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Conserved domains on  [gi|1828802958|ref|WP_167661788|]
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malonyl-ACP O-methyltransferase BioC [Paenalcaligenes hominis]

Protein Classification

malonyl-ACP O-methyltransferase( domain architecture ID 11493568)

malonyl-[acyl-carrier protein] O-methyltransferase BioC is a class I SAM-dependent methyltransferase in the biotin biosynthesis pathway that converts the free carboxyl group of a malonyl-thioester to its methyl ester using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 12-258 4.32e-63

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


:

Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 197.51  E-value: 4.32e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  12 RFSAAASRYDRVAHLQRLVCDTLIETMP--PSLDAQQIMDLGAGTGYASTALQQRFPGSQYWAVDLAEGMLRYMHQHVAA 89
Cdd:TIGR02072   1 SFNKAAKTYDRHAKIQREMAKRLLALLKekGIFIPASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  90 K-AYVCADMECLPFAPNYFDLIISSLAVQWSLNFVQSLEQCYACVRSGGVMQFSTVLEGSLRELKQSWasvddGPHVNRF 168
Cdd:TIGR02072  81 NvQFICGDAEKLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSF-----GQHGLRY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958 169 RTRNDYLSLCHQSqWQIIAVEQRRYCYFYDHVKHLRQELRDLGANHIHGNLQThlgaRRRWQQLIDAYEHYRTSNGLPAT 248
Cdd:TIGR02072 156 LSLDELKALLKNS-FELLTLEEELITLSFDDPLDVLRHLKKTGANGLSSGRTS----RKQLKAFLERYEQEFQPDGLPLT 230

                         250
                  ....*....|
gi 1828802958 249 WDILYITLQK 258
Cdd:TIGR02072 231 YHVVYGIAKK 240
 
Name Accession Description Interval E-value
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 12-258 4.32e-63

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 197.51  E-value: 4.32e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  12 RFSAAASRYDRVAHLQRLVCDTLIETMP--PSLDAQQIMDLGAGTGYASTALQQRFPGSQYWAVDLAEGMLRYMHQHVAA 89
Cdd:TIGR02072   1 SFNKAAKTYDRHAKIQREMAKRLLALLKekGIFIPASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  90 K-AYVCADMECLPFAPNYFDLIISSLAVQWSLNFVQSLEQCYACVRSGGVMQFSTVLEGSLRELKQSWasvddGPHVNRF 168
Cdd:TIGR02072  81 NvQFICGDAEKLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSF-----GQHGLRY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958 169 RTRNDYLSLCHQSqWQIIAVEQRRYCYFYDHVKHLRQELRDLGANHIHGNLQThlgaRRRWQQLIDAYEHYRTSNGLPAT 248
Cdd:TIGR02072 156 LSLDELKALLKNS-FELLTLEEELITLSFDDPLDVLRHLKKTGANGLSSGRTS----RKQLKAFLERYEQEFQPDGLPLT 230

                         250
                  ....*....|
gi 1828802958 249 WDILYITLQK 258
Cdd:TIGR02072 231 YHVVYGIAKK 240
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 1-236 8.05e-43

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 146.06  E-value: 8.05e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958   1 MPNSYKHAVAQRFSAAASRYDRVAHLQRLVCDTLIEtMPPSLDAQQIMDLGAGTGYASTALQQRfpGSQYWAVDLAEGML 80
Cdd:PRK10258    1 MATVNKQAIAAAFGRAAAHYEQHAELQRQSADALLA-MLPQRKFTHVLDAGCGPGWMSRYWRER--GSQVTALDLSPPML 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  81 RYMHQHVAAKAYVCADMECLPFAPNYFDLIISSLAVQWSLNFVQSLEQCYACVRSGGVMQFSTVLEGSLRELKQSWASVD 160
Cdd:PRK10258   78 AQARQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVD 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1828802958 161 DGPHVNRFRTRNDYLSLCHqsQWQIIAVEQRRYCYFYDHVKHLRQeLRDLGANHIHGNLQTHLGARRRWQQLIDAY 236
Cdd:PRK10258  158 ERPHANRFLPPDAIEQALN--GWRYQHHIQPITLWFDDALSAMRS-LKGIGATHLHEGRDPRILTRSQLQRLQLAW 230
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 13-154 1.16e-24

