDLVTILGNLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSGPG 328

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 470 IAPAIRDRIFERGITTKTRGDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPATG 529
Cdd:COG3290   329 IPEELLEKIFERGFSTKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-526 2.48e-38

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 135.88  E-value: 2.48e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 423 LISIIGNLLDNAIEATQRSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTKTRGDHGIGLYLIESYV 502
Cdd:cd16915     1 LITIVGNLIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGERGIGLALVRQSV 80

                          90       100
                  ....*....|....*....|....
gi 1824264890 503 SQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:cd16915    81 ERLGGSITVESEPGGGTTFSIRIP 104
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 423-528 6.37e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 88.09  E-value: 6.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890  423 LISIIGNLLDNAIEATQrsplPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTKTRGD----HGIGLYLI 498
Cdd:smart00387   6 LRQVLSNLLDNAIKYTP----EGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggTGLGLSIV 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 1824264890  499 ESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 420-528 2.26e-17

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 77.79  E-value: 2.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 420 EQELISIIGNLLDNAIEATQRSPlphaPVEVLIKlSEQELIIEVADQGVGIAPAIRDRIFERGITTKTR--GDHGIGLYL 497
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAG----EITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRggGGTGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1824264890 498 IESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
 
Name Accession Description Interval E-value
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 2-528 1.05e-143

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 425.02  E-value: 1.05e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890   2 KVSFQIKLFISLVAFFSVLFALLGGYYYADVGKQLYQEMSTRAKIQAEEIALIPTLRNEVEQKNISAIHDFMQKISAHSD 81
Cdd:PRK15053   15 RLAFPLRIFLLILVFSIFVIAALAQYFSASFEDYLTLHVRDMAMNQAKIIASNDSVISAVKTRDYKRLATIANKLQRDTD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890  82 ASFIVIGDNKGQHLFHSVfADRVGTTLVGGDNEAVLQGKSTTTIRKGGLGISLRSKAPIFNAAGQVVGIVSVGYLTSYLD 161
Cdd:PRK15053   95 FDYVVIGDRHSIRLYHPN-PEKIGYPMQFTKPGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSKID 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 162 TITVSKVVNILIAAVLLLIALFIFSWFFTRSIKKQIFSLEPREIGLLVRQQKAMMESIYEGVIAIDDRRRIEVINQAARK 241
Cdd:PRK15053  174 SWRLEFLLPMAGVFVVLLGILMLLSWFFAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRNARK 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 242 LLGLSQPARELRGQLISQVIDPVPFFDTQtmLAKDTHDEICRFNDLTVIASRVHIMLEGSLQGWVITFRDRNEIDSLSAQ 321
Cdd:PRK15053  254 MLGLSSPGRQWLGKPIAEVVRPADFFTEQ--IDEKRQDVVANFNGLSVIANREAIRSGDDLLGAIISFRSKDEISTLNAQ 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 322 LSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGRYEEAIGYIQAQSEHAQELLDFISSRFCSPTLCGLLLGKAARAREKGV 401
Cdd:PRK15053  332 LTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGL 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 402 ELSFDPACRLDRPFQPLGEQELISIIGNLLDNAIEATQRSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFER 481
Cdd:PRK15053  412 KMVIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQ 491

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1824264890 482 GITTKTR--GDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:PRK15053  492 GVSTRADepGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKV 540
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 150-529 8.59e-117

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 350.69  E-value: 8.59e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 150 IVSVGYLTSYLDTITVSKVVNILIAAVLLLIALFIFSWFFTRSIKKQIFSLEpREIGLLVRQQKAMMESIYEGVIAIDDR 229
Cdd:COG3290    25 LLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLL-EEIARLVEEREAVLESIREGVIAVDRD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 230 RRIEVINQAARKLLGLsqparELRGQLISQVIDPVpffdtqtmLAKDTHDEICRFNDLTVIASRVHIMLEGSLQGWVITF 309
Cdd:COG3290   104 GRITLINDAARRLLGL-----DAIGRPIDEVLAEV--------LETGERDEEILLNGRVLVVNRVPIRDDGRVVGAVATF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 310 RDRNEIDSLSAQLSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGRYEEAIGYIQAQSEHAQELLDFISSRFCSPTLCGLL 389
Cdd:COG3290   171 RDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALL 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 390 LGKAARAREKGVELSFDPACRLdrPFQPLGEQELISIIGNLLDNAIEATQRSPLPHAPVEVLIKLSEQELIIEVADQGVG 469
Cdd:COG3290   251 LGKAARARERGIDLTIDIDSDL--PDLPLSDTDLVTILGNLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSGPG 328

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 470 IAPAIRDRIFERGITTKTRGDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPATG 529
Cdd:COG3290   329 IPEELLEKIFERGFSTKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 1-526 8.00e-99

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 309.54  E-value: 8.00e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890   1 MKVSFQIKLFISLVAFFSVLFALLggYYYADVGKQLYQEMSTRAKIQAEEIALIPTLRNEVEQK-NISAIHDFMQKISAH 79
Cdd:PRK11086   14 MKLSTTVTLMVSAVVFSVLLVVHL--LYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKpDESGIQTYAEAVRKR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890  80 SDASFIVIGDNKGQHLFHSVfADRVGTTLVGGDNEAVLQGKSTTTIRKGGLGISLRSKAPIFNAAGQVVGIVSVGYLTSY 159
Cdd:PRK11086   92 NDLLFIVVTDMQGIRYSHPN-PQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIGVVAVGISLSE 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 160 LDTITVSKVVNILIAAVLLLIALFIFSWFFTRSIKKQIFSLEPREIGLLVRQQKAMMESIYEGVIAIDDRRRIEVINQAA 239
Cdd:PRK11086  171 VTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDRGEVTLINDEA 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 240 RKLLGLSQP-ARELRGQLISQVIdpvPFFDTQTMLAKDT--HDEICRFNDLTVIASRVHIMLEGSLQGWVITFRDRNEID 316
Cdd:PRK11086  251 KRLFNYKKGlEDDPLGTDVESWM---PVSRLKEVLRTGTprRDEEININGRLLLTNTVPVRVNGEIIGAIATFRDKTEVR 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 317 SLSAQLSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGRYEEAIGYIQAQSEHAQELLDFISSRFCSPTLCGLLLGKAARA 396
Cdd:PRK11086  328 QLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLGKISRA 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 397 REKGVELSFDPACRLDRPFQPLGEQELISIIGNLLDNAIEATqrSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRD 476
Cdd:PRK11086  408 RELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAV--GGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEID 485

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 1824264890 477 RIFERGITTKTRGdHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:PRK11086  486 AIFDKGYSTKGSN-RGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-526 2.48e-38

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 135.88  E-value: 2.48e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 423 LISIIGNLLDNAIEATQRSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTKTRGDHGIGLYLIESYV 502
Cdd:cd16915     1 LITIVGNLIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGERGIGLALVRQSV 80

                          90       100
                  ....*....|....*....|....
gi 1824264890 503 SQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:cd16915    81 ERLGGSITVESEPGGGTTFSIRIP 104
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 171-531 3.18e-34

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 133.93  E-value: 3.18e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 171 ILIAAVLLLIALFIFSWF-------------FTRSIKKQIFSLEPR-----EIGLLVR-----------------QQKAM 215
Cdd:COG5000    12 LLIALLLLLLALWLALLLarrltrplrrlaeATRAVAAGDLSVRLPvtgddEIGELARafnrmtdqlkeqreeleERRRY 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 216 MESIYE----GVIAIDDRRRIEVINQAARKLLGLsqPARELRGQLISQVIDPVPFFDTQTMLAKDTHDEICRFNDLTVIA 291
Cdd:COG5000    92 LETILEnlpaGVIVLDADGRITLANPAAERLLGI--PLEELIGKPLEELLPELDLAELLREALERGWQEEIELTRDGRRT 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 292 SRVHIMLEgSLQGWVITFRDRNEIdsLSAQLSQVKRYVdnLRIMRHEQLNRMTTLSGLLHMGRY-------------EEA 358
Cdd:COG5000   170 LLVRASPL-RDDGYVIVFDDITEL--LRAERLAAWGEL--ARRIAHEIKNPLTPIQLSAERLRRkladkleedredlERA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 359 IGYIQAQSEH----AQELLDFisSRFCSPTL--CGL--LLGKAA-----RAREKGVELSFD-----PACRLDRpfqplge 420
Cdd:COG5000   245 LDTIIRQVDRlkriVDEFLDF--ARLPEPQLepVDLneLLREVLalyepALKEKDIRLELDldpdlPEVLADR------- 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 421 QELISIIGNLLDNAIEATQRSPlphaPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTKTRGdHGIGLYLIES 500
Cdd:COG5000   316 DQLEQVLINLLKNAIEAIEEGG----EIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKG-TGLGLAIVKK 390

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1824264890 501 YVSQAGGAIEVADNTPRGAIFSLFIPATGTA 531
Cdd:COG5000   391 IVEEHGGTIELESRPGGGTTFTIRLPLAEEA 421
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
210-528 4.65e-28

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 115.33  E-value: 4.65e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 210 RQQKAMMESIYEGVIAIDDRRRIEVINQAARKLLGLSqpARELRGQLISQVIDPVPFFDTQTMLAKDTHDEICRFN---- 285
Cdd:COG3852     7 ELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLS--AEELLGRPLAELFPEDSPLRELLERALAEGQPVTEREvtlr 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 286 -----DLTVIASRVHIMLEGSLQGWVITFRDRNEIDSLSAQLSQVKRYVDNLRIMR---HEQLNRMTTLSG---LLHM-- 352
Cdd:COG3852    85 rkdgeERPVDVSVSPLRDAEGEGGVLLVLRDITERKRLERELRRAEKLAAVGELAAglaHEIRNPLTGIRGaaqLLERel 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 353 --GRYEEAIGYIQAQSEHAQELLD-FIS-SRFCSP--------TLCGLLLGKAARAREKGVELSFD-----PACRLDRpf 415
Cdd:COG3852   165 pdDELREYTQLIIEEADRLNNLVDrLLSfSRPRPPerepvnlhEVLERVLELLRAEAPKNIRIVRDydpslPEVLGDP-- 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 416 qplgEQeLISIIGNLLDNAIEATQRSPL------PHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTKTRG 489
Cdd:COG3852   243 ----DQ-LIQVLLNLVRNAAEAMPEGGTitirtrVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKG 317

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1824264890 490 dHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:COG3852   318 -TGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLE 355
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
301-528 1.13e-23

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 99.60  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 301 SLQGWVITFRDRNEIDSlsaqlSQVKRYVDNLrimrHEQLNRMTTL-SGLLHMGRYEEAIGYIQAQSEHAQELLDFISSR 379
Cdd:COG2205    33 SILGAAELLLDEEDLSP-----EERRELLEII----RESAERLLRLiEDLLDLSRLESGKLSLELEPVDLAELLEEAVEE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 380 FcsptlcglllgkAARAREKGVELSFDPACrlDRPFQPLGEQELISIIGNLLDNAIEATQrsplPHAPVEVLIKLSEQEL 459
Cdd:COG2205   104 L------------RPLAEEKGIRLELDLPP--ELPLVYADPELLEQVLANLLDNAIKYSP----PGGTITISARREGDGV 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1824264890 460 IIEVADQGVGIAPAIRDRIFE---RGITTKTRGDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:COG2205   166 RISVSDNGPGIPEEELERIFErfyRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
324-528 1.50e-23

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 101.52  E-value: 1.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 324 QVKRYVDNLrimrHEQLNRMTTL-SGLLHMGRYEEAIGYIQAQSEHAQELLDFISSRFcsptlcglllgkAARAREKGVE 402
Cdd:COG0642   142 EQREYLETI----LRSADRLLRLiNDLLDLSRLEAGKLELEPEPVDLAELLEEVVELF------------RPLAEEKGIE 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 403 LSFDPAcrlDRPFQPLGEQELIS-IIGNLLDNAIEATQrsplPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFER 481
Cdd:COG0642   206 LELDLP---DDLPTVRGDPDRLRqVLLNLLSNAIKYTP----EGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEP 278

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1824264890 482 GITTKTRGDH---GIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:COG0642   279 FFRTDPSRRGggtGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 423-528 6.37e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 88.09  E-value: 6.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890  423 LISIIGNLLDNAIEATQrsplPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTKTRGD----HGIGLYLI 498
Cdd:smart00387   6 LRQVLSNLLDNAIKYTP----EGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggTGLGLSIV 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 1824264890  499 ESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 423-525 1.98e-20

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 86.12  E-value: 1.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 423 LISIIGNLLDNAIEATQrsplPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTK---TRGDHGIGLYLIE 499
Cdd:cd00075     1 LEQVLSNLLDNALKYSP----PGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDksrEGGGTGLGLAIVR 76

                          90       100
                  ....*....|....*....|....*.
gi 1824264890 500 SYVSQAGGAIEVADNTPRGAIFSLFI 525
Cdd:cd00075    77 RIVEAHGGRITVESEPGGGTTFTVTL 102
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
301-527 1.18e-18