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 95.45  E-value: 1.16e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  13 FSAAASRYDRVAHLqrlvcdtlIETMPPSlDAQQIMDLGAGTGYASTALQQRfpGSQYWAVDLAEGMLRYMHQHVAAKA- 91
Cdd:COG2226     1 FDRVAARYDGREAL--------LAALGLR-PGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGl 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1828802958  92 ---YVCADMECLPFAPNYFDLIISSLAVQWSLNFVQSLEQCYACVRSGGVMQFSTVLEGSLRELKQ 154
Cdd:COG2226    70 nveFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEE 135
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 47-137 9.43e-20

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 81.07  E-value: 9.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  47 IMDLGAGTGYASTALQQRFpGSQYWAVDLAEGMLRYMHQHVAAKA----YVCADMECLPFAPNYFDLIISSLAVQ--WSL 120
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGlnveFVQGDAEDLPFPDGSFDLVVSSGVLHhlPDP 79

                          90
                  ....*....|....*..
gi 1828802958 121 NFVQSLEQCYACVRSGG 137
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 49-139 3.35e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.60  E-value: 3.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  49 DLGAGTGYASTALqQRFPGSQYWAVDLAEGMLRYMHQHVAAK-----AYVCADMECLPF-APNYFDLIISSLAVQWSLNF 122
Cdd:cd02440     4 DLGCGTGALALAL-ASGPGARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPeADESFDVIISDPPLHHLVED 82

                          90
                  ....*....|....*...
gi 1828802958 123 VQS-LEQCYACVRSGGVM 139
Cdd:cd02440    83 LARfLEEARRLLKPGGVL 100
 
Name Accession Description Interval E-value
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 12-258 4.32e-63

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 197.51  E-value: 4.32e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  12 RFSAAASRYDRVAHLQRLVCDTLIETMP--PSLDAQQIMDLGAGTGYASTALQQRFPGSQYWAVDLAEGMLRYMHQHVAA 89
Cdd:TIGR02072   1 SFNKAAKTYDRHAKIQREMAKRLLALLKekGIFIPASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  90 K-AYVCADMECLPFAPNYFDLIISSLAVQWSLNFVQSLEQCYACVRSGGVMQFSTVLEGSLRELKQSWasvddGPHVNRF 168
Cdd:TIGR02072  81 NvQFICGDAEKLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSF-----GQHGLRY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958 169 RTRNDYLSLCHQSqWQIIAVEQRRYCYFYDHVKHLRQELRDLGANHIHGNLQThlgaRRRWQQLIDAYEHYRTSNGLPAT 248
Cdd:TIGR02072 156 LSLDELKALLKNS-FELLTLEEELITLSFDDPLDVLRHLKKTGANGLSSGRTS----RKQLKAFLERYEQEFQPDGLPLT 230

                         250
                  ....*....|
gi 1828802958 249 WDILYITLQK 258
Cdd:TIGR02072 231 YHVVYGIAKK 240
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 1-236 8.05e-43

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 146.06  E-value: 8.05e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958   1 MPNSYKHAVAQRFSAAASRYDRVAHLQRLVCDTLIEtMPPSLDAQQIMDLGAGTGYASTALQQRfpGSQYWAVDLAEGML 80
Cdd:PRK10258    1 MATVNKQAIAAAFGRAAAHYEQHAELQRQSADALLA-MLPQRKFTHVLDAGCGPGWMSRYWRER--GSQVTALDLSPPML 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  81 RYMHQHVAAKAYVCADMECLPFAPNYFDLIISSLAVQWSLNFVQSLEQCYACVRSGGVMQFSTVLEGSLRELKQSWASVD 160
Cdd:PRK10258   78 AQARQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVD 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1828802958 161 DGPHVNRFRTRNDYLSLCHqsQWQIIAVEQRRYCYFYDHVKHLRQeLRDLGANHIHGNLQTHLGARRRWQQLIDAY 236
Cdd:PRK10258  158 ERPHANRFLPPDAIEQALN--GWRYQHHIQPITLWFDDALSAMRS-LKGIGATHLHEGRDPRILTRSQLQRLQLAW 230
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 13-154 1.16e-24

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 95.45  E-value: 1.16e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  13 FSAAASRYDRVAHLqrlvcdtlIETMPPSlDAQQIMDLGAGTGYASTALQQRfpGSQYWAVDLAEGMLRYMHQHVAAKA- 91
Cdd:COG2226     1 FDRVAARYDGREAL--------LAALGLR-PGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGl 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1828802958  92 ---YVCADMECLPFAPNYFDLIISSLAVQWSLNFVQSLEQCYACVRSGGVMQFSTVLEGSLRELKQ 154
Cdd:COG2226    70 nveFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEE 135
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 47-137 9.43e-20

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 81.07  E-value: 9.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  47 IMDLGAGTGYASTALQQRFpGSQYWAVDLAEGMLRYMHQHVAAKA----YVCADMECLPFAPNYFDLIISSLAVQ--WSL 120
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGlnveFVQGDAEDLPFPDGSFDLVVSSGVLHhlPDP 79

                          90
                  ....*....|....*..
gi 1828802958 121 NFVQSLEQCYACVRSGG 137
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 47-143 5.48e-18

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 77.37  E-value: 5.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  47 IMDLGAGTGYASTALQQRfpGSQYWAVDLAEGMLRYMHQHVAAKA--YVCADMECLPFAPNYFDLIISSLAVQWSLNFVQ 124
Cdd:COG2227    28 VLDVGCGTGRLALALARR--GADVTGVDISPEALEIARERAAELNvdFVQGDLEDLPLEDGSFDLVICSEVLEHLPDPAA 105

                          90
                  ....*....|....*....
gi 1828802958 125 SLEQCYACVRSGGVMQFST 143
Cdd:COG2227   106 LLRELARLLKPGGLLLLST 124
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
46-143 6.97e-18

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 76.40  E-value: 6.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  46 QIMDLGAGTGYASTALQQRFPGSQYWAVDLAEGMLRYMHQHVAAKAYVCADMECLPFAPNyFDLIISSLAVQWSLNFVQS 125
Cdd:COG4106     4 RVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVRFVVADLRDLDPPEP-FDLVVSNAALHWLPDHAAL 82

                          90
                  ....*....|....*...
gi 1828802958 126 LEQCYACVRSGGVMQFST 143
Cdd:COG4106    83 LARLAAALAPGGVLAVQV 100
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-139 1.33e-17

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 75.39  E-value: 1.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  49 DLGAGTGYASTALQQRFPgsQYWAVDLAEGMLRY--MHQHVAAKAYVCADMECLPFAPNYFDLIISSLAVQWSLNFVQSL 126
Cdd:pfam08241   2 DVGCGTGLLTELLARLGA--RVTGVDISPEMLELarEKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERAL 79

                          90
                  ....*....|...
gi 1828802958 127 EQCYACVRSGGVM 139
Cdd:pfam08241  80 REIARVLKPGGIL 92
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
4-150 5.01e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 65.40  E-value: 5.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958   4 SYKHAVAQRFSAAASRYDR--VAHLQ----RLVCDTLIETMPPSLDAQqIMDLGAGTGYASTALQQRfpGSQYWAVDLAE 77
Cdd:COG4976     2 ALDAYVEALFDQYADSYDAalVEDLGyeapALLAEELLARLPPGPFGR-VLDLGCGTGLLGEALRPR--GYRLTGVDLSE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1828802958  78 GMLRYMHQHVAAKAYVCADMECLPFAPNYFDLIISSlavqWSLNFVQSLEQCYACV----RSGGVMQFST-VLEGSLR 150
Cdd:COG4976    79 EMLAKAREKGVYDRLLVADLADLAEPDGRFDLIVAA----DVLTYLGDLAAVFAGVaralKPGGLFIFSVeDADGSGR 152
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 49-139 3.35e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.60  E-value: 3.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  49 DLGAGTGYASTALqQRFPGSQYWAVDLAEGMLRYMHQHVAAK-----AYVCADMECLPF-APNYFDLIISSLAVQWSLNF 122
Cdd:cd02440     4 DLGCGTGALALAL-ASGPGARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPeADESFDVIISDPPLHHLVED 82