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 88.07  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 301 SLQGWVITFRDRNEIDSlsaqlSQVKRYvdnLRIMrHEQLNRMTTL-SGLLHMGRYEEAIGYIQAQSEHAQELLDFISSR 379
Cdd:COG5002   182 SIRGYLELLLDGAADDP-----EERREY---LEII-LEEAERLSRLvNDLLDLSRLESGELKLEKEPVDLAELLEEVVEE 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 380 FcsptlcglllgkAARAREKGVELSFDPAcrlDRPFQPLG-EQELISIIGNLLDNAIEATQrsplPHAPVEVLIKLSEQE 458
Cdd:COG5002   253 L------------RPLAEEKGIELELDLP---EDPLLVLGdPDRLEQVLTNLLDNAIKYTP----EGGTITVSLREEDDQ 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1824264890 459 LIIEVADQGVGIAPAIRDRIFER------GITTKTRGdHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPA 527
Cdd:COG5002   314 VRISVRDTGIGIPEEDLPRIFERfyrvdkSRSRETGG-TGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 393-528 2.27e-18

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 86.78  E-value: 2.27e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 393 AARAREKGVELSFD-----PACRLDRpfqplgeQELISIIGNLLDNAIEATQRSPLPHapVEVLIKLSEQELIIEVADQG 467
Cdd:COG4191   229 RPRLKARGIEVELDlppdlPPVLGDP-------GQLEQVLLNLLINAIDAMEEGEGGR--ITISTRREGDYVVISVRDNG 299

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1824264890 468 VGIAPAIRDRIFERGITTKTRGD-HGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:COG4191   300 PGIPPEVLERIFEPFFTTKPVGKgTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 420-528 2.26e-17

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 77.79  E-value: 2.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 420 EQELISIIGNLLDNAIEATQRSPlphaPVEVLIKlSEQELIIEVADQGVGIAPAIRDRIFERGITTKTR--GDHGIGLYL 497
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAG----EITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRggGGTGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1824264890 498 IESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 422-526 2.25e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 72.07  E-value: 2.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 422 ELISIIGNLLDNAIEATQRSPlphapvEVLIK--LSEQELIIEVADQGVGIAPAIRDRIFERGITTKTRGD-HGIGLYLI 498
Cdd:cd16943     3 QLNQVLLNLLVNAAQAMEGRG------RITIRtwAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEgTGLGLSLS 76

                          90       100
                  ....*....|....*....|....*...
gi 1824264890 499 ESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:cd16943    77 YRIIQKHGGTIRVASVPGGGTRFTIILP 104
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 397-525 4.24e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 72.28  E-value: 4.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 397 REKGVELSFDpacrLDRPFQPLGEQE-LISIIGNLLDNAIEatqrspLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIR 475
Cdd:cd16954    15 QRKGVSISLD----ISPELRFPGERNdLMELLGNLLDNACK------WCLEFVEVTARQTDGGLHLIVDDDGPGVPESQR 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1824264890 476 DRIFERGittkTRGD-----HGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFI 525
Cdd:cd16954    85 SKIFQRG----QRLDeqrpgQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
sCache_3_2 pfam17203
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ...
 34-158 6.50e-15

Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 435783 [Multi-domain]  Cd Length: 140  Bit Score: 71.67  E-value: 6.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890  34 KQLYQEMSTRAKIQAEEIALIPTLR-NEVEQKNISAIHDFMQKISAHSDASFIVIGDNKGQHLFHSVfADRVGTTLVG-G 111
Cdd:pfam17203   4 ADLTRQLERRALALARSVAASPVVRvALTDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPD-PERVGRRLSGpA 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1824264890 112 DNEAVLQGKSTTTIRKGGLGISLRSKAPIFNAAGQVVGIVSVGYLTS 158
Cdd:pfam17203  83 TAPALTAGRSYTGTVTGTLGPSLDAKLPIFDADGRVIGIVSVGVKQD 129
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
215-526 7.36e-15

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 77.32  E-value: 7.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 215 MMESIYEGVIAIDDRRRIEVINQAARKLLGLsqPARELRGQLISQVIDP-VPFFDtqtmLAKDTHDEICRFNDLTVIASR 293
Cdd:PRK11360  267 ILESIADGVIAIDRQGKITTMNPAAEVITGL--QRHELVGKPYSELFPPnTPFAS----PLLDTLEHGTEHVDLEISFPG 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 294 VHIMLE------------GSLQGWVITFRDRNEIDSLSAQLSQVKRYVDNLRIMR---HEQLNRMTTLSGLLHMGR---- 354
Cdd:PRK11360  341 RDRTIElsvstsllhnthGEMIGALVIFSDLTERKRLQRRVARQERLAALGELVAgvaHEIRNPLTAIRGYVQIWRqqts 420

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 355 ---YEEAIGYIQAQSEH----AQELLDFI------------------SSRFCSPTlcglllGKAARARekgVELSFD--- 406
Cdd:PRK11360  421 dppSQEYLSVVLREVDRlnkvIDQLLEFSrpresqwqpvslnalveeVLQLFQTA------GVQARVD---FETELDnel 491

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 407 PACRLDRPfqpLGEQELIsiigNLLDNAIEATQRSPLphapVEVLIKL-SEQELIIEVADQGVGIAPAIRDRIFERGITT 485
Cdd:PRK11360  492 PPIWADPE---LLKQVLL----NILINAVQAISARGK----IRIRTWQySDGQVAVSIEDNGCGIDPELLKKIFDPFFTT 560

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1824264890 486 KTRGDhGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:PRK11360  561 KAKGT-GLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
396-532 2.94e-14

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 74.82  E-value: 2.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 396 AREKGVELSFDPACRLdrPFQPLGEQELISIIGNLLDNAIEATQRsplpHAPVEVLIKLSEQELIIEVADQGVGIAPAIR 475
Cdd:PRK10364  324 ANSREIQLRFTANDTL--PEIQADPDRLTQVLLNLYLNAIQAIGQ----HGVISVTASESGAGVKISVTDSGKGIAADQL 397

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1824264890 476 DRIFERGITTKTRGDhGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPATGTAR 532
Cdd:PRK10364  398 EAIFTPYFTTKAEGT-GLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRR 453
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 387-511 5.34e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 66.06  E-value: 5.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 387 GLLLGKAARAREKGVELSfdpaCRLDRPFQ-PLGEQELISIIGNLLDNAIEATQRSPLPHAPVEVLIKLSEQELIIEVAD 465
Cdd:cd16935     4 SLLSEKLELAREKGIEFT----IEIDIPILlPISPLDLCIIFGNLLDNAIEACAKIDKENRFIHLKIRQKKGFLIISIEN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1824264890 466 QGVGIAPairdRIFERGITTKTRGDHGIGLYLIESYVSQAGGAIEV 511
Cdd:cd16935    80 SYEGELK----KKNGLFLSTKKDKNHGIGLKSIREIVKKYNGNLSI 121
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 171-527 5.36e-13

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 71.35  E-value: 5.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 171 ILIAAVLLLIALFIFSWFFTRSIKKQIFSLEPREIGLLVRQQKAMMESIYEGVIAIDDRRRIEVINQAARKLLGLSQPAR 250
Cdd:COG4251   114 LLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLL 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 251 ELRGQLISQVIDPVPFFDTQTMLAKDTHDEICRFNDLTVIASRVHIMLEGSLQGWVITFRDRNEIDSLSAQLSQVKRYVD 330
Cdd:COG4251   194 LLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTA 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 331 NLR-----------IMRH---EQLNRMTTLSGLLHMgRYEEA--------IGYIQAQSEHAQE----LLDFisSRF---- 380
Cdd:COG4251   274 ELErsneeleqfayVASHdlrEPLRKISGFSQLLEE-DYGDKldeegreyLERIRDAAERMQAliddLLAY--SRVgrqe 350

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 381 --CSPTLCGLLLGKA-----ARAREKGVELSFD--PACRLDRpfqplgeQELISIIGNLLDNAIEATQRSPLPHapVEVL 451
Cdd:COG4251   351 leFEPVDLNELLEEVledlePRIEERGAEIEVGplPTVRGDP-------TLLRQVFQNLISNAIKYSRPGEPPR--IEIG 421

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1824264890 452 IKLSEQELIIEVADQGVGIAPAIRDRIFE---RGITTKTRGDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPA 527
Cdd:COG4251   422 AEREGGEWVFSVRDNGIGIDPEYAEKIFEifqRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 203-526 9.82e-13

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 70.39  E-value: 9.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 203 REIGLLVRQQKAMMESIYE----GVIAIDDRRRIEVINQAARKLLGLSQpaRELRGQLISQVIDP-----VPFFDTQTML 273
Cdd:COG5809   130 KRMEEALRESEEKFRLIFNhspdGIIVTDLDGRIIYANPAACKLLGISI--EELIGKSILELIHSddqenVAAFISQLLK 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 274 AKDTHDEICRF-----NDLTVIASRVHIMLEGSLQGWVITFRDRNEidslSAQLSQVKRYVDNLRI-------MRHEQLN 341
Cdd:COG5809   208 DGGIAQGEVRFwtkdgRWRLLEASGAPIKKNGEVDGIVIIFRDITE----RKKLEELLRKSEKLSVvgelaagIAHEIRN 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 342 RMTTLSG---LLHMGRYEEaigyiqaQSEHAQ----EL--LDFISSRFcsptlcgLLLGK-------------------- 392
Cdd:COG5809   284 PLTSLKGfiqLLKDTIDEE-------QKTYLDimlsELdrIESIISEF-------LVLAKpqaikyepkdlntlieevip 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 393 --AARAREKGVELSFDpaCRLDRPfQPLGEQELI-SIIGNLLDNAIEATQRsplphaPVEVLIKLSEQE---LIIEVADQ 466
Cdd:COG5809   350 llQPQALLKNVQIELE--LEDDIP-DILGDENQLkQVFINLLKNAIEAMPE------GGNITIETKAEDddkVVISVTDE 420

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 467 GVGIAPAIRDRIFERGITTKTRGDhGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:COG5809   421 GCGIPEERLKKLGEPFYTTKEKGT-GLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 429-526 2.57e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 63.33  E-value: 2.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 429 NLLDNAIEATQRSPLPhaPVEVLIKLS---EQELIIEVADQGVGIAPAIRDRIFERGITTKTRGDhGIGLYLIESYVSQA 505
Cdd:cd16944    11 NILKNAAEAIEGRPSD--VGEVRIRVEadqDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGT-GLGLAIVKKIMEEH 87

                          90       100
                  ....*....|....*....|.
gi 1824264890 506 GGAIEVADNTPRGAIFSLFIP 526
Cdd:cd16944    88 GGRISLSNREAGGACIRIILP 108
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 203-327 2.92e-12

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 68.64  E-value: 2.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 203 REIGLLVRQQKAMMESIYEGVIAIDDRRRIEVINQAARKLLGLsqPARELRGQLISQVIDPVPFfdTQTMLAKDT-HDEI 281
Cdd:COG3829     4 LELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGL--PREEVIGKNVTELIPNSPL--LEVLKTGKPvTGVI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1824264890 282 CRFND--LTVIASRVHIMLEGSLQGWVITFRDRNEIDSLSAQLSQVKR 327
Cdd:COG3829    80 QKTGGkgKTVIVTAIPIFEDGEVIGAVETFRDITELKRLERKLREEEL 127
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 420-526 5.16e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 62.41  E-value: 5.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 420 EQELIsiigNLLDNAIEATqrSPLPHAPVEVLIKLS---EQELIIEVADQGVGIAPAIRDRIFERGITTKTRGdHGIGLY 496
Cdd:cd16920     2 QQVLI----NLVRNGIEAM--SEGGCERRELTIRTSpadDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEG-LGMGLS 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1824264890 497 LIESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:cd16920    75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-526 1.19e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 61.65  E-value: 1.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 423 LISIIGNLLDNAIEAtqrspLPHAPVEVLIKLSEQE------------LIIEVADQGVGIAPAIRDRIFERGITTKTRGD 490
Cdd:cd16918     1 LIQVFLNLVRNAAQA-----LAGSGGEIILRTRTQRqvtlghprhrlaLRVSVIDNGPGIPPDLQDTIFYPMVSGRENGT 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1824264890 491 hGIGLYLIESYVSQAGGAIEVaDNTPRGAIFSLFIP 526
Cdd:cd16918    76 -GLGLAIAQNIVSQHGGVIEC-DSQPGHTVFSVSLP 109
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 138-527 7.53e-11

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 64.48  E-value: 7.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 138 APIFnAAGQVVGIVSVGYLTSyldtiTVSKVVN------ILIAAVLLLIALFI---FSWFFTRSIkkqifslepreiGLL 208
Cdd:PRK11100  152 APIR-DGGRIIGVLSVGKPNS-----SMAPFIKrserriLWAGALLLGIALLIgagVVWWLNRSI------------RRL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 209 VRqqkammesiYegVIAIDDRRRIEVINQAARKLLGLSQPARELRGQL-----ISQVIdpvpffdtQTMlakdTHdEICr 283
Cdd:PRK11100  214 TR---------Y--ADAVTEGKPVPLPKLGSSELRELAQALESMRVKLegkayVEQYV--------QTL----TH-ELK- 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 284 fNDLTVIasrvhimlegslqgwvitfRDRNEI--DSLSAQlsQVKRYVDNLRimrhEQLNRMTTL-SGLLHMGRYEeaig 360
Cdd:PRK11100  269 -SPLAAI-------------------RGAAELlqEDPPPE--DRARFTGNIL----TQSARLQQLiDRLLELARLE---- 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 361 yiQAQSEHAQELLDFissrfcSPTLCGLLLGKAARAREKGVELSFDPAcrldrPFQPLGEQELIS-IIGNLLDNAIEAtq 439
Cdd:PRK11100  319 --QRQELEVLEPVAL------AALLEELVEAREAQAAAKGITLRLRPD-----DARVLGDPFLLRqALGNLLDNAIDF-- 383