                          90
                  ....*....|....*...
gi 1828802958 123 VQS-LEQCYACVRSGGVM 139
Cdd:cd02440    83 LARfLEEARRLLKPGGVL 100
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 48-138 1.21e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 54.30  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  48 MDLGAGTGYASTALQQRFPGSQYWAVDLAEGMLRYMHQHVAAKAYVCAD------MECLPFAPNYFDLIISSLAVQWSLN 121
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVrvelfqLDLGELDPGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*..
gi 1828802958 122 FVQSLEQCYACVRSGGV 138
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGV 97
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 1-110 1.49e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 56.70  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958   1 MPNSYK-HAVAQRFSAAASRYDRVAHL-----QRLVCDTLIETMPPSLDaQQIMDLGAGTGYASTALQQR-FPGSQYWAV 73
Cdd:PRK00216    4 VAEEEKqEKVAEMFDSIAPKYDLMNDLlsfglHRVWRRKTIKWLGVRPG-DKVLDLACGTGDLAIALAKAvGKTGEVVGL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1828802958  74 DLAEGML-----RYMHQHVAAKA-YVCADMECLPFAPNYFDLI 110
Cdd:PRK00216   83 DFSEGMLavgreKLRDLGLSGNVeFVQGDAEALPFPDNSFDAV 125
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 24-187 1.91e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 52.43  E-value: 1.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  24 AHLQRLVCDTLIETMPPSLDAQQIMDLGAGTGYASTALQQRfpGSQYWAVDLAegmlRYMHQHVAAKA-YVCADMECLPF 102
Cdd:pfam13489   3 HQRERLLADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQ--GFSVTGVDPS----PIAIERALLNVrFDQFDEQEAAV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958 103 APNYFDLIISSLAVQWSLNFVQSLEQCYACVRSGGVMQFSTVLE--GSLRELKQSWASVDDGPHVNrFRTRNDYLSLCHQ 180
Cdd:pfam13489  77 PAGKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPLAsdEADRLLLEWPYLRPRNGHIS-LFSARSLKRLLEE 155


                  ....*..
gi 1828802958 181 SQWQIIA 187
Cdd:pfam13489 156 AGFEVVS 162
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 33-138 1.72e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 47.22  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  33 TLIETMPPSLdaqQIMDLGAGTGYASTALQQRFpGSQYWAVDLAEGMLRyMHQHVAAKA------YVCADM-ECLPFAPN 105
Cdd:COG0500    19 ALLERLPKGG---RVLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIA-LARARAAKAglgnveFLVADLaELDPLPAE 93

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1828802958 106 YFDLIISSLAVQW--SLNFVQSLEQCYACVRSGGV 138
Cdd:COG0500    94 SFDLVVAFGVLHHlpPEEREALLRELARALKPGGV 128
PRK08317 PRK08317
hypothetical protein; Provisional
 43-137 2.00e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 44.54  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  43 DAQQIMDLGAGTGYASTALQQRF-PGSQYWAVDLAEGMLRYMHQHVAAKA----YVCADMECLPFAPNYFDLIISSLAVQ 117
Cdd:PRK08317   19 PGDRVLDVGCGPGNDARELARRVgPEGRVVGIDRSEAMLALAKERAAGLGpnveFVRGDADGLPFPDGSFDAVRSDRVLQ 98

                          90       100
                  ....*....|....*....|
gi 1828802958 118 WSLNFVQSLEQCYACVRSGG 137
Cdd:PRK08317   99 HLEDPARALAEIARVLRPGG 118
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 43-112 3.20e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 43.98  E-value: 3.20e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1828802958  43 DAQQIMDLGAGTGYASTALQQRFPGSQYWAVDLAEGMLRYMHQHVAAKAY------VCADMECLP--FAPNYFDLIIS 112
Cdd:COG4123    37 KGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLedritvIHGDLKEFAaeLPPGSFDLVVS 114
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 26-111 4.55e-05