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 440 rSPlPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTKTRGDH----GIGLYLIESYVSQAGGAIEVADNT 515
Cdd:PRK11100  384 -SP-EGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLPRPANGrkstGLGLAFVREVARLHGGEVTLRNRP 461

                         410
                  ....*....|..
gi 1824264890 516 PRGAIFSLFIPA 527
Cdd:PRK11100  462 EGGVLATLTLPR 473
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 426-526 1.52e-10

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 58.27  E-value: 1.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 426 IIGNLLDNAIEATQRSPLPHAPVEvliKLSEQELIIEVADQGVGIAPAIRDRIFER-----GITTKTRGDHGIGLYLIES 500
Cdd:cd16925     8 VVLNLLSNAFKFTPDGGRIRCILE---KFRLNRFLLTVSDSGPGIPPNLREEIFERfrqgdGSSTRAHGGTGLGLSIVKE 84

                          90       100
                  ....*....|....*....|....*.
gi 1824264890 501 YVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:cd16925    85 FVELHGGTVTVSDAPGGGALFQVELP 110
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 426-526 1.41e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 55.58  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 426 IIGNLLDNAIEATQRSplphapvEVLIKLSEQE-------LIIEVADQGVGIAPAIRDRIFER-----GITTKTRGDHGI 493
Cdd:cd16922     4 ILLNLLGNAIKFTEEG-------EVTLRVSLEEeeedgvqLRFSVEDTGIGIPEEQQARLFEPfsqadSSTTRKYGGTGL 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1824264890 494 GLYLIESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:cd16922    77 GLAISKKLVELMGGDISVESEPGQGSTFTFTLP 109
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
399-519 3.03e-09

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 59.26  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 399 KGVELSFDPACRLDrpFqpLGEQ-ELISIIGNLLDNA----IEAtqrsplphapVEVLIKLSEQELIIEVADQGVGIAPA 473
Cdd:PRK10815  358 KGVNITLDISPEIT--F--VGEKnDFMEVMGNVLDNAckycLEF----------VEISARQTDEHLHIVVEDDGPGIPES 423

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1824264890 474 IRDRIFERGITTKT-RGDHGIGLYLIESYVSQAGGAIEVADNTPRGA 519
Cdd:PRK10815  424 KRELIFDRGQRADTlRPGQGLGLSVAREITEQYEGKISAGDSPLGGA 470
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-526 4.66e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 54.21  E-value: 4.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 423 LISIIGNLLDNAIEATQRSplphAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITT----KTRGDHGIGLYLI 498
Cdd:cd16948     6 LSFIIGQIVSNALKYSKQG----GKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGengrNFQESTGMGLYLV 81

                          90       100
                  ....*....|....*....|....*...
gi 1824264890 499 ESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:cd16948    82 KKLCDKLGHKIDVESEVGEGTTFTITFP 109
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
357-526 5.36e-09

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 58.92  E-value: 5.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 357 EAIGYIQAQSEHAQELLDFI-------SSRFCSPTLCGLLLGKAARAR---EKGVELSFDPAcrlDRPFQPLGEQ-ELIS 425
Cdd:PRK13837  487 RYIDEIISAGARARLIIDQIlafgrkgERNTKPFDLSELVTEIAPLLRvslPPGVELDFDQD---QEPAVVEGNPaELQQ 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 426 IIGNLLDNAIEATQrsplphAPVEVLIKLSEQEL-----------------IIEVADQGVGIAPAIRDRIFERGITTKTR 488
Cdd:PRK13837  564 VLMNLCSNAAQAMD------GAGRVDISLSRAKLrapkvlshgvlppgryvLLRVSDTGAGIDEAVLPHIFEPFFTTRAG 637

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1824264890 489 GDhGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:PRK13837  638 GT-GLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 429-527 5.90e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 53.59  E-value: 5.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 429 NLLDNAIEATqrsplpHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFE---RGITTKTR--GDHGIGLYLIESYVS 503
Cdd:cd16939     7 NLLRNALRYA------HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEpfvRLDPSRDRatGGFGLGLAIVHRVAL 80

                          90       100
                  ....*....|....*....|....
gi 1824264890 504 QAGGAIEVADNTPRGAIFSLFIPA 527
Cdd:cd16939    81 WHGGHVECDDSELGGACFRLTWPR 104
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-526 1.20e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 52.71  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 423 LISIIGNLLDNAIEAtqRSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFerGITTKTRGDH-----GIGLYL 497
Cdd:cd16921     1 LGQVLTNLLGNAIKF--RRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVF--GIFQRLHSREeyegtGVGLAI 76

                          90       100
                  ....*....|....*....|....*....
gi 1824264890 498 IESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:cd16921    77 VRKIIERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-523 5.38e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 50.92  E-value: 5.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 423 LISIIGNLLDNAIEATQRSPLPHAPVEVLIKLSEQELIieVADQGVGIAPAIRDRIFERGITTKTRGDhGIGLYLIESY- 501
Cdd:cd16976     1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLV--VRDNGPGIAEEHLSRVFDPFFTTKPVGK-GTGLGLSISYg 77

                          90       100
                  ....*....|....*....|...
gi 1824264890 502 -VSQAGGAIEVADNTPRGAIFSL 523
Cdd:cd16976    78 iVEEHGGRLSVANEEGAGARFTF 100
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-527 7.51e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 50.40  E-value: 7.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 431 LDNAIEATQRSPLPHAPVEVLIKLSEQ--ELIIEVADQGVGIAPAIRDRIFE---RGITTKTR--GDHGIGLYLIESYVS 503
Cdd:cd16949     1 LARALENVLRNALRYSPSKILLDISQDgdQWTITITDDGPGVPEDQLEQIFLpfyRVDSARDResGGTGLGLAIAERAIE 80

                          90       100
                  ....*....|....*....|....
gi 1824264890 504 QAGGAIEVADNTPRGAIFSLFIPA 527
Cdd:cd16949    81 QHGGKIKASNRKPGGLRVRIWLPA 104
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 420-511 9.02e-08

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 50.29  E-value: 9.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 420 EQELISIIGNLLDNAIEATQRSPLPHapvEVLIKLSEQE--LIIEVADqgvgiapAIRDRIFERG--ITTKTRGD-HGIG 494
Cdd:pfam14501   3 DVDLCVIFGNLLDNAIEACSKIDDNR---FIRLKIREKQnfLIIRIEN-------TYEGELKFEGklPSTKTKGDgHGIG 72

                          90
                  ....*....|....*..
gi 1824264890 495 LYLIESYVSQAGGAIEV 511
Cdd:pfam14501  73 LKSIRRIVKKYGGNLST 89
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 459-526 1.32e-07

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 50.07  E-value: 1.32e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1824264890 459 LIIEVADQGVGIAPAIRDRIFERGITTKTRGD-HGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:cd16919    48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKgTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 420-528 3.15e-07

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 52.81  E-value: 3.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 420 EQELISIIGNLLDNAIEAtqrspLPH-APVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTKTRGDhGIGLYLI 498
Cdd:COG5805   393 ENQIKQVFINLIKNAIEA-----MPNgGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGT-GLGLMVS 466

                          90       100       110
                  ....*....|....*....|....*....|
gi 1824264890 499 ESYVSQAGGAIEVADNTPRGAIFSLFIPAT 528
Cdd:COG5805   467 YKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 426-485 7.16e-07

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 49.26  E-value: 7.16e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1824264890 426 IIGNLLDNAIEATQ----RSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITT 485
Cdd:cd16929    47 ILFELLKNAMRATVeshgDDSDDLPPIKVTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYST 110
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 210-263 8.92e-07

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 46.24  E-value: 8.92e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1824264890  210 RQQKAMMESIYEGVIAIDDRRRIEVINQAARKLLGLSQParELRGQLISQVIDP 263
Cdd:smart00091   1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPE--ELIGKSLLELIHP 52
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 426-512 3.83e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 45.52  E-value: 3.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 426 IIGNLLDNAIEATQRSplphapVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFE---RGITTKTRGDHGIGLYLIESYV 502
Cdd:cd16950     4 VLSNLVDNALRYGGGW------VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQpfyRGDNARGTSGTGLGLAIVQRIS 77

                          90
                  ....*....|
gi 1824264890 503 SQAGGAIEVA 512
Cdd:cd16950    78 DAHGGSLTLA 87
PRK13557 PRK13557
histidine kinase; Provisional
 353-529 7.22e-06

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 48.51  E-value: 7.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 353 GRYEEAIGYIQAQSEHA----QELLDF-----ISSRFCSptLCGLLLGK---AARAREKGVELSFDPA-----CRLDrPF 415
Cdd:PRK13557  200 GRMARSVENIRAAAERAatltQQLLAFarkqrLEGRVLN--LNGLVSGMgelAERTLGDAVTIETDLApdlwnCRID-PT 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 416 QplGEQELIsiigNLLDNA-----------IEATQRSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGIT 484
Cdd:PRK13557  277 Q--AEVALL----NVLINArdampeggrvtIRTRNVEIEDEDLAMYHGLPPGRYVSIAVTDTGSGMPPEILARVMDPFFT 350

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1824264890 485 TKTRGD-HGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPATG 529
Cdd:PRK13557  351 TKEEGKgTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASD 396
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 394-526 1.75e-05

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 47.59  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 394 ARAREKGVELSFDPACRLDRPFQplGEQELI-SIIGNLLDNAIEATQRsplphAPVEVLIKLSEQELIIEVADQGVGIAP 472
Cdd:PRK11466  534 GRVKGRPIRLATDIADDLPTALM--GDPRRIrQVITNLLSNALRFTDE-----GSIVLRSRTDGEQWLVEVEDSGCGIDP 606

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1824264890 473 AIRDRIFERGI-TTKTRGDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:PRK11466  607 AKLAEIFQPFVqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
SPOB_a pfam14689
Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B ...
 321-372 1.79e-05

Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerize by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, pfam14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.


Pssm-ID: 434130 [Multi-domain]  Cd Length: 62  Bit Score: 42.62  E-value: 1.79e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1824264890 321 QLSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGRYEEAIGYIQAQSEHAQEL 372
Cdd:pfam14689   5 EINELEELIKALRHQRHDFLNHLQVISGYLQLGRYDRAEEYIKEVVKDLKEE 56
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 427-523 1.87e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 43.60  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 427 IGNLLDNAIEATQrsplPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGIT----TKTRGDHGIGLYLIESYV 502
Cdd:cd16945     9 INNLLDNAIDFSP----EGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprpHSGQKSTGLGLAFVQEVA 84

                          90       100
                  ....*....|....*....|.
gi 1824264890 503 SQAGGAIEVAdNTPRGAIFSL 523
Cdd:cd16945    85 QLHGGRITLR-NRPDGVLAFL 104
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
430-507 1.96e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 44.13  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 430 LLDNAIEATqRSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFErgittkTRGDHGIGLYLIE------SYVS 503
Cdd:COG2172    42 AVTNAVRHA-YGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS------TLAEGGRGLFLIRrlmdevEYES 114


                  ....
gi 1824264890 504 QAGG 507
Cdd:COG2172   115 DPGG 118
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 384-537 2.70e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 46.86  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 384 TLCGLLlgkaarAREKGVELSFDPACRLDRPFQPLGEQeLISIIGNLLDNAIEATQRSplphapvEVLIKLS---EQELI 460
Cdd:PRK11091  367 NLSGLQ------AEQKGLRFDLEPLLPLPHKVITDGTR-LRQILWNLISNAVKFTQQG-------GVTVRVRyeeGDMLT 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 461 IEVADQGVGIAPAIRDRIFERGITTKTRGDH------GIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPATGTARQL 534
Cdd:PRK11091  433 FEVEDSGIGIPEDELDKIFAMYYQVKDSHGGkpatgtGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEEV 512


                  ...
gi 1824264890 535 EDT 537
Cdd:PRK11091  513 EDA 515
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
394-529 4.54e-05

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 45.92  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 394 ARAREKGVELSFD-PACRLDrpfqplGE-QELISIIGNLLDNAIEATqrsPLPHApveVLIKLSEQELIIE--VADQGVG 469
Cdd:PRK09835  351 AWAEERGVELRFVgDPCQVA------GDpLMLRRAISNLLSNALRYT---PAGEA---ITVRCQEVDHQVQlvVENPGTP 418

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1824264890 470 IAPAIRDRIFER----GITTKTRGD-HGIGLYLIESYVSQAGGAIEVADNtPRGAIFSLFIPATG 529
Cdd:PRK09835  419 IAPEHLPRLFDRfyrvDPSRQRKGEgSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVISLPRLE 482
PRK10604 PRK10604
sensor protein RstB; Provisional
 429-526 4.91e-05

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 45.75  E-value: 4.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 429 NLLDNAIE-ATQRsplphapVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFE------RGITTKTrGDHGIGLYLIESY 501
Cdd:PRK10604  326 NLLNNALRyAHSR-------VRVSLLLDGNQACLIVEDDGPGIPPEERERVFEpfvrldPSRDRAT-GGCGLGLAIVHSI 397