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 43.75  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  26 LQRLVCDTLIETMPPslDAQQIMDLGAGTGYASTALQQRFPG---SQYWAVDLAEGMLRYmhqhvAAKAY----VC-ADM 97
Cdd:PRK11088   70 LRDAVANLLAERLDE--KATALLDIGCGEGYYTHALADALPEittMQLFGLDISKVAIKY-----AAKRYpqvtFCvASS 142

                          90
                  ....*....|....
gi 1828802958  98 ECLPFAPNYFDLII 111
Cdd:PRK11088  143 HRLPFADQSLDAII 156
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 34-74 7.64e-05

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 42.48  E-value: 7.64e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1828802958  34 LIETMPPSLDAQqIMDLGAGTGYASTALQQRFPGSQYWAVD 74
Cdd:COG2813    41 LLEHLPEPLGGR-VLDLGCGYGVIGLALAKRNPEARVTLVD 80
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 47-139 1.14e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 41.25  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  47 IMDLGAGTGYASTALQQRF-PGSQYWAVDLAEGMLRYMHQHVAAKAY-----VCADMECLP--FAPNYFDLIISSLAVQW 118
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEELgPNAEVVGIDISEEAIEKARENAQKLGFdnvefEQGDIEELPelLEDDKFDVVISNCVLNH 86

                          90       100
                  ....*....|....*....|.
gi 1828802958 119 SLNFVQSLEQCYACVRSGGVM 139
Cdd:pfam13847  87 IPDPDKVLQEILRVLKPGGRL 107
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 40-139 1.52e-04

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 41.85  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  40 PSLDAQQIMDLGAGTGYASTALQQRFPGSQYWAVDLAEGMLRYMHQHVAAKAYVCADM-ECLPFAPNyfDLIISSLAVQW 118
Cdd:PRK01683   28 PLENPRYVVDLGCGPGNSTELLVERWPAARITGIDSSPAMLAEARSRLPDCQFVEADIaSWQPPQAL--DLIFANASLQW 105

                          90       100
                  ....*....|....*....|.
gi 1828802958 119 SLNFVQSLEQCYACVRSGGVM 139
Cdd:PRK01683  106 LPDHLELFPRLVSLLAPGGVL 126
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 45-139 1.69e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 41.07  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  45 QQIMDLGAGTGYASTALQQRFpGSQYWAVDLAEGMLRYMHQHVAAK------AYVCADMECLPfAPNYFDLIISSLAVQW 118
Cdd:COG2230    53 MRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAgladrvEVRLADYRDLP-ADGQFDAIVSIGMFEH 130

                          90       100
                  ....*....|....*....|...
gi 1828802958 119 --SLNFVQSLEQCYACVRSGGVM 139
Cdd:COG2230   131 vgPENYPAYFAKVARLLKPGGRL 153
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
9-157 3.92e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 40.50  E-value: 3.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958   9 VAQRFSAAASRYDRVAHL-----QRLVCDTLIETMPPsLDAQQIMDLGAGTGYASTALQQRF-PGSQYWAVDLAEGML-- 80
Cdd:pfam01209   4 VGDVFSSVASKYDLMNDVisfgiHRLWKDFTMKCMGV-KRGNKFLDVAGGTGDWTFGLSDSAgSSGKVVGLDINENMLke 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828802958  81 ---RYMHQHVAAKAYVCADMECLPFAPNYFDLIISSLAVQWSLNFVQSLEQCYACVRSGG---VMQFSTVLEGSLRELKQ 154
Cdd:pfam01209  83 gekKAKEEGKYNIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGrvvCLEFSKPENPLLSQAYE 162


                  ...
gi 1828802958 155 SWA 157
Cdd:pfam01209 163 LYF 165
PRK05785 PRK05785
hypothetical protein; Provisional
 47-122 4.90e-03

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 37.36  E-value: 4.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1828802958  47 IMDLGAGTG---YASTALQQRFPgsqyWAVDLAEGMLRymHQHVAAKAYVCAdMECLPFAPNYFDLIISSLAVQWSLNF 122
Cdd:PRK05785   55 VLDVAAGKGelsYHFKKVFKYYV----VALDYAENMLK--MNLVADDKVVGS-FEALPFRDKSFDVVMSSFALHASDNI 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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