                          90       100
                  ....*....|....*....|....*
gi 1824264890 502 VSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:PRK10604  398 ALAMGGSVNCDESELGGARFSFSWP 422
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 213-312 5.16e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 42.79  E-value: 5.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 213 KAMMESIYEGVIAIDDRRRIEVINQAARKLLGLSQParELRGQLISQVI---DPVPFFDTQTMLAKDTHDEIC-----RF 284
Cdd:pfam00989   4 RAILESLPDGIFVVDEDGRILYVNAAAEELLGLSRE--EVIGKSLLDLIpeeDDAEVAELLRQALLQGEESRGfevsfRV 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1824264890 285 NDLTVIASRVHIML----EGSLQGWVITFRDR 312
Cdd:pfam00989  82 PDGRPRHVEVRASPvrdaGGEILGFLGVLRDI 113
PRK15347 PRK15347
two component system sensor kinase;
426-526 6.00e-05

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 45.79  E-value: 6.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 426 IIGNLLDNAIEATqrsplPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTktrGDH----GIGLYLIESY 501
Cdd:PRK15347  517 ILVNLLGNAVKFT-----ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQA---DTHsqgtGLGLTIASSL 588

                          90       100
                  ....*....|....*....|....*
gi 1824264890 502 VSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:PRK15347  589 AKMMGGELTLFSTPGVGSCFSLVLP 613
TyrR COG3283
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ...
 210-261 6.15e-05

Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];


Pssm-ID: 442513 [Multi-domain]  Cd Length: 514  Bit Score: 45.57  E-value: 6.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1824264890 210 RQQKAMMESIYEGVIAIDDRRRIEVINQAARKLLGLSQpaRELRGQLISQVI 261
Cdd:COG3283    80 LELDALLEALPDPVFSIDLKGKIELANPAALSLLGLSE--EELIGQPLSELL 129
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-526 8.50e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 42.17  E-value: 8.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 423 LISIIGNLLDNAIEAtqrSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTKTRGDH-----GIGLYL 497
Cdd:cd16953     1 LGQVLRNLIGNAISF---SPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAfgqhsGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1824264890 498 IESYVSQAGGAIEVADNTP----RGAIFSLFIP 526
Cdd:cd16953    78 SRQIIEAHGGISVAENHNQpgqvIGARFTVQLP 110
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
426-529 1.80e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 44.24  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 426 IIGNLLDNAIEATQRSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFErGITTKTRGdHGIGLY-----LIES 500
Cdd:COG2972   340 ILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLE-ELSSKGEG-RGIGLRnvrerLKLY 417

                          90       100
                  ....*....|....*....|....*....
gi 1824264890 501 YVSQAGgaIEVADNTPRGAIFSLFIPATG 529
Cdd:COG2972   418 YGEEYG--LEIESEPGEGTTVTIRIPLEE 444
PAS_8 pfam13188
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ...
 213-268 1.83e-04

PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463802 [Multi-domain]  Cd Length: 65  Bit Score: 39.84  E-value: 1.83e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1824264890 213 KAMMESIYEGVIAIDDRRRIEVINQAARKLLGlsqpaRELRGQLISQVIDPVPFFD 268
Cdd:pfam13188   4 RALFESSPDGILVLDEGGRIIYVNPAALELLG-----YELLGELLGELLDLLDPLL 54
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 412-523 1.90e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 41.34  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 412 DRPFQPLGEQE-LISIIGNLLDNAIEATQRSPLphapVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGIT-----T 485
Cdd:cd16947     9 DRPIYANANTEaLQRILKNLISNAIKYGSDGKF----LGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTledsrN 84

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1824264890 486 KTRGDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSL 523
Cdd:cd16947    85 SAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTV 122
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 219-263 1.93e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 40.69  E-value: 1.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1824264890 219 IYEGVIAIDDRRRIEVINQAARKLLGLSQParELRGQLISQVIDP 263
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPE--ELIGKSLLDLIHP 43
PRK10337 PRK10337
sensor protein QseC; Provisional
 396-481 2.45e-04

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 43.48  E-value: 2.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 396 AREKGVELSFD-PACRLDRPFQPLgeqeLISI-IGNLLDNAIEATqrsplpHAPVEVLIKLSEQELiiEVADQGVGIAPA 473
Cdd:PRK10337  328 AQQAGIDVRLTlNAHPVIRTGQPL----LLSLlVRNLLDNAIRYS------PQGSVVDVTLNARNF--TVRDNGPGVTPE 395


                  ....*...
gi 1824264890 474 IRDRIFER 481
Cdd:PRK10337  396 ALARIGER 403
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 433-502 3.95e-04

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 39.56  E-value: 3.95e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 433 NAIEATQRSPlPHAPVEVLIKLSEQELIIEVADQGVGIAPaIRDRIFERGITTktrgdHGIGLYLIESYV 502
Cdd:cd16936    11 NAVRHAYRHD-GPGPVRLELDLDPDRLRVEVTDSGPGFDP-LRPADPDAGLRE-----GGRGLALIRALM 73
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 420-519 4.33e-04

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 43.14  E-value: 4.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 420 EQELIsiigNLLDNAIEATqrsplPHAPVEVLIKLSEQELI-IEVADQGVGIApaIRDRIFERGITTKTRGdHGIGLYLI 498
Cdd:COG4192   545 EQVLV----NLLVNALDAV-----ATQPQISVDLLSNAENLrVAISDNGNGWP--LVDKLFTPFTTTKEVG-LGLGLSIC 612

                          90       100
                  ....*....|....*....|.
gi 1824264890 499 ESYVSQAGGAIEVADNTPRGA 519
Cdd:COG4192   613 RSIMQQFGGDLYLASTLERGA 633
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 413-518 4.70e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 40.08  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 413 RPFQPLGEQELIS-IIGNLLDNAIEATqrsplPHAPVeVLIKLSEQEL-IIEVADQGVGIAPAIRDRIFERGITTKTRGD 490
Cdd:cd16940     3 ADIQVQGDALLLFlLLRNLVDNAVRYS-----PQGSR-VEIKLSADDGaVIRVEDNGPGIDEEELEALFERFYRSDGQNY 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 1824264890 491 HGIGLYL--IESYVSQAGGAIEVADNTPRG 518
Cdd:cd16940    77 GGSGLGLsiVKRIVELHGGQIFLGNAQGGG 106
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 420-519 6.43e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 39.37  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 420 EQELISIIGNLLDNAIEATQRSplphAPVEVLIKLSEQELIIEVADQGVGIAPAIRD---RIFERGITTKTRGDH-GIGL 495
Cdd:cd16975     2 TLLLSRALINIISNACQYAPEG----GTVSISIYDEEEYLYFEIWDNGHGFSEQDLKkalELFYRDDTSRRSGGHyGMGL 77

                          90       100
                  ....*....|....*....|....
gi 1824264890 496 YLIESYVSQAGGAIEVADNTPRGA 519
Cdd:cd16975    78 YIAKNLVEKHGGSLIIENSQKGGA 101
PRK10490 PRK10490
sensor protein KdpD; Provisional
 417-526 8.46e-04

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 42.33  E-value: 8.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 417 PLGEQELIsiigNLLDNAIEATQrsplPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERgittKTRGDH----- 491
Cdd:PRK10490  777 PLFERVLI----NLLENAVKYAG----AQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDK----FARGNKesaip 844

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1824264890 492 --GIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:PRK10490  845 gvGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
glnL PRK11073
nitrogen regulation protein NR(II);
215-526 8.72e-04

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 41.61  E-value: 8.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 215 MMESIYEGVIAIDDRRRIEVINQAARKLLglSQPARELRGQLISQVIDpVPFFDTQTMLAKDTHDEICRFNDLT-VIASR 293
Cdd:PRK11073   12 ILNSLINSILLLDDDLAIHYANPAAQQLL--AQSSRKLFGTPLPELLS-YFSLNIELMRESLQAGQGFTDNEVTlVIDGR 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 294 VHIMlegSLQGWVITFR----DRNEIDS---LSAQLSQVKRYV---DNLRIMRHEQLNRMTTLSG---LLHMG----RYE 356
Cdd:PRK11073   89 SHIL---SLTAQRLPEGmillEMAPMDNqrrLSQEQLQHAQQVaarDLVRGLAHEIKNPLGGLRGaaqLLSKAlpdpALT 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 357 EAIGYIQAQSEHAQELLDfissRFCSPTLCGL-----LLGKAARAREKgVELSFDPACRLDRPFQP-----LGEQELI-S 425
Cdd:PRK11073  166 EYTKVIIEQADRLRNLVD----RLLGPQRPGThvtesIHKVAERVVQL-VSLELPDNVRLIRDYDPslpelAHDPDQIeQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 426 IIGNLLDNAIEATQRsplPHAPVEVLIKLSEQELI----------IEVADQGVGIAPAIRDRIFERGITTKtRGDHGIGL 495
Cdd:PRK11073  241 VLLNIVRNALQALGP---EGGTITLRTRTAFQLTLhgeryrlaarIDIEDNGPGIPPHLQDTLFYPMVSGR-EGGTGLGL 316

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1824264890 496 YLIESYVSQAGGAIEVaDNTPRGAIFSLFIP 526
Cdd:PRK11073  317 SIARNLIDQHSGKIEF-TSWPGHTEFSVYLP 346
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 429-526 9.82e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 38.91  E-value: 9.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 429 NLLDNAIeatqRSPLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFE---RGITTKTRGDHGIGLYLIESYVSQA 505
Cdd:cd16923     7 NLLSNAI----KYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFErfyRGDNSRNTEGAGLGLSIAKAIIELH 82

                          90       100
                  ....*....|....*....|.
gi 1824264890 506 GGAIEvADNTPRGAIFSLFIP 526
Cdd:cd16923    83 GGSAS-AEYDDNHDLFKVRLP 102
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 396-526 1.32e-03

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 41.76  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 396 AREKGVELSFDpaCRLDRPFQPLGEQELIS-IIGNLLDNAIEATqrsplPHAPVEVLIKLSEQ-----ELIIEVADQGVG 469
Cdd:PRK11107  383 AHEKGLELTLN--IDPDVPDNVIGDPLRLQqIITNLVGNAIKFT-----ESGNIDILVELRALsntkvQLEVQIRDTGIG 455

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1824264890 470 IAPAIRDRIFE---RGITTKTR--GDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIP 526
Cdd:PRK11107  456 ISERQQSQLFQafrQADASISRrhGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 444-532 1.45e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 41.43  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 444 PHAPVEVLIKLSEQELIIEVADQGVGIAPAIrdrifergittKTRGDHGIGLYLIESYVSQAGGAIEVadNTPRGAIFSL 523
Cdd:COG3920   420 EGGRIRVSWRREDGRLRLTVSDNGVGLPEDV-----------DPPARKGLGLRLIRALVRQLGGTLEL--DRPEGTRVRI 486


                  ....*....
gi 1824264890 524 FIPATGTAR 532
Cdd:COG3920   487 TFPLAELAA 495
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
310-530 1.66e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 40.37  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 310 RDRNEI-----DSLSAQLSQVKRYVDNLRIMRHEQLNRMttlsgllhmgryEEAIGYIQAQSEHAQELLDFISSRFCSPT 384
Cdd:COG4585    52 EERRRIarelhDGVGQSLSAIKLQLEAARRLLDADPEAA------------REELEEIRELAREALAELRRLVRGLRPPA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 385 LCGLLLGKAARA------REKGVELSFDpACRLDRPFQPLGEQELISIIGNLLDNAIEatqrsplpHAP---VEVLIKLS 455
Cdd:COG4585   120 LDDLGLAAALEElaerllRAAGIRVELD-VDGDPDRLPPEVELALYRIVQEALTNALK--------HAGatrVTVTLEVD 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1824264890 456 EQELIIEVADQGVGIAPAirdrifergittkTRGDHGIGLYLIESYVSQAGGAIEVADNTPRGAIFSLFIPATGT 530
Cdd:COG4585   191 DGELTLTVRDDGVGFDPE-------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
433-502 1.83e-03

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 38.42  E-value: 1.83e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 433 NAIEATQRSpLPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFERGITTKtRGDHGIGLYLIESYV 502
Cdd:pfam13581  42 NAVEHAYRE-GPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDLEEPDED-RKEGGRGLALIRGLM 109
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 420-520 2.41e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 37.83  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 420 EQELISIIGNLLDNAIEATQrsplPHAPVEVLIKLSEQELIIEVADQGVGIAPAIRDRIFE---RGITTKTR--GDHGIG 494
Cdd:cd16946     2 RDRLQQLFVNLLENSLRYTD----TGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFErfyRVESSRNRasGGSGLG 77

                          90       100
                  ....*....|....*....|....*.
gi 1824264890 495 LYLIESYVSQAGGAIeVADNTPRGAI 520
Cdd:cd16946    78 LAICHNIALAHGGTI-SAEHSPLGGL 102
PRK11388 PRK11388
DNA-binding transcriptional regulator DhaR; Provisional
 138-261 3.20e-03

DNA-binding transcriptional regulator DhaR; Provisional


Pssm-ID: 183114 [Multi-domain]  Cd Length: 638  Bit Score: 40.43  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824264890 138 APIFNAAGQVVGIVSvgyLTSYLDTITVSKVVniLIAAVLLLIALFIfswfftrsikkQIFSLEpREIGLLVRQQKAMME 217
Cdd:PRK11388  148 TPVFDSKGRLTGTIA---LACPVEQTSAADLP--LTLSIAREVGNLL-----------LTDSLL-AESNRHLNQLNALLE 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1824264890 218 SIYEGVIAIDDRRRIEVINQAARKLLGLSqpARELRGQLISQVI 261
Cdd:PRK11388  211 SMDDGVIAWDEQGNLQFLNAQAARLLRLD--ATASQGRAITELL 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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